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Aliases for GTF2E1 Gene

Aliases for GTF2E1 Gene

  • General Transcription Factor IIE Subunit 1 2 3 5
  • General Transcription Factor IIE, Polypeptide 1, Alpha 56kDa 2 3
  • Transcription Initiation Factor IIE Subunit Alpha 3 4
  • General Transcription Factor IIE 56 KDa Subunit 3 4
  • TFIIE Alpha Subunit 2 3
  • TFIIE-Alpha 3 4
  • TF2E1 3 4
  • General Transcription Factor IIE, Polypeptide 1 (Alpha Subunit, 56kD) 2
  • TFIIE-A 3
  • FE 3

External Ids for GTF2E1 Gene

Previous GeneCards Identifiers for GTF2E1 Gene

  • GC03P117106
  • GC03P120110
  • GC03P121742
  • GC03P121790
  • GC03P121952
  • GC03P120461
  • GC03P117835

Summaries for GTF2E1 Gene

GeneCards Summary for GTF2E1 Gene

GTF2E1 (General Transcription Factor IIE Subunit 1) is a Protein Coding gene. Diseases associated with GTF2E1 include trichothiodystrophy 1, photosensitive. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Epstein-Barr virus infection. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for GTF2E1 Gene

  • Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Gene Wiki entry for GTF2E1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2E1 Gene

Genomics for GTF2E1 Gene

Regulatory Elements for GTF2E1 Gene

Enhancers for GTF2E1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF2E1 on UCSC Golden Path with GeneCards custom track

Promoters for GTF2E1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF2E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF2E1 Gene

Chromosome:
3
Start:
120,742,637 bp from pter
End:
120,783,070 bp from pter
Size:
40,434 bases
Orientation:
Plus strand

Genomic View for GTF2E1 Gene

Genes around GTF2E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2E1 Gene

Proteins for GTF2E1 Gene

  • Protein details for GTF2E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29083-T2EA_HUMAN
    Recommended name:
    General transcription factor IIE subunit 1
    Protein Accession:
    P29083
    Secondary Accessions:
    • Q16103

    Protein attributes for GTF2E1 Gene

    Size:
    439 amino acids
    Molecular mass:
    49452 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with varicella-zoster virus IE63 protein.

    Three dimensional structures from OCA and Proteopedia for GTF2E1 Gene

neXtProt entry for GTF2E1 Gene

Proteomics data for GTF2E1 Gene at MOPED

Post-translational modifications for GTF2E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2E1 Gene

No data available for DME Specific Peptides for GTF2E1 Gene

Domains & Families for GTF2E1 Gene

Gene Families for GTF2E1 Gene

Suggested Antigen Peptide Sequences for GTF2E1 Gene

Graphical View of Domain Structure for InterPro Entry

P29083

UniProtKB/Swiss-Prot:

T2EA_HUMAN :
  • Contains 1 HTH TFE/IIEalpha-type domain.
  • Belongs to the TFIIE alpha subunit family.
Domain:
  • Contains 1 HTH TFE/IIEalpha-type domain.
Family:
  • Belongs to the TFIIE alpha subunit family.
genes like me logo Genes that share domains with GTF2E1: view

Function for GTF2E1 Gene

Molecular function for GTF2E1 Gene

GENATLAS Biochemistry:
general transcription factor IIE,alpha polypeptide (56kDa)
UniProtKB/Swiss-Prot Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Gene Ontology (GO) - Molecular Function for GTF2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with GTF2E1: view
genes like me logo Genes that share phenotypes with GTF2E1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2E1 Gene

Localization for GTF2E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2E1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2E1 Gene COMPARTMENTS Subcellular localization image for GTF2E1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GTF2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GTF2E1: view

Pathways & Interactions for GTF2E1 Gene

genes like me logo Genes that share pathways with GTF2E1: view

Gene Ontology (GO) - Biological Process for GTF2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter IEA,TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0016032 viral process IEA,TAS --
genes like me logo Genes that share ontologies with GTF2E1: view

No data available for SIGNOR curated interactions for GTF2E1 Gene

Drugs & Compounds for GTF2E1 Gene

No Compound Related Data Available

Transcripts for GTF2E1 Gene

Unigene Clusters for GTF2E1 Gene

General transcription factor IIE, polypeptide 1, alpha 56kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2E1 Gene

