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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GTF2E2 Gene

protein-coding GIFtS: 62
GCID: GC08M030429

general transcription factor IIE, polypeptide 2, beta 34kDa

(Previous names: general transcription factor IIE, polypeptide 2 (beta subunit,...)

Explore 3 diseases affiliated with
GTF2E2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
General Transcription Factor IIE, Polypeptide 2, Beta 34kDa¹ ²		General Transcription Factor IIE Subunit 2² ³
TF2E2¹ ² ³		TFIIE-Beta¹
FE¹ ²		General Transcription Factor IIE, Polypeptide 2 (Beta Subunit, 34kD)¹
TFIIE-B¹ ²		Transcription Initiation Factor IIE Subunit Beta²

External Ids:	HGNC: 4651¹	Entrez Gene: 2961²	Ensembl: ENSG00000197265⁷	OMIM: 189964⁵	UniProtKB: P29084³

Export aliases for GTF2E2 gene to outside databases

Previous GC identifers: GC08M030291 GC08M030887 GC08M030493 GC08M030555 GC08M028981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084

Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and

DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Gene Wiki entry for GTF2E2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GTF2E2 gene promoter:
SRF SRF (504 AA) Bach2 NCX/Ncx MEF-2 POU3F2 MEF-2A Pax-3 IRF-2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GTF2E2 promoter sequence

Search SABiosciences Chromatin IP Primers for GTF2E2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF2E2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12

GTF2E2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2E2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M030429: view genomic region (about GC identifiers)

Start:	30,435,835 bp from pter	End:	30,515,768 bp from pter
Size:	79,934 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084 (See protein sequence)

Recommended Name: Transcription initiation factor IIE subunit beta

Size: 291 amino acids; 33044 Da

Subunit: Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H. Interacts with ATF7IP

Subcellular location: Nucleus

2 PDB 3D structures from and Proteopedia for GTF2E2:

1D8J (3D)

1D8K (3D)

Secondary accessions: D3DSV2 Q9H2B9

Explore the universe of human proteins at neXtProt for GTF2E2: NX_P29084

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P29084

GTF2E2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002086.1

ENSEMBL proteins:

ENSP00000348168 ENSP00000428981 ENSP00000429921 ENSP00000429312

Reactome Protein details: P29084
Human Recombinant Protein Products:

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	Uscn Proteins for GTF2E2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005673	transcription factor TFIIE complex	IEA	--
GO:0005737	cytoplasm	IDA	--

GTF2E2 for ontologies About GeneDecksing

GTF2E2 Antibody Products:

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	Uscn ELISAs and CLIAs for GTF2E2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GTF2E2 for domains About GeneDecksing

3 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR016656 TFIIE-bsu

IPR003166 TFIIE_bsu_DNA-bd

Graphical View of Domain Structure for InterPro Entry P29084

ProtoNet protein and cluster: P29084

1 Blocks protein family: IPB003166 Transcription factor TFIIE beta subunit

UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084

Similarity: Belongs to the TFIIE beta subunit family

Similarity: Contains 1 TFIIE beta DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: T2EB_HUMAN, P29084

Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and

DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Genatlas biochemistry entry for GTF2E2:

general transcription factor IIE,beta polypeptide (34kDa)

miRNA Products:		OriGene 3'-UTR Clone: GTF2E2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GTF2E2
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate GTF2E2 (see all 12):
		hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4268 hsa-miR-548y

		SwitchGear 3'UTR luciferase reporter plasmid: GTF2E2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		Search LifeMap BioReagents cell lines for GTF2E2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	--

GTF2E2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for GTF2E2:

Decreased viability

Increased G1 DNA content

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

8/13 pathways (see all 13)
RNA Polymerase II Pre-transcription Events	0.72	RNA Polymerase II Promoter Escape	0.40
Transcription of the HIV genome	0.70	RNA Polymerase II Transcription Initiation	0.40
RNA Polymerase II Transcription Initiation And Promoter Clearance	0.40	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition	0.40
HIV-1 Transcription Initiation	0.40	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.40

