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Aliases for GSX2 Gene

Aliases for GSX2 Gene

  • GS Homeobox 2 2 3
  • Homeobox Protein GSH-2 3 4
  • GSH2 3 4

External Ids for GSX2 Gene

Previous GeneCards Identifiers for GSX2 Gene

  • GC04P054661
  • GC04P054966
  • GC04P050913

Summaries for GSX2 Gene

GeneCards Summary for GSX2 Gene

GSX2 (GS Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX1.

UniProtKB/Swiss-Prot for GSX2 Gene

  • Probable transcription factor that binds to the DNA sequence 5-CNAATTAG-3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSX2 Gene

Genomics for GSX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GSX2 Gene

54,099,523 bp from pter
54,102,505 bp from pter
2,983 bases
Plus strand

Genomic View for GSX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSX2 Gene

Proteins for GSX2 Gene

  • Protein details for GSX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GS homeobox 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for GSX2 Gene

    304 amino acids
    Molecular mass:
    32031 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GSX2 Gene

Proteomics data for GSX2 Gene at MOPED

Post-translational modifications for GSX2 Gene

No Post-translational modifications

Other Protein References for GSX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSX2 Gene

Domains for GSX2 Gene

Gene Families for GSX2 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for GSX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZM3
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with GSX2: view

Function for GSX2 Gene

Molecular function for GSX2 Gene

UniProtKB/Swiss-Prot Function: Probable transcription factor that binds to the DNA sequence 5-CNAATTAG-3.

Gene Ontology (GO) - Molecular Function for GSX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with GSX2: view
genes like me logo Genes that share phenotypes with GSX2: view

Animal Models for GSX2 Gene

MGI Knock Outs for GSX2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GSX2 Gene

Localization for GSX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSX2 Gene

Subcellular locations from

Jensen Localization Image for GSX2 Gene COMPARTMENTS Subcellular localization image for GSX2 gene
Compartment Confidence
nucleus 3
chloroplast 2
cytosol 1

Gene Ontology (GO) - Cellular Components for GSX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with GSX2: view

Pathways for GSX2 Gene

SuperPathways for GSX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GSX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007389 pattern specification process --
GO:0007417 central nervous system development --
genes like me logo Genes that share ontologies with GSX2: view

No data available for Pathways by source for GSX2 Gene

Transcripts for GSX2 Gene

Unigene Clusters for GSX2 Gene

GS homeobox 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSX2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GSX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSX2 Gene

No ASD Table

Relevant External Links for GSX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSX2 Gene

mRNA expression in normal human tissues for GSX2 Gene

mRNA differential expression in normal tissues according to GTEx for GSX2 Gene

This gene is overexpressed in Brain - Amygdala (6.9), Brain - Putamen (basal ganglia) (5.2), and Brain - Caudate (basal ganglia) (4.0).

SOURCE GeneReport for Unigene cluster for GSX2 Gene Hs.371899

genes like me logo Genes that share expressions with GSX2: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for GSX2 Gene

Orthologs for GSX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GSX2 35
  • 99.34 (n)
  • 99.34 (a)
GSX2 36
  • 99 (a)
(Bos Taurus)
Mammalia GSX2 35
  • 89.69 (n)
  • 93.42 (a)
GSX2 36
  • 93 (a)
(Canis familiaris)
Mammalia GSX2 35
  • 84.13 (n)
  • 84.35 (a)
GSX2 36
  • 83 (a)
(Mus musculus)
Mammalia Gsx2 35
  • 85.09 (n)
  • 89.14 (a)
Gsx2 16
Gsx2 36
  • 89 (a)
(Monodelphis domestica)
Mammalia GSX2 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Gsx2 35
  • 85.48 (n)
  • 89.44 (a)
(Gallus gallus)
Aves GSX2 35
  • 77.63 (n)
  • 81.58 (a)
(Anolis carolinensis)
Reptilia GSX2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gsx2 35
  • 71.23 (n)
  • 74.27 (a)
(Danio rerio)
Actinopterygii gsx2 35
  • 69.71 (n)
  • 73.86 (a)
gsx2 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta ind 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for GSX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSX2 Gene

Gene Tree for GSX2 (if available)
Gene Tree for GSX2 (if available)

Paralogs for GSX2 Gene

Selected SIMAP similar genes for GSX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSX2: view

Variants for GSX2 Gene

Sequence variations from dbSNP and Humsavar for GSX2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1132998 -- 54,100,752(+) CACCA(C/T)CACCA synonymous-codon, reference
rs2278141 -- 54,101,191(+) CACGG(A/C)GGATA intron-variant
rs2278142 -- 54,101,542(+) CTTGC(A/C)CGAGC intron-variant
rs3194383 -- 54,100,500(+) CCGTC(C/T)CGCAA reference, synonymous-codon
rs4293842 -- 54,098,161(+) CAGAG(G/T)AGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GSX2 Gene

Variant ID Type Subtype PubMed ID
nsv879018 CNV Loss 21882294

Relevant External Links for GSX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSX2 Gene

Disorders for GSX2 Gene

No disorders were found for GSX2 Gene.

No data available for UniProtKB/Swiss-Prot for GSX2 Gene

Publications for GSX2 Gene

  1. Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13). (PMID: 11861295) Cools J. … Marynen P. (Blood 2002) 2 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Heterozygous truncating mutation in the human homeobox gene GSH2 has no discernable phenotypic effect. (PMID: 12205114) Dauwerse J.G. … Peters D.J. (J. Med. Genet. 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. (PMID: 11060228) Corbin J.G. … Fishell G. (Development 2000) 23

Products for GSX2 Gene

Sources for GSX2 Gene

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