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Aliases for GTPBP10 Gene

Aliases for GTPBP10 Gene

  • GTP Binding Protein 10 2 3 5
  • Protein Obg Homolog 2 3 4
  • ObgH2 3 4
  • GTP-Binding Protein 10 (Putative) 2
  • GTP Binding Protein 10 (Putative) 3
  • GTP-Binding Protein 10 3
  • UG0751c10 3

External Ids for GTPBP10 Gene

Previous GeneCards Identifiers for GTPBP10 Gene

  • GC07P089813
  • GC07P089964
  • GC07P084585

Summaries for GTPBP10 Gene

Entrez Gene Summary for GTPBP10 Gene

  • Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GTPBP10 Gene

GTPBP10 (GTP Binding Protein 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is MTG2.

UniProtKB/Swiss-Prot for GTPBP10 Gene

  • May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.

Additional gene information for GTPBP10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP10 Gene

Genomics for GTPBP10 Gene

GeneHancer (GH) Regulatory Elements for GTPBP10 Gene

Promoters and enhancers for GTPBP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I090345 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564 +11.5 11501 2.7 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 GTPBP10 PIR48694 ENSG00000280440 STEAP1 STEAP2 ENSG00000234459 CLDN12
GH07I091263 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.7 +930.4 930413 5.2 PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 CBX5 FZD1 KRIT1 ENSG00000243107 GTPBP10 ENSG00000234459 AKAP9 LOC105375392
GH07I090402 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 16.5 +68.9 68898 3 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 ENSG00000273299 CLDN12 GTPBP10 STEAP2 GC07P090415
GH07I090244 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 -89.7 -89656 2 FOXA2 SMAD1 ARID4B NEUROD1 SIN3A ZNF2 IRF4 YY1 ZNF207 ZNF143 CFAP69 STEAP2 GTPBP10 STEAP1 GC07P090252
GH07I090463 Promoter/Enhancer 1 Ensembl ENCODE 13.5 +128.3 128333 0.7 IRF2 MAX HNF4A ZNF644 PRDM1 YY1 GTPBP10 CDK14 GC07M090434 ENSG00000273299 CLDN12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GTPBP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTPBP10 gene promoter:

Genomic Locations for GTPBP10 Gene

Genomic Locations for GTPBP10 Gene
chr7:90,335,223-90,391,455
(GRCh38/hg38)
Size:
56,233 bases
Orientation:
Plus strand
chr7:89,964,537-90,020,769
(GRCh37/hg19)

Genomic View for GTPBP10 Gene

Genes around GTPBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP10 Gene

Proteins for GTPBP10 Gene

  • Protein details for GTPBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1E9-GTPBA_HUMAN
    Recommended name:
    GTP-binding protein 10
    Protein Accession:
    A4D1E9
    Secondary Accessions:
    • B4DFY6
    • Q3B7A6
    • Q5H9V2
    • Q8IXG8
    • Q8N982
    • Q8WU16
    • Q9BSP1
    • Q9Y6T6

    Protein attributes for GTPBP10 Gene

    Size:
    387 amino acids
    Molecular mass:
    42933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GTPBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTPBP10 Gene

Post-translational modifications for GTPBP10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GTPBP10 Gene

Domains & Families for GTPBP10 Gene

Gene Families for GTPBP10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for GTPBP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1E9

UniProtKB/Swiss-Prot:

GTPBA_HUMAN :
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with GTPBP10: view

Function for GTPBP10 Gene

Molecular function for GTPBP10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.

