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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GTF2H5 Gene

protein-coding   GIFtS: 53
GCID: GC06P158509

General Transcription Factor IIH, Polypeptide 5

(Previous names: chromosome 6 open reading frame 175, trichothiodystrophy)
(Previous symbols: C6orf175, TTD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
General Transcription Factor IIH, Polypeptide 51 2     trichothiodystrophy1
C6orf1751 2 3 5     TFIIH2
TTDA2 3 5     TGF2H52
TTD1 2     TTD-A2
TFB5 Ortholog2 3     bA120J8.22
TFIIH Basal Transcription Factor Complex TTD-A Subunit2 3     General Transcription Factor IIH Subunit 52
TFB52 5     TFIIH Basal Transcription Factor Complex TTDA Subunit2
Chromosome 6 Open Reading Frame 1751     General Transcription Factor IIH Polypeptide 53
DNA Repair Syndrome Trichothiodystrophy Group A1     

External Ids:    HGNC: 211571   Entrez Gene: 4046722   Ensembl: ENSG000002720477   OMIM: 6087805   UniProtKB: Q6ZYL43   

Export aliases for GTF2H5 gene to outside databases

Previous GC identifers: GC06P158559 GC06P156060


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GTF2H5 Gene:
This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA
repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is
implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy,
complementation group A. (provided by RefSeq, Mar 2009)

GeneCards Summary for GTF2H5 Gene: 
GTF2H5 (general transcription factor IIH, polypeptide 5) is a protein-coding gene. Diseases associated with GTF2H5 include trichothiodystrophy, complementation group a, and autosomal recessive disease, and among its related super-pathways are Assembly of RNA Polymerase-II Initiation Complex and Transcription P53 signaling pathway. GO annotations related to this gene include DNA binding.

UniProtKB/Swiss-Prot: TF2H5_HUMAN, Q6ZYL4
Function: Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA
and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH
complex and for the presence of normal levels of TFIIH in the cell

Gene Wiki entry for GTF2H5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTF2H5 gene promoter:
         USF1   Sp1   Pax-5   SREBP-1c   USF2   USF-1:USF-2   E4BP4   AREB6   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GTF2H5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GTF2H5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF2H5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

GTF2H5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2H5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P158509:  view genomic region     (about GC identifiers)

Start:
158,589,379 bp from pter      End:
158,620,376 bp from pter
Size:
30,998 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TF2H5_HUMAN, Q6ZYL4 (See protein sequence)
Recommended Name: General transcription factor IIH subunit 5  
Size: 71 amino acids; 8053 Da
Subunit: Subunit of the TFIIH basal transcription factor complex that contains ERCC2, ERCC3, GTF2H1, GTF2H2,
GTF2H3, GTF2H4, GTF2H5, MNAT1, CDK7 and CCNH
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for GTF2H5:
1YDL (3D)        2JNJ (3D)    
Secondary accessions: Q0P5V8

Explore the universe of human proteins at neXtProt for GTF2H5: NX_Q6ZYL4

Explore proteomics data for GTF2H5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZYL4

  • GTF2H5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GTF2H5 Protein Expression
    REFSEQ proteins: NP_997001.1  
    ENSEMBL proteins: 
     ENSP00000476100  

    Human Recombinant Protein Products for GTF2H5: 
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    Cloud-Clone Corp. Proteins for GTF2H5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000439core TFIIH complex IEA--

    GTF2H5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TFIIH: General transcription factor IIH complex subunits
    GTF: General transcription factors

    1 InterPro protein domain:
     IPR009400 TFIIH_TTDA/Tfb5

    Graphical View of Domain Structure for InterPro Entry Q6ZYL4

    ProtoNet protein and cluster: Q6ZYL4

    UniProtKB/Swiss-Prot: TF2H5_HUMAN, Q6ZYL4
    Similarity: Belongs to the TFB5 family


    GTF2H5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF2H5_HUMAN, Q6ZYL4
    Function: Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA
    and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH
    complex and for the presence of normal levels of TFIIH in the cell

    Phenotypes:
         2 GenomeRNAi human phenotypes for GTF2H5:

     Increased S DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GTF2H5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GTF2H5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GTF2H5 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGTF2H5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GTF2H5 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Transcription P53 signaling pathway
    Transcription P53 signaling pathway0.98
    3Global Genomic NER (GG-NER)
    Nucleotide excision repair0.70
    4PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for GTF2H5
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription P53 signaling pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF2H5 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Estrogen Pathway
    Transcription of mRNA

    2 GeneGo (Thomson Reuters) Pathways for GTF2H5
        Transcription P53 signaling pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    2         Kegg Pathways  (Kegg details for GTF2H5):
        Basal transcription factors
    Nucleotide excision repair


    GTF2H5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF2H5

    3 Interacting proteins for GTF2H5 (Q6ZYL43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK7P506133I2D: score=3 
    ERCC3P194473I2D: score=2 
    GTF2H2Q138883I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006289nucleotide-excision repair IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    GTF2H5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTF2H5 (TF2H5)

    Search CenterWatch for drugs/clinical trials and news about GTF2H5 / TF2H5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GTF2H5 gene: 
    NM_207118.2  

    Unigene Cluster for GTF2H5:

    General transcription factor IIH, polypeptide 5
    Hs.356224  [show with all ESTs]
    Unigene Representative Sequence: NM_207118
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000607778
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF2H5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF2H5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF2H5

