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Aliases for GTF3C6 Gene

Aliases for GTF3C6 Gene

  • General Transcription Factor IIIC Subunit 6 2 3 5
  • General Transcription Factor IIIC, Polypeptide 6, Alpha 35kDa 2 3
  • Transcription Factor IIIC 35 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit 6 3 4
  • TFIIIC 35 KDa Subunit 3 4
  • TFIIIC35 3 4
  • C6orf51 3 4
  • General Transcription Factor 3C Polypeptide 6 3
  • Chromosome 6 Open Reading Frame 51 2
  • Transcription Factor IIIC 35kDa 3
  • BA397G5.3 3

External Ids for GTF3C6 Gene

Previous HGNC Symbols for GTF3C6 Gene

  • C6orf51

Previous GeneCards Identifiers for GTF3C6 Gene

  • GC06P111387
  • GC06P111280
  • GC06P108850

Summaries for GTF3C6 Gene

Entrez Gene Summary for GTF3C6 Gene

  • RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]

GeneCards Summary for GTF3C6 Gene

GTF3C6 (General Transcription Factor IIIC Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for GTF3C6 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C6 Gene

Genomics for GTF3C6 Gene

Regulatory Elements for GTF3C6 Gene

Enhancers for GTF3C6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G110873 1.8 FANTOM5 ENCODE dbSUPER 11.5 -82.0 -82005 6.6 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RPF2 CDK19 FCF1P5 GTF3C6 RNU6-957P MFSD4B AMD1 SLC16A10 ENSG00000271607 GC06P110895
GH06G110681 1.5 Ensembl ENCODE dbSUPER 11.3 -276.2 -276237 1.4 PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF143 ZNF207 AMD1 CDK19 GTF3C6 RNU6-957P RPF2 CNN2P9 RPS20P18 LOC100129155
GH06G110536 1.5 Ensembl ENCODE dbSUPER 11 -421.0 -420965 2.1 PKNOX1 ATF1 MLX SIN3A GATA2 FOS JUNB ZNF518A MIER3 SMARCA4 ENSG00000272356 GTF3C6 SLC22A16 RPF2 RNU6-957P ENSG00000220506 LOC105377940 GC06P110478
GH06G110564 1.5 Ensembl ENCODE dbSUPER 10 -391.6 -391560 4.5 MLX ARID4B DMAP1 ZNF48 YY1 SP5 NFYC JUNB MIER2 PPARG RNU6-957P GTF3C6 RPF2 ENSG00000271789 RPS19P5 GC06M110563
GH06G110617 1.3 FANTOM5 ENCODE dbSUPER 10.5 -341.2 -341244 0.4 TBL1XR1 EBF1 RELA POLR2A EED ETV6 RELB IKZF2 CREM MTA2 GTF3C6 SLC16A10 AMD1 LOC100420531 LOC100129155
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTF3C6 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201104 440 1601 HDGF HNRNPUL1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1

Genomic Location for GTF3C6 Gene

Chromosome:
6
Start:
110,958,560 bp from pter
End:
110,967,890 bp from pter
Size:
9,331 bases
Orientation:
Plus strand

Genomic View for GTF3C6 Gene

Genes around GTF3C6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C6 Gene

Proteins for GTF3C6 Gene

  • Protein details for GTF3C6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969F1-TF3C6_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 6
    Protein Accession:
    Q969F1
    Secondary Accessions:
    • Q5VXN2

    Protein attributes for GTF3C6 Gene

    Size:
    213 amino acids
    Molecular mass:
    24049 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with GTF3C4 and GTF3C5.

neXtProt entry for GTF3C6 Gene

Post-translational modifications for GTF3C6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF3C6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF3C6 Gene

Domains & Families for GTF3C6 Gene

Gene Families for GTF3C6 Gene

Protein Domains for GTF3C6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTF3C6 Gene

Graphical View of Domain Structure for InterPro Entry

Q969F1

UniProtKB/Swiss-Prot:

TF3C6_HUMAN :
  • Belongs to the TFIIIC subunit 6 family.
Family:
  • Belongs to the TFIIIC subunit 6 family.
genes like me logo Genes that share domains with GTF3C6: view

