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GSTT1 Gene

protein-coding   GIFtS: 68
GCID: GC22M025171

Glutathione S-Transferase Theta 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Theta 11 2
Glutathione Transferase T1-12 3
GST Class-Theta-12 3
EC 2.5.1.183 8
Glutathione S-Transferase Theta-12

External Ids:    HGNC: 46411   Entrez Gene: 29522   Ensembl: ENSG000001846747   OMIM: 6004365   UniProtKB: P307113   

Export aliases for GSTT1 gene to outside databases

Previous GC identifers: GC22M021072 GC22M020995 GC22M022700 GC22M022706 GC22M024377 GC22M024341 GC22M007324 GC22M024378 GC22M024380 GC22M024506 GC22M024776 GC22M024952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTT1 Gene:
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the
conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be
divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The
GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in
human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2
genes have a similar structure, being composed of five exons with identical exon/intron boundaries. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GSTT1 Gene:
GSTT1 (glutathione S-transferase theta 1) is a protein-coding gene. Diseases associated with GSTT1 include asbestosis, and oral cancer. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and
4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide

Gene Wiki entry for GSTT1 Gene

PharmGKB "VIP" summary for GSTT1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:NT_187633.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTT1 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTT1 promoter sequence
   Search Chromatin IP Primers for GSTT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

GSTT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTT1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M025171:  view genomic region     (about GC identifiers)

Start:
24,376,133 bp from pter      End:
24,384,680 bp from pter
Size:
8,548 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711 (See protein sequence)
Recommended Name: Glutathione S-transferase theta-1  
Size: 240 amino acids; 27335 Da
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for GSTT1:
2C3N (3D)        2C3Q (3D)        2C3T (3D)    
Secondary accessions: O00226 Q5TZY2 Q969K8 Q96IY3

Explore the universe of human proteins at neXtProt for GSTT1: NX_P30711

Explore proteomics data for GSTT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for GSTT1 (P30711)
     YIFAKKN  ARVDEYLAWQHT 


    See GSTT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000844.2  
    ENSEMBL proteins: 
     ENSP00000389481   ENSP00000406746   ENSP00000248935   ENSP00000400343   ENSP00000414223  
     ENSP00000396227   ENSP00000406003   ENSP00000399037   ENSP00000397362   ENSP00000401632  
    Reactome Protein details: P30711

    GSTT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for GSTT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GSTT1
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    Novus Biologicals GSTT1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTT1
    Browse Proteins at Cloud-Clone Corp.

    GSTT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSTT1
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    Abcam antibodies for GSTT1 (P30711, A8MPT4)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GSTT1
    LSBio Antibodies in human, mouse, rat for GSTT1

    GSTT1 Assay Products:

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    GenScript Custom Assay Services for GSTT1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    4 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P30711

    ProtoNet protein and cluster: P30711

    1 Blocks protein domain: IPB004045 Glutathione S-transferase

    UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
    Similarity: Belongs to the GST superfamily. Theta family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTT1_HUMAN, P30711
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and
    4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTT1:
    glutathione-S-transferase 1,theta class,deleted in bladder cancer

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA--
    GO:0004602glutathione peroxidase activity IDA9307035
    GO:0005515protein binding ----
    GO:0016740transferase activity ----
         
    GSTT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTT1:
     Increased viability after born 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gstt1):
     homeostasis/metabolism 

    GSTT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gstt1tm1Kfuj for GSTT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTT1

    miRNA
    Products:
        
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    Search for qRT-PCR Assays for microRNAs that regulate GSTT1
    SwitchGear 3'UTR luciferase reporter plasmidGSTT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTT1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTT1

    Clone
    Products:
         
