Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GTF2E2 Gene

protein-coding   GIFtS: 64
GCID: GC08M030429

General Transcription Factor IIE, Polypeptide 2, Beta 34kDa

(Previous names: general transcription factor IIE, polypeptide 2 (beta subunit,...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
General Transcription Factor IIE, Polypeptide 2, Beta 34kDa1 2     General Transcription Factor IIE, Polypeptide 2 (Beta Subunit, 34kD)1
General Transcription Factor IIE Subunit 22 3     FE2
TF2E22 3     TFIIE-B2
TFIIE-beta2 3     Transcription Initiation Factor IIE Subunit Beta2

External Ids:    HGNC: 46511   Entrez Gene: 29612   Ensembl: ENSG000001972657   OMIM: 1899645   UniProtKB: P290843   

Export aliases for GTF2E2 gene to outside databases

Previous GC identifers: GC08M030291 GC08M030887 GC08M030493 GC08M030555 GC08M028981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for GTF2E2 Gene:
GTF2E2 (general transcription factor IIE, polypeptide 2, beta 34kDa) is a protein-coding gene. Diseases associated with GTF2E2 include werner syndrome, and ulcerative colitis.

UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084
Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase
and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA
polymerase

Gene Wiki entry for GTF2E2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2E2 gene promoter:
         SRF   SRF (504 AA)   Bach2   NCX/Ncx   MEF-2   POU3F2   MEF-2A   Pax-3   IRF-2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2E2 promoter sequence
   Search Chromatin IP Primers for GTF2E2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2E2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

GTF2E2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2E2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M030429:  view genomic region     (about GC identifiers)

Start:
30,435,835 bp from pter      End:
30,515,768 bp from pter
Size:
79,934 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084 (See protein sequence)
Recommended Name: Transcription initiation factor IIE subunit beta  
Size: 291 amino acids; 33044 Da
Subunit: Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H. Interacts with ATF7IP
2 PDB 3D structures from and Proteopedia for GTF2E2:
1D8J (3D)        1D8K (3D)    
Secondary accessions: D3DSV2 Q9H2B9

Explore the universe of human proteins at neXtProt for GTF2E2: NX_P29084

Explore proteomics data for GTF2E2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GTF2E2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002086.1  
    ENSEMBL proteins: 
     ENSP00000348168   ENSP00000428981   ENSP00000429921   ENSP00000429312  
    Reactome Protein details: P29084

    GTF2E2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GTF2E2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GTF2E2
    GenScript Custom Purified and Recombinant Proteins Services for GTF2E2
    Novus Biologicals GTF2E2 Proteins
    Novus Biologicals GTF2E2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GTF2E2
    Cloud-Clone Corp. Proteins for GTF2E2

    GTF2E2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GTF2E2
    OriGene Custom Antibody Services for GTF2E2
    Novus Biologicals GTF2E2 Antibodies
    Abcam antibodies for GTF2E2
    Cloud-Clone Corp. Antibodies for GTF2E2
    ThermoFisher Antibodies for GTF2E2
    LSBio Antibodies in human, mouse, rat for GTF2E2

    GTF2E2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GTF2E2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTF2E2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GTF2E2
    Cloud-Clone Corp. CLIAs for GTF2E2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GTF: General transcription factors

    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR016656 TFIIE-bsu
     IPR003166 TFIIE_bsu_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P29084

    ProtoNet protein and cluster: P29084

    1 Blocks protein domain: IPB003166 Transcription factor TFIIE beta subunit

    UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084
    Similarity: Belongs to the TFIIE beta subunit family
    Similarity: Contains 1 TFIIE beta DNA-binding domain


    GTF2E2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2EB_HUMAN, P29084
    Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase
    and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA
    polymerase

         Genatlas biochemistry entry for GTF2E2:
    general transcription factor IIE,beta polypeptide (34kDa)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16547462
    GO:0044822poly(A) RNA binding IDA--
         
    GTF2E2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for GTF2E2:
     Decreased viability  Increased G1 DNA content  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2E2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTF2E2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GTF2E2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GTF2E2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GTF2E2:
    hsa-mir-766-3p (MIRT039017)

    Block miRNA regulation of human, mouse, rat GTF2E2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GTF2E2 (see all 12):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4268 hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidGTF2E2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GTF2E2
    Predesigned siRNA for gene silencing in human, mouse, rat GTF2E2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GTF2E2

    Clone
    Products:
         
    OriGene clones in human, mouse for GTF2E2 (see all 8)
    OriGene ORF clones in mouse, rat for GTF2E2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GTF2E2 (NM_002095)
    Sino Biological Human cDNA Clone for GTF2E2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF2E2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF2E2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GTF2E2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GTF2E2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    T2EB_HUMAN, P29084: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005673transcription factor TFIIE complex IEA--
    GO:0005737cytoplasm IDA--

