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GTF2F2 Gene

protein-coding   GIFtS: 62
GCID: GC13P045694

General Transcription Factor IIF, Polypeptide 2, 30kDa

(Previous names: general transcription factor IIF, polypeptide 1 (74kD subunit))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
General Transcription Factor IIF, Polypeptide 2, 30kDa1 2     TF2F22 5
RAP302 3 5     General Transcription Factor IIF, Polypeptide 1 (74kD Subunit)1
General Transcription Factor IIF 30 KDa Subunit2 3     BTF42
Transcription Initiation Factor IIF Subunit Beta2 3     TFIIF2
Transcription Initiation Factor RAP302 3     General Transcription Factor IIF Subunit 22
TFIIF-beta2 3     EC 3.6.4.123
ATP-Dependent Helicase GTF2F22 3     EC 3.6.18

External Ids:    HGNC: 46531   Entrez Gene: 29632   Ensembl: ENSG000001883427   OMIM: 1899695   UniProtKB: P139843   

Export aliases for GTF2F2 gene to outside databases

Previous GC identifers: GC13P043694 GC13P039681 GC13P044631 GC13P043492 GC13P044592 GC13P026496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GTF2F2 Gene:
GTF2F2 (general transcription factor IIF, polypeptide 2, 30kDa) is a protein-coding gene. Diseases associated with GTF2F2 include conjunctivitis, and colon adenocarcinoma. GO annotations related to this gene include ATP-dependent helicase activity.

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984
Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit
it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit
shows ATP-dependent DNA-helicase activity

Gene Wiki entry for GTF2F2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2F2 gene promoter:
         CHOP-10   Egr-2   POU2F1   POU2F1a   MyoD   POU6F1 (c2)   POU3F2   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2F2 promoter sequence
   Search Chromatin IP Primers for GTF2F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.12   HGNC cytogenetic band: 13q14

GTF2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2F2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P045694:  view genomic region     (about GC identifiers)

Start:
45,694,631 bp from pter      End:
45,858,240 bp from pter
Size:
163,610 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984 (See protein sequence)
Recommended Name: General transcription factor IIF subunit 2  
Size: 249 amino acids; 28380 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts
with URI1
3 PDB 3D structures from and Proteopedia for GTF2F2:
1BBY (3D)        1F3U (3D)        2BBY (3D)    
Secondary accessions: A6NNS5 Q5W0H3

Explore the universe of human proteins at neXtProt for GTF2F2: NX_P13984

Explore proteomics data for GTF2F2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys137, Lys147, Lys154, Lys200
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GTF2F2 (P13984) (see all 8)
     GAKQNTG  QIEESSKP  AFEKHQYYN  NHQYNIEYE 


    See GTF2F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004119.1  
    ENSEMBL proteins: 
     ENSP00000340823  
    Reactome Protein details: P13984

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors

    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003196 TFIIF_beta
     IPR016640 TFIIF-beta_subgr
     IPR011039 TFIIF_interaction

    Graphical View of Domain Structure for InterPro Entry P13984

    ProtoNet protein and cluster: P13984

    1 Blocks protein domain: IPB003196 Transcription initiation factor IIF

    UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984
    Similarity: Belongs to the TFIIF beta subunit family


    GTF2F2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2FB_HUMAN, P13984
    Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit
    it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit
    shows ATP-dependent DNA-helicase activity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for GTF2F2:
    general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across
    DNA templates

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI12737519
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    GTF2F2 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidGTF2F2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2FB_HUMAN, P13984: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005674transcription factor TFIIF complex IEA--
    GO:0015630microtubule cytoskeleton IDA--

    GTF2F2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF2F2 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    Formation of the Early Elongation Complex0.77
    Abortive elongation of HIV-1 transcript in the absence of Tat0.70
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Protein Acetylation and Deacetylation0.51
    Transcription of mRNA0.91
    Basal transcription factors0.50
    3mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    4HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    5Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2F2 (see all 6)
        Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Transcription of mRNA

    1 GeneGo (Thomson Reuters) Pathway for GTF2F2
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for GTF2F2
        Eukaryotic Transcription Initiation

    Selected Reactome Pathways for GTF2F2 (see all 27)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    1 Kegg Pathway  (Kegg details for GTF2F2):
        Basal transcription factors


    GTF2F2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF2F2
    Interactions:

        GeneGlobe Interaction Network for GTF2F2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2F2 (P139841, 2, 3 ENSP000003408234) via UniProtKB, MINT, STRING, and/or I2D (see all 221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    URI1O947631, 3, ENSP000003760974EBI-1030560,EBI-357067 I2D: score=3 STRING: ENSP00000376097
    RPL27AP467761, 3EBI-1030560,EBI-350581 I2D: score=1 
    TCTEX1D2Q8WW351, 3EBI-1030560,EBI-2692044 I2D: score=1 
    BAG6P463793, ENSP000003651314I2D: score=1 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    GTF2F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2F2 (T2FB)

    3 Novoseek inferred chemical compound relationships for GTF2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphodiester 53.5 2 10872452 (1), 8631733 (1)
    alanine 16.2 1 16169872 (1)
    atp 11.9 2 7982911 (1), 8631733 (1)



    GTF2F2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GTF2F2 gene: 
    NM_004128.2  

    Unigene Cluster for GTF2F2:

    General transcription factor IIF, polypeptide 2, 30kDa
    Hs.654582  [show with all ESTs]
    Unigene Representative Sequence: NM_004128
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340473(uc001uzw.3) ENST00000494087 ENST00000461904
    miRNA
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    Additional mRNA sequence: 

