GSX1 Gene
protein-coding GIFtS: 41
GCID: GC13P028366
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GS homeobox 1
(Previous symbol: GSH1)
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Aliases
for GSX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GS Homeobox 11 2 | | GSH11 2 3 | | Gsh-11 2 | | Homeobox Protein GSH-12 3 | | Genomic Screened Homeo Box 12 | | GS Homeo Box Protein 12 |
Export aliases for GSX1 gene to outside databasesPrevious GC identifers: GC13P027265 GC13P009187 |
Summaries
for GSX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GSX1_HUMAN, Q9H4S2Function: Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates thetranscription of the GHRH gene. Plays an important role in pituitary development
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Genomic Views
for GSX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GSX1 gene promoter:
Egr-3 HFH-3 Pbx1a NRSF form 1 Nkx2-5 NRSF form 2 Arnt FOXI1 PPAR-alpha Nkx6-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GSX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.2 Ensembl cytogenetic band: 13q12.2 HGNC cytogenetic band: 13q12.2GSX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P028366: view genomic region
(about GC identifiers)
Start:
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28,366,780 bp from pter |
End:
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28,368,905 bp from pter |
Size:
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2,126 bases |
Orientation:
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plus strand |
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Proteins
for GSX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GSX1_HUMAN, Q9H4S2 (See
protein sequence)Recommended Name: GS homeobox 1 Size: 264 amino acids; 27883 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q9UD62Explore the universe of human proteins at neXtProt for GSX1: NX_Q9H4S2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4S2
GSX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663632.1
ENSEMBL proteins: ENSP00000304331
Human Recombinant Protein Products for GSX1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
GSX1 for ontologies About GeneDecksing
GSX1 Antibody Products:
Assay Products for GSX1: |
Protein
Domains /
Families
for GSX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GSX1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H4S2ProtoNet protein and cluster: Q9H4S2 1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature
UniProtKB/Swiss-Prot: GSX1_HUMAN, Q9H4S2Similarity: Belongs to the Antp homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for GSX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: GSX1_HUMAN, Q9H4S2Function: Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates thetranscription of the GHRH gene. Plays an important role in pituitary development Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IDA | 11731616 |
GSX1 for ontologies About GeneDecksing
Phenotypes:
11 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gsx1):
GSX1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Gsx1tm1Ssp for GSX1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSX1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GSX1 (NM_145657) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSX1 |
|
Pathways & Interactions
for GSX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSX1
1 Interacting protein for GSX1 (Q9H4S23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0021527 | spinal cord association neuron differentiation |
IEA | -- | | GO:0021854 | hypothalamus development |
IEA | -- | | GO:0021984 | adenohypophysis development |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IDA | 11731616 |
GSX1 for ontologies About GeneDecksing
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Drugs & Compounds
for GSX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GSX1 for compounds About GeneDecksing
 Browse Tocris compounds for GSX1
1 Novoseek chemical compound relationship for GSX1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gamma-glutamylcysteine |
78.6 |
4 |
14530437 (1), 11402187 (1), 17853356 (1), 17253982 (1) |
Search CenterWatch for drugs/clinical trials and news about GSX1
|
Transcripts
for GSX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GSX1 gene: NM_145657.1 Unigene Cluster for GSX1: GS homeobox 1 Hs.351785 Unigene Representative Sequence: NM_1456571 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000302945(uc001urr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSX1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GSX1 (NM_145657) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSX1 |
Additional cDNA sequence: AB044157.1 1 DOTS entry: DT.95187651 2 AceView cDNA sequences: NM_145657 AB044157
GeneLoc Exon Structure
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Expression
for GSX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GSX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCCGTCCT
About this image
See GSX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSX1
SOURCE GeneReport for Unigene cluster: Hs.351785
SABiosciences Custom PCR Arrays for GSX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSX1 |
Orthologs
for GSX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GSX1 gene from 3/15 species (see all 15) About this table
ENSEMBL Gene Tree for GSX1 (if available)
TreeFam Gene Tree for GSX1 (if available) |
Paralogs
for GSX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GSX1 gene
- HOXA72 HOXA12 HOXD12 HOXA22 HOXB32 HOXC62 HOXB52 GSX22
- HOXC52 HOXB42 HOXA52 HOXA42 HOXD32 HOXC82 HOXA62 HOXA32
- HOXD82 HOXB12 HOXB62 HOXB82 HOXD42 HOXB22 HOXB72 PDX12
- HOXC42
1 SIMAP similar gene for GSX1 using alignment to 1 protein entry: GSX1_HUMAN:GSX2
GSX1 for paralogs About GeneDecksing
|
Genomic Variants
for GSX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSX1 |
|
Disorders
/ Diseases
for GSX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GSX1 for disorders About GeneDecksing
7  diseases for GSX1: About MalaCardsfacial paralysis moebius syndrome conduct disorder paralysis
adhd pancreatitis neuronitis
Export disorders for GSX1 gene to outside databases
|
Publications
for GSX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GSX1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with GSX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Homeobox protein Gsh-1-dependent regulation of the rat GHRH gene promoter. (PubMed id 11731616)1, 2, 9 Mutsuga N.... Saito H. (2001)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- Molecular genetic screening of MBS1 locus on chromoso me 13 for microdeletions and exclusion of FGF9, GSH1 and CDX2 as causative gene s in patients with Moebius syndrome. (PubMed id 19460469)1, 9 Uzumcu A....Basaran S. (2009)
- Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1 Anney R.J....Gill M. (2008)
- Identification of homeobox genes expressed in human haemopoietic progenitor cells. (PubMed id 7518789)2 Moretti P....D'Andrea R. (1994)
- Novel insight into the regulation of GSH biosynthesis in higher plants. (PubMed id 17853356)9 Rausch T....Wachter A. (2007)
- The Arabidopsis Ethylene-Insensitive 2 gene is required for lead resistance. (PubMed id 19153049)9 Cao S....Ma X. (2009)
- Transcriptional profiling of the Candida albicans Ssk1p receiver domain point mutants and their virulence. (PubMed id 18616606)9 Menon V....Chauhan N. (2008)
- ParaHox genes in pancreatic cell cultures: effects on the insulin promoter regulation. (PubMed id 18274620)9 Rosanas-Urgell A....Marfany G. (2008)
- Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide. (PubMed id 17253982)9 Lopez-Mirabal H.R....Winther J.R. (2007)
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External Searches for GSX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing GSX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GSX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GSX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GSX1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for GSX1 gene:
Search GeneIP for patents involving GSX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GSX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GSX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSX1 | | | OriGene Protein Over-expression Lysate for GSX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GSX1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSX1 |
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| | | | Search Tocris compounds for GSX1 |
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 | | | GSX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for GSX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSX1 |
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