    OriGene clones in human, mouse for GSTT1 (see all 6)
    OriGene ORF clones in mouse, rat for GSTT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTT1 (NM_000853)
    Sino Biological Human cDNA Clone for GSTT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTT1_HUMAN, P30711: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    GSTT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTT1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione conjugation0.60
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Aflatoxin B1 metabolism0.00
    3Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    4Metabolism
    Metabolism0.38
    5Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for GSTT1
        Naphthalene metabolism
    Glutathione metabolism

    4 BioSystems Pathways for GSTT1
        Aflatoxin B1 metabolism
    glutathione-mediated detoxification I
    metapathway biotransformation
    Glutathione metabolism


    1 Reactome Pathway for GSTT1
        Glutathione conjugation

    2 PharmGKB Pathways for GSTT1
        Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    4 Kegg Pathways  (Kegg details for GSTT1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTT1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSTT1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GSTT1 (ENSP000004016324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ensp: ENSP000002489354STRING: ensp: ENSP00000248935
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0014070response to organic cyclic compound IEA--
    GO:0042493response to drug IEA--
    GO:0044281small molecule metabolic process TAS--

    GSTT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTT1

    Selected HMDB Compounds for GSTT1 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    ChlorineCl2 (see all 13)16887-00-6--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--

    5 DrugBank Compounds for GSTT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17372252 17381051 17653748 17617661 17333241
    CisplatinCDDP (see all 7)15663-27-1enzymesubstrate11081456
    EtoposideEPEG (see all 4)33419-42-0enzymesubstrate1315544
    CarboplatinCBDCA (see all 2)41575-94-4enzymesubstrate--
    OxaliplatinDiaminocyclohexane Oxalatoplatinum (see all 4)61825-94-3enzymesubstrate--

    Selected Novoseek inferred chemical compound relationships for GSTT1 gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 94.3 19 7788840 (1), 19640174 (1), 11553769 (1), 15382272 (1) (see all 19)
    epoxide 76.9 29 11122850 (1), 12359356 (1), 12717779 (1), 16980312 (1) (see all 28)
    diepoxybutane 70.3 70 7788840 (7), 8671741 (6), 15036125 (5), 12694746 (3) (see all 12)
    1,3-butadiene 68.6 13 8524342 (1), 15036120 (1), 7606200 (1), 8980697 (1) (see all 12)
    1-hydroxypyrene 65.6 5 11641039 (2), 11323399 (2), 11418090 (1)
    s-phenylmercapturic acid 63.6 9 17885617 (3), 15533900 (2), 20100551 (1)
    mspi 62.7 14 10813720 (1), 15734083 (1), 19963114 (1), 11408954 (1) (see all 13)
    styrene oxide 58.4 14 9654239 (5), 12016165 (1), 12694745 (1), 18608187 (1)
    n-(2-hydroxyethyl)valine 56.8 9 9826084 (3), 11352866 (2)
    styrene 54.8 21 12016165 (5), 12717779 (2), 14751678 (2), 16424821 (2) (see all 11)

    2 PharmGKB related drug/compound annotations for GSTT1 gene    About this table
    Drug/compound PharmGKB Annotation
    Drugs For Treatment Of TuberculosisCA  
    isoniazidCA  



    GSTT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GSTT1 gene: 
    NM_000853.2  

    Unigene Cluster for GSTT1:

    Glutathione S-transferase theta 1
    Hs.268573  [show with all ESTs]
    Unigene Representative Sequence: CR749711
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436103 ENST00000417831 ENST00000248935(uc002zze.4 uc010gug.3 uc011ajl.2 uc010guh.3)
    ENST00000426209 ENST00000458231 ENST00000417489 ENST00000417870 ENST00000418883
    ENST00000480898 ENST00000428175 ENST00000447865 ENST00000486544(uc010gui.1)
    ENST00000439996
    miRNA
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    GenScript: all cDNA clones in your preferred vector: GSTT1 (NM_000853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GSTT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTT1
      QuantiTect SYBR Green Assays in human, mouse, rat GSTT1
      QuantiFast Probe-based Assays in human, mouse, rat GSTT1

