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GTF3C2 Gene

protein-coding   GIFtS: 55
GCID: GC02M027548

General Transcription Factor IIIC, Polypeptide 2, Beta 11...

(Previous names: general transcription factor IIIC, polypeptide 2 (beta subunit,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
General Transcription Factor IIIC, Polypeptide 2, Beta 110kDa1 2     TFIIIC 110 KDa Subunit2 3
Transcription Factor IIIC 110 KDa Subunit2 3     General Transcription Factor IIIC, Polypeptide 2 (Beta Subunit, 110kD)1
Transcription Factor IIIC Subunit Beta2 3     TFIIIC-BETA2
TF3C-beta2 3     General Transcription Factor 3C Polypeptide 22
TFIIIC1102 3     KIAA00113

External Ids:    HGNC: 46651   Entrez Gene: 29762   Ensembl: ENSG000001152077   OMIM: 6048835   UniProtKB: Q8WUA43   

Export aliases for GTF3C2 gene to outside databases

Previous GC identifers: GC02M027470 GC02M027641 GC02M027523 GC02M027460 GC02M027402 GC02M027290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GTF3C2 Gene:
GTF3C2 (general transcription factor IIIC, polypeptide 2, beta 110kDa) is a protein-coding gene. Diseases associated with GTF3C2 include kaposi's sarcoma, and sarcoma.

UniProtKB/Swiss-Prot: TF3C2_HUMAN, Q8WUA4
Function: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription
complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic
RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1

Gene Wiki entry for GTF3C2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF3C2 gene promoter:
         POU3F2   AP-2gamma   AREB6   CP2   Ik-2   AP-2beta   Chx10   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF3C2 promoter sequence
   Search Chromatin IP Primers for GTF3C2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF3C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

GTF3C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3C2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027548:  view genomic region     (about GC identifiers)

Start:
27,548,716 bp from pter      End:
27,579,868 bp from pter
Size:
31,153 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TF3C2_HUMAN, Q8WUA4 (See protein sequence)
Recommended Name: General transcription factor 3C polypeptide 2  
Size: 911 amino acids; 100680 Da
Subunit: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5
and GTF3C6
Secondary accessions: D6W557 Q16632 Q9BWI7
Alternative splicing: 2 isoforms:  Q8WUA4-1   Q8WUA4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GTF3C2: NX_Q8WUA4

Explore proteomics data for GTF3C2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys602
  • Modification sites at PhosphoSitePlus

  • See GTF3C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030598.1  NP_001512.1  

    ENSEMBL proteins: 
     ENSP00000352536   ENSP00000409043   ENSP00000399339   ENSP00000393429   ENSP00000414422  
     ENSP00000389518   ENSP00000408174   ENSP00000264720  
    Reactome Protein details: Q8WUA4

    GTF3C2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WUA4

    ProtoNet protein and cluster: Q8WUA4

    UniProtKB/Swiss-Prot: TF3C2_HUMAN, Q8WUA4
    Similarity: Contains 4 WD repeats


    GTF3C2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF3C2_HUMAN, Q8WUA4
    Function: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription
    complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic
    RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677contributes to DNA binding IDA17409385
    GO:0005515protein binding ----
         
    GTF3C2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF3C2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GTF3C2
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    miRNA
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    miRTarBase miRNAs that target GTF3C2:
    hsa-mir-92a-3p (MIRT049553), hsa-mir-10a-5p (MIRT047625), hsa-mir-16-5p (MIRT031765), hsa-mir-24-3p (MIRT030484)

    Block miRNA regulation of human, mouse, rat GTF3C2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GTF3C2 (see all 29):
    hsa-miR-124* hsa-miR-3685 hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-34b* hsa-miR-3135 hsa-miR-16-2* hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GTF3C2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C2 (NM_001521)
    Sino Biological Human cDNA Clone for GTF3C2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF3C2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TF3C2_HUMAN, Q8WUA4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000127transcription factor TFIIIC complex IDA17409385
    GO:0005654nucleoplasm TAS--

