Aliases for GTF3C4 Gene
Aliases for GTF3C4 Gene
- General Transcription Factor IIIC Subunit 4 2 3 5
- General Transcription Factor IIIC, Polypeptide 4, 90kDa 2 3
- Transcription Factor IIIC 90 KDa Subunit 3 4
- Transcription Factor IIIC Subunit Delta 3 4
- TFIIIC 90 KDa Subunit 3 4
- TF3C-Delta 3 4
- TFIIIC90 3 4
- General Transcription Factor IIIC, Polypeptide 4 (90kD) 2
External Ids for GTF3C4 Gene
- HGNC: 4667
- Entrez Gene: 9329
- Ensembl: ENSG00000125484
- OMIM: 604892
- UniProtKB: Q9UKN8
Previous GeneCards Identifiers for GTF3C4 Gene
- GC09P126570
- GC09P127102
- GC09P128899
- GC09P130821
- GC09P132574
- GC09P134535
- GC09P135545
- GC09P105039
Summaries for GTF3C4 Gene
GeneCards Summary for GTF3C4 Gene
GTF3C4 (General Transcription Factor IIIC Subunit 4) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.
UniProtKB/Swiss-Prot for GTF3C4 Gene
-
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Additional gene information for GTF3C4 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C4 Gene
Genomics for GTF3C4 Gene
GeneHancer (GH) Regulatory Elements for GTF3C4 Gene
Regulatory Element Products
Genomic Locations for GTF3C4 Gene
- chr9:132,670,035-132,694,955
- (GRCh38/hg38)
- Size:
- 24,921 bases
- Orientation:
- Plus strand
- chr9:135,545,422-135,570,342
- (GRCh37/hg19)
Genomic View for GTF3C4 Gene
- Cytogenetic band:
-
- 9q34.13 by Ensembl
- 9q34.13 by Entrez Gene
- 9q34.13 by HGNC


RefSeq DNA sequence for GTF3C4 Gene
Proteins for GTF3C4 Gene
-
Protein details for GTF3C4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKN8-TF3C4_HUMAN
- Recommended name:
- General transcription factor 3C polypeptide 4
- Protein Accession:
- Q9UKN8
- Q5VZJ7
Protein attributes for GTF3C4 Gene
- Size:
- 822 amino acids
- Molecular mass:
- 91982 Da
- Quaternary structure:
-
- Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
- SequenceCaution:
-
- Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for GTF3C4 Gene
Post-translational modifications for GTF3C4 Gene
- Ubiquitination at isoforms=123, posLast=225225, isoforms=364, isoforms=467, and posLast=807807
Other Protein References for GTF3C4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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-
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-
Abcam proteins for GTF3C4
Assay Products
No data available for DME Specific Peptides for GTF3C4 Gene
Domains & Families for GTF3C4 Gene
Gene Families for GTF3C4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GTF3C4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GTF3C4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UKN8- Family:
-
- Belongs to the TFIIIC subunit 4 family.
Function for GTF3C4 Gene
Molecular function for GTF3C4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Enzyme Numbers (IUBMB) for GTF3C4 Gene
Phenotypes From GWAS Catalog for GTF3C4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | contributes_to DNA binding | IC | 17409385 |
GO:0004402 | histone acetyltransferase activity | IEA,TAS | -- |
GO:0005515 | protein binding | IPI | 17409385 |
GO:0008047 | enzyme activator activity | TAS | 10523658 |
GO:0016740 | transferase activity | IEA | -- |
Phenotypes for GTF3C4 Gene
- GenomeRNAi human phenotypes for GTF3C4:
-
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
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-
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miRNA for GTF3C4 Gene
- miRTarBase miRNAs that target GTF3C4
-
- hsa-mir-30a-5p (MIRT028677)
- hsa-mir-16-5p (MIRT031966)
- hsa-let-7b-5p (MIRT032467)
- hsa-mir-615-3p (MIRT039620)
- hsa-mir-331-3p (MIRT043336)
- hsa-mir-320a (MIRT044408)
- hsa-let-7e-3p (MIRT227803)
- hsa-mir-571 (MIRT227804)
- hsa-mir-3173-3p (MIRT227806)
- hsa-mir-4259 (MIRT227807)
- hsa-mir-4428 (MIRT227809)
- hsa-mir-4477b (MIRT227810)
- hsa-mir-6891-5p (MIRT227812)
- hsa-mir-875-3p (MIRT240700)
- hsa-mir-489-3p (MIRT563542)
- hsa-let-7d-3p (MIRT563543)
- hsa-mir-3913-3p (MIRT563544)
- hsa-mir-873-5p (MIRT563545)
- hsa-mir-1299 (MIRT684312)
- hsa-mir-642a-5p (MIRT684313)
- hsa-mir-4487 (MIRT684314)
- hsa-mir-558 (MIRT684315)
- hsa-mir-3160-3p (MIRT684316)
- hsa-mir-6846-3p (MIRT684317)
- hsa-mir-494-3p (MIRT684318)
- hsa-mir-6128 (MIRT684319)
- hsa-mir-6751-3p (MIRT684320)
- hsa-mir-1199-5p (MIRT684321)
- hsa-mir-1251-5p (MIRT684322)
- hsa-mir-3925-3p (MIRT684323)
- hsa-mir-766-3p (MIRT684324)
- hsa-mir-1304-3p (MIRT684325)
- hsa-mir-6769b-3p (MIRT684326)
- hsa-mir-4723-3p (MIRT684327)
- hsa-mir-3183 (MIRT684328)
- hsa-mir-4308 (MIRT684329)
- hsa-mir-2276-5p (MIRT684330)
- hsa-mir-6892-3p (MIRT684331)
- hsa-mir-1324 (MIRT684332)
- hsa-mir-1182 (MIRT684333)
- hsa-mir-3184-3p (MIRT684334)
- hsa-mir-3646 (MIRT684335)
- hsa-mir-130a-5p (MIRT762494)
- hsa-mir-186-3p (MIRT763192)
- hsa-mir-188-5p (MIRT763223)