    Additional mRNA sequence: 

    AF435971.1 AJ867757.1 AJ867758.1 AJ874719.1 AK311138.1 AL359937.1 BC007065.1 BC064833.1 
    BT019951.1 CR456499.1 CR749711.1 X79389.1 

    20 DOTS entries:

    DT.86837198  DT.120669464  DT.95137787  DT.451653  DT.100711917  DT.100886963  DT.95154632  DT.100716942 
    DT.100886973  DT.99962693  DT.100724662  DT.91765800  DT.40116481  DT.97859048  DT.120669323  DT.97790036 
    DT.306274  DT.443738  DT.91765808  DT.120669449 

    Selected AceView cDNA sequences (see all 235):

    AA297181 AA171580 BM562922 CR622903 F05601 BM851576 AV648716 BM766149 
    BI517322 H55601 BQ645697 BU943479 BI761235 BM821265 BM830104 BE746521 
    BX401239 BQ127965 BM829777 T97888 AA297369 BM006030 CR599021 CA313466 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                      -     -           -     -                                                   
    SP2:                                      -     -           -     -     -                                             
    SP3:                                      -     -     -     -     -                                                   
    SP4:                                      -     -     -     -     -     -                                             
    SP5:                                      -     -           -     -     -     -                                       


    ECgene alternative splicing isoforms for GSTT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGGTCTG
    GSTT1 Expression
    About this image


    GSTT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    GSTT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268573

    UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
    Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in
    Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger
    bronchioles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTT1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSTT1
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTT1
    QuantiTect SYBR Green Assays in human, mouse, rat GSTT1
    QuantiFast Probe-based Assays in human, mouse, rat GSTT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for GSTT1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstt15 glutathione S-transferase, theta 1   --   10 (38.58 cM) 75783813 
    chicken
    (Gallus gallus)
    Aves --
    Glutathione S-transferase theta-1
    52(a)
    many ↔ many
    15(8101744-8107045)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    GL344539.1(13835-19538)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1376958112   -- 75.43(n)    137695811 
    zebrafish
    (Danio rerio)
    Actinopterygii gstt1a6
    glutathione S-transferase theta 1a
    50(a)
    many ↔ many
    8(31635153-31639308) ENSDARG00000042428
    fruit fly
    (Drosophila melanogaster)
    Insecta gfzf6
    CG300006
    (see all 30)
    --
    6(a)
    35(a)
    (see all 30)
    many ↔ many
    many ↔ many
    (see all 30)
    3R(2971596-2976661)
    2R(5493495-5494689)


    ENSEMBL Gene Tree for GSTT1 (if available)
    TreeFam Gene Tree for GSTT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for GSTT1 gene
    GSTT2B2  GSTT22  
    4 SIMAP similar genes for GSTT1 using alignment to 12 protein entries:     GSTT1_HUMAN (see all proteins):
    CNOT2    GSTT2    GSTT2B    Em

    GSTT1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for GSTT1 (see all 9)
    PGOHUM00000259693 PGOHUM00000259694 PGOHUM00000259695 PGOHUM00000246284 PGOHUM00000259696


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    GSTT1_HUMAN, P30711: The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is
    coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype
    can catalyze the glutathione conjugation of dichloromethane


