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GTF3C4 Gene

protein-coding   GIFtS: 55
GCID: GC09P135545

General Transcription Factor IIIC, Polypeptide 4, 90kDa

(Previous names: general transcription factor IIIC, polypeptide 4 (90kD))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
General Transcription Factor IIIC, Polypeptide 4, 90kDa1 2     KAT122
Transcription Factor IIIC 90 KDa Subunit2 3     TFIII902
Transcription Factor IIIC Subunit Delta2 3     TFIIIC2902
TF3C-delta2 3     TFIIICDELTA2
TFIIIC902 3     General Transcription Factor 3C 42
TFIIIC 90 KDa Subunit2 3     General Transcription Factor 3C Polypeptide 42
General Transcription Factor IIIC, Polypeptide 4 (90kD)1     EC 2.3.1.483

External Ids:    HGNC: 46671   Entrez Gene: 93292   Ensembl: ENSG000001254847   OMIM: 6048925   UniProtKB: Q9UKN83   

Export aliases for GTF3C4 gene to outside databases

Previous GC identifers: GC09P126570 GC09P127102 GC09P128899 GC09P130821 GC09P132574 GC09P134535 GC09P105039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GTF3C4 Gene:
GTF3C4 (general transcription factor IIIC, polypeptide 4, 90kDa) is a protein-coding gene. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8
Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S
RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase
activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the
recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be
localized close to the A box

Gene Wiki entry for GTF3C4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF3C4 gene promoter:
         Nkx2-2   YY1   C/EBPalpha   E47   E2F   E2F-1   POU2F1   POU2F1a   Hand1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF3C4 promoter sequence
   Search Chromatin IP Primers for GTF3C4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF3C4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.3

GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3C4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P135545:  view genomic region     (about GC identifiers)

Start:
135,545,422 bp from pter      End:
135,570,342 bp from pter
Size:
24,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8 (See protein sequence)
Recommended Name: General transcription factor 3C polypeptide 4  
Size: 822 amino acids; 91982 Da
Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5
and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F
Sequence caution: Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q5VZJ7

Explore the universe of human proteins at neXtProt for GTF3C4: NX_Q9UKN8

Explore proteomics data for GTF3C4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys123, Lys225, Lys364, Lys467, Lys807
  • Modification sites at PhosphoSitePlus

  • See GTF3C4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036336.2  
    ENSEMBL proteins: 
     ENSP00000431378   ENSP00000361219  
    Reactome Protein details: Q9UKN8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KAT: Chromatin-modifying enzymes / K-acetyltransferases
    GTF: General transcription factors

    3 InterPro protein domains:
     IPR024764 TFIIIC_Znf
     IPR024761 TFIIIC_delta_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKN8

    ProtoNet protein and cluster: Q9UKN8

    UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8
    Similarity: Belongs to the TFIIIC subunit 4 family


    Find genes that share domains with GTF3C4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF3C4_HUMAN, Q9UKN8
    Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S
    RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase
    activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the
    recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be
    localized close to the A box
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Enzyme Number (IUBMB): EC 2.3.1.481

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677contributes to DNA binding IC17409385
    GO:0004402histone acetyltransferase activity IEA--
    GO:0005515protein binding IPI17409385
    GO:0008047enzyme activator activity TAS10523658
         
    Find genes that share ontologies with GTF3C4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GTF3C4:
     Increased S DNA content  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF3C4
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    miRNA
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    miRTarBase miRNAs that target GTF3C4:
    hsa-mir-331-3p (MIRT043336), hsa-let-7b-5p (MIRT032467), hsa-mir-30a-5p (MIRT028677), hsa-mir-16-5p (MIRT031966), hsa-mir-320a (MIRT044408), hsa-mir-615-3p (MIRT039620)

    Block miRNA regulation of human, mouse, rat GTF3C4 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GTF3C4:
    hsa-miR-4303 hsa-miR-505 hsa-miR-4307 hsa-miR-3155 hsa-miR-484 hsa-miR-141* hsa-miR-642b hsa-miR-3155b
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C4 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TF3C4_HUMAN, Q9UKN8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000127transcription factor TFIIIC complex IDA17409385
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with GTF3C4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF3C4 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 1 Promoter0.77
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
    RNA Polymerase III Transcription0.88
    2Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex0.00
    Transcription of tRNA
    3RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    4Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with GTF3C4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF3C4
        Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex

    3 Reactome Pathways for GTF3C4
        RNA Polymerase III Transcription Initiation From Type 1 Promoter
    RNA Polymerase III Transcription Initiation From Type 2 Promoter
    RNA Polymerase III Abortive And Retractive Initiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF3C4
    Interactions:

        GeneGlobe Interaction Network for GTF3C4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF3C4 (Q9UKN82, 3 ENSP000003612194) via UniProtKB, MINT, STRING, and/or I2D (see all 691)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF3C3Q9Y5Q92, 3, ENSP000002639564MINT-7945693 I2D: score=1 STRING: ENSP00000263956
    HIST2H3AQ71DI33, ENSP000003854794I2D: score=2 STRING: ENSP00000385479
    GTF3C1Q127892, 3, ENSP000003485104MINT-7945693 MINT-6488791 I2D: score=2 STRING: ENSP00000348510
    HIST2H3DQ71DI33, ENSP000003332774I2D: score=2 STRING: ENSP00000333277
    HIST2H3CQ71DI33I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IC17409385
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0006384transcription initiation from RNA polymerase III promoter TAS10523658
    GO:0010467gene expression TAS--
    GO:0016573histone acetylation TAS10523658

