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Aliases for GSTT2 Gene

Aliases for GSTT2 Gene

  • Glutathione S-Transferase Theta 2 (Gene/Pseudogene) 2 3 5
  • Glutathione S-Transferase Theta 2 2
  • GST Class-Theta-2 4
  • EC 2.5.1.18 4

External Ids for GSTT2 Gene

Previous GeneCards Identifiers for GSTT2 Gene

  • GC22P021018
  • GC22P022646
  • GC22P022652
  • GC22P024322
  • GC22P007270

Summaries for GSTT2 Gene

Entrez Gene Summary for GSTT2 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT2 Gene

GSTT2 (Glutathione S-Transferase Theta 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with GSTT2 include Colon Adenoma and Barrett's Adenocarcinoma. Among its related pathways are Phase II conjugation and Glutathione metabolism. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot for GSTT2 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Gene Wiki entry for GSTT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT2 Gene

Genomics for GSTT2 Gene

Regulatory Elements for GSTT2 Gene

Enhancers for GSTT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GSTT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTT2 Gene

Chromosome:
22
Start:
23,980,028 bp from pter
End:
23,983,915 bp from pter
Size:
3,888 bases
Orientation:
Plus strand

Genomic View for GSTT2 Gene

Genes around GSTT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT2 Gene

Proteins for GSTT2 Gene

  • Protein details for GSTT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG29-GST2_HUMAN
    Recommended name:
    Glutathione S-transferase theta-2
    Protein Accession:
    P0CG29
    Secondary Accessions:
    • O60665
    • P30712
    • Q6IPV7
    • Q9HD76

    Protein attributes for GSTT2 Gene

    Size:
    244 amino acids
    Molecular mass:
    27506 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT2 Gene

neXtProt entry for GSTT2 Gene

Post-translational modifications for GSTT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT2 Gene

No data available for DME Specific Peptides for GSTT2 Gene

Domains & Families for GSTT2 Gene

Gene Families for GSTT2 Gene

Protein Domains for GSTT2 Gene

Suggested Antigen Peptide Sequences for GSTT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG29

UniProtKB/Swiss-Prot:

GST2_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Theta family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT2: view

Function for GSTT2 Gene

Molecular function for GSTT2 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 2,theta class,separated by 50kb from GSTT1,tighlty linked to DDT,in head to head disposition,likely a pseudogene with a splice site abnormality and a premature translation stop signal
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Enzyme Numbers (IUBMB) for GSTT2 Gene

Gene Ontology (GO) - Molecular Function for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA --
genes like me logo Genes that share ontologies with GSTT2: view
genes like me logo Genes that share phenotypes with GSTT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTT2

CRISPR Products

miRNA for GSTT2 Gene

miRTarBase miRNAs that target GSTT2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTT2 Gene

Localization for GSTT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTT2 Gene COMPARTMENTS Subcellular localization image for GSTT2 gene
Compartment Confidence
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GSTT2: view

Pathways & Interactions for GSTT2 Gene

genes like me logo Genes that share pathways with GSTT2: view

Interacting Proteins for GSTT2 Gene

Gene Ontology (GO) - Biological Process for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
genes like me logo Genes that share ontologies with GSTT2: view

No data available for SIGNOR curated interactions for GSTT2 Gene

Drugs & Compounds for GSTT2 Gene

(3) Drugs for GSTT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Glutathione Approved Nutra 0
S-Hexylglutathione Experimental Pharma Target 0

(11) Additional Compounds for GSTT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-Dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
  • 2-Hydroxyestrone-1-S-glutathione
2-Hydroxyestrone-4-S-glutathione
  • 2,3-Dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
4-Hydroxyestrone-2-S-glutathione
  • 3,4-Dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Adrenochrome
  • AdChr
  • Adrenochrome O-quinone
  • Adrenochrome oxidised
  • N-Methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole
  • N-Methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol
54-06-8
Estrone-2,3-quinone
  • Catecholestrogen quinone
40551-33-5
genes like me logo Genes that share compounds with GSTT2: view

Transcripts for GSTT2 Gene

mRNA/cDNA for GSTT2 Gene

Unigene Clusters for GSTT2 Gene

Glutathione S-transferase theta 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT2 Gene

No ASD Table

Relevant External Links for GSTT2 Gene

GeneLoc Exon Structure for
GSTT2
ECgene alternative splicing isoforms for
GSTT2

Expression for GSTT2 Gene

mRNA expression in normal human tissues for GSTT2 Gene

mRNA differential expression in normal tissues according to GTEx for GSTT2 Gene

This gene is overexpressed in Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for GSTT2 Gene

This gene is overexpressed in Skin (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTT2 Gene



Protein tissue co-expression partners for GSTT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTT2 Gene:

GSTT2

SOURCE GeneReport for Unigene cluster for GSTT2 Gene:

Hs.654462

mRNA Expression by UniProt/SwissProt for GSTT2 Gene:

