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GTF2F1 Gene

protein-coding   GIFtS: 65
GCID: GC19M006381

General Transcription Factor IIF, Polypeptide 1, 74kDa

(Previous names: general transcription factor IIF, polypeptide 1 (74kD subunit))
  Search for GTF2F1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
General Transcription Factor IIF, Polypeptide 1, 74kDa1 2     General Transcription Factor IIF, Polypeptide 1 (74kD Subunit)1
RAP742 3 5     BTF42
General Transcription Factor IIF 74 KDa Subunit2 3     TF2F12
Transcription Initiation Factor IIF Subunit Alpha2 3     TFIIF2
Transcription Initiation Factor RAP742 3     General Transcription Factor IIF Subunit 12
TFIIF-alpha2 3     

External Ids:    HGNC: 46521   Entrez Gene: 29622   Ensembl: ENSG000001256517   OMIM: 1899685   UniProtKB: P352693   

Export aliases for GTF2F1 gene to outside databases

Previous GC identifers: GC19M006474 GC19M006319 GC19M006330 GC19M006235 GC19M006139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GTF2F1 Gene:
GTF2F1 (general transcription factor IIF, polypeptide 1, 74kDa) is a protein-coding gene. GO annotations related to this gene include transcription factor binding and phosphatase activator activity.

UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269
Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit
it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation

Gene Wiki entry for GTF2F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2F1 gene promoter:
         Max1   HEN1   AhR   AREB6   Olf-1   XBP-1   Zic3   c-Myc   Ik-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2F1 promoter sequence
   Search Chromatin IP Primers for GTF2F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GTF2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2F1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006381:  view genomic region     (about GC identifiers)

Start:
6,379,580 bp from pter      End:
6,393,992 bp from pter
Size:
14,413 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269 (See protein sequence)
Recommended Name: General transcription factor IIF subunit 1  
Size: 517 amino acids; 58240 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1
Caution: Was reported (PubMed:10428810) to have a protein kinase activity and to autophosphorylates on Ser-385 and
Thr-389
6 PDB 3D structures from and Proteopedia for GTF2F1:
1F3U (3D)        1I27 (3D)        1J2X (3D)        1NHA (3D)        1ONV (3D)        2K7L (3D)    
Secondary accessions: B2RCS0 Q9BWN0

Explore the universe of human proteins at neXtProt for GTF2F1: NX_P35269

Explore proteomics data for GTF2F1 at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases1
  • Ubiquitination2 at Lys169
  • Modification sites at PhosphoSitePlus

  • See GTF2F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002087.2  
    ENSEMBL proteins: 
     ENSP00000377969   ENSP00000469091   ENSP00000471403   ENSP00000471542   ENSP00000392107  
    Reactome Protein details: P35269

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors

    3 InterPro protein domains:
     IPR008851 TFIIF-alpha
     IPR011991 WHTH_DNA-bd_dom
     IPR011039 TFIIF_interaction

    Graphical View of Domain Structure for InterPro Entry P35269

    ProtoNet protein and cluster: P35269

    1 Blocks protein domain: IPB008851 Transcription initiation factor IIF

    UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269
    Similarity: Belongs to the TFIIF alpha subunit family


    Find genes that share domains with GTF2F1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2FA_HUMAN, P35269
    Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit
    it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for GTF2F1:
    general transcription factor IIF,polypeptide 1 (74kDa),increasing the average rate of RNA chain elongation across
    DNA templates

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity TAS7854423
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding IPI12721286
    GO:0008134transcription factor binding IPI8625415
         
    Find genes that share ontologies with GTF2F1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2F1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2FA_HUMAN, P35269: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005674transcription factor TFIIF complex TAS1734283
    GO:0030054cell junction IDA--

    Find genes that share ontologies with GTF2F1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF2F1 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Protein Acetylation and Deacetylation0.51
    Transcription of mRNA0.91
    Basal transcription factors0.50
    2Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    HIV elongation arrest and recovery0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.72
    Formation of the Early Elongation Complex0.77
    Transcription of the HIV genome0.71
    3mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    4HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    5Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82


    Find genes that share SuperPaths with GTF2F1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2F1 (see all 6)
        Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Transcription of mRNA

    1 Cell Signaling Technology (CST) Pathway for GTF2F1
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for GTF2F1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    Selected Reactome Pathways for GTF2F1 (see all 27)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    1 Kegg Pathway  (Kegg details for GTF2F1):
        Basal transcription factors

        Pathway & Disease-focused RT2 Profiler PCR Array including GTF2F1: 
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GTF2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2F1 (P352691, 2, 3 ENSP000003779694) via UniProtKB, MINT, STRING, and/or I2D (see all 210)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996892, 3, ENSP000002789194MINT-63690 I2D: score=5 STRING: ENSP00000278919
    PTNP212462, 3MINT-63689 I2D: score=5 
    GTF2H4Q927593, ENSP000002598954I2D: score=1 STRING: ENSP00000259895
    ENSG00000221974Q927593I2D: score=1 
    ENSG00000226384Q927593I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:00063707-methylguanosine mRNA capping TAS--

    Find genes that share ontologies with GTF2F1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2F1 (T2FA)

    2 Novoseek inferred chemical compound relationships for GTF2F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 16.3 1 18284209 (1)
    zinc 0 2 15385556 (1), 8504927 (1)



    Find genes that share compounds with GTF2F1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GTF2F1 gene: 
    NM_002096.2  

    Unigene Cluster for GTF2F1:

    General transcription factor IIF, polypeptide 1, 74kDa
    Hs.68257  [show with all ESTs]
    Unigene Representative Sequence: NM_002096
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394456(uc010xjb.1 uc010xjc.1 uc002meq.2) ENST00000593678
    ENST00000594213 ENST00000594965 ENST00000595047 ENST00000598607 ENST00000429701

