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Aliases for GTF3C4 Gene

Aliases for GTF3C4 Gene

  • General Transcription Factor IIIC Subunit 4 2 3 5
  • General Transcription Factor IIIC, Polypeptide 4, 90kDa 2 3
  • Transcription Factor IIIC 90 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Delta 3 4
  • TFIIIC 90 KDa Subunit 3 4
  • TF3C-Delta 3 4
  • TFIIIC90 3 4
  • General Transcription Factor IIIC, Polypeptide 4 (90kD) 2
  • General Transcription Factor 3C Polypeptide 4 3
  • General Transcription Factor 3C 4 3
  • TFIIICDELTA 3
  • EC 2.3.1.48 4
  • TFIIIC290 3
  • TFIII90 3
  • KAT12 3

External Ids for GTF3C4 Gene

Previous GeneCards Identifiers for GTF3C4 Gene

  • GC09P126570
  • GC09P127102
  • GC09P128899
  • GC09P130821
  • GC09P132574
  • GC09P134535
  • GC09P135545
  • GC09P105039

Summaries for GTF3C4 Gene

GeneCards Summary for GTF3C4 Gene

GTF3C4 (General Transcription Factor IIIC Subunit 4) is a Protein Coding gene. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot for GTF3C4 Gene

  • Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Gene Wiki entry for GTF3C4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C4 Gene

Genomics for GTF3C4 Gene

Regulatory Elements for GTF3C4 Gene

Enhancers for GTF3C4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F133112 0.7 FANTOM5 ENCODE 43.6 +459.0 458987 33.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 RALGDS SETX GTF3C4 TSC1 LOC100130548 REXO4 TTF1 SURF6 GBGT1 LINC00094
GH09F132240 0.2 ENCODE 12.5 -428.7 -428665 2.7 HDGF GLI4 ZNF2 ZNF121 GLIS2 ZNF202 SP3 YY2 SMARCA4 ZNF585B TSC1 GTF3C4 SETX NTNG2 GC09M132284
GH09F133333 0.2 ENCODE 12 +665.2 665249 4.2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SURF6 SURF1 WDR5 GTF3C4 LOC100130548 TSC1 SURF4 REXO4 RXRA TTF1
GH09F132994 0.8 Ensembl ENCODE 11.3 +324.8 324766 1.2 HDGF HDAC1 ATF1 CBX3 TBL1XR1 GATA2 SCRT2 FOS CREM ZBTB2 RNU7-21P RPL39P24 GTF3C4 TSC1 SETX GTF3C5 OBP2B GC09P133045 GC09P133069 GC09P133080
GH09F133022 0.8 Ensembl ENCODE 11.3 +352.9 352859 1.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CBX5 SETX RNU7-21P RPL39P24 GTF3C4 TSC1 EEF1A1P5 GC09P133063 GC09P133071 GC09P133075 GC09P133077
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GTF3C4 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001475608 265 3001 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for GTF3C4 Gene

Chromosome:
9
Start:
132,670,035 bp from pter
End:
132,694,955 bp from pter
Size:
24,921 bases
Orientation:
Plus strand

Genomic View for GTF3C4 Gene

Genes around GTF3C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C4 Gene

Proteins for GTF3C4 Gene

  • Protein details for GTF3C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKN8-TF3C4_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 4
    Protein Accession:
    Q9UKN8
    Secondary Accessions:
    • Q5VZJ7

    Protein attributes for GTF3C4 Gene

    Size:
    822 amino acids
    Molecular mass:
    91982 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
    SequenceCaution:
    • Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for GTF3C4 Gene

Post-translational modifications for GTF3C4 Gene

  • Ubiquitination at Lys 123, Lys 225, Lys 364, Lys 467, and Lys 807
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF3C4 Gene

No data available for DME Specific Peptides for GTF3C4 Gene

Domains & Families for GTF3C4 Gene

Protein Domains for GTF3C4 Gene

Suggested Antigen Peptide Sequences for GTF3C4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKN8

UniProtKB/Swiss-Prot:

TF3C4_HUMAN :
  • Belongs to the TFIIIC subunit 4 family.
Family:
  • Belongs to the TFIIIC subunit 4 family.
genes like me logo Genes that share domains with GTF3C4: view

