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Aliases for GSTT2 Gene

Aliases for GSTT2 Gene

  • Glutathione S-Transferase Theta 2 (Gene/Pseudogene) 2 3 5
  • Glutathione S-Transferase Theta 2 2
  • GST Class-Theta-2 4
  • EC 4

External Ids for GSTT2 Gene

Previous GeneCards Identifiers for GSTT2 Gene

  • GC22P021018
  • GC22P022646
  • GC22P022652
  • GC22P024322
  • GC22P007270

Summaries for GSTT2 Gene

Entrez Gene Summary for GSTT2 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT2 Gene

GSTT2 (Glutathione S-Transferase Theta 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with GSTT2 include Colon Adenoma and Barrett's Adenocarcinoma. Among its related pathways are Phase II conjugation and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot for GSTT2 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Gene Wiki entry for GSTT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT2 Gene

Genomics for GSTT2 Gene

Regulatory Elements for GSTT2 Gene

Enhancers for GSTT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSTT2 on UCSC Golden Path with GeneCards custom track

Promoters for GSTT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSTT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTT2 Gene

23,980,028 bp from pter
23,983,915 bp from pter
3,888 bases
Plus strand

Genomic View for GSTT2 Gene

Genes around GSTT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT2 Gene

Proteins for GSTT2 Gene

  • Protein details for GSTT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione S-transferase theta-2
    Protein Accession:
    Secondary Accessions:
    • O60665
    • P30712
    • Q6IPV7
    • Q9HD76

    Protein attributes for GSTT2 Gene

    244 amino acids
    Molecular mass:
    27506 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT2 Gene

neXtProt entry for GSTT2 Gene

Proteomics data for GSTT2 Gene at MOPED

Post-translational modifications for GSTT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT2 Gene

No data available for DME Specific Peptides for GSTT2 Gene

Domains & Families for GSTT2 Gene

Gene Families for GSTT2 Gene

Protein Domains for GSTT2 Gene

Suggested Antigen Peptide Sequences for GSTT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Theta family.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT2: view

Function for GSTT2 Gene

Molecular function for GSTT2 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 2,theta class,separated by 50kb from GSTT1,tighlty linked to DDT,in head to head disposition,likely a pseudogene with a splice site abnormality and a premature translation stop signal
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Enzyme Numbers (IUBMB) for GSTT2 Gene

genes like me logo Genes that share phenotypes with GSTT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTT2

miRNA for GSTT2 Gene

miRTarBase miRNAs that target GSTT2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTT2 Gene

Localization for GSTT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT2 Gene


Subcellular locations from

Jensen Localization Image for GSTT2 Gene COMPARTMENTS Subcellular localization image for GSTT2 gene
Compartment Confidence
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GSTT2: view

Pathways & Interactions for GSTT2 Gene

genes like me logo Genes that share pathways with GSTT2: view

Interacting Proteins for GSTT2 Gene

Selected Interacting proteins: P0CG29-GST2_HUMAN for GSTT2 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GSTT2 Gene


No data available for SIGNOR curated interactions for GSTT2 Gene

Drugs & Compounds for GSTT2 Gene

(2) Drugs for GSTT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra 0
S-Hexylglutathione Experimental Pharma Target 0

(12) Additional Compounds for GSTT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2,3-Dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
  • 2-Hydroxyestrone-1-S-glutathione
  • 2,3-Dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
  • 3,4-Dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
  • AdChr
  • Adrenochrome O-quinone
  • Adrenochrome oxidised
  • N-Methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole
  • N-Methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol
  • Catecholestrogen quinone
genes like me logo Genes that share compounds with GSTT2: view

Transcripts for GSTT2 Gene

mRNA/cDNA for GSTT2 Gene

Unigene Clusters for GSTT2 Gene

Glutathione S-transferase theta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT2 Gene

No ASD Table

Relevant External Links for GSTT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSTT2 Gene

mRNA expression in normal human tissues for GSTT2 Gene

mRNA differential expression in normal tissues according to GTEx for GSTT2 Gene

This gene is overexpressed in Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for GSTT2 Gene

This gene is overexpressed in Skin (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GSTT2 Gene

SOURCE GeneReport for Unigene cluster for GSTT2 Gene Hs.654462

mRNA Expression by UniProt/SwissProt for GSTT2 Gene

Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.
genes like me logo Genes that share expression patterns with GSTT2: view

Protein tissue co-expression partners for GSTT2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GSTT2 Gene

Orthologs for GSTT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100686488 35
  • 81.56 (n)
  • 75 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Gstt2 35
  • 79.37 (n)
  • 77.87 (a)
Gstt2 36
  • 78 (a)
(Pan troglodytes)
Mammalia GSTT2 35
  • 98.91 (n)
  • 98.77 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gstt2 35
  • 80.46 (n)
  • 78.28 (a)
(Bos Taurus)
Mammalia -- 36
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
(Gallus gallus)
Aves -- 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24816 35
(Danio rerio)
Actinopterygii zgc:66350 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1681 36
  • 30 (a)
CG1702 36
  • 27 (a)
CG30000 36
  • 31 (a)
CG30005 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for GSTT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTT2 Gene

Gene Tree for GSTT2 (if available)
Gene Tree for GSTT2 (if available)

Paralogs for GSTT2 Gene

Paralogs for GSTT2 Gene

(3) SIMAP similar genes for GSTT2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GSTT2: view

Variants for GSTT2 Gene

Sequence variations from dbSNP and Humsavar for GSTT2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2719 -- 23,983,759(+) GTGCT(G/T)CTACT nc-transcript-variant
rs140195 -- 23,982,904(+) TGCCC(A/G/T)AGGAG nc-transcript-variant
rs1126752 -- 23,982,630(+) AAGCT(C/T)GGCCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTT2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
nsv436348 CNV Deletion 17901297
esv999560 CNV Deletion 20482838
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
esv2593346 CNV Deletion 19546169
nsv512650 CNV Loss 21212237
nsv829105 CNV Loss 20364138
esv2724066 CNV Deletion 23290073
nsv9878 CNV Gain+Loss 18304495
esv2667916 CNV Deletion 23128226
dgv35n47 CNV Loss 21111241
esv6716 CNV Loss 19470904
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
esv1449016 OTHER Inversion 17803354
esv2656467 CNV Deletion 23128226
nsv511643 CNV Loss 21212237
esv2656800 CNV Deletion 23128226
dgv751n67 CNV Loss 20364138
nsv914614 CNV Loss 21882294
dgv826e199 CNV Deletion 23128226
nsv829109 CNV Loss 20364138
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294
nsv471424 CNV Duplication 19718026
nsv482074 CNV Gain 20164927
dgv4913n71 CNV Gain 21882294

Variation tolerance for GSTT2 Gene

Gene Damage Index Score: 7.80; 83.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTT2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT2 Gene

Disorders for GSTT2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GSTT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon adenoma
  • adenomatous polyp of colon
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GSTT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GSTT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT2 Gene

Publications for GSTT2 Gene

  1. GSTT2 promoter polymorphisms and colorectal cancer risk. (PMID: 17250773) Jang S.G. … Park J.G. (BMC Cancer 2007) 3 23 48 67
  2. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3 23
  3. Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PMID: 7789971) Tan K.L. … Board P.G. (Genomics 1995) 2 3 23
  4. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. (PMID: 18449862) Matsuzawa D. … Iyo M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  5. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. (PMID: 18268125) Wang S. … Perera F.P. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 23

Products for GSTT2 Gene

Sources for GSTT2 Gene