V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

GTF2H2 Gene

protein-coding GIFtS: 60

GC05M070366

general transcription factor IIH, polypeptide 2, 44kDa
(Previous names: general transcription factor IIH, polypeptide 2 (44kD subunit) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BTF2 ^¹, ²
BTF2-p44 ^³
BTF2P44 ^¹, ², ³
MGC102806 ^²
T-BTF2P44 ^¹, ²
TFIIH ^¹, ²

Descriptions
Basic transcription factor 2 44 kDa subunit ^³
General transcription factor IIH polypeptide 2 ^³
TFIIH basal transcription factor complex p44 subunit ^³
general transcription factor IIH, polypeptide 2 (44kD subunit) ^¹, ²
general transcription factor IIH, polypeptide 2, 44kD subunit ^²
general transcription factor IIH, polypeptide 2, 44kDa ^²

External Ids
HGNC: 4656¹
Entrez Gene: 2966²
UniProtKB: Q13888³
Ensembl: ENSG00000145736⁷

Search outside databases for aliases for GTF2H2 gene

Previous GC identifers: GC05P069008 GC05P070422 GC05P068962

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GTF2H2:

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region

contains at least four genes and repetitive elements which make it prone to rearrangements and

deletions. The repetitiveness and complexity of the sequence have also caused difficulty in

determining the organization of this genomic region. This gene is within the telomeric copy of the

duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in

spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to

the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription

initiation factor IIH which is involved in basal transcription and nucleotide excision repair.

Transcript variants for this gene have been described, but their full length nature has not been

determined. A second copy of this gene within the centromeric copy of the duplication has been

described in the literature. It is reported to be different by either two or four base pairs;

however, no sequence data is currently available for the centromeric copy of the gene. [provided

by RefSeq]

UniProtKB/Swiss-Prot: TF2H2_HUMAN, Q13888

Function: Component of the core-TFIIH basal transcription factor involved in nucleotide excision

repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The

N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a

successful escape of RNAP II form the promoter

Gene Wiki entry for GTF2H2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GTF2H2 gene

Entrez Gene cytogenetic band: 5q12.2-q13.3 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13.2

GTF2H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M070366: (about GC identifiers)

Start:	70,366,707 bp from pter
End:	70,399,253 bp from pter
Size:	32,547 bases
Orientation:	minus strand

1 alternative location:

Chr5+,c5_H2 69,315,938-69,348,477

RefSeq DNA sequence:

NC_000005.8 NT_006713.14 NT_113801.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TF2H2_HUMAN, Q13888 (See protein sequence)

Recommended Name: General transcription factor IIH subunit 2

Size: 395 amino acids; 44419 Da

Subunit: One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with

XPB, XPD, GTF2H1 and GTF2H3

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1Z60 (3D)

Secondary accessions: Q15570 Q15571 Q9BS41

Alternative splicing: 1 isoform: Q13888-1 (A number of isoforms may be produced. The isoforms may be also produced by incomplete gene duplication)

REFSEQ proteins: NP_001506.1

ENSEMBL proteins:

ENSP00000328901 ENSP00000274400

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GTF2H2 )
	Human Recombinant Proteins from Abnova (GTF2H2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	1939271 2449431 8946909 9512541 9582279 9790902 10214908 11313499 12393749 12646563

About this table

Antibodies for GTF2H2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GTF2H2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GTF2H2 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GTF2H2)
	Novus Biologicals Antibody for GTF2H2

Assays for GTF2H2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13888

ProtoNet protein and cluster: Q13888

2 Blocks protein families:

IPB001841 Zn-finger

IPB007198 Ssl1-like

UniProtKB/Swiss-Prot: TF2H2_HUMAN, Q13888

Similarity: Belongs to the GTF2H2 family

Similarity: Contains 1 VWFA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GTF2H2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GTF2H2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001515

Applied Biosystems Silencer® siRNAs for GTF2H2

Sigma-Aldrich siRNA for GTF2H2

Sigma-Aldrich shRNA Panels and shRNA for GTF2H2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GTF2H2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001515
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001515
untagged cDNA clones in CMV expression vector (see all 3): NM_001515

