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Aliases for GSTT2 Gene

Aliases for GSTT2 Gene

  • Glutathione S-Transferase Theta 2 (Gene/Pseudogene) 2 3
  • Glutathione S-Transferase Theta 2 2
  • GST Class-Theta-2 4
  • EC 2.5.1.18 4

External Ids for GSTT2 Gene

Summaries for GSTT2 Gene

Entrez Gene Summary for GSTT2 Gene

  • Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTT2 Gene

GSTT2 (Glutathione S-Transferase Theta 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with GSTT2 include barretts adenocarcinoma and colon adenoma. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot for GSTT2 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity

Gene Wiki entry for GSTT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT2 Gene

Genomics for GSTT2 Gene

Genomic Location for GSTT2 Gene

Start:
23,980,123 bp from pter
End:
23,983,915 bp from pter
Size:
3,793 bases
Orientation:
Plus strand

Genomic View for GSTT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT2 Gene

Regulatory Elements for GSTT2 Gene

Proteins for GSTT2 Gene

  • Protein details for GSTT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG29-GST2_HUMAN
    Recommended name:
    Glutathione S-transferase theta-2
    Protein Accession:
    P0CG29
    Secondary Accessions:
    • O60665
    • P30712
    • Q6IPV7
    • Q9HD76

    Protein attributes for GSTT2 Gene

    Size:
    244 amino acids
    Molecular mass:
    27506 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for GSTT2 Gene

neXtProt entry for GSTT2 Gene

Proteomics data for GSTT2 Gene at MOPED

Post-translational modifications for GSTT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GSTT2 Gene

Domains for GSTT2 Gene

Gene Families for GSTT2 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

Protein Domains for GSTT2 Gene

UniProtKB/Swiss-Prot:

GST2_HUMAN
Domain:
  • Contains 1 GST C-terminal domain.:
    • P0CG29
  • Contains 1 GST N-terminal domain.:
    • P0CG29
Family:
  • Belongs to the GST superfamily. Theta family.:
    • P0CG29
genes like me logo Genes that share domains with GSTT2: view

Function for GSTT2 Gene

Molecular function for GSTT2 Gene

GENATLAS Biochemistry: glutathione-S-transferase 2,theta class,separated by 50kb from GSTT1,tighlty linked to DDT,in head to head disposition,likely a pseudogene with a splice site abnormality and a premature translation stop signal
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity

Enzyme Numbers (IUBMB) for GSTT2 Gene

Gene Ontology (GO) - Molecular Function for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GSTT2: view

Phenotypes for GSTT2 Gene

MGI mutant phenotypes for GSTT2:
inferred from 1 alleles
GenomeRNAi human phenotypes for GSTT2:
genes like me logo Genes that share phenotypes with GSTT2: view

miRNA for GSTT2 Gene

miRTarBase miRNAs that target GSTT2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GSTT2 Gene

Localization for GSTT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTT2 Gene COMPARTMENTS Subcellular localization image for GSTT2 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GSTT2: view

Pathways for GSTT2 Gene

genes like me logo Genes that share pathways with GSTT2: view

Interacting Proteins for GSTT2 Gene

Selected Interacting proteins: P0CG29-GST2_HUMAN for GSTT2 Gene via I2D

Symbol External ID(s) Details
GSTT2B

Gene Ontology (GO) - Biological Process for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GSTT2: view

Compounds for GSTT2 Gene

(12) HMDB Compounds for GSTT2 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(1) Drugbank Compounds for GSTT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-Hexylglutathione
target

(1) Novoseek inferred chemical compound relationships for GSTT2 Gene

Compound -log(P) Hits PubMed IDs
gsts 87.8 3
genes like me logo Genes that share compounds with GSTT2: view

Transcripts for GSTT2 Gene

mRNA/cDNA for GSTT2 Gene

Unigene Clusters for GSTT2 Gene

Glutathione S-transferase theta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT2 Gene

No ASD Table

Relevant External Links for GSTT2 Gene

GeneLoc Exon Structure for
GSTT2
ECgene alternative splicing isoforms for
GSTT2

Expression for GSTT2 Gene

mRNA expression in normal human tissues for GSTT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTT2 Gene

