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Aliases for GTF3C4 Gene

Aliases for GTF3C4 Gene

  • General Transcription Factor IIIC, Polypeptide 4, 90kDa 2 3
  • Transcription Factor IIIC 90 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Delta 3 4
  • TFIIIC 90 KDa Subunit 3 4
  • TF3C-Delta 3 4
  • TFIIIC90 3 4
  • General Transcription Factor IIIC, Polypeptide 4 (90kD) 2
  • General Transcription Factor 3C Polypeptide 4 3
  • General Transcription Factor 3C 4 3
  • TFIIICDELTA 3
  • EC 2.3.1.48 4
  • TFIIIC290 3
  • TFIII90 3
  • KAT12 3

External Ids for GTF3C4 Gene

Summaries for GTF3C4 Gene

GeneCards Summary for GTF3C4 Gene

GTF3C4 (General Transcription Factor IIIC, Polypeptide 4, 90kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot for GTF3C4 Gene

  • Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box

Gene Wiki entry for GTF3C4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C4 Gene

Genomics for GTF3C4 Gene

Genomic Location for GTF3C4 Gene

Start:
132,670,035 bp from pter
End:
132,694,955 bp from pter
Size:
24,921 bases
Orientation:
Plus strand

Genomic View for GTF3C4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF3C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C4 Gene

Regulatory Elements for GTF3C4 Gene

Proteins for GTF3C4 Gene

  • Protein details for GTF3C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKN8-TF3C4_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 4
    Protein Accession:
    Q9UKN8
    Secondary Accessions:
    • Q5VZJ7

    Protein attributes for GTF3C4 Gene

    Size:
    822 amino acids
    Molecular mass:
    91982 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
    SequenceCaution:
    • Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for GTF3C4 Gene

Proteomics data for GTF3C4 Gene at MOPED

Post-translational modifications for GTF3C4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123, Lys225, Lys364, Lys467, and Lys807

Other Protein References for GTF3C4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF3C4 Gene

Domains for GTF3C4 Gene

Gene Families for GTF3C4 Gene

HGNC:
  • GTF :General transcription factors
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases

Protein Domains for GTF3C4 Gene

UniProtKB/Swiss-Prot:

TF3C4_HUMAN
Family:
  • Belongs to the TFIIIC subunit 4 family.:
    • Q9UKN8
genes like me logo Genes that share domains with GTF3C4: view

Function for GTF3C4 Gene

Molecular function for GTF3C4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box

Enzyme Numbers (IUBMB) for GTF3C4 Gene

Gene Ontology (GO) - Molecular Function for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IC 17409385
GO:0004402 histone acetyltransferase activity IEA --
GO:0005515 protein binding IPI 17409385
GO:0008047 enzyme activator activity TAS 10523658
genes like me logo Genes that share ontologies with GTF3C4: view

Phenotypes for GTF3C4 Gene

genes like me logo Genes that share phenotypes with GTF3C4: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GTF3C4 Gene

Localization for GTF3C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C4 Gene COMPARTMENTS Subcellular localization image for GTF3C4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C4: view

Pathways for GTF3C4 Gene

genes like me logo Genes that share pathways with GTF3C4: view

Gene Ontology (GO) - Biological Process for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006384 transcription initiation from RNA polymerase III promoter TAS 10523658
GO:0010467 gene expression TAS --
GO:0016573 histone acetylation TAS 10523658
genes like me logo Genes that share ontologies with GTF3C4: view

Compounds for GTF3C4 Gene

(2) HMDB Compounds for GTF3C4 Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
genes like me logo Genes that share compounds with GTF3C4: view

Transcripts for GTF3C4 Gene

mRNA/cDNA for GTF3C4 Gene

Unigene Clusters for GTF3C4 Gene

General transcription factor IIIC, polypeptide 4, 90kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C4 Gene

No ASD Table

Relevant External Links for GTF3C4 Gene

GeneLoc Exon Structure for
GTF3C4
ECgene alternative splicing isoforms for
GTF3C4

Expression for GTF3C4 Gene

mRNA expression in normal human tissues for GTF3C4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C4 Gene

SOURCE GeneReport for Unigene cluster for GTF3C4 Gene Hs.656646

genes like me logo Genes that share expressions with GTF3C4: view

Orthologs for GTF3C4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C4 36
  • 98.79 (n)
  • 98.84 (a)
GTF3C4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTF3C4 36
  • 88.56 (n)
  • 93.85 (a)
GTF3C4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C4 36
  • 91.65 (n)
  • 95.74 (a)
GTF3C4 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c4 36
  • 87.52 (n)
  • 93.51 (a)
Gtf3c4 16
Gtf3c4 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF3C4 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C4 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c4 36
  • 87.39 (n)
  • 93.51 (a)
chicken
(Gallus gallus)
Aves GTF3C4 36
  • 79.71 (n)
  • 87.6 (a)
GTF3C4 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14576 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c4 36
  • 68.11 (n)
  • 70.51 (a)
Str.14605 36
zebrafish
(Danio rerio)
Actinopterygii Dr.10245 36
gtf3c4 36
  • 60.82 (n)
  • 59.44 (a)
gtf3c4 37
  • 60 (a)
OneToOne
Species with no ortholog for GTF3C4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C4 Gene

ENSEMBL:
Gene Tree for GTF3C4 (if available)
TreeFam:
Gene Tree for GTF3C4 (if available)

Paralogs for GTF3C4 Gene

No data available for Paralogs for GTF3C4 Gene

Variants for GTF3C4 Gene

Sequence variations from dbSNP and Humsavar for GTF3C4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs96153 -- 132,674,706(+) TTTGC(A/G)TACTT intron-variant
rs365297 -- 132,685,458(-) AATTA(G/T)GAAAC intron-variant
rs371169 -- 132,679,179(+) GAAGA(A/G)GCAGC synonymous-codon, reference
rs371222 -- 132,690,283(-) TATTT(G/T)TAGTA downstream-variant-500B
rs377090 -- 132,673,352(+) ATAGC(C/T)CTCTT intron-variant

Relevant External Links for GTF3C4 Gene

HapMap Linkage Disequilibrium report
GTF3C4

No data available for Structural Variations from Database of Genomic Variants (DGV) for GTF3C4 Gene

Disorders for GTF3C4 Gene

Relevant External Links for GTF3C4

Genetic Association Database (GAD)
GTF3C4
Human Genome Epidemiology (HuGE) Navigator
GTF3C4
genes like me logo Genes that share disorders with GTF3C4: view

No data available for UniProtKB/Swiss-Prot for GTF3C4 Gene

Publications for GTF3C4 Gene

  1. The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PMID: 10523658) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 3 4
  4. In vitro nuclear interactome of the HIV-1 Tat protein. (PMID: 19454010) Gautier V.W. … Hall W.W. (Retrovirology 2009) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for GTF3C4 Gene

Sources for GTF3C4 Gene

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