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GTF3C4 Gene

protein-coding GIFtS: 55
GCID: GC09P135545

General Transcription Factor IIIC, Polypeptide 4, 90kDa

(Previous names: general transcription factor IIIC, polypeptide 4 (90kD))

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
General Transcription Factor IIIC, Polypeptide 4, 90kDa¹ ²		KAT12²
Transcription Factor IIIC 90 KDa Subunit² ³		TFIII90²
Transcription Factor IIIC Subunit Delta² ³		TFIIIC290²
TF3C-delta² ³		TFIIICDELTA²
TFIIIC90² ³		General Transcription Factor 3C 4²
TFIIIC 90 KDa Subunit² ³		General Transcription Factor 3C Polypeptide 4²
General Transcription Factor IIIC, Polypeptide 4 (90kD)¹		EC 2.3.1.48³

External Ids:	HGNC: 4667¹	Entrez Gene: 9329²	Ensembl: ENSG00000125484⁷	OMIM: 604892⁵	UniProtKB: Q9UKN8³

Export aliases for GTF3C4 gene to outside databases

Previous GC identifers: GC09P126570 GC09P127102 GC09P128899 GC09P130821 GC09P132574 GC09P134535 GC09P105039

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GTF3C4 Gene:

GTF3C4 (general transcription factor IIIC, polypeptide 4, 90kDa) is a protein-coding gene. Diseases associated with GTF3C4 include hiv-1, and multiple myeloma. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8

Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S

RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase

activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the

recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be

localized close to the A box

Gene Wiki entry for GTF3C4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000009.12 NC_018920.2 NT_008470.20

Regulatory elements:

Regulatory transcription factor binding sites in the GTF3C4 gene promoter:
Nkx2-2 YY1 C/EBPalpha E47 E2F E2F-1 POU2F1 POU2F1a Hand1 ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GTF3C4 promoter sequence

Search Chromatin IP Primers for GTF3C4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF3C4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34.3

GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3C4 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P135545: view genomic region (about GC identifiers)

Start:	135,545,422 bp from pter	End:	135,570,342 bp from pter
Size:	24,921 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8 (See protein sequence)

Recommended Name: General transcription factor 3C polypeptide 4

Size: 822 amino acids; 91982 Da

Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5

and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F

Sequence caution: Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence;

Secondary accessions: Q5VZJ7

Explore the universe of human proteins at neXtProt for GTF3C4: NX_Q9UKN8

Explore proteomics data for GTF3C4 at MOPED

Post-translational modifications:

Ubiquitination² at Lys123, Lys225, Lys364, Lys467, Lys807

Modification sites at PhosphoSitePlus

See GTF3C4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036336.2

ENSEMBL proteins:

ENSP00000431378 ENSP00000361219

Reactome Protein details: Q9UKN8

GTF3C4 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

KAT: Chromatin-modifying enzymes / K-acetyltransferases

GTF: General transcription factors

3 InterPro protein domains:

IPR024764 TFIIIC_Znf

IPR024761 TFIIIC_delta_N

IPR017986 WD40_repeat_dom

Graphical View of Domain Structure for InterPro Entry Q9UKN8

ProtoNet protein and cluster: Q9UKN8

UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8

Similarity: Belongs to the TFIIIC subunit 4 family

GTF3C4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TF3C4_HUMAN, Q9UKN8

Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S

RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase

activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the

recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be

localized close to the A box

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

Enzyme Number (IUBMB): EC 2.3.1.48¹

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	contributes to DNA binding	IC	17409385
GO:0004402	histone acetyltransferase activity	IEA	--
GO:0005515	protein binding	IPI	17409385
GO:0008047	enzyme activator activity	TAS	10523658

GTF3C4 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for GTF3C4:

Increased S DNA content

Synthetic lethal with c-Myc af

Animal Models:

