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GSX2 Gene

protein-coding   GIFtS: 45
GCID: GC04P054966

GS Homeobox 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GS Homeobox 21 2
Homeobox Protein GSH-22 3
GSH22 3

External Ids:    HGNC: 249591   Entrez Gene: 1708252   Ensembl: ENSG000001806137   UniProtKB: Q9BZM33   

Export aliases for GSX2 gene to outside databases

Previous GC identifers: GC04P054661 GC04P050913


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GSX2 Gene:
GSX2 (GS homeobox 2) is a protein-coding gene. Diseases associated with GSX2 include myeloid leukemia, and cerebritis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: GSX2_HUMAN, Q9BZM3
Function: Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_022853.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSX2 gene promoter:
         AREB6   PPAR-gamma1   POU2F1   POU2F1a   Nkx2-2   AP-2beta   ZID   PPAR-gamma2   AP-2gamma   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSX2 promoter sequence
   Search Chromatin IP Primers for GSX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

GSX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSX2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P054966:  view genomic region     (about GC identifiers)

Start:
54,965,690 bp from pter      End:
54,968,672 bp from pter
Size:
2,983 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GSX2_HUMAN, Q9BZM3 (See protein sequence)
Recommended Name: GS homeobox 2  
Size: 304 amino acids; 32031 Da

Explore the universe of human proteins at neXtProt for GSX2: NX_Q9BZM3

Explore proteomics data for GSX2 at MOPED


See GSX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_573574.1  
ENSEMBL proteins: 
 ENSP00000319118   ENSP00000422213  

GSX2 Human Recombinant Protein Products:

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Browse recombinant and purified proteins available from Enzo Life Sciences
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OriGene Protein Over-expression Lysate for GSX2
OriGene Custom MassSpec
OriGene Custom Protein Services for GSX2
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Novus Biologicals GSX2 Protein
Novus Biologicals GSX2 Lysate
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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for GSX2

GSX2 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of GSX2
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OriGene Custom Antibody Services for GSX2
Novus Biologicals GSX2 Antibody
Search for Antibodies for GSX2 at Abcam
Cloud-Clone Corp. Antibodies for GSX2
Search ThermoFisher Antibodies for GSX2
LSBio Antibodies in human, mouse, rat for GSX2

GSX2 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for GSX2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for GSX2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for GSX2
Cloud-Clone Corp. CLIAs for GSX2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9BZM3

ProtoNet protein and cluster: Q9BZM3

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: GSX2_HUMAN, Q9BZM3
Similarity: Belongs to the Antp homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


GSX2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GSX2_HUMAN, Q9BZM3
Function: Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
GSX2 for ontologies           About GeneDecksing


Phenotypes:
     10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gsx2):
 behavior/neurological  cellular  craniofacial  endocrine/exocrine gland  homeostasis/metabolism 
 mortality/aging  nervous system  normal  respiratory system  taste/olfaction 

GSX2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for GSX2: Gsx2tm1Ssp Gsx2tm2.2Kc

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSX2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSX2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSX2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSX2

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat GSX2 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate GSX2
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for GSX2
Predesigned siRNA for gene silencing in human, mouse, rat GSX2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for GSX2

Clone
Products:
     
OriGene clones in human, mouse for GSX2 (see all 5)
OriGene ORF clones in mouse, rat for GSX2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GSX2 (NM_133267)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSX2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for GSX2
Browse ESI BIO Cell Lines and PureStem Progenitors for GSX2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSX2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GSX2_HUMAN, Q9BZM3: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
chloroplast2
cytosol1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

GSX2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GSX2
Interactions:

    Search GeneGlobe Interaction Network for GSX2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for GSX2 (Q9BZM33 ENSP000003191184) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
NKX2-1P436993, ENSP000003468794I2D: score=1 STRING: ENSP00000346879
NKX2-4ENSP000003451474STRING: ENSP00000345147
About this table

Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007389pattern specification process ----
GO:0007417central nervous system development ----

GSX2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for GSX2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GSX2 gene: 
NM_133267.2  

Unigene Cluster for GSX2:

GS homeobox 2
Hs.371899  [show with all ESTs]
Unigene Representative Sequence: AB028838
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000507839 ENST00000326902(uc010igp.1) ENST00000503800 ENST00000548609

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat GSX2 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate GSX2
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for GSX2
Predesigned siRNA for gene silencing in human, mouse, rat GSX2
Clone
Products:
     
OriGene clones in human, mouse for GSX2 (see all 5)
OriGene ORF clones in mouse, rat for GSX2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GSX2 (NM_133267)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSX2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for GSX2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSX2
  QuantiTect SYBR Green Assays in human, mouse, rat GSX2
  QuantiFast Probe-based Assays in human, mouse, rat GSX2

Additional mRNA sequence: 

AB028838.1 BC075089.2 BC075090.2 EU596451.1 

2 DOTS entries:

DT.109238  DT.40295422 

36 AceView cDNA sequences (see top 24):

AA485025 AI360912 BX113485 AI357521 CB054287 NM_133267 AI678083 AI422187 
AA485095 AI356125 AB028838 BC075090 CB054288 BE551998 BX096763 AI937017 
BF508282 AW204644 AA485198 AI971447 AA744807 BC075089 AW779160 AA814828 
AW589813 AW663633 AA485086 AI198063 AI797226 AI934486 AA485142 AA262283 
AA485096 AW967999 AA262824 BE855834 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GSX2 expression in normal human tissues (normalized intensities)      GSX2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACCTGTCTC
GSX2 Expression
About this image


GSX2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Brain (Nervous System)    fully expand to see all 16 entries
         Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
         Thalamus
         Septum   
 
