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GSTT2 Gene

protein-coding   GIFtS: 62
GCID: GC22P024322

Glutathione S-Transferase Theta 2

  See GSTT2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Theta 21 2
GST Class-Theta-22 3
GSTT2B2
Glutathione S-Transferase Theta-22
Glutathione S-Transferase Theta-2B2
EC 2.5.1.183

External Ids:    HGNC: 46421   Entrez Gene: 29532   Ensembl: ENSG000000999847   OMIM: 6004375   UniProtKB: P0CG293   

Export aliases for GSTT2 gene to outside databases

Previous GC identifers: GC22P021018 GC22P022646 GC22P022652 GC22P007270


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTT2 Gene:
Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the
conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be
divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55%
amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta
genes have a similar structure, being composed of five exons with identical exon/intron boundaries. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GSTT2 Gene:
GSTT2 (glutathione S-transferase theta 2) is a protein-coding gene. Diseases associated with GSTT2 include barrett's adenocarcinoma, and malignant pleural mesothelioma. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTT1.

UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Has a sulfatase activity

Gene Wiki entry for GSTT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_187633.1  NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTT2 gene promoter:
         GR   p53   AP-1   SREBP-1c   GR-beta   ATF-2   SREBP-1a   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTT2 promoter sequence
   Search Chromatin IP Primers for GSTT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

GSTT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTT2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024322:  view genomic region     (about GC identifiers)

Start:
24,322,314 bp from pter      End:
24,326,106 bp from pter
Size:
3,793 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29 (See protein sequence)
Recommended Name: Glutathione S-transferase theta-2  
Size: 244 amino acids; 27506 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for GSTT2:
4MPF (3D)    
Secondary accessions: O60665 P30712 Q6IPV7 Q9HD76

Explore the universe of human proteins at neXtProt for GSTT2: NX_P0CG29

Explore proteomics data for GSTT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GSTT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000845.1  
    ENSEMBL proteins: 
     ENSP00000215780   ENSP00000385765  
    Reactome Protein details: P0CG29

    GSTT2 Human Recombinant Protein Products:

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    Novus Biologicals GSTT2 Proteins
    Novus Biologicals GSTT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTT2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GSTT2 

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    Abcam antibodies for GSTT2 (P0CG30, Q6IPV7)
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    LSBio Antibodies in human, mouse, rat for GSTT2

    GSTT2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GSTT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    4 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P0CG29

    ProtoNet protein and cluster: P0CG29

    UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29
    Similarity: Belongs to the GST superfamily. Theta family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GST2_HUMAN, P0CG29
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Has a sulfatase activity
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTT2:
    glutathione-S-transferase 2,theta class,separated by 50kb from GSTT1,tighlty linked to DDT,in head to head
    disposition,likely a pseudogene with a splice site abnormality and a premature translation stop signal

         Enzyme Number (IUBMB): EC 2.5.1.181

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GSTT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTT2:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gstt2):
     normal 

    Find genes that share phenotypes with GSTT2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTT2

    miRNA
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    miRTarBase miRNAs that target GSTT2:
    hsa-mir-26b-5p (MIRT028974)

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    Search for qRT-PCR Assays for microRNAs that regulate GSTT2
    SwitchGear 3'UTR luciferase reporter plasmidGSTT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GSTT2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GSTT2 (NM_000854)
    Sino Biological Human cDNA Clone for GSTT2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTT2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GST2_HUMAN, P0CG29: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with GSTT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    5Oxidative Stress
    Oxidative Stress


    Find genes that share SuperPaths with GSTT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for GSTT2
        Oxidative Stress
    metapathway biotransformation
    Glutathione metabolism


    1 Reactome Pathway for GSTT2
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for GSTT2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GSTT2
    Interactions:

        GeneGlobe Interaction Network for GSTT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for GSTT2 (P0CG293 ENSP000002157804) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTT2BP0CG303, ENSP000002907654I2D: score=1 STRING: ENSP00000290765
    OLA1ENSP000002847194STRING: ENSP00000284719
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    ARHGDIGENSP000002194094STRING: ENSP00000219409
    QARSENSP000003075674STRING: ENSP00000307567
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTT2 (GST2)

    Selected HMDB Compounds for GSTT2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for GSTT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Hexylglutathione-- --target--10592235

    1 Novoseek inferred chemical compound relationship for GSTT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 87.8 3 15746163 (1), 17982697 (1), 18664505 (1)



    Find genes that share compounds with GSTT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GSTT2 gene: 
    NM_000854.3  

    Unigene Cluster for GSTT2:

    Glutathione S-transferase theta 2
    Hs.654462  [show with all ESTs]
    Unigene Representative Sequence: CD013992
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215780(uc002zzb.4 uc002zzc.4) ENST00000402588
    miRNA
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    GenScript: all cDNA clones in your preferred vector: GSTT2 (NM_000854)
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    Additional mRNA sequence: 

    AK312043.1 BC002415.1 BC146929.1 BC146940.1 BC146943.1 CR456374.1 CR456500.1 CR456929.1 
    L38503.1 

    10 DOTS entries:

    DT.315274  DT.100757482  DT.120669389  DT.100738109  DT.95264485  DT.315273  DT.92420542  DT.101954193 
    DT.101983385  DT.101983387 

    Selected AceView cDNA sequences (see all 94):

    BU584249 BQ613805 BM976631 CD014128 BQ012116 CR612277 CR590685 CR601749 
    BQ011989 N71130 BX119070 CD013993 CR456929 AA447946 BU173033 AA009800 
    AA490208 BQ422834 CF529648 BQ267814 BC002415 CR456374 BF969736 CD013992 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GSTT2 Expression
    About this image


