Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTT2 Gene

protein-coding GIFtS: 61
GCID: GC22P024322

glutathione S-transferase theta 2

Explore 11 diseases affiliated with
GSTT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutathione S-Transferase Theta 2¹ ²
GST Class-Theta-2² ³
GSTT2B²
Glutathione S-Transferase Theta-2²
Glutathione S-Transferase Theta-2B²
EC 2.5.1.18³

External Ids:	HGNC: 4642¹	Entrez Gene: 2953²	Ensembl: ENSG00000099984⁷	OMIM: 600437⁵	UniProtKB: P0CG29³

Export aliases for GSTT2 gene to outside databases

Previous GC identifers: GC22P021018 GC22P022646 GC22P022652 GC22P007270

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTT2:

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation

of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five

main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence

identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar

structure, being composed of five exons with identical exon/intron boundaries. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Has a sulfatase activity

summary for GSTT2:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTT2 gene promoter:
GR p53 AP-1 SREBP-1c GR-beta ATF-2 SREBP-1a c-Jun GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTT2 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

GSTT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTT2 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P024322: view genomic region (about GC identifiers)

Start:	24,322,314 bp from pter	End:	24,326,106 bp from pter
Size:	3,793 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29 (See protein sequence)

Recommended Name: Glutathione S-transferase theta-2

Size: 244 amino acids; 27506 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

Secondary accessions: O60665 P30712 Q6IPV7 Q9HD76

Explore the universe of human proteins at neXtProt for GSTT2: NX_P0CG29

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P0CG29

GSTT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000845.1

ENSEMBL proteins:

ENSP00000215780 ENSP00000385765

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GSTT2 OriGene Protein Over-expression Lysate: GSTT2 OriGene Custom Protein Services for GSTT2
	GenScript Custom Purified and Recombinant Proteins Services for GSTT2
	Novus Biologicals GSTT2 Proteins Novus Biologicals GSTT2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for GSTT2
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

GSTT2 for ontologies About GeneDecksing

GSTT2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 10): GSTT2 OriGene Custom Antibody Services for GSTT2
	GenScript Custom Superior Antibodies Services for GSTT2
	Novus Biologicals GSTT2 Antibodies
	Search for Antibodies for GSTT2 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for GSTT2

Assay Products for GSTT2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GSTT2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTT2 for domains About GeneDecksing

5 InterPro domains/families:

IPR012336 Thioredoxin-like_fold

IPR004046 GST_C

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR004045 Glutathione_S-Trfase_N

IPR010987 Glutathione-S-Trfase_C-like

Graphical View of Domain Structure for InterPro Entry P0CG29

ProtoNet protein and cluster: P0CG29

UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29

Similarity: Belongs to the GST superfamily. Theta family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Has a sulfatase activity

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Genatlas biochemistry entry for GSTT2:

glutathione-S-transferase 2,theta class,separated by 50kb from GSTT1,tighlty linked to DDT,in head to head

disposition,likely a pseudogene with a splice site abnormality and a premature translation stop signal

Enzyme Number (IUBMB): EC 2.5.1.18¹

miRNA Products:		OriGene 3'-UTR Clone: GSTT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTT2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GSTT2
		SwitchGear 3'UTR luciferase reporter plasmid: GSTT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSTT2 (see all 7) OriGene shRNA RFP: GSTT2 OriGene siRNA: GSTT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTT2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GSTT2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSTT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSTT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GSTT2 (NM_000854)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GSTT2
		Search LifeMap BioReagents cell lines for GSTT2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IEA	--

GSTT2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GSTT2:

Increased cell death HMECs cel

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gstt2):

normal

GSTT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

	Glutathione metabolism	1.00			Glutathione metabolism	0.44
	Glutathione metabolism	0.70

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Oxidative Stress

Oxidative Stress

1.00

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GSTT2

Glutathione metabolism

3 BioSystems Pathways for GSTT2

	Glutathione metabolism
	Oxidative Stress
	metapathway biotransformation

3 Kegg Pathways (Kegg details for GSTT2):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

GSTT2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GSTT2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for GSTT2 (P0CG29³ ENSP00000215780⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSTT2B	P0CG30³, ENSP00000290765⁴	I2D: score=1 STRING: ENSP00000290765

