Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GTPBP4 Gene

protein-coding   GIFtS: 60
GCID: GC10P001034

GTP Binding Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
GTP Binding Protein 41 2     GTP-Binding Protein NGB2 3
G Protein-Binding Protein CRFG1 2      GTP-Binding Protein1
Chronic Renal Failure Gene Protein2 3     NGB2
CRFG2 3     Nucleolar GTP-Binding Protein 12
NOG12 3     

External Ids:    HGNC: 215351   Entrez Gene: 235602   Ensembl: ENSG000001079377   UniProtKB: Q9BZE43   

Export aliases for GTPBP4 gene to outside databases

Previous GC identifers: GC10P001024 GC10P000988 GC10P000973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GTPBP4 Gene:
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when
GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a
signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor,
the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing
them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own
bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse
away from the receptor and deliver its message for a prolonged period to its downstream target. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GTPBP4 Gene:
GTPBP4 (GTP binding protein 4) is a protein-coding gene. Diseases associated with GTPBP4 include neurofibromatosis, and malignant mesothelioma. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4
Function: Involved in the biogenesis of the 60S ribosomal subunit (By similarity)

Gene Wiki entry for GTPBP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTPBP4 gene promoter:
         STAT1   STAT1beta   Ik-3   STAT1alpha   GATA-1   CREB   IRF-2   POU2F1   POU2F1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTPBP4 promoter sequence
   Search Chromatin IP Primers for GTPBP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTPBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14   Ensembl cytogenetic band:  10p15.3   HGNC cytogenetic band: 10p15-p14

GTPBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTPBP4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P001034:  view genomic region     (about GC identifiers)

Start:
1,034,338 bp from pter      End:
1,065,876 bp from pter
Size:
31,539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4 (See protein sequence)
Recommended Name: Nucleolar GTP-binding protein 1  
Size: 634 amino acids; 73964 Da
Secondary accessions: B3KMC5 O95446 Q5T3R8 Q9NVJ8

Explore the universe of human proteins at neXtProt for GTPBP4: NX_Q9BZE4

Explore proteomics data for GTPBP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys103, Lys118, Lys145, Lys181
  • Modification sites at PhosphoSitePlus

  • See GTPBP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036473.2  
    ENSEMBL proteins: 
     ENSP00000354040   ENSP00000353168   ENSP00000445473   ENSP00000444277  

    GTPBP4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GTPBP4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GTPBP4
    GenScript Custom Purified and Recombinant Proteins Services for GTPBP4
    Novus Biologicals GTPBP4 Protein
    Novus Biologicals GTPBP4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GTPBP4

    GTPBP4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GTPBP4
    OriGene Custom Antibody Services for GTPBP4
    Novus Biologicals GTPBP4 Antibodies
    Abcam antibodies for GTPBP4
    Cloud-Clone Corp. Antibodies for GTPBP4
    ThermoFisher Antibodies for GTPBP4
    LSBio Antibodies in human, mouse, rat for GTPBP4

    GTPBP4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GTPBP4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTPBP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GTPBP4
    Cloud-Clone Corp. CLIAs for GTPBP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR024926 NOG1
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR010674 NOG1_Rossman_fold_dom
     IPR006073 GTP_binding_domain

    Graphical View of Domain Structure for InterPro Entry Q9BZE4

    ProtoNet protein and cluster: Q9BZE4

    3 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature
    IPB010674 Nucleolar GTP-binding 1


    UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4
    Similarity: Belongs to the GTP1/OBG family. NOG subfamily


    GTPBP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOG1_HUMAN, Q9BZE4
    Function: Involved in the biogenesis of the 60S ribosomal subunit (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA17210637
    GO:0005515protein binding IPI17210637
    GO:0005525GTP binding IDA17210637
    GO:0015093ferrous iron transmembrane transporter activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    GTPBP4 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for GTPBP4:
     Decreased TP53 protein express  Decreased Wnt reporter activit  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTPBP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTPBP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GTPBP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GTPBP4

    miRNA
    Products:
        
    miRTarBase miRNAs that target GTPBP4:
    hsa-mir-92a-1-5p (MIRT038918), hsa-mir-375 (MIRT019721), hsa-mir-16-5p (MIRT051261), hsa-mir-26b-5p (MIRT028964)

    Block miRNA regulation of human, mouse, rat GTPBP4 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GTPBP4:
    hsa-miR-1261 hsa-miR-330-3p hsa-miR-32* hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidGTPBP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GTPBP4
    Predesigned siRNA for gene silencing in human, mouse, rat GTPBP4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GTPBP4

    Clone
    Products:
         
