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GTF2A2 Gene

protein-coding   GIFtS: 59
GCID: GC15M059930

General Transcription Factor IIA, 2, 12kDa

(Previous names: general transcription factor IIA, 2 (12kD subunit))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
General Transcription Factor IIA, 2, 12kDa1 2     TFIIAS2 3
TF2A22 3 5     TFIIA P12 Subunit2 3
General Transcription Factor IIA Subunit 22 3     General Transcription Factor IIA, 2 (12kD Subunit)1
Transcription Initiation Factor IIA Gamma Chain2 3     HsT187452
TFIIA-122 3     TFIIA2
TFIIA-gamma2 3     Transcription Initiation Factor IIA Subunit 22

External Ids:    HGNC: 46471   Entrez Gene: 29582   Ensembl: ENSG000001403077   OMIM: 6005195   UniProtKB: P526573   
ORGUL members:         

Export aliases for GTF2A2 gene to outside databases

Previous GC identifers: GC15M055489 GC15M052979 GC15M057510 GC15M057647 GC15M057718 GC15M036752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GTF2A2 Gene:
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA
polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM
313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves
recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a
factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits
(43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha
subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively,
and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 (PubMed 7724559)).(supplied by OMIM, Mar 2008)

GeneCards Summary for GTF2A2 Gene:
GTF2A2 (general transcription factor IIA, 2, 12kDa) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot: T2AG_HUMAN, P52657
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2A2 gene promoter:
         TBP   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   AP-4   CUTL1   POU3F2   AREB6   FOXJ2 (long isoform)   FOXJ2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGTF2A2 promoter sequence
   Search Chromatin IP Primers for GTF2A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

GTF2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M059930:  view genomic region     (about GC identifiers)

Start:
59,930,261 bp from pter      End:
59,949,740 bp from pter
Size:
19,480 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: T2AG_HUMAN, P52657 (See protein sequence)
Recommended Name: Transcription initiation factor IIA subunit 2  
Size: 109 amino acids; 12457 Da
Subunit: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally
believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6
general coactivator (By similarity). TFIIA forms a complex with TBP. Interacts with SV40 Large T antigen
1 PDB 3D structure from and Proteopedia for GTF2A2:
1NVP (3D)    
Secondary accessions: A8MYQ7 Q6FGB5

Explore the universe of human proteins at neXtProt for GTF2A2: NX_P52657

Explore proteomics data for GTF2A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys101
  • Modification sites at PhosphoSitePlus

  • See GTF2A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004483.1  
    ENSEMBL proteins: 
     ENSP00000379372   ENSP00000379376   ENSP00000379375   ENSP00000379373   ENSP00000418574  
     ENSP00000452648  
    Reactome Protein details: P52657

    GTF2A2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GTF: General transcription factors

    5 InterPro protein domains:
     IPR003194 TFIIA_gsu
     IPR009088 TFIIA_b-brl
     IPR015871 TFIIA_gsu_C
     IPR009083 TFIIA_a-hlx
     IPR015872 TFIIA_gsu_N

    Graphical View of Domain Structure for InterPro Entry P52657

    ProtoNet protein and cluster: P52657

    1 Blocks protein domain: IPB003194 Transcription initiation factor IIA

    UniProtKB/Swiss-Prot: T2AG_HUMAN, P52657
    Similarity: Belongs to the TFIIA subunit 2 family


    Find genes that share domains with GTF2A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2AG_HUMAN, P52657
    Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
    transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001103RNA polymerase II repressing transcription factor binding IEA--
    GO:0003713transcription coactivator activity IDA7958899
    GO:0005515protein binding IPI7724559
    GO:0008134transcription factor binding IPI8626665
    GO:0017025TBP-class protein binding IPI7724559
         
    Find genes that share ontologies with GTF2A2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GTF2A2:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GTF2A2

    miRNA
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    miRTarBase miRNAs that target GTF2A2:
    hsa-mir-26b-5p (MIRT029382)

