Aliases for GSTT2 Gene
External Ids for GSTT2 Gene
Previous GeneCards Identifiers for GSTT2 Gene
The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
GeneCards Summary for GSTT2 Gene
GSTT2 (Glutathione S-Transferase Theta 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with GSTT2 include Colon Adenoma and Barrett's Adenocarcinoma. Among its related pathways are Glutathione metabolism and Platinum drug resistance. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTT2B.
UniProtKB/Swiss-Prot for GSTT2 Gene
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.