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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GTF2A1 Gene

protein-coding   GIFtS: 55
GCID: GC14M081646

general transcription factor IIA, 1, 19/37kDa

(Previous names: glucose regulated protein, 58kD pseudogene )
 Explore 7 diseases affiliated with
GTF2A1 via our new
 Human Malady Compendium 
Biological research products
for GTF2A1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
General Transcription Factor IIA, 1, 19/37kDa1 2     TF2A12 3
TFIIA1 2     TFIIA-422 3
Glucose Regulated Protein, 58kD Pseudogene1 2     TFIIAL2 3
General Transcription Factor IIA Subunit 12 3     TFIIA Alpha, P552
Transcription Initiation Factor TFIIA 42 KDa Subunit2 3     Transcription Initiation Factor IIA Subunit 12

External Ids:    HGNC: 46461   Entrez Gene: 29572   Ensembl: ENSG000001654177   OMIM: 6005205   UniProtKB: P526553   

Export aliases for GTF2A1 gene to outside databases

Previous GC identifers: GC14M079152 GC14M075463 GC14M079634 GC14M079636 GC14M080716 GC14M061813


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GTF2A1:
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II
(POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 (PubMed 8224848)).
One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD
subunits.(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

Gene Wiki entry for GTF2A1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTF2A1 gene promoter:
         MyoD   FOXJ2   POU6F1 (c2)   ZID   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GTF2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GTF2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GTF2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q31

GTF2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2A1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M081646:  view genomic region     (about GC identifiers)

Start:
81,641,796 bp from pter      End:
81,687,721 bp from pter
Size:
45,926 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655 (See protein sequence)
Recommended Name: Transcription initiation factor IIA subunit 1  
Size: 376 amino acids; 41514 Da
Subunit: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally
believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with
TBP
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for GTF2A1:
1NVP (3D)    
Secondary accessions: Q3KNQ9
Alternative initiation: 2 isoforms:  P52655-1   P52655-2   

Explore the universe of human proteins at neXtProt for GTF2A1: NX_P52655

Post-translational modifications:

  • The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes
  • proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52655

  • GTF2A1 Protein expression data from MOPED and PaxDb:    About this image 
    GTF2A1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_056943.1  NP_963889.1  

    ENSEMBL proteins: 
     ENSP00000452454   ENSP00000298173   ENSP00000409492  
    Reactome Protein details: P52655
    Human Recombinant Protein Products for GTF2A1: 
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    Uscn Proteins for GTF2A1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005672transcription factor TFIIA complex IDA7724559

    GTF2A1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GTF2A1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009088 TFIIA_b-brl
     IPR009083 TFIIA_a-hlx
     IPR004855 TFIIA_asu/bsu
     IPR013028 TFIIA_asu_N

    Graphical View of Domain Structure for InterPro Entry P52655

    ProtoNet protein and cluster: P52655

    1 Blocks protein family: IPB004855 Transcription factor IIA

    UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655
    Similarity: Belongs to the TFIIA subunit 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF2AA_HUMAN, P52655
    Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
    transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA7724559
    GO:0003713transcription coactivator activity TAS8224850
    GO:0005515protein binding IPI8006019
    GO:0008134transcription factor binding IPI8626665
    GO:0017025TBP-class protein binding IPI7724559
         
    GTF2A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gtf2a1):
     no phenotypic analysis 

    GTF2A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GTF2A1 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/12 pathways (see all 12)
    RNA Polymerase II Pre-transcription Events0.72
    Addition of the third nucleotide on the nascent transcript0.40
    Transcription of the HIV genome0.70
    RNA Polymerase II Promoter Escape0.40
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.40
    RNA Polymerase II Transcription Initiation0.40
    HIV-1 Transcription Initiation0.40
    Addition of the fourth nucleotide on the Nascent Transcript: Second Transition0.40
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex1.00
    Basal transcription factors0.49
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.32
    Protein Acetylation and Deacetylation0.51
    3HIV Infection
    HIV Infection1.00
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Late Phase of HIV Life Cycle
    Late Phase of HIV Life Cycle1.00
    HIV Life Cycle0.90
    5Transcription
    Transcription1.00
    RNA Polymerase II Transcription0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GTF2A1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GTF2A1 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Crosstalk Between CARM1 and ESRs

    1 GeneGo (Thomson Reuters) Pathway for GTF2A1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/19        Reactome Pathways for GTF2A1 (see all 19)
        Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Disease
    HIV Infection


    1         Kegg Pathway  (Kegg details for GTF2A1):
        Basal transcription factors


    GTF2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for GTF2A1 (P526553 ENSP000002981734) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    GTF2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTF2A1
    Search CenterWatch for drugs/clinical trials and news about GTF2A1 / TF2AA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GTF2A1 gene (2 alternative transcripts): 
    NM_015859.3  NM_201595.2  

    Unigene Cluster for GTF2A1:

    General transcription factor IIA, 1, 19/37kDa
    Hs.592334  [show with all ESTs]
    Unigene Representative Sequence: NR_048573
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553612(uc001xvf.1 uc010atb.1 uc001xvg.1) ENST00000298173
    ENST00000434192 ENST00000556268

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GTF2A1:
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    Additional cDNA sequence: 

    AK021641.1 AK025178.1 BC037828.1 BC041410.2 BC050703.1 BC107155.2 BC107156.1 D14886.1 
    D14887.1 NR_048573.1 X75383.1 X77225.1 

