GTPBP6 Gene
protein-coding GIFtS: 46
GCID: GC0XM000161
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GTP binding protein 6 (putative)
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Aliases
for GTPBP6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GTP Binding Protein 6 (Putative)1 2 | | PGPL1 2 3 5 | | FLJ209771 | | Putative GTP-Binding Protein 62 | | Pseudoautosomal GTP-Binding Protein-Like3 |
Export aliases for GTPBP6 gene to outside databasesPrevious GC identifers: GC0YM000160 GC00U931416 |
Summaries
for GTPBP6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GTPBP6:
This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short armsof the X and Y chromosomes. (provided by RefSeq, Nov 2011)
Gene Wiki entry for GTPBP6
|
Genomic Views
for GTPBP6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_000024.9 NC_018934.1 NT_167192.1 NT_167200.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GTPBP6 gene promoter:
CREB HEN1 CRE-BP1 ATF-2 Brachyury
Other transcription factors
Search SABiosciences Chromatin IP Primers for GTPBP6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTPBP6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.33; Yp11.32 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.33 and Yp11.32GTPBP6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM000161: view genomic region
(about GC identifiers)
Start:
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220,013 bp from pter |
End:
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230,886 bp from pter |
Size:
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10,874 bases |
Orientation:
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minus strand |
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Proteins
for GTPBP6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GTPB6_HUMAN, O43824 (See
protein sequence)Recommended Name: Putative GTP-binding protein 6 Size: 516 amino acids; 56883 Da
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Ychromosomes
Sequence caution: Sequence=AAH14636.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAP36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD97132.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA74749.2; Type=Miscellaneousdiscrepancy; Note=Has an upstream in-frame stop codon because of a region of poor sequence quality;
Secondary accessions: Q53F77 Q5HYX8Explore the universe of human proteins at neXtProt for GTPBP6: NX_O43824
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43824
GTPBP6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036359.2
ENSEMBL proteins: ENSP00000383537 ENSP00000316598
Human Recombinant Protein Products for GTPBP6:
GTPBP6 Antibody Products:
Assay Products for GTPBP6: |
Protein
Domains /
Families
for GTPBP6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GTPBP6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43824ProtoNet protein and cluster: O43824 2 Blocks protein families: IPB002917 GTP-binding protein IPB006073 GTP1/OBG GTP-binding protein family signature
UniProtKB/Swiss-Prot: GTPB6_HUMAN, O43824Similarity: Belongs to the HflX GTPase familySimilarity: Contains 1 G (guanine nucleotide-binding) domain |
Function
for GTPBP6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
GTPBP6 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTPBP6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: GTPBP6 (NM_012227) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTPBP6 |
|
Pathways & Interactions
for GTPBP6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GTPBP6
1 Interacting protein for GTPBP6 (O438243) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for GTPBP6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GTPBP6 for compounds About GeneDecksing
 Browse Tocris compounds for GTPBP6
1 HMDB Compound for GTPBP6 About this table
1 Novoseek chemical compound relationship for GTPBP6 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gtp |
56.3 |
4 |
7798313 (1), 8643598 (1), 17347996 (1), 8223626 (1) |
Search CenterWatch for drugs/clinical trials and news about GTPBP6 / GTPB6
|
Transcripts
for GTPBP6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GTPBP6 gene: NM_012227.2 Unigene Cluster for GTPBP6: GTP binding protein 6 (putative) Hs.437145 [show with all ESTs]Unigene Representative Sequence: AK0978723 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485332(uc011mgy.1) ENST00000400701 ENST00000326153(uc004cpe.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTPBP6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTPBP6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GTPBP6 (NM_012227) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GTPBP6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTPBP6 |
Additional cDNA sequence: AK024630.1 AK026462.1 AK074528.1 AK097872.1 AK223412.1 AK296003.1 AK298260.1 BC014636.1 BT007360.1 Y14391.2 17 DOTS entries: DT.447777 DT.95227522 DT.100796372 DT.97845535 DT.121644464 DT.121280244 DT.92435847 DT.100729682 DT.100796374 DT.121280269 DT.75199908 DT.75123910 DT.95092433 DT.121280241 DT.121280260 DT.75196527 DT.95349299 24/137 AceView cDNA sequences (see all 137): AI919168 BM853829 BU527365 CF541422 BM695273 BI438310 BM666442 BM695755 BQ673512 BM665125 BM806770 AA359271 BF348154 AL543887 CA442719 CA426629 BQ918464 BM666133 BI160314 BM984966 BE379119 BF448109 BQ226523 BQ227568
GeneLoc Exon Structure
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Expression
for GTPBP6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GTPBP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGAGGTTC
About this image
See GTPBP6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GTPBP6
SOURCE GeneReport for Unigene cluster: Hs.437145
UniProtKB/Swiss-Prot: GTPB6_HUMAN, O43824Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for GTPBP6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTPBP6
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat GTPBP6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTPBP6 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTPBP6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTPBP6 |
Orthologs
for GTPBP6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GTPBP6 gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for GTPBP6 (if available)
TreeFam Gene Tree for GTPBP6 (if available) |
Paralogs
for GTPBP6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GTPBP6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GTPBP6
1 CNV: 67918
1 Indel: 47787
Locus Specific Mutation Databases (LSDB): GTPBP6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTPBP6 |
|
Disorders
/ Diseases
for GTPBP6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GTPBP6 for disorders About GeneDecksing
OMIM gene information: 300124
OMIM disorders: --
5  diseases for GTPBP6: About MalaCardsklinefelter's syndrome pneumonia tuberculosis malaria
mycobacterium tuberculosis
Export disorders for GTPBP6 gene to outside databases
|
Publications
for GTPBP6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GTPBP6 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with GTPBP6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. (PubMed id 9466997)1, 2, 3 Gianfrancesco F.... Forabosco A. (1998)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
- AGAP1, an endosome-associated, phosphoinositide-dependent ADP- ribosylation factor GTPase-activating protein that affects actin cytoskeleton. (PubMed id 12388557)9 Nie Z.... Randazzo P.A. (2002)
- Study of rab6, a ras-like GTP-binding protein associated with the Golgi complex. (PubMed id 7978884)9 Goud B....Slepnev V. (1994)
- Study of rab6, a ras-like GTP-binding protein associated with the Golgi complex. (PubMed id 8154747)9 Goud B....Mayau V. (1994)
- Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition. (PubMed id 17347996)9 Vawter M.P....DeLisi L.E. (2007)
|
External Searches for GTPBP6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GTPBP6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GTPBP6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GTPBP6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GTPBP6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GTPBP6 gene:
Search GeneIP for patents involving GTPBP6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GTPBP6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | GTPBP6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTPBP6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTPBP6 |
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