Aliases for GTF3C4 Gene
Aliases for GTF3C4 Gene
- General Transcription Factor IIIC Subunit 4 2 3 5
- General Transcription Factor IIIC, Polypeptide 4, 90kDa 2 3
- Transcription Factor IIIC 90 KDa Subunit 3 4
- Transcription Factor IIIC Subunit Delta 3 4
- TFIIIC 90 KDa Subunit 3 4
- TF3C-Delta 3 4
- TFIIIC90 3 4
- General Transcription Factor IIIC, Polypeptide 4 (90kD) 2
External Ids for GTF3C4 Gene
- HGNC: 4667
- Entrez Gene: 9329
- Ensembl: ENSG00000125484
- OMIM: 604892
- UniProtKB: Q9UKN8
Previous GeneCards Identifiers for GTF3C4 Gene
- GC09P126570
- GC09P127102
- GC09P128899
- GC09P130821
- GC09P132574
- GC09P134535
- GC09P135545
- GC09P105039
Summaries for GTF3C4 Gene
GeneCards Summary for GTF3C4 Gene
GTF3C4 (General Transcription Factor IIIC Subunit 4) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.
UniProtKB/Swiss-Prot for GTF3C4 Gene
-
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C4 Gene
Genomics for GTF3C4 Gene
Regulatory Elements for GTF3C4 Gene
Enhancers for GTF3C4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GTF3C4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GTF3C4 gene promoter:
Regulatory Element Products
Genomic Location for GTF3C4 Gene
- Chromosome:
- 9
- Start:
- 132,670,035 bp from pter
- End:
- 132,694,955 bp from pter
- Size:
- 24,921 bases
- Orientation:
- Plus strand
Genomic View for GTF3C4 Gene
Genes around GTF3C4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.13 by Ensembl
- 9q34.13 by Entrez Gene
- 9q34.13 by HGNC
GTF3C4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GTF3C4 Gene
Proteins for GTF3C4 Gene
-
Protein details for GTF3C4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKN8-TF3C4_HUMAN
- Recommended name:
- General transcription factor 3C polypeptide 4
- Protein Accession:
- Q9UKN8
- Q5VZJ7
Protein attributes for GTF3C4 Gene
- Size:
- 822 amino acids
- Molecular mass:
- 91982 Da
- Quaternary structure:
-
- Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
- SequenceCaution:
-
- Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for GTF3C4 Gene
Post-translational modifications for GTF3C4 Gene
Other Protein References for GTF3C4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GTF3C4
- Novus Biologicals Antibodies for GTF3C4
-
Abcam antibodies for GTF3C4
- Invitrogen Antibodies for GTF3C4
- GeneTex GTF3C4 antibody for GTF3C4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GTF3C4
- Origene Custom Protein Services for GTF3C4
- Novus Biologicals proteins for GTF3C4
- Search GeneTex for Proteins for GTF3C4
-
Abcam proteins for GTF3C4
Assay Products
No data available for DME Specific Peptides for GTF3C4 Gene
Domains & Families for GTF3C4 Gene
Gene Families for GTF3C4 Gene
Protein Domains for GTF3C4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GTF3C4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UKN8- Family:
-
- Belongs to the TFIIIC subunit 4 family.
Function for GTF3C4 Gene
Molecular function for GTF3C4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Acetyl-CoA + [histone] = CoA + acetyl-[histone].
- UniProtKB/Swiss-Prot Function:
- Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Enzyme Numbers (IUBMB) for GTF3C4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | contributes_to DNA binding | IC,IEA | 17409385 |
| GO:0004402 | histone acetyltransferase activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | 17409385 |
| GO:0008047 | enzyme activator activity | TAS | 10523658 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for GTF3C4 Gene
- GenomeRNAi human phenotypes for GTF3C4:
-
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Model Products
-
Taconic Biosciences Mouse Models for GTF3C4
-
ViGene Biosciences lentiviral particle packaged cDNA for GTF3C4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF3C4 gene
- Search ViGene Biosciences for GTF3C4
CRISPR Products
-
OriGene CRISPR knockouts for GTF3C4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GTF3C4
- GenScript: Design CRISPR guide RNA sequences for GTF3C4
miRNA for GTF3C4 Gene
- miRTarBase miRNAs that target GTF3C4
-
- hsa-mir-30a-5p (MIRT028677)
- hsa-mir-16-5p (MIRT031966)
- hsa-let-7b-5p (MIRT032467)
- hsa-mir-615-3p (MIRT039620)
- hsa-mir-331-3p (MIRT043336)
- hsa-mir-320a (MIRT044408)
- hsa-let-7e-3p (MIRT227803)
- hsa-mir-571 (MIRT227804)
- hsa-mir-3173-3p (MIRT227806)
- hsa-mir-4259 (MIRT227807)
- hsa-mir-4428 (MIRT227809)
- hsa-mir-4477b (MIRT227810)
- hsa-mir-6891-5p (MIRT227812)
- hsa-mir-875-3p (MIRT240700)
- hsa-mir-489-3p (MIRT563542)
- hsa-let-7d-3p (MIRT563543)
- hsa-mir-3913-3p (MIRT563544)
- hsa-mir-873-5p (MIRT563545)
- hsa-mir-1299 (MIRT684312)
- hsa-mir-642a-5p (MIRT684313)
- hsa-mir-4487 (MIRT684314)
- hsa-mir-558 (MIRT684315)
- hsa-mir-3160-3p (MIRT684316)
- hsa-mir-6846-3p (MIRT684317)
- hsa-mir-494-3p (MIRT684318)
- hsa-mir-6128 (MIRT684319)
- hsa-mir-6751-3p (MIRT684320)
- hsa-mir-1199-5p (MIRT684321)
- hsa-mir-1251-5p (MIRT684322)
- hsa-mir-3925-3p (MIRT684323)
- hsa-mir-766-3p (MIRT684324)
- hsa-mir-1304-3p (MIRT684325)
- hsa-mir-6769b-3p (MIRT684326)
- hsa-mir-4723-3p (MIRT684327)
- hsa-mir-3183 (MIRT684328)
- hsa-mir-4308 (MIRT684329)
- hsa-mir-2276-5p (MIRT684330)
- hsa-mir-6892-3p (MIRT684331)
- hsa-mir-1324 (MIRT684332)
- hsa-mir-1182 (MIRT684333)
- hsa-mir-3184-3p (MIRT684334)
- hsa-mir-3646 (MIRT684335)
miRNA Products
