GTF2E1 Gene
protein-coding GIFtS: 59
GCID: GC03P120461
|
|
general transcription factor IIE, polypeptide 1, alpha 56kDa(Previous names: general transcription factor IIE, polypeptide 1 (alpha...)
| |
Aliases
for GTF2E1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| General Transcription Factor IIE, Polypeptide 1, Alpha 56kDa1 2 | | TF2E12 3 | | FE1 2 | | TFIIE-Alpha1 | | TFIIE-A1 2 | | General Transcription Factor IIE, Polypeptide 1 (Alpha Subunit, 56kD)1 | | General Transcription Factor IIE 56 KDa Subunit2 3 | | General Transcription Factor IIE Subunit 12 | | Transcription Initiation Factor IIE Subunit Alpha2 3 | | |
Export aliases for GTF2E1 gene to outside databasesPrevious GC identifers: GC03P117106 GC03P120110 GC03P121742 GC03P121790 GC03P121952 GC03P117835 |
Summaries
for GTF2E1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase andDNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase
Gene Wiki entry for GTF2E1
|
Genomic Views
for GTF2E1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GTF2E1 gene promoter:
c-Fos AP-1 AML1a LUN-1 HNF-4alpha2 HNF-4alpha1 S8 ZID TGIF Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for GTF2E1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF2E1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21-q24 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q21-q24GTF2E1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P120461: view genomic region
(about GC identifiers)
Start:
|
120,461,484 bp from pter |
End:
|
120,501,916 bp from pter |
Size:
|
40,433 bases |
Orientation:
|
plus strand |
|
Proteins
for GTF2E1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083 (See
protein sequence)Recommended Name: General transcription factor IIE subunit 1 Size: 439 amino acids; 49452 Da
Subunit: Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts withvaricella-zoster virus IE63 protein
Subcellular location: Nucleus
4 PDB 3D structures from  and Proteopedia  for GTF2E1:1VD4 (3D)
2JTX (3D)
2RNQ (3D)
2RNR (3D)
Secondary accessions: Q16103Explore the universe of human proteins at neXtProt for GTF2E1: NX_P29083
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P29083
GTF2E1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005504.2
ENSEMBL proteins: ENSP00000417342 ENSP00000418808 ENSP00000283875 ENSP00000417077 Reactome Protein details: P29083
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- |
GTF2E1 for ontologies About GeneDecksing
GTF2E1 Antibody Products:
Assay Products for GTF2E1: |
Protein
Domains /
Families
for GTF2E1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GTF2E1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P29083ProtoNet protein and cluster: P29083 1 Blocks protein family: IPB002853 Transcription factor TFIIE
UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083Similarity: Belongs to the TFIIE alpha subunit familySimilarity: Contains 1 HTH TFE/IIEalpha-type domain |
Function
for GTF2E1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase andDNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase Genatlas biochemistry entry for GTF2E1:general transcription factor IIE,alpha polypeptide (56kDa)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF2E1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
GTF2E1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GTF2E1:
|
Pathways & Interactions
for GTF2E1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | Assembly of RNA Polymerase-II Initiation Complex | | | 3 | Late Phase of HIV Life Cycle | | | 4 | Transcription | | | 5 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF2E1 (see all 9)
1  BioSystems Pathway for GTF2E1
5/19 
Reactome Pathways for GTF2E1 (see all 19)
1 
Kegg Pathway (Kegg details for GTF2E1):
GTF2E1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GTF2E1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/63 Interacting proteins for GTF2E1 (P290832, 3 ENSP000002838754) via UniProtKB, MINT, STRING, and/or I2D (see all 63)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0006368 | transcription elongation from RNA polymerase II promoter |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- |
GTF2E1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GTF2E1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GTF2E1
Search CenterWatch for drugs/clinical trials and news about GTF2E1 / T2EA
|
Transcripts
for GTF2E1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GTF2E1 gene: NM_005513.2 Unigene Cluster for GTF2E1: General transcription factor IIE, polypeptide 1, alpha 56kDa Hs.445272 [show with all ESTs]Unigene Representative Sequence: NM_0055135 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484715 ENST00000469772 ENST00000283875(uc003edz.4) ENST00000492959
ENST00000497393
