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Aliases for GTF3C6 Gene

Aliases for GTF3C6 Gene

  • General Transcription Factor IIIC Subunit 6 2 3 5
  • General Transcription Factor IIIC, Polypeptide 6, Alpha 35kDa 2 3
  • Transcription Factor IIIC 35 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit 6 3 4
  • TFIIIC 35 KDa Subunit 3 4
  • TFIIIC35 3 4
  • C6orf51 3 4
  • Chromosome 6 Open Reading Frame 51 2
  • Transcription Factor IIIC 35kDa 3
  • BA397G5.3 3

External Ids for GTF3C6 Gene

Previous HGNC Symbols for GTF3C6 Gene

  • C6orf51

Previous GeneCards Identifiers for GTF3C6 Gene

  • GC06P111387
  • GC06P111280
  • GC06P108850

Summaries for GTF3C6 Gene

Entrez Gene Summary for GTF3C6 Gene

  • RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]

GeneCards Summary for GTF3C6 Gene

GTF3C6 (General Transcription Factor IIIC Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for GTF3C6 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C6 Gene

Genomics for GTF3C6 Gene

Regulatory Elements for GTF3C6 Gene

Enhancers for GTF3C6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF3C6 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF3C6 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF3C6 Gene

Chromosome:
6
Start:
110,958,560 bp from pter
End:
110,967,890 bp from pter
Size:
9,331 bases
Orientation:
Plus strand

Genomic View for GTF3C6 Gene

Genes around GTF3C6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C6 Gene

Proteins for GTF3C6 Gene

  • Protein details for GTF3C6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969F1-TF3C6_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 6
    Protein Accession:
    Q969F1
    Secondary Accessions:
    • Q5VXN2

    Protein attributes for GTF3C6 Gene

    Size:
    213 amino acids
    Molecular mass:
    24049 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with GTF3C4 and GTF3C5.

neXtProt entry for GTF3C6 Gene

Proteomics data for GTF3C6 Gene at MOPED

Post-translational modifications for GTF3C6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF3C6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF3C6 Gene

Domains & Families for GTF3C6 Gene

Gene Families for GTF3C6 Gene

Protein Domains for GTF3C6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTF3C6 Gene

Graphical View of Domain Structure for InterPro Entry

Q969F1

UniProtKB/Swiss-Prot:

TF3C6_HUMAN :
  • Belongs to the TFIIIC subunit 6 family.
Family:
  • Belongs to the TFIIIC subunit 6 family.
genes like me logo Genes that share domains with GTF3C6: view

Function for GTF3C6 Gene

Molecular function for GTF3C6 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
genes like me logo Genes that share phenotypes with GTF3C6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C6 Gene

Localization for GTF3C6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C6 Gene COMPARTMENTS Subcellular localization image for GTF3C6 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GTF3C6 Gene

Pathways & Interactions for GTF3C6 Gene

genes like me logo Genes that share pathways with GTF3C6: view

Gene Ontology (GO) - Biological Process for GTF3C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter IDA 17409385
genes like me logo Genes that share ontologies with GTF3C6: view

No data available for SIGNOR curated interactions for GTF3C6 Gene

Drugs & Compounds for GTF3C6 Gene

No Compound Related Data Available

Transcripts for GTF3C6 Gene

mRNA/cDNA for GTF3C6 Gene

Unigene Clusters for GTF3C6 Gene

General transcription factor IIIC, polypeptide 6, alpha 35kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C6 Gene

No ASD Table

Relevant External Links for GTF3C6 Gene

GeneLoc Exon Structure for
GTF3C6
ECgene alternative splicing isoforms for
GTF3C6

Expression for GTF3C6 Gene

mRNA expression in normal human tissues for GTF3C6 Gene

Protein differential expression in normal tissues from HIPED for GTF3C6 Gene

This gene is overexpressed in Fetal ovary (16.3), Testis (12.2), Fetal Brain (12.2), and Blymphocyte (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C6 Gene



SOURCE GeneReport for Unigene cluster for GTF3C6 Gene Hs.418520

genes like me logo Genes that share expression patterns with GTF3C6: view

Protein tissue co-expression partners for GTF3C6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C6 Gene

Orthologs for GTF3C6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF3C6 35
  • 89.21 (n)
  • 84.29 (a)
GTF3C6 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C6 35
  • 88.62 (n)
  • 82.21 (a)
GTF3C6 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c6 35
  • 80.4 (n)
  • 76.37 (a)
Gtf3c6 16
Gtf3c6 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF3C6 35
  • 99.84 (n)
  • 100 (a)
GTF3C6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c6 35
  • 80.37 (n)
  • 75 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF3C6 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves GTF3C6 35
  • 70.76 (n)
  • 70.76 (a)
GTF3C6 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C6 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4559 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.30586 35
zebrafish
(Danio rerio)
Actinopterygii zgc56388 35
gtf3c6 36
  • 39 (a)
OneToOne
Species with no ortholog for GTF3C6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C6 Gene

ENSEMBL:
Gene Tree for GTF3C6 (if available)
TreeFam:
Gene Tree for GTF3C6 (if available)

Paralogs for GTF3C6 Gene

Pseudogenes.org Pseudogenes for GTF3C6 Gene

genes like me logo Genes that share paralogs with GTF3C6: view

No data available for Paralogs for GTF3C6 Gene

Variants for GTF3C6 Gene

Sequence variations from dbSNP and Humsavar for GTF3C6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs5025088 -- 110,964,497(+) AGCCT(C/T)CCAAA intron-variant
rs5025089 -- 110,964,536(+) CACCC(A/G)GCCTT intron-variant
rs5025090 -- 110,964,576(+) CTGTT(A/G)CCTGG intron-variant
rs5879081 -- 110,963,704(+) CTGGC(-/T)TTTTT intron-variant
rs9487564 -- 110,964,835(+) ttttt(C/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF3C6 Gene

Variant ID Type Subtype PubMed ID
nsv886538 CNV Gain 21882294
nsv830773 CNV Loss 17160897
nsv509148 CNV Insertion 20534489

Variation tolerance for GTF3C6 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C6 Gene

HapMap Linkage Disequilibrium report
GTF3C6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C6 Gene

Disorders for GTF3C6 Gene

Relevant External Links for GTF3C6

Human Genome Epidemiology (HuGE) Navigator
GTF3C6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C6

No disorders were found for GTF3C6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C6 Gene

Publications for GTF3C6 Gene

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 2 3 4 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PMID: 16159877) McCracken S. … Blencowe B.J. (J. Biol. Chem. 2005) 3

Products for GTF3C6 Gene

Sources for GTF3C6 Gene

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