- Search ViGene Biosciences for GTF3C4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GTF3C4
- Browse OriGene Inhibitory RNA Products For GTF3C4
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF3C4 gene
Clone Products
-
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GTF3C4 gene
-
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-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C4 Gene
Localization for GTF3C4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GTF3C4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000127 | transcription factor TFIIIC complex | IDA | 17409385 |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005739 | mitochondrion | IDA | -- |
Pathways & Interactions for GTF3C4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA Polymerase III Transcription Initiation | ||
| 2 | Transcription of tRNA | ||
| 3 | Gene Expression |
.48
|
|
| 4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
Pathways by source for GTF3C4 Gene
2 Qiagen pathways for GTF3C4 Gene
Interacting Proteins for GTF3C4 Gene
Selected Interacting proteins:
Q9UKN8-TF3C4_HUMAN
ENSP00000361219
for GTF3C4 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IC | 17409385 |
| GO:0006383 | transcription from RNA polymerase III promoter | IC | 17409385 |
| GO:0006384 | transcription initiation from RNA polymerase III promoter | TAS | 10523658 |
| GO:0016573 | histone acetylation | IEA | -- |
| GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter | IC | 17409385 |
No data available for SIGNOR curated interactions for GTF3C4 Gene
Drugs & Compounds for GTF3C4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Coenzyme A | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| acetyl-coa |
|
72-89-9 |
|
Transcripts for GTF3C4 Gene
mRNA/cDNA for GTF3C4 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (202) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GTF3C4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GTF3C4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GTF3C4
- GenScript: Design CRISPR guide RNA sequences for GTF3C4
miRNA Products
- Search ViGene Biosciences for GTF3C4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GTF3C4
- Browse OriGene Inhibitory RNA Products For GTF3C4
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF3C4 gene
Clone Products
-
OriGene ORF clones in human for GTF3C4
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for GTF3C4 Gene
This gene is overexpressed in Cerebrospinal fluid (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GTF3C4 Gene:
GTF3C4SOURCE GeneReport for Unigene cluster for GTF3C4 Gene:
Hs.656646Evidence on tissue expression from TISSUES for GTF3C4 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for GTF3C4
-
OriGene qPCR primer pairs for GTF3C4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C4 Gene
Orthologs for GTF3C4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GTF3C4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GTF3C4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GTF3C4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Gtf3c4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gtf3c4 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GTF3C4 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GTF3C4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GTF3C4 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gtf3c4 34 |
|
||
| Str.14605 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14576 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gtf3c4 34 35 |
|
||
| Dr.10245 34 |
|
- Species where no ortholog for GTF3C4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GTF3C4 Gene
No data available for Paralogs for GTF3C4 Gene
Variants for GTF3C4 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000216176 | -- | 132,686,131(+) | TGAGA(C/T)TGGGG | intron-variant | |
| rs1000751178 | -- | 132,685,937(+) | AAACC(C/G)TGACG | intron-variant | |
| rs1000778802 | -- | 132,695,087(+) | GAGGG(A/C)AGTGT | downstream-variant-500B | |
| rs1000831683 | -- | 132,668,422(+) | TGAAA(A/C)AAACG | intron-variant, upstream-variant-2KB | |
| rs1000938799 | -- | 132,676,112(+) | GCCAG(-/GATGGTCTC)GATCT | intron-variant |
Residual Variation Intolerance Score:
14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.75;
33.19% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GTF3C4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GTF3C4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3C4 Gene
Disorders for GTF3C4 Gene
Relevant External Links for GTF3C4
No disorders were found for GTF3C4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C4 Gene
Publications for GTF3C4 Gene
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PMID: 10523658) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4 64
- Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M. … Liu Q. (Oncogenesis 2017) 3 64
- SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. (PMID: 26511642) Wang M. … Yi J. (Protein Cell 2016) 3 64
Products for GTF3C4 Gene
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- Abcam antibodies for GTF3C4
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- VectorBuilder custom plasmid, inducible vectors for GTF3C4
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GTF3C4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
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