 Neural Tube (Nervous System)    fully expand to see all 6 entries
         Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
         Telencephalon
         Lateral Ganglionic Eminence progenitors
GSX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GSX2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.371899
    Custom PCR Arrays for GSX2
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for GSX2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSX2
QuantiTect SYBR Green Assays in human, mouse, rat GSX2
QuantiFast Probe-based Assays in human, mouse, rat GSX2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSX2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for GSX2 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gsx21 , 5 GS homeobox 21, 5 85.09(n)1
89.14(a)1
  5 (39.55 cM)5
148431  NM_133256.21  NP_573555.11 
 750754645 
chicken
(Gallus gallus)
Aves GSX21 GS homeobox 2 77.63(n)
81.58(a)
  429994  XM_003641207.2  XP_003641255.1 
lizard
(Anolis carolinensis)
Reptilia GSX26
GS homeobox 2
63(a)
1 ↔ 1
5(103977761-103985160)
tropical clawed frog
(Xenopus tropicalis)
Amphibia gsx21 GS homeobox 2 71.23(n)
74.27(a)
  549922  NM_001017168.2  NP_001017168.1 
zebrafish
(Danio rerio)
Actinopterygii gsx21 GS homeobox 2 69.71(n)
73.86(a)
  561076  NM_001025512.2  NP_001020683.1 
fruit fly
(Drosophila melanogaster)
Insecta ind6
intermediate neuroblasts defective
31(a)
1 → many
3L(15035894-15037024)


ENSEMBL Gene Tree for GSX2 (if available)
TreeFam Gene Tree for GSX2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for GSX2 gene
GSX12  HOXA32  MEOX12  EVX22  HOXA12  HOXB12  HOXB32  HOXD12  
HOXA22  EVX12  HOXB22  MEOX22  PDX12  HOXD32  
6 SIMAP similar genes for GSX2 using alignment to 3 protein entries:     GSX2_HUMAN (see all proteins):
HOXC13    HOX B6    HOXA4    HOXB1    NKX2-5    GSX1

GSX2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GSX2 (see all 85)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1459681931,2
--50911227(+) GCTGGC/GAACAT 1 -- us2k10--------
rs1825245721,2
C--50911240(+) TGACTC/GAAACC 1 -- us2k10--------
rs42938421,2
C,F,A,H--50911291(+) CAGAGT/GAGGAA 1 -- us2k1 trp319Minor allele frequency- G:0.44NS EA NA CSA WA 2344
rs1393784021,2
--50911330(+) TATCTA/GTATCT 1 -- us2k10--------
rs45651401,2
C,F,A--50911363(+) TTGCAT/AAGTGA 1 -- us2k17Minor allele frequency- A:0.39NA CSA WA EA 366
rs1875222281,2
--50911537(+) AAGGGC/TGGGCT 1 -- us2k10--------
rs44981891,2
C,F--50911557(+) CTGAGT/CGTCTG 1 -- us2k17Minor allele frequency- C:0.39NA CSA WA EA 366
rs1500251091,2
--50911719(+) TAATTG/TAATTC 1 -- us2k10--------
rs1921476041,2
--50911802(+) CTGGGA/CTCCCC 1 -- us2k10--------
rs1454089161,2
--50911907(+) AGAGCC/TGTGCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for GSX2 (54965690 - 54968672 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for GSX2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv879018CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing GSX2
DNA2.0 Custom Variant and Variant Library Synthesis for GSX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases for GSX2:    About MalaCards
myeloid leukemia    cerebritis    neuronitis    leukemia


GSX2 for disorders           About GeneDecksing


Export disorders for GSX2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GSX2 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with GSX2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13). (PubMed id 11861295)1, 3, 9 Cools J....Marynen P. (Blood 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Heterozygous truncating mutation in the human homeobox gene GSH2 has no discernable phenotypic effect. (PubMed id 12205114)1, 3 Dauwerse J.G....Peters D.J. (J. Med. Genet. 2002)
  4. The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors. (PubMed id 22242181)1 MAcndez-GA^mez H.R. and Vicario-AbejA^n C. (PLoS ONE 2012)
  5. MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. (PubMed id 21368052)1 Shibata M....Aizawa S. (J. Neurosci. 2011)
  6. Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates. (PubMed id 19709628)1 Waclaw R.R....Campbell K. (Neuron 2009)
  7. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
  8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 170825 HGNC: 24959 AceView: GSH-2 Ensembl:ENSG00000180613 euGenes: HUgn170825
ECgene: GSX2 H-InvDB: GSX2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GSX2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GSX2 gene:
Search GeneIP for patents involving GSX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse Small Molecules at EMD Millipore
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 Block miRNA regulation of human, mouse, rat GSX2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GSX2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSX2 Predesigned siRNA for gene silencing in human, mouse, rat GSX2
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 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSX2  Search GeneGlobe Interaction Network for GSX2
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 GenScript Custom Purified and Recombinant Proteins Services for GSX2 GenScript cDNA clones with any tag delivered in your preferred vector for GSX2
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 Search Tocris compounds for GSX2
 Browse Sino Biological Proteins
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 Protein Production Services
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 GSX2 antibodies
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 GSX2 lysates
 Search for Antibodies for GSX2 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for GSX2
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for GSX2
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 Browse ESI BIO Cell Lines and PureStem Progenitors for GSX2
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSX2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for GSX2
 SwitchGear Promoter luciferase reporter plasmids for GSX2
 Search ThermoFisher Antibodies for GSX2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSX2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSX2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSX2
 LSBio Antibodies in human, mouse, rat for GSX2
Customized transgenic rodents for:
 Humanization
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 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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