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Aliases for GTPBP10 Gene

Aliases for GTPBP10 Gene

  • GTP Binding Protein 10 2 3 5
  • Protein Obg Homolog 2 3 4
  • ObgH2 3 4
  • GTP-Binding Protein 10 (Putative) 2
  • GTP Binding Protein 10 (Putative) 3
  • GTP-Binding Protein 10 3
  • UG0751c10 3

External Ids for GTPBP10 Gene

Previous GeneCards Identifiers for GTPBP10 Gene

  • GC07P089813
  • GC07P089964
  • GC07P084585

Summaries for GTPBP10 Gene

Entrez Gene Summary for GTPBP10 Gene

  • Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GTPBP10 Gene

GTPBP10 (GTP Binding Protein 10) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is MTG2.

UniProtKB/Swiss-Prot for GTPBP10 Gene

  • May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP10 Gene

Genomics for GTPBP10 Gene

Regulatory Elements for GTPBP10 Gene

Enhancers for GTPBP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F090402 1.4 FANTOM5 ENCODE 16.5 +68.9 68898 3.0 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ZNF263 SP3 GTPBP10 STEAP1 ENSG00000234459 FZD1 STEAP2 ENSG00000273299 GC07P090415
GH07F090345 1.1 ENCODE 14 +11.5 11501 2.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 STEAP1 GTPBP10 STEAP2 ENSG00000234459 FZD1 ENSG00000280440 CLDN12
GH07F090620 1.4 FANTOM5 Ensembl ENCODE 7.4 +288.5 288503 6.2 ZNF146 JUN TEAD4 ZNF384 RAD21 POLR2A ZNF366 EED RCOR1 ETV6 ENSG00000223969 CDK14 ENSG00000251154 CLDN12 GTPBP10 STEAP2 TVP23CP1 GC07P090613
GH07F090382 0.6 Ensembl ENCODE 15.1 +48.7 48657 2.5 JUND STEAP2 GTPBP10 CLDN12 GC07P090388
GH07F090222 0.9 Ensembl ENCODE 9.7 -112.1 -112129 1.1 SOX13 NFIA MTA2 CEBPB TBX21 CEBPA IKZF1 NBN STEAP2 CFAP69 ENSG00000207488 GTPBP10 GC07P090219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTPBP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTPBP10 Gene

Chromosome:
7
Start:
90,335,223 bp from pter
End:
90,391,455 bp from pter
Size:
56,233 bases
Orientation:
Plus strand

Genomic View for GTPBP10 Gene

Genes around GTPBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP10 Gene

Proteins for GTPBP10 Gene

  • Protein details for GTPBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1E9-GTPBA_HUMAN
    Recommended name:
    GTP-binding protein 10
    Protein Accession:
    A4D1E9
    Secondary Accessions:
    • B4DFY6
    • Q3B7A6
    • Q5H9V2
    • Q8IXG8
    • Q8N982
    • Q8WU16
    • Q9BSP1
    • Q9Y6T6

    Protein attributes for GTPBP10 Gene

    Size:
    387 amino acids
    Molecular mass:
    42933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GTPBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTPBP10 Gene

Post-translational modifications for GTPBP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTPBP10 Gene

Domains & Families for GTPBP10 Gene

Protein Domains for GTPBP10 Gene

Suggested Antigen Peptide Sequences for GTPBP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1E9

UniProtKB/Swiss-Prot:

GTPBA_HUMAN :
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Domain:
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with GTPBP10: view

No data available for Gene Families for GTPBP10 Gene

Function for GTPBP10 Gene

Molecular function for GTPBP10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed.