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    Additional mRNA sequence: 

    AK293124.1 AK302178.1 AK315240.1 BC000120.1 BC013007.2 BT007097.1 CR456798.1 X64002.1 
    X64037.1 

    10 DOTS entries:

    DT.315980  DT.92445174  DT.121499285  DT.100001515  DT.100819253  DT.92445167  DT.97847120  DT.40114942 
    DT.91654735  DT.91968175 

    Selected AceView cDNA sequences (see all 302):

    AK055490 BM818653 BI822877 CD367758 CK903018 AW404784 BU849836 BM709285 
    BM723723 BQ893163 BU609071 H41752 BQ070397 BU175972 BM975394 BM722851 
    BQ004602 BE349278 BX488964 BQ955277 BF081906 BQ894306 NM_004158 AA326407 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                          -           -                                   -     -                                                                           
    SP2:                                                                                                                                                        -   
    SP3:        -                 -           -                                                                                                                     
    SP4:                          -           -                 -                 -     -                                                                           
    SP5:                                      -                                   -     -                                                                           

    ExUns: 18b · 18c · 18d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for GTF2F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGGGAG
    GTF2F1 Expression
    About this image


    GTF2F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GTF2F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.68257
        Pathway & Disease-focused RT2 Profiler PCR Array including GTF2F1: 
              Transcription Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GTF2F1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2f11 , 5 general transcription factor IIF, polypeptide 11, 5 86.02(n)1
    93.11(a)1
      17 (29.62 cM)5
    980531  NM_133801.21  NP_598562.11 
     570034055 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2F16
    general transcription factor IIF, polypeptide 1, 7...
    81(a)
    1 ↔ 1
    2(76427735-76444354)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983252 RAP74 subunit of transcription factor IIF 75.2(n)    AY114105.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd13c082 wufd13c08 77.46(n)   325832  BC045951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIFalpha3 transcription initiation from Pol II
    promoter more
    49(a)   83E5   --
    worm
    (Caenorhabditis elegans)
    Secernentea C01F1.16
    Protein C01F1.1 (C01F1.1) mRNA, complete cds
    31(a)
    1 ↔ 1
    II(4301607-4305287) WBGene00015296


    ENSEMBL Gene Tree for GTF2F1 (if available)
    TreeFam Gene Tree for GTF2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GTF2F1 (see all 537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880446111,2
    --6379247(+) GCTGAC/GGTGGG 1 -- ds50010--------
    rs801136881,2
    F--6379350(+) GGTGTG/ACACTA 1 -- ds50011Minor allele frequency- A:0.12NA 120
    rs1467755151,2
    --6379544(+) AACAGA/CGTAGC 1 -- ds50010--------
    rs11301941,2
    F--6379647(-) CACCAC/TGCCAC 1 -- ut313Minor allele frequency- T:0.12NA 124
    rs72577941,2
    C,F,A,H--6379709(+) gcctaC/Tggaac 1 -- ut315Minor allele frequency- T:0.01NS EA WA 536
    rs3759765821,2
    C--6379753(+) GGCTA-/TTTTTT 1 -- ut310--------
    rs113596971,2
    F--6379767(+) TTTTTT/-GTGCC 1 -- ut31 trp32Minor allele frequency- -:0.50NA CSA 4
    rs792540901,2
    C,F--6379964(+) GAAGGG/CAGAAC 1 -- ut311Minor allele frequency- C:0.01EA 120
    rs1181744751,2
    --6380022(+) GAGGCC/TGAGCC 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs126093231,2
    C,F,A,H--6380023(+) AGGCCG/AAGCCA 1 -- ut3121Minor allele frequency- A:0.23NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for GTF2F1 (6379580 - 6393992 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GTF2F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667354CNV Deletion23128226
    nsv513757CNV Insertion21212237
    nsv910916CNV Loss21882294
    dgv3700n71CNV Loss21882294
    nsv910911CNV Loss21882294
    dgv3698n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF2F1
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF2F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189968    OMIM disorders: --


    Find genes that share disorders with GTF2F1           About GenesLikeMe

    Genetic Association Database (GAD): GTF2F1
    Human Genome Epidemiology (HuGE) Navigator: GTF2F1 (1 document)

    Export disorders for GTF2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF2F1 gene, integrated from 10 sources (see all 192):
    (articles sorted by number of sources associating them with GTF2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. (PubMed id 1734284)1, 2, 3, 9 Finkelstein A.... Burton Z.F. (Nature 1992)
    2. Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. (PubMed id 12578358)1, 2, 9 Nguyen B.D....Omichinski J.G. (Biochemistry 2003)
    3. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. (PubMed id 12732728)1, 2, 9 Nguyen B.D.... Omichinski J.G. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    4. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)1, 2, 9 Hisatake K.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    5. Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution. (PubMed id 11183778)1, 2, 9 Gaiser F.... Richmond T.J. (J. Mol. Biol. 2000)
    6. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PubMed id 12737519)1, 2, 9 Wei W....Murakami S. (Cell Res. 2003)
    7. Molecular mechanism of recruitment of TFIIF-associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF. (PubMed id 12591941)1, 2, 9 Kamada K.... Burley S.K. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF. (PubMed id 1734283)1, 2, 9 Aso T.... Yasukochi Y. (Nature 1992)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2962 HGNC: 4652 AceView: GTF2F1andPSPN Ensembl:ENSG00000125651 euGenes: HUgn2962
    ECgene: GTF2F1 Kegg: 2962 H-InvDB: GTF2F1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF2F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GTF2F1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF2F1 gene:
    Search GeneIP for patents involving GTF2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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