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Aliases for GTF2B Gene

Aliases for GTF2B Gene

  • General Transcription Factor IIB 2 3 5
  • General Transcription Factor TFIIB 3 4
  • S300-II 3 4
  • TFIIB 3 4
  • TF2B 3 4
  • RNA Polymerase II Transcription Factor IIB 3
  • Transcription Initiation Factor IIB 3

External Ids for GTF2B Gene

Previous GeneCards Identifiers for GTF2B Gene

  • GC01M089795
  • GC01M088488
  • GC01M088655
  • GC01M088785
  • GC01M089030
  • GC01M089318
  • GC01M087435

Summaries for GTF2B Gene

Entrez Gene Summary for GTF2B Gene

  • This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF2B Gene

GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Diseases associated with GTF2B include Herpes Simplex and Familial Atrial Fibrillation. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. GO annotations related to this gene include transcription factor binding and thyroid hormone receptor binding.

UniProtKB/Swiss-Prot for GTF2B Gene

  • General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Gene Wiki entry for GTF2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2B Gene

Genomics for GTF2B Gene

Regulatory Elements for GTF2B Gene

Enhancers for GTF2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F089271 1.3 FANTOM5 ENCODE 14 -381.8 -381759 4.0 INSM2 KLF17 RAD21 YY1 ZNF335 GLIS2 ZNF366 SCRT2 ZNF416 ETV6 GBP1 GBP5 GBP4 GBP2 GTF2B GBP3 LRRC8C GC01P089283
GH01F089888 1.3 Ensembl ENCODE 11.3 -998.0 -998007 3.1 PKNOX1 FEZF1 ZNF2 GLIS2 GATA2 KLF7 FOS SP3 MEF2D ZNF292 GTF2B LOC100130455 LRRC8D GC01M089909 GC01P089867
GH01F088700 1.4 FANTOM5 Ensembl ENCODE 7.9 +190.6 190644 2.6 BCOR SOX13 ZNF146 ZMYM3 CEBPG TEAD3 SCRT2 SOX5 ZNF280D TEAD1 GBP3 GTF2B GBP2 GBP4 GBP1 GC01P088703 PKN2-AS1
GH01F089128 1.2 FANTOM5 ENCODE 8.8 -237.3 -237339 1.8 ARNT SIN3A ZBTB40 RAD21 YY1 CEBPB TBX21 MEF2D SMARCA4 CEBPA GBP1 GBP5 GBP4 GBP2 GBP7 GTF2B GBP3 PTGES3P1 LOC105378842
GH01F089309 1.3 FANTOM5 Ensembl ENCODE 7.8 -419.0 -418971 2.6 STAT1 MTA2 ZBTB2 HLF MAFG JUNB YY1 ZNF316 GATA2 ATF3 GBP1 GBP5 GBP4 GBP2 GTF2B PKN2 GBP3 LOC101927975 LRRC8C ENSG00000233235
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTF2B on UCSC Golden Path with GeneCards custom track

Promoters for GTF2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000540337 444 3000 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1

Genomic Location for GTF2B Gene

Chromosome:
1
Start:
88,852,638 bp from pter
End:
88,891,944 bp from pter
Size:
39,307 bases
Orientation:
Minus strand

Genomic View for GTF2B Gene

Genes around GTF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2B Gene

Proteins for GTF2B Gene

  • Protein details for GTF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00403-TF2B_HUMAN
    Recommended name:
    Transcription initiation factor IIB
    Protein Accession:
    Q00403
    Secondary Accessions:
    • A8K1A7
    • Q5JS30

    Protein attributes for GTF2B Gene

    Size:
    316 amino acids
    Molecular mass:
    34833 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 (By similarity). Interacts with Epstein-Barr virus EBNA2. Interacts with herpes simplex virus 1 protein ICP4.

    Three dimensional structures from OCA and Proteopedia for GTF2B Gene

neXtProt entry for GTF2B Gene

Post-translational modifications for GTF2B Gene

  • Ubiquitination at Lys 100 and Lys 178
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2B Gene

No data available for DME Specific Peptides for GTF2B Gene

Domains & Families for GTF2B Gene

Gene Families for GTF2B Gene

Suggested Antigen Peptide Sequences for GTF2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00403

UniProtKB/Swiss-Prot:

TF2B_HUMAN :
  • Belongs to the TFIIB family.
  • Contains 1 TFIIB-type zinc finger.
Family:
  • Belongs to the TFIIB family.
Similarity:
  • Contains 1 TFIIB-type zinc finger.
genes like me logo Genes that share domains with GTF2B: view

Function for GTF2B Gene

Molecular function for GTF2B Gene

GENATLAS Biochemistry:
general transcription factor IIB,35 kDa
UniProtKB/Swiss-Prot Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Gene Ontology (GO) - Molecular Function for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 8006019
GO:0008134 transcription factor binding IPI 9722567
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with GTF2B: view
genes like me logo Genes that share phenotypes with GTF2B: view