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSTT2 for compounds About GeneDecksing

EMD Millipore small molecules for GSTT2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTT2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

10/12 HMDB Compounds for GSTT2 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

1 DrugBank Compound for GSTT2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
S-Hexylglutathione	--	--	target	--	10592235

1 Novoseek chemical compound relationship for GSTT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	87.8	3	15746163 (1), 17982697 (1), 18664505 (1)

Search CenterWatch for drugs/clinical trials and news about GSTT2 / GST2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTT2 gene:

NM_000854.3

Unigene Cluster for GSTT2:

Glutathione S-transferase theta 2

Hs.654462 [show with all ESTs]

Unigene Representative Sequence: CD013992

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000215780(uc002zzb.4 uc002zzc.4) ENST00000402588

miRNA Products:		OriGene 3'-UTR Clone: GSTT2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTT2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GSTT2
		SwitchGear 3'UTR luciferase reporter plasmid: GSTT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSTT2 (see all 7) OriGene shRNA RFP: GSTT2 OriGene siRNA: GSTT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTT2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSTT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSTT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GSTT2 (NM_000854)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSTT2 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat GSTT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTT2

Additional cDNA sequence:

AK312043.1 BC002415.1 BC146929.1 BC146940.1 BC146943.1 CR456374.1 CR456500.1 CR456929.1

L38503.1

10 DOTS entries:

DT.315274 DT.100757482 DT.120669389 DT.100738109 DT.95264485 DT.315273 DT.92420542 DT.101954193

DT.101983385 DT.101983387

24/94 AceView cDNA sequences (see all 94):

BQ011989 CR590685 CD014128 BQ012116 BM976631 N71130 CR612277 BQ613805

BU584249 CR601749 CR456374 BP347591 BQ267814 AA490208 BF969736 BC002415

CD013993 BQ012298 CD013991 BX389184 BV169468 BX388289 L38503 AA009800

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

GSTT2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GSTT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTT2

SOURCE GeneReport for Unigene cluster: Hs.654462

UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29

Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells,

alveolar macrophages and alveolar type II cells

SABiosciences Custom PCR Arrays for GSTT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSTT2 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat GSTT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSTT2 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	E1BUB6_CHICK⁶ GSTT1_CHICK⁶	Glutathione S-transferase theta-1	47(a) 43(a)	many ↔ many many ↔ many	15(8350536-8356364) 15(8360872-8370441)
lizard (Anolis carolinensis)	Reptilia	-- --	--	51(a) 45(a)	many ↔ many many ↔ many	GL344539.1(13835-19538) GL344539.1(28836-32313)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24816²	Xenopus laevis transcribed sequence with weak similarity more	74.56(n)		48050565
zebrafish (Danio rerio)	Actinopterygii	gstt1b⁶ gstt1a⁶ (see all 3)	glutathione S-transferase theta 1a (see all 3)	46(a) 45(a) (see all 3)	many ↔ many many ↔ many (see all 3)	21(13916165-13923602) 8(31635153-31639308)
fruit fly (Drosophila melanogaster)	Insecta	gfzf⁶ CG30000⁶ (see all 30)	--	5(a) 30(a) (see all 30)	possible ortholog many ↔ many (see all 30)	3R(2971596-2976661) 2R(5493495-5494689)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATGSTT1⁶ GSTT3⁶ (see all 3)	glutathione S-transferase THETA 3 (see all 3)	33(a) 13(a) (see all 3)	many ↔ many many ↔ many (see all 3)	5(16492320-16493994) 5(16494426-16497068)
rice (Oryza sativa)	Liliopsida	--	glutathione S-transferase, N-terminal domain conta...	32(a)	1 → many	11(21839554-21843963)

ENSEMBL Gene Tree for GSTT2 (if available)
TreeFam Gene Tree for GSTT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSTT2 gene