    Selected SNPs for GSTT1 (see all 166)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783412681,2
    C--7323843(+) TATCTA/CAAAAA 1 -- ds50010--------
    rs1929208551,2
    --24375942(+) GATCCA/CCCTGC 1 -- ds50010--------
    rs27393451,2
    C,A,H--24375989(+) ccaccA/Gcacgc 1 -- ds50012Minor allele frequency- G:0.04NA 122
    rs27393461,2
    C,H--24375993(+) cgcacC/Gcggcc 1 -- ds50014Minor allele frequency- G:0.04WA NA 126
    rs1464601281,2
    --24376208(+) TAAAGG/TACACA 1 -- ut310--------
    rs46301,2
    C,F,A--24376322(-) CTTGCT/CTAAGA 1 -- ut31 ese318Minor allele frequency- C:0.24NA MN EA WA 1118
    rs1430795601,2
    F--24376423(+) CCAGCT/CCACCG 2 /* /W --1Minor allele frequency- C:0.00NA 3324
    rs1854991981,2
    --24376428(+) TCACCA/GGATCA 2 R W mis10--------
    rs763234591,2
    C--24376534(+) AGGTCA/CTCCCC 2 E D mis10--------
    rs773009081,2
    C--24376536(+) GTCCTC/TCCCCA 2 K E mis10--------
    rs1446863261,2
    C,F--24376584(+) GGGTCG/AGCCTT 2 /R /* stg11Minor allele frequency- A:0.00NA 3384
    rs1999812591,2
    C--24376803(+) GGTTCA/TCCTGC 1 -- int11Minor allele frequency- T:0.00EU 841
    rs1879580131,2
    C--24376817(+) CAGCAC/TTCACA 1 -- int10--------
    rs22349531,2,,4
    C--24376833(-) TCACGG/AAGCTG 2 /K /E mis1 ese32Minor allele frequency- A:0.01NA 80
    rs22666371,2,,4
    C,F--24376845(-) ACCTCG/ATAGCC 2 /I /V mis17Minor allele frequency- A:0.05NA MN WA 676
    rs1398819981,2
    C--24376865(+) AGATGA/TGAGGA 2 H L mis10--------
    rs1480964611,2
    C,F--24376909(+) TCCTCG/AAGCAA 2 /L syn12Minor allele frequency- A:0.00NA EU 4671
    rs22666331,2,,4
    C,F,H--24376929(-) AGTTGG/AATGTG 2 /N /D mis14Minor allele frequency- A:0.01NA MN NS 366
    rs1926242931,2
    C--24376939(+) TCTGCC/TAGGGT 2 L syn10--------
    rs1418296091,2
    F--24376945(+) AGGGTG/AGCTGC 2 /A syn11Minor allele frequency- A:0.00NA 3612
    rs22666361,2
    F--24376996(-) CAGGTG/AATGTT 2 /V syn12Minor allele frequency- A:0.02NA MN 258
    rs1403081,2
    C,F,H--24377034(+) ACTGGG/AGTAGG 1 -- int17Minor allele frequency- A:0.11NA WA 248
    rs1135403671,2
    C,F--24377240(+) GTGCCC/TGCCAC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1884722311,2
    --24377248(+) CACCAC/TGCCCA 1 -- int10--------
    rs1813068021,2
    --24377350(+) CGCCTC/TCCAAA 1 -- int10--------
    rs1848192151,2
    --24377454(+) TAAGTA/GAAATA 1 -- int10--------
    rs1900676101,2
    --24377705(+) CCTGAC/TCTCAG 1 -- int10--------
    rs1496892721,2
    --24377891(+) AAGCCA/GTTCCT 1 -- int10--------
    rs1818163931,2
    --24378023(+) AGCAGA/GGAGAT 1 -- int10--------
    rs1458361241,2
    --24378105(+) CATTCA/GAGATA 1 -- int10--------
    rs1861133161,2
    --24378183(+) AGAGAA/GCAGCC 1 -- int10--------
    rs1163174261,2
    F--24378208(+) CCTGAC/TACAGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1489807251,2
    --24378238(+) GGGGGA/TGTTTA 1 -- int10--------
    rs1892531711,2
    --24378650(+) TGACCC/GATAAT 1 -- int10--------
    rs1819648481,2
    --24378651(+) GACCCA/GTAATC 1 -- int10--------
    rs1850596061,2
