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GTF2B Gene

protein-coding   GIFtS: 66
GCID: GC01M089318

General Transcription Factor IIB

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
General Transcription Factor IIB1 2     S300-II2 3
TF2B2 3 5     RNA Polymerase II Transcription Factor IIB2
TFIIB2 3 5     Transcription Initiation Factor IIB2
General Transcription Factor TFIIB2 3     

External Ids:    HGNC: 46481   Entrez Gene: 29592   Ensembl: ENSG000001379477   OMIM: 1899635   UniProtKB: Q004033   
ORGUL members:         

Export aliases for GTF2B gene to outside databases

Previous GC identifers: GC01M089795 GC01M088488 GC01M088655 GC01M088785 GC01M089030 GC01M087435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GTF2B Gene:
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription
initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex)
with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which
initially recognizes the promoter sequence, and RNA polymerase II. (provided by RefSeq, Jul 2008)

GeneCards Summary for GTF2B Gene:
GTF2B (general transcription factor IIB) is a protein-coding gene. GO annotations related to this gene include core promoter binding and transcription factor binding.

UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403
Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA
polymerase II

Gene Wiki entry for GTF2B (Transcription factor II B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2B gene promoter:
         TBP   AP-1   TFIID   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2B promoter sequence
   Search Chromatin IP Primers for GTF2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22-p21   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22-p21

GTF2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M089318:  view genomic region     (about GC identifiers)

Start:
89,318,321 bp from pter      End:
89,357,627 bp from pter
Size:
39,307 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403 (See protein sequence)
Recommended Name: Transcription initiation factor IIB  
Size: 316 amino acids; 34833 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by
polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with
GPBP1 (By similarity). Interacts with Epstein-Barr virus EBNA2
Selected PDB 3D structures from and Proteopedia for GTF2B (see all 7):
1C9B (3D)        1DL6 (3D)        1RLY (3D)        1RO4 (3D)        1TFB (3D)        1VOL (3D)    
Secondary accessions: A8K1A7 Q5JS30

Explore the universe of human proteins at neXtProt for GTF2B: NX_Q00403

Explore proteomics data for GTF2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys100, Lys178
  • Modification sites at PhosphoSitePlus

  • See GTF2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001505.1  
    ENSEMBL proteins: 
     ENSP00000359531   ENSP00000415741   ENSP00000402345  
    Reactome Protein details: Q00403

    GTF2B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GTF2B

     
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    antibodies-online proteins for GTF2B (21 products) 

     
    antibodies-online peptides for GTF2B

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    antibodies-online antibodies for GTF2B (72 products) 

    GTF2B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors

    5 InterPro protein domains:
     IPR023486 TFIIB_CS
     IPR000812 TFIIB
     IPR013763 Cyclin-like
     IPR013150 TFIIB_cyclin
     IPR013137 Znf_TFIIB

    Graphical View of Domain Structure for InterPro Entry Q00403

    ProtoNet protein and cluster: Q00403

    3 Blocks protein domains:
    IPB000812 Transcription factor TFIIB family
    IPB006670 Cyclin
    IPB013137 Zinc finger


    UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403
    Similarity: Belongs to the TFIIB family
    Similarity: Contains 1 TFIIB-type zinc finger


    Find genes that share domains with GTF2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF2B_HUMAN, Q00403
    Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA
    polymerase II

         Genatlas biochemistry entry for GTF2B:
    general transcription factor IIB,35 kDa

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IEA--
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI10330164
    GO:0008134transcription factor binding IPI9722567
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with GTF2B           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for GTF2B:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         1 MGI phenotypic allele for Gtf2b (no phenotypes)

    Find genes that share phenotypes with GTF2B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2B
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    miRNA
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    hsa-mir-122-5p (MIRT003079), hsa-mir-484 (MIRT041771)

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    Selected qRT-PCR Assays for microRNAs that regulate GTF2B (see all 13):
    hsa-miR-3671 hsa-miR-607 hsa-miR-206 hsa-miR-3673 hsa-miR-187* hsa-miR-1283 hsa-miR-548v hsa-miR-222
    SwitchGear 3'UTR luciferase reporter plasmidGTF2B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TF2B_HUMAN, Q00403: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with GTF2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF2B About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    Glucocorticoid Receptor Signaling0.43
    5CREB Pathway
    CREB Pathway0.68


