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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GTF3C4 Gene

protein-coding GIFtS: 53
GCID: GC09P135545

General Transcription Factor IIIC, Polypeptide 4, 90kDa

(Previous names: general transcription factor IIIC, polypeptide 4 (90kD))

Microbiology & Infectious Diseases Congress

Search for GTF3C4
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
General Transcription Factor IIIC, Polypeptide 4, 90kDa¹ ²		KAT12²
Transcription Factor IIIC 90 KDa Subunit² ³		TFIII90²
Transcription Factor IIIC Subunit Delta² ³		TFIIIC290²
TF3C-delta² ³		TFIIICDELTA²
TFIIIC90² ³		General Transcription Factor 3C 4²
TFIIIC 90 KDa Subunit² ³		General Transcription Factor 3C Polypeptide 4²
General Transcription Factor IIIC, Polypeptide 4 (90kD)¹		EC 2.3.1.48³

External Ids:	HGNC: 4667¹	Entrez Gene: 9329²	Ensembl: ENSG00000125484⁷	OMIM: 604892⁵	UniProtKB: Q9UKN8³

Export aliases for GTF3C4 gene to outside databases

Previous GC identifers: GC09P126570 GC09P127102 GC09P128899 GC09P130821 GC09P132574 GC09P134535 GC09P105039

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GTF3C4 Gene:

GTF3C4 (general transcription factor IIIC, polypeptide 4, 90kDa) is a protein-coding gene. Among its related super-pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8

Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA,

tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity

(HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment

of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A

box

Gene Wiki entry for GTF3C4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.2 NT_035014.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GTF3C4 gene promoter:
Nkx2-2 YY1 C/EBPalpha E47 E2F E2F-1 POU2F1 POU2F1a Hand1 ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GTF3C4 promoter sequence

Search SABiosciences Chromatin IP Primers for GTF3C4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF3C4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34.3

GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3C4 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P135545: view genomic region (about GC identifiers)

Start:	135,545,422 bp from pter	End:	135,570,342 bp from pter
Size:	24,921 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8 (See protein sequence)

Recommended Name: General transcription factor 3C polypeptide 4

Size: 822 amino acids; 91982 Da

Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and

GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F

Subcellular location: Nucleus

Sequence caution: Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence;

Secondary accessions: Q5VZJ7

Explore the universe of human proteins at neXtProt for GTF3C4: NX_Q9UKN8

Explore proteomics data for GTF3C4 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9UKN8

GTF3C4 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_036336.2

ENSEMBL proteins:

ENSP00000431378 ENSP00000361219

Reactome Protein details: Q9UKN8
Human Recombinant Protein Products for GTF3C4:

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	Cloud-Clone Corp. Proteins for GTF3C4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000127	transcription factor TFIIIC complex	IDA	17409385
GO:0005654	nucleoplasm	TAS	--

GTF3C4 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

KAT: Chromatin-modifying enzymes / K-acetyltransferases

GTF: General transcription factors

2 InterPro protein domains:

IPR024764 TFIIIC_Znf

IPR024761 TFIIIC_delta_N

Graphical View of Domain Structure for InterPro Entry Q9UKN8

ProtoNet protein and cluster: Q9UKN8

UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8

Similarity: Belongs to the TFIIIC subunit 4 family

GTF3C4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TF3C4_HUMAN, Q9UKN8

Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA,

tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity

(HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment

of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A

box

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

Enzyme Number (IUBMB): EC 2.3.1.48¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	contributes to DNA binding	IC	17409385
GO:0004402	histone acetyltransferase activity	IEA	--
GO:0005515	protein binding	IPI	17409385
GO:0008047	enzyme activator activity	TAS	10523658

GTF3C4 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for GTF3C4:

Increased S DNA content

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for GTF3C4

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GTF3C4

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		SwitchGear 3'UTR luciferase reporter plasmid: GTF3C4 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GTF3C4 About

See pathways by source

SuperPath

Contained pathways About

RNA Polymerase III Transcription Initiation

RNA Polymerase III Transcription Initiation	0.80	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.77
RNA Polymerase III Transcription	0.80	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.74
RNA Polymerase III Abortive And Retractive Initiation	0.80	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.59

Assembly of RNA Polymerase-III Initiation Complex

Assembly of RNA Polymerase-III Initiation Complex

0.83

Transcription of tRNA

0.83

Transcription

Transcription

0.69

Generic Transcription Pathway

Gene Expression

0.47

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF3C4

	Transcription of tRNA
	Assembly of RNA Polymerase-III Initiation Complex

5/8 Reactome Pathways for GTF3C4 (see all 8)

	RNA Polymerase III Transcription Initiation
	Transcription
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	RNA Polymerase III Abortive And Retractive Initiation
	RNA Polymerase III Transcription Initiation From Type 1 Promoter

GTF3C4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GTF3C4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/691 Interacting proteins for GTF3C4 (Q9UKN8^{2, 3} ENSP00000361219⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 691)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GTF3C3	Q9Y5Q9²^,³, ENSP00000263956⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000263956
HIST2H3A	Q71DI3³, ENSP00000385479⁴	I2D: score=2 STRING: ENSP00000385479
GTF3C1	Q12789²^,³, ENSP00000348510⁴	MINT-7945693 MINT-6488791 I2D: score=2 STRING: ENSP00000348510
HIST2H3D	Q71DI3³, ENSP00000333277⁴	I2D: score=2 STRING: ENSP00000333277
HIST2H3C	Q71DI3³	I2D: score=2

