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GTF3A Gene

protein-coding   GIFtS: 54
GCID: GC13P027998

General Transcription Factor IIIA

  See GTF3A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
General Transcription Factor IIIA1 2
TFIIIA2 3 5
AP22
Transcription Factor IIIA2

External Ids:    HGNC: 46621   Entrez Gene: 29712   Ensembl: ENSG000001220347   OMIM: 6008605   UniProtKB: Q926643   
ORGUL members:         

Export aliases for GTF3A gene to outside databases

Previous GC identifers: GC13P025978 GC13P021978 GC13P026928 GC13P025796 GC13P026896 GC13P008820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GTF3A Gene:
The product of this gene is a zinc finger protein with nine Cis(2)-His(2) zinc finger domains. It functions as an
RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50
bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a
stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA
polymerase III to form the complete transcription complex. The protein is thought to be translated using a
non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the
purified protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for GTF3A Gene:
GTF3A (general transcription factor IIIA) is a protein-coding gene. Diseases associated with GTF3A include prostate carcinoma in situ, and endocarditis. GO annotations related to this gene include RNA binding. An important paralog of this gene is ZXDA.

UniProtKB/Swiss-Prot: TF3A_HUMAN, Q92664
Function: Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is
required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May
initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes

Gene Wiki entry for GTF3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GTF3A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF3A promoter sequence
   Search Chromatin IP Primers for GTF3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13.1   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.3-q13.1

GTF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF3A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P027998:  view genomic region     (about GC identifiers)

Start:
27,998,681 bp from pter      End:
28,009,958 bp from pter
Size:
11,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TF3A_HUMAN, Q92664 (See protein sequence)
Recommended Name: Transcription factor IIIA  
Size: 365 amino acids; 41515 Da
Caution: It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian
TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well
conserved among mammals
Sequence caution: Sequence=BAA06988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA06988.1; Type=Frameshift; Positions=319, 330;
Secondary accessions: B7ZBK5 Q12963 Q13097
Alternative splicing: 2 isoforms:  Q92664-1   Q92664-2   

Explore the universe of human proteins at neXtProt for GTF3A: NX_Q92664

Explore proteomics data for GTF3A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GTF3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002088.2  
    ENSEMBL proteins: 
     ENSP00000370532   ENSP00000409175   ENSP00000389655   ENSP00000387806   ENSP00000393050  
    Reactome Protein details: Q92664

    GTF3A Human Recombinant Protein Products:

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    antibodies-online peptides for GTF3A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q92664

    ProtoNet protein and cluster: Q92664

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: TF3A_HUMAN, Q92664
    Similarity: Contains 9 C2H2-type zinc fingers


    Find genes that share domains with GTF3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF3A_HUMAN, Q92664
    Function: Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is
    required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May
    initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes

         Genatlas biochemistry entry for GTF3A:
    general transcription factor IIIA,Xenopus homolog,required for initiation of transcription of 5S RNA

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with GTF3A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GTF3A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TF3A_HUMAN, Q92664: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with GTF3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF3A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription0.88
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 1 Promoter0.77
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    3Gene Expression
    Gene Expression0.40
    4Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex0.00
    5IL4-mediated signaling events
    IL4-mediated signaling events


    Find genes that share SuperPaths with GTF3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GTF3A
        Assembly of RNA Polymerase-III Initiation Complex

    2 BioSystems Pathways for GTF3A
        Adipogenesis
    IL4-mediated signaling events

    2 Reactome Pathways for GTF3A
        RNA Polymerase III Transcription Initiation From Type 1 Promoter
    RNA Polymerase III Abortive And Retractive Initiation


        Pathway & Disease-focused RT2 Profiler PCR Array including GTF3A: 
              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GTF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF3A (Q926643 ENSP000003705324) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    EPN1Q9Y6I33, ENSP000004062094I2D: score=1 STRING: ENSP00000406209
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    GTF3C2Q8WUA43, ENSP000002647204I2D: score=2 STRING: ENSP00000264720
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0009303rRNA transcription TAS8063702
    GO:0010467gene expression TAS--

    Find genes that share ontologies with GTF3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF3A (TF3A)