Gene Ontology (GO) - Molecular Function for GTPBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GTPBP10: view

Phenotypes for GTPBP10 Gene

GenomeRNAi human phenotypes for GTPBP10:
genes like me logo Genes that share phenotypes with GTPBP10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTPBP10 Gene

Localization for GTPBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP10 Gene

Nucleus, nucleolus. Chromosome. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTPBP10 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for GTPBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GTPBP10: view

Pathways & Interactions for GTPBP10 Gene

SuperPathways for GTPBP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GTPBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with GTPBP10: view

No data available for Pathways by source and SIGNOR curated interactions for GTPBP10 Gene

Drugs & Compounds for GTPBP10 Gene

(1) Drugs for GTPBP10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GTPBP10: view

Transcripts for GTPBP10 Gene

Unigene Clusters for GTPBP10 Gene

GTP-binding protein 10 (putative):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP10 Gene

No ASD Table

Relevant External Links for GTPBP10 Gene

GeneLoc Exon Structure for
GTPBP10
ECgene alternative splicing isoforms for
GTPBP10

Expression for GTPBP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTPBP10 Gene

Protein differential expression in normal tissues from HIPED for GTPBP10 Gene

This gene is overexpressed in Lung (36.9) and Hair follicle (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTPBP10 Gene



NURSA nuclear receptor signaling pathways regulating expression of GTPBP10 Gene:

GTPBP10

SOURCE GeneReport for Unigene cluster for GTPBP10 Gene:

Hs.709271
genes like me logo Genes that share expression patterns with GTPBP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GTPBP10 Gene

Orthologs for GTPBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTPBP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTPBP10 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia GTPBP10 34 35
  • 90.51 (n)
cow
(Bos Taurus)
Mammalia GTPBP10 34 35
  • 90.07 (n)
rat
(Rattus norvegicus)
Mammalia Gtpbp10 34
  • 85.73 (n)
mouse
(Mus musculus)
Mammalia Gtpbp10 34 16 35
  • 84.84 (n)
oppossum
(Monodelphis domestica)
Mammalia GTPBP10 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves GTPBP10 34 35
  • 72.51 (n)
lizard
(Anolis carolinensis)
Reptilia GTPBP10 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp10 34
  • 65.65 (n)
zebrafish
(Danio rerio)
Actinopterygii gtpbp10 34 35
  • 63.26 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10421 34
fruit fly
(Drosophila melanogaster)
Insecta CG10628 34 35
  • 50.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008337 34
  • 49.53 (n)
worm
(Caenorhabditis elegans)
Secernentea C26E6.12 34 35
  • 50.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG2 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for GTPBP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP10 Gene

ENSEMBL:
Gene Tree for GTPBP10 (if available)
TreeFam:
Gene Tree for GTPBP10 (if available)

Paralogs for GTPBP10 Gene

Paralogs for GTPBP10 Gene

(1) SIMAP similar genes for GTPBP10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GTPBP10: view

Variants for GTPBP10 Gene

Sequence variations from dbSNP and Humsavar for GTPBP10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10228776 -- 90,374,250(+) AGAGT(A/C)CCAGC intron-variant
rs10229749 -- 90,391,644(+) AGCAG(A/G)TGATA downstream-variant-500B
rs10230122 -- 90,391,939(+) GGAGC(A/G)GGTAG downstream-variant-500B
rs10231207 -- 90,379,793(+) catca(A/T)tgtat intron-variant
rs10235104 -- 90,350,533(+) tggca(A/G)ttaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP10 Gene

Variant ID Type Subtype PubMed ID
nsv607785 CNV loss 21841781
nsv1125918 CNV tandem duplication 24896259
esv3891163 CNV loss 25118596
esv24241 CNV loss 19812545

Variation tolerance for GTPBP10 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTPBP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTPBP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP10 Gene

Disorders for GTPBP10 Gene

Relevant External Links for GTPBP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTPBP10

No disorders were found for GTPBP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTPBP10 Gene

Publications for GTPBP10 Gene

  1. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. (PMID: 17054726) Hirano Y. … Takeyasu K. (Genes Cells 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for GTPBP10 Gene

Sources for GTPBP10 Gene

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