Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GTF3C5 Gene

Aliases for GTF3C5 Gene

  • General Transcription Factor IIIC Subunit 5 2 3 5
  • General Transcription Factor IIIC, Polypeptide 5, 63kDa 2 3
  • Transcription Factor IIIC Subunit Epsilon 3 4
  • Transcription Factor IIIC 63 KDa Subunit 3 4
  • Transcription Factor IIIC, 63 KD 2 3
  • TFIIIC 63 KDa Subunit 3 4
  • TF3C-Epsilon 3 4
  • TFIIIC63 3 4
  • General Transcription Factor IIIC, Polypeptide 5 (63kD) 2
  • General Transcription Factor 3C Polypeptide 5 3
  • TFIIICepsilon 3
  • TFiiiC2-63 3

External Ids for GTF3C5 Gene

Previous GeneCards Identifiers for GTF3C5 Gene

  • GC09P126930
  • GC09P127462
  • GC09P129259
  • GC09P131182
  • GC09P132935
  • GC09P134895
  • GC09P135906
  • GC09P105399

Summaries for GTF3C5 Gene

GeneCards Summary for GTF3C5 Gene

GTF3C5 (General Transcription Factor IIIC Subunit 5) is a Protein Coding gene. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for GTF3C5 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Gene Wiki entry for GTF3C5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C5 Gene

Genomics for GTF3C5 Gene

Regulatory Elements for GTF3C5 Gene

Enhancers for GTF3C5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F133080 1 Ensembl ENCODE 13.2 +50.9 50945 2.6 HDAC1 KLF1 ZNF175 RELA SCRT2 ZNF639 ZNF740 L3MBTL2 BHLHE40 NR4A1 GTF3C5 CELP RALGDS GC09M133093
GH09F133083 0.2 Ensembl 13.2 +52.8 52826 0.2 HDAC1 KLF17 MLLT1 CEL GTF3C5 CELP GC09M133093
GH09F133008 0.2 ENCODE 11 -21.6 -21647 0.1 HDAC1 PKNOX1 FOXA3 HLF CEBPB ARID1B NFIL3 SMARCA4 PBX2 IKZF1 RNU7-21P RPL39P24 GTF3C5 CEL GC09P133045 GC09P133069 GC09P133080 GC09P133081 GC09P132965
GH09F133029 0.2 ENCODE 8.1 +0.0 32 2.5 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TTF1 SETX SURF6 SURF4 RALGDS GTF3C5 CEL MIR6877
GH09F133054 1.3 Ensembl ENCODE 6.9 +27.5 27549 8.2 HDAC1 PKNOX1 THRB SCRT2 EGR2 ZNF263 CEBPB ZEB2 REST SMARCA4 CEL RALGDS GTF3C5 LOC100996574 MIR6877
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GTF3C5 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001316695 125 2801 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for GTF3C5 Gene

Chromosome:
9
Start:
133,030,675 bp from pter
End:
133,058,503 bp from pter
Size:
27,829 bases
Orientation:
Plus strand

Genomic View for GTF3C5 Gene

Genes around GTF3C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C5 Gene

Proteins for GTF3C5 Gene

  • Protein details for GTF3C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q8-TF3C5_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 5
    Protein Accession:
    Q9Y5Q8
    Secondary Accessions:
    • A6NI44
    • A6NJB9
    • Q5T7U2
    • Q5T7U3
    • Q8N2U7
    • Q8N857
    • Q96GD9
    • Q9H4P2

    Protein attributes for GTF3C5 Gene

    Size:
    519 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.

    Alternative splice isoforms for GTF3C5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C5 Gene

Post-translational modifications for GTF3C5 Gene

  • Ubiquitination at Lys 38, Lys 256, and Lys 367
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C5 Gene

Domains & Families for GTF3C5 Gene

Gene Families for GTF3C5 Gene

Protein Domains for GTF3C5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q8

UniProtKB/Swiss-Prot:

TF3C5_HUMAN :
  • Belongs to the TFIIIC subunit 5 family.
Family:
  • Belongs to the TFIIIC subunit 5 family.
genes like me logo Genes that share domains with GTF3C5: view