Gene Ontology (GO) - Molecular Function for GTPBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GTPBP10: view

Phenotypes for GTPBP10 Gene

GenomeRNAi human phenotypes for GTPBP10:
genes like me logo Genes that share phenotypes with GTPBP10: view

Animal Model Products

miRNA for GTPBP10 Gene

miRTarBase miRNAs that target GTPBP10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTPBP10 Gene

Localization for GTPBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP10 Gene

Nucleus, nucleolus. Chromosome. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTPBP10 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for GTPBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GTPBP10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GTPBP10 Gene

Pathways & Interactions for GTPBP10 Gene

SuperPathways for GTPBP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GTPBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with GTPBP10: view

No data available for Pathways by source and SIGNOR curated interactions for GTPBP10 Gene

Drugs & Compounds for GTPBP10 Gene

(1) Drugs for GTPBP10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GTPBP10: view

Transcripts for GTPBP10 Gene

Unigene Clusters for GTPBP10 Gene

GTP-binding protein 10 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP10 Gene

No ASD Table

Relevant External Links for GTPBP10 Gene

GeneLoc Exon Structure for
GTPBP10
ECgene alternative splicing isoforms for
GTPBP10

Expression for GTPBP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTPBP10 Gene

Protein differential expression in normal tissues from HIPED for GTPBP10 Gene

This gene is overexpressed in Lung (36.9) and Hair follicle (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTPBP10 Gene



NURSA nuclear receptor signaling pathways regulating expression of GTPBP10 Gene:

GTPBP10

SOURCE GeneReport for Unigene cluster for GTPBP10 Gene:

Hs.709271

Evidence on tissue expression from TISSUES for GTPBP10 Gene

  • Nervous system(4.4)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with GTPBP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTPBP10 Gene

Orthologs for GTPBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTPBP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTPBP10 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia GTPBP10 33 34
  • 90.51 (n)
cow
(Bos Taurus)
Mammalia GTPBP10 33 34
  • 90.07 (n)
rat
(Rattus norvegicus)
Mammalia Gtpbp10 33
  • 85.73 (n)
mouse
(Mus musculus)
Mammalia Gtpbp10 33 16 34
  • 84.84 (n)
oppossum
(Monodelphis domestica)
Mammalia GTPBP10 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves GTPBP10 33 34
  • 72.51 (n)
lizard
(Anolis carolinensis)
Reptilia GTPBP10 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp10 33
  • 65.65 (n)
zebrafish
(Danio rerio)
Actinopterygii gtpbp10 33 34
  • 63.26 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10421 33
fruit fly
(Drosophila melanogaster)
Insecta CG10628 33 34
  • 50.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008337 33
  • 49.53 (n)
worm
(Caenorhabditis elegans)
Secernentea C26E6.12 33 34
  • 50.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG2 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for GTPBP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP10 Gene

ENSEMBL:
Gene Tree for GTPBP10 (if available)
TreeFam:
Gene Tree for GTPBP10 (if available)

Paralogs for GTPBP10 Gene

Paralogs for GTPBP10 Gene

(1) SIMAP similar genes for GTPBP10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GTPBP10: view

Variants for GTPBP10 Gene

Sequence variations from dbSNP and Humsavar for GTPBP10 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000003266 -- 90,370,153(+) C/T intron_variant
rs1000111796 -- 90,376,533(+) C/T intron_variant
rs1000235077 -- 90,348,850(+) A/G intron_variant
rs1000253799 -- 90,355,136(+) G/C coding_sequence_variant, intron_variant, missense_variant
rs1000264669 -- 90,379,824(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP10 Gene

Variant ID Type Subtype PubMed ID
esv24241 CNV loss 19812545
esv3891163 CNV loss 25118596
nsv1125918 CNV tandem duplication 24896259
nsv607785 CNV loss 21841781

Variation tolerance for GTPBP10 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTPBP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTPBP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP10 Gene

Disorders for GTPBP10 Gene

Additional Disease Information for GTPBP10

No disorders were found for GTPBP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTPBP10 Gene

Publications for GTPBP10 Gene

  1. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. (PMID: 17054726) Hirano Y … Takeyasu K (Genes to cells : devoted to molecular & cellular mechanisms 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. (PMID: 27667664) Arroyo JD … Mootha VK (Cell metabolism 2016) 3 58

Products for GTPBP10 Gene

Sources for GTPBP10 Gene

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