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Aliases for GTDC1 Gene

Aliases for GTDC1 Gene

  • Glycosyltransferase Like Domain Containing 1 2 3 5
  • Glycosyltransferase-Like Domain Containing 1 2 3
  • Mannosyltransferase-Like Protein Xa 3 4
  • Mat-Xa 3 4
  • Mannosyltransferase Candidate 3
  • Glycosyltransferase-Like 1 3
  • Mannosyltransferase-Like 2
  • Hmat-Xa 3

External Ids for GTDC1 Gene

Previous GeneCards Identifiers for GTDC1 Gene

  • GC02M144915
  • GC02M144537
  • GC02M144419
  • GC02M144703
  • GC02M136694

Summaries for GTDC1 Gene

GeneCards Summary for GTDC1 Gene

GTDC1 (Glycosyltransferase Like Domain Containing 1) is a Protein Coding gene. Diseases associated with GTDC1 include Colon Adenocarcinoma. GO annotations related to this gene include transferase activity, transferring glycosyl groups and transferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTDC1 Gene

Genomics for GTDC1 Gene

Regulatory Elements for GTDC1 Gene

Enhancers for GTDC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GTDC1 on UCSC Golden Path with GeneCards custom track

Promoters for GTDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GTDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GTDC1 Gene

Chromosome:
2
Start:
143,938,068 bp from pter
End:
144,332,568 bp from pter
Size:
394,501 bases
Orientation:
Minus strand

Genomic View for GTDC1 Gene

Genes around GTDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTDC1 Gene

Proteins for GTDC1 Gene

  • Protein details for GTDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4AE62-GTDC1_HUMAN
    Recommended name:
    Glycosyltransferase-like domain-containing protein 1
    Protein Accession:
    Q4AE62
    Secondary Accessions:
    • A0A087X2H5
    • A8K5P2
    • D3DP81
    • G1UFN1
    • G5EA49
    • H7BYJ5
    • Q53SM7
    • Q53TC5
    • Q6P7E7
    • Q6PJB6
    • Q6WKW6
    • Q9HAE5

    Protein attributes for GTDC1 Gene

    Size:
    458 amino acids
    Molecular mass:
    52597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93131.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13904.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GTDC1 Gene

neXtProt entry for GTDC1 Gene

Proteomics data for GTDC1 Gene at MOPED

Post-translational modifications for GTDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTDC1 Gene

Domains & Families for GTDC1 Gene

Gene Families for GTDC1 Gene

Protein Domains for GTDC1 Gene

Suggested Antigen Peptide Sequences for GTDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4AE62

UniProtKB/Swiss-Prot:

GTDC1_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with GTDC1: view

Function for GTDC1 Gene

genes like me logo Genes that share phenotypes with GTDC1: view

Animal Model Products

miRNA for GTDC1 Gene

miRTarBase miRNAs that target GTDC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTDC1 Gene

Localization for GTDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTDC1 Gene COMPARTMENTS Subcellular localization image for GTDC1 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GTDC1 Gene

Pathways & Interactions for GTDC1 Gene

SuperPathways for GTDC1 Gene

No Data Available

Interacting Proteins for GTDC1 Gene

Gene Ontology (GO) - Biological Process for GTDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GTDC1 Gene

Drugs & Compounds for GTDC1 Gene

No Compound Related Data Available

Transcripts for GTDC1 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9:

Relevant External Links for GTDC1 Gene

GeneLoc Exon Structure for
GTDC1
ECgene alternative splicing isoforms for
GTDC1

Expression for GTDC1 Gene

mRNA expression in normal human tissues for GTDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTDC1 Gene

This gene is overexpressed in Platelet (52.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GTDC1 Gene



SOURCE GeneReport for Unigene cluster for GTDC1 Gene Hs.44780

mRNA Expression by UniProt/SwissProt for GTDC1 Gene

Q4AE62-GTDC1_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in the lung, brain, spleen, testis, placenta. ovary, pancreas, spleen and peripheral blood leukocytes. Expressed at low level in the colon, small intestine, kidney, skeletal muscle and thymus. Expressed at high level in colon adenocarcinoma.
genes like me logo Genes that share expression patterns with GTDC1: view

Protein tissue co-expression partners for GTDC1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for GTDC1 Gene

Orthologs for GTDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTDC1 35
  • 89.89 (n)
  • 85.25 (a)
GTDC1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GTDC1 35
  • 89.74 (n)
  • 88.57 (a)
GTDC1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtdc1 35
  • 81.98 (n)
  • 81.76 (a)
Gtdc1 16
Gtdc1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GTDC1 35
  • 99.56 (n)
  • 99.56 (a)
GTDC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtdc1 35
  • 81.15 (n)
  • 76.86 (a)
oppossum
(Monodelphis domestica)
Mammalia GTDC1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTDC1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTDC1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTDC1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtdc1 35
  • 68.06 (n)
  • 68.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9460 35
zebrafish
(Danio rerio)
Actinopterygii gtdc1 35
  • 63.33 (n)
  • 63.72 (a)
gtdc1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009573 35
  • 56.01 (n)
  • 51.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15914 35
  • 55.52 (n)
  • 54.26 (a)
CG15914 36
  • 48 (a)
OneToOne
Species with no ortholog for GTDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTDC1 Gene

ENSEMBL:
Gene Tree for GTDC1 (if available)
TreeFam:
Gene Tree for GTDC1 (if available)

Paralogs for GTDC1 Gene

(1) SIMAP similar genes for GTDC1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GTDC1: view

No data available for Paralogs for GTDC1 Gene

Variants for GTDC1 Gene

Sequence variations from dbSNP and Humsavar for GTDC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3731958 - 144,141,992(+) TTTCC(A/C)ATGGA reference, missense
rs714592 -- 144,095,968(+) GCAGT(A/C)TGAAA intron-variant
rs1560222 -- 144,046,388(+) CCACT(A/G)ttttg intron-variant
rs1560223 -- 144,056,095(+) gcTAT(A/G)CTATA intron-variant
rs1560224 -- 144,111,477(+) CTTTT(A/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTDC1 Gene

Variant ID Type Subtype PubMed ID
esv2720915 CNV Deletion 23290073
nsv834396 CNV Gain 17160897
esv271681 CNV Insertion 20981092

Variation tolerance for GTDC1 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GTDC1 Gene

Disorders for GTDC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTDC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon adenocarcinoma
  • adenocarcinoma of colon
- elite association - COSMIC cancer census association via MalaCards
Search GTDC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GTDC1

Genetic Association Database (GAD)
GTDC1
Human Genome Epidemiology (HuGE) Navigator
GTDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTDC1
genes like me logo Genes that share disorders with GTDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTDC1 Gene

Publications for GTDC1 Gene

  1. Cloning and expression of human GTDC1 gene (glycosyltransferase-like domain containing 1) from human fetal library. (PMID: 15068588) Zhao E. … Mao Y.-M. (DNA Cell Biol. 2004) 2 3 4 23 67
  2. Remarkable Expression in the Colon Adenocarcinoma of Hmat-Xa, a Human Mannosyltransferase-Like Gene, That Is Homologous to Drosophila Gene GC15914. (PMID: 21821951) Shimono N. … Nishikawa Y. (Biosci. Biotechnol. Biochem. 2011) 2 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for GTDC1 Gene

Sources for GTDC1 Gene

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