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Aliases for GTF2F2 Gene

Aliases for GTF2F2 Gene

  • General Transcription Factor IIF, Polypeptide 2, 30kDa 2 3
  • RAP30 3 4 6
  • Transcription Initiation Factor IIF Subunit Beta 3 4
  • General Transcription Factor IIF 30 KDa Subunit 3 4
  • Transcription Initiation Factor RAP30 3 4
  • ATP-Dependent Helicase GTF2F2 3 4
  • TFIIF-Beta 3 4
  • TF2F2 3 6
  • General Transcription Factor IIF, Polypeptide 1 (74kD Subunit) 2
  • General Transcription Factor IIF Subunit 2 3
  • EC 3.6.4.12 4
  • EC 3.6.1 63
  • TFIIF 3
  • BTF4 3

External Ids for GTF2F2 Gene

Summaries for GTF2F2 Gene

GeneCards Summary for GTF2F2 Gene

GTF2F2 (General Transcription Factor IIF, Polypeptide 2, 30kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for GTF2F2 Gene

  • TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Gene Wiki entry for GTF2F2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2F2 Gene

Genomics for GTF2F2 Gene

Genomic Location for GTF2F2 Gene

Start:
45,120,496 bp from pter
End:
45,284,909 bp from pter
Size:
164,414 bases
Orientation:
Plus strand

Genomic View for GTF2F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2F2 Gene

Regulatory Elements for GTF2F2 Gene

Proteins for GTF2F2 Gene

  • Protein details for GTF2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13984-T2FB_HUMAN
    Recommended name:
    General transcription factor IIF subunit 2
    Protein Accession:
    P13984
    Secondary Accessions:
    • A6NNS5
    • Q5W0H3

    Protein attributes for GTF2F2 Gene

    Size:
    249 amino acids
    Molecular mass:
    28380 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1.

    Three dimensional structures from OCA and Proteopedia for GTF2F2 Gene

neXtProt entry for GTF2F2 Gene

Proteomics data for GTF2F2 Gene at MOPED

Selected DME Specific Peptides for GTF2F2 Gene

Post-translational modifications for GTF2F2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys13, Lys137, Lys147, Lys154, and Lys200

Other Protein References for GTF2F2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GTF2F2 Gene

Gene Families for GTF2F2 Gene

HGNC:
  • GTF :General transcription factors

Protein Domains for GTF2F2 Gene

Suggested Antigen Peptide Sequences for GTF2F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13984

UniProtKB/Swiss-Prot:

T2FB_HUMAN
Family:
  • Belongs to the TFIIF beta subunit family.:
    • P13984
genes like me logo Genes that share domains with GTF2F2: view

Function for GTF2F2 Gene

Molecular function for GTF2F2 Gene

GENATLAS Biochemistry: general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across DNA templates
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Enzyme Numbers (IUBMB) for GTF2F2 Gene

Gene Ontology (GO) - Molecular Function for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003824 catalytic activity --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 12737519
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GTF2F2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GTF2F2 Gene

Localization for GTF2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2F2 Gene COMPARTMENTS Subcellular localization image for GTF2F2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005674 transcription factor TFIIF complex IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with GTF2F2: view

Pathways for GTF2F2 Gene

SuperPathways for GTF2F2 Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 mRNA Splicing - Major Pathway
3 Assembly of RNA Polymerase-II Initiation Complex
4 HIV Life Cycle
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with GTF2F2: view

Gene Ontology (GO) - Biological Process for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2F2: view

Compounds for GTF2F2 Gene

(3) Novoseek inferred chemical compound relationships for GTF2F2 Gene

Compound -log(P) Hits PubMed IDs
phosphodiester 53.5 2
alanine 16.2 1
atp 11.9 2
genes like me logo Genes that share compounds with GTF2F2: view

Transcripts for GTF2F2 Gene

mRNA/cDNA for GTF2F2 Gene

Unigene Clusters for GTF2F2 Gene

General transcription factor IIF, polypeptide 2, 30kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for GTF2F2 Gene

GeneLoc Exon Structure for
GTF2F2
ECgene alternative splicing isoforms for
GTF2F2

