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Aliases for GTF2H2C Gene

Aliases for GTF2H2C Gene

  • GTF2H2 Family Member C 2 3
  • General Transcription Factor IIH Polypeptide 2-Like Protein 3 4
  • General Transcription Factor IIH, Polypeptide 2C 2 3
  • GTF2H2C GTF2H2C_2 4
  • GTF2H2C_2 3
  • GTF2H2D 4

External Ids for GTF2H2C Gene

Previous GeneCards Identifiers for GTF2H2C Gene

  • GC05P068897
  • GC05P068762
  • GC05P068856

Summaries for GTF2H2C Gene

GeneCards Summary for GTF2H2C Gene

GTF2H2C (GTF2H2 Family Member C) is a Protein Coding gene. Among its related pathways are Infectious disease and Gene Expression. An important paralog of this gene is GTF2H2.

UniProtKB/Swiss-Prot for GTF2H2C Gene

  • Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2H2C Gene

Genomics for GTF2H2C Gene

Regulatory Elements for GTF2H2C Gene

Genomic Location for GTF2H2C Gene

Chromosome:
5
Start:
69,560,143 bp from pter
End:
69,594,723 bp from pter
Size:
34,581 bases
Orientation:
Plus strand

Genomic View for GTF2H2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2H2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2H2C Gene

Proteins for GTF2H2C Gene

  • Protein details for GTF2H2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1K8-T2H2L_HUMAN
    Recommended name:
    General transcription factor IIH subunit 2-like protein
    Protein Accession:
    Q6P1K8
    Secondary Accessions:
    • A6NED9
    • A8K8J6
    • B2RCU4
    • B7ZW39

    Protein attributes for GTF2H2C Gene

    Size:
    395 amino acids
    Molecular mass:
    44452 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GTF2H2C Gene

Proteomics data for GTF2H2C Gene at MOPED

Post-translational modifications for GTF2H2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTF2H2C Gene

Domains & Families for GTF2H2C Gene

Protein Domains for GTF2H2C Gene

Suggested Antigen Peptide Sequences for GTF2H2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1K8

UniProtKB/Swiss-Prot:

T2H2L_HUMAN :
  • Contains 1 VWFA domain.
  • Belongs to the GTF2H2 family.
Domain:
  • Contains 1 VWFA domain.
Family:
  • Belongs to the GTF2H2 family.
genes like me logo Genes that share domains with GTF2H2C: view

No data available for Gene Families for GTF2H2C Gene

Function for GTF2H2C Gene

Molecular function for GTF2H2C Gene

GENATLAS Biochemistry:
general (basal) transcription factor IIH,p44 subunit in the SMN centromeric cluster
UniProtKB/Swiss-Prot Function:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

Gene Ontology (GO) - Molecular Function for GTF2H2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with GTF2H2C: view

Phenotypes for GTF2H2C Gene

GenomeRNAi human phenotypes for GTF2H2C:
genes like me logo Genes that share phenotypes with GTF2H2C: view

Animal Model Products

CRISPR Products

miRNA for GTF2H2C Gene

miRTarBase miRNAs that target GTF2H2C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2H2C Gene

Localization for GTF2H2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2H2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2H2C Gene COMPARTMENTS Subcellular localization image for GTF2H2C gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for GTF2H2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000439 core TFIIH complex IEA --
genes like me logo Genes that share ontologies with GTF2H2C: view

Pathways & Interactions for GTF2H2C Gene

SuperPathways for GTF2H2C Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 RNA Polymerase I Transcription
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Infectious disease
.53
genes like me logo Genes that share pathways with GTF2H2C: view

Gene Ontology (GO) - Biological Process for GTF2H2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair --
GO:0006289 nucleotide-excision repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GTF2H2C: view

No data available for SIGNOR curated interactions for GTF2H2C Gene

Drugs & Compounds for GTF2H2C Gene

No Compound Related Data Available

Transcripts for GTF2H2C Gene

mRNA/cDNA for GTF2H2C Gene

(17) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GTF2H2C Gene

General transcription factor IIH, polypeptide 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2H2C Gene

No ASD Table

Relevant External Links for GTF2H2C Gene

GeneLoc Exon Structure for
GTF2H2C
ECgene alternative splicing isoforms for
GTF2H2C

Expression for GTF2H2C Gene

mRNA expression in normal human tissues for GTF2H2C Gene

Protein differential expression in normal tissues from HIPED for GTF2H2C Gene

This gene is overexpressed in Lung (26.6), Breast (22.3), and Liver (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2H2C Gene



SOURCE GeneReport for Unigene cluster for GTF2H2C Gene Hs.191356

genes like me logo Genes that share expression patterns with GTF2H2C: view

Protein tissue co-expression partners for GTF2H2C Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2H2C Gene

Orthologs for GTF2H2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2H2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2H2 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gtf2h2 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GTF2H2 36
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gtf2h2 36
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ssl1 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T16H12.4 36
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSL1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for GTF2H2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GTF2H2C Gene

ENSEMBL:
Gene Tree for GTF2H2C (if available)
TreeFam:
Gene Tree for GTF2H2C (if available)

Paralogs for GTF2H2C Gene

Paralogs for GTF2H2C Gene

(2) SIMAP similar genes for GTF2H2C Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for GTF2H2C Gene

genes like me logo Genes that share paralogs with GTF2H2C: view

Variants for GTF2H2C Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF2H2C Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396
nsv881768 CNV Loss 21882294
nsv428117 CNV Gain+Loss 18775914
dgv6086n71 CNV Gain 21882294
nsv10707 CNV Gain+Loss 18304495
nsv881770 CNV Gain 21882294
nsv881771 CNV Loss 21882294
esv2669461 CNV Deletion 23128226
esv32846 CNV Loss 17666407
esv22113 CNV Gain+Loss 19812545
esv1009388 CNV Gain 20482838
nsv471498 CNV Duplication 19718026
nsv881772 CNV Gain 21882294
nsv433371 CNV Gain 18776910

Variation tolerance for GTF2H2C Gene

Gene Damage Index Score: 0.95; 19.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2H2C Gene

HapMap Linkage Disequilibrium report
GTF2H2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GTF2H2C Gene

Disorders for GTF2H2C Gene

Relevant External Links for GTF2H2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2H2C
genes like me logo Genes that share disorders with GTF2H2C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2H2C Gene

Publications for GTF2H2C Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for GTF2H2C Gene

Sources for GTF2H2C Gene

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