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Aliases for GTDC1 Gene

Aliases for GTDC1 Gene

  • Glycosyltransferase Like Domain Containing 1 2 3 5
  • Mannosyltransferase-Like Protein Xa 3 4
  • Mat-Xa 3 4
  • Glycosyltransferase-Like Domain-Containing Protein 1 3
  • Glycosyltransferase-Like Domain Containing 1 2
  • Mannosyltransferase Candidate 3
  • Glycosyltransferase-Like 1 3
  • Mannosyltransferase-Like 2
  • Hmat-Xa 3

External Ids for GTDC1 Gene

Previous GeneCards Identifiers for GTDC1 Gene

  • GC02M144915
  • GC02M144537
  • GC02M144419
  • GC02M144703
  • GC02M136694

Summaries for GTDC1 Gene

GeneCards Summary for GTDC1 Gene

GTDC1 (Glycosyltransferase Like Domain Containing 1) is a Protein Coding gene. Diseases associated with GTDC1 include Colon Adenocarcinoma. GO annotations related to this gene include transferase activity, transferring glycosyl groups and transferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTDC1 Gene

Genomics for GTDC1 Gene

Regulatory Elements for GTDC1 Gene

Enhancers for GTDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F144364 0.7 FANTOM5 ENCODE 14 -32.5 -32523 1.5 HDGF SCRT1 MTA2 EP300 RELA ZNF366 EED IKZF1 GTDC1 ZEB2 GC02M144385
GH02F144356 1.2 FANTOM5 Ensembl 13.2 -24.1 -24133 0.6 ZNF639 L3MBTL2 HLF RELA FOSL1 GATA2 POLR2A SMARCA4 NR2F6 GTDC1 ZEB2 GC02M144385
GH02F144370 1.1 Ensembl ENCODE 12.3 -40.1 -40109 5.0 ATF1 PKNOX1 MLX JUNB PPARG MBD2 MEF2D SMARCA4 MYNN HMBOX1 GTDC1 LOC101928386 GC02M144385
GH02F144376 1.1 FANTOM5 Ensembl ENCODE 12.3 -47.7 -47733 7.4 TBL1XR1 BMI1 CBX5 ETV6 CREM CBFB JUNB TBX21 SMARCA4 IKZF1 GTDC1 ZEB2 ZEB2-AS1 LOC101928386 GC02M144385
GH02F144357 1.3 FANTOM5 Ensembl ENCODE 11.7 -26.0 -26045 3.0 ATF1 WRNIP1 CBX5 FOS KDM4B GTF2B JUNB MBD2 MAFF SMARCA4 GTDC1 ZEB2 GC02M144385
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GTDC1 on UCSC Golden Path with GeneCards custom track

Promoters for GTDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001546984 568 2800 HDGF ARNT CREB3L1 DMAP1 ZNF2 ZNF143 ZNF263 SP3 SP5 REST

Genomic Location for GTDC1 Gene

143,938,068 bp from pter
144,332,568 bp from pter
394,501 bases
Minus strand

Genomic View for GTDC1 Gene

Genes around GTDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTDC1 Gene

Proteins for GTDC1 Gene

  • Protein details for GTDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycosyltransferase-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A0A087X2H5
    • A8K5P2
    • D3DP81
    • G1UFN1
    • G5EA49
    • H7BYJ5
    • Q53SM7
    • Q53TC5
    • Q6P7E7
    • Q6PJB6
    • Q6WKW6
    • Q9HAE5

    Protein attributes for GTDC1 Gene

    458 amino acids
    Molecular mass:
    52597 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAX93131.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13904.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GTDC1 Gene

neXtProt entry for GTDC1 Gene

Post-translational modifications for GTDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GTDC1 Gene

Domains & Families for GTDC1 Gene

Gene Families for GTDC1 Gene

Protein Domains for GTDC1 Gene

Suggested Antigen Peptide Sequences for GTDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with GTDC1: view

Function for GTDC1 Gene

Gene Ontology (GO) - Molecular Function for GTDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with GTDC1: view
genes like me logo Genes that share phenotypes with GTDC1: view

Animal Model Products

miRNA for GTDC1 Gene

miRTarBase miRNAs that target GTDC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTDC1 Gene

Localization for GTDC1 Gene

Subcellular locations from

Jensen Localization Image for GTDC1 Gene COMPARTMENTS Subcellular localization image for GTDC1 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GTDC1 Gene