    GSTT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    GSTT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654462

    UniProtKB/Swiss-Prot: GST2_HUMAN, P0CG29
    Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar
    cells, alveolar macrophages and alveolar type II cells

        Custom PCR Arrays for GSTT2
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    QuantiFast Probe-based Assays in human, mouse, rat GSTT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTT2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstt21 , 5 glutathione S-transferase, theta 21, 5 79.37(n)1
    77.87(a)1
      10 (38.58 cM)5
    148721  NM_010361.21  NP_034491.21 
     758318455 
    chicken
    (Gallus gallus)
    Aves --
    Glutathione S-transferase theta-1
    47(a)
    many ↔ many
    15(8101744-8107045)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    GL344539.1(13835-19538)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.248162 Xenopus laevis transcribed sequence with weak similarity more 74.56(n)    48050565 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:663506
    zgc:66350
    39(a)
    many ↔ many
    5(10954245-10963943) ENSDARG00000095464
    fruit fly
    (Drosophila melanogaster)
    Insecta CG300006
    CG16816
    (see all 4)
    --
    31(a)
    30(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2R(5493495-5494689)
    X(13298789-13303249)


    ENSEMBL Gene Tree for GSTT2 (if available)
    TreeFam Gene Tree for GSTT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTT2 gene
    GSTT2B1 2  GSTT12  
    3 SIMAP similar genes for GSTT2 using alignment to 6 protein entries:     GST2_HUMAN (see all proteins):
    GSTT2B    GSTT1    Em

    Find genes that share paralogs with GSTT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTT2 (see all 24)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901886851,2
    --24324050(+) CCCCCC/GACCTC 1 -- int10--------
    rs1401881,2
    C,F,A,H--24324052(+) CCCCAG/CCTCTC 1 -- int14Minor allele frequency- C:0.47NS EA 418
    rs2007411421,2
    --24324062(+) ATCTT-/CCAGCC 1 -- int10--------
    rs1827816281,2
    --24324311(+) TGGCTA/GCAGAG 1 -- int10--------
    rs3731124971,2
    C--24324316(+) GCAGAA/GTGATG 1 -- int10--------
    rs1995228391,2
    --24324883(+) CTGACC/TTGCAG 2 L syn10--------
    rs2009253051,2
    F--24325006(+) ATCAGA/GGAGTA 1 -- int11Minor allele frequency- G:0.43EU 701
    rs2017236571,2
    F--24325024(+) GTAGGT/CCGGGG 1 -- int11Minor allele frequency- C:0.40EU 963
    rs1496861211,2
    C,F--24325047(+) CCACTG/CTCTGC 1 -- int11Minor allele frequency- C:0.35EU 1039
    rs782843831,2
    C,F--24325062(+) ATCAGG/ATGTTG 2 /M /V mis11Minor allele frequency- A:0.15EU 1235

    HapMap Linkage Disequilibrium report for GSTT2 (24322314 - 24326106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GSTT2 (see all 44):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999560CNV Deletion20482838
    esv2593346CNV Deletion19546169
    nsv436348CNV Deletion17901297
    esv2724066CNV Deletion23290073
    esv2667916CNV Deletion23128226
    esv2724041CNV Deletion23290073
    esv2656800CNV Deletion23128226
    dgv826e199CNV Deletion23128226
    esv2656467CNV Deletion23128226
    nsv471424CNV Duplication19718026

    Human Gene Mutation Database (HGMD): GSTT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTT2
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600437    OMIM disorders: --

    2 diseases for GSTT2:    
    About MalaCards
    barrett's adenocarcinoma    malignant pleural mesothelioma


    Find genes that share disorders with GSTT2           About GenesLikeMe

    Genetic Association Database (GAD): GSTT2
    Human Genome Epidemiology (HuGE) Navigator: GSTT2 (19 documents)

    Export disorders for GSTT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTT2 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with GSTT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GSTT2 promoter polymorphisms and colorectal cancer risk. (PubMed id 17250773)1, 4, 9 Jang S.G....Park J.G. (BMC Cancer 2007)
    2. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PubMed id 9729470)1, 3, 9 Coggan M....Board P. (Biochem. J. 1998)
    3. Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PubMed id 7789971)1, 3, 9 Tan K.L.... Board P.G. (Genomics 1995)
    4. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. (PubMed id 18449862)1, 4, 9 Matsuzawa D....Iyo M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. (PubMed id 18268125)1, 4, 9 Wang S....Perera F.P. (amp 2008)
    6. Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. (PubMed id 19860743)1, 4 Wang S....Perera F.P. (Ann. Hum. Genet. 2010)
    7. Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia. (PubMed id 19528963)1, 4 RodrA-guez-Santiago B....PAcrez-Jurado L.A. (Mol. Psychiatry 2010)
    8. Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy. (PubMed id 20437850)1, 4 Canova C....Simonato L. (Tumori 2010)
    9. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (amp 2010)
    10. Methods for detecting interactions between genetic polymorphisms and prenatal environment exposure with a mother-child design. (PubMed id 19582785)1, 4 Wang S....Perera F.P. (Genet. Epidemiol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2953 HGNC: 4642 AceView: GSTT2 Ensembl:ENSG00000099984 euGenes: HUgn2953
    ECgene: GSTT2 Kegg: 2953 H-InvDB: GSTT2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GSTT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GSTT2 gene:
    Search GeneIP for patents involving GSTT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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