GSTT2B¹ ² GSTT1²

4 SIMAP similar genes for GSTT2 using alignment to 6 protein entries: GST2_HUMAN (see all proteins):

GSTT2B GSTT1 GSTT4 Em

GSTT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190188685^1,2		--	24324050(+)	`CCCCCC/GACCTC`	1	--	int¹		0	--	--	--	--
rs140188^1,2	F,A,H,	--	24324052(+)	`CCCCAG/CCTCTC`	1	--	int¹		4		NS EA	418
rs200741142^1,2		--	24324062(+)	`ATCTT-/CCAGCC`	1	--	int¹		0	--	--	--	--
rs182781628^1,2		--	24324311(+)	`TGGCTA/GCAGAG`	1	--	int¹		0	--	--	--	--
rs199522839^1,2		--	24324883(+)	`CTGACC/TTGCAG`	2	L	syn¹		0	--	--	--	--
rs200925305^1,2	F	--	24325006(+)	`ATCAGA/GGAGTA`	1	--	int¹		1		EU	701
rs201723657^1,2	F	--	24325024(+)	`GTAGGT/CCGGGG`	1	--	int¹		1		EU	963
rs149686121^1,2	C,F,	--	24325047(+)	`CCACTG/CTCTGC`	1	--	int¹		1		EU	1039
rs78284383^1,2	C,F,	--	24325062(+)	`ATCAGG/ATGTTG`	2	/M /V	mis¹		1		EU	1235
rs60718122^1,2	C,F,	--	24325127(+)	`GCCATG/AGACCA`	2	/I /M	mis¹		3		NA EU	3901

HapMap Linkage Disequilibrium report for GSTT2 (24322314 - 24326106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for GSTT2
15 CNVs: 67856 103140 22918 36014 73792 73785 3238 36013 0548 32452 36012 73786 73794 38793 61995
Human Gene Mutation Database (HGMD): GSTT2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSTT2

DNA2.0 Custom Variant and Variant Library Synthesis for GSTT2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GSTT2 for disorders           About GeneDecksing

OMIM gene information: 600437    OMIM disorders: --

11 diseases for GSTT2:    About MalaCards

malignant pleural mesothelioma barrett's adenocarcinoma gastric cancer colorectal cancer

lung cancer adenocarcinoma prostate cancer adenoma

prostatitis schizophrenia alcoholism

Genetic Association Database (GAD): GSTT2
Human Genome Epidemiology (HuGE) Navigator: GSTT2 (19 documents)

Export disorders for GSTT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GSTT2 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with GSTT2)

Utopia: connect your pdf to the dynamic
world of online information

Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PubMed id 9729470)^{1, 3, 9} Coggan M....Board P. (1998)
Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PubMed id 7789971)^{1, 3, 9} Tan K.L.... Board P.G. (1995)
Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (PubMed id 15654505)^{1, 4} Liu Y....Tsugane S. (2005)
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. (PubMed id 16006997)^{1, 4} Landi S....Canzian F. (2005)
Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. (PubMed id 10975610)^{1, 2} Sprenger R.... Brinkmann U. (2000)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. (PubMed id 8761485)^{1, 2} Mainwaring G.W.... Green T. (1996)
Characterization of a human class-theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. (PubMed id 1417752)^{1, 2} Hussey A.J. and Hayes J.D. (1992)
GSTT2 promoter polymorphisms and colorectal cancer risk. (PubMed id 17250773)^{1, 9} Jang S.G....Park J.G. (2007)
Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. (PubMed id 18449862)^{1, 9} Matsuzawa D....Iyo M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2953	HGNC: 4642	AceView: GSTT2	Ensembl:ENSG00000099984	euGenes: HUgn2953
ECgene: GSTT2	Kegg: 2953	H-InvDB: GSTT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GSTT2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GSTT2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GSTT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GSTT2 gene:
Search GeneIP for patents involving GSTT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore small molecules (inhibitor) for GSTT2
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for GSTT2		OriGene shRNA RFP for GSTT2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSTT2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSTT2
	OriGene Protein Over-expression Lysate for GSTT2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GSTT2		OriGene 3'-UTR Clone for GSTT2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSTT2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSTT2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for GSTT2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GSTT2		OriGene Custom Protein Services for GSTT2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSTT2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSTT2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTT2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTT2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTT2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTT2

