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Aliases for GTF2A2 Gene

Aliases for GTF2A2 Gene

  • General Transcription Factor IIA Subunit 2 2 3 4 5
  • Transcription Initiation Factor IIA Gamma Chain 3 4
  • General Transcription Factor IIA, 2, 12kDa 2 3
  • General Transcription Factor IIA 2 2 3
  • TFIIA Gamma Subunit 2 3
  • TFIIA P12 Subunit 3 4
  • TFIIA-Gamma 3 4
  • TFIIA-12 3 4
  • TFIIAS 3 4
  • TF2A2 3 4
  • General Transcription Factor IIA, 2 (12kD Subunit) 2
  • Transcription Initiation Factor IIA Subunit 2 3
  • HsT18745 3
  • T18745 3
  • TFIIA 3

External Ids for GTF2A2 Gene

Previous GeneCards Identifiers for GTF2A2 Gene

  • GC15M055489
  • GC15M052979
  • GC15M057510
  • GC15M057647
  • GC15M057718
  • GC15M059930
  • GC15M036752

Summaries for GTF2A2 Gene

Entrez Gene Summary for GTF2A2 Gene

  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GTF2A2 Gene

GTF2A2 (General Transcription Factor IIA Subunit 2) is a Protein Coding gene. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot for GTF2A2 Gene

  • TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2A2 Gene

Genomics for GTF2A2 Gene

Regulatory Elements for GTF2A2 Gene

Enhancers for GTF2A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GTF2A2 on UCSC Golden Path with GeneCards custom track

Promoters for GTF2A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GTF2A2 Gene

Chromosome:
15
Start:
59,638,062 bp from pter
End:
59,657,541 bp from pter
Size:
19,480 bases
Orientation:
Minus strand

Genomic View for GTF2A2 Gene

Genes around GTF2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A2 Gene

Proteins for GTF2A2 Gene

  • Protein details for GTF2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52657-T2AG_HUMAN
    Recommended name:
    Transcription initiation factor IIA subunit 2
    Protein Accession:
    P52657
    Secondary Accessions:
    • A8MYQ7
    • Q6FGB5

    Protein attributes for GTF2A2 Gene

    Size:
    109 amino acids
    Molecular mass:
    12457 Da
    Quaternary structure:
    • TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator (By similarity). TFIIA forms a complex with TBP. Interacts with SV40 Large T antigen.

    Three dimensional structures from OCA and Proteopedia for GTF2A2 Gene

neXtProt entry for GTF2A2 Gene

Post-translational modifications for GTF2A2 Gene

  • Ubiquitination at Lys 101
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2A2 Gene

No data available for DME Specific Peptides for GTF2A2 Gene

Domains & Families for GTF2A2 Gene

Gene Families for GTF2A2 Gene

Suggested Antigen Peptide Sequences for GTF2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52657

UniProtKB/Swiss-Prot:

T2AG_HUMAN :
  • Belongs to the TFIIA subunit 2 family.
Family:
  • Belongs to the TFIIA subunit 2 family.
genes like me logo Genes that share domains with GTF2A2: view

Function for GTF2A2 Gene

Molecular function for GTF2A2 Gene

UniProtKB/Swiss-Prot Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Ontology (GO) - Molecular Function for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0003713 transcription coactivator activity IDA 7958899
GO:0005515 protein binding IPI 7724559
GO:0008134 transcription factor binding IPI 8626665
GO:0017025 TBP-class protein binding IPI 7724559
genes like me logo Genes that share ontologies with GTF2A2: view
genes like me logo Genes that share phenotypes with GTF2A2: view

Animal Model Products

CRISPR Products

miRNA for GTF2A2 Gene

miRTarBase miRNAs that target GTF2A2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2A2 Gene

Localization for GTF2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTF2A2 Gene COMPARTMENTS Subcellular localization image for GTF2A2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005672 transcription factor TFIIA complex IDA 7724559
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GTF2A2: view

Pathways & Interactions for GTF2A2 Gene

genes like me logo Genes that share pathways with GTF2A2: view

SIGNOR curated interactions for GTF2A2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0016032 viral process IEA --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2A2: view

Drugs & Compounds for GTF2A2 Gene

No Compound Related Data Available

Transcripts for GTF2A2 Gene

mRNA/cDNA for GTF2A2 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GTF2A2 Gene

General transcription factor IIA, 2, 12kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for GTF2A2 Gene

GeneLoc Exon Structure for
GTF2A2
ECgene alternative splicing isoforms for
GTF2A2

Expression for GTF2A2 Gene

mRNA expression in normal human tissues for GTF2A2 Gene

Protein differential expression in normal tissues from HIPED for GTF2A2 Gene

This gene is overexpressed in Ovary (11.8), Oral epithelium (10.7), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF2A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of GTF2A2 Gene:

