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Aliases for GTSE1 Gene

Aliases for GTSE1 Gene

  • G2 And S-Phase Expressed 1 2 3 5
  • G-2 And S-Phase Expressed 1 2 3
  • Protein B99 Homolog 3 4
  • G2 And S Phase-Expressed Protein 1 3
  • GTSE-1 4
  • B99 3

External Ids for GTSE1 Gene

Previous GeneCards Identifiers for GTSE1 Gene

  • GC22P043259
  • GC22P044905
  • GC22P045013
  • GC22P045071
  • GC22P046692
  • GC22P029636

Summaries for GTSE1 Gene

Entrez Gene Summary for GTSE1 Gene

  • The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTSE1 Gene

GTSE1 (G2 And S-Phase Expressed 1) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and CDK-mediated phosphorylation and removal of Cdc6.

Gene Wiki entry for GTSE1 Gene

Additional gene information for GTSE1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTSE1 Gene

Genomics for GTSE1 Gene

Regulatory Elements for GTSE1 Gene

Enhancers for GTSE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H046294 1.1 ENCODE 0.7 +0.4 378 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 TTC38 PKDREJ CDPF1 TRMU GTSE1 GTSE1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTSE1 on UCSC Golden Path with GeneCards custom track

Promoters for GTSE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147363 986 1601 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for GTSE1 Gene

Chromosome:
22
Start:
46,296,014 bp from pter
End:
46,333,699 bp from pter
Size:
37,686 bases
Orientation:
Plus strand

Genomic View for GTSE1 Gene

Genes around GTSE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTSE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTSE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTSE1 Gene

Proteins for GTSE1 Gene

  • Protein details for GTSE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ3-GTSE1_HUMAN
    Recommended name:
    G2 and S phase-expressed protein 1
    Protein Accession:
    Q9NYZ3
    Secondary Accessions:
    • B0QYM3
    • Q20WK2
    • Q53GX5
    • Q5R3I6
    • Q6DHX4
    • Q9BRE0
    • Q9UGZ9
    • Q9Y557

    Protein attributes for GTSE1 Gene

    Size:
    720 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for GTSE1 Gene

Post-translational modifications for GTSE1 Gene

  • Ubiquitination at isoforms=125
  • Modification sites at PhosphoSitePlus

Other Protein References for GTSE1 Gene

No data available for DME Specific Peptides for GTSE1 Gene

Domains & Families for GTSE1 Gene

Gene Families for GTSE1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GTSE1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for GTSE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GTSE1: view

No data available for UniProtKB/Swiss-Prot for GTSE1 Gene

Function for GTSE1 Gene

Gene Ontology (GO) - Molecular Function for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20577264
genes like me logo Genes that share ontologies with GTSE1: view
genes like me logo Genes that share phenotypes with GTSE1: view

Animal Model Products

CRISPR Products

miRNA for GTSE1 Gene

miRTarBase miRNAs that target GTSE1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GTSE1
  • Applied Biological Materials Clones for GTSE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTSE1 Gene

Localization for GTSE1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTSE1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with GTSE1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GTSE1 Gene

Pathways & Interactions for GTSE1 Gene

genes like me logo Genes that share pathways with GTSE1: view

Pathways by source for GTSE1 Gene

1 KEGG pathway for GTSE1 Gene

SIGNOR curated interactions for GTSE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest NAS 10974554
GO:0007017 microtubule-based process NAS 10974554
GO:0030335 positive regulation of cell migration TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0046827 positive regulation of protein export from nucleus TAS --
genes like me logo Genes that share ontologies with GTSE1: view

Drugs & Compounds for GTSE1 Gene

No Compound Related Data Available

Transcripts for GTSE1 Gene

Unigene Clusters for GTSE1 Gene

G-2 and S-phase expressed 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GTSE1
  • Applied Biological Materials Clones for GTSE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GTSE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for GTSE1 Gene

GeneLoc Exon Structure for
GTSE1
ECgene alternative splicing isoforms for
GTSE1

Expression for GTSE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTSE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GTSE1 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for GTSE1 Gene

This gene is overexpressed in Brain (29.9), Liver, secretome (22.0), and Pancreatic juice (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTSE1 Gene



Protein tissue co-expression partners for GTSE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GTSE1 Gene:

GTSE1

SOURCE GeneReport for Unigene cluster for GTSE1 Gene:

Hs.386189

Evidence on tissue expression from TISSUES for GTSE1 Gene

  • Nervous system(4.8)
  • Liver(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with GTSE1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTSE1 Gene

Orthologs for GTSE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTSE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTSE1 33 34
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia GTSE1 33 34
  • 72.79 (n)
mouse
(Mus musculus)
Mammalia Gtse1 33 16 34
  • 69.41 (n)
rat
(Rattus norvegicus)
Mammalia Gtse1 33
  • 68.81 (n)
cow
(Bos Taurus)
Mammalia GTSE1 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTSE1 34
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTSE1 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTSE1 33 34
  • 49.56 (n)
lizard
(Anolis carolinensis)
Reptilia GTSE1 34
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtse1 33
  • 49.17 (n)
Str.2510 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17513 33
zebrafish
(Danio rerio)
Actinopterygii gtse1 34
  • 27 (a)
OneToOne
Species where no ortholog for GTSE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTSE1 Gene

ENSEMBL:
Gene Tree for GTSE1 (if available)
TreeFam:
Gene Tree for GTSE1 (if available)

Paralogs for GTSE1 Gene

No data available for Paralogs for GTSE1 Gene

Variants for GTSE1 Gene

Sequence variations from dbSNP and Humsavar for GTSE1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000139163 -- 46,315,868(+) GCTGC(C/T)TGAGC intron-variant
rs1000143121 -- 46,310,166(+) TCACT(C/T)CTGTG intron-variant
rs1000209156 -- 46,311,470(+) GAAGT(A/G)TACTG intron-variant
rs1000228756 -- 46,324,623(+) TGGCC(A/T)CGCAA intron-variant
rs1000277612 -- 46,294,877(+) TCCTC(C/T)AGGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GTSE1 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
esv2758844 CNV gain+loss 17122850
esv3568458 CNV loss 25503493
esv3568459 CNV loss 25503493
esv3647951 CNV loss 21293372
nsv1066139 CNV gain 25217958
nsv1139073 CNV deletion 24896259
nsv1152661 OTHER inversion 26484159
nsv428393 CNV gain 18775914
nsv471214 CNV loss 18288195
nsv525512 CNV loss 19592680
nsv589136 CNV gain 21841781
nsv829281 CNV gain 20364138
nsv829293 CNV gain 20364138
nsv834225 CNV loss 17160897

Variation tolerance for GTSE1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTSE1 Gene

Human Gene Mutation Database (HGMD)
GTSE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTSE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTSE1 Gene

Disorders for GTSE1 Gene

Relevant External Links for GTSE1

Genetic Association Database (GAD)
GTSE1
Human Genome Epidemiology (HuGE) Navigator
GTSE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTSE1

No disorders were found for GTSE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTSE1 Gene

Publications for GTSE1 Gene

  1. Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene. (PMID: 10974554) Monte M … Schneider C (Gene 2000) 2 3 4 22 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60

Products for GTSE1 Gene

  • Addgene plasmids for GTSE1

Sources for GTSE1 Gene

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