Assembly of RNA Polymerase-II Initiation Complex

Assembly of RNA Polymerase-II Initiation Complex	1.00	Basal transcription factors	0.49
Transcription of mRNA	0.91	Crosstalk Between CARM1 and ESRs	0.32
Protein Acetylation and Deacetylation	0.51

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

PEDF Induced Signaling

RAR-Gamma-RXR-Alpha Degradation

0.54

Glucocorticoid Receptor Signaling

0.27

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF2E2 (see all 9)

	Nuclear Receptor Activation by Vitamin-A
	Protein Acetylation and Deacetylation
	Androgen Signaling
	Glucocorticoid Receptor Signaling
	Estrogen Pathway

1 BioSystems Pathway for GTF2E2

Eukaryotic Transcription Initiation

5/19 Reactome Pathways for GTF2E2 (see all 19)

	Late Phase of HIV Life Cycle
	RNA Polymerase II Transcription
	RNA Polymerase II Transcription Initiation And Promoter Clearance
	Disease
	HIV Infection

1 Kegg Pathway (Kegg details for GTF2E2):

Basal transcription factors

GTF2E2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GTF2E2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for GTF2E2 (P29084^{1, 2, 3} ENSP00000348168⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GTF2E1	P29083²^,³, ENSP00000283875⁴	MINT-1894096 MINT-1894113 I2D: score=10 STRING: ENSP00000283875
GTF2F2	P13984³, ENSP00000340823⁴	I2D: score=3 STRING: ENSP00000340823
ATF7IP	Q6VMQ6³, ENSP00000261168⁴	I2D: score=2 STRING: ENSP00000261168
ERCC3	P19447³, ENSP00000285398⁴	I2D: score=2 STRING: ENSP00000285398
GTF2A1	P52655³, ENSP00000298173⁴	I2D: score=2 STRING: ENSP00000298173

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0006368	transcription elongation from RNA polymerase II promoter	TAS	--
GO:0010467	gene expression	TAS	--

GTF2E2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GTF2E2
Search CenterWatch for drugs/clinical trials and news about GTF2E2 / T2EB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GTF2E2 gene:

NM_002095.4

Unigene Cluster for GTF2E2:

General transcription factor IIE, polypeptide 2, beta 34kDa

Hs.77100 [show with all ESTs]

Unigene Representative Sequence: BC030572

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355904(uc003xig.3) ENST00000522833 ENST00000523499 ENST00000518599

ENST00000518445

miRNA Products:		OriGene 3'-UTR Clone: GTF2E2 Browse OriGene MicroRNA Expression Plasmids
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		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate GTF2E2 (see all 12):
		hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-4268 hsa-miR-548y

		SwitchGear 3'UTR luciferase reporter plasmid: GTF2E2 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF2E2

Additional cDNA sequence:

BC001775.1 BC030572.2 S67861.1 X63469.1

6 DOTS entries:

DT.87017043 DT.439726 DT.92431229 DT.100820125 DT.92431223 DT.92431228

24/242 AceView cDNA sequences (see all 242):

AW949391 BQ049799 W94196 BC030572 BP354300 BG108488 BE513765 AA553960

BM855206 CR606679 BM454383 AI890459 CK819595 BF196763 BM788842 AI049905

BU838437 BI493035 CB132338 CR626793 BM974223 NM_002095 AL517772 BU630090

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2E2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:																	-		-		-
SP2:
SP3:

ECgene alternative splicing isoforms for GTF2E2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GTF2E2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGTGTCTT

About this image

GTF2E2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GTF2E2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GTF2E2

