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GTF2B Gene

protein-coding GIFtS: 65

GC01M089030

general transcription factor IIB
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000012347 ^²
OTTHUMP00000058838 ^²
S300-II ^³
TF2B ^², ³, ⁵
TFIIB ^¹, ², ³, ⁵

Descriptions
General transcription factor TFIIB ^³
RNA polymerase II transcription factor IIB ^²
general transcription factor IIB ^²

External Ids
HGNC: 4648¹
Entrez Gene: 2959²
UniProtKB: Q00403³
Ensembl: ENSG00000137947⁷

Search outside databases for aliases for GTF2B gene

Previous GC identifers: GC01M089795 GC01M088488 GC01M088655 GC01M088785

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GTF2B:

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for

transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms

a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB

serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and

RNA polymerase II. [provided by RefSeq]

UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403

Function: General factor that plays a major role in the activation of eukaryotic genes transcribed

by RNA polymerase II

Gene Wiki entry for GTF2B (Transcription_Factor_II_B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GTF2B gene

Entrez Gene cytogenetic band: 1p22-p21 Ensembl cytogenetic band: 1p22.2 HGNC cytogenetic band: 1p22-p21

GTF2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M089030: (about GC identifiers)

Start:	89,090,909 bp from pter
End:	89,129,889 bp from pter
Size:	38,981 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403 (See protein sequence)

Recommended Name: Transcription initiation factor IIB

Size: 316 amino acids; 34833 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then

recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts

with HIV-1 Vpr. Interacts with GPBP1 (By similarity). Interacts with Epstein-Barr virus EBNA2

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1C9B (3D)

1DL6 (3D)

1RLY (3D)

1RO4 (3D)

1TFB (3D)

1VOL (3D)

2PHG (3D)

Secondary accessions: Q5JS30

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001505.1

ENSEMBL proteins:

ENSP00000378179 ENSP00000359531

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for GTF2B
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TFIIB)
	Human Recombinant Proteins from Abnova (GTF2B)

OriGene Purified Recombinant Human Protein: GTF2B

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	1939271 2449431 8946909
GO:0005667	transcription factor complex	IEA	--

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Antibodies for GTF2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GTF2B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TFIIB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GTF2B)
	Novus Biologicals Antibodies for GTF2B

Assays for GTF2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q00403

ProtoNet protein and cluster: Q00403

3 Blocks protein families:

IPB000812 Transcription factor TFIIB family

IPB006670 Cyclin

IPB013137 Zinc finger

UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403

Similarity: Belongs to the TFIIB family

Similarity: Contains 1 TFIIB-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GTF2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GTF2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001514

Applied Biosystems Silencer® siRNAs for GTF2B

Sigma-Aldrich siRNA for GTF2B

Sigma-Aldrich shRNA for GTF2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GTF2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001514
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001514
untagged cDNA clones in CMV expression vector (see all 2): NM_001514

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001514

UniProtKB/Swiss-Prot: TF2B_HUMAN, Q00403

Function: General factor that plays a major role in the activation of eukaryotic genes transcribed

by RNA polymerase II

Genatlas biochemistry entry for GTF2B:

general transcription factor IIB,35 kDa

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003743	translation initiation factor activity	IEA	--
GO:0005515	protein binding	IPI	8006019 15207693
GO:0008270	zinc ion binding	IEA	--
GO:0016251	general RNA polymerase II transcription factor activity	TAS	7671313
GO:0030528	transcription regulator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for GTF2B (Your Favorite Gene powered by Ingenuity)

VDR/RXR Activation
Estrogen Receptor Signaling
Glucocorticoid Receptor Signaling
CREB Signaling in Neurons
Androgen Signaling

GeneDecks GTF2B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GTF2B

5/134 Interacting proteins for GTF2B (Q00403^{1, 2} ENSP00000359531³) via UniProtKB, MINT, and/or STRING (see all 134 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELA	Q04206², ENSP00000311508³	MINT-62398 MINT-62399 STRING (score=.995)
EP300	Q09472², ENSP00000263253³	MINT-2584593 MINT-2584615 STRING (score=.981)
CREBBP	Q92793², ENSP00000371502³	MINT-6665325 STRING (score=.998)
GTF2F2	P13984², ENSP00000351886³	MINT-2982956 STRING (score=.998)
POU3F2	P20265¹	EBI-389564, EBI-1167176

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	EXP	8946909
GO:0006368	RNA elongation from RNA polymerase II promoter	EXP	9405375
GO:0006413	translational initiation	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GTF2B
8 Novoseek chemical compound relationships for GTF2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1,25 dihydroxy vitamin d3	44.39	1	9013769 (1)
zinc	41.64	24	18631123 (3), 7891725 (2), 9013769 (2), 14536083 (2) (see all 13)
phosphodiester	31.83	2	10872452 (1), 8631733 (1)
atp	0.00	1	8631733 (1)
estradiol	0.00	2	15079859 (1)
steroid	0.00	2	9379138 (1), 8990171 (1)
histidine	0.00	1	10819473 (1)
proline	0.00	1	9089417 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GTF2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GTF2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001514