    OriGene clones in human, mouse for GTPBP4 (see all 7)
    OriGene ORF clones in mouse, rat for GTPBP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GTPBP4 (NM_012341)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTPBP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTPBP4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GTPBP4
    Browse ESI BIO Cell Lines and PureStem Progenitors for GTPBP4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTPBP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NOG1_HUMAN, Q9BZE4: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    GTPBP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GTPBP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for GTPBP4):
        Ribosome biogenesis in eukaryotes


    GTPBP4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTPBP4
    Interactions:

        GeneGlobe Interaction Network for GTPBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTPBP4 (Q9BZE41, 2, 3 ENSP000003540404) via UniProtKB, MINT, STRING, and/or I2D (see all 913)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA17210637
    GO:0006184GTP catabolic process IDA17210637
    GO:0007264small GTPase mediated signal transduction ----
    GO:0008156negative regulation of DNA replication IMP17210637
    GO:0008285negative regulation of cell proliferation IMP17210637

    GTPBP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTPBP4 (NOG1)

    1 HMDB Compound for GTPBP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GTPBP4 gene: 
    NM_012341.2  

    Unigene Cluster for GTPBP4:

    GTP binding protein 4
    Hs.215766  [show with all ESTs]
    Unigene Representative Sequence: AK126769
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360803(uc001ift.3 uc010qad.2) ENST00000491635(uc010qac.1)
    ENST00000360059 ENST00000491261 ENST00000483839 ENST00000545048(uc010qae.2)
    ENST00000538293
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GTPBP4 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GTPBP4:
    hsa-miR-1261 hsa-miR-330-3p hsa-miR-32* hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidGTPBP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GTPBP4
    Predesigned siRNA for gene silencing in human, mouse, rat GTPBP4
    Clone
    Products:
         
    OriGene clones in human, mouse for GTPBP4 (see all 7)
    OriGene ORF clones in mouse, rat for GTPBP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GTPBP4 (NM_012341)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTPBP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTPBP4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GTPBP4
    OriGene qSTAR qPCR primer pairs in human, mouse for GTPBP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTPBP4
      QuantiTect SYBR Green Assays in human, mouse, rat GTPBP4
      QuantiFast Probe-based Assays in human, mouse, rat GTPBP4

    Additional mRNA sequence: 

    AF120334.1 AF325353.1 AK001548.1 AK001552.1 AK097093.1 AK126769.1 AK222861.1 AK295231.1 
    AK301721.1 AK302219.1 BC008683.1 BC021243.2 BC033784.1 BC038975.2 

    10 DOTS entries:

    DT.446676  DT.100793039  DT.121275758  DT.95272319  DT.121275655  DT.100702798  DT.121275763  DT.448603 
    DT.121275725  DT.75197811 

    Selected AceView cDNA sequences (see all 306):

    CB110624 BI756794 CB129706 BU633657 BU186693 T51024 BC021243 BM746603 
    BM973142 BM853219 BG251553 AI923217 BU158701 CB140332 AI762903 AW576508 
    BM452527 BM932275 CB137547 AW274978 BG026401 AA598422 BU943722 AW007809 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                       -                                         -                 -           -                                 
    SP2:              -           -                                                     -                 -                                             
    SP3:                                                                                                                                                
    SP4:              -                                                                                                                                 
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for GTPBP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GTPBP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGGAGC
    GTPBP4 Expression
    About this image

    GTPBP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTPBP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.215766
        Custom PCR Arrays for GTPBP4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GTPBP4
    OriGene qSTAR qPCR primer pairs in human, mouse for GTPBP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTPBP4
    QuantiTect SYBR Green Assays in human, mouse, rat GTPBP4
    QuantiFast Probe-based Assays in human, mouse, rat GTPBP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTPBP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GTPBP4 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtpbp41 , 5 GTP binding protein 41, 5 88.96(n)1
    94.79(a)1
      13 (3.64 cM)5
    692371  NM_027000.41  NP_081276.21 
     89724645 
    chicken
    (Gallus gallus)
    Aves GTPBP41 GTP binding protein 4 78.55(n)
    86.53(a)
      420458  NM_001006354.1  NP_001006354.1 
    lizard
    (Anolis carolinensis)
    Reptilia GTPBP46
    GTP binding protein 4
    85(a)
    1 ↔ 1
    6(8095733-8110818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.248052 Xenopus laevis transcribed sequence with strong similarity more 79.21(n)    CD324961.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi28d072 wufi28d07 75.23(n)   334050  BC045447.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88011 CG8801 58.76(n)
    60.92(a)
      35963  NM_136640.4  NP_610484.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T07A9.91 T07A9.9 58.4(n)
    58.29(a)
      176863  NM_171242.3  NP_741288.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOG1(YPL093W)4
    NOG11
    Putative GTPase that associates with free 60S ribosomal more4
    NOG11
    52.52(n)1
    47.38(a)1
      16(370978-372921)4
    8560121, 4  NP_015232.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G103001 AT1G10300 56.52(n)
    54.5(a)
      837569  NM_100904.1  NP_172501.1 
    rice
    (Oryza sativa)
    Liliopsida Os.146762 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.36(n)    NM_186171.1 


