External Ids for GTF3A Gene
Previous GeneCards Identifiers for GTF3A Gene
The product of this gene is a zinc finger protein with nine Cis-His zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for GTF3A Gene
GTF3A (General Transcription Factor IIIA) is a Protein Coding gene. Diseases associated with GTF3A include Thrombasthenia. Among its related pathways are RNA Polymerase III Transcription Initiation and IL4-mediated signaling events. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ZXDC.
UniProtKB/Swiss-Prot for GTF3A Gene
Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNAs. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.