Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GTF2A1 Gene

protein-coding   GIFtS: 61
GCID: GC14M081646

General Transcription Factor IIA, 1, 19/37kDa

(Previous names: glucose regulated protein, 58kD pseudogene)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
General Transcription Factor IIA, 1, 19/37kDa1 2     TFIIA-422 3
TF2A12 3 5     TFIIAL2 3
Glucose Regulated Protein, 58kD Pseudogene1 2     TFIIA2
General Transcription Factor IIA Subunit 12 3     TFIIA Alpha, P552
Transcription Initiation Factor TFIIA 42 KDa Subunit2 3     Transcription Initiation Factor IIA Subunit 12

External Ids:    HGNC: 46461   Entrez Gene: 29572   Ensembl: ENSG000001654177   OMIM: 6005205   UniProtKB: P526553   
ORGUL members:         

Export aliases for GTF2A1 gene to outside databases

Previous GC identifers: GC14M079152 GC14M075463 GC14M079634 GC14M079636 GC14M080716 GC14M061813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GTF2A1 Gene:
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA
polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993
(PubMed 8224848)). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-,
and 12-kD subunits.(supplied by OMIM, Jul 2010)

GeneCards Summary for GTF2A1 Gene:
GTF2A1 (general transcription factor IIA, 1, 19/37kDa) is a protein-coding gene. Diseases associated with GTF2A1 include sporadic breast cancer, and herpes simplex. GO annotations related to this gene include transcription coactivator activity and protein heterodimerization activity. An important paralog of this gene is STON2.

UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

Gene Wiki entry for GTF2A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GTF2A1 gene promoter:
         MyoD   FOXJ2   POU6F1 (c2)   ZID   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GTF2A1 promoter sequence
   Search Chromatin IP Primers for GTF2A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q31

GTF2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2A1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M081646:  view genomic region     (about GC identifiers)

Start:
81,641,796 bp from pter      End:
81,687,721 bp from pter
Size:
45,926 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655 (See protein sequence)
Recommended Name: Transcription initiation factor IIA subunit 1  
Size: 376 amino acids; 41514 Da
Subunit: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally
believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex
with TBP
1 PDB 3D structure from and Proteopedia for GTF2A1:
1NVP (3D)    
Secondary accessions: Q3KNQ9
Alternative initiation: 2 isoforms:  P52655-1   P52655-2   

Explore the universe of human proteins at neXtProt for GTF2A1: NX_P52655

Explore proteomics data for GTF2A1 at MOPED

Post-translational modifications: 

  • The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage
    promotes proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GTF2A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265869.1  NP_056943.1  NP_963889.1  

    ENSEMBL proteins: 
     ENSP00000452454   ENSP00000298173   ENSP00000409492  
    Reactome Protein details: P52655

    GTF2A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GTF2A1
    GenScript Custom Purified and Recombinant Proteins Services for GTF2A1
    Novus Biologicals GTF2A1 Proteins
    Novus Biologicals GTF2A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GTF2A1

    GTF2A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GTF2A1
    OriGene Custom Antibody Services for GTF2A1
    Novus Biologicals GTF2A1 Antibodies
    Abcam antibodies for GTF2A1
    Cloud-Clone Corp. Antibodies for GTF2A1
    ThermoFisher Antibody for GTF2A1
    LSBio Antibodies in human, mouse, rat for GTF2A1

    GTF2A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GTF2A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTF2A1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GTF2A1
    Cloud-Clone Corp. CLIAs for GTF2A1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GTF: General transcription factors

    4 InterPro protein domains:
     IPR009088 TFIIA_b-brl
     IPR009083 TFIIA_a-hlx
     IPR004855 TFIIA_asu/bsu
     IPR013028 TFIIA_asu_N

    Graphical View of Domain Structure for InterPro Entry P52655

    ProtoNet protein and cluster: P52655

    1 Blocks protein domain: IPB004855 Transcription factor IIA

    UniProtKB/Swiss-Prot: TF2AA_HUMAN, P52655
    Similarity: Belongs to the TFIIA subunit 1 family


    GTF2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF2AA_HUMAN, P52655
    Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in
    transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA7724559
    GO:0003713transcription coactivator activity TAS8224850
    GO:0005515protein binding IPI8006019
    GO:0008134transcription factor binding IPI8626665
    GO:0017025TBP-class protein binding IPI7724559
         
    GTF2A1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gtf2a1):
     mortality/aging  no phenotypic analysis 

    GTF2A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2A1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTF2A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GTF2A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GTF2A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GTF2A1:
    hsa-mir-424-5p (MIRT042458), hsa-mir-21-5p (MIRT030695), hsa-mir-96-5p (MIRT027887)

    Block miRNA regulation of human, mouse, rat GTF2A1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GTF2A1:
    hsa-miR-142-3p
    SwitchGear 3'UTR luciferase reporter plasmidGTF2A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GTF2A1
    Predesigned siRNA for gene silencing in human, mouse, rat GTF2A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GTF2A1