Sigma-Aldrich siRNA for GTF2B

Sigma-Aldrich shRNA for GTF2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001514

REFSEQ mRNAs for GTF2B gene:

NM_001514.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001514

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001514
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001514
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001514

Additional cDNA sequence:

AB451296.1 AK289822.1 BC020597.1 CR590496.1 CR592227.1 CR598774.1 CR600115.1 CR619060.1

M76766.1 S44184.1

8 DOTS entries:

DT.217227 DT.92437115 DT.100651698 DT.95270437 DT.92437109 DT.92437111 DT.92437112 DT.100668090

24/246 AceView cDNA sequences (see all 246 ):

BI761841 AA031866 CR600115 NM_001514 AI803543 F02944 BX107185 BU182783

BC020597 AA195519 M76766 AI167866 CR619060 BP379342 CR590496 AA313473

H81749 BQ066911 BX488793 U47720 CB161485 AW303945 BM314476 BF438221

highest scoring ESTs for GTF2B:

M76766 AA360607 AA376394 AL532376 BC020597 BC021000 BE730096 BE894746 BE973858 BF028541

Unigene Cluster for GTF2B:

General transcription factor IIB

Hs.481852 [show with all ESTs]

Unigene Representative Sequence: NM_001514

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9
SP1:									-										-		-
SP2:									-
SP3:							-		-
SP4:									-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for GTF2B

2 Ensembl transcripts including schematic representations:

ENST00000394687 ENST00000370500

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GTF2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GTF2B

¹ / ² / ³

5 probe-sets matching GTF2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1070_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.95	M76766	1.00	1.00	1.00	1
37380_at²^{, 3}	U95-A	1	1.00	1.00	-0.14	0.45	X59268	0.80	1.00	0.91	1
37381_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.05	X59268	0.80	1.00	0.91	1
208066_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001514	0.60	1.00	0.82	1
208066_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks GTF2B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTACGCATTC

SOURCE GeneReport for Unigene cluster: Hs.481852
Expression variation in blood from EXPOLDB for GTF2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GTF2B gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GTF2B¹	--	general transcription factor IIB	95.57(n) 100(a)	479960 XM_537085.2 XP_537085.1
chimpanzee (Pan troglodytes)	GTF2B¹	--	general transcription factor IIB	99.26(n) 100(a)	743356 XM_001147170.1 XP_001147170.1
cow (Bos taurus)	GTF2B¹	--	general transcription factor IIB	93.78(n) 99.68(a)	513231 NM_001046142.1 NP_001039607.1
rat (Rattus norvegicus)	Gtf2b¹	--	general transcription factor IIB	89.98(n) 99.68(a)	81673 NM_031041.1 NP_112303.1
mouse (Mus musculus)	Gtf2b^{1, 5}	3⁵	general transcription factor IIB^{1, 5}	90.08(n)¹ 99.68(a)¹	229906¹ NM_145546.1¹ NP_663521.1¹ AI414792⁵ AI840450⁵ (see all 17)

About this table Species with no ortholog for GTF2B

ENSEMBL Gene Tree for GTF2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/253 NCBI SNPs in GTF2B are shown (see all 253 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 83)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4655888^1,2	A,C,F,H	89130774(+)	`tattgA/Taaacg`	1	--	ng3¹ tfbs³		4	EU EA WA	412
	rs4656067^1,2	A,C,F,H	89130802(+)	`caagaG/Ctcctt`	1	--	ng3¹		4	EU EA WA	416
	rs7536541^1,2	C,F,H	89129888(+)	`CAGTCG/ATAGCA`	1	--	ut5¹ ese³		4	EU EA WA	416
	rs12094090^1,2	F,H	89131810(+)	`AATCTT/ACTATT`	1	--	ng3¹		4	EU EA WA	420
	rs17130652^1,2	F,H	89130358(+)	`GCTAGC/GATGTT`	1	--	ng3¹		7	NA EU EA WA	560
	rs12096041^1,2	F,H	89130428(+)	`GCCTTG/CCATAC`	1	--	ng3¹		4	EU EA WA	418
	rs10922^1,2	C	89091374(-)	`TGGTAC/AGCATT`	1	--	ut3¹		1	MN	184
	rs2794318^1,2	A,C,F,H	89095570(+)	`GTCCAA/GTTCCA`	1	L/L	syn¹		8	EU EA WA NA	640
	rs7538427^1,2	A,C,F,H	89112010(+)	`gccatT/Cgggaa`	1	--	int¹		8	EU EA WA	836
	rs11807792^1,2	A,C,F,H	89098989(+)	`aaagaC/Tgctaa`	1	--	int¹		4	EU EA WA	412

