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Aliases for GTF2F2 Gene

Aliases for GTF2F2 Gene

  • General Transcription Factor IIF Subunit 2 2 3 5
  • General Transcription Factor IIF, Polypeptide 2, 30kDa 2 3
  • Transcription Initiation Factor IIF Subunit Beta 3 4
  • General Transcription Factor IIF 30 KDa Subunit 3 4
  • Transcription Initiation Factor RAP30 3 4
  • ATP-Dependent Helicase GTF2F2 3 4
  • TFIIF-Beta 3 4
  • RAP30 3 4
  • General Transcription Factor IIF, Polypeptide 1 (74kD Subunit) 2
  • EC 3.6.4.12 4
  • EC 3.6.1 63
  • TFIIF 3
  • TF2F2 3
  • BTF4 3

External Ids for GTF2F2 Gene

Previous GeneCards Identifiers for GTF2F2 Gene

  • GC13P043694
  • GC13P039681
  • GC13P044631
  • GC13P043492
  • GC13P044592
  • GC13P045694
  • GC13P026496

Summaries for GTF2F2 Gene

GeneCards Summary for GTF2F2 Gene

GTF2F2 (General Transcription Factor IIF Subunit 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include helicase activity and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for GTF2F2 Gene

  • TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Gene Wiki entry for GTF2F2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2F2 Gene

Genomics for GTF2F2 Gene

Regulatory Elements for GTF2F2 Gene

Enhancers for GTF2F2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF2F2 on UCSC Golden Path with GeneCards custom track

Promoters for GTF2F2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF2F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF2F2 Gene

Chromosome:
13
Start:
45,120,464 bp from pter
End:
45,284,909 bp from pter
Size:
164,446 bases
Orientation:
Plus strand

Genomic View for GTF2F2 Gene

Genes around GTF2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2F2 Gene

Proteins for GTF2F2 Gene

  • Protein details for GTF2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13984-T2FB_HUMAN
    Recommended name:
    General transcription factor IIF subunit 2
    Protein Accession:
    P13984
    Secondary Accessions:
    • A6NNS5
    • Q5W0H3

    Protein attributes for GTF2F2 Gene

    Size:
    249 amino acids
    Molecular mass:
    28380 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1.

    Three dimensional structures from OCA and Proteopedia for GTF2F2 Gene

neXtProt entry for GTF2F2 Gene

Proteomics data for GTF2F2 Gene at MOPED

Selected DME Specific Peptides for GTF2F2 Gene

Post-translational modifications for GTF2F2 Gene

  • Ubiquitination at Lys 137, Lys 147, Lys 154, and Lys 200
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GTF2F2 Gene

Gene Families for GTF2F2 Gene

Protein Domains for GTF2F2 Gene

Suggested Antigen Peptide Sequences for GTF2F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13984

UniProtKB/Swiss-Prot:

T2FB_HUMAN :
  • Belongs to the TFIIF beta subunit family.
Family:
  • Belongs to the TFIIF beta subunit family.
genes like me logo Genes that share domains with GTF2F2: view

Function for GTF2F2 Gene

Molecular function for GTF2F2 Gene

GENATLAS Biochemistry:
general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across DNA templates
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Enzyme Numbers (IUBMB) for GTF2F2 Gene

Gene Ontology (GO) - Molecular Function for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GTF2F2: view

Phenotypes for GTF2F2 Gene

GenomeRNAi human phenotypes for GTF2F2:
genes like me logo Genes that share phenotypes with GTF2F2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2F2 Gene

Localization for GTF2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2F2 Gene COMPARTMENTS Subcellular localization image for GTF2F2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for GTF2F2 Gene

Pathways & Interactions for GTF2F2 Gene

SuperPathways for GTF2F2 Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Signaling by FGFR2 in disease
4 mRNA Splicing - Major Pathway
5 Assembly of RNA Polymerase-II Initiation Complex
genes like me logo Genes that share pathways with GTF2F2: view

Gene Ontology (GO) - Biological Process for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA,TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0008380 RNA splicing TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with GTF2F2: view

No data available for SIGNOR curated interactions for GTF2F2 Gene

Drugs & Compounds for GTF2F2 Gene

(3) Drugs for GTF2F2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for GTF2F2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with GTF2F2: view

Transcripts for GTF2F2 Gene

Unigene Clusters for GTF2F2 Gene

General transcription factor IIF, polypeptide 2, 30kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for GTF2F2 Gene