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    Selected qRT-PCR Assays for microRNAs that regulate GTF2A2 (see all 16):
    hsa-miR-548v hsa-miR-128 hsa-miR-374a hsa-miR-3133 hsa-miR-186 hsa-miR-3662 hsa-miR-2116 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidGTF2A2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2AG_HUMAN, P52657: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005672transcription factor TFIIA complex IDA7724559
    GO:0005730NOT nucleolus IDA--
    GO:0030054cell junction IDA--

    Find genes that share ontologies with GTF2A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GTF2A2 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    Glucocorticoid Receptor Signaling0.43
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57


    Find genes that share SuperPaths with GTF2A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2A2 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Crosstalk Between CARM1 and ESRs

    1 GeneGo (Thomson Reuters) Pathway for GTF2A2
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    2 BioSystems Pathways for GTF2A2
        Eukaryotic Transcription Initiation
    Integrated Pancreatic Cancer Pathway

    Selected Reactome Pathways for GTF2A2 (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    2 Kegg Pathways  (Kegg details for GTF2A2):
        Basal transcription factors
    Viral carcinogenesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF2A2
    Interactions:

        GeneGlobe Interaction Network for GTF2A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2A2 (P526571, 3 ENSP000003793724) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202261, 3, ENSP000002303544EBI-1045262,EBI-355371 I2D: score=4 STRING: ENSP00000230354
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=7 STRING: ENSP00000384597
    GTF2A1P526553, ENSP000002981734I2D: score=4 STRING: ENSP00000298173
    TBPL1P623803, ENSP000002372644I2D: score=4 STRING: ENSP00000237264
    TAF4O002683, ENSP000002529964I2D: score=3 STRING: ENSP00000252996
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--

    Find genes that share ontologies with GTF2A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2A2 (T2AG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GTF2A2 gene: 
    NM_004492.2  

    Unigene Cluster for GTF2A2:

    General transcription factor IIA, 2, 12kDa
    Hs.512934  [show with all ESTs]
    Unigene Representative Sequence: NM_004492
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396060(uc002agg.3) ENST00000267869 ENST00000396064 ENST00000396063
    ENST00000396061 ENST00000484743 ENST00000559141 ENST00000559706 ENST00000480768
    ENST00000472508
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    hsa-miR-548v hsa-miR-128 hsa-miR-374a hsa-miR-3133 hsa-miR-186 hsa-miR-3662 hsa-miR-2116 hsa-miR-103a-2*
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    Additional mRNA sequence: 

    AK312015.1 BC000287.2 BC001919.1 BT007362.1 CR542192.1 U14193.1 U21242.1 X81713.1 

    13 DOTS entries:

    DT.99946205  DT.119268  DT.75101112  DT.100728396  DT.97843633  DT.40125418  DT.95097521  DT.95097495 
    DT.95097497  DT.95097512  DT.95097516  DT.95097518  DT.97769960 

    2 AceView cDNA sequences:

    AI126873 CD675580 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                      -                                       
    SP2:                    -                 -                                       
    SP3:                    -                 -                 -                     
    SP4:                                      -     -                                 
    SP5:                    -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for GTF2A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GTF2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAACCATA
    GTF2A2 Expression
    About this image

