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Aliases for GTF3C3 Gene

Aliases for GTF3C3 Gene

  • General Transcription Factor IIIC Subunit 3 2 3 5
  • General Transcription Factor IIIC, Polypeptide 3, 102kDa 2 3
  • Transcription Factor IIIC Subunit Gamma 3 4
  • TFIIIC 102 KDa Subunit 3 4
  • TF3C-Gamma 3 4
  • TFIIIC102 3 4
  • General Transcription Factor IIIC, Polypeptide 3 (102kD) 2
  • Transcription Factor IIIC 102 KDa Subunit 4
  • TFIIICgamma 3
  • TFiiiC2-102 3

External Ids for GTF3C3 Gene

Previous GeneCards Identifiers for GTF3C3 Gene

  • GC02M195817
  • GC02M196341
  • GC02M197592
  • GC02M197831
  • GC02M197454
  • GC02M197336
  • GC02M189481

Summaries for GTF3C3 Gene

Entrez Gene Summary for GTF3C3 Gene

  • The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GTF3C3 Gene

GTF3C3 (General Transcription Factor IIIC Subunit 3) is a Protein Coding gene. Diseases associated with GTF3C3 include tooth agenesis. Among its related pathways are Transcription of tRNA and Gene Expression.

UniProtKB/Swiss-Prot for GTF3C3 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C3 Gene

Genomics for GTF3C3 Gene

Regulatory Elements for GTF3C3 Gene

Enhancers for GTF3C3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF3C3 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF3C3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF3C3 Gene

Chromosome:
2
Start:
196,763,032 bp from pter
End:
196,799,768 bp from pter
Size:
36,737 bases
Orientation:
Minus strand

Genomic View for GTF3C3 Gene

Genes around GTF3C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C3 Gene

Proteins for GTF3C3 Gene

  • Protein details for GTF3C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q9-TF3C3_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 3
    Protein Accession:
    Q9Y5Q9
    Secondary Accessions:
    • Q4ZG48
    • Q86XJ8
    • Q8WX84
    • Q96B44
    • Q9H5I8
    • Q9NT97

    Protein attributes for GTF3C3 Gene

    Size:
    886 amino acids
    Molecular mass:
    101272 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1 and TBP.
    SequenceCaution:
    • Sequence=BAB15638.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF3C3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C3 Gene

Proteomics data for GTF3C3 Gene at MOPED

Post-translational modifications for GTF3C3 Gene

  • Ubiquitination at Lys 234, Lys 245, Lys 268, Lys 298, Lys 481, and Lys 595
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C3 Gene

Domains & Families for GTF3C3 Gene

Protein Domains for GTF3C3 Gene

Suggested Antigen Peptide Sequences for GTF3C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q9

UniProtKB/Swiss-Prot:

TF3C3_HUMAN :
  • Contains 11 TPR repeats.
Similarity:
  • Contains 11 TPR repeats.
genes like me logo Genes that share domains with GTF3C3: view

Function for GTF3C3 Gene

Molecular function for GTF3C3 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
genes like me logo Genes that share phenotypes with GTF3C3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C3 Gene

Localization for GTF3C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C3 Gene COMPARTMENTS Subcellular localization image for GTF3C3 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with GTF3C3: view

Pathways & Interactions for GTF3C3 Gene

genes like me logo Genes that share pathways with GTF3C3: view

Gene Ontology (GO) - Biological Process for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter IC,TAS 17409385
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with GTF3C3: view

No data available for SIGNOR curated interactions for GTF3C3 Gene

Drugs & Compounds for GTF3C3 Gene

No Compound Related Data Available

Transcripts for GTF3C3 Gene

Unigene Clusters for GTF3C3 Gene

General transcription factor IIIC, polypeptide 3, 102kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for GTF3C3 Gene

GeneLoc Exon Structure for
GTF3C3
ECgene alternative splicing isoforms for
GTF3C3

Expression for GTF3C3 Gene

mRNA expression in normal human tissues for GTF3C3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF3C3 Gene

This gene is overexpressed in Lung (9.7) and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C3 Gene



SOURCE GeneReport for Unigene cluster for GTF3C3 Gene Hs.470996

genes like me logo Genes that share expression patterns with GTF3C3: view

Protein tissue co-expression partners for GTF3C3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C3 Gene

Orthologs for GTF3C3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF3C3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF3C3 35
  • 91.79 (n)
  • 94.92 (a)
GTF3C3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C3 35
  • 92.98 (n)
  • 95.92 (a)
GTF3C3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c3 35
  • 89.64 (n)
  • 93.88 (a)
Gtf3c3 16
Gtf3c3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF3C3 35
  • 99.77 (n)
  • 99.77 (a)
GTF3C3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c3 35
  • 88.6 (n)
  • 93.54 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF3C3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-1364 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C3 35
  • 80.04 (n)
  • 89.09 (a)
GTF3C3 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488740 35
  • 72.75 (n)
  • 81.18 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.21469 35
gtf3c3 35
  • 65.75 (n)
  • 68.08 (a)
gtf3c3 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4700 35
fruit fly
(Drosophila melanogaster)
Insecta CG8950 37
  • 32 (a)
CG8950 35
  • 45.4 (n)
  • 34.68 (a)
CG8950 36
  • 28 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010426 35
  • 48.04 (n)
  • 36.68 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK856.13 37
  • 27 (a)
tag-315 35
  • 43.54 (n)
  • 30.62 (a)
tftc-3 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC4 36
  • 20 (a)
OneToOne
TFC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17680 35
  • 42.55 (n)
  • 24.35 (a)
rice
(Oryza sativa)
Liliopsida Os11g0266800 35
  • 43.04 (n)
  • 26.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for GTF3C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF3C3 Gene

ENSEMBL:
Gene Tree for GTF3C3 (if available)
TreeFam:
Gene Tree for GTF3C3 (if available)

Paralogs for GTF3C3 Gene

No data available for Paralogs for GTF3C3 Gene

Variants for GTF3C3 Gene

Sequence variations from dbSNP and Humsavar for GTF3C3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11559078 - 196,797,802(-) TGTCA(A/G/T)TGAAG reference, missense
rs721491 -- 196,780,456(-) ATTTC(C/T)TAATA intron-variant, utr-variant-3-prime
rs1574424 -- 196,763,491(+) TTATA(C/T)ACATG utr-variant-3-prime
rs1599992 -- 196,770,956(+) CCATA(C/T)ACAAG intron-variant
rs3209603 -- 196,773,013(-) ACTCA(A/T)TTTAT reference, missense

Variation tolerance for GTF3C3 Gene

Residual Variation Intolerance Score: 8.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C3 Gene

HapMap Linkage Disequilibrium report
GTF3C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3C3 Gene

Disorders for GTF3C3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF3C3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tooth agenesis
  • familial tooth agenesis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GTF3C3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C3
genes like me logo Genes that share disorders with GTF3C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF3C3 Gene

Publications for GTF3C3 Gene

  1. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for GTF3C3 Gene

Sources for GTF3C3 Gene

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