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Aliases for GTPBP4 Gene

Aliases for GTPBP4 Gene

  • GTP Binding Protein 4 2 3 5
  • Chronic Renal Failure Gene Protein 3 4
  • G Protein-Binding Protein CRFG 2 3
  • GTP-Binding Protein NGB 3 4
  • CRFG 3 4
  • NOG1 3 4
  • Nucleolar GTP-Binding Protein 1 3
  • GTP-Binding Protein 2
  • NGB 3

External Ids for GTPBP4 Gene

Previous GeneCards Identifiers for GTPBP4 Gene

  • GC10P001024
  • GC10P000973
  • GC10P001034

Summaries for GTPBP4 Gene

Entrez Gene Summary for GTPBP4 Gene

  • GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTPBP4 Gene

GTPBP4 (GTP Binding Protein 4) is a Protein Coding gene. Diseases associated with GTPBP4 include Commensal Bacterial Infectious Disease. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for GTPBP4 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit.

Gene Wiki entry for GTPBP4 Gene

Additional gene information for GTPBP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP4 Gene

Genomics for GTPBP4 Gene

Regulatory Elements for GTPBP4 Gene

Enhancers for GTPBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H000929 1.3 ENCODE dbSUPER 53.4 -57.1 -57090 3.8 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF766 GLIS2 ELK1 GTPBP4 LOC107984285 LARP4B LOC101927762 GC10P000921
GH10H000509 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -477.1 -477051 1.9 ELF3 PKNOX1 NFIB ARID4B SIN3A BMI1 ZNF2 BRCA1 RAD21 RFX5 GTPBP4 DIP2C ZMYND11 PIR53292 ENSG00000233021
GH10H000943 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -43.5 -43509 1.8 PKNOX1 JUN BACH1 BATF IKZF1 ZNF24 ZBTB33 RUNX3 IKZF2 MYC GTPBP4 IDI2-AS1 WDR37 PIR46180 LOC101927762
GH10H000983 1.1 ENCODE 14.9 -1.2 -1241 6.8 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 GTPBP4 DIP2C ZMYND11 LARP4B LOC101927762 WDR37 PIR35547
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTPBP4 on UCSC Golden Path with GeneCards custom track

Promoters for GTPBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023413 481 1801 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Locations for GTPBP4 Gene

Genomic Locations for GTPBP4 Gene
31,918 bases
Plus strand

Genomic View for GTPBP4 Gene

Genes around GTPBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP4 Gene

Proteins for GTPBP4 Gene

  • Protein details for GTPBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar GTP-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KMC5
    • B4DY13
    • B7Z7A3
    • O95446
    • Q5T3R8
    • Q9NVJ8

    Protein attributes for GTPBP4 Gene

    634 amino acids
    Molecular mass:
    73964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GTPBP4 Gene


neXtProt entry for GTPBP4 Gene

Post-translational modifications for GTPBP4 Gene

  • Ubiquitination at posLast=2525, isoforms=2103, posLast=118118, isoforms=2, 3145, and isoforms=2, 3181
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTPBP4 Gene

Domains & Families for GTPBP4 Gene

Gene Families for GTPBP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
genes like me logo Genes that share domains with GTPBP4: view

Function for GTPBP4 Gene

Molecular function for GTPBP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003924 GTPase activity IDA 17210637
GO:0005515 protein binding IPI 17210637
GO:0005525 GTP binding IDA 17210637
genes like me logo Genes that share ontologies with GTPBP4: view
genes like me logo Genes that share phenotypes with GTPBP4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTPBP4 Gene

Localization for GTPBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTPBP4 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17210637
GO:0005730 nucleolus IEA,IDA --
GO:0005737 cytoplasm IDA 17210637
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GTPBP4: view

Pathways & Interactions for GTPBP4 Gene

genes like me logo Genes that share pathways with GTPBP4: view

Pathways by source for GTPBP4 Gene

1 KEGG pathway for GTPBP4 Gene

Gene Ontology (GO) - Biological Process for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 17210637
GO:0001649 osteoblast differentiation IDA 16210410
GO:0008156 negative regulation of DNA replication IMP 17210637
GO:0008285 negative regulation of cell proliferation IMP 17210637
GO:0022408 negative regulation of cell-cell adhesion IDA 17210637
genes like me logo Genes that share ontologies with GTPBP4: view

No data available for SIGNOR curated interactions for GTPBP4 Gene

Drugs & Compounds for GTPBP4 Gene

(1) Drugs for GTPBP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GTPBP4: view

Transcripts for GTPBP4 Gene

Unigene Clusters for GTPBP4 Gene

GTP binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: - - - -
SP4: -

Relevant External Links for GTPBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTPBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTPBP4 Gene