    GTF3C2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF3C2 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 1 Promoter0.77
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 2 Promoter0.74
    RNA Polymerase III Transcription0.88
    2Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex0.00
    Transcription of tRNA
    3RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    4Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF3C2
        Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex


    3 Reactome Pathways for GTF3C2
        RNA Polymerase III Transcription Initiation From Type 1 Promoter
    RNA Polymerase III Transcription Initiation From Type 2 Promoter
    RNA Polymerase III Abortive And Retractive Initiation



    GTF3C2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF3C2
    Interactions:

        GeneGlobe Interaction Network for GTF3C2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF3C2 (Q8WUA42, 3 ENSP000002647204) via UniProtKB, MINT, STRING, and/or I2D (see all 800)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF3C4Q9UKN82, 3, ENSP000003612194MINT-7945693 I2D: score=2 STRING: ENSP00000361219
    GTF3C3Q9Y5Q92, 3, ENSP000002639564MINT-7945693 I2D: score=1 STRING: ENSP00000263956
    POLR1CO151602, ENSP000003614654MINT-7945693 MINT-7947479 STRING: ENSP00000361465
    GTF3C5Q9Y5Q82, 3, ENSP000003611804MINT-7947479 I2D: score=1 STRING: ENSP00000361180
    SMARCAD1Q9H4L72, ENSP000003519474MINT-7945693 MINT-7947479 STRING: ENSP00000351947
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IDA17409385
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--
    GO:00427915S class rRNA transcription from RNA polymerase III type 1 promoter IC17409385
    GO:0042797tRNA transcription from RNA polymerase III promoter IC17409385

    GTF3C2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF3C2 (TF3C2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GTF3C2 gene (2 alternative transcripts): 
    NM_001035521.2  NM_001521.3  

    Unigene Cluster for GTF3C2:

    General transcription factor IIIC, polypeptide 2, beta 110kDa
    Hs.75782  [show with all ESTs]
    Unigene Representative Sequence: NM_001521
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359541(uc010eyy.1 uc002rju.1) ENST00000457098 ENST00000431028
    ENST00000495298 ENST00000454704 ENST00000415683 ENST00000484680 ENST00000470115
    ENST00000493511 ENST00000480989 ENST00000457748 ENST00000423998 ENST00000264720(uc002rjv.1 uc002rjw.1 uc010eyz.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat GTF3C2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GTF3C2 (see all 29):
    hsa-miR-124* hsa-miR-3685 hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-34b* hsa-miR-3135 hsa-miR-16-2* hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidGTF3C2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF3C2 (NM_001521)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF3C2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF3C2
    Primer
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    OriGene qPCR primer pairs and template standards for GTF3C2
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF3C2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF3C2
      QuantiTect SYBR Green Assays in human, mouse, rat GTF3C2
      QuantiFast Probe-based Assays in human, mouse, rat GTF3C2

    Additional mRNA sequence: 

    AF054988.1 AK307656.1 BC000212.2 BC020981.1 BT009799.1 BX647092.1 D13636.1 

    Selected DOTS entries (see all 27):

    DT.455148  DT.95221731  DT.75189166  DT.100715164  DT.91689313  DT.95199099  DT.100821152  DT.91764588 
    DT.95241974  DT.75130415  DT.95133212  DT.95177004  DT.120979406  DT.120979430  DT.100821153  DT.120979520 
    DT.100821146  DT.95080646  DT.100821148  DT.120979344  DT.120979467  DT.120979491  DT.95230683  DT.97787875 

    Selected AceView cDNA sequences (see all 379):

    BE856540 BU626067 AA989252 AU142251 BC020981 BE384487 BF846212 D13636 
    BI757793 AI077383 BT009799 BQ064244 BG760323 BG826874 AA922691 CN484701 
    BQ639061 AI925082 AA341833 BX117335 AA744708 T28789 BI335913 BE275571 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C2 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a ·
    SP1:                          -     -     -     -                                                                 -                       -                     
    SP2:              -     -     -     -                                                                             -                       -                     
    SP3:              -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                                                      -                     

