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Aliases for GTPBP4 Gene

Aliases for GTPBP4 Gene

  • GTP Binding Protein 4 2 3
  • Chronic Renal Failure Gene Protein 3 4
  • G Protein-Binding Protein CRFG 2 3
  • GTP-Binding Protein NGB 3 4
  • CRFG 3 4
  • NOG1 3 4
  • Nucleolar GTP-Binding Protein 1 3
  • GTP-Binding Protein 2
  • NGB 3

External Ids for GTPBP4 Gene

Previous GeneCards Identifiers for GTPBP4 Gene

  • GC10P001024
  • GC10P000973
  • GC10P001034

Summaries for GTPBP4 Gene

Entrez Gene Summary for GTPBP4 Gene

  • GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTPBP4 Gene

GTPBP4 (GTP Binding Protein 4) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for GTPBP4 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit.

Gene Wiki entry for GTPBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP4 Gene

Genomics for GTPBP4 Gene

Regulatory Elements for GTPBP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GTPBP4 Gene

988,019 bp from pter
1,019,936 bp from pter
31,918 bases
Plus strand

Genomic View for GTPBP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTPBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP4 Gene

Proteins for GTPBP4 Gene

  • Protein details for GTPBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar GTP-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KMC5
    • B4DY13
    • B7Z7A3
    • O95446
    • Q5T3R8
    • Q9NVJ8

    Protein attributes for GTPBP4 Gene

    634 amino acids
    Molecular mass:
    73964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GTPBP4 Gene


neXtProt entry for GTPBP4 Gene

Proteomics data for GTPBP4 Gene at MOPED

Post-translational modifications for GTPBP4 Gene

  • Ubiquitination at Lys25, Lys103, Lys118, Lys145, and Lys181
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GTPBP4 Gene

Domains for GTPBP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
genes like me logo Genes that share domains with GTPBP4: view

No data available for Gene Families for GTPBP4 Gene

Function for GTPBP4 Gene

Molecular function for GTPBP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17210637
GO:0005515 protein binding IPI 17210637
GO:0005525 GTP binding IDA 17210637
GO:0015093 ferrous iron transmembrane transporter activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GTPBP4: view
genes like me logo Genes that share phenotypes with GTPBP4: view

Animal Model Products

miRNA for GTPBP4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTPBP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GTPBP4 Gene

Localization for GTPBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP4 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for GTPBP4 Gene COMPARTMENTS Subcellular localization image for GTPBP4 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GTPBP4: view

Pathways for GTPBP4 Gene

genes like me logo Genes that share pathways with GTPBP4: view

Pathways by source for GTPBP4 Gene

1 KEGG pathway for GTPBP4 Gene

Gene Ontology (GO) - Biological Process for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 17210637
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006184 obsolete GTP catabolic process --
GO:0007264 small GTPase mediated signal transduction --
GO:0008152 metabolic process IDA 17210637
genes like me logo Genes that share ontologies with GTPBP4: view

Drugs for GTPBP4 Gene

(1) HMDB Compounds for GTPBP4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with GTPBP4: view

Transcripts for GTPBP4 Gene

Unigene Clusters for GTPBP4 Gene

GTP binding protein 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTPBP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: - - - -
SP4: -

Relevant External Links for GTPBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTPBP4 Gene

mRNA expression in normal human tissues for GTPBP4 Gene

Protein differential expression in normal tissues for GTPBP4 Gene

This gene is overexpressed in Lung (19.0), Breast (8.9), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTPBP4 Gene

SOURCE GeneReport for Unigene cluster for GTPBP4 Gene Hs.215766

genes like me logo Genes that share expressions with GTPBP4: view

Expression partners for GTPBP4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTPBP4 Gene