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001515

UniProtKB/Swiss-Prot: TF2H2_HUMAN, Q13888

Function: Component of the core-TFIIH basal transcription factor involved in nucleotide excision

repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The

N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a

successful escape of RNAP II form the promoter

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	8194529
GO:0008135	translation factor activity, nucleic acid binding	TAS	8194529
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0047485	protein N-terminus binding	IPI	8652557

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for GTF2H2 (Your Favorite Gene powered by Ingenuity)

Nucleotide Excision Repair Pathway
Estrogen Receptor Signaling
Androgen Signaling
RAR Activation
Glucocorticoid Receptor Signaling

GeneDecks GTF2H2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GTF2H2

2 Interacting proteins for GTF2H2 (ENSP00000274400³ Q13888¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERCC8	Q13216-1¹	EBI-1565170, EBI-596556
NR1H2	ENSP00000253727³	STRING (score=.72)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000718	nucleotide-excision repair, DNA damage removal	EXP	10583946
GO:0006281	DNA repair	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	EXP	8946909
GO:0006368	RNA elongation from RNA polymerase II promoter	EXP	9405375

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GTF2H2
2 Novoseek chemical compound relationships for GTF2H2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	4.48	2	8194529 (1), 10882739 (1)
atp	0.00	2	11141066 (1), 11089979 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GTF2H2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GTF2H2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001515

Sigma-Aldrich siRNA for GTF2H2

Sigma-Aldrich shRNA Panels and shRNA for GTF2H2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001515

REFSEQ mRNAs for GTF2H2 gene:

NM_001515.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001515

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001515
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001515
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001515

Additional cDNA sequence:

AF078847.1 AF086359.1 AK296578.1 BC005345.1 BT006773.1 BX537982.1 BX647532.1 DQ786268.1

U21910.1 U21915.1 Z30094.1

24/31 DOTS entries (see all 31 ):

DT.102840497 DT.95199285 DT.120845171 DT.413008 DT.120845156 DT.429771 DT.100822315 DT.100822322

DT.120845041 DT.214322 DT.75143754 DT.100026778 DT.120845251 DT.427316 DT.91719169 DT.100822319

DT.100822320 DT.100822324 DT.100822329 DT.100822331 DT.120845005 DT.97844340 DT.100730076 DT.100822316

24/273 AceView cDNA sequences (see all 273 ):

AA989156 BQ918368 BM768623 AA677890 AI056697 AA678043 AA829390 AW592525

BM462360 BQ030091 BG169070 AI205195 BX279649 W76286 CF541411 AA306816

AI159978 AI472627 AA639150 AA449941 AA716448 AA353355 N72406 AA293389

highest scoring ESTs for GTF2H2:

CN273403 AA203547 AI434311 AI933976 AK093949 AK123868 AL711387 AX748379 BE967510 BF802059

Unigene Cluster for GTF2H2:

General transcription factor IIH, polypeptide 2, 44kDa

Hs.655216 [show with all ESTs]

Unigene Representative Sequence: BX647532

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2H2 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16
SP1:																																			-						-
SP2:																									-
SP3:															-
SP4:
SP5:																							-		-

About this scheme

ECgene alternative splicing isoforms for GTF2H2

2 Ensembl transcripts including schematic representations:

ENST00000330280 ENST00000274400

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GTF2H2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GTF2H2

¹ / ² / ³

8 probe-sets matching GTF2H2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89507_at²^{, 3}	U95-E	4	1.00	0.25	1.00	1.00	AA374597	0.60	0.54	0.57	1
33715_r_at²^{, 3}	U95-A	4	1.00	0.25	0.63	0.41	U80017	0.20	0.14	0.17	1
223758_s_at²^{, 3}	U133-B	4	1.00	0.26	--	--	BC005345	0.60	0.58	0.59	1
221540_x_at²^{, 3}	U133-A	4	0.82	0.25	--	--	AF078847	0.60	0.42	0.52	1
239735_at*²	U133-B	17	0.27	0.06	--	--	--	--	--	--	--
223758_s_at²	U133Plus2	4	1.00	0.26	--	--	--	--	--	--	--
221540_x_at²	U133Plus2	4	0.82	0.25	--	--	--	--	--	--	--
239735_at*²	U133Plus2	17	0.27	0.06	--	--	--	--	--	--	--