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GTF2E1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GTF2E1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GTF2E1 (NM_005513) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK223401.1 BC005917.1 S67859.1 X63468.1 4 DOTS entries: DT.120868996 DT.95261900 DT.95261902 DT.412523 24/39 AceView cDNA sequences (see all 39): BP343126 AL135122 BE844117 AA424864 AW148448 AW291752 AA243767 BG571275 AA455964 BX102240 AI800655 BU954321 X63468 AA243782 BE786346 BC005917 BX472687 BF349423 NM_005513 AI167580 AI039366 AA453363 AI038742 AA309888
GeneLoc Exon Structure
|
Expression
for GTF2E1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GTF2E1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAGAATAT
About this image
See GTF2E1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GTF2E1
SOURCE GeneReport for Unigene cluster: Hs.445272
SABiosciences Custom PCR Arrays for GTF2E1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GTF2E1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GTF2E1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GTF2E1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GTF2E1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E1 |
Orthologs
for GTF2E1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GTF2E1 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gtf2e11 , 5 |
general transcription factor II E, polypeptide 1 (alpha more1, 5 |
88.69(n)1
92.94(a)1 |
|
16 (26.38 cM)5
741971 NM_028812.31 NP_083088.11
375097905 |
chicken
(Gallus gallus) |
Aves |
GTF2E11 |
general transcription factor IIE, polypeptide 1, alpha more |
74.87(n)
81.55(a) |
|
418328 XM_416551.3 XP_416551.2 |
lizard
(Anolis carolinensis) |
Reptilia |
GTF2E16 |
-- |
74(a) |
1 ↔ 1 |
GL343473.1(682688-691420) |
African clawed frog
(Xenopus laevis) |
Amphibia |
tfiiealpha-prov2 |
general transcription factor II E, polypeptide 1 (alpha more |
75.42(n) |
|
BC043774.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gtf2e11 |
general transcription factor IIE, polypeptide 1, alpha |
68.81(n)
73.56(a) |
|
567899 NM_001045145.1 NP_001038610.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
TfIIEalpha1 , 3 |
transcription initiation from Pol II
promoter more3
Transcription factor IIEalpha1 |
45(a)3
50.08(n)1
49.02(a)1 |
|
68D23
393131 NM_079302.31 NP_524026.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK550.43
CELE_ZK550.41 |
Protein ZK550.41 |
27(a)3
43.9(n)1
29.48(a)1 |
|
IV(17255458-17257392)3
1785021 NM_070659.51 NP_503060.11 |
ENSEMBL Gene Tree for GTF2E1 (if available)
TreeFam Gene Tree for GTF2E1 (if available) |
Paralogs
for GTF2E1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GTF2E1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GTF2E1 (120461484 - 120501916 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GTF2E1: --
Human Gene Mutation Database (HGMD): GTF2E1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GTF2E1 |
|
Disorders
/ Diseases
for GTF2E1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GTF2E1 for disorders About GeneDecksing
OMIM gene information: 189962
OMIM disorders: --
3  diseases for GTF2E1: About MalaCardssporadic breast cancer breast cancer immunodeficiency
Human Genome Epidemiology (HuGE) Navigator: GTF2E1 (2 documents)
Export disorders for GTF2E1 gene to outside databases
|
Publications
for GTF2E1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GTF2E1 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with GTF2E1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)1, 2 Liu L....Nakao M. (2009)
- Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)1, 2 Hisatake K.... Roeder R.G. (1995)
- Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PubMed id 8162052)1, 3 Heng H.H....Tsui L.C. (1994)
- Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences. (PubMed id 1454543)1, 3 Ohkuma Y....Horikoshi M. (1992)
- Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE. (PubMed id 1956403)1, 2 Ohkuma Y....Roeder R.G. (1991)
- Structure and functional properties of human general transcription factor IIE. (PubMed id 1956398)1, 2 Peterson M.G.... Tjian R. (1991)
- p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. (PubMed id 18160537)1, 9 Di Lello P....Omichinski J.G. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for GTF2E1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GTF2E1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GTF2E1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GTF2E1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GTF2E1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GTF2E1 gene:
Search GeneIP for patents involving GTF2E1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GTF2E1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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