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Aliases for GTPBP1 Gene

Aliases for GTPBP1 Gene

  • GTP Binding Protein 1 2 3
  • GP1 3 4 6
  • G-Protein 1 3 4
  • GP-1 3 4
  • GTP-Binding Protein 1 3
  • HSPC018 3

External Ids for GTPBP1 Gene

Summaries for GTPBP1 Gene

Entrez Gene Summary for GTPBP1 Gene

  • This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTPBP1 Gene

GTPBP1 (GTP Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GTPBP2.

UniProtKB/Swiss-Prot for GTPBP1 Gene

  • Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).

Gene Wiki entry for GTPBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP1 Gene

Genomics for GTPBP1 Gene

Genomic Location for GTPBP1 Gene

Start:
38,705,723 bp from pter
End:
38,738,299 bp from pter
Size:
32,577 bases
Orientation:
Plus strand

Genomic View for GTPBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP1 Gene

Regulatory Elements for GTPBP1 Gene

Proteins for GTPBP1 Gene

  • Protein details for GTPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00178-GTPB1_HUMAN
    Recommended name:
    GTP-binding protein 1
    Protein Accession:
    O00178
    Secondary Accessions:
    • Q6IC67

    Protein attributes for GTPBP1 Gene

    Size:
    669 amino acids
    Molecular mass:
    72454 Da
    Quaternary structure:
    • Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).
    SequenceCaution:
    • Sequence=AAB51273.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30387.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GTPBP1 Gene

Proteomics data for GTPBP1 Gene at MOPED

Post-translational modifications for GTPBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTPBP1 Gene

Domains for GTPBP1 Gene

Suggested Antigen Peptide Sequences for GTPBP1 Gene

Graphical View of Domain Structure for InterPro Entry

O00178

UniProtKB/Swiss-Prot:

GTPB1_HUMAN
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.:
    • O00178
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.:
    • O00178
genes like me logo Genes that share domains with GTPBP1: view

No data available for Gene Families for GTPBP1 Gene

Function for GTPBP1 Gene

Molecular function for GTPBP1 Gene

GENATLAS Biochemistry: GTP binding protein 1
UniProtKB/Swiss-Prot Function: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).

Gene Ontology (GO) - Molecular Function for GTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity ISS --
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GTPBP1: view

Phenotypes for GTPBP1 Gene

MGI mutant phenotypes for GTPBP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with GTPBP1: view

Animal Models for GTPBP1 Gene

MGI Knock Outs for GTPBP1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GTPBP1 Gene

Localization for GTPBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTPBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTPBP1 Gene COMPARTMENTS Subcellular localization image for GTPBP1 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000177 cytoplasmic exosome (RNase complex) ISS --
GO:0005829 cytosol ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GTPBP1: view

Pathways for GTPBP1 Gene

SuperPathways for GTPBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006955 immune response TAS 9070279
GO:0007165 signal transduction TAS 9070279
GO:0008152 metabolic process ISS --
GO:0061014 positive regulation of mRNA catabolic process ISS --
genes like me logo Genes that share ontologies with GTPBP1: view

No data available for Pathways by source for GTPBP1 Gene

Compounds for GTPBP1 Gene

(1) HMDB Compounds for GTPBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GTPBP1: view

Transcripts for GTPBP1 Gene

Unigene Clusters for GTPBP1 Gene

GTP binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for GTPBP1 Gene

GeneLoc Exon Structure for
GTPBP1
ECgene alternative splicing isoforms for
GTPBP1

Expression for GTPBP1 Gene

mRNA expression in normal human tissues for GTPBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GTPBP1 Gene

This gene is overexpressed in Whole Blood (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTPBP1 Gene

SOURCE GeneReport for Unigene cluster for GTPBP1 Gene Hs.276925

genes like me logo Genes that share expressions with GTPBP1: view

No data available for mRNA Expression by UniProt/SwissProt for GTPBP1 Gene

Orthologs for GTPBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTPBP1 35
  • 99.85 (n)
  • 100 (a)
GTPBP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTPBP1 35
  • 93.5 (n)
  • 99.65 (a)
GTPBP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTPBP1 35
  • 93.07 (n)
  • 98.36 (a)
GTPBP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtpbp1 35
  • 90.72 (n)
  • 97.31 (a)
Gtpbp1 16
Gtpbp1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTPBP1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTPBP1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtpbp1 35
  • 91.78 (n)
  • 97.31 (a)
chicken
(Gallus gallus)
Aves GTPBP1 35
  • 81.53 (n)
  • 92.47 (a)
GTPBP1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTPBP1 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14724 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp1 35
  • 75.43 (n)
  • 87.94 (a)
Str.19499 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9562 35
zebrafish
(Danio rerio)
Actinopterygii gtpbp1 35
  • 74.23 (n)
  • 85.38 (a)
gtpbp1 36
  • 80 (a)
OneToMany
gtpbp1l 36
  • 78 (a)
OneToMany
wufb36e06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005227 35
  • 64.91 (n)
  • 70.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dgp-1 35
  • 66.04 (n)
  • 69.72 (a)
Dgp-1 36
  • 59 (a)
OneToOne
Dgp-1 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea cgp-1 35
  • 55.02 (n)
  • 57.06 (a)
cgp-1 36
  • 50 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09513 35
  • 56.11 (n)
  • 51.88 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4464 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5638 36
  • 70 (a)
OneToOne
Species with no ortholog for GTPBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP1 Gene

ENSEMBL:
Gene Tree for GTPBP1 (if available)
TreeFam:
Gene Tree for GTPBP1 (if available)

Paralogs for GTPBP1 Gene

Paralogs for GTPBP1 Gene

Selected SIMAP similar genes for GTPBP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GTPBP1: view

Variants for GTPBP1 Gene

Sequence variations from dbSNP and Humsavar for GTPBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs138691 -- 38,719,305(+) CCCAG(C/G)CTGAT intron-variant
rs138692 -- 38,721,464(+) TGCCT(G/T)CCTTG intron-variant
rs138693 -- 38,722,217(+) ATGAT(C/T)AGTTA intron-variant
rs138694 -- 38,724,091(+) AAAGA(G/T)GCCCC intron-variant
rs138695 -- 38,724,233(+) TCTTG(C/T)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP1 Gene

Variant ID Type Subtype PubMed ID
nsv915067 CNV Loss 21882294
nsv915068 CNV Loss 21882294
dgv769n67 CNV Gain 20364138
esv991516 CNV Deletion 20482838

Relevant External Links for GTPBP1 Gene

HapMap Linkage Disequilibrium report
GTPBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP1 Gene

Disorders for GTPBP1 Gene

No disorders were found for GTPBP1 Gene.

No data available for UniProtKB/Swiss-Prot for GTPBP1 Gene

Publications for GTPBP1 Gene

  1. Identification of human and mouse GP-1, a putative member of a novel G-protein family. (PMID: 9070279) Senju S. … Nishimura Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. (PMID: 10833435) Kudo H. … Nishimura Y. (Biochem. Biophys. Res. Commun. 2000) 3 23
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GTPBP1 Gene

Sources for GTPBP1 Gene

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