    ENSEMBL Gene Tree for GTPBP4 (if available)
    TreeFam Gene Tree for GTPBP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GTPBP4 (see all 861)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127778011,2
    C,F,H--967268(+) TTGAGT/AGAGTG 1 -- int17Minor allele frequency- A:0.06NS EA NA 522
    rs2017354661,2
    C--967310(+) AAATG-/CATTAG 1 -- int10--------
    rs1820381411,2
    --967599(+) TGAACC/TGAGAT 1 -- int10--------
    rs1468689141,2
    --967605(+) GAGATC/TGCGCC 1 -- int10--------
    rs1155491251,2
    F--967823(+) TTGGTC/TCCCCT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1866349191,2
    --967824(+) TGGTCC/GCCCTT 1 -- int10--------
    rs1901175591,2
    --967827(+) TCCCCC/TTTCAG 1 -- int10--------
    rs1172856531,2
    C,F--967847(+) ACGGCA/TTTAGG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1824945041,2
    --967863(+) AAGAAC/TGTAGA 1 -- int10--------
    rs70815161,2
    C,F,A--968010(+) AGACTG/CTTGTG 1 -- int18Minor allele frequency- C:0.25NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for GTPBP4 (1034338 - 1065876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GTPBP4 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1989555CNV Deletion18987734
    esv2729295CNV Deletion23290073
    esv1067888CNV Deletion17803354
    esv2660097CNV Deletion23128226
    esv2729339CNV Deletion23290073
    dgv86e201CNV Deletion23290073
    esv2729306CNV Deletion23290073
    esv2729273CNV Deletion23290073
    esv2729239CNV Deletion23290073
    esv2729328CNV Deletion23290073

    Human Gene Mutation Database (HGMD): GTPBP4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTPBP4
    DNA2.0 Custom Variant and Variant Library Synthesis for GTPBP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    6 diseases for GTPBP4:    
    About MalaCards
    neurofibromatosis    malignant mesothelioma    alzheimer's disease    hiv-1
    breast cancer    malaria


    GTPBP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GTPBP4
    Human Genome Epidemiology (HuGE) Navigator: GTPBP4 (1 document)

    Export disorders for GTPBP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GTPBP4 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with GTPBP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. (PubMed id 11316846)1, 2, 3 Laping N.J.... Zhu Y. (J. Am. Soc. Nephrol. 2001)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23560 HGNC: 21535 AceView: GTPBP4 Ensembl:ENSG00000107937 euGenes: HUgn23560
    ECgene: GTPBP4 Kegg: 23560 H-InvDB: GTPBP4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GTPBP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GTPBP4 gene:
    Search GeneIP for patents involving GTPBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GTPBP4   OriGene RNAi products in human, mouse, rat for GTPBP4  
     OriGene qPCR primer pairs and template standards for GTPBP4   OriGene Protein Over-expression Lysate for GTPBP4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GTPBP4  
     OriGene qSTAR qPCR primer pairs in human, mouse for GTPBP4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GTPBP4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GTPBP4   OriGene Custom Protein Services for GTPBP4  

     
     
     Block miRNA regulation of human, mouse, rat GTPBP4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GTPBP4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTPBP4 Predesigned siRNA for gene silencing in human, mouse, rat GTPBP4
     QuantiFast Probe-based Assays in human, mouse, rat GTPBP4 QuantiTect SYBR Green Assays in human, mouse, rat GTPBP4
     Custom PCR Arrays for GTPBP4 Search Chromatin IP Primers for GTPBP4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTPBP4  GeneGlobe Interaction Network for GTPBP4
     Regulatory tfbs in GTPBP4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GTPBP4 GenScript cDNA clones with any tag delivered in your preferred vector for GTPBP4
     GenScript Custom Assay Services for GTPBP4 GenScript Custom overexpressing Cell Line Services for GTPBP4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GTPBP4 (NOG1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GTPBP4 antibodies
     GTPBP4 proteins
     GTPBP4 lysates
     Antibodies for GTPBP4
     See all of Abcam's Antibodies, Kits and Proteins for GTPBP4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GTPBP4
     Antibodies for GTPBP4
     ELISAs for GTPBP4
     CLIAs for GTPBP4



     Browse ESI BIO Cell Lines and PureStem Progenitors for GTPBP4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTPBP4
     SwitchGear 3'UTR luciferase reporter plasmids for GTPBP4
     SwitchGear Promoter luciferase reporter plasmids for GTPBP4
     ThermoFisher Antibodies for GTPBP4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTPBP4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTPBP4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTPBP4
     LSBio Antibodies in human, mouse, rat for GTPBP4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GTPBP4 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4