- hsa-mir-23a-3p (MIRT764011)
- hsa-mir-23b-3p (MIRT764029)
- hsa-mir-23c (MIRT764047)
- hsa-mir-28-5p (MIRT764339)
- hsa-mir-3139 (MIRT764974)
- hsa-mir-3606-3p (MIRT765849)
- hsa-mir-4282 (MIRT768367)
- hsa-mir-4633-3p (MIRT770495)
- hsa-mir-513a-3p (MIRT773384)
- hsa-mir-513c-3p (MIRT773411)
- hsa-mir-610 (MIRT775778)
- hsa-mir-6500-5p (MIRT776489)
- hsa-mir-6715a-3p (MIRT777672)
- hsa-mir-6715b-3p (MIRT777683)
- hsa-mir-6866-3p (MIRT780652)
- hsa-mir-708-5p (MIRT781310)
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C4 Gene
Localization for GTF3C4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GTF3C4 Gene
- Nucleus.
- Nucleus (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000127 | transcription factor TFIIIC complex | IDA | 17409385 |
GO:0005634 | nucleus | IDA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005739 | mitochondrion | IDA | -- |
Pathways & Interactions for GTF3C4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase III Transcription Initiation | ||
2 | Transcription of tRNA | ||
3 | Gene Expression |
.48
|
|
4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
Pathways by source for GTF3C4 Gene
2 Qiagen pathways for GTF3C4 Gene
Interacting Proteins for GTF3C4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IC | 17409385 |
GO:0006383 | transcription by RNA polymerase III | IC | 17409385 |
GO:0006384 | transcription initiation from RNA polymerase III promoter | TAS | 10523658 |
GO:0016573 | histone acetylation | IEA | -- |
GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter | IC | 17409385 |
No data available for SIGNOR curated interactions for GTF3C4 Gene
Drugs & Compounds for GTF3C4 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Coenzyme A | Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
acetyl-coa |
|
72-89-9 |
|
Transcripts for GTF3C4 Gene
mRNA/cDNA for GTF3C4 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (202) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GTF3C4 Gene
CRISPR Products
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-
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GTF3C4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C4 Gene
NURSA nuclear receptor signaling pathways regulating expression of GTF3C4 Gene:
GTF3C4SOURCE GeneReport for Unigene cluster for GTF3C4 Gene:
Hs.656646Evidence on tissue expression from TISSUES for GTF3C4 Gene
- Nervous system(4.3)
Primer Products
-
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OriGene qPCR primer pairs for GTF3C4
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C4 Gene
Orthologs for GTF3C4 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GTF3C4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GTF3C4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GTF3C4 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Gtf3c4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Gtf3c4 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | GTF3C4 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | GTF3C4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GTF3C4 33 34 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | gtf3c4 33 |
|
||
Str.14605 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14576 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | gtf3c4 33 34 |
|
||
Dr.10245 33 |
|
- Species where no ortholog for GTF3C4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GTF3C4 Gene
No data available for Paralogs for GTF3C4 Gene
Variants for GTF3C4 Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000216176 | -- | 132,686,131(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
rs1000751178 | -- | 132,685,937(+) | C/G | genic_downstream_transcript_variant, intron_variant | |
rs1000778802 | -- | 132,695,087(+) | A/C | downstream_transcript_variant | |
rs1000831683 | -- | 132,668,422(+) | C/A | upstream_transcript_variant | |
rs1000938799 | -- | 132,676,112(+) | GATGGTCTCGAT/GAT | intron_variant |
Additional Variant Information for GTF3C4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GTF3C4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3C4 Gene
Disorders for GTF3C4 Gene
Additional Disease Information for GTF3C4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GTF3C4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C4 Gene
Publications for GTF3C4 Gene
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PMID: 10523658) Hsieh YJ … Roeder RG (Molecular and cellular biology 1999) 2 3 4 58
- Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H … Teichmann M (The Journal of biological chemistry 2007) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
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Sources for GTF3C4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
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