Function for GTF3C5 Gene

Molecular function for GTF3C5 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Gene Ontology (GO) - Molecular Function for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IEA,IC 17409385
GO:0005515 protein binding IPI 17409385
genes like me logo Genes that share ontologies with GTF3C5: view
genes like me logo Genes that share phenotypes with GTF3C5: view

Animal Models for GTF3C5 Gene

MGI Knock Outs for GTF3C5:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF3C5 Gene

Localization for GTF3C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C5 Gene COMPARTMENTS Subcellular localization image for GTF3C5 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C5: view

Pathways & Interactions for GTF3C5 Gene

genes like me logo Genes that share pathways with GTF3C5: view

Gene Ontology (GO) - Biological Process for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006383 transcription from RNA polymerase III promoter IC 17409385
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter IC 17409385
GO:0042797 tRNA transcription from RNA polymerase III promoter IC 17409385
genes like me logo Genes that share ontologies with GTF3C5: view

No data available for SIGNOR curated interactions for GTF3C5 Gene

Transcripts for GTF3C5 Gene

Unigene Clusters for GTF3C5 Gene

General transcription factor IIIC, polypeptide 5, 63kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - -
SP2: - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - -
SP11:
SP12: - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - - - - - - -
SP15: - - - - - - - - -
SP16: - - -

ExUns: 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for GTF3C5 Gene

GeneLoc Exon Structure for
GTF3C5
ECgene alternative splicing isoforms for
GTF3C5

Expression for GTF3C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF3C5 Gene

Protein differential expression in normal tissues from HIPED for GTF3C5 Gene

This gene is overexpressed in Lung (28.2), Peripheral blood mononuclear cells (7.7), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C5 Gene



Protein tissue co-expression partners for GTF3C5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF3C5 Gene:

GTF3C5

SOURCE GeneReport for Unigene cluster for GTF3C5 Gene:

Hs.495417
genes like me logo Genes that share expression patterns with GTF3C5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C5 Gene

Orthologs for GTF3C5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3C5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C5 34 35
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia GTF3C5 34 35
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia GTF3C5 34 35
  • 85.32 (n)
mouse
(Mus musculus)
Mammalia Gtf3c5 34 16 35
  • 83.69 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c5 34
  • 83.5 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF3C5 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C5 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C5 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C5 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c5 34
  • 70.31 (n)
Str.13723 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4179 34
zebrafish
(Danio rerio)
Actinopterygii gtf3c5 34 35
  • 59.69 (n)
Dr.17162 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009321 34
  • 45.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cd 34 35
  • 44.53 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_T02C12.3 34
  • 40.78 (n)
tftc-5 35
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for GTF3C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF3C5 Gene

ENSEMBL:
Gene Tree for GTF3C5 (if available)
TreeFam:
Gene Tree for GTF3C5 (if available)

Paralogs for GTF3C5 Gene

No data available for Paralogs for GTF3C5 Gene

Variants for GTF3C5 Gene

Sequence variations from dbSNP and Humsavar for GTF3C5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1047780 -- 133,058,408(+) GGCAA(A/G)AAGTG utr-variant-3-prime
rs1047844 -- 133,043,785(+) TACGT(C/T)AATGT intron-variant, reference, missense
rs10584022 -- 133,058,645(+) GCCCC(-/CC)TCACA downstream-variant-500B
rs111282330 -- 133,037,712(+) AGAAA(C/T)TTAAC intron-variant
rs111287805 -- 133,031,146(+) GGCGG(C/T)GAGGA intron-variant, upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for GTF3C5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
esv2761264 CNV loss 21179565
esv3621930 CNV loss 21293372
nsv466606 CNV loss 19166990
nsv508564 CNV deletion 20534489
nsv520759 CNV loss 19592680
nsv615596 CNV loss 21841781
nsv6746 CNV insertion 18451855
nsv819112 CNV gain 19587683
nsv831744 CNV gain+loss 17160897

Variation tolerance for GTF3C5 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C5 Gene

Disorders for GTF3C5 Gene

Relevant External Links for GTF3C5

Genetic Association Database (GAD)
GTF3C5
Human Genome Epidemiology (HuGE) Navigator
GTF3C5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C5

No disorders were found for GTF3C5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C5 Gene

Publications for GTF3C5 Gene

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 3 4 22 64
  2. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GTF3C5 Gene

Sources for GTF3C5 Gene

Content
Loading form....