Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GTF3C5 Gene

protein-coding   GIFtS: 56
GCID: GC09P135906

General Transcription Factor IIIC, Polypeptide 5, 63kDa

(Previous names: general transcription factor IIIC, polypeptide 5 (63kD))
  Search for GTF3C5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
General Transcription Factor IIIC, Polypeptide 5, 63kDa1 2     General Transcription Factor IIIC, Polypeptide 5 (63kD)1
Transcription Factor IIIC 63 KDa Subunit2 3     Transcription Factor IIIC1
Transcription Factor IIIC Subunit Epsilon2 3     TFIIICepsilon2
TF3C-epsilon2 3     TFiiiC2-632
TFIIIC632 3     General Transcription Factor 3C Polypeptide 52
TFIIIC 63 KDa Subunit2 3     Transcription Factor IIIC, 63 KD2
63 KD1     

External Ids:    HGNC: 46681   Entrez Gene: 93282   Ensembl: ENSG000001483087   OMIM: 6048905   UniProtKB: Q9Y5Q83   

Export aliases for GTF3C5 gene to outside databases

Previous GC identifers: GC09P126930 GC09P127462 GC09P129259 GC09P131182 GC09P132935 GC09P134895 GC09P105399


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for GTF3C5 Gene:
GTF3C5 (general transcription factor IIIC, polypeptide 5, 63kDa) is a protein-coding gene.

UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8
Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the
DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

Gene Wiki entry for GTF3C5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF3C5 gene promoter:
         TBP   NF-1   AP-2gamma   Tal-1beta   E47   AP-2beta   Cart-1   GCNF-2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF3C5 promoter sequence
   Search Chromatin IP Primers for GTF3C5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF3C5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.13

GTF3C5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3C5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P135906:  view genomic region     (about GC identifiers)

Start:
135,906,062 bp from pter      End:
135,933,890 bp from pter
Size:
27,829 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8 (See protein sequence)
Recommended Name: General transcription factor 3C polypeptide 5  
Size: 519 amino acids; 59571 Da
Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5
and GTF3C6. Interacts with BRF1, GTF3C6 and TBP
Secondary accessions: A6NI44 A6NJB9 Q5T7U2 Q5T7U3 Q8N2U7 Q8N857 Q96GD9 Q9H4P2
Alternative splicing: 3 isoforms:  Q9Y5Q8-1   Q9Y5Q8-2   Q9Y5Q8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GTF3C5: NX_Q9Y5Q8

Explore proteomics data for GTF3C5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38, Lys256, Lys367
  • Modification sites at PhosphoSitePlus

  • See GTF3C5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116295.1  NP_001273638.1  NP_036219.2  

    ENSEMBL proteins: 
     ENSP00000361169   ENSP00000389498   ENSP00000361180   ENSP00000339530   ENSP00000393207  
     ENSP00000397961   ENSP00000361171   ENSP00000361167  
    Reactome Protein details: Q9Y5Q8

    GTF3C5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GTF3C5
    OriGene Protein Over-expression Lysate for GTF3C5
    OriGene MassSpec for GTF3C5
    OriGene Custom Protein Services for GTF3C5
    GenScript Custom Purified and Recombinant Proteins Services for GTF3C5
    Novus Biologicals GTF3C5 Proteins
    Novus Biologicals GTF3C5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GTF3C5

     
    Search eBioscience for Proteins for GTF3C5 

    GTF3C5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GTF3C5
    Novus Biologicals GTF3C5 Antibodies
    Abcam antibodies for GTF3C5 (Q5T7U2, Q9Y5Q8, Q5T7U3)
    Cloud-Clone Corp. Antibodies for GTF3C5
    Search ThermoFisher Antibodies for GTF3C5
    LSBio Antibodies in human, mouse, rat for GTF3C5

    GTF3C5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GTF3C5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTF3C5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GTF3C5
    Cloud-Clone Corp. CLIAs for GTF3C5
    Search eBioscience for ELISAs for GTF3C5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GTF: General transcription factors

