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Aliases for GSX2 Gene

Aliases for GSX2 Gene

  • GS Homeobox 2 2 3 5
  • Genetic-Screened Homeobox 2 3 4
  • Homeobox Protein GSH-2 3 4
  • GSH2 3 4

External Ids for GSX2 Gene

Previous GeneCards Identifiers for GSX2 Gene

  • GC04P054661
  • GC04P054966
  • GC04P050913

Summaries for GSX2 Gene

GeneCards Summary for GSX2 Gene

GSX2 (GS Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD3.

UniProtKB/Swiss-Prot for GSX2 Gene

  • During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5-CNAATTAG-3 DNA sequence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSX2 Gene

Genomics for GSX2 Gene

Regulatory Elements for GSX2 Gene

Enhancers for GSX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSX2 Gene

Chromosome:
4
Start:
54,099,523 bp from pter
End:
54,102,505 bp from pter
Size:
2,983 bases
Orientation:
Plus strand

Genomic View for GSX2 Gene

Genes around GSX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSX2 Gene

Proteins for GSX2 Gene

  • Protein details for GSX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM3-GSX2_HUMAN
    Recommended name:
    GS homeobox 2
    Protein Accession:
    Q9BZM3

    Protein attributes for GSX2 Gene

    Size:
    304 amino acids
    Molecular mass:
    32031 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GSX2 Gene

Proteomics data for GSX2 Gene at MOPED

Post-translational modifications for GSX2 Gene

No Post-translational modifications

Other Protein References for GSX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSX2 Gene

Domains & Families for GSX2 Gene

Gene Families for GSX2 Gene

Suggested Antigen Peptide Sequences for GSX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZM3

UniProtKB/Swiss-Prot:

GSX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with GSX2: view

Function for GSX2 Gene

Molecular function for GSX2 Gene

UniProtKB/Swiss-Prot Function:
During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5-CNAATTAG-3 DNA sequence.
genes like me logo Genes that share phenotypes with GSX2: view

Animal Models for GSX2 Gene

MGI Knock Outs for GSX2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GSX2 Gene

Localization for GSX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSX2 Gene COMPARTMENTS Subcellular localization image for GSX2 gene
Compartment Confidence
nucleus 5
chloroplast 1
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for GSX2 Gene

Pathways & Interactions for GSX2 Gene

SuperPathways for GSX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GSX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007389 pattern specification process IEA --
GO:0007417 central nervous system development IEA --
genes like me logo Genes that share ontologies with GSX2: view

No data available for Pathways by source and SIGNOR curated interactions for GSX2 Gene

Drugs & Compounds for GSX2 Gene

No Compound Related Data Available

Transcripts for GSX2 Gene

Unigene Clusters for GSX2 Gene

GS homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSX2 Gene

No ASD Table

Relevant External Links for GSX2 Gene

GeneLoc Exon Structure for
GSX2
ECgene alternative splicing isoforms for
GSX2

Expression for GSX2 Gene

mRNA expression in normal human tissues for GSX2 Gene

mRNA differential expression in normal tissues according to GTEx for GSX2 Gene

This gene is overexpressed in Brain - Amygdala (x6.9), Brain - Putamen (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.0).

SOURCE GeneReport for Unigene cluster for GSX2 Gene Hs.371899

genes like me logo Genes that share expression patterns with GSX2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GSX2 Gene

Orthologs for GSX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSX2 35
  • 89.69 (n)
  • 93.42 (a)
GSX2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSX2 35
  • 84.13 (n)
  • 84.35 (a)
GSX2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsx2 35
  • 85.09 (n)
  • 89.14 (a)
Gsx2 16
Gsx2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GSX2 35
  • 99.34 (n)
  • 99.34 (a)
GSX2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsx2 35
  • 85.48 (n)
  • 89.44 (a)
oppossum
(Monodelphis domestica)
Mammalia GSX2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSX2 35
  • 77.63 (n)
  • 81.58 (a)
lizard
(Anolis carolinensis)
Reptilia GSX2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gsx2 35
  • 71.23 (n)
  • 74.27 (a)
zebrafish
(Danio rerio)
Actinopterygii gsx2 35
  • 69.71 (n)
  • 73.86 (a)
gsx2 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ind 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for GSX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSX2 Gene

ENSEMBL:
Gene Tree for GSX2 (if available)
TreeFam:
Gene Tree for GSX2 (if available)

Paralogs for GSX2 Gene

(6) SIMAP similar genes for GSX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSX2: view

Variants for GSX2 Gene

Sequence variations from dbSNP and Humsavar for GSX2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs13144341 - 54,100,663(+) TTAAG(A/G)GCCAG reference, missense
rs1132998 -- 54,100,752(+) CACCA(C/T)CACCA reference, synonymous-codon
rs2278141 -- 54,101,191(+) CACGG(A/C)GGATA intron-variant
rs2278142 -- 54,101,542(+) CTTGC(A/C)CGAGC intron-variant
rs3194383 -- 54,100,500(+) CCGTC(C/T)CGCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GSX2 Gene

Variant ID Type Subtype PubMed ID
nsv879018 CNV Loss 21882294

Variation tolerance for GSX2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSX2 Gene

HapMap Linkage Disequilibrium report
GSX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSX2 Gene

Disorders for GSX2 Gene

Relevant External Links for GSX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSX2

No disorders were found for GSX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSX2 Gene

Publications for GSX2 Gene

  1. Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13). (PMID: 11861295) Cools J. … Marynen P. (Blood 2002) 2 3 23 67
  2. Heterozygous truncating mutation in the human homeobox gene GSH2 has no discernable phenotypic effect. (PMID: 12205114) Dauwerse J.G. … Peters D.J. (J. Med. Genet. 2002) 2 3
  3. 4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset. (PMID: 25816740) Di Giacomo D. … Mecucci C. (Br. J. Haematol. 2015) 3
  4. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3
  5. The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors. (PMID: 22242181) MAcndez-GA^mez H.R. … Vicario-AbejA^n C. (PLoS ONE 2012) 3

Products for GSX2 Gene

Sources for GSX2 Gene

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