P0CG29-GST2_HUMAN
Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.
genes like me logo Genes that share expression patterns with GSTT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GSTT2 Gene

Orthologs for GSTT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTT2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100686488 34
  • 81.56 (n)
  • 75 (a)
-- 35
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gstt2 34
  • 79.37 (n)
  • 77.87 (a)
Gstt2 35
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GSTT2 34
  • 98.91 (n)
  • 98.77 (a)
GSTT2B 35
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gstt2 34
  • 80.46 (n)
  • 78.28 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24816 34
zebrafish
(Danio rerio)
Actinopterygii zgc:66350 35
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1681 35
  • 30 (a)
ManyToMany
CG1702 35
  • 27 (a)
ManyToMany
CG30000 35
  • 31 (a)
ManyToMany
CG30005 35
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for GSTT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTT2 Gene

ENSEMBL:
Gene Tree for GSTT2 (if available)
TreeFam:
Gene Tree for GSTT2 (if available)

Paralogs for GSTT2 Gene

Paralogs for GSTT2 Gene

(3) SIMAP similar genes for GSTT2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GSTT2: view

Variants for GSTT2 Gene

Sequence variations from dbSNP and Humsavar for GSTT2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1126752 -- 23,982,630(+) AAGCT(C/T)GGCCA nc-transcript-variant
rs2719 -- 23,983,759(+) GTGCT(G/T)CTACT nc-transcript-variant
rs140195 -- 23,982,904(+) TGCCC(A/G/T)AGGAG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTT2 Gene

Variant ID Type Subtype PubMed ID
dgv35n47 CNV loss 21111241
dgv4528n100 CNV gain 25217958
dgv4532n100 CNV gain 25217958
dgv4534n100 CNV loss 25217958
dgv4535n100 CNV gain 25217958
dgv4536n100 CNV loss 25217958
dgv751n67 CNV loss 20364138
dgv8039n54 CNV gain 21841781
dgv826e199 CNV deletion 23128226
esv1449016 OTHER inversion 17803354
esv2421686 OTHER complex 20811451
esv2593346 CNV deletion 19546169
esv2656467 CNV deletion 23128226
esv2656800 CNV deletion 23128226
esv2667916 CNV deletion 23128226
esv2724041 CNV deletion 23290073
esv2724066 CNV deletion 23290073
esv2966013 CNV deletion 24192839
esv3034901 CNV deletion 24192839
esv3557984 CNV deletion 23714750
esv3575443 CNV gain 25503493
esv3575444 CNV gain 25503493
esv3584777 CNV loss 24956385
esv3893452 CNV gain+loss 25118596
esv3893453 CNV loss 25118596
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
esv6716 CNV loss 19470904
esv999560 CNV deletion 20482838
nsv1057737 CNV loss 25217958
nsv1059397 CNV gain 25217958
nsv1063251 CNV gain+loss 25217958
nsv1066891 CNV gain 25217958
nsv1072628 CNV deletion 25765185
nsv1072629 CNV deletion 25765185
nsv1110863 OTHER inversion 24896259
nsv1145372 CNV deletion 24896259
nsv1153441 CNV deletion 26484159
nsv1160735 CNV deletion 26073780
nsv1160736 OTHER complex 26073780
nsv197 CNV deletion 15895083
nsv436348 CNV deletion 17901297
nsv442792 CNV loss 18776908
nsv469844 CNV loss 16826518
nsv471424 CNV gain 19718026
nsv482074 CNV gain 20164927
nsv511075 OTHER complex 20534489
nsv511643 CNV loss 21212237
nsv512650 CNV loss 21212237
nsv526567 CNV gain 19592680
nsv588651 CNV gain 21841781
nsv588669 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv829105 CNV loss 20364138
nsv829109 CNV loss 20364138
nsv834155 CNV gain+loss 17160897
nsv953055 CNV deletion 24416366
nsv964607 CNV duplication 23825009
nsv979656 CNV duplication 23825009

Variation tolerance for GSTT2 Gene

Gene Damage Index Score: 7.80; 83.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTT2 Gene

Human Gene Mutation Database (HGMD)
GSTT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT2 Gene

Disorders for GSTT2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GSTT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon adenoma
  • adenomatous polyp of colon
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GSTT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTT2

Genetic Association Database (GAD)
GSTT2
Human Genome Epidemiology (HuGE) Navigator
GSTT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTT2
genes like me logo Genes that share disorders with GSTT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT2 Gene

Publications for GSTT2 Gene

  1. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. (PMID: 18449862) Matsuzawa D. … Iyo M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 65
  2. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. (PMID: 18268125) Wang S. … Perera F.P. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 22 46 65
  3. GSTT2 promoter polymorphisms and colorectal cancer risk. (PMID: 17250773) Jang S.G. … Park J.G. (BMC Cancer 2007) 3 22 46 65
  4. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3 22 65
  5. Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PMID: 7789971) Tan K.L. … Board P.G. (Genomics 1995) 2 3 22 65

Products for GSTT2 Gene

Sources for GSTT2 Gene

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