    --24378652(+) ACCCAA/TAATCA 1 -- int10--------
    rs1909402011,2
    --24378654(+) CCATAA/GTCAAG 1 -- int10--------
    rs28440081,2
    C,A--24378805(+) aaaccT/Cggtct 1 -- int16Minor allele frequency- C:0.04NA 130
    rs348613381,2
    C,F--24378934(+) AGATCG/ACACCA 1 -- int13Minor allele frequency- A:0.33NA 6
    rs1506014021,2
    F--24379378(+) GGCCCG/AGAGGC 2 /R /W mis11Minor allele frequency- A:0.00NA 3594
    rs2016586591,2
    C--24379392(+) TTCTCC/TGCAGA 2 Q R mis10--------
    rs115506051,2
    C,F--24379402(-) AGCACA/CCGACT 2 T P mis1 ese33Minor allele frequency- C:0.00NA EU 4504
    rs1417593721,2
    C,F--24379411(+) CTGCCA/GTGCCA 2 R W mis11Minor allele frequency- G:0.00NA 3602
    rs1462303181,2
    C,F--24379487(+) TTGCGC/TGTCAG 2 T syn12Minor allele frequency- T:0.00NA EU 4619
    rs22347341,2
    C,F--24379524(-) TGACCC/TCCACA 1 -- int13Minor allele frequency- T:0.11NA WA 192
    rs1423524691,2
    --24379952(+) GCAGTC/GTCAGC 1 -- int10--------
    rs1917203371,2
    --24379979(+) TTTTAC/TAGGAG 1 -- int10--------
    rs1464198091,2
    --24380052(+) AGGCTC/GGTCTT 1 -- int10--------
    rs1829819941,2
    --24380230(+) CCTAGA/GGCACA 1 -- int10--------
    rs1390190661,2
    --24380283(+) CCCAAA/GCTTTT 1 -- int10--------
    rs1431521131,2
    C--24380335(+) ATGTTC/TAGAGA 1 -- int10--------
    rs1504281271,2
    --24380366(+) AGAGAC/GAGCTT 1 -- int10--------
    rs1385900551,2
    --24380437(+) CCACTC/TTCATC 1 -- int10--------
    rs60040341,2
    C,F,A--24380443(+) TCATCT/CGCTGG 1 -- int13Minor allele frequency- C:0.20NA WA 122
    rs1148097701,2
    F--24380563(+) GTAGTT/GTGGCT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs38040721,2
    C--24380773(+) GGTTGA/GGCATG 1 -- int10--------
    rs105490551,2
    C--24380844(+) GGGCT-/ACACACG 1 -- int10--------
    rs2003989471,2
    --24380849(+) ACACA-/CGTGTCC 1 -- int10--------
    rs1403091,2
    C,F--24381083(+) GAAGAA/CGGGCC 1 -- int18Minor allele frequency- C:0.12NA WA 250
    rs1140444681,2
    C,F--24381115(+) TCATCG/AGAGGT 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1925141571,2
    --24381148(+) GATGAA/GCTTTA 1 -- int10--------
    rs1835466301,2
    --24381182(+) TAGGGA/GAAGGG 1 -- int10--------
    rs1403101,2
    C,F--24381406(+) CCCCAT/CGGTGG 1 -- int18Minor allele frequency- C:0.32NA WA CSA 249
    rs22347351,2
    C,F--24381652(-) TCCTGT/GTCTAA 1 -- int13Minor allele frequency- G:0.09NA MN 264
    rs178561991,2
    H--24381766(+) GGGCAA/CAGGCA 2 C F mis14Minor allele frequency- C:0.00NS EA 370
    rs1995219201,2
    C--24381773(+) GGCATC/TGCTTA 2 N D mis10--------
    rs1492872261,2
    C--24381811(+) GGTGGA/GTGGTG 1 -- int10--------
    rs1446282721,2
    --24381938(+) CCCTGC/TGGGAG 1 -- int10--------
    rs1866387501,2
    --24381965(+) CACCGG/TCTGGT 1 -- int10--------
    rs1393818751,2
    C--24382359(+) CCCAAA/GCTTTT 1 -- int10--------
    rs1923438581,2
    --24382471(+) CAGGTA/GTGAGC 1 -- int10--------
    rs1847909151,2
    --24382473(+) GGTGTA/GAGCCA 1 -- int10--------
    rs2016248551,2
    C--24382612(+) CCTCT-/TGTCC 
            
