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Aliases for GTF3C4 Gene

Aliases for GTF3C4 Gene

  • General Transcription Factor IIIC Subunit 4 2 3 5
  • General Transcription Factor IIIC, Polypeptide 4, 90kDa 2 3
  • Transcription Factor IIIC 90 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Delta 3 4
  • TFIIIC 90 KDa Subunit 3 4
  • TF3C-Delta 3 4
  • TFIIIC90 3 4
  • General Transcription Factor IIIC, Polypeptide 4 (90kD) 2
  • General Transcription Factor 3C 4 3
  • TFIIICDELTA 3
  • EC 2.3.1.48 4
  • TFIIIC290 3
  • TFIII90 3
  • KAT12 3

External Ids for GTF3C4 Gene

Previous GeneCards Identifiers for GTF3C4 Gene

  • GC09P126570
  • GC09P127102
  • GC09P128899
  • GC09P130821
  • GC09P132574
  • GC09P134535
  • GC09P135545
  • GC09P105039

Summaries for GTF3C4 Gene

GeneCards Summary for GTF3C4 Gene

GTF3C4 (General Transcription Factor IIIC Subunit 4) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot for GTF3C4 Gene

  • Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Gene Wiki entry for GTF3C4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C4 Gene

Genomics for GTF3C4 Gene

Regulatory Elements for GTF3C4 Gene

Enhancers for GTF3C4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF3C4 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF3C4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF3C4 Gene

Chromosome:
9
Start:
132,670,035 bp from pter
End:
132,694,955 bp from pter
Size:
24,921 bases
Orientation:
Plus strand

Genomic View for GTF3C4 Gene

Genes around GTF3C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C4 Gene

Proteins for GTF3C4 Gene

  • Protein details for GTF3C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKN8-TF3C4_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 4
    Protein Accession:
    Q9UKN8
    Secondary Accessions:
    • Q5VZJ7

    Protein attributes for GTF3C4 Gene

    Size:
    822 amino acids
    Molecular mass:
    91982 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
    SequenceCaution:
    • Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for GTF3C4 Gene

Proteomics data for GTF3C4 Gene at MOPED

Post-translational modifications for GTF3C4 Gene

  • Ubiquitination at Lys 123, Lys 225, Lys 364, Lys 467, and Lys 807
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF3C4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF3C4 Gene

Domains & Families for GTF3C4 Gene

Protein Domains for GTF3C4 Gene

Suggested Antigen Peptide Sequences for GTF3C4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKN8

UniProtKB/Swiss-Prot:

TF3C4_HUMAN :
  • Belongs to the TFIIIC subunit 4 family.
Family:
  • Belongs to the TFIIIC subunit 4 family.
genes like me logo Genes that share domains with GTF3C4: view

Function for GTF3C4 Gene

Molecular function for GTF3C4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Enzyme Numbers (IUBMB) for GTF3C4 Gene

Gene Ontology (GO) - Molecular Function for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17409385
genes like me logo Genes that share ontologies with GTF3C4: view
genes like me logo Genes that share phenotypes with GTF3C4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GTF3C4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C4 Gene

Localization for GTF3C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C4 Gene COMPARTMENTS Subcellular localization image for GTF3C4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GTF3C4 Gene

Pathways & Interactions for GTF3C4 Gene

genes like me logo Genes that share pathways with GTF3C4: view

Gene Ontology (GO) - Biological Process for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter IC,TAS 17409385
GO:0010467 gene expression TAS --
GO:0016573 histone acetylation TAS 10523658
genes like me logo Genes that share ontologies with GTF3C4: view

No data available for SIGNOR curated interactions for GTF3C4 Gene

Drugs & Compounds for GTF3C4 Gene

(1) Drugs for GTF3C4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for GTF3C4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with GTF3C4: view

Transcripts for GTF3C4 Gene

mRNA/cDNA for GTF3C4 Gene

Unigene Clusters for GTF3C4 Gene

General transcription factor IIIC, polypeptide 4, 90kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C4 Gene

No ASD Table

Relevant External Links for GTF3C4 Gene

GeneLoc Exon Structure for
GTF3C4
ECgene alternative splicing isoforms for
GTF3C4

Expression for GTF3C4 Gene

mRNA expression in normal human tissues for GTF3C4 Gene

Protein differential expression in normal tissues from HIPED for GTF3C4 Gene

This gene is overexpressed in Cerebrospinal fluid (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C4 Gene



SOURCE GeneReport for Unigene cluster for GTF3C4 Gene Hs.656646

genes like me logo Genes that share expression patterns with GTF3C4: view

Protein tissue co-expression partners for GTF3C4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C4 Gene

Orthologs for GTF3C4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF3C4 35
  • 88.56 (n)
  • 93.85 (a)
GTF3C4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C4 35
  • 91.65 (n)
  • 95.74 (a)
GTF3C4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c4 35
  • 87.52 (n)
  • 93.51 (a)
Gtf3c4 16
Gtf3c4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF3C4 35
  • 98.79 (n)
  • 98.84 (a)
GTF3C4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c4 35
  • 87.39 (n)
  • 93.51 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF3C4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C4 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C4 35
  • 79.71 (n)
  • 87.6 (a)
GTF3C4 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c4 35
  • 68.11 (n)
  • 70.51 (a)
Str.14605 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14576 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10245 35
gtf3c4 35
  • 60.82 (n)
  • 59.44 (a)
gtf3c4 36
  • 60 (a)
OneToOne
Species with no ortholog for GTF3C4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C4 Gene

ENSEMBL:
Gene Tree for GTF3C4 (if available)
TreeFam:
Gene Tree for GTF3C4 (if available)

Paralogs for GTF3C4 Gene

No data available for Paralogs for GTF3C4 Gene

Variants for GTF3C4 Gene

Sequence variations from dbSNP and Humsavar for GTF3C4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_047098 -
rs708616 -- 132,689,559(-) AATTT(C/T)AGTCT downstream-variant-500B, utr-variant-3-prime
rs755728 -- 132,673,984(+) TTGTG(C/T)ACCGA intron-variant
rs755729 -- 132,673,854(+) TGGAC(A/C)GTATA intron-variant
rs787240 -- 132,684,752(-) aactg(A/G)aggaa intron-variant

Variation tolerance for GTF3C4 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GTF3C4 Gene

Disorders for GTF3C4 Gene

Relevant External Links for GTF3C4

Genetic Association Database (GAD)
GTF3C4
Human Genome Epidemiology (HuGE) Navigator
GTF3C4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C4

No disorders were found for GTF3C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C4 Gene

Publications for GTF3C4 Gene

  1. The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PMID: 10523658) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for GTF3C4 Gene

Sources for GTF3C4 Gene

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