    9 DOTS entries:

    DT.454877  DT.408700  DT.100719932  DT.91980156  DT.92415311  DT.100699780  DT.100815776  DT.421315 
    DT.95184899 

    24/159 AceView cDNA sequences (see all 159):

    AK025178 AA662399 BQ923439 X77225 BQ006826 AA811332 BX493028 BU633617 
    BU181924 BQ184527 AK021641 AW024450 X75383 AI538775 AI279371 AA490430 
    BG820646 W31188 BQ215993 BX500812 BF593481 NM_015859 BM479124 BM750235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GTF2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAATTTTAA
    GTF2A1 Expression
    About this image
    See GTF2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GTF2A1

    SOURCE GeneReport for Unigene cluster: Hs.592334
        SABiosciences Custom PCR Arrays for GTF2A1

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GTF2A1 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2a11 , 5 general transcription factor II A, 11, 5 90.69(n)1
    97.07(a)1
      12 (45.02 cM)5
    836021  NM_031391.21  NP_113568.21 
     915559165 
    chicken
    (Gallus gallus)
    Aves GTF2A11 general transcription factor IIA, 1, 19/37kDa 84.57(n)
    90.69(a)
      423389  NM_001031207.2  NP_001026378.2 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2A16
    --
    84(a)
    1 ↔ 1
    1(17893254-17904657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292482 Xenopus laevis transcription factor IIA large subunit-2 more 81.25(n)    AY218795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.246692 Danio rerio mRNA similar to general transcription factor more 75.77(n)    BC048894.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIA-L1 Transcription factor IIA L 47.08(n)
    38.87(a)
      43284  NM_057647.3  NP_476995.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pqn-511 Protein PQN-51 46.13(n)
    33.93(a)
      178893  NM_071954.4  NP_504355.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G592306
    AT1G074806
    (see all 3)
    Transcription factor IIA, alpha/beta subunit
    (see all 3)
    31(a)
    18(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    5(23901555-23902379)
    1(2296023-2299470)
    rice
    (Oryza sativa)
    Liliopsida --
    transcription factor IIA large subunit, putative, ...
    20(a)
    1 → many
    5(12808826-12815325)


    ENSEMBL Gene Tree for GTF2A1 (if available)
    TreeFam Gene Tree for GTF2A1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GTF2A1 gene
    STON22  GTF2A1L2  STON12  STON1-GTF2A1L2  

    GTF2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/721 NCBI SNPs in GTF2A1 are shown (see all 721    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920115011,2
    --81641369(+) TTTGGC/TGGGGG 3 -- ds50010--------
    rs1432048361,2
    --81641370(+) TTGGCA/GGGGGG 3 -- ds50010--------
    rs733422731,2
    C--81641372(+) GGCGGG/AGGGAG 3 -- ds50012Minor allele frequency- A:0.05WA 120
    rs746384151,2
    C--81641425(+) CCCATA/TCCCAG 3 -- ds50010--------
    rs80124661,2
    C,F,H--81641464(+) CTGCTG/ATAGCC 3 -- ds500117Minor allele frequency- A:0.12NS EA NA WA CSA 2054
    rs1482712321,2
    --81641717(+) TGTCAC/TTTTAC 3 -- ds50010--------
    rs71503891,2
    H--81641919(+) TTCAGC/ATGAAT 3 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.00NS EA 420
    rs1411761891,2
    --81641940(+) ATTAAA/GATACC 3 -- ut31 nc-transcript-variant0--------
    rs1507071391,2
    --81641961(+) TATCTC/TCTAAA 3 -- nc-transcript-variantut310--------
    rs1380232891,2
    --81642112(+) ATACTG/TTGGAG 3 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for GTF2A1 (81641796 - 81687721 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GTF2A1
         2 CNVs: 76687 76688

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GTF2A1 for disorders           About GeneDecksing

    OMIM gene information: 600520    OMIM disorders: --

    7 diseases for GTF2A1:    About MalaCards
    herpes simplex    sporadic breast cancer    celiac disease    breast cancer
    ovarian cancer    gastric cancer    immunodeficiency

    2 Novoseek disease relationships for GTF2A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 9.67 1 15081896 (1)
    immunodeficiency 0 1 8151790 (1)

    Human Genome Epidemiology (HuGE) Navigator: GTF2A1 (2 documents)

    Export disorders for GTF2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GTF2A1 gene, integrated from 9 sources (see all 145):
    (articles sorted by number of sources associating them with GTF2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. (PubMed id 8224848)1, 2, 3, 9 Dejong J. and Roeder R.G. (1993)
    2. Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PubMed id 11278496)1, 2, 9 Solow S.... Lieberman P.M. (2001)
    3. Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. (PubMed id 15257296)1, 2, 9 Hoiby T....Stunnenberg H.G. (2004)
    4. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. (PubMed id 16537915)1, 2 Zhou H.... Stunnenberg H.G. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    8. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. (PubMed id 8224850)1, 2 Ma D.... Handa H. (1993)
    9. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. (PubMed id 7958899)1, 9 Ozer J.... Lieberman P.M. (1994)
    10. TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. (PubMed id 17681538)1, 9 Hieb A.R....Goodrich J.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2957 HGNC: 4646 AceView: GTF2A1 Ensembl:ENSG00000165417 euGenes: HUgn2957
    ECgene: GTF2A1 Kegg: 2957 H-InvDB: GTF2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GTF2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GTF2A1 gene:
    Search GeneIP for patents involving GTF2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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