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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GTF2F2 Gene

protein-coding   GIFtS: 62
GCID: GC13P045694

general transcription factor IIF, polypeptide 2, 30kDa

(Previous names: general transcription factor IIF, polypeptide 1 (74kD subunit)...)
 Explore 7 diseases affiliated with
GTF2F2 via our new
 Human Malady Compendium 
Biological research products
for GTF2F2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
General Transcription Factor IIF, Polypeptide 2, 30kDa1 2     TFIIF-Beta1
RAP301 2 3     ATP-Dependent Helicase GTF2F22 3
BTF41 2     General Transcription Factor IIF, Polypeptide 1 (74kD Subunit)1
TFIIF1 2     TF2F22
General Transcription Factor IIF 30 KDa Subunit2 3     General Transcription Factor IIF Subunit 22
Transcription Initiation Factor IIF Subunit Beta2 3     EC 3.6.4.123
Transcription Initiation Factor RAP302 3     EC 3.6.18

External Ids:    HGNC: 46531   Entrez Gene: 29632   Ensembl: ENSG000001883427   OMIM: 1899695   UniProtKB: P139843   

Export aliases for GTF2F2 gene to outside databases

Previous GC identifers: GC13P043694 GC13P039681 GC13P044631 GC13P043492 GC13P044592 GC13P026496


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984
Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to
the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows
ATP-dependent DNA-helicase activity

Gene Wiki entry for GTF2F2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTF2F2 gene promoter:
         CHOP-10   Egr-2   POU2F1   POU2F1a   MyoD   POU6F1 (c2)   POU3F2   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GTF2F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.12   HGNC cytogenetic band: 13q14

GTF2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2F2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P045694:  view genomic region     (about GC identifiers)

Start:
45,694,631 bp from pter      End:
45,858,240 bp from pter
Size:
163,610 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984 (See protein sequence)
Recommended Name: General transcription factor IIF subunit 2  
Size: 249 amino acids; 28380 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with
URI1
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for GTF2F2:
1BBY (3D)        1F3U (3D)        2BBY (3D)    
Secondary accessions: A6NNS5 Q5W0H3

Explore the universe of human proteins at neXtProt for GTF2F2: NX_P13984

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13984

  • 4/8 DME Specific Peptides for GTF2F2 (P13984) (see all 8)
     GAKQNTG  QIEESSKP  AFEKHQYYN  NHQYNIEYE 

    GTF2F2 Protein expression data from MOPED and PaxDb:    About this image 
    GTF2F2 Protein Expression
    REFSEQ proteins: NP_004119.1  
    ENSEMBL proteins: 
     ENSP00000340823  
    Reactome Protein details: P13984
    Human Recombinant Protein Products for GTF2F2: 
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    Novus Biologicals GTF2F2 Proteins
    Novus Biologicals GTF2F2 Lysates
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    ProSpec Recombinant Protein for GTF2F2
    Uscn Proteins for GTF2F2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005674transcription factor TFIIF complex IEA--
    GO:0015630microtubule cytoskeleton IDA--

    GTF2F2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GTF2F2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR003196 TFIIF_beta
     IPR016640 TFIIF-beta_subgr
     IPR011039 TFIIF_interaction

    Graphical View of Domain Structure for InterPro Entry P13984

    ProtoNet protein and cluster: P13984

    1 Blocks protein family: IPB003196 Transcription initiation factor IIF

    UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984
    Similarity: Belongs to the TFIIF beta subunit family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2FB_HUMAN, P13984
    Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to
    the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows
    ATP-dependent DNA-helicase activity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for GTF2F2:
    general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across DNA
    templates

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003702RNA polymerase II transcription factor activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    GTF2F2 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2F2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/30 pathways (see all 30)
    RNA Polymerase II Transcription Elongation1.00
    mRNA Capping0.59
    Formation of HIV-1 elongation complex in the absence of HIV-1 Tat1.00
    Abortive elongation of HIV-1 transcript in the absence of Tat0.55
    Formation of RNA Pol II elongation complex 1.00
    RNA Pol II CTD phosphorylation and interaction with CE0.55
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.98
    RNA Pol II CTD phosphorylation and interaction with CE0.55
    2mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    mRNA Processing0.82
    mRNA Splicing - Major Pathway1.00
    mRNA Splicing - Minor Pathway0.40
    Processing of Capped Intron-Containing Pre-mRNA0.96
    3Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex1.00
    Protein Acetylation and Deacetylation0.51
    Transcription of mRNA0.91
    Basal transcription factors0.49
    4HIV Infection
    HIV Infection1.00
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    5Late Phase of HIV Life Cycle
    Late Phase of HIV Life Cycle1.00
    HIV Life Cycle0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GTF2F2
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF2F2 (see all 6)
        Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Transcription of mRNA