    Clone
    Products:
         
    OriGene clones in human, mouse for GTF2A1 (see all 14)
    OriGene ORF clones in mouse, rat for GTF2A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF2A1 (NM_015859)
    Sino Biological Human cDNA Clone for GTF2A1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF2A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GTF2A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GTF2A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TF2AA_HUMAN, P52655: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005672transcription factor TFIIA complex IDA7724559
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    GTF2A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GTF2A1 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    Glucocorticoid Receptor Signaling0.43
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GTF2A1 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Crosstalk Between CARM1 and ESRs

    1 GeneGo (Thomson Reuters) Pathway for GTF2A1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    Selected Reactome Pathways for GTF2A1 (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    2 Kegg Pathways  (Kegg details for GTF2A1):
        Basal transcription factors
    Viral carcinogenesis


    GTF2A1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GTF2A1
    Interactions:

        GeneGlobe Interaction Network for GTF2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GTF2A1 (P526553 ENSP000002981734) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    GTF2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GTF2A1 (TF2AA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GTF2A1 gene (3 alternative transcripts): 
    NM_001278940.1  NM_015859.3  NM_201595.2  

    Unigene Cluster for GTF2A1:

    General transcription factor IIA, 1, 19/37kDa
    Hs.592334  [show with all ESTs]
    Unigene Representative Sequence: NR_048573
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553612(uc001xvf.1 uc010atb.1 uc001xvg.1) ENST00000298173
    ENST00000434192 ENST00000556268
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GTF2A1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GTF2A1:
    hsa-miR-142-3p
    SwitchGear 3'UTR luciferase reporter plasmidGTF2A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GTF2A1
    Predesigned siRNA for gene silencing in human, mouse, rat GTF2A1
    Clone
    Products:
         
    OriGene clones in human, mouse for GTF2A1 (see all 14)
    OriGene ORF clones in mouse, rat for GTF2A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GTF2A1 (NM_015859)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GTF2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF2A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GTF2A1
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF2A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF2A1
      QuantiTect SYBR Green Assays in human, mouse, rat GTF2A1
      QuantiFast Probe-based Assays in human, mouse, rat GTF2A1

    Additional mRNA sequence: 

    AK021641.1 AK025178.1 BC037828.1 BC041410.2 BC050703.1 BC107155.2 BC107156.1 D14886.1 
    D14887.1 NR_048573.1 X75383.1 X77225.1 

    9 DOTS entries:

    DT.454877  DT.408700  DT.100719932  DT.91980156  DT.92415311  DT.100699780  DT.100815776  DT.421315 
    DT.95184899 

    Selected AceView cDNA sequences (see all 159):

    D14886 AW192220 BG820646 BM721365 BQ923439 AI538775 BU181924 BX500812 
    NM_201595 X77225 AA234995 AI279371 AK021641 AI569110 BQ184527 BF593481 
    AW024450 BU633617 AA811332 NM_015859 BQ215993 BG576966 AA490430 BM750235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GTF2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATTTTAA
    GTF2A1 Expression
    About this image


    GTF2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    GTF2A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GTF2A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592334
        Custom PCR Arrays for GTF2A1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GTF2A1
    OriGene qSTAR qPCR primer pairs in human, mouse for GTF2A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF2A1
    QuantiTect SYBR Green Assays in human, mouse, rat GTF2A1
    QuantiFast Probe-based Assays in human, mouse, rat GTF2A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GTF2A1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtf2a11 , 5 general transcription factor II A, 11, 5 90.07(n)1
    95.74(a)1
      12 (45.02 cM)5
    836021  NM_031391.21  NP_113568.21 
     915559165 
    chicken
    (Gallus gallus)
    Aves GTF2A11 general transcription factor IIA, 1, 19/37kDa 84.04(n)
    89.89(a)
      423389  NM_001031207.2  NP_001026378.2 
    lizard
    (Anolis carolinensis)
    Reptilia GTF2A16
    general transcription factor IIA, 1, 19/37kDa
    84(a)
    1 ↔ 1
    1(17893254-17904674)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292482 Xenopus laevis transcription factor IIA large subunit-2 more 81.25(n)    AY218795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.246692 Danio rerio mRNA similar to general transcription factor more 75.77(n)    BC048894.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIA-L6
    Transcription factor IIA L
    34(a)
    1 ↔ 1
    3R(23076834-23082186)


    ENSEMBL Gene Tree for GTF2A1 (if available)
    TreeFam Gene Tree for GTF2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GTF2A1 gene
    STON22  GTF2A1L2  STON12  STON1-GTF2A1L2  