    1 InterPro protein domain:
     IPR019136 TF_IIIC_su-5

    Graphical View of Domain Structure for InterPro Entry Q9Y5Q8

    ProtoNet protein and cluster: Q9Y5Q8

    UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8
    Similarity: Belongs to the TFIIIC subunit 5 family


    Find genes that share domains with GTF3C5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF3C5_HUMAN, Q9Y5Q8
    Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the
    DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677contributes to DNA binding IC17409385
    GO:0005515protein binding IPI17409385
         
    Find genes that share ontologies with GTF3C5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GTF3C5:
     Metaphase cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gtf3c5):
     mortality/aging 

    Find genes that share phenotypes with GTF3C5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF3C5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTF3C5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GTF3C5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GTF3C5

    miRNA
    Products:
        
    miRTarBase miRNAs that target GTF3C5:
    hsa-let-7a-5p (MIRT052437), hsa-mir-222-3p (MIRT046697), hsa-mir-7-5p (MIRT025954), hsa-mir-877-3p (MIRT037096), hsa-mir-652-3p (MIRT039525), hsa-mir-124-3p (MIRT023140)

    Block miRNA regulation of human, mouse, rat GTF3C5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GTF3C5
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GTF3C5
    Predesigned siRNA for gene silencing in human, mouse, rat GTF3C5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GTF3C5

    Clone
    Products:
         
    OriGene clones in human, mouse for GTF3C5 (see all 12)
    OriGene ORF clones in mouse, rat for GTF3C5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C5 (NM_012087)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF3C5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GTF3C5
    Browse ESI BIO Cell Lines and PureStem Progenitors for GTF3C5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TF3C5_HUMAN, Q9Y5Q8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000127transcription factor TFIIIC complex IDA17409385
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with GTF3C5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GTF3C5 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 1 Promoter0.77
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
    RNA Polymerase III Transcription0.88
    2Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex0.00
    Transcription of tRNA
    3RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    4Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with GTF3C5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF3C5
        Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex

    3 Reactome Pathways for GTF3C5
        RNA Polymerase III Transcription Initiation From Type 1 Promoter
    RNA Polymerase III Transcription Initiation From Type 2 Promoter
    RNA Polymerase III Abortive And Retractive Initiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF3C5
    Interactions:

        GeneGlobe Interaction Network for GTF3C5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF3C5 (Q9Y5Q82, 3 ENSP000003611804) via UniProtKB, MINT, STRING, and/or I2D (see all 606)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF3C2Q8WUA42, 3, ENSP000002647204MINT-7947479 I2D: score=1 STRING: ENSP00000264720
    GTF3C4Q9UKN83, ENSP000003612194I2D: score=2 STRING: ENSP00000361219
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    GTF3C3Q9Y5Q93, ENSP000002639564I2D: score=1 STRING: ENSP00000263956
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IC17409385
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--
    GO:0035914skeletal muscle cell differentiation IEA--
    GO:00427915S class rRNA transcription from RNA polymerase III type 1 promoter IC17409385

    Find genes that share ontologies with GTF3C5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF3C5 (TF3C5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GTF3C5 gene (3 alternative transcripts): 
    NM_001122823.1  NM_001286709.1  NM_012087.3  

    Unigene Cluster for GTF3C5:

    General transcription factor IIIC, polypeptide 5, 63kDa
    Hs.495417  [show with all ESTs]
    Unigene Representative Sequence: NM_001122823
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372097(uc004ccj.4 uc004cci.4) ENST00000440319 ENST00000372108
    ENST00000342018 ENST00000439697 ENST00000485692 ENST00000461871 ENST00000435745
    ENST00000489842 ENST00000372099 ENST00000372095(uc010mzz.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GTF3C5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GTF3C5
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GTF3C5
    Predesigned siRNA for gene silencing in human, mouse, rat GTF3C5
    Clone
    Products:
         
    OriGene clones in human, mouse for GTF3C5 (see all 12)
    OriGene ORF clones in mouse, rat for GTF3C5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C5 (NM_012087)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF3C5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GTF3C5
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF3C5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF3C5
      QuantiTect SYBR Green Assays in human, mouse, rat GTF3C5
      QuantiFast Probe-based Assays in human, mouse, rat GTF3C5