Animal Models for GTF2B Gene

MGI Knock Outs for GTF2B:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GTF2B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2B Gene

Localization for GTF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with GTF2B: view

Pathways & Interactions for GTF2B Gene

genes like me logo Genes that share pathways with GTF2B: view

Pathways by source for GTF2B Gene

Gene Ontology (GO) - Biological Process for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2B: view

No data available for SIGNOR curated interactions for GTF2B Gene

Drugs & Compounds for GTF2B Gene

(12) Drugs for GTF2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for GTF2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF2B: view

Transcripts for GTF2B Gene

Unigene Clusters for GTF2B Gene

General transcription factor IIB:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GTF2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for GTF2B Gene

GeneLoc Exon Structure for
GTF2B
ECgene alternative splicing isoforms for
GTF2B

Expression for GTF2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF2B Gene

Protein differential expression in normal tissues from HIPED for GTF2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1) and Lung (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF2B Gene



Protein tissue co-expression partners for GTF2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF2B Gene:

GTF2B

SOURCE GeneReport for Unigene cluster for GTF2B Gene:

Hs.481852
genes like me logo Genes that share expression patterns with GTF2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GTF2B Gene

Orthologs for GTF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2B 34 35
  • 99.37 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF2B 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2B 34 35
  • 95.68 (n)
cow
(Bos Taurus)
Mammalia GTF2B 34 35
  • 93.67 (n)
mouse
(Mus musculus)
Mammalia Gtf2b 34 16 35
  • 89.98 (n)
rat
(Rattus norvegicus)
Mammalia Gtf2b 34
  • 89.87 (n)
chicken
(Gallus gallus)
Aves GTF2B 34 35
  • 85.55 (n)
lizard
(Anolis carolinensis)
Reptilia GTF2B 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2b 34
  • 80.49 (n)
Str.18092 34
African clawed frog
(Xenopus laevis)
Amphibia gtf2b-A 34
zebrafish
(Danio rerio)
Actinopterygii gtf2b 34 35
  • 78.06 (n)
wufc44c11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.422 34
fruit fly
(Drosophila melanogaster)
Insecta TfIIB 36 34 35
  • 65.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009558 34
  • 64.33 (n)
worm
(Caenorhabditis elegans)
Secernentea ttb-1 36 34 35
  • 60.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13640g 34
  • 48.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUA7 34 35 37
  • 48.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR007C 34
  • 46.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TFIIB 34
  • 55.64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3214 34
rice
(Oryza sativa)
Liliopsida Os09g0534800 34
  • 53.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6926 35
  • 72 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC16E8.16 34
  • 51.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07289 34
  • 49.25 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2391 34
Species where no ortholog for GTF2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2B Gene

ENSEMBL:
Gene Tree for GTF2B (if available)
TreeFam:
Gene Tree for GTF2B (if available)

Paralogs for GTF2B Gene

No data available for Paralogs for GTF2B Gene

Variants for GTF2B Gene

Sequence variations from dbSNP and Humsavar for GTF2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs144944840 A colorectal cancer sample 88,860,150(+) TATTT(C/T)GAGGT nc-transcript-variant, reference, missense
rs10127863 -- 88,878,573(+) AAGAT(A/G)GCAAC intron-variant
rs10157783 -- 88,885,287(+) tacaa(A/C)aagtt intron-variant
rs10218485 -- 88,873,566(+) agtag(C/T)gactt intron-variant
rs10218561 -- 88,873,451(+) gcctc(A/G)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2B Gene

Variant ID Type Subtype PubMed ID
nsv830537 CNV gain 17160897
nsv830525 CNV loss 17160897
nsv830514 CNV loss 17160897
nsv546784 CNV loss 21841781
nsv462472 CNV loss 19166990
esv3586748 CNV loss 21293372
dgv360n54 CNV gain 21841781
dgv22n27 CNV gain 19166990

Variation tolerance for GTF2B Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2B Gene

Disorders for GTF2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GTF2B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search GTF2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for GTF2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2B
genes like me logo Genes that share disorders with GTF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF2B Gene

Publications for GTF2B Gene

  1. Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. (PMID: 11045620) Chen H.T. … Scott R.A. (Protein Sci. 2000) 3 4 22 64
  2. The HIV-1 Vpr co-activator induces a conformational change in TFIIB. (PMID: 10359081) Agostini I. … Sire J. (FEBS Lett. 1999) 3 4 22 64
  3. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. (PMID: 8800208) Agostini I. … Sire J. (J. Mol. Biol. 1996) 3 4 22 64
  4. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. (PMID: 7671313) Bagby S. … Ikura M. (Cell 1995) 3 4 22 64
  5. Cloning of a human gene encoding the general transcription initiation factor IIB. (PMID: 1876184) Ha I. … Reinberg D. (Nature 1991) 2 3 4 64

Products for GTF2B Gene

Sources for GTF2B Gene

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