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Aliases for GTF2E2 Gene

Aliases for GTF2E2 Gene

  • General Transcription Factor IIE Subunit 2 2 3 4 5
  • General Transcription Factor IIE, Polypeptide 2, Beta 34kDa 2 3
  • TFIIE Beta Subunit 2 3
  • TFIIE-Beta 3 4
  • TF2E2 3 4
  • General Transcription Factor IIE, Polypeptide 2 (Beta Subunit, 34kD) 2
  • Transcription Initiation Factor IIE Subunit Beta 3
  • TFIIE-B 3
  • TTD6 3
  • FE 3

External Ids for GTF2E2 Gene

Previous GeneCards Identifiers for GTF2E2 Gene

  • GC08M030291
  • GC08M030887
  • GC08M030493
  • GC08M030429
  • GC08M030555
  • GC08M028981

Summaries for GTF2E2 Gene

GeneCards Summary for GTF2E2 Gene

GTF2E2 (General Transcription Factor IIE Subunit 2) is a Protein Coding gene. Diseases associated with GTF2E2 include Trichothiodystrophy 1, Photosensitive. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for GTF2E2 Gene

  • Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Gene Wiki entry for GTF2E2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2E2 Gene

Genomics for GTF2E2 Gene

Regulatory Elements for GTF2E2 Gene

Enhancers for GTF2E2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GTF2E2 on UCSC Golden Path with GeneCards custom track

Promoters for GTF2E2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GTF2E2 Gene

Chromosome:
8
Start:
30,578,318 bp from pter
End:
30,658,251 bp from pter
Size:
79,934 bases
Orientation:
Minus strand

Genomic View for GTF2E2 Gene

Genes around GTF2E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2E2 Gene

Proteins for GTF2E2 Gene

  • Protein details for GTF2E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29084-T2EB_HUMAN
    Recommended name:
    Transcription initiation factor IIE subunit beta
    Protein Accession:
    P29084
    Secondary Accessions:
    • D3DSV2
    • Q9H2B9

    Protein attributes for GTF2E2 Gene

    Size:
    291 amino acids
    Molecular mass:
    33044 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H. Interacts with ATF7IP.

    Three dimensional structures from OCA and Proteopedia for GTF2E2 Gene

neXtProt entry for GTF2E2 Gene

Post-translational modifications for GTF2E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2E2 Gene

No data available for DME Specific Peptides for GTF2E2 Gene

Domains & Families for GTF2E2 Gene

Gene Families for GTF2E2 Gene

Protein Domains for GTF2E2 Gene

Suggested Antigen Peptide Sequences for GTF2E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29084

UniProtKB/Swiss-Prot:

T2EB_HUMAN :
  • Contains 1 TFIIE beta DNA-binding domain.
  • Belongs to the TFIIE beta subunit family.
Domain:
  • Contains 1 TFIIE beta DNA-binding domain.
Family:
  • Belongs to the TFIIE beta subunit family.
genes like me logo Genes that share domains with GTF2E2: view

Function for GTF2E2 Gene

Molecular function for GTF2E2 Gene

GENATLAS Biochemistry:
general transcription factor IIE,beta polypeptide (34kDa)
UniProtKB/Swiss-Prot Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Gene Ontology (GO) - Molecular Function for GTF2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 7926747
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GTF2E2: view
genes like me logo Genes that share phenotypes with GTF2E2: view

Animal Models for GTF2E2 Gene

MGI Knock Outs for GTF2E2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2E2 Gene

Localization for GTF2E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2E2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2E2 Gene COMPARTMENTS Subcellular localization image for GTF2E2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GTF2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005673 transcription factor TFIIE complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GTF2E2: view

Pathways & Interactions for GTF2E2 Gene

genes like me logo Genes that share pathways with GTF2E2: view

Gene Ontology (GO) - Biological Process for GTF2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2E2: view

No data available for SIGNOR curated interactions for GTF2E2 Gene

Drugs & Compounds for GTF2E2 Gene

No Compound Related Data Available

Transcripts for GTF2E2 Gene

Unigene Clusters for GTF2E2 Gene

General transcription factor IIE, polypeptide 2, beta 34kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2E2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - -
SP2:
SP3:

Relevant External Links for GTF2E2 Gene

GeneLoc Exon Structure for
GTF2E2
ECgene alternative splicing isoforms for
GTF2E2

Expression for GTF2E2 Gene

mRNA expression in normal human tissues for GTF2E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF2E2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF2E2 Gene



Protein tissue co-expression partners for GTF2E2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF2E2 Gene:

GTF2E2

SOURCE GeneReport for Unigene cluster for GTF2E2 Gene:

Hs.77100
genes like me logo Genes that share expression patterns with GTF2E2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2E2 Gene

Orthologs for GTF2E2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2E2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2E2 34
  • 91.46 (n)
  • 94.12 (a)
GTF2E2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2E2 34
  • 93.7 (n)
  • 95.53 (a)
GTF2E2 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF2E2 34
  • 99.77 (n)
  • 100 (a)
GTF2E2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2e2 34
  • 89.69 (n)
  • 94.16 (a)
mouse
(Mus musculus)
Mammalia Gtf2e2 16
Gtf2e2 35
  • 94 (a)
OneToOne
Gtf2e2 34
  • 90.49 (n)
  • 94.5 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF2E2 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2E2 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2E2 34
  • 78.21 (n)
  • 82.17 (a)
GTF2E2 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2E2 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2e2 34
  • 75.77 (n)
  • 83.33 (a)
Str.6435 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8438 34
zebrafish
(Danio rerio)
Actinopterygii gtf2e2 34
  • 72.18 (n)
  • 78.28 (a)
gtf2e2 35
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14079 34
fruit fly
(Drosophila melanogaster)
Insecta TfIIEbgr 36
  • 52 (a)
TfIIEbeta 34
  • 56.93 (n)
  • 58.76 (a)
TfIIEbeta 35
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005382 34
  • 56.92 (n)
  • 57.04 (a)
worm
(Caenorhabditis elegans)
Secernentea F54D5.11 36
  • 36 (a)
CELE_F54D5.11 34
  • 49.52 (n)
  • 41.3 (a)
F54D5.11 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8548 34
Species where no ortholog for GTF2E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2E2 Gene

ENSEMBL:
Gene Tree for GTF2E2 (if available)
TreeFam:
Gene Tree for GTF2E2 (if available)

Paralogs for GTF2E2 Gene

Pseudogenes.org Pseudogenes for GTF2E2 Gene

genes like me logo Genes that share paralogs with GTF2E2: view

No data available for Paralogs for GTF2E2 Gene

Variants for GTF2E2 Gene

Sequence variations from dbSNP and Humsavar for GTF2E2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2978277 - 30,612,300(-) TGTCA(A/G)GGTAA reference, missense
rs2229299 - 30,612,450(-) AGTAA(C/T)AGATG reference, missense
rs1114279 -- 30,595,551(+) TTTGC(C/T)GGATG intron-variant
rs2978267 -- 30,635,693(-) AGATA(A/G)AGGAG intron-variant
rs2978268 -- 30,631,171(-) TGTTG(G/T)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2E2 Gene

Variant ID Type Subtype PubMed ID
esv2661538 CNV deletion 23128226
esv2668521 CNV deletion 23128226
esv2678843 CNV deletion 23128226
esv3616789 CNV loss 21293372
esv3616790 CNV loss 21293372
esv3616791 CNV loss 21293372
nsv526509 CNV gain 19592680

Variation tolerance for GTF2E2 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2E2 Gene

Human Gene Mutation Database (HGMD)
GTF2E2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2E2 Gene

Disorders for GTF2E2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF2E2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trichothiodystrophy 1, photosensitive
  • amish brittle hair brain syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GTF2E2

Genetic Association Database (GAD)
GTF2E2
Human Genome Epidemiology (HuGE) Navigator
GTF2E2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2E2
genes like me logo Genes that share disorders with GTF2E2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF2E2 Gene

Publications for GTF2E2 Gene

  1. Conserved sequence motifs in the small subunit of human general transcription factor TFIIE. (PMID: 1956404) Sumimoto H. … Roeder R.G. (Nature 1991) 2 3 4 65
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3 46 65
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 46 65
  4. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PMID: 19106100) Liu L. … Nakao M. (J. Biol. Chem. 2009) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for GTF2E2 Gene

Sources for GTF2E2 Gene

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