Aliases for GSTT2B Gene
External Ids for GSTT2B Gene
Previous GeneCards Identifiers for GSTT2B Gene
The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
GeneCards Summary for GSTT2B Gene
GSTT2B (Glutathione S-Transferase Theta 2B (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with GSTT2B include Deafness, Autosomal Recessive 12. Among its related pathways are Platinum drug resistance and Glutathione metabolism. GO annotations related to this gene include transferase activity and glutathione transferase activity. An important paralog of this gene is GSTT2.
UniProtKB/Swiss-Prot for GSTT2B Gene
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.