    1 GeneGo (Thomson Reuters) Pathway for GTF2F2
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for GTF2F2 
        Eukaryotic Transcription Initiation

    5/41        Reactome Pathways for GTF2F2 (see all 41)
        Tat-mediated HIV-1 elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    mRNA Splicing
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Addition of the fourth nucleotide on the Nascent Transcript: Second Transition


    1         Kegg Pathway  (Kegg details for GTF2F2):
        Basal transcription factors


    GTF2F2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF2F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/179 Interacting proteins for GTF2F2 (P139841, 2, 3 ENSP000003408234) via UniProtKB, MINT, STRING, and/or I2D (see all 179)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    URI1O947631, 3, ENSP000003760974EBI-1030560,EBI-2683009 I2D: score=3 STRING: ENSP00000376097
    RPL27AP467761, 3EBI-1030560,EBI-350581 I2D: score=1 
    TCTEX1D2Q8WW351, 3EBI-1030560,EBI-2692044 I2D: score=1 
    GTF2BQ004032, 3, ENSP000003595314MINT-2982956 I2D: score=4 STRING: ENSP00000359531
    AHRP358693, ENSP000002420574I2D: score=3 STRING: ENSP00000242057
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    GTF2F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GTF2F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTF2F2
    3 Novoseek chemical compound relationships for GTF2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphodiester 53.5 2 10872452 (1), 8631733 (1)
    alanine 16.2 1 16169872 (1)
    atp 11.9 2 7982911 (1), 8631733 (1)

    Search CenterWatch for drugs/clinical trials and news about GTF2F2 / T2FB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GTF2F2 gene: 
    NM_004128.2  

    Unigene Cluster for GTF2F2:

    General transcription factor IIF, polypeptide 2, 30kDa
    Hs.654582  [show with all ESTs]
    Unigene Representative Sequence: NM_004128
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340473(uc001uzw.3) ENST00000494087 ENST00000461904

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    Additional cDNA sequence: 

    AK291545.1 BC001771.1 BT019525.1 X16901.1 X59745.1 

    7 DOTS entries:

    DT.114042  DT.100796480  DT.100834650  DT.40130785  DT.99997299  DT.120789664  DT.120789671 

    24/152 AceView cDNA sequences (see all 152):

    CR598374 CB126197 BQ422614 BI962979 CB126757 CA444768 CB125610 BU184889 
    CA443379 BF478141 AI803556 BI755137 BQ416648 BP369463 BI755136 AI886116 
    AA831445 BM549442 CB125216 N73082 CB124466 BE906625 BX089414 CA868274 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                    -     -           -     -                                 
    SP2:                    -     -           -     -                                 
    SP3:                          -           -     -                                 
    SP4:                                                                              
    SP5:                                      -     -                                 


    ECgene alternative splicing isoforms for GTF2F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GTF2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAGTGAAAC
    GTF2F2 Expression
    About this image
    See GTF2F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GTF2F2

    SOURCE GeneReport for Unigene cluster: Hs.654582
        SABiosciences Custom PCR Arrays for GTF2F2