    TGTCC
    1 -- int10--------
    rs1459505881,2
    --24382998(+) GCAGAG/TGACAA 1 -- int10--------
    rs81405851,2
    C,F,A--24383013(+) TcgggC/Tggcag 1 -- int11Minor allele frequency- T:0.14WA 118
    rs1143077491,2
    C,F--24383171(+) AAGCCG/CGCAGA 1 -- int11Minor allele frequency- C:0.05WA 118
    rs1896333071,2
    --24383181(+) ATCATC/TTGATG 1 -- int10--------
    rs1929745361,2
    --24383187(+) TGATGA/TCAGGA 1 -- int10--------
    rs1398091971,2
    C--24383225(+) GAAATC/TCCATC 1 -- int10--------
    rs1842534621,2
    --24383324(+) GAACCC/TGGGAG 1 -- int10--------
    rs1421391191,2
    --24383439(+) CAGGAG/TGAACA 1 -- int10--------
    rs1891137741,2
    --24383609(+) TTGACC/TTCTCT 1 -- int10--------
    rs1463666761,2
    C--24383659(+) TTTTG-/TTTTTT 1 -- int10--------
    rs1403131,2
    C,F,A,H--24383954(+) AGCCCC/TGACTC 1 -- int17Minor allele frequency- T:0.34MN NA WA 430
    rs3761789631,2
    C--24384091(+) CTTTTC/TGGTTC 1 -- int10--------
    rs3684243461,2
    C--24384116(+) TGGACC/GTACCT 1 -- int10--------
    rs115506061,2
    C--24384143(-) CGAGCC/TGCGCA 2 P L mis10--------
    rs22666351,2,,4
    C,F,H--24384171(-) TCTTTG/ACCAAG 2 /T /A mis16Minor allele frequency- A:0.01NS NA 1008
    rs561061371,2
    C,F--24384219(+) GTACAG/ACTCCA 2 /L syn11Minor allele frequency- A:0.03NA 3614
    rs65194971,2
    C,F,A--24384287(+) AGTGCC/GAGGAC 1 -- us2k13Minor allele frequency- G:0.21NA CSA WA 121
    rs1393658061,2
    --24384692(+) TCCTTC/GGTGCC 1 -- us2k10--------
    rs1500277701,2
    --24384707(+) AGTGGC/TAAAGC 1 -- us2k10--------
    rs362114001,2
    C--24384920(-) GGGGGC/GTGGAC 1 -- us2k10--------
    rs96243831,2
    F--24384945(+) GAGCCA/GTAAGC 1 -- us2k10--------
    rs1862908601,2
    --24384969(+) TTGCTA/GCCATG 1 -- us2k10--------
    rs1892688291,2
    --24385018(+) TAAAAC/TGAATC 1 -- us2k10--------
    rs59966571,2
    C,F,A,H--24385105(+) CAACTG/Atttta 1 -- us2k110Minor allele frequency- A:0.17EA NS WA 1172
    rs60040351,2
    C,F,H--24385247(+) aggtgC/Tgcaca 1 -- us2k14Minor allele frequency- T:0.20EA NS NA WA 270
    rs1477130771,2
    --24385267(+) AGCTAA/GTTAAA 1 -- us2k10--------
    rs1809530691,2
    --24385273(+) TTAAAA/GAAAAT 1 -- us2k10--------
    rs1426613151,2
    --24385277(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs1862220681,2
    --24385278(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs346019951,2
    ----24383146(+) GTAAT-/CCCCAG 1 -- int10--------
    rs3747699361,2
    ----24383079(+) GACTCC/TTCTCA 1 -- int10--------
    rs3724397451,2
    ----24381142(+) TTCAGA/CATGAG 1 -- int10--------
    rs178501551,2
