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Aliases for GTF2A1L Gene

Aliases for GTF2A1L Gene

  • General Transcription Factor IIA, 1-Like 2 3
  • ALF 3 4 6
  • General Transcription Factor II A, 1-Like Factor 3 4
  • TFIIA-Alpha And Beta-Like Factor 3
  • TFIIA Large Subunit Isoform ALF 3
  • TFIIA Alpha/Beta Like Factor 2
  • TFIIA-Alpha/Beta-Like Factor 3
  • GTF2A1-Like Factor 3
  • GTF2A1LF 4

External Ids for GTF2A1L Gene

Previous GeneCards Identifiers for GTF2A1L Gene

  • GC02P048651
  • GC02P048698
  • GC02P048844

Summaries for GTF2A1L Gene

Entrez Gene Summary for GTF2A1L Gene

  • The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]

GeneCards Summary for GTF2A1L Gene

GTF2A1L (General Transcription Factor IIA, 1-Like) is a Protein Coding gene. Among its related pathways are Viral carcinogenesis and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is STON2.

UniProtKB/Swiss-Prot for GTF2A1L Gene

  • May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.

Gene Wiki entry for GTF2A1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2A1L Gene

Genomics for GTF2A1L Gene

Regulatory Elements for GTF2A1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GTF2A1L Gene

48,617,798 bp from pter
48,733,148 bp from pter
115,351 bases
Plus strand

Genomic View for GTF2A1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A1L Gene

Proteins for GTF2A1L Gene

  • Protein details for GTF2A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TFIIA-alpha and beta-like factor
    Protein Accession:
    Secondary Accessions:
    • B4DY14
    • Q53FD9
    • Q5D050

    Protein attributes for GTF2A1L Gene

    478 amino acids
    Molecular mass:
    52444 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD39617.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The in vivo relevance of this transcript of the STON1 (AC Q9Y6Q2) and GTF2A1L genes creating a chimeric protein of 1182 residues is uncertain.; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF2A1L Gene


neXtProt entry for GTF2A1L Gene

Proteomics data for GTF2A1L Gene at MOPED

Post-translational modifications for GTF2A1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2A1L Gene

Antibody Products

No data available for DME Specific Peptides for GTF2A1L Gene

Domains for GTF2A1L Gene

Protein Domains for GTF2A1L Gene

Suggested Antigen Peptide Sequences for GTF2A1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UNN4
  • Belongs to the TFIIA subunit 1 family.
genes like me logo Genes that share domains with GTF2A1L: view

No data available for Gene Families for GTF2A1L Gene

Function for GTF2A1L Gene

Molecular function for GTF2A1L Gene

UniProtKB/Swiss-Prot Function: May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
UniProtKB/Swiss-Prot Induction: Down-regulated in Sertoli cell-only syndrome (SCOS) patients.

Gene Ontology (GO) - Molecular Function for GTF2A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 10364255
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GTF2A1L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTF2A1L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GTF2A1L Gene

Localization for GTF2A1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A1L Gene

Nucleus. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.

Subcellular locations from

Jensen Localization Image for GTF2A1L Gene COMPARTMENTS Subcellular localization image for GTF2A1L gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for GTF2A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005672 transcription factor TFIIA complex IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GTF2A1L: view

Pathways for GTF2A1L Gene

genes like me logo Genes that share pathways with GTF2A1L: view

Pathways by source for GTF2A1L Gene

2 KEGG pathways for GTF2A1L Gene

Gene Ontology (GO) - Biological Process for GTF2A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10364255
GO:0006367 transcription initiation from RNA polymerase II promoter IEA --
GO:0050890 cognition IMP 23227193
genes like me logo Genes that share ontologies with GTF2A1L: view

Transcripts for GTF2A1L Gene

Unigene Clusters for GTF2A1L Gene

General transcription factor IIA, 1-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTF2A1L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GTF2A1L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A1L Gene