GeneDecks GTF2H2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.655216
UniProtKB/Swiss-Prot: TF2H2_HUMAN, Q13888
Tissue specificity: Widely expressed, with higher expression in skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GTF2H2 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GTF2H2¹	--	general transcription factor IIH, polypeptide 2, 44kDa	91.98(n) 98.23(a)	478089 XM_535266.2 XP_535266.2
chimpanzee (Pan troglodytes)	GTF2H2¹	--	general transcription factor IIH, polypeptide 2, 44kDa	99.24(n) 99.49(a)	461830 XM_001157963.1 XP_001157963.1
cow (Bos taurus)	GTF2H2¹	--	general transcription factor IIH, polypeptide 2, 44kDa	93(n) 97.22(a)	511829 NM_001038530.1 NP_001033619.1
rat (Rattus norvegicus)	Gtf2h2¹	--	general transcription factor IIH, polypeptide 2	88.1(n) 96.71(a)	294693 XM_215466.4 XP_215466.2
mouse (Mus musculus)	Gtf2h2^{1, 5}	13 (55.90 cM)⁵	general transcription factor II H, polypeptide 2^{1, 5}	90.55(n)¹ 96.96(a)¹	23894¹ NM_022011.3¹ NP_071294.2¹ AA183802⁵ AB221674⁵ (see all 22)

About this table Species with no ortholog for GTF2H2

ENSEMBL Gene Tree for GTF2H2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GTF2H2 gene

GTF2H2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/15 NCBI SNPs in GTF2H2 are shown (see all 15 )

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs2666617^1,2	C	70386283(+)	`aaaaaA/TaTATA`	1	--	int¹		0	--	--	--	--
--	rs2576897^1,2	C	70385880(-)	`TGAGAA/CGATAA`	1	--	int¹		0	--	--	--	--
--	rs2457872^1,2	C	70386004(-)	`TAGTCC/TGCCCT`	1	--	int¹		0	--	--	--	--
--	rs2561155^1,2	C	70386097(+)	`acatgA/Gtgaaa`	1	--	int¹		0	--	--	--	--
--	rs72385012^1,2	--	70386304(+)	`GTGTG-/GTTGTGT`	1	--	int¹		0	--	--	--	--
--	rs5868584^1,2	--	70386398(-)	`atata-/TAaagct`	1	--	int¹		0	--	--	--	--
--	rs9763784^1,2	--	70386295(-)	`cacacA/GTATAT`	1	--	int¹		0	--	--	--	--
--	rs5006682^1,2	--	70386336(-)	`ATATAC/TACACA`	1	--	int¹		0	--	--	--	--
--	rs562878^1,2	--	70367937(+)	`CTTCAC/TACACA`	1	--	int¹		0	--	--	--	--
--	rs56381512^1,2	--	70385908(+)	`CTGCTA/CCTGTA`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for GTF2H2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601748

5 Novoseek disease relationships for GTF2H2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
muscular atrophy spinal	79.62	11	17903057 (1), 10673506 (1), 10686493 (1)
werdnig-hoffmann disease	64.87	1	8981949 (1)
cockayne syndrome	62.91	1	8652557 (1)
xeroderma pigmentosum	55.98	1	8652557 (1)
genetic disorder	12.39	1	14550632 (1)

About this table

Human Genome Epidemiology Navigator: GTF2H2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/113 PubMed articles for GTF2H2 gene (see all 113 ):