Function for GTF3C6 Gene

Molecular function for GTF3C6 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Gene Ontology (GO) - Molecular Function for GTF3C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IDA,IEA 17409385
GO:0005515 protein binding IPI 17409385
genes like me logo Genes that share ontologies with GTF3C6: view
genes like me logo Genes that share phenotypes with GTF3C6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C6 Gene

Localization for GTF3C6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C6 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GTF3C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with GTF3C6: view

Pathways & Interactions for GTF3C6 Gene

genes like me logo Genes that share pathways with GTF3C6: view

Gene Ontology (GO) - Biological Process for GTF3C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA 17409385
GO:0006383 transcription from RNA polymerase III promoter IDA 17409385
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter IC 17409385
GO:0042797 tRNA transcription from RNA polymerase III promoter IC 17409385
genes like me logo Genes that share ontologies with GTF3C6: view

No data available for SIGNOR curated interactions for GTF3C6 Gene

Drugs & Compounds for GTF3C6 Gene

No Compound Related Data Available

Transcripts for GTF3C6 Gene

mRNA/cDNA for GTF3C6 Gene

Unigene Clusters for GTF3C6 Gene

General transcription factor IIIC, polypeptide 6, alpha 35kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C6 Gene

No ASD Table

Relevant External Links for GTF3C6 Gene

GeneLoc Exon Structure for
GTF3C6
ECgene alternative splicing isoforms for
GTF3C6

Expression for GTF3C6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF3C6 Gene

Protein differential expression in normal tissues from HIPED for GTF3C6 Gene

This gene is overexpressed in Fetal ovary (16.3), Testis (12.2), Fetal Brain (12.2), and Blymphocyte (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C6 Gene



Protein tissue co-expression partners for GTF3C6 Gene

NURSA nuclear receptor signaling pathways regulating expression of GTF3C6 Gene:

GTF3C6

SOURCE GeneReport for Unigene cluster for GTF3C6 Gene:

Hs.418520

Evidence on tissue expression from TISSUES for GTF3C6 Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with GTF3C6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C6 Gene

Orthologs for GTF3C6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C6 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia GTF3C6 34 35
  • 89.21 (n)
dog
(Canis familiaris)
Mammalia GTF3C6 34 35
  • 88.62 (n)
mouse
(Mus musculus)
Mammalia Gtf3c6 34 16 35
  • 80.4 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c6 34
  • 80.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GTF3C6 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C6 34 35
  • 70.76 (n)
lizard
(Anolis carolinensis)
Reptilia GTF3C6 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4559 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.30586 34
zebrafish
(Danio rerio)
Actinopterygii gtf3c6 35
  • 39 (a)
OneToOne
zgc56388 34
Species where no ortholog for GTF3C6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C6 Gene

ENSEMBL:
Gene Tree for GTF3C6 (if available)
TreeFam:
Gene Tree for GTF3C6 (if available)

Paralogs for GTF3C6 Gene

Pseudogenes.org Pseudogenes for GTF3C6 Gene

genes like me logo Genes that share paralogs with GTF3C6: view

No data available for Paralogs for GTF3C6 Gene

Variants for GTF3C6 Gene

Sequence variations from dbSNP and Humsavar for GTF3C6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000077608 -- 110,961,830(+) TCTCA(C/T)TCATA intron-variant
rs1000285598 -- 110,967,290(+) GGTAA(C/T)GTAGT intron-variant
rs1000428351 -- 110,962,623(+) TTTTT(C/G)AGACA intron-variant
rs1000635946 -- 110,967,723(+) TTCTG(G/T)TCCTC reference, missense
rs1000911119 -- 110,957,307(+) CAGAG(A/G)TAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GTF3C6 Gene

Variant ID Type Subtype PubMed ID
nsv1016001 CNV gain 25217958
nsv1032572 CNV gain 25217958
nsv509148 CNV insertion 20534489
nsv830773 CNV loss 17160897

Variation tolerance for GTF3C6 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C6 Gene

Disorders for GTF3C6 Gene

Relevant External Links for GTF3C6

Human Genome Epidemiology (HuGE) Navigator
GTF3C6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C6

No disorders were found for GTF3C6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C6 Gene

Publications for GTF3C6 Gene

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for GTF3C6 Gene

Sources for GTF3C6 Gene

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