    AK291545.1 BC001771.1 BT019525.1 X16901.1 X59745.1 

    7 DOTS entries:

    DT.114042  DT.100796480  DT.100834650  DT.40130785  DT.99997299  DT.120789664  DT.120789671 

    Selected AceView cDNA sequences (see all 152):

    BE906625 CA429230 BM549442 CA443379 BF111786 BU632496 BU184889 CR609785 
    BG678009 BI755136 AI886116 CF272406 CA868274 CB126197 BQ422614 BP369463 
    CB126757 CR598374 AA831833 CA444768 BI755137 AI803556 BU619759 AA831445 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                    -     -           -     -                                 
    SP2:                    -     -           -     -                                 
    SP3:                          -           -     -                                 
    SP4:                                                                              
    SP5:                                      -     -                                 


    ECgene alternative splicing isoforms for GTF2F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGTGAAAC
    GTF2F2 Expression
    About this image

    GTF2F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2F2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654582
        Custom PCR Arrays for GTF2F2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GTF2F2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2f21 , 5 general transcription factor IIF, polypeptide 21, 5 90.09(n)1
    97.99(a)1
      14 (40.29 cM)5
    687051  NM_026816.31  NP_081092.11 
     758969375 
    chicken
    (Gallus gallus)
    Aves GTF2F21 general transcription factor IIF, polypeptide 2, 3 more 81.26(n)
    89.56(a)
      418843  XM_417039.4  XP_417039.3 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2F26
    general transcription factor IIF, polypeptide 2, 3...
    83(a)
    1 ↔ 1
    GL343395.1(657755-747269)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983332 transcription factor RAP30 75.73(n)    Z15132.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb39a052 Transcribed sequence with moderate similarity to protein more 74.9(n)    CF999714.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIF&bgr;3
    TfIIFbeta1
    transcription initiation from Pol II
    promoter more3
    Transcription factor TFIIFbeta1
    46(a)3
    55.32(n)1
    53.62(a)1
      3 86C63
    412901  NM_079581.41  NP_524305.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39B6A.363
    CELE_Y39B6A.361
    CELE_Y39B6A.361 34(a)3
    49.38(n)1
    37.34(a)1
      V(18990623-18994788)3
    1802431  NM_171571.41  NP_741661.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TFG2(YGR005C)4 TFIIF (Transcription Factor II) middle subunit; involved more   --   7(505859-504657) 852888  NP_011519.1 


    ENSEMBL Gene Tree for GTF2F2 (if available)
    TreeFam Gene Tree for GTF2F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GTF2F2 gene

    GTF2F2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GTF2F2
    PGOHUM00000243979 PGOHUM00000246098


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GTF2F2 (see all 2813)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852812241,2
    --45692673(+) TTTCCA/GTTCTT 1 -- us2k10--------
    rs1471426601,2
    C--45692688(+) AGCCCG/TTTCAT 1 -- us2k10--------
    rs1159113211,2
    C,F--45692754(+) CACCAC/TGTACA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs768606911,2
    C,F--45692871(+) TTTCAA/GTTTAT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1165148501,2
    F--45692983(+) TCATTT/ATCTGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1912215591,2
    --45692998(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs1403510111,2
    C--45693117(+) GATTAC/TAGGTG 1 -- us2k10--------
    rs1819343271,2
    --45693122(+) CAGGTA/GTGAGC 1 -- us2k10--------
    rs1443260741,2
    --45693166(+) TATTTA/GTTTTT 1 -- us2k10--------
    rs1874366811,2
    --45693221(+) ACGATC/TATGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GTF2F2 (45694631 - 45858240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GTF2F2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660215CNV Deletion23128226
    esv2656529CNV Deletion23128226
    nsv832596CNV Loss17160897
    nsv518593CNV Loss19592680
    dgv1578n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF2F2
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF2F2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189969    OMIM disorders: --

    14 diseases for GTF2F2:    
    About MalaCards
    conjunctivitis    colon adenocarcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    hiv-1    hepatitis    hepatitis c    hepatitis b
    tonsillitis    adenocarcinoma    thyroiditis    cerebritis
    malaria    endotheliitis


    GTF2F2 for disorders           About GeneDecksing


    Export disorders for GTF2F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF2F2 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with GTF2F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PubMed id 12737519)1, 2, 9 Wei W....Murakami S. (Cell Res. 2003)
    2. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PubMed id 10454543)1, 2, 9 Kim J.B.... Sharp P.A. (Mol. Cell. Biol. 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. (PubMed id 9689043)1, 2 Groft C.M.... Werner M.H. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    5. Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PubMed id 8162052)1, 3 Heng H.H....Tsui L.C. (Hum. Mol. Genet. 1994)
    6. Nucleotide and amino acid sequence of RAP30. (PubMed id 1840667)1, 2 Horikoshi M.... Roeder R.G. (Nucleic Acids Res. 1991)
    7. Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II. (PubMed id 2477704)1, 2 Sopta M.... Greenblatt J. (Nature 1989)
    8. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PubMed id 16169872)1, 9 Le T.T....Murakami S. (J. Biochem. 2005)
    9. Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. (PubMed id 8758937)1, 9 Dubrovskaya V....Tora L. (EMBO J. 1996)
    10. Structure-function analysis of Msx2-mediated transcriptional suppression. (PubMed id 9265625)1, 9 Newberry E.P....Towler D.A. (Biochemistry 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2963 HGNC: 4653 AceView: GTF2F2 Ensembl:ENSG00000188342 euGenes: HUgn2963
    ECgene: GTF2F2 Kegg: 2963 H-InvDB: GTF2F2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF2F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF2F2 gene:
    Search GeneIP for patents involving GTF2F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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