GTF2A2

SOURCE GeneReport for Unigene cluster for GTF2A2 Gene:

Hs.512934
genes like me logo Genes that share expression patterns with GTF2A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GTF2A2 Gene

Orthologs for GTF2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTF2A2 34
  • 95.11 (n)
  • 100 (a)
GTF2A2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2A2 34
  • 96.02 (n)
  • 99.08 (a)
GTF2A2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2a2 34
  • 95.11 (n)
  • 99.08 (a)
Gtf2a2 16
Gtf2a2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTF2A2 34
  • 99.39 (n)
  • 100 (a)
GTF2A2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2a2 34
  • 95.11 (n)
  • 99.08 (a)
oppossum
(Monodelphis domestica)
Mammalia GTF2A2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2A2 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2A2 34
  • 84.4 (n)
  • 96.33 (a)
GTF2A2 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2A2 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a2 34
  • 80.73 (n)
  • 95.41 (a)
Str.7380 34
African clawed frog
(Xenopus laevis)
Amphibia TFIIAg 34
zebrafish
(Danio rerio)
Actinopterygii gtf2a2 34
  • 77.98 (n)
  • 93.58 (a)
gtf2a2 35
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1417 34
fruit fly
(Drosophila melanogaster)
Insecta TfIIA-S 36
  • 78 (a)
TfIIA-S 34
  • 66.34 (n)
  • 79.41 (a)
TfIIA-S 35
  • 76 (a)
OneToMany
TfIIA-S-2 35
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004370 34
  • 68.89 (n)
  • 76.19 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y111B2A.13 34
  • 53.59 (n)
  • 49.02 (a)
B0336.13 35
  • 32 (a)
OneToMany
Y111B2A.13 35
  • 44 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR071W 34
  • 46.8 (n)
  • 40.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12815g 34
  • 51.67 (n)
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOA2 34
  • 49.83 (n)
  • 42.57 (a)
TOA2 35
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24440 34
  • 54.88 (n)
  • 51.52 (a)
rice
(Oryza sativa)
Liliopsida Os.12011 34
Os05g0107700 34
  • 61.17 (n)
  • 54.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4078 34
bread mold
(Neurospora crassa)
Ascomycetes NCU09748 34
  • 54.46 (n)
  • 49.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC553.11c 34
  • 52.88 (n)
  • 47.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 74 (a)
OneToOne
Species where no ortholog for GTF2A2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2A2 Gene

ENSEMBL:
Gene Tree for GTF2A2 (if available)
TreeFam:
Gene Tree for GTF2A2 (if available)

Paralogs for GTF2A2 Gene

Pseudogenes.org Pseudogenes for GTF2A2 Gene

genes like me logo Genes that share paralogs with GTF2A2: view

No data available for Paralogs for GTF2A2 Gene

Variants for GTF2A2 Gene

Sequence variations from dbSNP and Humsavar for GTF2A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3053076 -- 59,638,441(+) TGTAC(-/ATG)ATAAA downstream-variant-500B, cds-indel
rs3736104 -- 59,642,467(-) AGTCT(C/G)CCAAC intron-variant
rs4270113 -- 59,658,277(+) TTTGG(A/G)AGAAG upstream-variant-2KB
rs4274384 -- 59,641,152(+) AGTTT(A/G)AGACC intron-variant
rs4232 -- 59,638,932(+) AAAAA(A/G)AAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GTF2A2 Gene

Variant ID Type Subtype PubMed ID
esv2668729 CNV deletion 23128226
esv3569653 CNV gain 25503493
esv3636644 CNV loss 21293372
esv3636646 CNV gain 21293372
esv3636647 CNV gain 21293372
nsv1043693 CNV loss 25217958
nsv1122972 CNV deletion 24896259
nsv527307 CNV gain 19592680
nsv569605 CNV loss 21841781
nsv7266 OTHER inversion 18451855

Variation tolerance for GTF2A2 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF2A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2A2 Gene

Disorders for GTF2A2 Gene

Relevant External Links for GTF2A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF2A2

No disorders were found for GTF2A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2A2 Gene

Publications for GTF2A2 Gene

  1. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. (PMID: 7958899) Ozer J. … Lieberman P.M. (Genes Dev. 1994) 2 3 4 65
  2. Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF). (PMID: 14570910) Nakadai T. … Tamura T.A. (J. Biol. Chem. 2004) 3 22 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II. (PMID: 11509574) Langelier M.F. … Coulombe B. (J. Biol. Chem. 2001) 3 22 65
  5. Potential targets for HSF1 within the preinitiation complex. (PMID: 11005381) Yuan C.X. … Gurley W.B. (Cell Stress Chaperones 2000) 3 22 65

Products for GTF2A2 Gene

Sources for GTF2A2 Gene

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