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miRNA Products:		miRTarBase miRNAs that target GTF3C4: hsa-mir-331-3p (MIRT043336), hsa-let-7b-5p (MIRT032467), hsa-mir-30a-5p (MIRT028677), hsa-mir-16-5p (MIRT031966), hsa-mir-320a (MIRT044408), hsa-mir-615-3p (MIRT039620)

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		SwitchGear 3'UTR luciferase reporter plasmid: GTF3C4 3' UTR sequence

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TF3C4_HUMAN, Q9UKN8: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2
extracellular	1
mitochondrion	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000127	transcription factor TFIIIC complex	IDA	17409385
GO:0005654	nucleoplasm	TAS	--

GTF3C4 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GTF3C4 About

See pathways by source

SuperPath

Contained pathways About

RNA Polymerase III Transcription Initiation

RNA Polymerase III Transcription Initiation	0.88	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.77
RNA Polymerase III Abortive And Retractive Initiation	0.88	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.74
RNA Polymerase III Transcription	0.88

Transcription of tRNA

Assembly of RNA Polymerase-III Initiation Complex

0.00

Transcription of tRNA

RNA Polymerase I Promoter Opening

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

0.73

Gene Expression

Gene Expression

0.40

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF3C4

	Transcription of tRNA
	Assembly of RNA Polymerase-III Initiation Complex

3 Reactome Pathways for GTF3C4

	RNA Polymerase III Transcription Initiation From Type 1 Promoter
	RNA Polymerase III Transcription Initiation From Type 2 Promoter
	RNA Polymerase III Abortive And Retractive Initiation

GTF3C4 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for GTF3C4
Interactions:

GeneGlobe Interaction Network for GTF3C4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GTF3C4 (Q9UKN8^{2, 3} ENSP00000361219⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 691)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GTF3C3	Q9Y5Q9²^,³, ENSP00000263956⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000263956
HIST2H3A	Q71DI3³, ENSP00000385479⁴	I2D: score=2 STRING: ENSP00000385479
GTF3C1	Q12789²^,³, ENSP00000348510⁴	MINT-7945693 MINT-6488791 I2D: score=2 STRING: ENSP00000348510
HIST2H3D	Q71DI3³, ENSP00000333277⁴	I2D: score=2 STRING: ENSP00000333277
HIST2H3C	Q71DI3³	I2D: score=2

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Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IC	17409385
GO:0006383	transcription from RNA polymerase III promoter	TAS	--
GO:0006384	transcription initiation from RNA polymerase III promoter	TAS	10523658
GO:0010467	gene expression	TAS	--
GO:0016573	histone acetylation	TAS	10523658

GTF3C4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for GTF3C4 (TF3C4)

2 HMDB Compounds for GTF3C4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GTF3C4 gene:

NM_012204.2

Unigene Cluster for GTF3C4:

General transcription factor IIIC, polypeptide 4, 90kDa

Hs.656646 [show with all ESTs]

Unigene Representative Sequence: NM_012204

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483873 ENST00000372146(uc010mzv.3 uc010mzw.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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		8 qRT-PCR Assays for microRNAs that regulate GTF3C4:
		hsa-miR-4303 hsa-miR-505 hsa-miR-4307 hsa-miR-3155 hsa-miR-484 hsa-miR-141* hsa-miR-642b hsa-miR-3155b

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		QuantiFast Probe-based Assays in human, mouse, rat GTF3C4

Additional mRNA sequence:

AF086460.1 AF142328.1 AJ420451.1 AK024655.1 AK027509.1 AK126436.1 BC011619.2 BC022787.1

BC060821.1 BC094774.1 BC104755.1 BC112245.1

9 DOTS entries:

DT.101978566 DT.100707633 DT.97841365 DT.95259571 DT.97816401 DT.40111373 DT.91717779 DT.95225516

DT.97803439

Selected AceView cDNA sequences (see all 202):

AA587653 Z44435 AA627475 AW297811 AK027509 BQ233577 AF086460 AA429809

AI457895 BU178871 BU632842 H88620 AI078049 AW043778 AW450958 AK024655

BC022787 AI184450 BI870766 BQ002223 AV726942 BE019328 AA732790 BQ004332

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GTF3C4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGTAACAGAA

