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Aliases for GTF2H2C Gene

Aliases for GTF2H2C Gene

  • GTF2H2 Family Member C 2 3 5
  • General Transcription Factor IIH Polypeptide 2-Like Protein 3 4
  • General Transcription Factor IIH, Polypeptide 2C 2 3
  • GTF2H2C GTF2H2C_2 4
  • GTF2H2C_2 3
  • GTF2H2D 4

External Ids for GTF2H2C Gene

Previous GeneCards Identifiers for GTF2H2C Gene

  • GC05P068897
  • GC05P068762
  • GC05P068856

Summaries for GTF2H2C Gene

GeneCards Summary for GTF2H2C Gene

GTF2H2C (GTF2H2 Family Member C) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and RNA Polymerase II Transcription Initiation And Promoter Clearance. An important paralog of this gene is GTF2H2.

UniProtKB/Swiss-Prot for GTF2H2C Gene

  • Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2H2C Gene

Genomics for GTF2H2C Gene

Regulatory Elements for GTF2H2C Gene

Enhancers for GTF2H2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF2H2C on UCSC Golden Path with GeneCards custom track

Promoters for GTF2H2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF2H2C on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF2H2C Gene

69,560,143 bp from pter
69,594,723 bp from pter
34,581 bases
Plus strand

Genomic View for GTF2H2C Gene

Genes around GTF2H2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2H2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2H2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2H2C Gene

Proteins for GTF2H2C Gene

  • Protein details for GTF2H2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    General transcription factor IIH subunit 2-like protein
    Protein Accession:
    Secondary Accessions:
    • A6NED9
    • A8K8J6
    • B2RCU4
    • B7ZW39

    Protein attributes for GTF2H2C Gene

    395 amino acids
    Molecular mass:
    44452 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GTF2H2C Gene

Proteomics data for GTF2H2C Gene at MOPED

Post-translational modifications for GTF2H2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTF2H2C Gene

Domains & Families for GTF2H2C Gene

Protein Domains for GTF2H2C Gene

Suggested Antigen Peptide Sequences for GTF2H2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 VWFA domain.
  • Belongs to the GTF2H2 family.
  • Contains 1 VWFA domain.
  • Belongs to the GTF2H2 family.
genes like me logo Genes that share domains with GTF2H2C: view

No data available for Gene Families for GTF2H2C Gene

Function for GTF2H2C Gene

Molecular function for GTF2H2C Gene

GENATLAS Biochemistry:
general (basal) transcription factor IIH,p44 subunit in the SMN centromeric cluster
UniProtKB/Swiss-Prot Function:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
genes like me logo Genes that share phenotypes with GTF2H2C: view

Animal Model Products

CRISPR Products

miRNA for GTF2H2C Gene

miRTarBase miRNAs that target GTF2H2C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2H2C Gene

Localization for GTF2H2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2H2C Gene

Subcellular locations from

Jensen Localization Image for GTF2H2C Gene COMPARTMENTS Subcellular localization image for GTF2H2C gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for GTF2H2C Gene

Pathways & Interactions for GTF2H2C Gene

SuperPathways for GTF2H2C Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
5 Infectious disease
genes like me logo Genes that share pathways with GTF2H2C: view

Pathways by source for GTF2H2C Gene

Gene Ontology (GO) - Biological Process for GTF2H2C Gene


No data available for SIGNOR curated interactions for GTF2H2C Gene

Drugs & Compounds for GTF2H2C Gene

No Compound Related Data Available

Transcripts for GTF2H2C Gene

mRNA/cDNA for GTF2H2C Gene

(17) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GTF2H2C Gene

General transcription factor IIH, polypeptide 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2H2C Gene

No ASD Table

Relevant External Links for GTF2H2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTF2H2C Gene

mRNA expression in normal human tissues for GTF2H2C Gene

Protein differential expression in normal tissues from HIPED for GTF2H2C Gene

This gene is overexpressed in Lung (26.6), Breast (22.3), and Liver (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2H2C Gene

SOURCE GeneReport for Unigene cluster for GTF2H2C Gene Hs.191356

genes like me logo Genes that share expression patterns with GTF2H2C: view

Protein tissue co-expression partners for GTF2H2C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2H2C Gene

Orthologs for GTF2H2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2H2C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GTF2H2 36
  • 97 (a)
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
-- 36
  • 94 (a)
(Mus musculus)
Mammalia Gtf2h2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
(Pan troglodytes)
Mammalia GTF2H2 36
  • 99 (a)
(Gallus gallus)
Aves -- 36
  • 87 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
(Danio rerio)
Actinopterygii gtf2h2 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ssl1 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea T16H12.4 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSL1 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for GTF2H2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GTF2H2C Gene

Gene Tree for GTF2H2C (if available)
Gene Tree for GTF2H2C (if available)

Paralogs for GTF2H2C Gene

Paralogs for GTF2H2C Gene

(2) SIMAP similar genes for GTF2H2C Gene using alignment to 8 proteins: Pseudogenes for GTF2H2C Gene

genes like me logo Genes that share paralogs with GTF2H2C: view

Variants for GTF2H2C Gene

Sequence variations from dbSNP and Humsavar for GTF2H2C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2666616 -- 69,573,638(-) TATCA(A/G)TTAGT intron-variant
rs2666617 -- 69,573,196(+) aaaaa(A/T)aTATA intron-variant
rs3097196 -- 69,561,934(+) TTCTT(A/C/G)GCAGG intron-variant, upstream-variant-2KB
rs3106290 -- 69,580,808(-) GTTTG(C/T)ATTAC intron-variant
rs473480 -- 69,584,939(-) gacgg(A/C)ttctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2H2C Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396
nsv881768 CNV Loss 21882294
nsv428117 CNV Gain+Loss 18775914
dgv6086n71 CNV Gain 21882294
nsv10707 CNV Gain+Loss 18304495
nsv881770 CNV Gain 21882294
nsv881771 CNV Loss 21882294
esv2669461 CNV Deletion 23128226
esv32846 CNV Loss 17666407
esv22113 CNV Gain+Loss 19812545
esv1009388 CNV Gain 20482838
nsv471498 CNV Duplication 19718026
nsv881772 CNV Gain 21882294
nsv433371 CNV Gain 18776910

Variation tolerance for GTF2H2C Gene

Gene Damage Index Score: 0.95; 19.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GTF2H2C Gene

Disorders for GTF2H2C Gene

Relevant External Links for GTF2H2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GTF2H2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2H2C Gene

Publications for GTF2H2C Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3

Products for GTF2H2C Gene

Sources for GTF2H2C Gene