This gene is overexpressed in Adrenal Gland (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GSTT2 Gene

SOURCE GeneReport for Unigene cluster for GSTT2 Gene Hs.654462

mRNA Expression by UniProt/SwissProt for GSTT2 Gene

P0CG29-GST2_HUMAN
Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.
genes like me logo Genes that share expressions with GSTT2: view

Orthologs for GSTT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTT2 36
  • 98.91 (n)
  • 98.77 (a)
GSTT2B 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 45 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 75 (a)
OneToMany
LOC100686488 36
  • 81.56 (n)
  • 75 (a)
mouse
(Mus musculus)
Mammalia Gstt2 36
  • 79.37 (n)
  • 77.87 (a)
Gstt2 16
Gstt2 37
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gstt2 36
  • 80.46 (n)
  • 78.28 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24816 36
zebrafish
(Danio rerio)
Actinopterygii zgc:66350 37
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1681 37
  • 30 (a)
ManyToMany
CG1702 37
  • 27 (a)
ManyToMany
CG30000 37
  • 31 (a)
ManyToMany
CG30005 37
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for GSTT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTT2 Gene

ENSEMBL:
Gene Tree for GSTT2 (if available)
TreeFam:
Gene Tree for GSTT2 (if available)

Paralogs for GSTT2 Gene

Paralogs for GSTT2 Gene

Selected SIMAP similar genes for GSTT2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GSTT2: view

Variants for GSTT2 Gene

Sequence variations from dbSNP and Humsavar for GSTT2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2719 -- 23,983,759(+) GTGCT(G/T)CTACT utr-variant-3-prime
rs140188 -- 23,981,861(+) CCCCA(C/G)CTCTC intron-variant
rs1126752 -- 23,982,630(+) AAGCT(C/T)GGCCA reference, missense
rs4987176 -- 23,982,976(+) TGGGG(A/G)ACAGG missense, reference
rs60718122 -- 23,982,936(+) GCCAT(A/G)GACCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GSTT2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
nsv436348 CNV Deletion 17901297
esv999560 CNV Deletion 20482838
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
esv2593346 CNV Deletion 19546169
nsv512650 CNV Loss 21212237
nsv829105 CNV Loss 20364138
esv2724066 CNV Deletion 23290073
nsv9878 CNV Gain+Loss 18304495
esv2667916 CNV Deletion 23128226
dgv35n47 CNV Loss 21111241
esv6716 CNV Loss 19470904
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
esv1449016 OTHER Inversion 17803354
esv2656467 CNV Deletion 23128226
nsv511643 CNV Loss 21212237
esv2656800 CNV Deletion 23128226
dgv751n67 CNV Loss 20364138
nsv914614 CNV Loss 21882294
dgv826e199 CNV Deletion 23128226
nsv829109 CNV Loss 20364138
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294
nsv471424 CNV Duplication 19718026
nsv482074 CNV Gain 20164927
dgv4913n71 CNV Gain 21882294

Relevant External Links for GSTT2 Gene

HapMap Linkage Disequilibrium report
GSTT2
Human Gene Mutation Database (HGMD)
GSTT2

Disorders for GSTT2 Gene

Relevant External Links for GSTT2

Genetic Association Database (GAD)
GSTT2
Human Genome Epidemiology (HuGE) Navigator
GSTT2
genes like me logo Genes that share disorders with GSTT2: view

No data available for UniProtKB/Swiss-Prot for GSTT2 Gene

Publications for GSTT2 Gene

  1. Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PMID: 7789971) Tan K.L. … Board P.G. (Genomics 1995) 2 3 23
  2. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3 23
  3. GSTT2 promoter polymorphisms and colorectal cancer risk. (PMID: 17250773) Jang S.G. … Park J.G. (BMC Cancer 2007) 3 23 49
  4. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. (PMID: 18268125) Wang S. … Perera F.P. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 23 49
  5. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. (PMID: 18449862) Matsuzawa D. … Iyo M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 49

Products for GSTT2 Gene

Sources for GSTT2 Gene

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