Aliases for GTF2A1L Gene
External Ids for GTF2A1L Gene
Previous GeneCards Identifiers for GTF2A1L Gene
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]
GeneCards Summary for GTF2A1L Gene
GTF2A1L (General Transcription Factor IIA Subunit 1 Like) is a Protein Coding gene. Diseases associated with GTF2A1L include male infertility. Among its related pathways are Viral carcinogenesis and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is STON2.
UniProtKB/Swiss-Prot for GTF2A1L Gene
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.