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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GTF2A1 Gene

protein-coding   GIFtS: 60
GCID: GC14M081646

General Transcription Factor IIA, 1, 19/37kDa

(Previous names: glucose regulated protein, 58kD pseudogene)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
General Transcription Factor IIA, 1, 19/37kDa1 2     TFIIA-422 3
Glucose Regulated Protein, 58kD Pseudogene1 2     TFIIAL2 3
General Transcription Factor IIA Subunit 12 3     TFIIA2
Transcription Initiation Factor TFIIA 42 KDa Subunit2 3     TFIIA Alpha, P552
TF2A12 3     Transcription Initiation Factor IIA Subunit 12

External Ids:    HGNC: 46461   Entrez Gene: 29572   Ensembl: ENSG000001654177   OMIM: 6005205   UniProtKB: P526553   

Export aliases for GTF2A1 gene to outside databases

Previous GC identifers: GC14M079152 GC14M075463 GC14M079634 GC14M079636 GC14M080716 GC14M061813


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GTF2A1 Gene:
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA
polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993
(PubMed 8224848)). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-,
and 12-kD subunits.(supplied by OMIM, Jul 2010)

GeneCards Summary for GTF2A1 Gene: 
GTF2A1 (general transcription factor IIA, 1, 19/37kDa) is a protein-coding gene. Diseases associated with GTF2A1 include sporadic breast cancer, and herpes simplex, and among its related super-pathways are Assembly of RNA Polymerase-II Initiation Complex and RNA Polymerase II Pre-transcription Events. GO annotations related to this gene include transcription coactivator activity and protein heterodimerization activity. An important paralog of this gene is STON2.

UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

Gene Wiki entry for GTF2A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTF2A1 gene promoter:
         MyoD   FOXJ2   POU6F1 (c2)   ZID   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GTF2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GTF2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q31

GTF2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2A1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M081646:  view genomic region     (about GC identifiers)

Start:
81,641,796 bp from pter      End:
81,687,721 bp from pter
Size:
45,926 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655 (See protein sequence)
Recommended Name: Transcription initiation factor IIA subunit 1  
Size: 376 amino acids; 41514 Da
Subunit: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally
believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex
with TBP
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for GTF2A1:
1NVP (3D)    
Secondary accessions: Q3KNQ9
Alternative initiation: 2 isoforms:  P52655-1   P52655-2   

Explore the universe of human proteins at neXtProt for GTF2A1: NX_P52655

Explore proteomics data for GTF2A1 at MOPED 

Post-translational modifications:

  • UniProtKB: The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage
    promotes proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52655

  • GTF2A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GTF2A1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265869.1  NP_056943.1  NP_963889.1  

    ENSEMBL proteins: 
     ENSP00000452454   ENSP00000298173   ENSP00000409492  
    Reactome Protein details: P52655
    Human Recombinant Protein Products for GTF2A1: 
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    Cloud-Clone Corp. Proteins for GTF2A1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005672transcription factor TFIIA complex IDA7724559

    GTF2A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GTF: General transcription factors

    4 InterPro protein domains:
     IPR009088 TFIIA_b-brl
     IPR009083 TFIIA_a-hlx
     IPR004855 TFIIA_asu/bsu
     IPR013028 TFIIA_asu_N

    Graphical View of Domain Structure for InterPro Entry P52655

    ProtoNet protein and cluster: P52655

    1 Blocks protein domain: IPB004855 Transcription factor IIA

    UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655
    Similarity: Belongs to the TFIIA subunit 1 family


    GTF2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF2AA_HUMAN, P52655
    Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
    transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA7724559
    GO:0003713transcription coactivator activity TAS8224850
    GO:0005515protein binding IPI8006019
    GO:0008134transcription factor binding IPI8626665
    GO:0017025TBP-class protein binding IPI7724559
         
    GTF2A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gtf2a1):
     no phenotypic analysis 

    GTF2A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GTF2A1 
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    SwitchGear 3'UTR luciferase reporter plasmidGTF2A1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GTF2A1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.70
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    HIV Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription Initiation0.67
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    Glucocorticoid Receptor Signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GTF2A1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF2A1 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Crosstalk Between CARM1 and ESRs

    1 GeneGo (Thomson Reuters) Pathway for GTF2A1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    5/15        Reactome Pathways for GTF2A1 (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    2         Kegg Pathways  (Kegg details for GTF2A1):
        Basal transcription factors
    Viral carcinogenesis


    GTF2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for GTF2A1 (P526553 ENSP000002981734) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    GTF2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTF2A1 (TF2AA)

    Search CenterWatch for drugs/clinical trials and news about GTF2A1 / TF2AA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GTF2A1 gene (3 alternative transcripts): 
    NM_001278940.1  NM_015859.3  NM_201595.2  

    Unigene Cluster for GTF2A1:

    General transcription factor IIA, 1, 19/37kDa
    Hs.592334  [show with all ESTs]
    Unigene Representative Sequence: NR_048573
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553612(uc001xvf.1 uc010atb.1 uc001xvg.1) ENST00000298173
    ENST00000434192 ENST00000556268
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GTF2A1:
    hsa-miR-142-3p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK021641.1 AK025178.1 BC037828.1 BC041410.2 BC050703.1 BC107155.2 BC107156.1 D14886.1 
    D14887.1 NR_048573.1 X75383.1 X77225.1 