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IC	17409385
GO:0006383	transcription from RNA polymerase III promoter	TAS	--
GO:0006384	transcription initiation from RNA polymerase III promoter	TAS	10523658
GO:0010467	gene expression	TAS	--
GO:0016573	histone acetylation	TAS	10523658

GTF3C4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GTF3C4 (TF3C4)

2 HMDB Compounds for GTF3C4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--

Search CenterWatch for drugs/clinical trials and news about GTF3C4 / TF3C4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GTF3C4 gene:

NM_012204.2

Unigene Cluster for GTF3C4:

General transcription factor IIIC, polypeptide 4, 90kDa

Hs.656646 [show with all ESTs]

Unigene Representative Sequence: NM_012204

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483873 ENST00000372146(uc010mzv.3 uc010mzw.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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		hsa-miR-4303 hsa-miR-505 hsa-miR-4307 hsa-miR-3155 hsa-miR-484 hsa-miR-141* hsa-miR-642b hsa-miR-3155b

		SwitchGear 3'UTR luciferase reporter plasmid: GTF3C4 3' UTR sequence

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Additional mRNA sequence:

AF086460.1 AF142328.1 AJ420451.1 AK024655.1 AK027509.1 AK126436.1 BC011619.2 BC022787.1

BC060821.1 BC094774.1 BC104755.1 BC112245.1

9 DOTS entries:

DT.101978566 DT.100707633 DT.97841365 DT.95259571 DT.97816401 DT.40111373 DT.91717779 DT.95225516

DT.97803439

24/202 AceView cDNA sequences (see all 202):

BQ004332 AK027509 BM992078 BM475335 Z44435 AA974491 AA587653 BC022787

BQ428209 H88620 AI078049 AA732790 BU632842 AW450958 AV726942 AW193285

BC011619 BM974523 AF086460 AI184450 BQ002223 BE019328 AI457895 AW043778

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GTF3C4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGTAACAGAA

About this image

See GTF3C4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GTF3C4

SOURCE GeneReport for Unigene cluster: Hs.656646

SABiosciences Custom PCR Arrays for GTF3C4

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C4 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Gtf3c4^{1 , 5}	general transcription factor IIIC, polypeptide 4^{1, 5}	87.6(n)¹ 93.76(a)¹	2 (19.38 cM)⁵ 269252¹ NM_172977.3¹ NP_766565.2¹ 28822305⁵
chicken (Gallus gallus)	Aves	GTF3C4¹	general transcription factor IIIC, polypeptide 4, 9 more	79.07(n) 86.48(a)	417167 XM_415450.3 XP_415450.3
African clawed frog (Xenopus laevis)	Amphibia	Xl.14576²	Xenopus laevis transcribed sequence with moderate similarity more	73.96(n)	BJ060086.1
zebrafish (Danio rerio)	Actinopterygii	Dr.10245²	Transcribed sequence with weak similarity to protein more	72.79(n)	57065365

ENSEMBL Gene Tree for GTF3C4 (if available)
TreeFam Gene Tree for GTF3C4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_047098⁴		--	--	see VAR_047098	2	H R	mis⁴		0	--	--	--	--
rs415410^1,2	C,F,O,A,H	--	135547839(+)	`CCAGGC/TGGCAG`	1	--	int¹		20		EA NA NS WA CSA	1418
rs72226285^1,2	C	--	135547891(+)	`GAACA-/TAAT TAATT`	1	--	int¹		0	--	--	--	--
rs59271809^1,2	C	--	135547893(+)	`AATTA-/ATTA TTGTT`	1	--	int¹		0	--	--	--	--
rs201376162^1,2	C	--	135547893(+)	`ACATAA/CTTAAT`	1	--	int¹		0	--	--	--	--
rs183795507^1,2		--	135547925(+)	`TCAGTA/CCATGA`	1	--	int¹		0	--	--	--	--
rs187918662^1,2		--	135548029(+)	`GAAGTA/CTTTAA`	1	--	int¹		0	--	--	--	--
rs191304255^1,2		--	135548101(+)	`AGAGGC/TAAGAA`	1	--	int¹		0	--	--	--	--
rs182682835^1,2	C	--	135548333(+)	`TTGGGA/GGGCCG`	1	--	int¹		0	--	--	--	--
rs80297152^1,2	C	--	135548551(+)	`GGCGAA/CAGAGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GTF3C4 (135545422 - 135570342 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for GTF3C4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF3C4

DNA2.0 Custom Variant and Variant Library Synthesis for GTF3C4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GTF3C4 for disorders About MalaCards

GTF3C4 for disorders About GeneDecksing

OMIM gene information: 604892 OMIM disorders: --

Genetic Association Database (GAD): GTF3C4
Human Genome Epidemiology (HuGE) Navigator: GTF3C4 (1 document)

Export disorders for GTF3C4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GTF3C4 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with GTF3C4)

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The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PubMed id 10523658)^{1, 2, 3} Hsieh Y.-J.... Roeder R.G. (1999)
Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PubMed id 17409385)^{1, 2} Dumay-Odelot H.... Teichmann M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)¹ Cloutier P.... Coulombe B. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)¹ Chu L....Tomasson M.H. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9329	HGNC: 4667	AceView: GTF3C4	Ensembl:ENSG00000125484	euGenes: HUgn9329
ECgene: GTF3C4	H-InvDB: GTF3C4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GTF3C4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GTF3C4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GTF3C4 gene:
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GTF3C4 Gene

General Transcription Factor IIIC, Polypeptide 4, 90kDa

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GTF3C4 Gene

General Transcription Factor IIIC, Polypeptide 4, 90kDa

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