    Find genes that share ontologies with GTF3C4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF3C4 (TF3C4)

    2 HMDB Compounds for GTF3C4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GTF3C4 gene: 
    NM_012204.2  

    Unigene Cluster for GTF3C4:

    General transcription factor IIIC, polypeptide 4, 90kDa
    Hs.656646  [show with all ESTs]
    Unigene Representative Sequence: NM_012204
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483873 ENST00000372146(uc010mzv.3 uc010mzw.3)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate GTF3C4:
    hsa-miR-4303 hsa-miR-505 hsa-miR-4307 hsa-miR-3155 hsa-miR-484 hsa-miR-141* hsa-miR-642b hsa-miR-3155b
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat GTF3C4
      QuantiFast Probe-based Assays in human, mouse, rat GTF3C4

    Additional mRNA sequence: 

    AF086460.1 AF142328.1 AJ420451.1 AK024655.1 AK027509.1 AK126436.1 BC011619.2 BC022787.1 
    BC060821.1 BC094774.1 BC104755.1 BC112245.1 

    9 DOTS entries:

    DT.101978566  DT.100707633  DT.97841365  DT.95259571  DT.97816401  DT.40111373  DT.91717779  DT.95225516 
    DT.97803439 

    Selected AceView cDNA sequences (see all 202):

    AA587653 Z44435 AA627475 AW297811 AK027509 BQ233577 AF086460 AA429809 
    AI457895 BU178871 BU632842 H88620 AI078049 AW043778 AW450958 AK024655 
    BC022787 AI184450 BI870766 BQ002223 AV726942 BE019328 AA732790 BQ004332 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF3C4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAACAGAA
    GTF3C4 Expression
    About this image

    GTF3C4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF3C4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656646
        Custom PCR Arrays for GTF3C4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GTF3C4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf3c41 , 5 general transcription factor IIIC, polypeptide 41, 5 87.52(n)1
    93.51(a)1
      2 (19.38 cM)5
    2692521  NM_172977.31  NP_766565.21 
     288223055 
    chicken
    (Gallus gallus)
    Aves GTF3C41 general transcription factor IIIC, polypeptide 4, 90kDa less 79.71(n)
    87.6(a)
      417167  XM_415450.4  XP_415450.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145762 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_036336.1 (H.sapiens) general transcription factor IIIC, polypeptide 4 (90kD) [Homo sapiens] less 73.96(n)    BJ060086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.102452 Transcribed sequence with weak similarity to protein refNP_036336.1 (H.sapiens) general transcription factor IIIC, polypeptide 4 (90kD) [Homo sapiens] less 72.79(n)    57065365 


    ENSEMBL Gene Tree for GTF3C4 (if available)
    TreeFam Gene Tree for GTF3C4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GTF3C4 (see all 405)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs4154101,2
    C,F,O,A,H--135547839(+) CCAGGC/TGGCAG 1 -- int120Minor allele frequency- N:0.00EA NA NS WA CSA 1418
    rs722262851,2
    C--135547891(+) GAACA-/TAAT  
            
    TAATT
    1 -- int10--------
    rs592718091,2
    C--135547893(+) AATTA-/ATTA  
            
    TTGTT
    1 -- int10--------
    rs2013761621,2
    C--135547893(+) ACATAA/CTTAAT 1 -- int10--------
    rs1837955071,2
    --135547925(+) TCAGTA/CCATGA 1 -- int10--------
    rs1879186621,2
    --135548029(+) GAAGTA/CTTTAA 1 -- int10--------
    rs1913042551,2
    --135548101(+) AGAGGC/TAAGAA 1 -- int10--------
    rs1826828351,2
    C--135548333(+) TTGGGA/GGGCCG 1 -- int10--------
    rs802971521,2
    C--135548551(+) GGCGAA/CAGAGC 1 -- int10--------
    rs1998634071,2
    --135548569(+) GTCTC-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for GTF3C4 (135545422 - 135570342 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GTF3C4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF3C4
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF3C4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604892    OMIM disorders: --


    Find genes that share disorders with GTF3C4           About GenesLikeMe

    Genetic Association Database (GAD): GTF3C4
    Human Genome Epidemiology (HuGE) Navigator: GTF3C4 (1 document)

    Export disorders for GTF3C4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF3C4 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with GTF3C4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PubMed id 10523658)1, 2, 3 Hsieh Y.-J.... Roeder R.G. (Mol. Cell. Biol. 1999)
    2. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PubMed id 17409385)1, 2 Dumay-Odelot H.... Teichmann M. (J. Biol. Chem. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9329 HGNC: 4667 AceView: GTF3C4 Ensembl:ENSG00000125484 euGenes: HUgn9329
    ECgene: GTF3C4 H-InvDB: GTF3C4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF3C4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF3C4 gene:
    Search GeneIP for patents involving GTF3C4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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