GSX2 Gene
protein-coding GIFtS : 43
GCID: GC04 P054966
GS homeobox 2
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Aliasesfor GSX2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases GS Homeobox 2 1 2 Homeobox Protein GSH-22 3 GSH22 3 Gsh21
Export aliases for GSX2 gene to outside databases Previous GC identifers: GC04P054661 GC04P050913
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Summariesfor GSX2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: GSX2_HUMAN, Q9BZM3 Function : Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity)
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Genomic Viewsfor GSX2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_022853.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the GSX2 gene promoter: AREB6 PPAR-gamma1 POU2F1 POU2F1a Nkx2-2 AP-2beta ZID PPAR-gamma2 AP-2gamma AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for GSX2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat GSX2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12 GSX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P054966: view genomic region
(about GC identifiers )
Start:
54,965,690 bp from pter
End:
54,968,672 bp from pter
Size:
2,983 bases
Orientation:
plus strand
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Proteinsfor GSX2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: GSX2_HUMAN, Q9BZM3 (See
protein sequence )Recommended Name: GS homeobox 2 Size : 304 amino acids; 32031 Da
Subcellular location : Nucleus (By similarity)Explore the universe of human proteins at neXtProt for GSX2: NX_Q9BZM3 GSX2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_573574.1 ENSEMBL proteins: ENSP00000319118 ENSP00000422213 Human Recombinant Protein Products for GSX2: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
GSX2 for ontologies About GeneDecksing GSX2 Antibody Products: Assay Products for GSX2:
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Protein
Domains / Familiesfor GSX2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
GSX2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BZM3 ProtoNet protein and cluster: Q9BZM3
1 Blocks protein family : IPB000047 Lambda and other repressor helix-turn-helix signature UniProtKB/Swiss-Prot: GSX2_HUMAN, Q9BZM3 Similarity : Belongs to the Antp homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor GSX2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: GSX2_HUMAN, Q9BZM3 Function : Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
-- -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
GSX2 for ontologies About GeneDecksing Phenotypes: 8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Gsx2) :
GSX2 for phenotypes About GeneDecksing Animal Models: Mouse knock-outs for GSX2: Gsx2 tm1Ssp Gsx2 tm2.2Kc Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for GSX2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for GSX2OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GSX2 (NM_133267 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSX2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GSX2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSX2
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Pathways & Interactionsfor GSX2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSX2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for GSX2 (Q9BZM3 3 ENSP00000319118 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002087 regulation of respiratory gaseous exchange by neurological system process
IEA -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0007275 multicellular organismal development
-- -- GO:0007389 pattern specification process
-- -- GO:0007417 central nervous system development
-- --
GSX2 for ontologies About GeneDecksing
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Drugs & Compoundsfor GSX2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for GSX2 Search CenterWatch for drugs/clinical trials and news about GSX2
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Transcriptsfor GSX2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for GSX2 gene: NM_133267.2 Unigene Cluster for GSX2:
GS homeobox 2 Hs.371899 [show with all ESTs ] Unigene Representative Sequence: AB028838 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000507839 ENST00000326902 (uc010igp.1 ) ENST00000503800 ENST00000548609 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for GSX2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for GSX2OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GSX2 (NM_133267 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSX2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GSX2
Additional cDNA sequence: AB028838.1 BC075089.2 BC075090.2 EU596451.1
2 DOTS entries : DT.109238 DT.40295422
24/36 AceView cDNA sequences (see all 36 ):
BX113485 AI360912 CB054287 AA485025 AI357521 AA744807 AI356125 NM_133267 BX096763 BC075089 CB054288 BE551998 BF508282 AB028838 AI971447 AA485198 AI678083 AW204644 AI422187 AA485095 BC075090 AI937017 AI934486 AI797226 GeneLoc Exon Structure