GeneLoc Exon Structure for
GTF2F2
ECgene alternative splicing isoforms for
GTF2F2

Expression for GTF2F2 Gene

mRNA expression in normal human tissues for GTF2F2 Gene

Protein differential expression in normal tissues from HIPED for GTF2F2 Gene

This gene is overexpressed in Fetal testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2F2 Gene



SOURCE GeneReport for Unigene cluster for GTF2F2 Gene Hs.654582

genes like me logo Genes that share expression patterns with GTF2F2: view

Protein tissue co-expression partners for GTF2F2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2F2 Gene

Orthologs for GTF2F2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2F2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2F2 35
  • 92.1 (n)
  • 97.59 (a)
GTF2F2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2F2 35
  • 93.71 (n)
  • 97.99 (a)
-- 36
  • 95 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gtf2f2 35
  • 90.09 (n)
  • 97.99 (a)
Gtf2f2 16
Gtf2f2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF2F2 35
  • 99.46 (n)
  • 100 (a)
GTF2F2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2f2 35
  • 90.5 (n)
  • 97.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2F2 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2F2 35
  • 81.26 (n)
  • 89.56 (a)
GTF2F2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2F2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2f2 35
  • 75.81 (n)
  • 83.47 (a)
MGC75790 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398333 35
zebrafish
(Danio rerio)
Actinopterygii gtf2f2a 35
  • 73.23 (n)
  • 79.92 (a)
wufb39a05 35
gtf2f2a 36
  • 75 (a)
OneToMany
gtf2f2b 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6892 35
fruit fly
(Drosophila melanogaster)
Insecta TfIIFbgr 37
  • 46 (a)
TfIIFbeta 35
  • 55.32 (n)
  • 53.62 (a)
TfIIFbeta 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007002 35
  • 54.04 (n)
  • 54.04 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39B6A.36 37
  • 34 (a)
CELE_Y39B6A.36 35
  • 49.38 (n)
  • 37.34 (a)
Y39B6A.36 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFG2 36
  • 16 (a)
OneToOne
TFG2 38
Species with no ortholog for GTF2F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2F2 Gene

ENSEMBL:
Gene Tree for GTF2F2 (if available)
TreeFam:
Gene Tree for GTF2F2 (if available)

Paralogs for GTF2F2 Gene

Pseudogenes.org Pseudogenes for GTF2F2 Gene

genes like me logo Genes that share paralogs with GTF2F2: view

No data available for Paralogs for GTF2F2 Gene

Variants for GTF2F2 Gene

Sequence variations from dbSNP and Humsavar for GTF2F2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs912414 -- 45,125,278(+) AGAAA(A/T)TTTTT intron-variant
rs766530 -- 45,178,178(-) AACTG(C/T)TGGCC intron-variant
rs766531 -- 45,178,071(-) tgaag(C/G)aagac intron-variant
rs1610999 -- 45,178,340(-) AGAAG(-/AAG/AAGAAG/AAGCAG)CATAA intron-variant
rs1473741 -- 45,141,660(-) ACACA(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2F2 Gene

Variant ID Type Subtype PubMed ID
dgv1578n71 CNV Gain 21882294
nsv832596 CNV Loss 17160897
esv2656529 CNV Deletion 23128226
esv2660215 CNV Deletion 23128226
nsv518593 CNV Loss 19592680

Variation tolerance for GTF2F2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2F2 Gene

HapMap Linkage Disequilibrium report
GTF2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2F2 Gene

Disorders for GTF2F2 Gene

Relevant External Links for GTF2F2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2F2

No disorders were found for GTF2F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2F2 Gene

Publications for GTF2F2 Gene

  1. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W. … Murakami S. (Cell Res. 2003) 3 4 23 67
  2. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PMID: 16169872) Le T.T. … Murakami S. (J. Biochem. 2005) 3 23
  3. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. (PMID: 14612417) Hsu L.-C. … Yeung C.-Y. (Mol. Cell. Biol. 2003) 3 23
  4. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PMID: 10454543) Kim J.B. … Sharp P.A. (Mol. Cell. Biol. 1999) 3 23
  5. Transcriptional activation domain of human BTEB2, a GC box-binding factor. (PMID: 9089417) Kojima S. … Sogawa K. (J. Biochem. 1997) 3 23

Products for GTF2F2 Gene

Sources for GTF2F2 Gene

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