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GTF2E1 Gene

protein-coding   GIFtS: 63
GCID: GC03P120461

General Transcription Factor IIE, Polypeptide 1, Alpha 56kDa

(Previous names: general transcription factor IIE, polypeptide 1 (alpha subunit,...)
  See GTF2E1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
General Transcription Factor IIE, Polypeptide 1, Alpha 56kDa1 2     General Transcription Factor IIE, Polypeptide 1 (Alpha Subunit, 56kD)1
TF2E12 3 5     FE2
General Transcription Factor IIE 56 KDa Subunit2 3     TFIIE-A2
Transcription Initiation Factor IIE Subunit Alpha2 3     General Transcription Factor IIE Subunit 12
TFIIE-alpha2 3     

External Ids:    HGNC: 46501   Entrez Gene: 29602   Ensembl: ENSG000001537677   OMIM: 1899625   UniProtKB: P290833   

Export aliases for GTF2E1 gene to outside databases

Previous GC identifers: GC03P117106 GC03P120110 GC03P121742 GC03P121790 GC03P121952 GC03P117835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GTF2E1 Gene:
GTF2E1 (general transcription factor IIE, polypeptide 1, alpha 56kDa) is a protein-coding gene. Diseases associated with GTF2E1 include richter's syndrome. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083
Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase
and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA
polymerase

Gene Wiki entry for GTF2E1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2E1 gene promoter:
         c-Fos   AP-1   AML1a   LUN-1   HNF-4alpha2   HNF-4alpha1   S8   ZID   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2E1 promoter sequence
   Search Chromatin IP Primers for GTF2E1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q24   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q21-q24

GTF2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2E1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P120461:  view genomic region     (about GC identifiers)

Start:
120,461,484 bp from pter      End:
120,501,916 bp from pter
Size:
40,433 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083 (See protein sequence)
Recommended Name: General transcription factor IIE subunit 1  
Size: 439 amino acids; 49452 Da
Subunit: Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts
with varicella-zoster virus IE63 protein
4 PDB 3D structures from and Proteopedia for GTF2E1:
1VD4 (3D)        2JTX (3D)        2RNQ (3D)        2RNR (3D)    
Secondary accessions: Q16103

Explore the universe of human proteins at neXtProt for GTF2E1: NX_P29083

Explore proteomics data for GTF2E1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GTF2E1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005504.2  
    ENSEMBL proteins: 
     ENSP00000417342   ENSP00000418808   ENSP00000283875   ENSP00000417077  
    Reactome Protein details: P29083

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors

    Selected InterPro protein domains (see all 6):
     IPR013083 Znf_RING/FYVE/PHD
     IPR002853 TFIIE_asu
     IPR021600 TFIIE_asu_C
     IPR017919 TFIIE/TFIIEa_HTH
     IPR013137 Znf_TFIIB

    Graphical View of Domain Structure for InterPro Entry P29083

    ProtoNet protein and cluster: P29083

    1 Blocks protein domain: IPB002853 Transcription factor TFIIE

    UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083
    Similarity: Belongs to the TFIIE alpha subunit family
    Similarity: Contains 1 HTH TFE/IIEalpha-type domain


    Find genes that share domains with GTF2E1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2EA_HUMAN, P29083
    Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase
    and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA
    polymerase

         Genatlas biochemistry entry for GTF2E1:
    general transcription factor IIE,alpha polypeptide (56kDa)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16547462
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with GTF2E1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GTF2E1:
     Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2E1
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    miRNA
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    miRTarBase miRNAs that target GTF2E1:
    hsa-mir-24-3p (MIRT030375), hsa-mir-361-5p (MIRT020098), hsa-mir-221-3p (MIRT024145), hsa-let-7f-5p (MIRT051392)

    Block miRNA regulation of human, mouse, rat GTF2E1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GTF2E1 (see all 22):
    hsa-miR-148b* hsa-miR-361-5p hsa-miR-3673 hsa-miR-300 hsa-miR-429 hsa-miR-624 hsa-miR-221 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidGTF2E1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat GTF2E1

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2EA_HUMAN, P29083: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with GTF2E1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF2E1 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    Glucocorticoid Receptor Signaling0.43
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57


    Find genes that share SuperPaths with GTF2E1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2E1 (see all 9)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 BioSystems Pathway for GTF2E1
        Eukaryotic Transcription Initiation

    Selected Reactome Pathways for GTF2E1 (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    3 Kegg Pathways  (Kegg details for GTF2E1):
        Basal transcription factors
    Epstein-Barr virus infection
    Viral carcinogenesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF2E1
    Interactions:

        Search GeneGlobe Interaction Network for GTF2E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2E1 (P290831, 2, 3 ENSP000002838754) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2H1P327801, 2, 3, ENSP000002659634EBI-5462215,EBI-715539 MINT-6543860 MINT-6544144 MINT-6543809 MINT-6543875 MINT-6544058 MINT-6544043 MINT-6544016 MINT-6543846 MINT-6544109 MINT-6543950 MINT-6543970 MINT-6544074 MINT-6544091 MINT-6543893 MINT-6543913 MINT-6543931 MINT-6543998 MINT-6543827 MINT-6544126 I2D: score=3 STRING: ENSP00000265963
    ENSG00000224145Q9C0193, ENSP000003982244I2D: score=1 STRING: ENSP00000398224
    ENSG00000137384Q9C0193I2D: score=1 
    ENSG00000227147Q9C0193I2D: score=1 
    ENSG00000233599Q9C0193I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with GTF2E1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2E1 (T2EA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GTF2E1 gene: 
    NM_005513.2  

    Unigene Cluster for GTF2E1:

    General transcription factor IIE, polypeptide 1, alpha 56kDa
    Hs.445272  [show with all ESTs]
    Unigene Representative Sequence: NM_005513
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484715 ENST00000469772 ENST00000283875(uc003edz.4) ENST00000492959
    ENST00000497393
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GTF2E1 (see all 22):
    hsa-miR-148b* hsa-miR-361-5p hsa-miR-3673 hsa-miR-300 hsa-miR-429 hsa-miR-624 hsa-miR-221 hsa-miR-550a*
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      QuantiTect SYBR Green Assays in human, mouse, rat GTF2E1
      QuantiFast Probe-based Assays in human, mouse, rat GTF2E1

    Additional mRNA sequence: 

    AK223401.1 BC005917.1 S67859.1 X63468.1 

    4 DOTS entries:

    DT.120868996  DT.95261900  DT.95261902  DT.412523 

    Selected AceView cDNA sequences (see all 39):

    AW148448 AA455964 BP343126 AI800655 BX102240 BE844117 AL135122 AA243767 
    AA424864 AW291752 BG571275 AI039366 BF349423 AA243782 AI038742 BC005917 
    BE786346 AA455437 AI167580 S67859 AA778149 AA453363 BF591217 BU954321 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF2E1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGAATAT
    GTF2E1 Expression
    About this image


    GTF2E1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    GTF2E1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2E1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445272
        Custom PCR Arrays for GTF2E1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2E1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GTF2E1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2e11 , 5 general transcription factor II E, polypeptide 1 (alpha more1, 5 88.69(n)1
    92.94(a)1
      16 (26.38 cM)5
    741971  NM_028812.31  NP_083088.11 
     375097905 
    chicken
    (Gallus gallus)
    Aves GTF2E11 general transcription factor IIE, polypeptide 1, alpha more 74.41(n)
    81.09(a)
      418328  XM_416551.4  XP_416551.2 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2E16
    general transcription factor IIE, polypeptide 1, a...
    74(a)
    1 ↔ 1
    GL343473.1(682690-696203)
    African clawed frog
    (Xenopus laevis)
    Amphibia tfiiealpha-prov2 general transcription factor II E, polypeptide 1 (alpha more 75.42(n)    BC043774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gtf2e11 general transcription factor IIE, polypeptide 1, alpha 67.43(n)
    71.72(a)
      567899  NM_001045145.1  NP_001038610.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIEalpha1 , 3 transcription initiation from Pol II
    promoter more3
    Transcription factor IIEalpha1
    45(a)3
    49.59(n)1
    48.77(a)1
      68D23
    393131  NM_079302.41  NP_524026.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK550.43
    CELE_ZK550.41
    CELE_ZK550.41 27(a)3
    46.76(n)1
    33.22(a)1
      IV(17255458-17257392)3
    1785021  NM_070659.61  NP_503060.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TFA1(YKL028W)4 TFIIE large subunit, involved in recruitment of RNA more   --   11(385758-387206) 853840  NP_012897.1 


    ENSEMBL Gene Tree for GTF2E1 (if available)
    TreeFam Gene Tree for GTF2E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GTF2E1 (see all 687)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142804681,2
    F--120463426(+) AACAGA/TGAGCT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1156219551,2
    F--120463468(+) ATCCAA/GTATAT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1808305961,2
    --120463741(+) TTCATA/TCATTA 1 -- int10--------
    rs358066121,2
    C--120463774(+) TTTTT-/TGAGGG 1 -- int10--------
    rs800655011,2
    C--120463774(+) AATCAC/TTTTTT 1 -- int10--------
    rs1842845991,2
    --120463966(+) CTTGTC/TTTCAA 1 -- int10--------
    rs1484582461,2
    --120464040(+) CACTGA/TAGCCA 1 -- int10--------
    rs573781151,2
    C,F--120464104(+) TCTGAG/CGTCAG 1 -- int12Minor allele frequency- C:0.10WA 120
    rs353688901,2
    C--120464167(+) TAAAGT/GCCTCA 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1464704471,2
    --120464254(+) ACAGGG/TACCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GTF2E1 (120461484 - 120501916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GTF2E1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507121CNV Insertion20534489
    nsv829699CNV Loss17160897
    nsv877378CNV Gain21882294
    nsv829700CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): GTF2E1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF2E1
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF2E1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189962    OMIM disorders: --

    1 disease for GTF2E1:    
    About MalaCards
    richter's syndrome


    Find genes that share disorders with GTF2E1           About GenesLikeMe

    Genetic Association Database (GAD): GTF2E1
    Human Genome Epidemiology (HuGE) Navigator: GTF2E1 (2 documents)

    Export disorders for GTF2E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF2E1 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with GTF2E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    2. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)1, 2 Liu L.... Nakao M. (J. Biol. Chem. 2009)
    3. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)1, 2 Hisatake K.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    4. Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PubMed id 8162052)1, 3 Heng H.H....Tsui L.C. (Hum. Mol. Genet. 1994)
    5. Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences. (PubMed id 1454543)1, 3 Ohkuma Y....Horikoshi M. (Nucleic Acids Res. 1992)
    6. Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE. (PubMed id 1956403)1, 2 Ohkuma Y....Roeder R.G. (Nature 1991)
    7. Structure and functional properties of human general transcription factor IIE. (PubMed id 1956398)1, 2 Peterson M.G.... Tjian R. (Nature 1991)
    8. p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. (PubMed id 18160537)1, 9 Di Lello P....Omichinski J.G. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2960 HGNC: 4650 AceView: GTF2E1 Ensembl:ENSG00000153767 euGenes: HUgn2960
    ECgene: GTF2E1 Kegg: 2960 H-InvDB: GTF2E1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF2E1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF2E1 gene:
    Search GeneIP for patents involving GTF2E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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