    Additional mRNA sequence: 

    AJ634743.1 AK024874.1 AK055106.1 AK129771.1 BC004568.2 BC056906.1 BC060317.1 U92024.1 
    U92025.1 

    6 DOTS entries:

    DT.314085  DT.103084  DT.65284706  DT.121346979  DT.97813989  DT.97841349 

    24/129 AceView cDNA sequences (see all 129):

    AJ634743 BC056906 AJ243237 BP871236 AA156987 AW006736 BC004568 BX103497 
    AI435530 AA458752 AA921794 AA932402 AA448915 BM931276 BE645705 AI004298 
    AI861841 AA406434 BQ011925 NM_207118 AI223404 BM021366 CA771315 AI276209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GTF2H5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GTF2H5 Expression
    About this image


    See GTF2H5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GTF2H5

    SOURCE GeneReport for Unigene cluster: Hs.356224
        SABiosciences Custom PCR Arrays for GTF2H5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GTF2H5 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2h51 , 5 general transcription factor IIH, polypeptide 51, 5 87.32(n)1
    98.59(a)1
      17 (3.70 cM)5
    664671  NM_181392.31  NP_852057.21 
     60797865 
    chicken
    (Gallus gallus)
    Aves GTF2H51 general transcription factor IIH, polypeptide 5 82.16(n)
    90.14(a)
      769754  NM_001097535.1  NP_001091004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gtf2h51 general transcription factor IIH, polypeptide 5 74.4(n)
    80.36(a)
      751713  NM_001134362.1  NP_001127834.1 


    ENSEMBL Gene Tree for GTF2H5 (if available)
    TreeFam Gene Tree for GTF2H5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/659 SNPs in GTF2H5 are shown (see all 659)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0226474
    Trichothiodystrophy photosensitive (TTDP)4--see VAR_0226472 L P mis40--------
    rs345829741,2
    C--158590870(+) CACAC-/AC    
       
    /ATAC
    GATAC
    1 -- int12NA CSA 4
    rs1818049091,2
    --158591337(+) TAATTC/TTGTTA 1 -- int10--------
    rs1115911141,2
    F--158591427(+) GCCTCG/ATTTCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1475839691,2
    --158591435(+) TCAGAA/GGCAGA 1 -- int10--------
    rs753273141,2
    C,F--158591478(+) ATTTAA/GTGTTA 1 -- int11Minor allele frequency- G:0.05NA 120
    rs1124326461,2
    C--158591499(+) TTTATA/G/TAGCAT 1 -- int11CSA 1
    rs69315321,2
    C,F,A,H--158591619(+) AATCTT/GGACTT 1 -- int111Minor allele frequency- G:0.14NS EA NA WA 1382
    rs1864546231,2
    --158591717(+) TGCAAA/GGCTCC 1 -- int10--------
    rs1912256571,2
    --158591736(+) GATTTC/TAGTCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GTF2H5 (158589379 - 158620376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GTF2H5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1252764CNV Insertion17803354
    nsv830849CNV Loss17160897
    nsv823889CNV Loss20364138
    nsv886797CNV Gain21882294


    Human Gene Mutation Database (HGMD): GTF2H5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF2H5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608780   
    OMIM disorders: 601675  
    UniProtKB/Swiss-Prot: TF2H5_HUMAN, Q6ZYL4
  • Trichothiodystrophy photosensitive (TTDP) [MIM:601675]: TTDP is an autosomal recessive disease
    characterized by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual
    development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER)
    defect. Neonates with trichothiodystrophy and ichthyosis are usually born with a collodion membrane. The severity
    of the ichthyosis after the membrane is shed is variable, ranging from a mild to severe lamellar ichthyotic
    phenotype. There are no reports of skin cancer associated with TTDP. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for GTF2H5:    About MalaCards
    trichothiodystrophy, complementation group a    autosomal recessive disease    skin cancer    ichthyosis
    xeroderma pigmentosum    tetanus    meningioma    multiple sclerosis
    mental retardation

    3 diseases from the University of Copenhagen DISEASES database for GTF2H5:
    Photosensitive trichothiodystrophy     Cockayne syndrome     Xeroderma pigmentosum

    GTF2H5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for GTF2H5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trichothiodystrophy 95.9 2 11062469 (1), 12393803 (1)

    Genetic Association Database (GAD): GTF2H5
    Human Genome Epidemiology (HuGE) Navigator: GTF2H5 (3 documents)

    Export disorders for GTF2H5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GTF2H5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with GTF2H5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A and stabilizes TFIIH. (PubMed id 15220921)1, 2, 3, 9 Giglia-Mari G....Vermeulen W. (2004)
    2. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. (PubMed id 16669699)1, 9 Giglia-Mari G....Vermeulen W. (2006)
    6. Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder. (PubMed id 11062469)1, 9 Vermeulen W....Egly J.M. (2000)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Comprehensive analysis of DNA repair gene variants and risk of meningioma. (PubMed id 18270339)1 Bethke L....Houlston R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 404672 HGNC: 21157 AceView: GTF2H5 Ensembl:ENSG00000272047 euGenes: HUgn404672
    ECgene: GTF2H5 Kegg: 404672 H-InvDB: GTF2H5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GTF2H5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GTF2H5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GTF2H5 gene:
    Search GeneIP for patents involving GTF2H5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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