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Aliases for GTF3A Gene

Aliases for GTF3A Gene

  • General Transcription Factor IIIA 2 3
  • TFIIIA 3 4
  • AP2 3

External Ids for GTF3A Gene

Previous GeneCards Identifiers for GTF3A Gene

  • GC13P025978
  • GC13P021978
  • GC13P026928
  • GC13P025796
  • GC13P026896
  • GC13P027998
  • GC13P008820

Summaries for GTF3A Gene

Entrez Gene Summary for GTF3A Gene

  • The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF3A Gene

GTF3A (General Transcription Factor IIIA) is a Protein Coding gene. Diseases associated with GTF3A include thrombasthenia. Among its related pathways are IL4-mediated signaling events and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ZXDC.

UniProtKB/Swiss-Prot for GTF3A Gene

  • Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNAs. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes

Gene Wiki entry for GTF3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3A Gene

Genomics for GTF3A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GTF3A Gene

Chromosome:
13
Start:
27,424,544 bp from pter
End:
27,435,823 bp from pter
Size:
11,280 bases
Orientation:
Plus strand

Genomic View for GTF3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3A Gene

No data available for Regulatory Elements for GTF3A Gene

Proteins for GTF3A Gene

  • Protein details for GTF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92664-TF3A_HUMAN
    Recommended name:
    Transcription factor IIIA
    Protein Accession:
    Q92664
    Secondary Accessions:
    • B7ZBK5
    • Q12963
    • Q13097

    Protein attributes for GTF3A Gene

    Size:
    365 amino acids
    Molecular mass:
    41515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA06988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA06988.1; Type=Frameshift; Positions=319, 330; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3A Gene

Proteomics data for GTF3A Gene at MOPED

Post-translational modifications for GTF3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF3A Gene

Antibody Products

No data available for DME Specific Peptides for GTF3A Gene

Domains & Families for GTF3A Gene

Protein Domains for GTF3A Gene

Suggested Antigen Peptide Sequences for GTF3A Gene

Graphical View of Domain Structure for InterPro Entry

Q92664

UniProtKB/Swiss-Prot:

TF3A_HUMAN :
  • Contains 9 C2H2-type zinc fingers.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with GTF3A: view

Function for GTF3A Gene

Molecular function for GTF3A Gene

GENATLAS Biochemistry:
general transcription factor IIIA,Xenopus homolog,required for initiation of transcription of 5S RNA
UniProtKB/Swiss-Prot Function:
Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNAs. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes

Gene Ontology (GO) - Molecular Function for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GTF3A: view
genes like me logo Genes that share phenotypes with GTF3A: view

Animal Model Products

miRNA for GTF3A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTF3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3A Gene

Localization for GTF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF3A Gene COMPARTMENTS Subcellular localization image for GTF3A gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3A: view

Pathways & Interactions for GTF3A Gene

genes like me logo Genes that share pathways with GTF3A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0009303 rRNA transcription TAS 8063702
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with GTF3A: view

No data available for SIGNOR curated interactions for GTF3A Gene

Drugs & Compounds for GTF3A Gene

(10) Drugs for GTF3A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pravastatin Approved Pharma 142
Zinc Approved Pharma 1404
Adenine Approved Nutra 0
Vitamin A Approved Nutra 386
thymidine Experimental Pharma 0

(12) Additional Compounds for GTF3A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5S-rRNA
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
CPDS
Cyanogen bromide
FIBRINOGEN
genes like me logo Genes that share compounds with GTF3A: view

Transcripts for GTF3A Gene

Unigene Clusters for GTF3A Gene

General transcription factor IIIA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTF3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - -
SP9: -
SP10: - - - -
SP11:

Relevant External Links for GTF3A Gene

GeneLoc Exon Structure for
GTF3A
ECgene alternative splicing isoforms for
GTF3A

Expression for GTF3A Gene

mRNA expression in normal human tissues for GTF3A Gene

Protein differential expression in normal tissues from HIPED for GTF3A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GTF3A Gene



SOURCE GeneReport for Unigene cluster for GTF3A Gene Hs.445977

mRNA Expression by UniProt/SwissProt for GTF3A Gene

Q92664-TF3A_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with GTF3A: view

Protein tissue co-expression partners for GTF3A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GTF3A Gene

Orthologs for GTF3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF3A 35
  • 80.41 (n)
  • 80.79 (a)
GTF3A 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3A 35
  • 86.2 (n)
  • 85.56 (a)
GTF3A 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3a 35
  • 80.2 (n)
  • 78.45 (a)
Gtf3a 16
Gtf3a 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF3A 35
  • 99.63 (n)
  • 99.73 (a)
GTF3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3a 35
  • 80.94 (n)
  • 79.83 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF3A 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3A 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3A 35
  • 68.18 (n)
  • 66.48 (a)
GTF3A 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3A 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3a 35
  • 61.06 (n)
  • 57.39 (a)
Str.17731 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397777 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14750 35
gtf3aa 35
  • 61.49 (n)
  • 59.66 (a)
GTF3A (2 of 3) 36
  • 29 (a)
OneToMany
gtf3aa 36
  • 47 (a)
OneToMany
gtf3ab 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9609 37
  • 32 (a)
CG9609 35
  • 42.89 (n)
  • 34.88 (a)
CG9609 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 36
  • 5 (a)
ManyToMany
SWI5 36
  • 6 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sfc2 35
  • 50 (n)
  • 40.87 (a)
Species with no ortholog for GTF3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3A Gene

ENSEMBL:
Gene Tree for GTF3A (if available)
TreeFam:
Gene Tree for GTF3A (if available)

Paralogs for GTF3A Gene

Paralogs for GTF3A Gene

genes like me logo Genes that share paralogs with GTF3A: view

Variants for GTF3A Gene

Sequence variations from dbSNP and Humsavar for GTF3A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_014824 -

Variation tolerance for GTF3A Gene

Residual Variation Intolerance Score: 55.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3A Gene

HapMap Linkage Disequilibrium report
GTF3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3A Gene

Disorders for GTF3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF3A Gene - From: GeneCards

Disorder Aliases PubMed IDs
thrombasthenia
- elite association
Search GTF3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for GTF3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3A
genes like me logo Genes that share disorders with GTF3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF3A Gene

Publications for GTF3A Gene

  1. Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. (PMID: 7789179) Arakawa H. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 23 67
  2. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. (PMID: 19951697) ThAcoleyre S. … Denis M.G. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. (PMID: 20007717) Geoghegan J.A. … Foster T.J. (J. Biol. Chem. 2010) 23 67
  4. Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis. (PMID: 20100856) Hair P.S. … Cunnion K.M. (Infect. Immun. 2010) 23 67
  5. An RNA aptamer with high affinity and high specificity for the 5S RNA binding zinc finger proteins TFIIIA and p43. (PMID: 20095591) Weiss T.C. … Romaniuk P.J. (Biochemistry 2010) 23 67

Products for GTF3A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GTF3A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GTF3A
    • Block miRNA regulation of GTF3A using miScript Target Protectors

    Sources for GTF3A Gene

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