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Aliases for GSTT2B Gene

Aliases for GSTT2B Gene

  • Glutathione S-Transferase Theta 2B (Gene/Pseudogene) 2 3 5
  • Glutathione S-Transferase Theta-2 3 4
  • GST Class-Theta-2 3 4
  • Glutathione S-Transferase Theta 2 3
  • EC 2.5.1.18 4
  • GSTT2P 3
  • GSTT2 4

External Ids for GSTT2B Gene

Previous GeneCards Identifiers for GSTT2B Gene

  • GC22M022631
  • GC22M024299

Summaries for GSTT2B Gene

Entrez Gene Summary for GSTT2B Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT2B Gene

GSTT2B (Glutathione S-Transferase Theta 2B (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Glutathione metabolism. GO annotations related to this gene include transferase activity and glutathione transferase activity. An important paralog of this gene is GSTT2.

UniProtKB/Swiss-Prot for GSTT2B Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT2B Gene

Genomics for GSTT2B Gene

Regulatory Elements for GSTT2B Gene

Enhancers for GSTT2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSTT2B on UCSC Golden Path with GeneCards custom track

Promoters for GSTT2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSTT2B on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTT2B Gene

Chromosome:
22
Start:
23,957,414 bp from pter
End:
23,961,234 bp from pter
Size:
3,821 bases
Orientation:
Minus strand

Genomic View for GSTT2B Gene

Genes around GSTT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT2B Gene

Proteins for GSTT2B Gene

  • Protein details for GSTT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG30-GSTT2_HUMAN
    Recommended name:
    Glutathione S-transferase theta-2B
    Protein Accession:
    P0CG30
    Secondary Accessions:
    • O60665
    • P30712
    • Q6IPV7
    • Q9HD76

    Protein attributes for GSTT2B Gene

    Size:
    244 amino acids
    Molecular mass:
    27507 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT2B Gene

neXtProt entry for GSTT2B Gene

Proteomics data for GSTT2B Gene at MOPED

Post-translational modifications for GSTT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSTT2B Gene

Domains & Families for GSTT2B Gene

Gene Families for GSTT2B Gene

Protein Domains for GSTT2B Gene

Suggested Antigen Peptide Sequences for GSTT2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG30

UniProtKB/Swiss-Prot:

GSTT2_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Theta family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT2B: view

Function for GSTT2B Gene

Molecular function for GSTT2B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Enzyme Numbers (IUBMB) for GSTT2B Gene

Gene Ontology (GO) - Molecular Function for GSTT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with GSTT2B: view

Phenotypes for GSTT2B Gene

MGI mutant phenotypes for GSTT2B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with GSTT2B: view

Animal Model Products

CRISPR Products

miRNA for GSTT2B Gene

miRTarBase miRNAs that target GSTT2B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTT2B Gene

Localization for GSTT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT2B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTT2B Gene COMPARTMENTS Subcellular localization image for GSTT2B gene
Compartment Confidence
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for GSTT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GSTT2B: view

Pathways & Interactions for GSTT2B Gene

genes like me logo Genes that share pathways with GSTT2B: view

Pathways by source for GSTT2B Gene

Interacting Proteins for GSTT2B Gene

Gene Ontology (GO) - Biological Process for GSTT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GSTT2B: view

No data available for SIGNOR curated interactions for GSTT2B Gene

Drugs & Compounds for GSTT2B Gene

(2) Drugs for GSTT2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra 0
Trichloroethylene Pharma 5

(39) Additional Compounds for GSTT2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTT2B: view

Transcripts for GSTT2B Gene

mRNA/cDNA for GSTT2B Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSTT2B Gene

Glutathione S-transferase theta 2B (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT2B Gene

No ASD Table

Relevant External Links for GSTT2B Gene

GeneLoc Exon Structure for
GSTT2B
ECgene alternative splicing isoforms for
GSTT2B

Expression for GSTT2B Gene

mRNA expression in normal human tissues for GSTT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTT2B Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for GSTT2B Gene

This gene is overexpressed in Fetal heart (19.4), Ovary (18.6), Fetal ovary (7.0), and Fetal testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTT2B Gene



SOURCE GeneReport for Unigene cluster for GSTT2B Gene Hs.656498

mRNA Expression by UniProt/SwissProt for GSTT2B Gene

P0CG30-GSTT2_HUMAN
Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.
genes like me logo Genes that share expression patterns with GSTT2B: view

Primer Products

No data available for Protein tissue co-expression partners for GSTT2B Gene

Orthologs for GSTT2B Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTT2B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100686488 35
  • 81.56 (n)
  • 75 (a)
-- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gstt2 35
  • 79.37 (n)
  • 77.87 (a)
Gstt2 16
Gstt2 36
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GSTT2 35
  • 98.91 (n)
  • 98.77 (a)
GSTT2B 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gstt2 35
  • 80.46 (n)
  • 78.28 (a)
cow
(Bos Taurus)
Mammalia GSTT3 36
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves GSTT1 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstt1b 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1681 36
  • 30 (a)
ManyToMany
CG1702 36
  • 27 (a)
ManyToMany
CG30000 36
  • 30 (a)
ManyToMany
CG30005 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for GSTT2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTT2B Gene

ENSEMBL:
Gene Tree for GSTT2B (if available)
TreeFam:
Gene Tree for GSTT2B (if available)

Paralogs for GSTT2B Gene

Paralogs for GSTT2B Gene

(3) SIMAP similar genes for GSTT2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GSTT2B: view

Variants for GSTT2B Gene

Sequence variations from dbSNP and Humsavar for GSTT2B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1622002 - 23,958,393(-) GCCAT(A/G)GACCA reference, missense
rs2227965 -- 23,958,447(-) GGGCC(A/C)CTCAT reference, synonymous-codon
rs2267048 -- 23,960,711(-) GACCT(C/T)GGGAA intron-variant
rs140185 -- 23,961,757(-) TCCTT(A/G)ACCCC upstream-variant-2KB
rs140187 -- 23,960,696(-) GACAT(A/G)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTT2B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
nsv436348 CNV Deletion 17901297
esv999560 CNV Deletion 20482838
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
esv2593346 CNV Deletion 19546169
nsv512650 CNV Loss 21212237
nsv829105 CNV Loss 20364138
esv2724066 CNV Deletion 23290073
nsv9878 CNV Gain+Loss 18304495
esv2667916 CNV Deletion 23128226
dgv35n47 CNV Loss 21111241
esv6716 CNV Loss 19470904
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
esv1449016 OTHER Inversion 17803354
esv2656467 CNV Deletion 23128226

Variation tolerance for GSTT2B Gene

Gene Damage Index Score: 4.53; 64.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTT2B Gene

Human Gene Mutation Database (HGMD)
GSTT2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT2B Gene

Disorders for GSTT2B Gene

Relevant External Links for GSTT2B

Human Genome Epidemiology (HuGE) Navigator
GSTT2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTT2B

No disorders were found for GSTT2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTT2B Gene

Publications for GSTT2B Gene

  1. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. (PMID: 22676722) Bustamante M. … Kogevinas M. (BJOG 2012) 3
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3

Products for GSTT2B Gene

Sources for GSTT2B Gene

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