Function for GTF3C4 Gene

Molecular function for GTF3C4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Enzyme Numbers (IUBMB) for GTF3C4 Gene

Gene Ontology (GO) - Molecular Function for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IEA,IC 17409385
GO:0004402 histone acetyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 17409385
GO:0008047 enzyme activator activity TAS 10523658
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GTF3C4: view
genes like me logo Genes that share phenotypes with GTF3C4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GTF3C4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C4 Gene

Localization for GTF3C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C4 Gene COMPARTMENTS Subcellular localization image for GTF3C4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C4: view

Pathways & Interactions for GTF3C4 Gene

genes like me logo Genes that share pathways with GTF3C4: view

Gene Ontology (GO) - Biological Process for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006383 transcription from RNA polymerase III promoter IC 17409385
GO:0006384 transcription initiation from RNA polymerase III promoter TAS 10523658
GO:0016573 histone acetylation IEA --
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter IC 17409385
genes like me logo Genes that share ontologies with GTF3C4: view

No data available for SIGNOR curated interactions for GTF3C4 Gene

Drugs & Compounds for GTF3C4 Gene

(1) Drugs for GTF3C4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for GTF3C4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with GTF3C4: view

Transcripts for GTF3C4 Gene

mRNA/cDNA for GTF3C4 Gene

Unigene Clusters for GTF3C4 Gene

General transcription factor IIIC, polypeptide 4, 90kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C4 Gene

No ASD Table

Relevant External Links for GTF3C4 Gene

GeneLoc Exon Structure for
GTF3C4
ECgene alternative splicing isoforms for
GTF3C4

Expression for GTF3C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF3C4 Gene

Protein differential expression in normal tissues from HIPED for GTF3C4 Gene

This gene is overexpressed in Cerebrospinal fluid (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C4 Gene



Protein tissue co-expression partners for GTF3C4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF3C4 Gene:

GTF3C4

SOURCE GeneReport for Unigene cluster for GTF3C4 Gene:

Hs.656646
genes like me logo Genes that share expression patterns with GTF3C4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C4 Gene

Orthologs for GTF3C4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C4 34 35
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia GTF3C4 34 35
  • 91.65 (n)
cow
(Bos Taurus)
Mammalia GTF3C4 34 35
  • 88.56 (n)
mouse
(Mus musculus)
Mammalia Gtf3c4 34 16 35
  • 87.52 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c4 34
  • 87.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C4 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF3C4 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C4 34 35
  • 79.71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c4 34
  • 68.11 (n)
Str.14605 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14576 34
zebrafish
(Danio rerio)
Actinopterygii gtf3c4 34 35
  • 60.82 (n)
Dr.10245 34
Species where no ortholog for GTF3C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C4 Gene

ENSEMBL:
Gene Tree for GTF3C4 (if available)
TreeFam:
Gene Tree for GTF3C4 (if available)

Paralogs for GTF3C4 Gene

No data available for Paralogs for GTF3C4 Gene

Variants for GTF3C4 Gene

Sequence variations from dbSNP and Humsavar for GTF3C4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1045737 -- 132,694,354(+) GGATG(A/T)AATGT nc-transcript-variant, utr-variant-3-prime
rs1045740 -- 132,694,532(+) TATCT(A/G)ATATT nc-transcript-variant, utr-variant-3-prime
rs10491904 -- 132,675,386(-) TTAAA(C/T)GAGGT intron-variant
rs10536880 -- 132,690,441(+) GCCTC(-/AAA)AAAAA nc-transcript-variant, cds-indel
rs10576769 -- 132,693,651(+) TCATT(-/AA)AAAAA nc-transcript-variant, utr-variant-3-prime

Variation tolerance for GTF3C4 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3C4 Gene

Disorders for GTF3C4 Gene

Relevant External Links for GTF3C4

Genetic Association Database (GAD)
GTF3C4
Human Genome Epidemiology (HuGE) Navigator
GTF3C4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C4

No disorders were found for GTF3C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C4 Gene

Publications for GTF3C4 Gene

  1. The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PMID: 10523658) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4 64
  2. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. (PMID: 26511642) Wang M. … Yi J. (Protein Cell 2016) 3 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for GTF3C4 Gene

Sources for GTF3C4 Gene

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