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HapMap Linkage Disequilibrium images for GTF2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 189963

6 Novoseek disease relationships for GTF2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
herpes simplex	40.62	8	14764096 (1), 7791769 (1), 8972203 (1), 11371188 (1) (see all 7)
retinoblastoma	36.97	3	9433129 (1), 8628726 (1), 8434021 (1)
carcinoma embryonal	11.85	2	7878015 (1), 8887661 (1)
immunodeficiency	4.50	3	7707528 (1), 8800208 (1), 9292011 (1)
tumors	0.41	1	8628726 (1)
shock	0.00	5	16330756 (2), 17994014 (1), 11005381 (1), 15149597 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/318 PubMed articles for GTF2B gene (see all 318 ):

Cloning of a human gene encoding the general transcription initiation factor IIB. (PubMed id 1876184)^{1, 2, 3, 4} Ha I.... Reinberg D. (1991)
The HIV-1 Vpr co-activator induces a conformational change in TFIIB. (PubMed id 10359081)^{1, 3, 4} Agostini I.... Sire J. (1999)
Sequence of general transcription factor TFIIB and relationships to other initiation factors. (PubMed id 1946368)^{1, 3, 4} Malik S.... Roeder R.G. (1991)
Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. (PubMed id 11045620)^{1, 3, 4} Chen H.T.... Scott R.A. (2000)
Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. (PubMed id 7671313)^{1, 3, 4} Bagby S.... Ikura M. (1995)
The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. (PubMed id 8800208)^{1, 3, 4} Agostini I....Sire J. (1996)
Crystal structure of a TFIIB-TBP-TATA-element ternary complex. (PubMed id 7675079)^{1, 3, 4} Nikolov D.B.... Burley S.K. (1995)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. (PubMed id 8566795)^{3, 4} Umehara T....Horikoshi M. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2959	HGNC: 4648	AceView: GTF2B	Ensembl:ENSG00000137947	euGenes: HUgn2959
ECgene: GTF2B	H-InvDB: GTF2B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GTF2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GTF2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GTF2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GTF2B		Antibodies for GTF2B
	Explore super-pooled esiRNAs		Proteins for GTF2B
	Lentivirus-delivered shRNAs for GTF2B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GTF2B)
	Antibodies (GTF2B)
	Chimera RNAi (GTF2B)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (TFIIB)
	Antibodies (TFIIB)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for GTF2B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GTF2B

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GTF2B Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for GTF2B

Summaries
for GTF2B

Genomic Location
for GTF2B

Proteins
for GTF2B

Protein Domains/
Families
for GTF2B

Gene Function
for GTF2B

Pathways & Interactions
for GTF2B

Drugs & Compounds
for GTF2B

Transcripts
for GTF2B

Expression
for GTF2B

Orthologs
for GTF2B

Paralogs
for GTF2B

SNPs/Variants
for GTF2B

Disorders & Mutations
for GTF2B

Medical News
for GTF2B

Publications
for GTF2B

Search for GTF2B

Genome Databases showing GTF2B

Other Databases showing GTF2B

Specialized Databases showing GTF2B

Licensable Technologies
for GTF2B

Services
for GTF2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GTF2B Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor GTF2B

Summariesfor GTF2B

Genomic Locationfor GTF2B

Proteinsfor GTF2B

Protein Domains/Familiesfor GTF2B

Gene Functionfor GTF2B

Pathways & Interactionsfor GTF2B

Drugs & Compoundsfor GTF2B

Transcriptsfor GTF2B

Expression for GTF2B

Orthologsfor GTF2B

Paralogsfor GTF2B

SNPs/Variantsfor GTF2B

Disorders & Mutationsfor GTF2B

Medical Newsfor GTF2B

Publicationsfor GTF2B

Search for GTF2B

Genome Databases showing GTF2B

Other Databases showing GTF2B

Specialized Databases showing GTF2B

Licensable Technologiesfor GTF2B

Servicesfor GTF2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GTF2B

Summaries
for GTF2B

Genomic Location
for GTF2B

Proteins
for GTF2B

Protein Domains/
Families
for GTF2B

Gene Function
for GTF2B

Pathways & Interactions
for GTF2B

Drugs & Compounds
for GTF2B

Transcripts
for GTF2B

Expression
for GTF2B

Orthologs
for GTF2B

Paralogs
for GTF2B

SNPs/Variants
for GTF2B

Disorders & Mutations
for GTF2B

Medical News
for GTF2B

Publications
for GTF2B

Licensable Technologies
for GTF2B

Services
for GTF2B