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Aliases for GTPBP4 Gene

Aliases for GTPBP4 Gene

  • GTP Binding Protein 4 2 3 5
  • Chronic Renal Failure Gene Protein 3 4
  • G Protein-Binding Protein CRFG 2 3
  • GTP-Binding Protein NGB 3 4
  • CRFG 3 4
  • NOG1 3 4
  • GTP-Binding Protein 2
  • NGB 3

External Ids for GTPBP4 Gene

Previous GeneCards Identifiers for GTPBP4 Gene

  • GC10P001024
  • GC10P000973
  • GC10P001034

Summaries for GTPBP4 Gene

Entrez Gene Summary for GTPBP4 Gene

  • GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTPBP4 Gene

GTPBP4 (GTP Binding Protein 4) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for GTPBP4 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit.

Gene Wiki entry for GTPBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP4 Gene

Genomics for GTPBP4 Gene

Regulatory Elements for GTPBP4 Gene

Enhancers for GTPBP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTPBP4 on UCSC Golden Path with GeneCards custom track

Promoters for GTPBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTPBP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTPBP4 Gene

Chromosome:
10
Start:
988,019 bp from pter
End:
1,019,936 bp from pter
Size:
31,918 bases
Orientation:
Plus strand

Genomic View for GTPBP4 Gene

Genes around GTPBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP4 Gene

Proteins for GTPBP4 Gene

  • Protein details for GTPBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE4-NOG1_HUMAN
    Recommended name:
    Nucleolar GTP-binding protein 1
    Protein Accession:
    Q9BZE4
    Secondary Accessions:
    • B3KMC5
    • B4DY13
    • B7Z7A3
    • O95446
    • Q5T3R8
    • Q9NVJ8

    Protein attributes for GTPBP4 Gene

    Size:
    634 amino acids
    Molecular mass:
    73964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GTPBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTPBP4 Gene

Proteomics data for GTPBP4 Gene at MOPED

Post-translational modifications for GTPBP4 Gene

  • Ubiquitination at Lys 25, Lys 103, Lys 118, Lys 145, and Lys 181
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GTPBP4 Gene

Domains & Families for GTPBP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZE4

UniProtKB/Swiss-Prot:

NOG1_HUMAN :
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
Domain:
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
genes like me logo Genes that share domains with GTPBP4: view

No data available for Gene Families for GTPBP4 Gene

Function for GTPBP4 Gene

Molecular function for GTPBP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17210637
genes like me logo Genes that share ontologies with GTPBP4: view
genes like me logo Genes that share phenotypes with GTPBP4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTPBP4 Gene

Localization for GTPBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTPBP4 Gene COMPARTMENTS Subcellular localization image for GTPBP4 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17210637
genes like me logo Genes that share ontologies with GTPBP4: view

Pathways & Interactions for GTPBP4 Gene

genes like me logo Genes that share pathways with GTPBP4: view

Pathways by source for GTPBP4 Gene

1 KEGG pathway for GTPBP4 Gene

Gene Ontology (GO) - Biological Process for GTPBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 17210637
GO:0030336 negative regulation of cell migration IDA 17210637
GO:0033342 negative regulation of collagen binding IMP 17210637
genes like me logo Genes that share ontologies with GTPBP4: view

No data available for SIGNOR curated interactions for GTPBP4 Gene

Drugs & Compounds for GTPBP4 Gene

(1) Drugs for GTPBP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GTPBP4: view

Transcripts for GTPBP4 Gene

Unigene Clusters for GTPBP4 Gene

GTP binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: - - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for GTPBP4 Gene

GeneLoc Exon Structure for
GTPBP4
ECgene alternative splicing isoforms for
GTPBP4

Expression for GTPBP4 Gene

mRNA expression in normal human tissues for GTPBP4 Gene

Protein differential expression in normal tissues from HIPED for GTPBP4 Gene

This gene is overexpressed in Lung (19.0), Breast (8.9), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTPBP4 Gene



SOURCE GeneReport for Unigene cluster for GTPBP4 Gene Hs.215766

genes like me logo Genes that share expression patterns with GTPBP4: view

Protein tissue co-expression partners for GTPBP4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTPBP4 Gene