Expression for GTF2F2 Gene

mRNA expression in normal human tissues for GTF2F2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2F2 Gene

SOURCE GeneReport for Unigene cluster for GTF2F2 Gene Hs.654582

genes like me logo Genes that share expressions with GTF2F2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2F2 Gene

Orthologs for GTF2F2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2F2 35
  • 99.46 (n)
  • 100 (a)
GTF2F2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTF2F2 35
  • 92.1 (n)
  • 97.59 (a)
GTF2F2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
GTF2F2 35
  • 93.71 (n)
  • 97.99 (a)
mouse
(Mus musculus)
Mammalia Gtf2f2 35
  • 90.09 (n)
  • 97.99 (a)
Gtf2f2 16
Gtf2f2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2F2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2f2 35
  • 90.5 (n)
  • 97.59 (a)
chicken
(Gallus gallus)
Aves GTF2F2 35
  • 81.26 (n)
  • 89.56 (a)
GTF2F2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2F2 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398333 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2f2 35
  • 75.81 (n)
  • 83.47 (a)
MGC75790 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6892 35
zebrafish
(Danio rerio)
Actinopterygii gtf2f2a 35
  • 73.23 (n)
  • 79.92 (a)
gtf2f2a 36
  • 75 (a)
OneToMany
gtf2f2b 36
  • 71 (a)
OneToMany
wufb39a05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007002 35
  • 54.04 (n)
  • 54.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta TfIIFbeta 35
  • 55.32 (n)
  • 53.62 (a)
TfIIFbeta 36
  • 43 (a)
OneToOne
TfIIFbgr 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39B6A.36 35
  • 49.38 (n)
  • 37.34 (a)
Y39B6A.36 36
  • 33 (a)
OneToOne
Y39B6A.36 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFG2 36
  • 16 (a)
OneToOne
TFG2 38
Species with no ortholog for GTF2F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2F2 Gene

ENSEMBL:
Gene Tree for GTF2F2 (if available)
TreeFam:
Gene Tree for GTF2F2 (if available)

Paralogs for GTF2F2 Gene

Pseudogenes.org Pseudogenes for GTF2F2 Gene

genes like me logo Genes that share paralogs with GTF2F2: view

No data available for Paralogs for GTF2F2 Gene

Variants for GTF2F2 Gene

Sequence variations from dbSNP and Humsavar for GTF2F2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs766530 -- 45,178,178(-) AACTG(C/T)TGGCC intron-variant
rs766531 -- 45,178,071(-) tgaag(C/G)aagac intron-variant
rs912414 -- 45,125,278(+) AGAAA(A/T)TTTTT intron-variant
rs951853 -- 45,236,372(-) TATTT(C/G/T)CATAA intron-variant
rs957035 -- 45,226,512(-) AAATA(A/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2F2 Gene

Variant ID Type Subtype PubMed ID
dgv1578n71 CNV Gain 21882294
nsv832596 CNV Loss 17160897
esv2656529 CNV Deletion 23128226
esv2660215 CNV Deletion 23128226
nsv518593 CNV Loss 19592680

Relevant External Links for GTF2F2 Gene

HapMap Linkage Disequilibrium report
GTF2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2F2 Gene

Disorders for GTF2F2 Gene

No disorders were found for GTF2F2 Gene.

No data available for UniProtKB/Swiss-Prot for GTF2F2 Gene

Publications for GTF2F2 Gene

  1. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PMID: 10454543) Kim J.B. … Sharp P.A. (Mol. Cell. Biol. 1999) 3 4 23
  2. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W. … Murakami S. (Cell Res. 2003) 3 4 23
  3. Transcriptional activation domain of human BTEB2, a GC box-binding factor. (PMID: 9089417) Kojima S. … Sogawa K. (J. Biochem. 1997) 3 23
  4. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. (PMID: 14612417) Hsu L.-C. … Yeung C.-Y. (Mol. Cell. Biol. 2003) 3 23
  5. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PMID: 16169872) Le T.T. … Murakami S. (J. Biochem. 2005) 3 23

Products for GTF2F2 Gene

Sources for GTF2F2 Gene

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