    9 DOTS entries:

    DT.454877  DT.408700  DT.100719932  DT.91980156  DT.92415311  DT.100699780  DT.100815776  DT.421315 
    DT.95184899 

    24/159 AceView cDNA sequences (see all 159):

    AI279371 NM_201595 AA811331 BU633617 D14886 BM721365 BF593481 BQ006826 
    X75383 X77225 BU181924 AA811332 AA234995 BX500812 W31188 BX493028 
    AK021641 BM479124 AI952296 BM750235 BQ215993 AA490430 AW192220 NM_015859 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GTF2A1 expression in normal human tissues (normalized intensities)      GTF2A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATTTTAA
    GTF2A1 Expression
    About this image


    GTF2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See GTF2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GTF2A1

    SOURCE GeneReport for Unigene cluster: Hs.592334
        SABiosciences Custom PCR Arrays for GTF2A1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GTF2A1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2a11 , 5 general transcription factor II A, 11, 5 90.69(n)1
    97.07(a)1
      12 (45.02 cM)5
    836021  NM_031391.21  NP_113568.21 
     915559165 
    chicken
    (Gallus gallus)
    Aves GTF2A11 general transcription factor IIA, 1, 19/37kDa 84.57(n)
    90.69(a)
      423389  NM_001031207.2  NP_001026378.2 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2A16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    1(17893254-17904674)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292482 Xenopus laevis transcription factor IIA large subunit-2 more 81.25(n)    AY218795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.246692 Danio rerio mRNA similar to general transcription factor more 75.77(n)    BC048894.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIA-L1 Transcription factor IIA L 47.08(n)
    38.87(a)
      43284  NM_057647.3  NP_476995.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pqn-511 Protein PQN-51 46.13(n)
    33.93(a)
      178893  NM_071954.4  NP_504355.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOA16
    TFIIA large subunit; involved in transcriptional a...
    16(a)
    1 → many
    XV(711683-712543)


    ENSEMBL Gene Tree for GTF2A1 (if available)
    TreeFam Gene Tree for GTF2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GTF2A1 gene
    STON22  GTF2A1L2  STON12  STON1-GTF2A1L2  

    GTF2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/818 SNPs in GTF2A1 are shown (see all 818)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356674
    A breast cancer sample4--see VAR_0356672 L V mis40--------
    VAR_0540434
    ----see VAR_0540432 A P mis40--------
    rs1908134751,2
    C--62676872(+) TTCCAA/GTATAT 2 -- us2k10--------
    rs1920115011,2
    --81641369(+) TTTGGC/TGGGGG 3 -- ds50010--------
    rs1432048361,2
    --81641370(+) TTGGCA/GGGGGG 3 -- ds50010--------
    rs733422731,2
    C,F--81641372(+) GGCGGG/AGGGAG 3 -- ds50012Minor allele frequency- A:0.05WA 120
    rs746384151,2
    C--81641425(+) CCCATA/TCCCAG 3 -- ds50010--------
    rs80124661,2
    C,F,H--81641464(+) CTGCTG/ATAGCC 3 -- ds500117Minor allele frequency- A:0.12NS EA NA WA CSA 2054
    rs1482712321,2
    --81641717(+) TGTCAC/TTTTAC 3 -- ds50010--------
    rs71503891,2
    H--81641919(+) TTCAGC/ATGAAT 3 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for GTF2A1 (81641796 - 81687721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GTF2A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902118CNV Loss21882294
    nsv902117CNV Loss21882294
    nsv832841CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600520    OMIM disorders: --

    6 diseases for GTF2A1:    About MalaCards
    sporadic breast cancer    herpes simplex    celiac disease    gastric cancer
    ovarian cancer    breast cancer


    GTF2A1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GTF2A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 9.67 1 15081896 (1)
    immunodeficiency 0 1 8151790 (1)

    Genetic Association Database (GAD): GTF2A1
    Human Genome Epidemiology (HuGE) Navigator: GTF2A1 (2 documents)

    Export disorders for GTF2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GTF2A1 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with GTF2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. (PubMed id 8224848)1, 2, 3, 9 Dejong J. and Roeder R.G. (1993)
    2. Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PubMed id 11278496)1, 2, 9 Solow S.... Lieberman P.M. (2001)
    3. Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. (PubMed id 15257296)1, 2, 9 Hoiby T....Stunnenberg H.G. (2004)
    4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    5. Interaction of polymorphisms in the interleukin 1B-31 and general transcription factor 2A1 genes on the susceptibility to gastric cancer. (PubMed id 17596959)1, 4 Lee K.A....Kim J.W. (2007)
    6. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. (PubMed id 16537915)1, 2 Zhou H.... Stunnenberg H.G. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    10. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. (PubMed id 8224850)1, 2 Ma D.... Handa H. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2957 HGNC: 4646 AceView: GTF2A1 Ensembl:ENSG00000165417 euGenes: HUgn2957
    ECgene: GTF2A1 Kegg: 2957 H-InvDB: GTF2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GTF2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GTF2A1 gene:
    Search GeneIP for patents involving GTF2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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