Orthologs for GTPBP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTPBP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTPBP4 35
  • 86.01 (n)
  • 93.85 (a)
GTPBP4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTPBP4 35
  • 86.41 (n)
  • 93.85 (a)
GTPBP4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtpbp4 35
  • 88.96 (n)
  • 94.79 (a)
Gtpbp4 16
Gtpbp4 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTPBP4 35
  • 95.92 (n)
  • 95.49 (a)
GTPBP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtpbp4 35
  • 88.17 (n)
  • 94.95 (a)
oppossum
(Monodelphis domestica)
Mammalia GTPBP4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves GTPBP4 35
  • 78.55 (n)
  • 86.53 (a)
GTPBP4 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTPBP4 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp4 35
  • 74.3 (n)
  • 83.1 (a)
Str.2929 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24805 35
zebrafish
(Danio rerio)
Actinopterygii gtpbp4 35
  • 72.05 (n)
  • 82.88 (a)
wufi28d07 35
gtpbp4 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007050 35
  • 58.93 (n)
  • 60.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8801 35
  • 58.76 (n)
  • 60.92 (a)
CG8801 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T07A9.9 35
  • 58.4 (n)
  • 58.29 (a)
T07A9.9 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR194W 35
  • 54.31 (n)
  • 48.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24135g 35
  • 53.61 (n)
  • 47.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOG1 35
  • 52.52 (n)
  • 47.38 (a)
NOG1 36
  • 46 (a)
OneToOne
NOG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10300 35
  • 56.52 (n)
  • 54.5 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5831 35
barley
(Hordeum vulgare)
Liliopsida Hv.4238 35
rice
(Oryza sativa)
Liliopsida Os.14676 35
Os07g0110200 35
  • 52.35 (n)
  • 45.25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05289 35
  • 52.71 (n)
  • 52.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nog1 35
  • 54.85 (n)
  • 54.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3484 36
  • 63 (a)
OneToOne
Species with no ortholog for GTPBP4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP4 Gene

ENSEMBL:
Gene Tree for GTPBP4 (if available)
TreeFam:
Gene Tree for GTPBP4 (if available)

Paralogs for GTPBP4 Gene

No data available for Paralogs for GTPBP4 Gene

Variants for GTPBP4 Gene

Sequence variations from dbSNP and Humsavar for GTPBP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3207775 - 1,014,278(+) GATGC(A/G)TAGTC reference, missense
rs14585 -- 1,017,534(-) GAAAA(A/T)AAGGT utr-variant-3-prime
rs1802507 -- 1,017,571(+) TTTAT(G/T)AGTGT utr-variant-3-prime
rs1871621 -- 1,003,656(-) ATGGA(A/G)GTGAG intron-variant
rs1871622 -- 1,003,369(-) ttcaa(A/C)ataat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP4 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
esv2551854 CNV Insertion 19546169
esv2729239 CNV Deletion 23290073
esv2729251 CNV Deletion 23290073
esv2729262 CNV Deletion 23290073
esv24871 CNV Gain 19812545
esv1067888 CNV Deletion 17803354
esv2729273 CNV Deletion 23290073
esv2729284 CNV Deletion 23290073
esv2729295 CNV Deletion 23290073
esv2729306 CNV Deletion 23290073
esv1468754 CNV Insertion 17803354
dgv589n71 CNV Loss 21882294
dgv86e201 CNV Deletion 23290073
esv1989555 CNV Deletion 18987734
esv2729328 CNV Deletion 23290073
esv2729339 CNV Deletion 23290073

Variation tolerance for GTPBP4 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GTPBP4 Gene

Disorders for GTPBP4 Gene

Relevant External Links for GTPBP4

Genetic Association Database (GAD)
GTPBP4
Human Genome Epidemiology (HuGE) Navigator
GTPBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTPBP4

No disorders were found for GTPBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTPBP4 Gene

Publications for GTPBP4 Gene

  1. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. (PMID: 11316846) Laping N.J. … Zhu Y. (J. Am. Soc. Nephrol. 2001) 2 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GTPBP4 Gene

Sources for GTPBP4 Gene

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