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Aliases for GTF3C3 Gene

Aliases for GTF3C3 Gene

  • General Transcription Factor IIIC, Polypeptide 3, 102kDa 2 3
  • Transcription Factor IIIC Subunit Gamma 3 4
  • TFIIIC 102 KDa Subunit 3 4
  • TF3C-Gamma 3 4
  • TFIIIC102 3 4
  • General Transcription Factor IIIC, Polypeptide 3 (102kD) 2
  • General Transcription Factor 3C Polypeptide 3 3
  • Transcription Factor IIIC 102 KDa Subunit 4
  • TFIIICgamma 3
  • TFiiiC2-102 3

External Ids for GTF3C3 Gene

Summaries for GTF3C3 Gene

Entrez Gene Summary for GTF3C3 Gene

  • The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GTF3C3 Gene

GTF3C3 (General Transcription Factor IIIC, Polypeptide 3, 102kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for GTF3C3 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C3 Gene

Genomics for GTF3C3 Gene

Genomic Location for GTF3C3 Gene

196,763,032 bp from pter
196,799,768 bp from pter
36,737 bases
Minus strand

Genomic View for GTF3C3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF3C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C3 Gene

Regulatory Elements for GTF3C3 Gene

Proteins for GTF3C3 Gene

  • Protein details for GTF3C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    General transcription factor 3C polypeptide 3
    Protein Accession:
    Secondary Accessions:
    • Q4ZG48
    • Q86XJ8
    • Q8WX84
    • Q96B44
    • Q9H5I8
    • Q9NT97

    Protein attributes for GTF3C3 Gene

    886 amino acids
    Molecular mass:
    101272 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1 and TBP.
    • Sequence=BAB15638.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF3C3 Gene


neXtProt entry for GTF3C3 Gene

Proteomics data for GTF3C3 Gene at MOPED

Post-translational modifications for GTF3C3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys41, Lys234, Lys245, Lys268, Lys298, Lys481, and Lys595

Other Protein References for GTF3C3 Gene

No data available for DME Specific Peptides for GTF3C3 Gene

Domains for GTF3C3 Gene

Gene Families for GTF3C3 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • GTF :General transcription factors

Protein Domains for GTF3C3 Gene

Suggested Antigen Peptide Sequences for GTF3C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 11 TPR repeats.:
    • Q9Y5Q9
genes like me logo Genes that share domains with GTF3C3: view

Function for GTF3C3 Gene

Molecular function for GTF3C3 Gene

UniProtKB/Swiss-Prot Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

Gene Ontology (GO) - Molecular Function for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IC 17409385
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with GTF3C3: view

miRNA for GTF3C3 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GTF3C3 Gene

Localization for GTF3C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C3 Gene

Subcellular locations from

Jensen Localization Image for GTF3C3 Gene COMPARTMENTS Subcellular localization image for GTF3C3 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C3: view

Pathways for GTF3C3 Gene

genes like me logo Genes that share pathways with GTF3C3: view

Gene Ontology (GO) - Biological Process for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter IC 17409385
GO:0042797 tRNA transcription from RNA polymerase III promoter IC 17409385
genes like me logo Genes that share ontologies with GTF3C3: view

Transcripts for GTF3C3 Gene

Unigene Clusters for GTF3C3 Gene

General transcription factor IIIC, polypeptide 3, 102kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2: -
SP4: -

Relevant External Links for GTF3C3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTF3C3 Gene

mRNA expression in normal human tissues for GTF3C3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF3C3 Gene

SOURCE GeneReport for Unigene cluster for GTF3C3 Gene Hs.470996

genes like me logo Genes that share expressions with GTF3C3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C3 Gene

Orthologs for GTF3C3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF3C3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTF3C3 35
  • 99.77 (n)
  • 99.77 (a)
GTF3C3 36
  • 100 (a)
(Bos Taurus)
Mammalia GTF3C3 35
  • 91.79 (n)
  • 94.92 (a)
GTF3C3 36
  • 94 (a)
(Canis familiaris)
Mammalia GTF3C3 35
  • 92.98 (n)
  • 95.92 (a)
GTF3C3 36
  • 96 (a)
(Mus musculus)
Mammalia Gtf3c3 35
  • 89.64 (n)
  • 93.88 (a)
Gtf3c3 16
Gtf3c3 36
  • 94 (a)
(Monodelphis domestica)
Mammalia GTF3C3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-1364 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Gtf3c3 35
  • 88.6 (n)
  • 93.54 (a)
(Gallus gallus)
Aves GTF3C3 35
  • 80.04 (n)
  • 89.09 (a)
GTF3C3 36
  • 87 (a)
(Anolis carolinensis)
Reptilia GTF3C3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488740 35
  • 72.75 (n)
  • 81.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4700 35
(Danio rerio)
Actinopterygii Dr.21469 35
gtf3c3 35
  • 65.75 (n)
  • 68.08 (a)
gtf3c3 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010426 35
  • 48.04 (n)
  • 36.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8950 35
  • 45.4 (n)
  • 34.68 (a)
CG8950 36
  • 28 (a)
CG8950 37
  • 32 (a)
(Caenorhabditis elegans)
Secernentea tag-315 35
  • 43.54 (n)
  • 30.62 (a)
tftc-3 36
  • 23 (a)
ZK856.13 37
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC4 36
  • 20 (a)
TFC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17680 35
  • 42.55 (n)
  • 24.35 (a)
(Oryza sativa)
Liliopsida Os11g0266800 35
  • 43.04 (n)
  • 26.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for GTF3C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF3C3 Gene

Gene Tree for GTF3C3 (if available)
Gene Tree for GTF3C3 (if available)

Paralogs for GTF3C3 Gene

No data available for Paralogs for GTF3C3 Gene

Variants for GTF3C3 Gene

Sequence variations from dbSNP and Humsavar for GTF3C3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs721491 -- 196,780,456(-) ATTTC(C/T)TAATA utr-variant-3-prime, intron-variant
rs1574424 -- 196,763,491(+) TTATA(C/T)ACATG utr-variant-3-prime
rs1599992 -- 196,770,956(+) CCATA(C/T)ACAAG intron-variant
rs3209603 -- 196,773,013(-) ACTCA(A/T)TTTAT missense, reference
rs3806507 -- 196,801,428(-) TAGGA(C/T)TGAAG upstream-variant-2KB

Relevant External Links for GTF3C3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3C3 Gene

Disorders for GTF3C3 Gene

No disorders were found for GTF3C3 Gene.

No data available for UniProtKB/Swiss-Prot for GTF3C3 Gene

Publications for GTF3C3 Gene

  1. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 3

Products for GTF3C3 Gene

Sources for GTF3C3 Gene

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