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Aliases for GTSE1 Gene

Aliases for GTSE1 Gene

  • G2 And S-Phase Expressed 1 2 3 5
  • G-2 And S-Phase Expressed 1 2 3
  • Protein B99 Homolog 3 4
  • GTSE-1 4
  • B99 3

External Ids for GTSE1 Gene

Previous GeneCards Identifiers for GTSE1 Gene

  • GC22P043259
  • GC22P044905
  • GC22P045013
  • GC22P045071
  • GC22P046692
  • GC22P029636

Summaries for GTSE1 Gene

Entrez Gene Summary for GTSE1 Gene

  • The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTSE1 Gene

GTSE1 (G2 And S-Phase Expressed 1) is a Protein Coding gene. Among its related pathways are p53 signaling pathway and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for GTSE1 Gene

  • May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Gene Wiki entry for GTSE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTSE1 Gene

Genomics for GTSE1 Gene

Regulatory Elements for GTSE1 Gene

Enhancers for GTSE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTSE1 on UCSC Golden Path with GeneCards custom track

Promoters for GTSE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTSE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTSE1 Gene

Chromosome:
22
Start:
46,296,014 bp from pter
End:
46,333,699 bp from pter
Size:
37,686 bases
Orientation:
Plus strand

Genomic View for GTSE1 Gene

Genes around GTSE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTSE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTSE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTSE1 Gene

Proteins for GTSE1 Gene

  • Protein details for GTSE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ3-GTSE1_HUMAN
    Recommended name:
    G2 and S phase-expressed protein 1
    Protein Accession:
    Q9NYZ3
    Secondary Accessions:
    • B0QYM3
    • Q20WK2
    • Q53GX5
    • Q5R3I6
    • Q6DHX4
    • Q9BRE0
    • Q9UGZ9
    • Q9Y557

    Protein attributes for GTSE1 Gene

    Size:
    720 amino acids
    Molecular mass:
    76645 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAQ09324.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAQ10552.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GTSE1 Gene

Proteomics data for GTSE1 Gene at MOPED

Post-translational modifications for GTSE1 Gene

Other Protein References for GTSE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GTSE1 Gene

Domains & Families for GTSE1 Gene

Protein Domains for GTSE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTSE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GTSE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GTSE1 Gene

Function for GTSE1 Gene

Molecular function for GTSE1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Gene Ontology (GO) - Molecular Function for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GTSE1: view
genes like me logo Genes that share phenotypes with GTSE1: view

Animal Model Products

miRNA for GTSE1 Gene

miRTarBase miRNAs that target GTSE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTSE1 Gene

Localization for GTSE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTSE1 Gene

Cytoplasm, cytoskeleton. Note=Associated with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTSE1 Gene COMPARTMENTS Subcellular localization image for GTSE1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005881 cytoplasmic microtubule IDA 10974554
genes like me logo Genes that share ontologies with GTSE1: view

Pathways & Interactions for GTSE1 Gene

genes like me logo Genes that share pathways with GTSE1: view

Pathways by source for GTSE1 Gene

1 KEGG pathway for GTSE1 Gene

SIGNOR curated interactions for GTSE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process NAS 10974554
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0046827 positive regulation of protein export from nucleus TAS --
GO:1900182 positive regulation of protein localization to nucleus TAS --
GO:1902749 regulation of cell cycle G2/M phase transition TAS --
genes like me logo Genes that share ontologies with GTSE1: view

Drugs & Compounds for GTSE1 Gene

No Compound Related Data Available

Transcripts for GTSE1 Gene

Unigene Clusters for GTSE1 Gene

G-2 and S-phase expressed 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTSE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for GTSE1 Gene

GeneLoc Exon Structure for
GTSE1
ECgene alternative splicing isoforms for
GTSE1

Expression for GTSE1 Gene

mRNA expression in normal human tissues for GTSE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GTSE1 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for GTSE1 Gene

This gene is overexpressed in Brain (29.9), Liver, secretome (22.0), and Pancreatic juice (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTSE1 Gene



SOURCE GeneReport for Unigene cluster for GTSE1 Gene Hs.386189

genes like me logo Genes that share expression patterns with GTSE1: view

Protein tissue co-expression partners for GTSE1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GTSE1 Gene

Orthologs for GTSE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTSE1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GTSE1 35
  • 72.79 (n)
  • 63.28 (a)
GTSE1 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtse1 35
  • 69.41 (n)
  • 59.72 (a)
Gtse1 16
Gtse1 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTSE1 35
  • 98.96 (n)
  • 97.7 (a)
GTSE1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtse1 35
  • 68.81 (n)
  • 60.06 (a)
cow
(Bos Taurus)
Mammalia GTSE1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTSE1 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTSE1 36
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTSE1 35
  • 49.56 (n)
  • 39.75 (a)
GTSE1 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTSE1 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtse1 35
  • 49.17 (n)
  • 39.64 (a)
Str.2510 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17513 35
zebrafish
(Danio rerio)
Actinopterygii gtse1 36
  • 27 (a)
OneToOne
Species with no ortholog for GTSE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTSE1 Gene

ENSEMBL:
Gene Tree for GTSE1 (if available)
TreeFam:
Gene Tree for GTSE1 (if available)

Paralogs for GTSE1 Gene

No data available for Paralogs for GTSE1 Gene

Variants for GTSE1 Gene

Sequence variations from dbSNP and Humsavar for GTSE1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2281192 - 46,323,223(-) CCCGC(A/G)AAAGC reference, missense
rs140054 - 46,326,503(-) ACGCC(A/G)TGCGC reference, missense
rs6008600 - 46,308,779(+) GCCTC(A/G)CCCGG reference, missense
rs34404175 - 46,308,837(+) CACTG(C/T)TCATG reference, missense
rs35503220 - 46,312,255(+) CGGCC(A/G/T)CCGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GTSE1 Gene

Variant ID Type Subtype PubMed ID
nsv829281 CNV Gain 20364138
dgv5013n71 CNV Loss 21882294
nsv829293 CNV Gain 20364138
nsv915350 CNV Loss 21882294
dgv5014n71 CNV Loss 21882294
dgv1412e1 CNV Complex 17122850
nsv428393 CNV Gain 18775914
nsv471214 CNV Loss 18288195
nsv525512 CNV Loss 19592680
nsv834225 CNV Loss 17160897

Variation tolerance for GTSE1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTSE1 Gene

HapMap Linkage Disequilibrium report
GTSE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTSE1 Gene

Disorders for GTSE1 Gene

Relevant External Links for GTSE1

Genetic Association Database (GAD)
GTSE1
Human Genome Epidemiology (HuGE) Navigator
GTSE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTSE1

No disorders were found for GTSE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTSE1 Gene

Publications for GTSE1 Gene

  1. Cloning, chromosome mapping and functional characterization of a human homologue of murine Gtse-1 (B99) gene. (PMID: 10974554) Monte M. … Schneider C. (Gene 2000) 2 3 4 23 67
  2. The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function. (PMID: 12750368) Monte M. … Schneider C. (J. Biol. Chem. 2003) 2 3
  3. Cell-cycle regulation of the p53-inducible gene B99. (PMID: 10984615) Collavin L. … Schneider C. (FEBS Lett. 2000) 2 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GTSE1 Gene

Sources for GTSE1 Gene

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