    Additional mRNA sequence: 

    AF133124.1 AJ420443.1 AK000194.1 AK024510.1 AK055092.1 AK097295.1 AK225761.1 AK293980.1 
    AK311481.1 AY007123.1 BC006409.1 BC009741.2 BC011355.1 BC017337.2 BC030157.2 

    23 DOTS entries:

    DT.91753456  DT.91753455  DT.100773131  DT.100667094  DT.97855036  DT.100764694  DT.102823202  DT.100667097 
    DT.121160492  DT.40288357  DT.91705626  DT.95147878  DT.100862869  DT.102823203  DT.121160486  DT.121160502 
    DT.121160528  DT.121160573  DT.91929372  DT.91988142  DT.95147884  DT.99997137  DT.95263106 

    Selected AceView cDNA sequences (see all 42):

    BC009741 BI059777 CR614381 BC011355 BC030157 CK821755 CK902158 CR604474 
    AY007123 BC017337 CR610972 AK055092 AJ420443 AK000194 BX434299 AK024510 
    AK097295 CK902159 Z28491 AA837430 BF765602 BX457189 AI908756 BC006409 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C5 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a ·
    SP1:                                                                                            -     -                                                         
    SP2:                                                        -     -     -     -     -     -     -     -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                        -     -     -                       -     -                                                         
    SP5:                                                                                -           -     -                                                         

    ExUns: 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
    SP1:                          -     -           -               
    SP2:                                                            
    SP3:                          -     -                           
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for GTF3C5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GTF3C5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCACGTG
    GTF3C5 Expression
    About this image

    GTF3C5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF3C5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495417
        Custom PCR Arrays for GTF3C5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GTF3C5
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF3C5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF3C5
    QuantiTect SYBR Green Assays in human, mouse, rat GTF3C5
    QuantiFast Probe-based Assays in human, mouse, rat GTF3C5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GTF3C5 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf3c51 , 5 general transcription factor IIIC, polypeptide 51, 5 83.69(n)1
    85.38(a)1
      2 (19.38 cM)5
    702391  NM_148928.21  NP_683730.11 
     285663115 
    chicken
    (Gallus gallus)
    Aves GTF3C56
    Gallus gallus general transcription factor IIIC, p...
    68(a)
    1 ↔ 1
    17(6780509-6787429)
    lizard
    (Anolis carolinensis)
    Reptilia GTF3C56
    general transcription factor IIIC, polypeptide 5, ...
    77(a)
    1 ↔ 1
    AAWZ02037281(917-3083)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41792 Xenopus laevis transcribed sequence with weak similarity more 79.75(n)    BX849560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.171622 Danio rerio, clone IMAGE2600619, mRNA 74.93(n)    BC044365.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)37Cd1 lethal (2) 37Cd 44.53(n)
    31.78(a)
      35193  NM_136103.3  NP_609947.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T02C12.31 CELE_T02C12.3 40.78(n)
    31.65(a)
      175520  NM_065407.3  NP_497808.1 


    ENSEMBL Gene Tree for GTF3C5 (if available)
    TreeFam Gene Tree for GTF3C5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GTF3C5 (see all 722)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163743141,2
    F--135904063(+) GAAATC/TACAGG 2 -- us2k11Minor allele frequency- T:0.05WA 118
    rs46315821,2
    F,A--135904074(+) CTGGGC/AACGGT 2 -- us2k13Minor allele frequency- A:0.08NA 124
    rs1135299531,2
    C,F--135904239(+) CTACCC/TGGGAG 2 -- us2k13Minor allele frequency- T:0.04NA EA 242
    rs1456630611,2
    --135904258(+) AGGAGA/CATCGC 2 -- us2k10--------
    rs8041651,2
    C,F,A--135904266(+) cgcttA/Gtacca 2 -- us2k19Minor allele frequency- G:0.32NA WA CSA EA 371
    rs1131224341,2
    C,F--135904282(+) TCGGAG/AGTTGC 2 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs8041661,2
    C,F,A,H--135904340(+) ggctcT/Cgtctc 2 -- us2k18Minor allele frequency- C:0.28NA WA CSA EA 253
    rs1891716381,2
    --135904508(+) TTCGGC/GGCTGC 2 -- us2k10--------
    rs1808703531,2
    --135904509(+) TCGGGA/GCTGCA 2 -- us2k10--------
    rs29885711,2
    C,F,H--135904566(+) AGATCG/ATGTCT 2 -- us2k117Minor allele frequency- A:0.19NS EA NA WA 2336

