Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GTF3C5 Gene

protein-coding   GIFtS: 53
GCID: GC09P135906

general transcription factor IIIC, polypeptide 5, 63kDa

(Previous names: general transcription factor IIIC, polypeptide 5 (63kD)...)
 Explore 2 diseases affiliated with
GTF3C5 via our new
 Human Malady Compendium 
Biological research products
for GTF3C5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
General Transcription Factor IIIC, Polypeptide 5, 63kDa1 2     TF3C-Epsilon1
TFIIIC631 2 3     TFIIIC 63 KDa Subunit2 3
TFIIICepsilon1 2     General Transcription Factor IIIC, Polypeptide 5 (63kD)1
TFiiiC2-631 2     General Transcription Factor 3C Polypeptide 52
Transcription Factor IIIC 63 KDa Subunit2 3     Transcription Factor IIIC, 63 KD2
Transcription Factor IIIC Subunit Epsilon2 3     

External Ids:    HGNC: 46681   Entrez Gene: 93282   Ensembl: ENSG000001483087   OMIM: 6048905   UniProtKB: Q9Y5Q83   

Export aliases for GTF3C5 gene to outside databases

Previous GC identifers: GC09P126930 GC09P127462 GC09P129259 GC09P131182 GC09P132935 GC09P134895 GC09P105399


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8
Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the
DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

Gene Wiki entry for GTF3C5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTF3C5 gene promoter:
         TBP   NF-1   AP-2gamma   Tal-1beta   E47   AP-2beta   Cart-1   GCNF-2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF3C5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GTF3C5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF3C5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.13

GTF3C5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3C5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P135906:  view genomic region     (about GC identifiers)

Start:
135,906,062 bp from pter      End:
135,933,890 bp from pter
Size:
27,829 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8 (See protein sequence)
Recommended Name: General transcription factor 3C polypeptide 5  
Size: 519 amino acids; 59571 Da
Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and
GTF3C6. Interacts with BRF1, GTF3C6 and TBP
Subcellular location: Nucleus
Secondary accessions: A6NI44 A6NJB9 Q5T7U2 Q5T7U3 Q8N2U7 Q8N857 Q96GD9 Q9H4P2
Alternative splicing: 3 isoforms:  Q9Y5Q8-1   Q9Y5Q8-2   Q9Y5Q8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GTF3C5: NX_Q9Y5Q8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5Q8

  • GTF3C5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116295.1  NP_036219.2  

    ENSEMBL proteins: 
     ENSP00000361169   ENSP00000389498   ENSP00000361180   ENSP00000339530   ENSP00000393207  
     ENSP00000387697   ENSP00000397961   ENSP00000361171   ENSP00000361167  
    Reactome Protein details: Q9Y5Q8
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: GTF3C5
    OriGene Protein Over-expression Lysate: GTF3C5
    OriGene Custom Protein Services for GTF3C5 
    GenScript Custom Purified and Recombinant Proteins Services for GTF3C5
    Novus Biologicals GTF3C5 Proteins
    Novus Biologicals GTF3C5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GTF3C5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000127transcription factor TFIIIC complex IDA17409385
    GO:0005654nucleoplasm TAS--


    GTF3C5 for ontologies           About GeneDecksing



    GTF3C5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GTF3C5 
    GenScript Custom Superior Antibodies Services for GTF3C5
    Novus Biologicals GTF3C5 Antibodies
    Search for Antibodies for GTF3C5 at Abcam  
    Uscn Antibodies for GTF3C5
    Search ThermoFisher Antibodies for GTF3C5

    Assay Products for GTF3C5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTF3C5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GTF3C5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GTF3C5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019136 TF_IIIC_su-5

    Graphical View of Domain Structure for InterPro Entry Q9Y5Q8

    ProtoNet protein and cluster: Q9Y5Q8

    UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8
    Similarity: Belongs to the TFIIIC subunit 5 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TF3C5_HUMAN, Q9Y5Q8
    Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the
    DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): GTF3C5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GTF3C5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GTF3C5
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GTF3C5 (see all 7)
    OriGene shRNA RFP: GTF3C5
    OriGene siRNA: GTF3C5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GTF3C5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GTF3C5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C5 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C5 (NM_012087)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF3C5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GTF3C5
    Search LifeMap BioReagents cell lines for GTF3C5

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677contributes to DNA binding IC17409385
    GO:0005515protein binding IPI17409385


    GTF3C5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GTF3C5:
     Metaphase cells 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gtf3c5):
     mortality/aging 