SOURCE GeneReport for Unigene cluster: Hs.77100

SABiosciences Custom PCR Arrays for GTF2E2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GTF2E2 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gtf2e2^{1 , 5}	general transcription factor II E, polypeptide 2 (beta more^{1, 5}	90.49(n)¹ 94.5(a)¹		8 (20.79 cM)⁵ 68153¹ NM_001167921.1¹ NP_001161393.1¹ 33731914⁵
chicken (Gallus gallus)	Aves	GTF2E2¹	general transcription factor IIE, polypeptide 2, beta more	78.79(n) 82.87(a)		771227 XM_001233399.2 XP_001233400.1
lizard (Anolis carolinensis)	Reptilia	GTF2E2⁶	--	88(a)	1 ↔ 1	GL343257.1(537493-572520)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8438²	Xenopus laevis transcribed sequence with moderate similarity more	76.72(n)		CA981148.1
zebrafish (Danio rerio)	Actinopterygii	gtf2e2²	general transcription factor IIE, polypeptide 2, beta	74.28(n)		334854 CD760310.1
fruit fly (Drosophila melanogaster)	Insecta	TfIIE&bgr;³ TfIIEbeta¹	transcription initiation from Pol II promoter more³ Transcription factor IIEbeta¹	52(a)³ 57.09(n)¹ 58.55(a)¹		64B1³ 38527¹ NM_079199.3¹ NP_523923.1¹
worm (Caenorhabditis elegans)	Secernentea	F54D5.11³ CELE_F54D5.11¹	transcription intiation factor TFIIE-BETA³ Protein F54D5.11¹	36(a)³ 48.8(n)¹ 39.93(a)¹		II(11540627-11542229)³ 174765¹ NM_064065.5¹ NP_496466.1¹

ENSEMBL Gene Tree for GTF2E2 (if available)
TreeFam Gene Tree for GTF2E2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GTF2E2 gene

GTF2E2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GTF2E2
PGOHUM00000242863 PGOHUM00000241427

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185392913^1,2		--	30435724(+)	`CGATCC/TTTTAA`	1	--	int¹		0	--	--	--	--
rs147907821^1,2		--	30435734(+)	`ACCTCA/GTGATC`	1	--	int¹		0	--	--	--	--
rs147030567^1,2		--	30435806(+)	`ACTGAC/TGCTTC`	1	--	int¹		0	--	--	--	--
rs190318624^1,2		--	30435807(+)	`CTGACA/GCTTCT`	1	--	int¹		0	--	--	--	--
rs28687983^1,2		--	30435841(+)	`GACATC/TCAGCA`	1	--	int¹		2		CSA WA	120
rs182561081^1,2		--	30436099(+)	`CATTCA/GAGACT`	1	--	ut3¹		0	--	--	--	--
rs74948772^1,2	C,F,	--	30436265(+)	`TGAGCC/TCATTC`	1	--	ut3¹		1		WA	118
rs138179046^1,2		--	30436307(+)	`CACTTA/GTTTTG`	1	--	ut3¹		0	--	--	--	--
rs149215642^1,2		--	30436629(+)	`AGCATA/GCCCAG`	1	--	int¹		0	--	--	--	--
rs143397920^1,2		--	30436646(+)	`GTGGCC/TGAGGA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GTF2E2 (30435835 - 30515768 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for GTF2E2
4 CNVs: 95355 82552 82550 82551

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GTF2E2 for disorders           About GeneDecksing

OMIM gene information: 189964    OMIM disorders: --

3 diseases for GTF2E2:    About MalaCards

werner syndrome ulcerative colitis immunodeficiency

1 disease from the University of Copenhagen DISEASES database for GTF2E2:

Werner syndrome

Human Genome Epidemiology (HuGE) Navigator: GTF2E2 (1 document)

Export disorders for GTF2E2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GTF2E2 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with GTF2E2)

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Conserved sequence motifs in the small subunit of human general transcription factor TFIIE. (PubMed id 1956404)^{1, 2, 3} Sumimoto H....Roeder R.G. (1991)
MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)^{1, 2} Liu L....Nakao M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68. (PubMed id 10792464)^{1, 2} Kang S.-W.... Horikoshi M. (2000)
Structure and functional properties of human general transcription factor IIE. (PubMed id 1956398)^{1, 2} Peterson M.G.... Tjian R. (1991)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2961	HGNC: 4651	AceView: GTF2E2	Ensembl:ENSG00000197265	euGenes: HUgn2961
ECgene: GTF2E2	Kegg: 2961	H-InvDB: GTF2E2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GTF2E2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GTF2E2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GTF2E2 gene:
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GeneCards and IP:
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GTF2E2 Gene

general transcription factor IIE, polypeptide 2, beta 34kDa

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GTF2E2 Gene

general transcription factor IIE, polypeptide 2, beta 34kDa

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