    HapMap Linkage Disequilibrium report for GTF3C5 (135906062 - 135933890 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GTF3C5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv6746CNV Insertion18451855
    nsv508564CNV Loss20534489
    nsv520759CNV Loss19592680
    nsv466606CNV Loss19166990
    nsv894028CNV Loss21882294
    nsv819112CNV Gain19587683
    nsv831744CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF3C5
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF3C5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604890    OMIM disorders: --


    Find genes that share disorders with GTF3C5           About GenesLikeMe

    Genetic Association Database (GAD): GTF3C5
    Human Genome Epidemiology (HuGE) Navigator: GTF3C5 (3 documents)

    Export disorders for GTF3C5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GTF3C5 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with GTF3C5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PubMed id 10373544)1, 2, 3 Hsieh Y.-J.... Roeder R.G. (Mol. Cell. Biol. 1999)
    2. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PubMed id 17409385)1, 2, 9 Dumay-Odelot H.... Teichmann M. (J. Biol. Chem. 2007)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9328 HGNC: 4668 AceView: GTF3C5 Ensembl:ENSG00000148308 euGenes: HUgn9328
    ECgene: GTF3C5 H-InvDB: GTF3C5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GTF3C5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GTF3C5 gene:
    Search GeneIP for patents involving GTF3C5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GTF3C5  
     OriGene qPCR primer pairs and template standards for GTF3C5   OriGene Protein Over-expression Lysate for GTF3C5  
     OriGene MassSpec something-or-other for GTF3C5   OriGene clones in human, mouse for GTF3C5  
     OriGene qSTAR qPCR primer pairs in human, mouse for GTF3C5   OriGene Purified Protein for GTF3C5  
     OriGene ORF clones in mouse, rat for GTF3C5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GTF3C5   OriGene Custom Protein Services for GTF3C5  

     
     
     Block miRNA regulation of human, mouse, rat GTF3C5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GTF3C5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF3C5 Predesigned siRNA for gene silencing in human, mouse, rat GTF3C5
     QuantiFast Probe-based Assays in human, mouse, rat GTF3C5 QuantiTect SYBR Green Assays in human, mouse, rat GTF3C5
     Custom PCR Arrays for GTF3C5 Search Chromatin IP Primers for GTF3C5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF3C5  GeneGlobe Interaction Network for GTF3C5
     Regulatory tfbs in GTF3C5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GTF3C5 GenScript cDNA clones with any tag delivered in your preferred vector for GTF3C5
     GenScript Custom Assay Services for GTF3C5 GenScript Custom overexpressing Cell Line Services for GTF3C5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GTF3C5 (TF3C5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GTF3C5 antibodies
     GTF3C5 proteins
     GTF3C5 lysates
     Antibodies for GTF3C5
     See all of Abcam's Antibodies, Kits and Proteins for GTF3C5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GTF3C5
     Antibodies for GTF3C5
     ELISAs for GTF3C5
     CLIAs for GTF3C5



     Browse ESI BIO Cell Lines and PureStem Progenitors for GTF3C5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C5
     SwitchGear 3'UTR luciferase reporter plasmids for GTF3C5
     SwitchGear Promoter luciferase reporter plasmids for GTF3C5
     Search ThermoFisher Antibodies for GTF3C5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF3C5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTF3C5
     LSBio Antibodies in human, mouse, rat for GTF3C5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GTF3C5
      Search eBioscience for proteins for GTF3C5
      Search eBioscience for elisas for GTF3C5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GTF3C5 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4