No ASD Table

Relevant External Links for GTF2A1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTF2A1L Gene

mRNA expression in normal human tissues for GTF2A1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GTF2A1L Gene

This gene is overexpressed in Colon - Sigmoid (6.9), Testis (6.0), Esophagus - Muscularis (5.3), and Esophagus - Gastroesophageal Junction (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GTF2A1L Gene

SOURCE GeneReport for Unigene cluster for GTF2A1L Gene Hs.732016

mRNA Expression by UniProt/SwissProt for GTF2A1L Gene

Tissue specificity: Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis.
genes like me logo Genes that share expressions with GTF2A1L: view

In Situ Assay Products

Orthologs for GTF2A1L Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2A1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTF2A1L 35
  • 99.72 (n)
  • 99.58 (a)
  • 100 (a)
(Bos Taurus)
Mammalia GTF2A1L 36
  • 53 (a)
(Canis familiaris)
Mammalia GTF2A1L 35
  • 89.85 (n)
  • 84.66 (a)
(Mus musculus)
Mammalia Gtf2a1l 35
  • 76.42 (n)
  • 72.86 (a)
Gtf2a1l 16
Gtf2a1l 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia GTF2A1L 36
  • 32 (a)
(Rattus norvegicus)
Mammalia Gtf2a1l 35
  • 77.85 (n)
  • 74.79 (a)
(Gallus gallus)
Aves GTF2A1L 35
  • 65.4 (n)
  • 51.59 (a)
GTF2A1L 36
  • 40 (a)
(Anolis carolinensis)
Reptilia GTF2A1L 36
  • 43 (a)
African clawed frog
(Xenopus laevis)
Amphibia ALF 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a1l 35
  • 60.22 (n)
  • 54.38 (a)
Str.19885 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14067 35
(Danio rerio)
Actinopterygii gtf2a1l 35
  • 54.52 (n)
  • 53.11 (a)
(Caenorhabditis elegans)
Secernentea pqn-51 36
  • 18 (a)
Species with no ortholog for GTF2A1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2A1L Gene

Gene Tree for GTF2A1L (if available)
Gene Tree for GTF2A1L (if available)

Paralogs for GTF2A1L Gene

Paralogs for GTF2A1L Gene

Selected SIMAP similar genes for GTF2A1L Gene using alignment to 5 proteins: Pseudogenes for GTF2A1L Gene

genes like me logo Genes that share paralogs with GTF2A1L: view

Variants for GTF2A1L Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF2A1L Gene

Variant ID Type Subtype PubMed ID
nsv833981 CNV Loss 17160897
nsv833992 CNV Gain 17160897
nsv874004 CNV Loss 21882294
nsv2719 CNV Loss 18451855
esv991713 CNV Deletion 20482838
esv2720035 CNV Deletion 23290073
esv2676191 CNV Deletion 23128226
esv997251 CNV Loss 20482838
esv24510 CNV Loss 19812545

Relevant External Links for GTF2A1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GTF2A1L Gene

Disorders for GTF2A1L Gene

(1) University of Copenhagen DISEASES for GTF2A1L Gene

Relevant External Links for GTF2A1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GTF2A1L: view

No data available for UniProtKB/Swiss-Prot for GTF2A1L Gene

Publications for GTF2A1L Gene

  1. Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation. (PMID: 11889132) Xie W. … DeJong J. (J. Biol. Chem. 2002) 2 3 23
  2. Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis. (PMID: 10364255) Upadhyaya A.B. … DeJong J. (J. Biol. Chem. 1999) 2 3 4
  3. Involvement of ALF in human spermatogenesis and male infertility. (PMID: 16525715) Huang M. … Sha J. (Int. J. Mol. Med. 2006) 2 3 4
  4. TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse. (PMID: 11159353) Han S. … DeJong J. (Biol. Reprod. 2001) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GTF2A1L Gene

Sources for GTF2A1L Gene

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