    ----24376462(+) TTCTGC/TTTTAT 2 K syn10--------
    rs3753208721,2
    ----7323844(+) ATCTC-/AAAAAAAA 1 -- ds50010--------
    rs3707052501,2
    ----24380475(+) GCCTGA/GTGTTC 1 -- int10--------
    rs1498962851,2
    ----24384230(+) GGCCCA/GTAGTG 2 T M mis11Minor allele frequency- G:0.00NA 3608
    rs3764609631,2
    ----24380168(+) TGCCAA/GAGTAT 1 -- int10--------
    rs3713285971,2
    ----24385430(+) TTCAGA/CTTTCC 1 -- us2k10--------
    rs1128674761,2
    ----24376556(+) CCACGT/CGCTGC 2 /H /R mis11Minor allele frequency- C:0.00CSA 1
    rs360748181,2
    ----24382458(+) GTGCT-/GGGGAT 1 -- int10--------
    rs3688883301,2
    ----24383815(+) GACTAC/TGGCGT 1 -- int10--------
    rs3768132271,2
    ----24377152(+) AGTGGC/GTGATC 1 -- int10--------
    rs3711385831,2
    ----24378894(+) GAATCC/GTTGAG 1 -- int10--------
    rs557191651,2
    ----24384049(+) GAAGTC/TCCCTA 1 -- int10--------
    rs3735424401,2
    ----24377184(+) CCTCCC/TGGTTC 1 -- int10--------
    rs11309901,2
    ----24384217(-) GAGCTC/GTACCT 2 L syn10--------
    rs3688280701,2
    ----24384276(+) CAGCAA/CACTCC 1 -- ut510--------
    rs3773425021,2
    ----24381688(+) CCTAGC/GGTCCC 1 -- int10--------
    rs3760063101,2
    ----24379584(+) TTTTT-/TTTTTTT 1 -- int10--------
    rs3719587511,2
    ----24383915(+) CCCGTC/GGTCTA 1 -- int10--------
    rs3697168611,2
    ----24385117(+) TTTATG/TAGATA 1 -- us2k10--------
    rs3754991801,2
    ----24383235(+) CTCTGA/TTAAAA 1 -- int10--------
    rs560236171,2
    ----24379486(+) TTTGCG/TCGTCA 2 S R mis10--------
    rs2017648031,2
    ----24376590(+) GCCTTC/TGAAGA 2 K E mis11Minor allele frequency- T:0.00EU 885
    rs3682942081,2
    ----24383343(+) TGCAGA/TGATTC 1 -- int10--------
    rs3703301231,2
    ----24381721(+) AGTCCC/TCGTCC 2 E G mis10--------
    rs41475821,2
    ----24384363(-) GCGTCC/TGTGCC 1 -- us2k10--------
    rs3721337361,2
    ----24381588(+) GATGCA/GGGCAC 1 -- int10--------
    rs711849371,2
    ----24379893(+) TTTTT-/TTTT  
      TTTTTT
    GGAGA
    1 -- int11Minor allele frequency- TTTTTTTTTT:0.00NA 2
    rs586352641,2
    ----24379591(+) TTTTT-/TTGATAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GSTT1 (24376133 - 24384680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GSTT1 (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421529CNV Deletion20811451
    esv2724041CNV Deletion23290073
    nsv436358CNV Deletion17901297
    dgv827e199CNV Deletion23128226
    nsv820435CNV Deletion20802225
    nsv914614CNV Loss21882294
    nsv829111CNV Loss20364138
    nsv438340CNV Loss16468122
    dgv752n67CNV Loss20364138
    nsv498985CNV Loss21111241