    GTF2E2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GTF2E2 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    Glucocorticoid Receptor Signaling0.43
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2E2 (see all 9)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 BioSystems Pathway for GTF2E2
        Eukaryotic Transcription Initiation


    Selected Reactome Pathways for GTF2E2 (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    3 Kegg Pathways  (Kegg details for GTF2E2):
        Basal transcription factors
    Epstein-Barr virus infection
    Viral carcinogenesis


    GTF2E2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF2E2
    Interactions:

        Search GeneGlobe Interaction Network for GTF2E2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2E2 (P290841, 2, 3 ENSP000003481684) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2E1P290831, 2, 3, ENSP000002838754EBI-2853321,EBI-5462215 MINT-1894096 MINT-1894113 I2D: score=10 STRING: ENSP00000283875
    GTF2F2P139843, ENSP000003408234I2D: score=3 STRING: ENSP00000340823
    ATF7IPQ6VMQ63, ENSP000002611684I2D: score=2 STRING: ENSP00000261168
    ERCC3P194473, ENSP000002853984I2D: score=2 STRING: ENSP00000285398
    GTF2A1P526553, ENSP000002981734I2D: score=2 STRING: ENSP00000298173
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    GTF2E2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2E2 (T2EB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GTF2E2 gene: 
    NM_002095.4  

    Unigene Cluster for GTF2E2:

    General transcription factor IIE, polypeptide 2, beta 34kDa
    Hs.77100  [show with all ESTs]
    Unigene Representative Sequence: BC030572
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355904(uc003xig.3) ENST00000522833 ENST00000523499 ENST00000518599
    ENST00000518445
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GTF2E2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GTF2E2 (see all 12):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4268 hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidGTF2E2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GTF2E2
    Predesigned siRNA for gene silencing in human, mouse, rat GTF2E2
    Clone
    Products:
         
    OriGene clones in human, mouse for GTF2E2 (see all 8)
    OriGene ORF clones in mouse, rat for GTF2E2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GTF2E2 (NM_002095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF2E2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF2E2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GTF2E2
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF2E2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF2E2
      QuantiTect SYBR Green Assays in human, mouse, rat GTF2E2
      QuantiFast Probe-based Assays in human, mouse, rat GTF2E2

    Additional mRNA sequence: 

    BC001775.1 BC030572.2 S67861.1 X63469.1 

    6 DOTS entries:

    DT.87017043  DT.439726  DT.92431229  DT.100820125  DT.92431223  DT.92431228 

    Selected AceView cDNA sequences (see all 242):

    BQ049799 CD369738 BU838437 BM454383 BU193111 AA489374 BM726717 BC030572 
    CK819595 CB134119 BM974223 F10557 W94196 BE513765 BC001775 BG024662 
    BM717184 CR594329 NM_002095 AW051533 BM727310 BU630090 BF439978 CR611388 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2E2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                                                  -     -     -               
    SP2:                                                                              
    SP3:                                                                              


    ECgene alternative splicing isoforms for GTF2E2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GTF2E2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTGTCTT
    GTF2E2 Expression
    About this image


    GTF2E2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Liver Lobule
    GTF2E2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2E2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77100
        Custom PCR Arrays for GTF2E2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GTF2E2
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF2E2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF2E2
    QuantiTect SYBR Green Assays in human, mouse, rat GTF2E2
    QuantiFast Probe-based Assays in human, mouse, rat GTF2E2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GTF2E2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2e21 , 5 general transcription factor II E, polypeptide 2 (beta more1, 5 90.49(n)1
    94.5(a)1
      8 (20.79 cM)5
    681531  NM_001167921.11  NP_001161393.11 
     337319145 
    chicken
    (Gallus gallus)
    Aves GTF2E21 general transcription factor IIE, polypeptide 2, beta more 78.21(n)
    82.17(a)
      771227  XM_001233399.3  XP_001233400.1 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2E26
    general transcription factor IIE, polypeptide 2, b...
    88(a)
    1 ↔ 1
    GL343257.1(531356-572640)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84382 Xenopus laevis transcribed sequence with moderate similarity more 76.72(n)    CA981148.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gtf2e22 general transcription factor IIE, polypeptide 2, beta 74.28(n)   334854  CD760310.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIE&bgr;3
    TfIIEbeta1
    transcription initiation from Pol II
    promoter more3
    Transcription factor IIEbeta1
    52(a)3
    56.93(n)1
    58.76(a)1
      64B13
    385271  NM_079199.31  NP_523923.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F54D5.113
    CELE_F54D5.111
    transcription intiation factor
    TFIIE-BETA3
    CELE_F54D5.111
    36(a)3
    49.52(n)1
    41.3(a)1
      II(11540627-11542229)3
    1747651  NM_064065.61  NP_496466.11 


    ENSEMBL Gene Tree for GTF2E2 (if available)
    TreeFam Gene Tree for GTF2E2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GTF2E2 gene