    GTF3C5 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation1.00
    RNA Polymerase III Transcription Initiation From Type 1 Promoter0.77
    RNA Polymerase III Abortive And Retractive Initiation1.00
    RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
    RNA Polymerase III Transcription1.00
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    2Assembly of RNA Polymerase-III Initiation Complex
    Assembly of RNA Polymerase-III Initiation Complex1.00
    Transcription of tRNA0.83
    3Transcription
    Transcription1.00
    4Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF3C5
        Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex

    5/8        Reactome Pathways for GTF3C5 (see all 8)
        RNA Polymerase III Transcription Initiation
    Transcription
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
    RNA Polymerase III Abortive And Retractive Initiation
    RNA Polymerase III Transcription Initiation From Type 1 Promoter



    GTF3C5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF3C5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/563 Interacting proteins for GTF3C5 (Q9Y5Q82, 3 ENSP000003611804) via UniProtKB, MINT, STRING, and/or I2D (see all 563)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF3C2Q8WUA42, 3, ENSP000002647204MINT-7947479 I2D: score=1 STRING: ENSP00000264720
    GTF3C4Q9UKN83, ENSP000003612194I2D: score=2 STRING: ENSP00000361219
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    GTF3C3Q9Y5Q93, ENSP000002639564I2D: score=1 STRING: ENSP00000263956
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IC17409385
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--
    GO:00427915S class rRNA transcription from RNA polymerase III type 1 promoter IC17409385
    GO:0042797tRNA transcription from RNA polymerase III promoter IC17409385


    GTF3C5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTF3C5
    Search CenterWatch for drugs/clinical trials and news about GTF3C5 / TF3C5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GTF3C5 gene (2 alternative transcripts): 
    NM_001122823.1  NM_012087.3  

    Unigene Cluster for GTF3C5:

    General transcription factor IIIC, polypeptide 5, 63kDa
    Hs.495417  [show with all ESTs]
    Unigene Representative Sequence: NM_001122823
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372097(uc004ccj.4 uc004cci.4) ENST00000440319 ENST00000372108
    ENST00000342018 ENST00000439697 ENST00000485692 ENST00000460815 ENST00000434175
    ENST00000461871 ENST00000435745 ENST00000489842 ENST00000372099 ENST00000372095(uc010mzz.2)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): GTF3C5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GTF3C5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GTF3C5
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GTF3C5 (see all 7)
    OriGene shRNA RFP: GTF3C5
    OriGene siRNA: GTF3C5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GTF3C5
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C5 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C5 (NM_012087)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF3C5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C5 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTF3C5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GTF3C5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF3C5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF3C5

    Additional cDNA sequence: 

    AF133124.1 AJ420443.1 AK000194.1 AK024510.1 AK055092.1 AK097295.1 AK225761.1 AK293980.1 
    AK311481.1 AY007123.1 BC006409.1 BC009741.2 BC011355.1 BC017337.2 BC030157.2 

    23 DOTS entries:

    DT.91753456  DT.91753455  DT.100773131  DT.100667094  DT.97855036  DT.100764694  DT.102823202  DT.100667097 
    DT.121160492  DT.40288357  DT.91705626  DT.95147878  DT.100862869  DT.102823203  DT.121160486  DT.121160502 
    DT.121160528  DT.121160573  DT.91929372  DT.91988142  DT.95147884  DT.99997137  DT.95263106 

    24/42 AceView cDNA sequences (see all 42):

    BI059777 AK055092 CR614381 BC011355 BC009741 BC030157 BC017337 CR604474 
    CR610972 CK902158 CK821755 AY007123 AJ420443 BX434299 Z28491 AK097295 
    AK000194 CK902159 AK024510 BX457189 AI907399 BC006409 AW901000 AA837430 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C5 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a ·
    SP1:                                                                                            -     -                                                         
    SP2:                                                        -     -     -     -     -     -     -     -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                        -     -     -                       -     -                                                         
    SP5:                                                                                -           -     -                                                         

    ExUns: 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
    SP1:                          -     -           -               
    SP2:                                                            
    SP3:                          -     -                           
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for GTF3C5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GTF3C5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTCACGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GTF3C5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GTF3C5

    SOURCE GeneReport for Unigene cluster: Hs.495417
        SABiosciences Custom PCR Arrays for GTF3C5
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTF3C5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GTF3C5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF3C5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF3C5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GTF3C5 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf3c51 , 5 general transcription factor IIIC, polypeptide 51, 5 83.89(n)1
    85.58(a)1
      2 (19.38 cM)5
    702391  NM_148928.21  NP_683730.11 
     285663115 
    chicken
    (Gallus gallus)
    Aves GTF3C51 general transcription factor IIIC, polypeptide 5, 63kDa 74.71(n)
    74.83(a)
      417164  NM_001030684.1  NP_001025855.1 
    lizard
    (Anolis carolinensis)
    Reptilia GTF3C56
    --
    74(a)
    1 ↔ 1
    AAWZ02037281(917-3083)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41792 Xenopus laevis transcribed sequence with weak similarity more 79.75(n)    BX849560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.171622 Danio rerio, clone IMAGE2600619, mRNA 74.93(n)    BC044365.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)37Cd1 lethal (2) 37Cd 44.71(n)
    30.82(a)
      35193  NM_136103.2  NP_609947.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T02C12.31 Protein T02C12.3 40.38(n)
    31.33(a)
      175520  NM_065407.2  NP_497808.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G244501 Transcription factor IIIC, subunit 5 40.79(n)
    28.62(a)
      832516  NM_122353.4  NP_197833.2 
    rice
    (Oryza sativa)
    Liliopsida --
    expressed protein
    17(a)
    1 ↔ 1
    1(18978396-18988498)


