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Aliases for GTF3C5 Gene

Aliases for GTF3C5 Gene

  • General Transcription Factor IIIC, Polypeptide 5, 63kDa 2 3
  • Transcription Factor IIIC Subunit Epsilon 3 4
  • Transcription Factor IIIC 63 KDa Subunit 3 4
  • TFIIIC 63 KDa Subunit 3 4
  • TF3C-Epsilon 3 4
  • TFIIIC63 3 4
  • General Transcription Factor IIIC, Polypeptide 5 (63kD) 2
  • General Transcription Factor 3C Polypeptide 5 3
  • Transcription Factor IIIC, 63 KD 3
  • Transcription Factor IIIC 2
  • TFIIICepsilon 3
  • TFiiiC2-63 3
  • 63 KD 2

External Ids for GTF3C5 Gene

Summaries for GTF3C5 Gene

GeneCards Summary for GTF3C5 Gene

GTF3C5 (General Transcription Factor IIIC, Polypeptide 5, 63kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for GTF3C5 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

Gene Wiki entry for GTF3C5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C5 Gene

Genomics for GTF3C5 Gene

Genomic Location for GTF3C5 Gene

Start:
133,030,675 bp from pter
End:
133,058,503 bp from pter
Size:
27,829 bases
Orientation:
Plus strand

Genomic View for GTF3C5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF3C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C5 Gene

Regulatory Elements for GTF3C5 Gene

Proteins for GTF3C5 Gene

  • Protein details for GTF3C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q8-TF3C5_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 5
    Protein Accession:
    Q9Y5Q8
    Secondary Accessions:
    • A6NI44
    • A6NJB9
    • Q5T7U2
    • Q5T7U3
    • Q8N2U7
    • Q8N857
    • Q96GD9
    • Q9H4P2

    Protein attributes for GTF3C5 Gene

    Size:
    519 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.

    Alternative splice isoforms for GTF3C5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C5 Gene

Proteomics data for GTF3C5 Gene at MOPED

Post-translational modifications for GTF3C5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys38, Lys256, and Lys367

Other Protein References for GTF3C5 Gene

No data available for DME Specific Peptides for GTF3C5 Gene

Domains for GTF3C5 Gene

Gene Families for GTF3C5 Gene

HGNC:
  • GTF :General transcription factors

Protein Domains for GTF3C5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TF3C5_HUMAN
Family:
  • Belongs to the TFIIIC subunit 5 family.:
    • Q9Y5Q8
genes like me logo Genes that share domains with GTF3C5: view

Function for GTF3C5 Gene

Molecular function for GTF3C5 Gene

UniProtKB/Swiss-Prot Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

Gene Ontology (GO) - Molecular Function for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IC 17409385
GO:0005515 protein binding IPI 17409385
genes like me logo Genes that share ontologies with GTF3C5: view

Phenotypes for GTF3C5 Gene

MGI mutant phenotypes for GTF3C5:
inferred from 1 alleles
GenomeRNAi human phenotypes for GTF3C5:
genes like me logo Genes that share phenotypes with GTF3C5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GTF3C5 Gene

Localization for GTF3C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C5 Gene COMPARTMENTS Subcellular localization image for GTF3C5 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C5: view

Pathways for GTF3C5 Gene

genes like me logo Genes that share pathways with GTF3C5: view

Gene Ontology (GO) - Biological Process for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter IC 17409385
genes like me logo Genes that share ontologies with GTF3C5: view

Transcripts for GTF3C5 Gene

Unigene Clusters for GTF3C5 Gene

General transcription factor IIIC, polypeptide 5, 63kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - -
SP2: - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - -
SP11:
SP12: - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - - - - - - -
SP15: - - - - - - - - -
SP16: - - -

ExUns: 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for GTF3C5 Gene

GeneLoc Exon Structure for
GTF3C5
ECgene alternative splicing isoforms for
GTF3C5

Expression for GTF3C5 Gene

mRNA expression in normal human tissues for GTF3C5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C5 Gene

SOURCE GeneReport for Unigene cluster for GTF3C5 Gene Hs.495417

genes like me logo Genes that share expressions with GTF3C5: view

Orthologs for GTF3C5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3C5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C5 36
  • 98.87 (n)
  • 99.4 (a)
GTF3C5 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTF3C5 36
  • 85.32 (n)
  • 84.93 (a)
GTF3C5 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C5 36
  • 86.88 (n)
  • 88.27 (a)
GTF3C5 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c5 36
  • 83.69 (n)
  • 85.38 (a)
Gtf3c5 16
Gtf3c5 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF3C5 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C5 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c5 36
  • 83.5 (n)
  • 84.08 (a)
chicken
(Gallus gallus)
Aves GTF3C5 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C5 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4179 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c5 36
  • 70.31 (n)
  • 68.42 (a)
Str.13723 36
zebrafish
(Danio rerio)
Actinopterygii Dr.17162 36
gtf3c5 36
  • 59.69 (n)
  • 55.73 (a)
gtf3c5 37
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009321 36
  • 45.32 (n)
  • 33.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cd 36
  • 44.53 (n)
  • 31.78 (a)
l(2)37Cd 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T02C12.3 36
  • 40.78 (n)
  • 31.65 (a)
tftc-5 37
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToOne
Species with no ortholog for GTF3C5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF3C5 Gene

ENSEMBL:
Gene Tree for GTF3C5 (if available)
TreeFam:
Gene Tree for GTF3C5 (if available)

Paralogs for GTF3C5 Gene

No data available for Paralogs for GTF3C5 Gene

Variants for GTF3C5 Gene

Sequence variations from dbSNP and Humsavar for GTF3C5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs600252 -- 133,040,838(+) ccagt(A/T)taata intron-variant
rs603098 -- 133,041,643(+) cccgc(A/G)ttttg intron-variant
rs630288 -- 133,043,094(+) AAGAG(G/T)ACTAG intron-variant
rs636219 -- 133,029,759(+) GATCA(C/T)TTGAG upstream-variant-2KB
rs636221 -- 133,029,762(+) CATTT(C/G)AGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GTF3C5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv831744 CNV Gain+Loss 17160897
nsv508564 CNV Loss 20534489
nsv520759 CNV Loss 19592680
nsv466606 CNV Loss 19166990
nsv894028 CNV Loss 21882294
nsv6746 CNV Insertion 18451855
nsv819112 CNV Gain 19587683

Relevant External Links for GTF3C5 Gene

HapMap Linkage Disequilibrium report
GTF3C5

Disorders for GTF3C5 Gene

Relevant External Links for GTF3C5

Genetic Association Database (GAD)
GTF3C5
Human Genome Epidemiology (HuGE) Navigator
GTF3C5
genes like me logo Genes that share disorders with GTF3C5: view

No data available for UniProtKB/Swiss-Prot for GTF3C5 Gene

Publications for GTF3C5 Gene

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 3 4 23
  2. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for GTF3C5 Gene

Sources for GTF3C5 Gene

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