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Expression for GSX2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GSX2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACCTGTCTCAbout this image GSX2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See GSX2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for GSX2 SOURCE GeneReport for Unigene cluster: Hs.371899 SABiosciences Custom PCR Arrays for GSX2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for GSX2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat GSX2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat GSX2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat GSX2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSX2
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Orthologsfor GSX2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for GSX2 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for GSX2 (if available)TreeFam Gene Tree for GSX2 (if available)
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Paralogsfor GSX2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for GSX2 gene GSX1 2 HOXA7 2 HOXA1 2 HOXD1 2 HOXA2 2 HOXB3 2 HOXC6 2 HOXB5 2 HOXC5 2 HOXB4 2 HOXA5 2 HOXA4 2 HOXD3 2 HOXA6 2 HOXC8 2 HOXA3 2 HOXD8 2 HOXB1 2 HOXB6 2 HOXB8 2 HOXD4 2 HOXB2 2 HOXB7 2 PDX1 2 HOXC4 2 7 SIMAP similar genes for GSX2 using alignment to 3 protein entries: GSX2_HUMAN (see all proteins ):HOXC13 HOX B6 MEOX1 HOXA4 HOXB1 NKX2-5 GSX1
GSX2 for paralogs About GeneDecksing
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Genomic Variantsfor GSX2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing GSX2
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Disorders
/ Diseasesfor GSX2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
GSX2 for disorders About GeneDecksing 3 diseases for GSX2 : About MalaCards myeloid leukemia leukemia neuronitis Export disorders for GSX2 gene to outside databases
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Publicationsfor GSX2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for GSX2 gene integrated from 9 sources (see top 10 ): (articles sorted by number of sources associating them with GSX2) Utopia : connect your pdf to the dynamic world of online information
Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13). (PubMed id 11861295) 1 , 3, 9 Cools J....Marynen P. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Heterozygous truncating mutation in the human homeobox gene GSH2 has no discernable phenotypic effect. (PubMed id 12205114) 1 , 3 Dauwerse J.G....Peters D.J. (2002) The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors. (PubMed id 22242181) 1 Mendez-Gomez H.R. and Vicario-Abejon C. (2012) MicroRNA-9 regulates neurogenesis in mouse telencepha lon by targeting multiple transcription factors. (PubMed id 21368052) 1 Shibata M....Aizawa S. (2011) Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates. (PubMed id 19709628) 1 Waclaw R.R....Campbell K. (2009) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147) 1 Wu C....Li S.S. (2007) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Cloning and expression analysis of the anterior parahox genes, Gsh1 and Gsh2 from Xenopus tropicalis. (PubMed id 19097192) 9 Illes J.C....Isaacs H.V. (2009) The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. (PubMed id 11060228) 9 Corbin J.G....Fishell G. (2000) Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression. (PubMed id 15295031) 9 Jensen J.B....Parmar M. (2004) Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. (PubMed id 14627641) 9 Stenman J.M....Campbell K. (2003)
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External Searches for GSX2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing GSX2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing GSX2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing GSX2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for GSX2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for GSX2 gene: Search GeneIP for patents involving GSX2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor GSX2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for GSX2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for GSX2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for GSX2 OriGene Protein Over-expression Lysate for GSX2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for GSX2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for GSX2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for GSX2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for GSX2 OriGene Custom Protein Services for GSX2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSX2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing GSX2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat GSX2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat GSX2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat GSX2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat GSX2
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GSX2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSX2
Search ThermoFisher Antibodies for GSX2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GSX2
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Aliases for GSX2
Databases for GSX2
Disorders / Diseases for GSX2
Domains / Families for GSX2
Drugs / Compounds for GSX2
Expression for GSX2
Function for GSX2
Genomic Views for GSX2
Intellectual Property for GSX2
Orthologs for GSX2
Paralogs for GSX2
Pathways / Interactions for GSX2
Products for GSX2
Proteins for GSX2
Publications for GSX2
Search Box for GSX2
Summaries for GSX2
Transcripts for GSX2
Variants for GSX2
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