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Aliases for GTF2A2 Gene

Aliases for GTF2A2 Gene

  • General Transcription Factor IIA Subunit 2 2 3 4
  • General Transcription Factor IIA 2 2 3 5
  • Transcription Initiation Factor IIA Gamma Chain 3 4
  • General Transcription Factor IIA, 2, 12kDa 2 3
  • TFIIA Gamma Subunit 2 3
  • TFIIA P12 Subunit 3 4
  • TFIIA-Gamma 3 4
  • TFIIA-12 3 4
  • TFIIAS 3 4
  • TF2A2 3 4
  • General Transcription Factor IIA, 2 (12kD Subunit) 2
  • HsT18745 3
  • T18745 3
  • TFIIA 3

External Ids for GTF2A2 Gene

Previous GeneCards Identifiers for GTF2A2 Gene

  • GC15M055489
  • GC15M052979
  • GC15M057510
  • GC15M057647
  • GC15M057718
  • GC15M059930
  • GC15M036752

Summaries for GTF2A2 Gene

Entrez Gene Summary for GTF2A2 Gene

  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GTF2A2 Gene

GTF2A2 (General Transcription Factor IIA Subunit 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot for GTF2A2 Gene

  • TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2A2 Gene

Genomics for GTF2A2 Gene

Regulatory Elements for GTF2A2 Gene

Enhancers for GTF2A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTF2A2 on UCSC Golden Path with GeneCards custom track

Promoters for GTF2A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTF2A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTF2A2 Gene

Chromosome:
15
Start:
59,638,062 bp from pter
End:
59,657,541 bp from pter
Size:
19,480 bases
Orientation:
Minus strand

Genomic View for GTF2A2 Gene

Genes around GTF2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A2 Gene

Proteins for GTF2A2 Gene

  • Protein details for GTF2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52657-T2AG_HUMAN
    Recommended name:
    Transcription initiation factor IIA subunit 2
    Protein Accession:
    P52657
    Secondary Accessions:
    • A8MYQ7
    • Q6FGB5

    Protein attributes for GTF2A2 Gene

    Size:
    109 amino acids
    Molecular mass:
    12457 Da
    Quaternary structure:
    • TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator (By similarity). TFIIA forms a complex with TBP. Interacts with SV40 Large T antigen.

    Three dimensional structures from OCA and Proteopedia for GTF2A2 Gene

neXtProt entry for GTF2A2 Gene

Proteomics data for GTF2A2 Gene at MOPED

Post-translational modifications for GTF2A2 Gene

  • Ubiquitination at Lys 101
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2A2 Gene

No data available for DME Specific Peptides for GTF2A2 Gene

Domains & Families for GTF2A2 Gene

Gene Families for GTF2A2 Gene

Suggested Antigen Peptide Sequences for GTF2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52657

UniProtKB/Swiss-Prot:

T2AG_HUMAN :
  • Belongs to the TFIIA subunit 2 family.
Family:
  • Belongs to the TFIIA subunit 2 family.
genes like me logo Genes that share domains with GTF2A2: view

Function for GTF2A2 Gene

Molecular function for GTF2A2 Gene

UniProtKB/Swiss-Prot Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Ontology (GO) - Molecular Function for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0008134 transcription factor binding IPI 8626665
GO:0042803 protein homodimerization activity IPI 8626665
genes like me logo Genes that share ontologies with GTF2A2: view
genes like me logo Genes that share phenotypes with GTF2A2: view

Animal Model Products

miRNA for GTF2A2 Gene

miRTarBase miRNAs that target GTF2A2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2A2 Gene

Localization for GTF2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2A2 Gene COMPARTMENTS Subcellular localization image for GTF2A2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for GTF2A2 Gene

Pathways & Interactions for GTF2A2 Gene

genes like me logo Genes that share pathways with GTF2A2: view

SIGNOR curated interactions for GTF2A2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter IEA,TAS --
GO:0016032 viral process IEA,TAS --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 7958899
genes like me logo Genes that share ontologies with GTF2A2: view

Drugs & Compounds for GTF2A2 Gene

No Compound Related Data Available

Transcripts for GTF2A2 Gene

mRNA/cDNA for GTF2A2 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GTF2A2 Gene

General transcription factor IIA, 2, 12kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for GTF2A2 Gene

GeneLoc Exon Structure for
GTF2A2
ECgene alternative splicing isoforms for
GTF2A2