    ExUns: 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                              -     -                                       
    SP2:                                                                                                            
    SP3:  -     -     -     -     -                                                                                 
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for GTF3C2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF3C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTCCCAA
    GTF3C2 Expression
    About this image


    GTF3C2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Lens
    GTF3C2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF3C2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75782
        Custom PCR Arrays for GTF3C2
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    QuantiFast Probe-based Assays in human, mouse, rat GTF3C2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF3C2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GTF3C2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf3c21 , 5 general transcription factor IIIC, polypeptide 2, beta1, 5 88.45(n)1
    88.96(a)1
      5 (17.15 cM)5
    717521  NM_027901.21  NP_082177.21 
     311511425 
    chicken
    (Gallus gallus)
    Aves GTF3C21 general transcription factor IIIC, polypeptide 2, beta more 63.6(n)
    63.6(a)
      430980  XM_428530.4  XP_428530.4 
    lizard
    (Anolis carolinensis)
    Reptilia GTF3C26
    general transcription factor IIIC, polypeptide 2, ...
    48(a)
    1 ↔ 1
    AAWZ02035537(3063-34005)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480308132   -- 73.47(n)    48030813 
    zebrafish
    (Danio rerio)
    Actinopterygii gtf3c21 general transcription factor IIIC, polypeptide 2, beta 52.98(n)
    43.26(a)
      563394  NM_001045018.2  NP_001038483.2 


    ENSEMBL Gene Tree for GTF3C2 (if available)
    TreeFam Gene Tree for GTF3C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for GTF3C2 (see all 574)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399962361,2
    --27548272(+) TGATCA/GCTTCT 2 -- int10--------
    rs1156105381,2
    F--27548507(+) TCACTG/AGGGTG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1434576551,2
    --27548510(+) CTGGGG/TTGTGT 2 -- int10--------
    rs621307161,2
    C,F--27548518(+) TGTCCC/TTGCTT 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1867061451,2
    --27548920(+) GTAGGA/GTCAGA 2 -- ut310--------
    rs1912866831,2
    --27549038(+) AACTTA/CAGTCT 2 -- ut310--------
    rs1838746531,2
    --27549105(+) TCAGAA/GGGCAG 2 -- ut310--------
    rs10498361,2
    C--27549334(-) CCTCCA/CCCAAC 2 -- ut311Minor allele frequency- C:0.00NA 2
    rs10498311,2
    C,H--27549385(-) TCTTTC/TTACAG 2 -- ut31 ese36Minor allele frequency- T:0.00MN NS EA NA 604
    rs1876953371,2
    C--27549562(+) AAGGCA/GATGGC 4 R C mis10--------

    HapMap Linkage Disequilibrium report for GTF3C2 (27548716 - 27579868 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GTF3C2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2654CNV Insertion18451855
    nsv873754CNV Loss21882294
    dgv4072n71CNV Loss21882294
    nsv833614CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF3C2
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF3C2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604883    OMIM disorders: --

    3 diseases for GTF3C2:    
    About MalaCards
    kaposi's sarcoma    sarcoma    cerebritis


    GTF3C2 for disorders           About GeneDecksing


    Export disorders for GTF3C2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF3C2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with GTF3C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. (PubMed id 7729686)1, 2, 3, 9 Sinn E.... Roeder R.G. (Genes Dev. 1995)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2976 HGNC: 4665 AceView: GTF3C2andMPV17 Ensembl:ENSG00000115207 euGenes: HUgn2976
    ECgene: GTF3C2 H-InvDB: GTF3C2

    (According to HUGE)
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    HUGE: KIAA0011

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF3C2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF3C2 gene:
    Search GeneIP for patents involving GTF3C2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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