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Aliases for GTF2F2 Gene

Aliases for GTF2F2 Gene

  • General Transcription Factor IIF, Polypeptide 2, 30kDa 2 3
  • Transcription Initiation Factor IIF Subunit Beta 3 4
  • General Transcription Factor IIF 30 KDa Subunit 3 4
  • Transcription Initiation Factor RAP30 3 4
  • ATP-Dependent Helicase GTF2F2 3 4
  • TFIIF-Beta 3 4
  • RAP30 3 4
  • General Transcription Factor IIF, Polypeptide 1 (74kD Subunit) 2
  • EC 3.6.4.12 4
  • EC 3.6.1 63
  • TFIIF 3
  • TF2F2 3
  • BTF4 3

External Ids for GTF2F2 Gene

Previous GeneCards Identifiers for GTF2F2 Gene

  • GC13P043694
  • GC13P039681
  • GC13P044631
  • GC13P043492
  • GC13P044592
  • GC13P045694
  • GC13P026496

Summaries for GTF2F2 Gene

GeneCards Summary for GTF2F2 Gene

GTF2F2 (General Transcription Factor IIF, Polypeptide 2, 30kDa) is a Protein Coding gene. Among its related pathways are Infectious disease and GPCR Pathway. GO annotations related to this gene include helicase activity and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for GTF2F2 Gene

  • TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Gene Wiki entry for GTF2F2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2F2 Gene

Genomics for GTF2F2 Gene

Regulatory Elements for GTF2F2 Gene

Genomic Location for GTF2F2 Gene

Chromosome:
13
Start:
45,120,464 bp from pter
End:
45,284,909 bp from pter
Size:
164,446 bases
Orientation:
Plus strand

Genomic View for GTF2F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2F2 Gene

Proteins for GTF2F2 Gene

  • Protein details for GTF2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13984-T2FB_HUMAN
    Recommended name:
    General transcription factor IIF subunit 2
    Protein Accession:
    P13984
    Secondary Accessions:
    • A6NNS5
    • Q5W0H3

    Protein attributes for GTF2F2 Gene

    Size:
    249 amino acids
    Molecular mass:
    28380 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1.

    Three dimensional structures from OCA and Proteopedia for GTF2F2 Gene

neXtProt entry for GTF2F2 Gene

Proteomics data for GTF2F2 Gene at MOPED

Selected DME Specific Peptides for GTF2F2 Gene

Post-translational modifications for GTF2F2 Gene

  • Ubiquitination at Lys 137, Lys 147, Lys 154, and Lys 200
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GTF2F2 Gene

Gene Families for GTF2F2 Gene

Protein Domains for GTF2F2 Gene

Suggested Antigen Peptide Sequences for GTF2F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13984

UniProtKB/Swiss-Prot:

T2FB_HUMAN :
  • Belongs to the TFIIF beta subunit family.
Family:
  • Belongs to the TFIIF beta subunit family.
genes like me logo Genes that share domains with GTF2F2: view

Function for GTF2F2 Gene

Molecular function for GTF2F2 Gene

GENATLAS Biochemistry:
general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across DNA templates
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Enzyme Numbers (IUBMB) for GTF2F2 Gene

Gene Ontology (GO) - Molecular Function for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000991 transcription factor activity, core RNA polymerase II binding IBA --
GO:0003677 DNA binding IEA --
GO:0003824 catalytic activity --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 12737519
genes like me logo Genes that share ontologies with GTF2F2: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTF2F2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2F2 Gene

Localization for GTF2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2F2 Gene COMPARTMENTS Subcellular localization image for GTF2F2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16791210
GO:0005654 nucleoplasm TAS --
GO:0005674 transcription factor TFIIF complex IBA --
GO:0005675 holo TFIIH complex IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with GTF2F2: view

Pathways & Interactions for GTF2F2 Gene

SuperPathways for GTF2F2 Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Splicing - Major Pathway
4 Infectious disease
.53
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with GTF2F2: view

Gene Ontology (GO) - Biological Process for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
genes like me logo Genes that share ontologies with GTF2F2: view

No data available for SIGNOR curated interactions for GTF2F2 Gene

Drugs & Compounds for GTF2F2 Gene

(3) Drugs for GTF2F2 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ATP Pharma Activator 0
alanine Nutra 97

