Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GTPBP1 Gene

Aliases for GTPBP1 Gene

  • GTP Binding Protein 1 2 3 5
  • G-Protein 1 3 4
  • GP-1 3 4
  • GP1 3 4
  • HSPC018 3

External Ids for GTPBP1 Gene

Previous GeneCards Identifiers for GTPBP1 Gene

  • GC22P035716
  • GC22P037345
  • GC22P037426
  • GC22P039101
  • GC22P022067

Summaries for GTPBP1 Gene

Entrez Gene Summary for GTPBP1 Gene

  • This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTPBP1 Gene

GTPBP1 (GTP Binding Protein 1) is a Protein Coding gene. Diseases associated with GTPBP1 include Lassa Fever. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GTPBP2.

UniProtKB/Swiss-Prot for GTPBP1 Gene

  • Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).

Gene Wiki entry for GTPBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP1 Gene

Genomics for GTPBP1 Gene

Regulatory Elements for GTPBP1 Gene

Enhancers for GTPBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTPBP1 on UCSC Golden Path with GeneCards custom track

Promoters for GTPBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTPBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTPBP1 Gene

Chromosome:
22
Start:
38,704,557 bp from pter
End:
38,738,299 bp from pter
Size:
33,743 bases
Orientation:
Plus strand

Genomic View for GTPBP1 Gene

Genes around GTPBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP1 Gene

Proteins for GTPBP1 Gene

  • Protein details for GTPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00178-GTPB1_HUMAN
    Recommended name:
    GTP-binding protein 1
    Protein Accession:
    O00178
    Secondary Accessions:
    • Q6IC67

    Protein attributes for GTPBP1 Gene

    Size:
    669 amino acids
    Molecular mass:
    72454 Da
    Quaternary structure:
    • Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).
    SequenceCaution:
    • Sequence=AAB51273.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30387.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GTPBP1 Gene

Proteomics data for GTPBP1 Gene at MOPED

Post-translational modifications for GTPBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTPBP1 Gene

Domains & Families for GTPBP1 Gene

Suggested Antigen Peptide Sequences for GTPBP1 Gene

Graphical View of Domain Structure for InterPro Entry

O00178

UniProtKB/Swiss-Prot:

GTPB1_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
genes like me logo Genes that share domains with GTPBP1: view

No data available for Gene Families for GTPBP1 Gene

Function for GTPBP1 Gene

Molecular function for GTPBP1 Gene

GENATLAS Biochemistry:
GTP binding protein 1
UniProtKB/Swiss-Prot Function:
Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
genes like me logo Genes that share phenotypes with GTPBP1: view

Animal Models for GTPBP1 Gene

MGI Knock Outs for GTPBP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTPBP1 Gene

Localization for GTPBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTPBP1 Gene COMPARTMENTS Subcellular localization image for GTPBP1 gene
Compartment Confidence
cytosol 5
endosome 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GTPBP1 Gene

Pathways & Interactions for GTPBP1 Gene

SuperPathways for GTPBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GTPBP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GTPBP1 Gene

Drugs & Compounds for GTPBP1 Gene

(1) Drugs for GTPBP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GTPBP1: view

Transcripts for GTPBP1 Gene

Unigene Clusters for GTPBP1 Gene

GTP binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for GTPBP1 Gene

GeneLoc Exon Structure for
GTPBP1
ECgene alternative splicing isoforms for
GTPBP1

Expression for GTPBP1 Gene

mRNA expression in normal human tissues for GTPBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GTPBP1 Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for GTPBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.2) and Breast (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTPBP1 Gene



SOURCE GeneReport for Unigene cluster for GTPBP1 Gene Hs.276925

genes like me logo Genes that share expression patterns with GTPBP1: view

Protein tissue co-expression partners for GTPBP1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GTPBP1 Gene

Orthologs for GTPBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTPBP1 35
  • 93.5 (n)
  • 99.65 (a)
GTPBP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTPBP1 35
  • 93.07 (n)
  • 98.36 (a)
GTPBP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtpbp1 35
  • 90.72 (n)
  • 97.31 (a)
Gtpbp1 16
Gtpbp1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTPBP1 35
  • 99.85 (n)
  • 100 (a)
GTPBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtpbp1 35
  • 91.78 (n)
  • 97.31 (a)
oppossum
(Monodelphis domestica)
Mammalia GTPBP1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTPBP1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTPBP1 35
  • 81.53 (n)
  • 92.47 (a)
GTPBP1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTPBP1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp1 35
  • 75.43 (n)
  • 87.94 (a)
Str.19499 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14724 35
zebrafish
(Danio rerio)
Actinopterygii gtpbp1 35
  • 74.23 (n)
  • 85.38 (a)
wufb36e06 35
gtpbp1 36
  • 80 (a)
OneToMany
gtpbp1l 36
  • 78 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9562 35
fruit fly
(Drosophila melanogaster)
Insecta Dgp-1 37
  • 71 (a)
Dgp-1 35
  • 66.04 (n)
  • 69.72 (a)
Dgp-1 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005227 35
  • 64.91 (n)
  • 70.67 (a)
worm
(Caenorhabditis elegans)
Secernentea cgp-1 35
  • 55.02 (n)
  • 57.06 (a)
cgp-1 36
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4464 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09513 35
  • 56.11 (n)
  • 51.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5638 36
  • 70 (a)
OneToOne
Species with no ortholog for GTPBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP1 Gene

ENSEMBL:
Gene Tree for GTPBP1 (if available)
TreeFam:
Gene Tree for GTPBP1 (if available)

Paralogs for GTPBP1 Gene

Paralogs for GTPBP1 Gene

(1) SIMAP similar genes for GTPBP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GTPBP1: view

Variants for GTPBP1 Gene

Sequence variations from dbSNP and Humsavar for GTPBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs11547402 - 38,708,923(+) GATGC(C/G)GAGAG intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs2179144 -- 38,711,195(+) atgat(A/T)ccttc intron-variant
rs2235229 -- 38,728,907(+) AGTTA(C/T)TTCTG intron-variant
rs2235230 -- 38,728,462(+) GGTTC(C/T)TATGG intron-variant
rs2267393 -- 38,705,614(+) AGTCA(C/G)ACACT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GTPBP1 Gene

Variant ID Type Subtype PubMed ID
nsv915067 CNV Loss 21882294
nsv915068 CNV Loss 21882294
dgv769n67 CNV Gain 20364138
esv991516 CNV Deletion 20482838

Variation tolerance for GTPBP1 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GTPBP1 Gene

Disorders for GTPBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTPBP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lassa fever
  • lf
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GTPBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTPBP1
genes like me logo Genes that share disorders with GTPBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTPBP1 Gene

Publications for GTPBP1 Gene

  1. Identification of human and mouse GP-1, a putative member of a novel G-protein family. (PMID: 9070279) Senju S. … Nishimura Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. (PMID: 10833435) Kudo H. … Nishimura Y. (Biochem. Biophys. Res. Commun. 2000) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for GTPBP1 Gene

Sources for GTPBP1 Gene

Content