Expression for GTF2A2 Gene

mRNA expression in normal human tissues for GTF2A2 Gene

Protein differential expression in normal tissues from HIPED for GTF2A2 Gene

This gene is overexpressed in Ovary (11.8), Oral epithelium (10.7), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2A2 Gene



SOURCE GeneReport for Unigene cluster for GTF2A2 Gene Hs.512934

genes like me logo Genes that share expression patterns with GTF2A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GTF2A2 Gene

Orthologs for GTF2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2A2 35
  • 95.11 (n)
  • 100 (a)
GTF2A2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2A2 35
  • 96.02 (n)
  • 99.08 (a)
GTF2A2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2a2 35
  • 95.11 (n)
  • 99.08 (a)
Gtf2a2 16
Gtf2a2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF2A2 35
  • 99.39 (n)
  • 100 (a)
GTF2A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2a2 35
  • 95.11 (n)
  • 99.08 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF2A2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2A2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2A2 35
  • 84.4 (n)
  • 96.33 (a)
GTF2A2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2A2 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a2 35
  • 80.73 (n)
  • 95.41 (a)
Str.7380 35
African clawed frog
(Xenopus laevis)
Amphibia TFIIAg 35
zebrafish
(Danio rerio)
Actinopterygii gtf2a2 35
  • 77.98 (n)
  • 93.58 (a)
gtf2a2 36
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1417 35
fruit fly
(Drosophila melanogaster)
Insecta TfIIA-S 37
  • 78 (a)
TfIIA-S 35
  • 66.34 (n)
  • 79.41 (a)
TfIIA-S 36
  • 76 (a)
OneToMany
TfIIA-S-2 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004370 35
  • 68.89 (n)
  • 76.19 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y111B2A.13 35
  • 53.59 (n)
  • 49.02 (a)
B0336.13 36
  • 32 (a)
OneToMany
Y111B2A.13 36
  • 44 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR071W 35
  • 46.8 (n)
  • 40.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12815g 35
  • 51.67 (n)
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOA2 35
  • 49.83 (n)
  • 42.57 (a)
TOA2 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24440 35
  • 54.88 (n)
  • 51.52 (a)
rice
(Oryza sativa)
Liliopsida Os.12011 35
Os05g0107700 35
  • 61.17 (n)
  • 54.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4078 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09748 35
  • 54.46 (n)
  • 49.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC553.11c 35
  • 52.88 (n)
  • 47.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
OneToOne
Species with no ortholog for GTF2A2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2A2 Gene

ENSEMBL:
Gene Tree for GTF2A2 (if available)
TreeFam:
Gene Tree for GTF2A2 (if available)

Paralogs for GTF2A2 Gene

Pseudogenes.org Pseudogenes for GTF2A2 Gene

genes like me logo Genes that share paralogs with GTF2A2: view

No data available for Paralogs for GTF2A2 Gene

Variants for GTF2A2 Gene

Sequence variations from dbSNP and Humsavar for GTF2A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4232 -- 59,638,932(+) AAAAA(A/G)AAGTT utr-variant-3-prime
rs5812981 -- 59,650,039(+) ACCAT(-/A)AATGT intron-variant
rs6494131 -- 59,653,141(+) GCAGT(C/G)GGGAG intron-variant
rs12050786 -- 59,654,724(+) TACac(A/T)tcact intron-variant
rs12148540 -- 59,638,188(+) caggt(A/G)tgagc utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GTF2A2 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv527307 CNV Gain 19592680
esv2668729 CNV Deletion 23128226

Variation tolerance for GTF2A2 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GTF2A2 Gene

Disorders for GTF2A2 Gene

Relevant External Links for GTF2A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2A2

No disorders were found for GTF2A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2A2 Gene

Publications for GTF2A2 Gene

  1. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. (PMID: 7958899) Ozer J. … Lieberman P.M. (Genes Dev. 1994) 2 3 4 67
  2. Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF). (PMID: 14570910) Nakadai T. … Tamura T.A. (J. Biol. Chem. 2004) 3 23
  3. Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II. (PMID: 11509574) Langelier M.F. … Coulombe B. (J. Biol. Chem. 2001) 3 23
  4. Potential targets for HSF1 within the preinitiation complex. (PMID: 11005381) Yuan C.X. … Gurley W.B. (Cell Stress Chaperones 2000) 3 23
  5. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. (PMID: 8626665) Ozer J. … Lieberman P.M. (J. Biol. Chem. 1996) 3 23

Products for GTF2A2 Gene

Sources for GTF2A2 Gene

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