    Selected Novoseek inferred chemical compound relationships for GTF3A gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5s-rrna 70.3 9 8557698 (2), 10559190 (2)
    zinc 70 162 8336715 (6), 9242690 (6), 8419919 (5), 8411165 (5) (see all 62)
    cpds 43.1 5 15913668 (3), 10064604 (1)
    rrna 35.8 19 19211543 (4), 7729570 (3), 9426240 (2), 11926995 (2) (see all 8)
    fibrinogen 34.1 9 18558494 (2), 16045623 (1), 20007717 (1), 16640587 (1) (see all 6)
    histidine 26.4 4 12665246 (1), 1511742 (1), 8411165 (1)
    cyanogen bromide 16.7 1 11853545 (1)
    cysteine 5.91 3 12665246 (1), 1511742 (1)
    serine 5.52 10 11853545 (2), 16650464 (1), 19415717 (1), 16251496 (1) (see all 9)
    pravastatin 5.4 2 8759384 (1), 8966112 (1)



    Find genes that share compounds with GTF3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GTF3A gene: 
    NM_002097.2  

    Unigene Cluster for GTF3A:

    General transcription factor IIIA
    Hs.445977  [show with all ESTs]
    Unigene Representative Sequence: AK057993
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381140(uc001ure.2 uc001urf.2) ENST00000435781 ENST00000419181
    ENST00000438571 ENST00000466776 ENST00000470606(uc001urg.2) ENST00000493903
    ENST00000439403 ENST00000482655
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    Additional mRNA sequence: 

    AK057993.1 AK130295.1 BC143711.1 D32257.1 U14134.1 U20272.1 

    19 DOTS entries:

    DT.95303395  DT.100820167  DT.91941950  DT.452672  DT.91960847  DT.100773125  DT.87008500  DT.91763823 
    DT.100739738  DT.107228  DT.91763828  DT.100820163  DT.120769632  DT.100820169  DT.91876450  DT.95303407 
    DT.100820164  DT.120769642  DT.120769652 

    Selected AceView cDNA sequences (see all 438):

    BG036660 BU619505 CB140928 BM809479 AU105002 BM553401 BQ279125 CR596081 
    BF223795 BU517107 CB112838 BM551678 BU957153 BE889997 AI075001 BU857459 
    BE733517 BM832150 U20272 BE047182 BG335031 CA431439 AW026082 BQ278693 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GTF3A (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                          -     -     -     -                 -                       -     -     -                 -                           
    SP2:                                                              -                       -     -     -                 -                           
    SP3:                          -     -     -     -                 -                       -     -     -     -           -                           
    SP4:                                                              -                       -     -     -     -           -                           
    SP5:                                                                                      -     -     -                 -                           


    ECgene alternative splicing isoforms for GTF3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GTF3A Expression
    About this image


    GTF3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
    GTF3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445977

    UniProtKB/Swiss-Prot: TF3A_HUMAN, Q92664
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including GTF3A: 
              Mesenchymal Stem Cell in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GTF3A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf3a1 , 5 general transcription factor III A1, 5 80.2(n)1
    78.45(a)1
      5 (86.57 cM)5
    665961  NM_025652.31  NP_079928.21 
     1469486575 
    chicken
    (Gallus gallus)
    Aves GTF3A1 general transcription factor IIIA 68.18(n)
    66.48(a)
      418931  NM_001113571.1  NP_001107043.1 
    lizard
    (Anolis carolinensis)
    Reptilia GTF3A6
    general transcription factor IIIA
    60(a)
    1 ↔ 1
    GL343306.1(1156868-1170739)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977772 TFIIIA mRNA 75.22(n)    K02938.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147502 Transcribed sequence with weak similarity to protein more 70.84(n)    CA474391.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96091 , 3 RNA polymerase III transcription
    factor3
    CG96091
    32(a)3
    42.89(n)1
    34.88(a)1
      15A83
    326631  NM_132933.21  NP_573161.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWI56
    ACE26
    Transcription factor that activates transcription ...
    Transcription factor required for septum destructi...
    6(a)
    5(a)
    many ↔ many
    many ↔ many
    IV(748613-750742) YDR146C
    XII(404510-406822) YLR131C