No ASD Table

Relevant External Links for GTF2E1 Gene

GeneLoc Exon Structure for
GTF2E1
ECgene alternative splicing isoforms for
GTF2E1

Expression for GTF2E1 Gene

mRNA expression in normal human tissues for GTF2E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF2E1 Gene

This gene is overexpressed in Lymph node (11.6) and Pancreas (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2E1 Gene



SOURCE GeneReport for Unigene cluster for GTF2E1 Gene Hs.445272

genes like me logo Genes that share expression patterns with GTF2E1: view

Protein tissue co-expression partners for GTF2E1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2E1 Gene

Orthologs for GTF2E1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2E1 35
  • 91.93 (n)
  • 94.75 (a)
GTF2E1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2E1 35
  • 92.85 (n)
  • 96.35 (a)
GTF2E1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2e1 35
  • 88.69 (n)
  • 92.94 (a)
Gtf2e1 36
  • 93 (a)
OneToOne
Gtf2e1 16
chimpanzee
(Pan troglodytes)
Mammalia GTF2E1 35
  • 99.24 (n)
  • 99.09 (a)
GTF2E1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2e1 35
  • 88.36 (n)
  • 92.69 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF2E1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2E1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2E1 35
  • 74.41 (n)
  • 81.09 (a)
GTF2E1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2E1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2e1 35
  • 66.74 (n)
  • 73.96 (a)
Str.637 35
African clawed frog
(Xenopus laevis)
Amphibia tfiiealpha-prov 35
zebrafish
(Danio rerio)
Actinopterygii gtf2e1 35
  • 67.43 (n)
  • 71.72 (a)
gtf2e1 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TfIIEalpha 37
  • 45 (a)
TfIIEalpha 35
  • 49.59 (n)
  • 48.77 (a)
TfIIEalpha 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006355 35
  • 50.57 (n)
  • 46.08 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK550.4 37
  • 27 (a)
CELE_ZK550.4 35
  • 46.76 (n)
  • 33.22 (a)
ZK550.4 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFA1 36
  • 21 (a)
OneToOne
TFA1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for GTF2E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2E1 Gene

ENSEMBL:
Gene Tree for GTF2E1 (if available)
TreeFam:
Gene Tree for GTF2E1 (if available)

Paralogs for GTF2E1 Gene

No data available for Paralogs for GTF2E1 Gene

Variants for GTF2E1 Gene

Sequence variations from dbSNP and Humsavar for GTF2E1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs378759 -- 120,766,862(-) GGACA(C/T)GGAAA intron-variant
rs1056195 -- 120,782,238(+) GCTTA(G/T)AATTT utr-variant-3-prime
rs1070298 -- 120,760,657(-) aaagg(C/T)ctttg intron-variant
rs447978 -- 120,772,239(+) TGGCT(A/G)CAATT intron-variant
rs1466960 -- 120,746,775(+) tctgg(A/G)caaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2E1 Gene

Variant ID Type Subtype PubMed ID
nsv829699 CNV Loss 17160897
nsv877378 CNV Gain 21882294
nsv829700 CNV Gain+Loss 17160897
nsv507121 CNV Insertion 20534489

Variation tolerance for GTF2E1 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2E1 Gene

HapMap Linkage Disequilibrium report
GTF2E1
Human Gene Mutation Database (HGMD)
GTF2E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2E1 Gene

Disorders for GTF2E1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF2E1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trichothiodystrophy 1, photosensitive
  • amish brittle hair brain syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GTF2E1

Genetic Association Database (GAD)
GTF2E1
Human Genome Epidemiology (HuGE) Navigator
GTF2E1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2E1
genes like me logo Genes that share disorders with GTF2E1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF2E1 Gene

Publications for GTF2E1 Gene

  1. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PMID: 19106100) Liu L. … Nakao M. (J. Biol. Chem. 2009) 3 4 67
  2. p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. (PMID: 18160537) Di Lello P. … Omichinski J.G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PMID: 8162052) Heng H.H. … Tsui L.C. (Hum. Mol. Genet. 1994) 2 3
  4. Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences. (PMID: 1454543) Ohkuma Y. … Horikoshi M. (Nucleic Acids Res. 1992) 2 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for GTF2E1 Gene

Sources for GTF2E1 Gene

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