GTF3C4 Gene
protein-coding GIFtS: 50
GCID: GC09P135545
|
|
general transcription factor IIIC, polypeptide 4, 90kDa(Previous names: general transcription factor IIIC, polypeptide 4 (90kD)...)
| |
Aliases
for GTF3C4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| General Transcription Factor IIIC, Polypeptide 4, 90kDa1 2 | | General Transcription Factor IIIC, Polypeptide 4 (90kD)1 | | TFIIIC901 2 3 | | TFIII902 | | KAT121 2 | | TFIIIC2902 | | Transcription Factor IIIC 90 KDa Subunit2 3 | | TFIIICDELTA2 | | Transcription Factor IIIC Subunit Delta2 3 | | General Transcription Factor 3C 42 | | TF3C-Delta1 | | General Transcription Factor 3C Polypeptide 42 | | TFIIIC 90 KDa Subunit2 3 | | EC 2.3.1.483 |
Export aliases for GTF3C4 gene to outside databasesPrevious GC identifers: GC09P126570 GC09P127102 GC09P128899 GC09P130821 GC09P132574 GC09P134535 GC09P105039 |
Summaries
for GTF3C4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA,tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity(HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitmentof TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the Abox
Gene Wiki entry for GTF3C4
|
Genomic Views
for GTF3C4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GTF3C4 gene promoter:
Nkx2-2 YY1 C/EBPalpha E47 E2F E2F-1 POU2F1 POU2F1a Hand1 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GTF3C4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF3C4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.13 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34.3GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P135545: view genomic region
(about GC identifiers)
Start:
|
135,545,422 bp from pter |
End:
|
135,570,342 bp from pter |
Size:
|
24,921 bases |
Orientation:
|
plus strand |
|
Proteins
for GTF3C4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8 (See
protein sequence)Recommended Name: General transcription factor 3C polypeptide 4 Size: 822 amino acids; 91982 Da
Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 andGTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F
Subcellular location: Nucleus
Sequence caution: Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q5VZJ7Explore the universe of human proteins at neXtProt for GTF3C4: NX_Q9UKN8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKN8
GTF3C4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036336.2
ENSEMBL proteins: ENSP00000361219 ENSP00000431378 Reactome Protein details: Q9UKN8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GTF3C4 for ontologies About GeneDecksing
GTF3C4 Antibody Products:
Assay Products for GTF3C4: |
Protein
Domains /
Families
for GTF3C4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GTF3C4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKN8ProtoNet protein and cluster: Q9UKN8 UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8Similarity: Belongs to the TFIIIC subunit 4 family |
Function
for GTF3C4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TF3C4_HUMAN, Q9UKN8Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA,tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity(HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitmentof TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the AboxCatalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]Enzyme Number (IUBMB): EC 2.3.1.481
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
GTF3C4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GTF3C4:
|
Pathways & Interactions
for GTF3C4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase III Transcription Initiation | | | 2 | Assembly of RNA Polymerase-III Initiation Complex | | | 3 | Transcription | | | 4 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF3C4
5/8 
Reactome Pathways for GTF3C4 (see all 8)
GTF3C4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF3C4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/663 Interacting proteins for GTF3C4 (Q9UKN82, 3 ENSP000003612194) via UniProtKB, MINT, STRING, and/or I2D (see all 663)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
GTF3C4 for ontologies About GeneDecksing
|
Drugs & Compounds
for GTF3C4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GTF3C4
2 HMDB Compounds for GTF3C4 About this table
Search CenterWatch for drugs/clinical trials and news about GTF3C4 / TF3C4
|
Transcripts
for GTF3C4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GTF3C4 gene: NM_012204.2 Unigene Cluster for GTF3C4: General transcription factor IIIC, polypeptide 4, 90kDa Hs.656646 [show with all ESTs]Unigene Representative Sequence: NM_0122042 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372146(uc010mzv.3 uc010mzw.3) ENST00000483873
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GTF3C4 (NM_012204) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GTF3C4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C4 |
Additional cDNA sequence: AF086460.1 AF142328.1 AJ420451.1 AK024655.1 AK027509.1 AK126436.1 BC011619.2 BC022787.1 BC060821.1 BC094774.1 BC104755.1 BC112245.1 9 DOTS entries: DT.101978566 DT.100707633 DT.97841365 DT.95259571 DT.97816401 DT.40111373 DT.91717779 DT.95225516 DT.97803439 24/202 AceView cDNA sequences (see all 202): AA587653 AA351581 AI184450 AF086460 AW297811 BQ233577 AW043778 AW193285 AA429809 AI457895 BE019328 AA732790 BI870766 AV726942 BQ002223 AA974491 AA446146 Z44435 BM992078 BM475335 H88620 BU178871 BM974523 AA627475
GeneLoc Exon Structure
|
Expression
for GTF3C4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GTF3C4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAACAGAA
About this image
See GTF3C4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GTF3C4
SOURCE GeneReport for Unigene cluster: Hs.656646
SABiosciences Custom PCR Arrays for GTF3C4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTF3C4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GTF3C4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF3C4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF3C4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C4 |
Orthologs
for GTF3C4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GTF3C4 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gtf3c41 , 5 |
general transcription factor IIIC, polypeptide 41, 5 |
87.6(n)1
93.76(a)1 |
|
2 (19.38 cM)5
2692521 NM_172977.31 NP_766565.21
288223055 |
chicken
(Gallus gallus) |
Aves |
GTF3C41 |
general transcription factor IIIC, polypeptide 4, 9 more |
79.07(n)
86.48(a) |
|
417167 XM_415450.3 XP_415450.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.145762 |
Xenopus laevis transcribed sequence with moderate similarity more |
73.96(n) |
|
BJ060086.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.102452 |
Transcribed sequence with weak similarity to protein more |
72.79(n) |
|
57065365 |
ENSEMBL Gene Tree for GTF3C4 (if available)
TreeFam Gene Tree for GTF3C4 (if available) |
Paralogs
for GTF3C4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GTF3C4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GTF3C4 (135545422 - 135570342 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GTF3C4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF3C4 |
|
Disorders
/ Diseases
for GTF3C4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GTF3C4 for disorders About GeneDecksing
OMIM gene information: 604892
OMIM disorders: --
1  disease for GTF3C4: About MalaCardsimmunodeficiency
Human Genome Epidemiology (HuGE) Navigator: GTF3C4 (1 document)
Export disorders for GTF3C4 gene to outside databases
|
Publications
for GTF3C4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GTF3C4 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with GTF3C4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PubMed id 10523658)1, 2, 3 Hsieh Y.-J.... Roeder R.G. (1999)
- Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PubMed id 17409385)1, 2 Dumay-Odelot H.... Teichmann M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for GTF3C4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GTF3C4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GTF3C4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GTF3C4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GTF3C4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GTF3C4 gene:
Search GeneIP for patents involving GTF3C4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GTF3C4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C4 |
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