	GenScript Custom Purified and Recombinant Proteins Services for GSTT2		GenScript cDNA clones with any tag delivered in your preferred vector for GSTT2
	GenScript Custom Assay Services for GSTT2		GenScript Custom Superior Antibodies Services for GSTT2
	GenScript Custom overexpressing Cell Line Services for GSTT2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GSTT2 promoter
	Search Chromatin IP Primers for GSTT2
	RT² qPCR Primer Assay in human, mouse / rat GSTT2
	GNC Network for GSTT2
	SABiosciences Custom PCR Arrays for GSTT2

Tocris compounds for GSTT2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GSTT2 antibodies
	GSTT2 proteins
	GSTT2 lysates

	Search for Antibodies for GSTT2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for GSTT2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for GSTT2

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GSTT2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT2

	SwitchGear 3'UTR luciferase reporter plasmids for GSTT2
	SwitchGear Promoter luciferase reporter plasmids for GSTT2

Search ThermoFisher Antibodies for GSTT2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GSTT2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GSTT2 Gene

glutathione S-transferase theta 2

Aliases
for GSTT2 gene

Summaries
for GSTT2 gene

Genomic Views
for GSTT2 gene

Proteins
for GSTT2 gene

Protein Domains /
Families
for GSTT2 gene

Function
for GSTT2 gene

Pathways & Interactions
for GSTT2 gene

Drugs & Compounds
for GSTT2 gene

Transcripts
for GSTT2 gene

Expression
for GSTT2 gene

Orthologs
for GSTT2 gene

Paralogs
for GSTT2 gene

Genomic Variants
for GSTT2 gene

Disorders / Diseases
for GSTT2 gene

Publications
for GSTT2 gene

External Searches for GSTT2 gene

Genome Databases showing GSTT2 gene

Other Databases showing GSTT2 gene

Specialized Databases showing GSTT2 gene

Intellectual Property
for GSTT2 gene

Products
for GSTT2 gene

View Random Gene

Advanced Search

Export list of displayed genes

GSTT2 Gene

glutathione S-transferase theta 2

Aliasesfor GSTT2 gene

Summariesfor GSTT2 gene

Genomic Viewsfor GSTT2 gene

Proteinsfor GSTT2 gene

Protein Domains /Familiesfor GSTT2 gene

Functionfor GSTT2 gene

Pathways & Interactionsfor GSTT2 gene

Drugs & Compoundsfor GSTT2 gene

Transcriptsfor GSTT2 gene

Expression for GSTT2 gene

Orthologsfor GSTT2 gene

Paralogsfor GSTT2 gene

Genomic Variantsfor GSTT2 gene

Disorders / Diseasesfor GSTT2 gene

Publicationsfor GSTT2 gene

External Searches for GSTT2 gene

Genome Databases showing GSTT2 gene

Other Databases showing GSTT2 gene

Specialized Databases showing GSTT2 gene

Intellectual Propertyfor GSTT2 gene

Productsfor GSTT2 gene

View Random Gene

Aliases
for GSTT2 gene

Summaries
for GSTT2 gene

Genomic Views
for GSTT2 gene

Proteins
for GSTT2 gene

Protein Domains /
Families
for GSTT2 gene

Function
for GSTT2 gene

Pathways & Interactions
for GSTT2 gene

Drugs & Compounds
for GSTT2 gene

Transcripts
for GSTT2 gene

Expression
for GSTT2 gene

Orthologs
for GSTT2 gene

Paralogs
for GSTT2 gene

Genomic Variants
for GSTT2 gene

Disorders / Diseases
for GSTT2 gene

Publications
for GSTT2 gene

Intellectual Property
for GSTT2 gene

Products
for GSTT2 gene