Protein differential expression in normal tissues from HIPED for GTPBP4 Gene

This gene is overexpressed in Lung (19.0), Breast (8.9), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTPBP4 Gene

Protein tissue co-expression partners for GTPBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTPBP4 Gene:


SOURCE GeneReport for Unigene cluster for GTPBP4 Gene:


Evidence on tissue expression from TISSUES for GTPBP4 Gene

  • Kidney(4.5)
  • Nervous system(4.5)
  • Muscle(2.8)
  • Adrenal gland(2.6)
  • Heart(2.6)
  • Liver(2.5)
  • Blood(2.4)
  • Eye(2.3)
  • Lung(2.1)
  • Skin(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with GTPBP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTPBP4 Gene

Orthologs for GTPBP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTPBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTPBP4 33 34
  • 95.92 (n)
(Monodelphis domestica)
Mammalia GTPBP4 34
  • 90 (a)
(Mus musculus)
Mammalia Gtpbp4 33 16 34
  • 88.96 (n)
(Rattus norvegicus)
Mammalia Gtpbp4 33
  • 88.17 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
-- 34
  • 83 (a)
(Canis familiaris)
Mammalia GTPBP4 33 34
  • 86.41 (n)
(Bos Taurus)
Mammalia GTPBP4 33 34
  • 86.01 (n)
(Gallus gallus)
Aves GTPBP4 33 34
  • 78.55 (n)
(Anolis carolinensis)
Reptilia GTPBP4 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp4 33
  • 74.3 (n)
Str.2929 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24805 33
(Danio rerio)
Actinopterygii gtpbp4 33 34
  • 72.05 (n)
wufi28d07 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007050 33
  • 58.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8801 33 34
  • 58.76 (n)
(Caenorhabditis elegans)
Secernentea T07A9.9 33 34
  • 58.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR194W 33
  • 54.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24135g 33
  • 53.61 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOG1 34 36 33
  • 52.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10300 33
  • 56.52 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5831 33
(Oryza sativa)
Liliopsida Os07g0110200 33
  • 52.35 (n)
Os.14676 33
(Hordeum vulgare)
Liliopsida Hv.4238 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3484 34
  • 63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nog1 33
  • 54.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05289 33
  • 52.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9 33
Species where no ortholog for GTPBP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP4 Gene

Gene Tree for GTPBP4 (if available)
Gene Tree for GTPBP4 (if available)

Paralogs for GTPBP4 Gene

No data available for Paralogs for GTPBP4 Gene

Variants for GTPBP4 Gene

Sequence variations from dbSNP and Humsavar for GTPBP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000009560 -- 1,002,184(+) TCCCA(G/T)AGTGT intron-variant
rs1000057898 -- 993,665(+) AGGGC(A/G)TGGGG intron-variant
rs1000206510 -- 1,009,370(+) CGCAG(A/G)CAGGG intron-variant
rs1000240402 -- 987,970(+) ATCTG(C/T)TCCAC nc-transcript-variant, upstream-variant-2KB
rs1000290729 -- 999,386(+) AAAGT(C/G)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP4 Gene

Variant ID Type Subtype PubMed ID
nsv549765 CNV gain 21841781
nsv1161921 CNV duplication 26073780
nsv1150353 CNV deletion 26484159
nsv1137862 CNV deletion 24896259
nsv1137365 CNV deletion 24896259
nsv1133144 CNV tandem duplication 24896259
nsv1125172 CNV insertion 24896259
nsv1124337 CNV deletion 24896259
nsv1068262 CNV deletion 25765185
esv3891735 CNV gain 25118596
esv3545708 CNV deletion 23714750
esv2729339 CNV deletion 23290073
esv2729328 CNV deletion 23290073
esv2729306 CNV deletion 23290073
esv2729295 CNV deletion 23290073
esv2729284 CNV deletion 23290073
esv2729273 CNV deletion 23290073
esv2729262 CNV deletion 23290073
esv2729251 CNV deletion 23290073
esv2729239 CNV deletion 23290073
esv2660097 CNV deletion 23128226
esv2551854 CNV insertion 19546169
esv24871 CNV gain 19812545
esv1989555 CNV deletion 18987734
esv1468754 CNV insertion 17803354
esv1067888 CNV deletion 17803354
dgv74e201 CNV deletion 23290073

Variation tolerance for GTPBP4 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTPBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP4 Gene

Disorders for GTPBP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTPBP4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
commensal bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GTPBP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GTPBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTPBP4 Gene

Publications for GTPBP4 Gene

  1. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. (PMID: 11316846) Laping NJ … Zhu Y (Journal of the American Society of Nephrology : JASN 2001) 2 3 4 60
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for GTPBP4 Gene

Sources for GTPBP4 Gene

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