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GTF2F2 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2f21 , 5 general transcription factor IIF, polypeptide 21, 5 90.09(n)1
    97.99(a)1
      14 (40.29 cM)5
    687051  NM_026816.31  NP_081092.11 
     758969375 
    chicken
    (Gallus gallus)
    Aves GTF2F21 general transcription factor IIF, polypeptide 2, 3 more 81.26(n)
    89.56(a)
      418843  XM_417039.3  XP_417039.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983332 transcription factor RAP30 75.73(n)    Z15132.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb39a052 Transcribed sequence with moderate similarity to protein more 74.9(n)    CF999714.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIF&bgr;3
    TfIIFbeta1
    transcription initiation from Pol II
    promoter more3
    Transcription factor TFIIFbeta1
    46(a)3
    54.89(n)1
    53.19(a)1
      3 86C63
    412901  NM_079581.31  NP_524305.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39B6A.363
    CELE_Y39B6A.361
    Protein Y39B6A.361 34(a)3
    49.72(n)1
    37.5(a)1
      V(18990623-18994788)3
    1802431  NM_171571.31  NP_741661.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TFG2(YGR005C)4
    TFG21
    TFIIF (Transcription Factor II) middle subunit; involved more4
    Tfg2p1
    42.32(n)1
    27.63(a)1
      7(505859-504657)4
    8528881, 4  NP_011519.31  NP_011519.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G522706
    AT1G755106
    Transcription initiation factor IIF, beta subunit
    transcription initiation factor TFIIF beta subunit...
    22(a)
    21(a)
    many → 1
    many → 1
    3(19387180-19388944)
    1(28347055-28348735)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    transcription initiation factor IIF beta subunit, ...
    transcription initiation factor IIF beta subunit, ...
    24(a)
    22(a)
    many → 1
    many → 1
    5(25198086-25201147)
    1(32597037-32600766)


    ENSEMBL Gene Tree for GTF2F2 (if available)
    TreeFam Gene Tree for GTF2F2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GTF2F2 gene

    GTF2F2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GTF2F2
    PGOHUM00000243979 PGOHUM00000246098


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2543 NCBI SNPs in GTF2F2 are shown (see all 2543    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852812241,2
    --45692673(+) TTTCCA/GTTCTT 1 -- us2k10--------
    rs1471426601,2
    --45692688(+) AGCCCG/TTTCAT 1 -- us2k10--------
    rs1159113211,2
    F--45692754(+) CACCAC/TGTACA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs768606911,2
    F--45692871(+) TTTCAA/GTTTAT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1165148501,2
    F--45692983(+) TCATTT/ATCTGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1912215591,2
    --45692998(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs1403510111,2
    --45693117(+) GATTAC/TAGGTG 1 -- us2k10--------
    rs1819343271,2
    --45693122(+) CAGGTA/GTGAGC 1 -- us2k10--------
    rs1443260741,2
    --45693166(+) TATTTA/GTTTTT 1 -- us2k10--------
    rs1874366811,2
    --45693221(+) ACGATC/TATGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GTF2F2 (45694631 - 45858240 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GTF2F2: --

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    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF2F2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GTF2F2 for disorders           About GeneDecksing

    OMIM gene information: 189969    OMIM disorders: --

    7 diseases for GTF2F2:    About MalaCards
    intrahepatic cholangiocarcinoma    hepatitis c    cholangiocarcinoma    hepatitis b
    conjunctivitis    hepatitis    immunodeficiency


    Export disorders for GTF2F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GTF2F2 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with GTF2F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PubMed id 12737519)1, 2, 9 Wei W....Murakami S. (2003)
    2. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PubMed id 10454543)1, 2, 9 Kim J.B.... Sharp P.A. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. (PubMed id 9689043)1, 2 Groft C.M.... Werner M.H. (1998)
    5. Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PubMed id 8162052)1, 3 Heng H.H....Tsui L.C. (1994)
    6. Nucleotide and amino acid sequence of RAP30. (PubMed id 1840667)1, 2 Horikoshi M.... Roeder R.G. (1991)
    7. Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II. (PubMed id 2477704)1, 2 Sopta M.... Greenblatt J. (1989)
    8. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PubMed id 16169872)1, 9 Le T.T....Murakami S. (2005)
    9. Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. (PubMed id 8758937)1, 9 Dubrovskaya V....Tora L. (1996)
    10. Structure-function analysis of Msx2-mediated transcriptional suppression. (PubMed id 9265625)1, 9 Newberry E.P....Towler D.A. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2963 HGNC: 4653 AceView: GTF2F2 Ensembl:ENSG00000188342 euGenes: HUgn2963
    ECgene: GTF2F2 Kegg: 2963 H-InvDB: GTF2F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GTF2F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GTF2F2 gene:
    Search GeneIP for patents involving GTF2F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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