(4) Additional Compounds for GTF2F2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Phosphodiester
genes like me logo Genes that share compounds with GTF2F2: view

Transcripts for GTF2F2 Gene

mRNA/cDNA for GTF2F2 Gene

Unigene Clusters for GTF2F2 Gene

General transcription factor IIF, polypeptide 2, 30kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTF2F2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for GTF2F2 Gene

GeneLoc Exon Structure for
GTF2F2
ECgene alternative splicing isoforms for
GTF2F2

Expression for GTF2F2 Gene

mRNA expression in normal human tissues for GTF2F2 Gene

Protein differential expression in normal tissues from HIPED for GTF2F2 Gene

This gene is overexpressed in Fetal testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2F2 Gene



SOURCE GeneReport for Unigene cluster for GTF2F2 Gene Hs.654582

genes like me logo Genes that share expression patterns with GTF2F2: view

Protein tissue co-expression partners for GTF2F2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2F2 Gene

Orthologs for GTF2F2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2F2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2F2 35
  • 92.1 (n)
  • 97.59 (a)
GTF2F2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2F2 35
  • 93.71 (n)
  • 97.99 (a)
-- 36
  • 95 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gtf2f2 35
  • 90.09 (n)
  • 97.99 (a)
Gtf2f2 16
Gtf2f2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF2F2 35
  • 99.46 (n)
  • 100 (a)
GTF2F2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2f2 35
  • 90.5 (n)
  • 97.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2F2 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2F2 35
  • 81.26 (n)
  • 89.56 (a)
GTF2F2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2F2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2f2 35
  • 75.81 (n)
  • 83.47 (a)
MGC75790 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398333 35
zebrafish
(Danio rerio)
Actinopterygii gtf2f2a 35
  • 73.23 (n)
  • 79.92 (a)
wufb39a05 35
gtf2f2a 36
  • 75 (a)
OneToMany
gtf2f2b 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6892 35
fruit fly
(Drosophila melanogaster)
Insecta TfIIFbgr 37
  • 46 (a)
TfIIFbeta 35
  • 55.32 (n)
  • 53.62 (a)
TfIIFbeta 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007002 35
  • 54.04 (n)
  • 54.04 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39B6A.36 37
  • 34 (a)
CELE_Y39B6A.36 35
  • 49.38 (n)
  • 37.34 (a)
Y39B6A.36 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFG2 36
  • 16 (a)
OneToOne
TFG2 38
Species with no ortholog for GTF2F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2F2 Gene

ENSEMBL:
Gene Tree for GTF2F2 (if available)
TreeFam:
Gene Tree for GTF2F2 (if available)

Paralogs for GTF2F2 Gene

Pseudogenes.org Pseudogenes for GTF2F2 Gene

genes like me logo Genes that share paralogs with GTF2F2: view

No data available for Paralogs for GTF2F2 Gene

Variants for GTF2F2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF2F2 Gene

Variant ID Type Subtype PubMed ID
dgv1578n71 CNV Gain 21882294
nsv832596 CNV Loss 17160897
esv2656529 CNV Deletion 23128226
esv2660215 CNV Deletion 23128226
nsv518593 CNV Loss 19592680

Variation tolerance for GTF2F2 Gene

Residual Variation Intolerance Score: 53.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2F2 Gene

HapMap Linkage Disequilibrium report
GTF2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GTF2F2 Gene

Disorders for GTF2F2 Gene

Relevant External Links for GTF2F2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2F2
genes like me logo Genes that share disorders with GTF2F2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2F2 Gene

Publications for GTF2F2 Gene

  1. Position of the general transcription factor TFIIF within the RNA polymerase II transcription preinitiation complex. (PMID: 20033062) Eichner J. … Hahn S. (EMBO J. 2010) 23 67
  2. Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB. (PMID: 19590095) Thompson N.E. … Burgess R.R. (J. Biol. Chem. 2009) 23 67
  3. Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription. (PMID: 17848138) Cojocaru M. … Coulombe B. (Biochem. J. 2008) 23 67
  4. RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. (PMID: 17110932) Charlet-Berguerand N. … Egly J.M. (EMBO J. 2006) 23 67
  5. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PMID: 16169872) Le T.T. … Murakami S. (J. Biochem. 2005) 23 67

Products for GTF2F2 Gene

Sources for GTF2F2 Gene

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