    Find genes that share SuperPaths with GTF2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2B (see all 11)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 Cell Signaling Technology (CST) Pathway for GTF2B
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for GTF2B
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for GTF2B
        Eukaryotic Transcription Initiation


    Selected Reactome Pathways for GTF2B (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    3 Kegg Pathways  (Kegg details for GTF2B):
        Basal transcription factors
    Epstein-Barr virus infection
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including GTF2B: 
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GTF2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2B (Q004031, 2, 3 ENSP000003595314) via UniProtKB, MINT, STRING, and/or I2D (see all 280)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042062, 3, ENSP000003842734MINT-62398 MINT-62399 I2D: score=4 STRING: ENSP00000384273
    CREBBPQ927932, 3, ENSP000002623674MINT-6665325 I2D: score=4 STRING: ENSP00000262367
    GTF2H4Q927593, ENSP000002598954I2D: score=1 STRING: ENSP00000259895
    ENSG00000221974Q927593I2D: score=1 
    ENSG00000226384Q927593I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-templated transcription, initiation ----
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with GTF2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2B (TF2B)

    Selected Novoseek inferred chemical compound relationships for GTF2B gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tbps 60.6 1 12446790 (1)
    1,25 dihydroxy vitamin d3 43.7 1 9013769 (1)
    zinc 40.4 24 18631123 (3), 7891725 (2), 9013769 (2), 14536083 (2) (see all 13)
    phosphodiester 31 2 10872452 (1), 8631733 (1)
    vitamin d 25.3 5 12520521 (1), 9379138 (1), 9013769 (1), 12529369 (1) (see all 5)
    retinoic acid 4.49 2 9808423 (1), 8887661 (1)
    atp 0 1 8631733 (1)
    estradiol 0 2 15079859 (1)
    steroid 0 2 9379138 (1), 8990171 (1)
    proline 0 1 9089417 (1)



    Find genes that share compounds with GTF2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GTF2B gene: 
    NM_001514.5  

    Unigene Cluster for GTF2B:

    General transcription factor IIB
    Hs.481852  [show with all ESTs]
    Unigene Representative Sequence: NM_001514
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370500(uc001dmo.4 uc009wcw.1) ENST00000448623 ENST00000494819
    ENST00000418217 ENST00000486078 ENST00000471296 ENST00000471471
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    hsa-miR-3671 hsa-miR-607 hsa-miR-206 hsa-miR-3673 hsa-miR-187* hsa-miR-1283 hsa-miR-548v hsa-miR-222
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    Additional mRNA sequence: 

    AB451296.1 AK289822.1 BC020597.1 M76766.1 S44184.1 

    8 DOTS entries:

    DT.217227  DT.92437115  DT.100651698  DT.95270437  DT.92437109  DT.92437111  DT.92437112  DT.100668090 

    Selected AceView cDNA sequences (see all 246):

    AI948700 BI761841 BX488793 AA195519 AI803543 AI167866 BQ637247 CR619060 
    BC020597 BX107185 AL546491 CR592227 CB161485 BP379342 U47720 NM_001514 
    BF432599 AA313473 F02944 BU182783 AA031866 CR598774 BF438221 BM314476 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
    SP1:                          -                             -     -                     
    SP2:                          -                                                         
    SP3:                    -     -                                                         
    SP4:                          -     -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for GTF2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GTF2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACGCATTC
    GTF2B Expression
    About this image


    GTF2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebral Cortex
    GTF2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481852
        Pathway & Disease-focused RT2 Profiler PCR Array including GTF2B: 
              Transcription Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GTF2B gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2b1 , 5 general transcription factor IIB1, 5 89.98(n)1
    99.68(a)1
      3 (66.69 cM)5
    2299061  NM_145546.11  NP_663521.11 
     1427652475 
    chicken
    (Gallus gallus)
    Aves GTF2B1 general transcription factor IIB 85.55(n)
    97.78(a)
      424518  XM_422356.4  XP_422356.3 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2B6
    general transcription factor IIB
    97(a)
    1 ↔ 1
    4(95880146-95907992)
    African clawed frog
    (Xenopus laevis)
    Amphibia gtf2b-A2 general transcription factor IIB 79.98(n)    X62868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc44c112 wufc44c11 78.48(n)   324823  BC055569.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIB1 , 3 transcription initiation from Pol II
    promoter more3
    Transcription factor IIB1
    79(a)3
    65.71(n)1
    79.37(a)1
      344301  NM_001273420.11  NP_001260349.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ttb-11 , 3 transcription factor3
    ttb-11
    61(a)3
    60.67(n)1
    62.33(a)1
      V(156222-157373)3
    1785441  NM_070745.41  NP_503146.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUA7(YPR086W)4
    SUA71
    Transcription factor TFIIB, a general transcription more4
    SUA71
    48.15(n)1
    38.71(a)1
      16(710101-711138)4
    8562011, 4  NP_015411.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TFIIB1 TFIIB 55.64(n)
    49.28(a)
      818761  NM_129726.3  NP_181694.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05348001 Os09g0534800 53.78(n)
    49.65(a)
      4347689  NM_001070310.1  NP_001063775.1 