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GTF3C4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

GTF3C4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.656646

Custom PCR Arrays for GTF3C4

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for GTF3C4 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Gtf3c4^{1 , 5}	general transcription factor IIIC, polypeptide 4^{1, 5}	87.52(n)¹ 93.51(a)¹	2 (19.38 cM)⁵ 269252¹ NM_172977.3¹ NP_766565.2¹ 28822305⁵
chicken (Gallus gallus)	Aves	GTF3C4¹	general transcription factor IIIC, polypeptide 4, 9 more	79.71(n) 87.6(a)	417167 XM_415450.4 XP_415450.3
African clawed frog (Xenopus laevis)	Amphibia	Xl.14576²	Xenopus laevis transcribed sequence with moderate similarity more	73.96(n)	BJ060086.1
zebrafish (Danio rerio)	Actinopterygii	Dr.10245²	Transcribed sequence with weak similarity to protein more	72.79(n)	57065365

ENSEMBL Gene Tree for GTF3C4 (if available)
TreeFam Gene Tree for GTF3C4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs415410^1,2	C,F,O,A,H	--	135547839(+)	`CCAGGC/TGGCAG`	1	--	int¹		20		EA NA NS WA CSA	1418
rs72226285^1,2	C	--	135547891(+)	`GAACA-/TAAT TAATT`	1	--	int¹		0	--	--	--	--
rs59271809^1,2	C	--	135547893(+)	`AATTA-/ATTA TTGTT`	1	--	int¹		0	--	--	--	--
rs201376162^1,2	C	--	135547893(+)	`ACATAA/CTTAAT`	1	--	int¹		0	--	--	--	--
rs183795507^1,2		--	135547925(+)	`TCAGTA/CCATGA`	1	--	int¹		0	--	--	--	--
rs187918662^1,2		--	135548029(+)	`GAAGTA/CTTTAA`	1	--	int¹		0	--	--	--	--
rs191304255^1,2		--	135548101(+)	`AGAGGC/TAAGAA`	1	--	int¹		0	--	--	--	--
rs182682835^1,2	C	--	135548333(+)	`TTGGGA/GGGCCG`	1	--	int¹		0	--	--	--	--
rs80297152^1,2	C	--	135548551(+)	`GGCGAA/CAGAGC`	1	--	int¹		0	--	--	--	--
rs199863407^1,2		--	135548569(+)	`GTCTC-/AAAAAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GTF3C4 (135545422 - 135570342 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for GTF3C4: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GTF3C4

DNA2.0 Custom Variant and Variant Library Synthesis for GTF3C4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604892 OMIM disorders: --

3 diseases for GTF3C4: About MalaCards

hiv-1 multiple myeloma myeloma

GTF3C4 for disorders About GeneDecksing

Genetic Association Database (GAD): GTF3C4
Human Genome Epidemiology (HuGE) Navigator: GTF3C4 (1 document)

Export disorders for GTF3C4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GTF3C4 gene, integrated from 10 sources (see all 39):
(articles sorted by number of sources associating them with GTF3C4)

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The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PubMed id 10523658)^{1, 2, 3} Hsieh Y.-J.... Roeder R.G. (Mol. Cell. Biol. 1999)
Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PubMed id 17409385)^{1, 2} Dumay-Odelot H.... Teichmann M. (J. Biol. Chem. 2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)¹ Cloutier P.... Coulombe B. (PLoS Genet. 2013)
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)¹ Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9329	HGNC: 4667	AceView: GTF3C4	Ensembl:ENSG00000125484	euGenes: HUgn9329
ECgene: GTF3C4	H-InvDB: GTF3C4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GTF3C4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GTF3C4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GTF3C4 gene:
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GTF3C4 Gene

General Transcription Factor IIIC, Polypeptide 4, 90kDa

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GTF3C4 Gene

General Transcription Factor IIIC, Polypeptide 4, 90kDa

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