    GTF2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GTF2A1 (see all 818)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356674
    A breast cancer sample4--see VAR_0356672 L V mis40--------
    rs1908134751,2
    C--62676872(+) TTCCAA/GTATAT 2 -- us2k10--------
    rs1920115011,2
    --81641369(+) TTTGGC/TGGGGG 3 -- ds50010--------
    rs1432048361,2
    --81641370(+) TTGGCA/GGGGGG 3 -- ds50010--------
    rs733422731,2
    C,F--81641372(+) GGCGGG/AGGGAG 3 -- ds50012Minor allele frequency- A:0.05WA 120
    rs746384151,2
    C--81641425(+) CCCATA/TCCCAG 3 -- ds50010--------
    rs80124661,2
    C,F,H--81641464(+) CTGCTG/ATAGCC 3 -- ds500117Minor allele frequency- A:0.12NS EA NA WA CSA 2054
    rs1482712321,2
    --81641717(+) TGTCAC/TTTTAC 3 -- ds50010--------
    rs71503891,2
    H--81641919(+) TTCAGC/ATGAAT 3 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.00NS EA 420
    rs1411761891,2
    --81641940(+) ATTAAA/GATACC 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for GTF2A1 (81641796 - 81687721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GTF2A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902118CNV Loss21882294
    nsv902117CNV Loss21882294
    nsv832841CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GTF2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for GTF2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600520    OMIM disorders: --

    14 diseases for GTF2A1:    
    About MalaCards
    sporadic breast cancer    herpes simplex    celiac disease    breast and colorectal cancer
    tonsillitis    hiv-1    ovarian cancer    breast cancer
    malaria    thyroiditis    colorectal cancer    cerebritis
    prostatitis    endotheliitis


    GTF2A1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GTF2A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 9.67 1 15081896 (1)
    immunodeficiency 0 1 8151790 (1)

    Genetic Association Database (GAD): GTF2A1
    Human Genome Epidemiology (HuGE) Navigator: GTF2A1 (2 documents)

    Export disorders for GTF2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GTF2A1 gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with GTF2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. (PubMed id 8224848)1, 2, 3, 9 Dejong J. and Roeder R.G. (Genes Dev. 1993)
    2. Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PubMed id 11278496)1, 2, 9 Solow S.... Lieberman P.M. (J. Biol. Chem. 2001)
    3. Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. (PubMed id 15257296)1, 2, 9 Hoiby T....Stunnenberg H.G. (EMBO J. 2004)
    4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    5. Interaction of polymorphisms in the interleukin 1B-31 and general transcription factor 2A1 genes on the susceptibility to gastric cancer. (PubMed id 17596959)1, 4 Lee K.A....Kim J.W. (Cytokine 2007)
    6. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. (PubMed id 16537915)1, 2 Zhou H.... Stunnenberg H.G. (Mol. Cell. Biol. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    10. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. (PubMed id 8224850)1, 2 Ma D.... Handa H. (Genes Dev. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2957 HGNC: 4646 AceView: GTF2A1 Ensembl:ENSG00000165417 euGenes: HUgn2957
    ECgene: GTF2A1 Kegg: 2957 H-InvDB: GTF2A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GTF2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GTF2A1 gene:
    Search GeneIP for patents involving GTF2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GTF2A1   OriGene RNAi products in human, mouse, rat for GTF2A1  
     OriGene qPCR primer pairs and template standards for GTF2A1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GTF2A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GTF2A1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GTF2A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GTF2A1   OriGene Custom Protein Services for GTF2A1  

     
     
     Block miRNA regulation of human, mouse, rat GTF2A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GTF2A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GTF2A1 Predesigned siRNA for gene silencing in human, mouse, rat GTF2A1
     QuantiFast Probe-based Assays in human, mouse, rat GTF2A1 QuantiTect SYBR Green Assays in human, mouse, rat GTF2A1
     Custom PCR Arrays for GTF2A1 Search Chromatin IP Primers for GTF2A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GTF2A1  GeneGlobe Interaction Network for GTF2A1
     Regulatory tfbs in GTF2A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GTF2A1 GenScript cDNA clones with any tag delivered in your preferred vector for GTF2A1
     GenScript Custom Assay Services for GTF2A1 GenScript Custom overexpressing Cell Line Services for GTF2A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GTF2A1 (TF2AA)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GTF2A1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GTF2A1 antibodies
     GTF2A1 proteins
     GTF2A1 lysates
     Antibodies for GTF2A1
     See all of Abcam's Antibodies, Kits and Proteins for GTF2A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GTF2A1
     Antibodies for GTF2A1
     ELISAs for GTF2A1
     CLIAs for GTF2A1



     Browse ESI BIO Cell Lines and PureStem Progenitors for GTF2A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GTF2A1
     SwitchGear 3'UTR luciferase reporter plasmids for GTF2A1
     SwitchGear Promoter luciferase reporter plasmids for GTF2A1
     ThermoFisher Antibody for GTF2A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GTF2A1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GTF2A1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GTF2A1
     LSBio Antibodies in human, mouse, rat for GTF2A1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GTF2A1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4