    ENSEMBL Gene Tree for GTF3C5 (if available)
    TreeFam Gene Tree for GTF3C5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/583 NCBI SNPs in GTF3C5 are shown (see all 583    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735563811,2
    C,--105427383(+) ATGCCG/AGAGGT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1163743141,2
    F,--135904063(+) GAAATC/TACAGG 2 -- us2k11Minor allele frequency- T:0.05WA 118
    rs46315821,2
    A,--135904074(+) CTGGGC/AACGGT 2 -- us2k13Minor allele frequency- A:0.08NA 124
    rs1135299531,2
    C,--135904239(+) CTACCC/TGGGAG 2 -- us2k13Minor allele frequency- T:0.04NA EA 242
    rs1456630611,2
    --135904258(+) AGGAGA/CATCGC 2 -- us2k10--------
    rs8041651,2
    C,F,A,--135904266(+) CGCTTA/GTACCA 2 -- us2k19Minor allele frequency- G:0.32NA WA CSA EA 371
    rs1131224341,2
    C,F,--135904282(+) TCGGAG/AGTTGC 2 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs8041661,2
    C,F,A,H,--135904340(+) GGCTCT/CGTCTC 2 -- us2k18Minor allele frequency- C:0.28NA WA CSA EA 253
    rs1891716381,2
    --135904508(+) TTCGGC/GGCTGC 2 -- us2k10--------
    rs1808703531,2
    --135904509(+) TCGGGA/GCTGCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GTF3C5 (135906062 - 135933890 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for GTF3C5
         4 CNVs: 36924 96328 59514 83207

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF3C5
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF3C5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GTF3C5 for disorders           About GeneDecksing

    OMIM gene information: 604890    OMIM disorders: --

    2 diseases for GTF3C5:    About MalaCards
    immunodeficiency    malaria

    Human Genome Epidemiology (HuGE) Navigator: GTF3C5 (3 documents)

    Export disorders for GTF3C5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GTF3C5 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with GTF3C5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PubMed id 10373544)1, 2, 3 Hsieh Y.-J.... Roeder R.G. (1999)
    2. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PubMed id 17409385)1, 2, 9 Dumay-Odelot H.... Teichmann M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9328 HGNC: 4668 AceView: GTF3C5 Ensembl:ENSG00000148308 euGenes: HUgn9328
    ECgene: GTF3C5 H-InvDB: GTF3C5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GTF3C5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GTF3C5 gene:
    Search GeneIP for patents involving GTF3C5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for GTF3C5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GTF3C5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTF3C5  
     OriGene Protein Over-expression Lysate for GTF3C5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for GTF3C5   OriGene 3'-UTR Clone for GTF3C5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for GTF3C5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GTF3C5   OriGene Custom Protein Services for GTF3C5  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GTF3C5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF3C5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF3C5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GTF3C5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF3C5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF3C5
     GenScript Custom Purified and Recombinant Proteins Services for GTF3C5 GenScript cDNA clones with any tag delivered in your preferred vector for GTF3C5
     GenScript Custom Assay Services for GTF3C5 GenScript Custom Superior Antibodies Services for GTF3C5
     GenScript Custom overexpressing Cell Line Services for GTF3C5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GTF3C5 promoter
     Search Chromatin IP Primers for GTF3C5
     RT2 qPCR Primer Assay in human, mouse, rat GTF3C5
     GNC Network for GTF3C5
     SABiosciences PCR Arrays including human, mouse, rat GTF3C5
     Search Tocris compounds for GTF3C5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GTF3C5 antibodies
     GTF3C5 proteins
     GTF3C5 lysates
     Search for Antibodies for GTF3C5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for GTF3C5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     GTF3C5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for GTF3C5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C5
     SwitchGear 3'UTR luciferase reporter plasmids for GTF3C5
     SwitchGear Promoter luciferase reporter plasmids for GTF3C5
     Search ThermoFisher Antibodies for GTF3C5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C5
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GTF3C5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4