    ENSEMBL Gene Tree for GTF2B (if available)
    TreeFam Gene Tree for GTF2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for GTF2B (see all 903)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357224
    A colorectal cancer sample4--see VAR_0357222 R Q mis40--------
    rs348086161,2
    C--89334424(+) TATTC-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1833341291,2
    --89339497(+) TTAGGA/CCAGAT 1 -- ds50010--------
    rs1114303691,2
    C,F--89339504(+) AGATGG/AGGGCT 1 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs1422039451,2
    C--89339512(+) GCTCAC/TGCCTC 1 -- ds50010--------
    rs1885409941,2
    --89339546(+) AAGGCA/CGGTGG 1 -- ds50010--------
    rs801389631,2
    C--89339547(+) AGGCAC/GGTGGA 1 -- ds50010--------
    rs1478538861,2
    --89339595(+) CATGGC/TGAAAC 1 -- ds50010--------
    rs1397997201,2
    C--89339768(+) ACAGAC/GCAAGA 1 -- ds50010--------
    rs1445937681,2
    --89339778(+) ACTCTC/GTATCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GTF2B (89318321 - 89357627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GTF2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830525CNV Loss17160897
    nsv462472CNV Loss19166990
    nsv830514CNV Loss17160897
    dgv22n27CNV Gain19166990
    nsv830537CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GTF2B
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189963    OMIM disorders: --


    Find genes that share disorders with GTF2B           About GenesLikeMe

    6 Novoseek inferred disease relationships for GTF2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 39.7 8 14764096 (1), 7791769 (1), 8972203 (1), 11371188 (1) (see all 7)
    retinoblastoma 36 3 9433129 (1), 8628726 (1), 8434021 (1)
    carcinoma embryonal 10.9 2 7878015 (1), 8887661 (1)
    immunodeficiency 3.52 3 7707528 (1), 8800208 (1), 9292011 (1)
    tumors 0.441 1 8628726 (1)
    shock 0 5 16330756 (2), 17994014 (1), 11005381 (1), 15149597 (1)


    Export disorders for GTF2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF2B gene, integrated from 10 sources (see all 360):
    (articles sorted by number of sources associating them with GTF2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human gene encoding the general transcription initiation factor IIB. (PubMed id 1876184)1, 2, 3, 9 Ha I.... Reinberg D. (Nature 1991)
    2. The HIV-1 Vpr co-activator induces a conformational change in TFIIB. (PubMed id 10359081)1, 2, 9 Agostini I.... Sire J. (FEBS Lett. 1999)
    3. Sequence of general transcription factor TFIIB and relationships to other initiation factors. (PubMed id 1946368)1, 2, 9 Malik S.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    4. Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. (PubMed id 11045620)1, 2, 9 Chen H.T.... Scott R.A. (Protein Sci. 2000)
    5. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. (PubMed id 7671313)1, 2, 9 Bagby S.... Ikura M. (Cell 1995)
    6. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. (PubMed id 8800208)1, 2, 9 Agostini I....Sire J. (J. Mol. Biol. 1996)
    7. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. (PubMed id 7675079)1, 2, 9 Nikolov D.B.... Burley S.K. (Nature 1995)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. (PubMed id 8566795)1, 2 Umehara T.... Horikoshi M. (Gene 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2959 HGNC: 4648 AceView: GTF2B Ensembl:ENSG00000137947 euGenes: HUgn2959
    ECgene: GTF2B Kegg: 2959 H-InvDB: GTF2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF2B gene:
    Search GeneIP for patents involving GTF2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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