    GTF2E2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GTF2E2
    PGOHUM00000242863 PGOHUM00000241427


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GTF2E2 (see all 1361)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853929131,2
    --30435724(+) CGATCC/TTTTAA 1 -- int10--------
    rs1479078211,2
    --30435734(+) ACCTCA/GTGATC 1 -- int10--------
    rs1470305671,2
    --30435806(+) ACTGAC/TGCTTC 1 -- int10--------
    rs1903186241,2
    --30435807(+) CTGACA/GCTTCT 1 -- int10--------
    rs286879831,2
    C,F--30435841(+) GACATC/TCAGCA 1 -- int12Minor allele frequency- T:0.15CSA WA 120
    rs1825610811,2
    --30436099(+) CATTCA/GAGACT 1 -- ut310--------
    rs749487721,2
    C,F--30436265(+) TGAGCC/TCATTC 1 -- ut311Minor allele frequency- T:0.05WA 118
    rs1381790461,2
    --30436307(+) CACTTA/GTTTTG 1 -- ut310--------
    rs1492156421,2
    --30436629(+) AGCATA/GCCCAG 1 -- int10--------
    rs1433979201,2
    --30436646(+) GTGGCC/TGAGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for GTF2E2 (30435835 - 30515768 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GTF2E2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678843CNV Deletion23128226
    esv2668521CNV Deletion23128226
    esv2661538CNV Deletion23128226
    nsv890703CNV Loss21882294
    nsv526509CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF2E2
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF2E2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 189964    OMIM disorders: --

    4 diseases for GTF2E2:    
    About MalaCards
    werner syndrome    ulcerative colitis    hiv-1    malaria

    1 disease from the University of Copenhagen DISEASES database for GTF2E2:
    Werner syndrome

    GTF2E2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GTF2E2
    Human Genome Epidemiology (HuGE) Navigator: GTF2E2 (1 document)

    Export disorders for GTF2E2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GTF2E2 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with GTF2E2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved sequence motifs in the small subunit of human general transcription factor TFIIE. (PubMed id 1956404)1, 2, 3 Sumimoto H....Roeder R.G. (Nature 1991)
    2. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    3. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)
    4. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)1, 2 Liu L.... Nakao M. (J. Biol. Chem. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68. (PubMed id 10792464)1, 2 Kang S.-W.... Horikoshi M. (Genes Cells 2000)
    7. Structure and functional properties of human general transcription factor IIE. (PubMed id 1956398)1, 2 Peterson M.G.... Tjian R. (Nature 1991)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 23934736)1 Yu B....Boerwinkle E. (Genet. Epidemiol. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2961 HGNC: 4651 AceView: GTF2E2 Ensembl:ENSG00000197265 euGenes: HUgn2961
    ECgene: GTF2E2 Kegg: 2961 H-InvDB: GTF2E2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GTF2E2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GTF2E2 gene:
    Search GeneIP for patents involving GTF2E2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GTF2E2   OriGene RNAi products in human, mouse, rat for GTF2E2  
     OriGene qPCR primer pairs and template standards for GTF2E2   OriGene Protein Over-expression Lysate for GTF2E2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GTF2E2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GTF2E2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GTF2E2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GTF2E2   OriGene Custom Protein Services for GTF2E2  

     
     
     Block miRNA regulation of human, mouse, rat GTF2E2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GTF2E2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2E2 Predesigned siRNA for gene silencing in human, mouse, rat GTF2E2
     QuantiFast Probe-based Assays in human, mouse, rat GTF2E2 QuantiTect SYBR Green Assays in human, mouse, rat GTF2E2
     Custom PCR Arrays for GTF2E2 Search Chromatin IP Primers for GTF2E2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF2E2  Search GeneGlobe Interaction Network for GTF2E2
     Regulatory tfbs in GTF2E2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GTF2E2 GenScript cDNA clones with any tag delivered in your preferred vector for GTF2E2
     GenScript Custom Assay Services for GTF2E2 GenScript Custom overexpressing Cell Line Services for GTF2E2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GTF2E2 (T2EB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GTF2E2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GTF2E2 antibodies
     GTF2E2 proteins
     GTF2E2 lysates
     Antibodies for GTF2E2
     See all of Abcam's Antibodies, Kits and Proteins for GTF2E2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GTF2E2
     Proteins for GTF2E2
     Antibodies for GTF2E2
     ELISAs for GTF2E2
     CLIAs for GTF2E2



     Browse ESI BIO Cell Lines and PureStem Progenitors for GTF2E2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E2
     SwitchGear 3'UTR luciferase reporter plasmids for GTF2E2
     SwitchGear Promoter luciferase reporter plasmids for GTF2E2
     ThermoFisher Antibodies for GTF2E2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF2E2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2E2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTF2E2
     LSBio Antibodies in human, mouse, rat for GTF2E2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GTF2E2 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4