GTF3C3 Gene
protein-coding GIFtS: 49
GCID: GC02M197592
|
|
general transcription factor IIIC, polypeptide 3, 102kDa(Previous names: general transcription factor IIIC, polypeptide 3 (102kD)...)
| |
Aliases
for GTF3C3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| General Transcription Factor IIIC, Polypeptide 3, 102kDa1 2 | | TFIIIC 102 KDa Subunit2 3 | | TFIIIC1021 2 3 | | General Transcription Factor IIIC, Polypeptide 3 (102kD)1 | | TFiiiC2-1021 2 | | TFIIICgamma2 | | Transcription Factor IIIC Subunit Gamma2 3 | | General Transcription Factor 3C Polypeptide 32 | | TF3C-Gamma1 | | Transcription Factor IIIC 102 KDa Subunit3 |
Export aliases for GTF3C3 gene to outside databasesPrevious GC identifers: GC02M195817 GC02M196341 GC02M197831 GC02M197454 GC02M197336 GC02M189481 |
Summaries
for GTF3C3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GTF3C3:
The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear andcytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Twotranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: TF3C3_HUMAN, Q9Y5Q9Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of theDNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters
|
Genomic Views
for GTF3C3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GTF3C3 gene promoter:
Pax-6 HTF CUTL1 NF-kappaB LCR-F1 MEF-2A NF-kappaB2 HSF2 aMEF-2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GTF3C3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF3C3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1GTF3C3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M197592: view genomic region
(about GC identifiers)
Start:
|
197,627,756 bp from pter |
End:
|
197,664,449 bp from pter |
Size:
|
36,694 bases |
Orientation:
|
minus strand |
|
Proteins
for GTF3C3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TF3C3_HUMAN, Q9Y5Q9 (See
protein sequence)Recommended Name: General transcription factor 3C polypeptide 3 Size: 886 amino acids; 101272 Da
Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 andGTF3C6. Interacts with BRF1 and TBP
Subcellular location: Nucleus
Sequence caution: Sequence=BAB15638.1; Type=Erroneous initiation;
Secondary accessions: Q4ZG48 Q86XJ8 Q8WX84 Q96B44 Q9H5I8 Q9NT97Alternative splicing: 2 isoforms: Q9Y5Q9-1 Q9Y5Q9-2 (May be due to exon skipping)Explore the universe of human proteins at neXtProt for GTF3C3: NX_Q9Y5Q9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5Q9
GTF3C3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193703.1 NP_036218.1
ENSEMBL proteins: ENSP00000263956 ENSP00000391724 ENSP00000394065 ENSP00000398385 ENSP00000386465 ENSP00000389992 ENSP00000438797 ENSP00000406685 Reactome Protein details: Q9Y5Q9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GTF3C3 for ontologies About GeneDecksing
GTF3C3 Antibody Products:
Assay Products for GTF3C3: |
Protein
Domains /
Families
for GTF3C3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GTF3C3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y5Q9ProtoNet protein and cluster: Q9Y5Q9 UniProtKB/Swiss-Prot: TF3C3_HUMAN, Q9Y5Q9Similarity: Contains 11 TPR repeats |
Function
for GTF3C3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TF3C3_HUMAN, Q9Y5Q9Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of theDNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
GTF3C3 for ontologies About GeneDecksing
|
Pathways & Interactions
for GTF3C3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase III Transcription Initiation | | | 2 | Assembly of RNA Polymerase-III Initiation Complex | | | 3 | Transcription | | | 4 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF3C3
5/8 
Reactome Pathways for GTF3C3 (see all 8)
GTF3C3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF3C3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/613 Interacting proteins for GTF3C3 (Q9Y5Q92, 3 ENSP000002639564) via UniProtKB, MINT, STRING, and/or I2D (see all 613)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
GTF3C3 for ontologies About GeneDecksing
|
Drugs & Compounds
for GTF3C3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GTF3C3
Search CenterWatch for drugs/clinical trials and news about GTF3C3 / TF3C3
|
Transcripts
for GTF3C3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GTF3C3 gene (2 alternative transcripts): NM_001206774.1 NM_012086.4 Unigene Cluster for GTF3C3: General transcription factor IIIC, polypeptide 3, 102kDa Hs.470996 [show with all ESTs]Unigene Representative Sequence: NM_01208611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263956(uc002uts.3 uc010zgu.2) ENST00000481098 ENST00000416690
ENST00000435252 ENST00000448087(uc002utt.4) ENST00000466862 ENST00000409364(uc002utu.3)
ENST00000470386 ENST00000455546 ENST00000451088 ENST00000448539
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF3C3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C3 (NM_012086) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GTF3C3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C3 |
Additional cDNA sequence: AF085850.1 AF133123.1 AF465407.1 AK025560.1 AK027050.1 AK314718.1 AL137453.1 BC015995.1 BC026889.1 BC036952.2 BC043347.1 10 DOTS entries: DT.416377 DT.100790574 DT.95086071 DT.91974882 DT.416378 DT.95183773 DT.97802304 DT.99968395 DT.40130619 DT.97784338 24/197 AceView cDNA sequences (see all 197): AA307628 BM838928 AK027050 AW295143 CB160350 BM716869 AI206773 BX490235 BQ639359 CK824131 BC043347 BM693986 BM828123 AA258221 AA428238 AA478070 AA766807 BX106805 AI433661 BQ014932 BM857480 BM701479 AI635824 AA477615
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GTF3C3
|
Expression
for GTF3C3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GTF3C3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGGCTGGG
About this image
See GTF3C3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GTF3C3
SOURCE GeneReport for Unigene cluster: Hs.470996
SABiosciences Custom PCR Arrays for GTF3C3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTF3C3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GTF3C3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF3C3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF3C3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C3 |
Orthologs
for GTF3C3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GTF3C3 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for GTF3C3 (if available)
TreeFam Gene Tree for GTF3C3 (if available) |
Paralogs
for GTF3C3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GTF3C3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GTF3C3 (197627756 - 197664449 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GTF3C3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF3C3 |
|
Disorders
/ Diseases
for GTF3C3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GTF3C3 for disorders About GeneDecksing
OMIM gene information: 604888
OMIM disorders: --
4  diseases for GTF3C3: About MalaCardsectodermal dysplasia microcephaly influenza immunodeficiency
Export disorders for GTF3C3 gene to outside databases
|
Publications
for GTF3C3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GTF3C3 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with GTF3C3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PubMed id 10373544)1, 2, 3 Hsieh Y.-J.... Roeder R.G. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
|
External Searches for GTF3C3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GTF3C3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GTF3C3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GTF3C3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GTF3C3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GTF3C3 gene:
Search GeneIP for patents involving GTF3C3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GTF3C3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GTF3C3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF3C3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF3C3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GTF3C3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF3C3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF3C3 |
| |
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| |  |  |  |  | | | | |
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 | | | GTF3C3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C3 |
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