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Aliases for GTF2A1 Gene

Aliases for GTF2A1 Gene

  • General Transcription Factor IIA, 1, 19/37kDa 2 3
  • TF2A1 3 4 6
  • Transcription Initiation Factor TFIIA 42 KDa Subunit 3 4
  • Glucose Regulated Protein, 58kD Pseudogene 2 3
  • General Transcription Factor IIA Subunit 1 3 4
  • TFIIA-42 3 4
  • TFIIAL 3 4
  • Transcription Initiation Factor IIA Subunit 1 3
  • TFIIA Alpha, P55 3
  • TFIIA 3

External Ids for GTF2A1 Gene

Summaries for GTF2A1 Gene

Entrez Gene Summary for GTF2A1 Gene

  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

GeneCards Summary for GTF2A1 Gene

GTF2A1 (General Transcription Factor IIA, 1, 19/37kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein heterodimerization activity and transcription coactivator activity. An important paralog of this gene is GTF2A1L.

UniProtKB/Swiss-Prot for GTF2A1 Gene

  • TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Wiki entry for GTF2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2A1 Gene

Genomics for GTF2A1 Gene

Genomic Location for GTF2A1 Gene

81,175,452 bp from pter
81,221,377 bp from pter
45,926 bases
Minus strand

Genomic View for GTF2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTF2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A1 Gene

Regulatory Elements for GTF2A1 Gene

Proteins for GTF2A1 Gene

  • Protein details for GTF2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription initiation factor IIA subunit 1
    Protein Accession:
    Secondary Accessions:
    • Q3KNQ9

    Protein attributes for GTF2A1 Gene

    376 amino acids
    Molecular mass:
    41514 Da
    Quaternary structure:
    • TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP.

    Three dimensional structures from OCA and Proteopedia for GTF2A1 Gene

    Alternative splice isoforms for GTF2A1 Gene


neXtProt entry for GTF2A1 Gene

Proteomics data for GTF2A1 Gene at MOPED

Post-translational modifications for GTF2A1 Gene

  • The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF2A1 Gene

Domains for GTF2A1 Gene

Gene Families for GTF2A1 Gene

  • GTF :General transcription factors

Protein Domains for GTF2A1 Gene


  • Belongs to the TFIIA subunit 1 family.:
    • P52655
genes like me logo Genes that share domains with GTF2A1: view

Function for GTF2A1 Gene

Molecular function for GTF2A1 Gene

UniProtKB/Swiss-Prot Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Ontology (GO) - Molecular Function for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 7724559
GO:0003713 transcription coactivator activity TAS 8224850
GO:0005515 protein binding IPI 25416956
GO:0008134 transcription factor binding IPI 8626665
GO:0017025 TBP-class protein binding IPI 7724559
genes like me logo Genes that share ontologies with GTF2A1: view

Phenotypes for GTF2A1 Gene

genes like me logo Genes that share phenotypes with GTF2A1: view

miRNA for GTF2A1 Gene

miRTarBase miRNAs that target GTF2A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GTF2A1 Gene

Localization for GTF2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A1 Gene

Subcellular locations from

Jensen Localization Image for GTF2A1 Gene COMPARTMENTS Subcellular localization image for GTF2A1 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005672 transcription factor TFIIA complex IDA 7724559
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GTF2A1: view

Pathways for GTF2A1 Gene

genes like me logo Genes that share pathways with GTF2A1: view

Gene Ontology (GO) - Biological Process for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with GTF2A1: view

Transcripts for GTF2A1 Gene

Unigene Clusters for GTF2A1 Gene

General transcription factor IIA, 1, 19/37kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A1 Gene

No ASD Table

Relevant External Links for GTF2A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTF2A1 Gene

mRNA expression in normal human tissues for GTF2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GTF2A1 Gene

SOURCE GeneReport for Unigene cluster for GTF2A1 Gene Hs.592334

genes like me logo Genes that share expressions with GTF2A1: view

Orthologs for GTF2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTF2A1 36
  • 99.56 (n)
  • 99.73 (a)
GTF2A1 37
  • 100 (a)
(Bos Taurus)
Mammalia GTF2A1 36
  • 94.46 (n)
  • 99.11 (a)
GTF2A1 37
  • 96 (a)
(Canis familiaris)
Mammalia GTF2A1 36
  • 93.26 (n)
  • 98.63 (a)
GTF2A1 37
  • 97 (a)
(Mus musculus)
Mammalia Gm5435 37
  • 87 (a)
Gtf2a1 36
  • 90.07 (n)
  • 95.74 (a)
Gtf2a1 16
Gtf2a1 37
  • 96 (a)
(Monodelphis domestica)
Mammalia GTF2A1 37
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia GTF2A1 37
  • 93 (a)
(Rattus norvegicus)
Mammalia Gtf2a1 36
  • 92.11 (n)
  • 98.67 (a)
(Gallus gallus)
Aves GTF2A1 36
  • 84.04 (n)
  • 89.89 (a)
GTF2A1 37
  • 91 (a)
(Anolis carolinensis)
Reptilia GTF2A1 37
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29248 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a1 36
  • 77.87 (n)
  • 82.24 (a)
Str.5955 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1071 36
(Danio rerio)
Actinopterygii Dr.24669 36
gtf2a1 36
  • 71.59 (n)
  • 75.49 (a)
gtf2a1 37
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta TfIIA-L 37
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3030 36
Species with no ortholog for GTF2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF2A1 Gene

Gene Tree for GTF2A1 (if available)
Gene Tree for GTF2A1 (if available)

Paralogs for GTF2A1 Gene

Paralogs for GTF2A1 Gene

genes like me logo Genes that share paralogs with GTF2A1: view

Variants for GTF2A1 Gene

Sequence variations from dbSNP and Humsavar for GTF2A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs728458 -- 81,199,672(-) GATTT(A/G)ACATT intron-variant
rs759939 -- 81,197,109(+) ACTTG(C/G)CATGT intron-variant
rs934127 -- 81,212,559(+) TCTTT(A/G)TTCTC intron-variant
rs1025323 -- 81,198,644(+) ATCCC(A/G)CTATA intron-variant
rs1035947 -- 81,181,973(+) GTGAG(A/C)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2A1 Gene

Variant ID Type Subtype PubMed ID
nsv832841 CNV Gain 17160897
nsv902117 CNV Loss 21882294
nsv902118 CNV Loss 21882294

Relevant External Links for GTF2A1 Gene

HapMap Linkage Disequilibrium report

Disorders for GTF2A1 Gene

(2) Novoseek inferred disease relationships for GTF2A1 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 9.67 1
immunodeficiency 0 1

Relevant External Links for GTF2A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GTF2A1: view

No data available for UniProtKB/Swiss-Prot for GTF2A1 Gene

Publications for GTF2A1 Gene

  1. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. (PMID: 8224848) Dejong J. … Roeder R.G. (Genes Dev. 1993) 2 3 4 23
  2. Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PMID: 11278496) Solow S. … Lieberman P.M. (J. Biol. Chem. 2001) 3 4 23
  3. Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. (PMID: 15257296) Hoiby T. … Stunnenberg H.G. (EMBO J. 2004) 3 4 23
  4. TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. (PMID: 17681538) Hieb A.R. … Goodrich J.A. (J. Mol. Biol. 2007) 3 23
  5. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. (PMID: 8224850) Ma D. … Handa H. (Genes Dev. 1993) 3 4

Products for GTF2A1 Gene

Sources for GTF2A1 Gene

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