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. (PubMed id 8194529)^{1, 2, 3, 4} Humbert S....Moncollin V. (1994)
A multicopy transcription-repair gene, BTF2p44, maps to the SMA region and demonstrates SMA associated deletions. (PubMed id 9063743)^{1, 3, 4} Carter T.A.... Gilliam T.C. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A role of the C-terminal part of p44 in the promoter escape activity of transcription factor IIH. (PubMed id 11319235)^{3, 4} Tremeau-Bravard A.... Egly J.-M. (2001)
Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP. (PubMed id 9503025)^{3, 4} Chen Q....MacKenzie A.E. (1998)
A provisional transcript map of the spinal muscular atrophy (SMA) critical region. (PubMed id 7552146)^{3, 4} van der Steege G.... Buys C.H.C.M. (1995)
Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. (PubMed id 9130708)^{1, 3} Rossignol M....Egly J.M. (1997)
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. (PubMed id 8652557)^{1, 3} Iyer N....Friedberg E.C. (1996)
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. (PubMed id 8692841)^{1, 3} Reardon J.T....Pan Z.Q. (1996)
The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease. (PubMed id 8981949)^{1, 3} Burglen L....Melki J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2966	HGNC: 4656	AceView: GTF2H2.2	Ensembl:ENSG00000145736	euGenes: HUgn2966
ECgene: GTF2H2	H-InvDB: GTF2H2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GTF2H2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GTF2H2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GTF2H2:

TaqMan ® Gene Expression Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GTF2H2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GTF2H2		Antibodies for GTF2H2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GTF2H2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GTF2H2)
	Antibodies (GTF2H2)
	Chimera RNAi (GTF2H2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (GTF2H2 )
	Antibodies (GTF2H2 )

Search OriGene for GTF2H2

Search Tocris compounds for GTF2H2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GTF2H2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GTF2H2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

GTF2H2 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for GTF2H2

Summaries
for GTF2H2

Genomic Location
for GTF2H2

Proteins
for GTF2H2

Protein Domains/
Families
for GTF2H2

Gene Function
for GTF2H2

Pathways & Interactions
for GTF2H2

Drugs & Compounds
for GTF2H2

Transcripts
for GTF2H2

Expression
for GTF2H2

Orthologs
for GTF2H2

Paralogs
for GTF2H2

SNPs/Variants
for GTF2H2

Disorders & Mutations
for GTF2H2

Medical News
for GTF2H2

Publications
for GTF2H2

Search for GTF2H2

Genome Databases showing GTF2H2

Other Databases showing GTF2H2

Specialized Databases showing GTF2H2

Licensable Technologies
for GTF2H2

Services
for GTF2H2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GTF2H2 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor GTF2H2

Summariesfor GTF2H2

Genomic Locationfor GTF2H2

Proteinsfor GTF2H2

Protein Domains/Familiesfor GTF2H2

Gene Functionfor GTF2H2

Pathways & Interactionsfor GTF2H2

Drugs & Compoundsfor GTF2H2

Transcriptsfor GTF2H2

Expression for GTF2H2

Orthologsfor GTF2H2

Paralogsfor GTF2H2

SNPs/Variantsfor GTF2H2

Disorders & Mutationsfor GTF2H2

Medical Newsfor GTF2H2

Publicationsfor GTF2H2

Search for GTF2H2

Genome Databases showing GTF2H2

Other Databases showing GTF2H2

Specialized Databases showing GTF2H2

Licensable Technologiesfor GTF2H2

Servicesfor GTF2H2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GTF2H2

Summaries
for GTF2H2

Genomic Location
for GTF2H2

Proteins
for GTF2H2

Protein Domains/
Families
for GTF2H2

Gene Function
for GTF2H2

Pathways & Interactions
for GTF2H2

Drugs & Compounds
for GTF2H2

Transcripts
for GTF2H2

Expression
for GTF2H2

Orthologs
for GTF2H2

Paralogs
for GTF2H2

SNPs/Variants
for GTF2H2

Disorders & Mutations
for GTF2H2

Medical News
for GTF2H2

Publications
for GTF2H2

Licensable Technologies
for GTF2H2

Services
for GTF2H2