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Aliases for GTF3C2 Gene

Aliases for GTF3C2 Gene

  • General Transcription Factor IIIC Subunit 2 2 3 5
  • General Transcription Factor IIIC, Polypeptide 2, Beta 110kDa 2 3
  • Transcription Factor IIIC 110 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Beta 3 4
  • TFIIIC 110 KDa Subunit 3 4
  • TF3C-Beta 3 4
  • TFIIIC110 3 4
  • General Transcription Factor IIIC, Polypeptide 2 (Beta Subunit, 110kD) 2
  • General Transcription Factor 3C Polypeptide 2 3
  • TFIIIC-BETA 3
  • KIAA0011 4

External Ids for GTF3C2 Gene

Previous GeneCards Identifiers for GTF3C2 Gene

  • GC02M027470
  • GC02M027641
  • GC02M027523
  • GC02M027460
  • GC02M027402
  • GC02M027548

Summaries for GTF3C2 Gene

GeneCards Summary for GTF3C2 Gene

GTF3C2 (General Transcription Factor IIIC Subunit 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for GTF3C2 Gene

  • Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Gene Wiki entry for GTF3C2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C2 Gene

Genomics for GTF3C2 Gene

Regulatory Elements for GTF3C2 Gene

Enhancers for GTF3C2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GTF3C2 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GTF3C2 Gene

Chromosome:
2
Start:
27,325,849 bp from pter
End:
27,357,034 bp from pter
Size:
31,186 bases
Orientation:
Minus strand

Genomic View for GTF3C2 Gene

Genes around GTF3C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C2 Gene

Proteins for GTF3C2 Gene

  • Protein details for GTF3C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA4-TF3C2_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 2
    Protein Accession:
    Q8WUA4
    Secondary Accessions:
    • D6W557
    • Q16632
    • Q9BWI7

    Protein attributes for GTF3C2 Gene

    Size:
    911 amino acids
    Molecular mass:
    100680 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

    Alternative splice isoforms for GTF3C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C2 Gene

Post-translational modifications for GTF3C2 Gene

  • Ubiquitination at Lys 602
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C2 Gene

Domains & Families for GTF3C2 Gene

Protein Domains for GTF3C2 Gene

Suggested Antigen Peptide Sequences for GTF3C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUA4

UniProtKB/Swiss-Prot:

TF3C2_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with GTF3C2: view

Function for GTF3C2 Gene

Molecular function for GTF3C2 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Gene Ontology (GO) - Molecular Function for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IDA 17409385
genes like me logo Genes that share ontologies with GTF3C2: view
genes like me logo Genes that share phenotypes with GTF3C2: view

Animal Model Products

CRISPR Products

miRNA for GTF3C2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C2 Gene

Localization for GTF3C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3C2 Gene COMPARTMENTS Subcellular localization image for GTF3C2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C2: view

Pathways & Interactions for GTF3C2 Gene

genes like me logo Genes that share pathways with GTF3C2: view

Gene Ontology (GO) - Biological Process for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA 17409385
GO:0006383 transcription from RNA polymerase III promoter IDA 17409385
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter IC 17409385
GO:0042797 tRNA transcription from RNA polymerase III promoter IC 17409385
genes like me logo Genes that share ontologies with GTF3C2: view

No data available for SIGNOR curated interactions for GTF3C2 Gene

Drugs & Compounds for GTF3C2 Gene

No Compound Related Data Available

Transcripts for GTF3C2 Gene

Unigene Clusters for GTF3C2 Gene

General transcription factor IIIC, polypeptide 2, beta 110kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - - -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - - -
SP8:
SP9: - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b
SP1: - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for GTF3C2 Gene

GeneLoc Exon Structure for
GTF3C2
ECgene alternative splicing isoforms for
GTF3C2

Expression for GTF3C2 Gene

mRNA expression in normal human tissues for GTF3C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF3C2 Gene

This gene is overexpressed in Serum (23.7) and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C2 Gene



Protein tissue co-expression partners for GTF3C2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF3C2 Gene:

GTF3C2

SOURCE GeneReport for Unigene cluster for GTF3C2 Gene:

Hs.75782
genes like me logo Genes that share expression patterns with GTF3C2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF3C2 Gene

Orthologs for GTF3C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF3C2 34
  • 90.98 (n)
  • 89.55 (a)
GTF3C2 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C2 34
  • 92.2 (n)
  • 93.74 (a)
GTF3C2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c2 34
  • 88.45 (n)
  • 88.96 (a)
Gtf3c2 16
Gtf3c2 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF3C2 34
  • 99.7 (n)
  • 100 (a)
GTF3C2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c2 34
  • 88.62 (n)
  • 89.21 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF3C2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C2 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C2 34
  • 63.6 (n)
  • 63.6 (a)
GTF3C2 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C2 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497817 34
  • 56.58 (n)
  • 50.2 (a)
zebrafish
(Danio rerio)
Actinopterygii gtf3c2 34
  • 52.98 (n)
  • 43.26 (a)
gtf3c2 35
  • 39 (a)
OneToOne
Species where no ortholog for GTF3C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C2 Gene

ENSEMBL:
Gene Tree for GTF3C2 (if available)
TreeFam:
Gene Tree for GTF3C2 (if available)

Paralogs for GTF3C2 Gene

No data available for Paralogs for GTF3C2 Gene

Variants for GTF3C2 Gene

Sequence variations from dbSNP and Humsavar for GTF3C2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1049817 -- 27,328,100(-) CCTCC(C/T)AAGGC reference, synonymous-codon
rs4665969 -- 27,352,086(+) CACTA(C/T)CCCTT intron-variant
rs6721927 -- 27,328,458(+) TGTTC(A/G)TATAC intron-variant
rs11126975 -- 27,344,122(+) tgggt(C/T)caagc intron-variant
rs6732797 -- 27,340,007(+) aaaaa(A/G)gggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF3C2 Gene

Variant ID Type Subtype PubMed ID
esv3575209 CNV gain 25503493
nsv2654 CNV insertion 18451855
nsv581244 CNV loss 21841781
nsv833614 CNV gain 17160897

Variation tolerance for GTF3C2 Gene

Residual Variation Intolerance Score: 4.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C2 Gene

Human Gene Mutation Database (HGMD)
GTF3C2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C2 Gene

Disorders for GTF3C2 Gene

Relevant External Links for GTF3C2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C2

No disorders were found for GTF3C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C2 Gene

Publications for GTF3C2 Gene

  1. Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. (PMID: 7729686) Sinn E. … Roeder R.G. (Genes Dev. 1995) 2 3 4 22 65
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4 65
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65

Products for GTF3C2 Gene

Sources for GTF3C2 Gene

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