    ENSEMBL Gene Tree for GTF3A (if available)
    TreeFam Gene Tree for GTF3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GTF3A gene
    ZXDA2  ZXDC2  ZXDB2  
    Selected SIMAP similar genes for GTF3A using alignment to 5 protein entries:     TF3A_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O1631    SP3    DKFZp686N0199    KLF13    YY1    A-328A3.4
    FIZ1    SP1    ZNF55    ZNF181    ZNF83    KLF1
    MYNN    ZNF423    ZNF211    ZNF544    KLF16    ZBTB47

    Find genes that share paralogs with GTF3A           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for GTF3A (see all 6)
    PGOHUM00000247850 PGOHUM00000241122 PGOHUM00000235719 PGOHUM00000232598 PGOHUM00000232973


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GTF3A (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002354531,2
    C--27996694(+) AACAT-/GGTAAA 1 -- us2k10--------
    rs1458723081,2
    --27996746(+) TGGTGC/TGCACC 1 -- us2k10--------
    rs37594351,2
    C,F,H--27996813(-) CTGCAA/CCCTCC 1 -- us2k17Minor allele frequency- C:0.26NA CSA WA EA 366
    rs1125643741,2
    C--27996882(+) TTGTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs2009446761,2
    C--27996890(+) AAAAA-/AAAG  
            
    AAAGA
    1 -- us2k10--------
    rs799045931,2
    --27996893(+) AAAAAG/AAAAGA 1 -- us2k12Minor allele frequency- A:0.19NA 122
    rs2015541231,2
    C--27996893(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1378916841,2
    --27996938(+) GCAGAA/GAGAAA 1 -- us2k10--------
    rs1842936951,2
    --27996978(+) AAAGAA/GCAAAG 1 -- us2k10--------
    rs777775071,2
    C,F--27997028(+) GATCCT/CATTAG 1 -- us2k11Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for GTF3A (27998681 - 28009958 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GTF3A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF3A
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600860    OMIM disorders: --

    2 diseases for GTF3A:    
    About MalaCards
    prostate carcinoma in situ    endocarditis

    1 disease from the University of Copenhagen DISEASES database for GTF3A:
    Prostate carcinoma in situ

    Find genes that share disorders with GTF3A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GTF3A gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypomania 25.1 1 15536301 (1)
    breast cancer 4.22 2 17353919 (1), 16708380 (1)
    psychiatric disorder 3.52 1 15962922 (1)
    stroke 2.98 1 15491926 (1)
    metastasis 2.7 1 19816005 (1)
    necrosis 0 5 9696492 (1), 11005132 (1), 11259850 (1), 11834836 (1)
    inflammation 0 2 15026723 (1), 20470300 (1)
    tumors 0 12 11814676 (1), 15317818 (1), 2016567 (1), 9696492 (1) (see all 10)
    cancer 0 2 17448239 (1), 19765756 (1)
    endocarditis 0 1 17393025 (1)


    Export disorders for GTF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF3A gene, integrated from 10 sources (see all 199):
    (articles sorted by number of sources associating them with GTF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. (PubMed id 7789179)1, 2, 3, 9 Arakawa H.... Nakamura Y. (Cytogenet. Cell Genet. 1995)
    2. Purification and characterization of human transcription factor IIIA. (PubMed id 8063702)1, 2, 9 Moorefield B. and Roeder R.G. (J. Biol. Chem. 1994)
    3. Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA. (PubMed id 7622052)1, 2, 9 Drew P.D....Becker K.G. (Gene 1995)
    4. cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA. (PubMed id 11814676)1, 9 Hanas J.S....Moreland R.J. (Gene 2002)
    5. Identification of a transcription factor IIIA-interacting protein. (PubMed id 10756201)1, 9 Moreland R.J.... Hanas J.S. (Nucleic Acids Res. 2000)
    6. Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. (PubMed id 8610146)1, 9 Fridell R.A....Cullen B.R. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2971 HGNC: 4662 AceView: GTF3A Ensembl:ENSG00000122034 euGenes: HUgn2971
    ECgene: GTF3A H-InvDB: GTF3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF3A gene:
    Search GeneIP for patents involving GTF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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