    GTF2A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512934
        Custom PCR Arrays for GTF2A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GTF2A2 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2a21 , 5 general transcription factor II A, 21, 5 95.11(n)1
    99.08(a)1
      9 (39.18 cM)5
    2354591  NM_001039519.21  NP_001034608.11 
     700125505 
    chicken
    (Gallus gallus)
    Aves GTF2A21 general transcription factor IIA, 2, 12kDa 84.4(n)
    96.33(a)
      770910  NM_001081708.1  NP_001075177.1 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2A26
    general transcription factor IIA, 2, 12kDa
    91(a)
    1 ↔ 1
    GL343428.1(280573-284063)
    African clawed frog
    (Xenopus laevis)
    Amphibia TFIIAg2 transcription factor IIA small subunit 81.11(n)    AY218796.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gtf2a21 general transcription factor IIA, 2 77.98(n)
    93.58(a)
      798997  NM_001020605.1  NP_001018441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIA-S1 , 3 transcription initiation from Pol II
    promoter general RNA polymerase II
    transcription factor less3
    Transcription-factor-IIA-S1
    78(a)3
    66.34(n)1
    79.41(a)1
      3 95C83
    428221  NM_079743.41  NP_524467.11 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y111B2A.131 CELE_Y111B2A.13 53.59(n)
    49.02(a)
      176682  NM_067243.4  NP_499644.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOA21 TOA2 49.83(n)
    42.57(a)
      853807   NP_012865.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G244401 AT4G24440 54.88(n)
    51.52(a)
      828546  NM_118577.4  NP_194175.1 
    rice
    (Oryza sativa)
    Liliopsida Os.120112 Oryza sativa (japonica cultivar-group) cDNA cloneJ013002D19, full insert sequence less 71.93(n)    AK065182.1 


    ENSEMBL Gene Tree for GTF2A2 (if available)
    TreeFam Gene Tree for GTF2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GTF2A2 gene

    Find genes that share paralogs with GTF2A2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for GTF2A2
    PGOHUM00000243956 PGOHUM00000249283 PGOHUM00000236356


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GTF2A2 (see all 573)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495202941,2
    --59929792(+) CTGTGC/TGCCTG 1 -- ds50010--------
    rs669138081,2
    C,F--59929846(+) TGTTAG/CCTGTA 1 -- ds50016Minor allele frequency- C:0.29NA WA EA 364
    rs1442831721,2
    --59929855(+) TAATAC/TAAAAT 1 -- ds50010--------
    rs125935801,2
    C,F,H--59929859(+) ACAAAA/GTAAAC 1 -- ds50011Minor allele frequency- G:0.07EA 120
    rs1836547541,2
    --59929930(+) CAAAAA/GGGTTT 1 -- ds50010--------
    rs1487508111,2
    --59929972(+) CTAGAG/TCTTTG 1 -- ds50010--------
    rs600287361,2
    --59930023(+) AGGTAC/TTTCAG 1 -- ds50010--------
    rs71717081,2
    C--59930030(+) TCAGGC/TTGACT 1 -- ds50010--------
    rs1401593071,2
    C--59930165(+) ACACCA/CTACAT 1 -- ds50010--------
    rs1442502111,2
    C--59930219(+) GTAGT-/GGAGGTTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GTF2A2 (59930261 - 59949740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GTF2A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668729CNV Deletion23128226
    nsv527307CNV Gain19592680
    nsv904254CNV Gain21882294
    nsv7266OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600519    OMIM disorders: --


    Find genes that share disorders with GTF2A2           About GenesLikeMe


    Export disorders for GTF2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GTF2A2 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with GTF2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. (PubMed id 7958899)1, 2, 3 Ozer J.... Lieberman P.M. (Genes Dev. 1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)1, 2 Lee S.-K.... Lee J.W. (J. Biol. Chem. 1999)
    4. Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. (PubMed id 7724559)1, 2 Dejong J.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    5. Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. (PubMed id 7958900)1, 2 Sun X.... Reinberg D. (Genes Dev. 1994)
    6. Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF). (PubMed id 14570910)1, 9 Nakadai T....Tamura T.A. (J. Biol. Chem. 2004)
    7. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. (PubMed id 8626665)1, 9 Ozer J....Lieberman P.M. (J. Biol. Chem. 1996)
    8. Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II. (PubMed id 11509574)1, 9 Langelier M.F....Coulombe B. (J. Biol. Chem. 2001)
    9. Potential targets for HSF1 within the preinitiation complex. (PubMed id 11005381)1, 9 Yuan C.X. and Gurley W.B. (amp 2000)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2958 HGNC: 4647 AceView: GTF2A2 Ensembl:ENSG00000140307 euGenes: HUgn2958
    ECgene: GTF2A2 Kegg: 2958 H-InvDB: GTF2A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GTF2A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GTF2A2 gene:
    Search GeneIP for patents involving GTF2A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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