Orthologs for GTPBP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTPBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GTPBP4 35
  • 86.01 (n)
  • 93.85 (a)
  • 94 (a)
(Canis familiaris)
Mammalia GTPBP4 35
  • 86.41 (n)
  • 93.85 (a)
  • 94 (a)
(Mus musculus)
Mammalia Gtpbp4 35
  • 88.96 (n)
  • 94.79 (a)
Gtpbp4 16
Gtpbp4 36
  • 95 (a)
(Pan troglodytes)
Mammalia GTPBP4 35
  • 95.92 (n)
  • 95.49 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Gtpbp4 35
  • 88.17 (n)
  • 94.95 (a)
(Monodelphis domestica)
Mammalia GTPBP4 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
-- 36
  • 87 (a)
(Gallus gallus)
Aves GTPBP4 35
  • 78.55 (n)
  • 86.53 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia GTPBP4 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp4 35
  • 74.3 (n)
  • 83.1 (a)
Str.2929 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24805 35
(Danio rerio)
Actinopterygii gtpbp4 35
  • 72.05 (n)
  • 82.88 (a)
wufi28d07 35
gtpbp4 36
  • 83 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007050 35
  • 58.93 (n)
  • 60.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8801 35
  • 58.76 (n)
  • 60.92 (a)
CG8801 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea T07A9.9 35
  • 58.4 (n)
  • 58.29 (a)
T07A9.9 36
  • 52 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR194W 35
  • 54.31 (n)
  • 48.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24135g 35
  • 53.61 (n)
  • 47.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOG1 35
  • 52.52 (n)
  • 47.38 (a)
NOG1 36
  • 46 (a)
NOG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10300 35
  • 56.52 (n)
  • 54.5 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5831 35
(Hordeum vulgare)
Liliopsida Hv.4238 35
(Oryza sativa)
Liliopsida Os.14676 35
Os07g0110200 35
  • 52.35 (n)
  • 45.25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05289 35
  • 52.71 (n)
  • 52.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nog1 35
  • 54.85 (n)
  • 54.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3484 36
  • 63 (a)
Species with no ortholog for GTPBP4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP4 Gene

Gene Tree for GTPBP4 (if available)
Gene Tree for GTPBP4 (if available)

Paralogs for GTPBP4 Gene

No data available for Paralogs for GTPBP4 Gene

Variants for GTPBP4 Gene

Sequence variations from dbSNP and Humsavar for GTPBP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs14585 -- 1,017,534(-) GAAAA(A/T)AAGGT utr-variant-3-prime
rs1250883 -- 988,276(-) GGGCC(C/T)CAGGA upstream-variant-2KB
rs1250884 -- 988,118(-) GGAGG(A/G)TCCGG upstream-variant-2KB
rs1250889 -- 996,522(-) AGCCA(C/G)CTTAG intron-variant
rs1250891 -- 994,219(-) AGGTA(C/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP4 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
esv2551854 CNV Insertion 19546169
esv2729239 CNV Deletion 23290073
esv2729251 CNV Deletion 23290073
esv2729262 CNV Deletion 23290073
esv24871 CNV Gain 19812545
esv1067888 CNV Deletion 17803354
esv2729273 CNV Deletion 23290073
esv2729284 CNV Deletion 23290073
esv2729295 CNV Deletion 23290073
esv2729306 CNV Deletion 23290073
esv1468754 CNV Insertion 17803354
dgv589n71 CNV Loss 21882294
dgv86e201 CNV Deletion 23290073
esv1989555 CNV Deletion 18987734
esv2729328 CNV Deletion 23290073
esv2729339 CNV Deletion 23290073

Relevant External Links for GTPBP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP4 Gene

Disorders for GTPBP4 Gene

Relevant External Links for GTPBP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for GTPBP4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GTPBP4 Gene

Publications for GTPBP4 Gene

  1. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. (PMID: 11316846) Laping N.J. … Zhu Y. (J. Am. Soc. Nephrol. 2001) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for GTPBP4 Gene

Sources for GTPBP4 Gene

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