    Human Gene Mutation Database (HGMD): GSTT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTT1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600436    OMIM disorders: --

    Selected diseases for GSTT1 (see all 228):    
    About MalaCards
    asbestosis    oral cancer    senile cataract    cardia cancer
    laryngeal carcinoma    benzene toxicity    exfoliation syndrome    laryngitis
    leukoplakia    drug-induced hepatitis    oral submucous fibrosis    rosacea
    mutagen sensitivity    oral leukoplakia    laryngeal squamous cell carcinoma    oral cavity cancer
    lung cancer susceptibility    oligospermia    diabetic polyneuropathy    alcoholic pancreatitis

    1 disease from the University of Copenhagen DISEASES database for GSTT1:
    Cancer

    GSTT1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for GSTT1 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic susceptibility 71.8 16 10698723 (1), 10813720 (1), 11751440 (1), 19963114 (1) (see all 15)
    cancer 63 126 9298582 (6), 15165083 (3), 19270789 (3), 18392488 (3) (see all 86)
    blond hair 59 1 11352862 (1)
    chromosomal aberrations 56.9 26 20464961 (3), 9804932 (2), 9093388 (2), 10634136 (1) (see all 16)
    bladder cancer 56.9 84 9544433 (5), 9921921 (4), 15588859 (4), 18979064 (4) (see all 29)
    environmental carcinogenesis 55.9 2 9788723 (1), 18463401 (1)
    cancer lung 55.7 127 16228113 (6), 15105047 (5), 15246186 (5), 18415801 (5) (see all 51)
    smoking habit 48.8 1 18608187 (1)
    carcinoma squamous cell 44.6 20 17221058 (4), 14724908 (1), 15914211 (1), 9029171 (1) (see all 17)
    colorectal cancer 44 79 20061204 (7), 15770723 (4), 15932063 (4), 9829708 (4) (see all 28)

    Genetic Association Database (GAD): GSTT1
    Human Genome Epidemiology (HuGE) Navigator: GSTT1 (1267 documents)

    Export disorders for GSTT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTT1 gene, integrated from 10 sources (see all 1780):
    (articles sorted by number of sources associating them with GSTT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. (PubMed id 17381051)1, 4, 7, 9 Ouerhani S....ElgaaA^ed A.B. (Ann. Hum. Biol. 2006)
    2. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PubMed id 17372252)1, 4, 7, 9 Schwartzbaum J.A....Feychting M. (amp 2007)
    3. The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults. (PubMed id 17653748)1, 4, 7, 9 Gawecki W....Szyfter W. (Eur Arch Otorhinolaryngol 2007)
    4. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PubMed id 17333241)1, 4, 7, 9 JAPnsson L.S....JAPnsson B.A. (Int Arch Occup Environ Health 2007)
    5. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. (PubMed id 17617661)1, 4, 7 Moore L.E....Chow W.H. (Carcinogenesis 2007)
    6. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. (PubMed id 11081456)1, 4, 7 Peters U....Lamprecht-Dinnesen A. (Anticancer Drugs 2000)
    7. Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study. (PubMed id 11819818)1, 4, 9 Cai L....Zhang Z.F. (World J. Gastroenterol. 2001)
    8. [Genetic polymorphisms of NQO1, GSTT1, GSTM1 and susceptibility to chronic benzene poisoning]. (PubMed id 15748501)1, 4, 9 Chen Y....Wu C.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2005)
    9. GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans. (PubMed id 20036620)1, 4, 9 Kim S.H....Jee Y.K. (Tuberculosis (Edinb) 2010)
    10. [Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province]. (PubMed id 19799150)1, 4, 9 Li X.T....Zhan S.Y. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2952 HGNC: 4641 AceView: GSTT1 Ensembl:ENSG00000184674 euGenes: HUgn2952
    ECgene: GSTT1 Kegg: 2952 H-InvDB: GSTT1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSTT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTT1 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTT1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTT1 gene:
    Search GeneIP for patents involving GSTT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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