Pathways & Interactions for GTDC1 Gene

SuperPathways for GTDC1 Gene

No Data Available

Interacting Proteins for GTDC1 Gene

Selected Interacting proteins: Q4AE62-GTDC1_HUMAN for GTDC1 Gene via IID

Gene Ontology (GO) - Biological Process for GTDC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for GTDC1 Gene

Transcripts for GTDC1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -

Relevant External Links for GTDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTDC1 Gene

mRNA expression in normal human tissues for GTDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTDC1 Gene

This gene is overexpressed in Platelet (52.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTDC1 Gene

Protein tissue co-expression partners for GTDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GTDC1 Gene:


SOURCE GeneReport for Unigene cluster for GTDC1 Gene:


mRNA Expression by UniProt/SwissProt for GTDC1 Gene:

Tissue specificity: Ubiquitous. Expressed at high levels in the lung, brain, spleen, testis, placenta. ovary, pancreas, spleen and peripheral blood leukocytes. Expressed at low level in the colon, small intestine, kidney, skeletal muscle and thymus. Expressed at high level in colon adenocarcinoma.
genes like me logo Genes that share expression patterns with GTDC1: view

Primer Products

No data available for mRNA differential expression in normal tissues for GTDC1 Gene

Orthologs for GTDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTDC1 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia GTDC1 34 35
  • 89.89 (n)
(Canis familiaris)
Mammalia GTDC1 34 35
  • 89.74 (n)
(Mus musculus)
Mammalia Gtdc1 34 16 35
  • 81.98 (n)
(Rattus norvegicus)
Mammalia Gtdc1 34
  • 81.15 (n)
(Monodelphis domestica)
Mammalia GTDC1 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GTDC1 35
  • 69 (a)
(Gallus gallus)
Aves GTDC1 35
  • 62 (a)
(Anolis carolinensis)
Reptilia GTDC1 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtdc1 34
  • 68.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9460 34
(Danio rerio)
Actinopterygii gtdc1 34 35
  • 63.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009573 34
  • 56.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15914 34 35
  • 55.52 (n)
Species where no ortholog for GTDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTDC1 Gene

Gene Tree for GTDC1 (if available)
Gene Tree for GTDC1 (if available)

Paralogs for GTDC1 Gene

(1) SIMAP similar genes for GTDC1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GTDC1: view

No data available for Paralogs for GTDC1 Gene

Variants for GTDC1 Gene

Sequence variations from dbSNP and Humsavar for GTDC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1012272 -- 144,235,634(-) ATTCC(A/G)TCCTG intron-variant
rs10167861 -- 144,225,721(+) CATCC(A/G)TGAAG intron-variant
rs10173322 -- 144,149,611(+) AGTAC(A/T)AGTAA intron-variant
rs10183682 -- 144,300,998(+) TCTGA(C/T)CATCT intron-variant
rs10183920 -- 144,292,057(+) ctgag(C/T)gttag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GTDC1 Gene

Variant ID Type Subtype PubMed ID
esv2720915 CNV deletion 23290073
esv3592760 CNV loss 21293372
esv3592761 CNV loss 21293372
esv3592762 CNV loss 21293372
esv3592763 CNV loss 21293372
nsv1013338 CNV loss 25217958
nsv1072981 CNV deletion 25765185
nsv1122010 CNV deletion 24896259
nsv1133486 CNV deletion 24896259
nsv473668 CNV novel sequence insertion 20440878
nsv477437 CNV novel sequence insertion 20440878
nsv479611 CNV novel sequence insertion 20440878
nsv834396 CNV gain 17160897

Variation tolerance for GTDC1 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTDC1 Gene

Disorders for GTDC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTDC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon adenocarcinoma
  • adenocarcinoma of colon
- elite association - COSMIC cancer census association via MalaCards
Search GTDC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GTDC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GTDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTDC1 Gene

Publications for GTDC1 Gene

  1. Cloning and expression of human GTDC1 gene (glycosyltransferase-like domain containing 1) from human fetal library. (PMID: 15068588) Zhao E. … Mao Y.-M. (DNA Cell Biol. 2004) 2 3 4 22 64
  2. Remarkable Expression in the Colon Adenocarcinoma of Hmat-Xa, a Human Mannosyltransferase-Like Gene, That Is Homologous to Drosophila Gene GC15914. (PMID: 21821951) Shimono N. … Nishikawa Y. (Biosci. Biotechnol. Biochem. 2011) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. (PMID: 19826048) Akbari M.R. … Narod S.A. (Cancer Res. 2009) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for GTDC1 Gene

Sources for GTDC1 Gene

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