Aliases for GUCA1B Gene
External Ids for GUCA1B Gene
Previous GeneCards Identifiers for GUCA1B Gene
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
GeneCards Summary for GUCA1B Gene
GUCA1B (Guanylate Cyclase Activator 1B (Retina)) is a Protein Coding gene. Diseases associated with GUCA1B include guca1b-related retinitis pigmentosa and retinitis pigmentosa 48. Among its related pathways are Signaling by GPCR and Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding and guanylate cyclase regulator activity. An important paralog of this gene is KCNIP3.
UniProtKB/Swiss-Prot for GUCA1B Gene
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure