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Aliases for GSTT1 Gene

Aliases for GSTT1 Gene

  • Glutathione S-Transferase Theta 1 2 3
  • EC 2.5.1.18 4 63
  • Glutathione Transferase T1-1 4
  • GST Class-Theta-1 4

External Ids for GSTT1 Gene

Previous GeneCards Identifiers for GSTT1 Gene

  • GC22M021072
  • GC22M020995
  • GC22M022700
  • GC22M022706
  • GC22M024377
  • GC22M024341
  • GC22M007324
  • GC22M024378
  • GC22M024380
  • GC22M024506
  • GC22M024776
  • GC22M024952
  • GC22M025171

Summaries for GSTT1 Gene

Entrez Gene Summary for GSTT1 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT1 Gene

GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include larynx cancer and varicocele. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot for GSTT1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Gene Wiki entry for GSTT1 Gene

PharmGKB "VIP" Summary for GSTT1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT1 Gene

Genomics for GSTT1 Gene

Regulatory Elements for GSTT1 Gene

Transcription factor binding sites by QIAGEN in the GSTT1 gene promoter:

Genomic Location for GSTT1 Gene

Chromosome:
22
Start:
270,308 bp from pter
End:
278,486 bp from pter
Size:
8,179 bases
Orientation:
Minus strand

Genomic View for GSTT1 Gene

Genes around GSTT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GSTT1 Gene

Proteins for GSTT1 Gene

  • Protein details for GSTT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30711-GSTT1_HUMAN
    Recommended name:
    Glutathione S-transferase theta-1
    Protein Accession:
    P30711
    Secondary Accessions:
    • O00226
    • Q5TZY2
    • Q6IC69
    • Q969K8
    • Q96IY3

    Protein attributes for GSTT1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27335 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT1 Gene

    Alternative splice isoforms for GSTT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTT1 Gene

Proteomics data for GSTT1 Gene at MOPED

Selected DME Specific Peptides for GSTT1 Gene

Post-translational modifications for GSTT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for GSTT1 Gene

Gene Families for GSTT1 Gene

Suggested Antigen Peptide Sequences for GSTT1 Gene

Graphical View of Domain Structure for InterPro Entry

P30711

UniProtKB/Swiss-Prot:

GSTT1_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Theta family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT1: view

Function for GSTT1 Gene

Molecular function for GSTT1 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 1,theta class,deleted in bladder cancer
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Enzyme Numbers (IUBMB) for GSTT1 Gene

Gene Ontology (GO) - Molecular Function for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004602 glutathione peroxidase activity IDA 9307035
genes like me logo Genes that share ontologies with GSTT1: view
genes like me logo Genes that share phenotypes with GSTT1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTT1 Gene

Localization for GSTT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTT1 Gene COMPARTMENTS Subcellular localization image for GSTT1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GSTT1: view

Pathways & Interactions for GSTT1 Gene

genes like me logo Genes that share pathways with GSTT1: view

Interacting Proteins for GSTT1 Gene

Gene Ontology (GO) - Biological Process for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 9307035
GO:0098869 cellular oxidant detoxification IDA 9307035
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTT1: view

No data available for SIGNOR curated interactions for GSTT1 Gene

Drugs & Compounds for GSTT1 Gene

(32) Drugs for GSTT1 Gene - From: Novoseek, HMDB, PharmGKB, FDA Approved Drugs, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Glutathione Approved Nutra Target 0
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1322
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 1885
Etoposide Approved Pharma Enzyme, substrate Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1169

(90) Additional Compounds for GSTT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTT1: view

Transcripts for GSTT1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 Gene

No ASD Table

Relevant External Links for GSTT1 Gene

GeneLoc Exon Structure for
GSTT1
ECgene alternative splicing isoforms for
GSTT1

Expression for GSTT1 Gene

mRNA expression in normal human tissues for GSTT1 Gene

Protein differential expression in normal tissues from HIPED for GSTT1 Gene

This gene is overexpressed in Uterus (11.0) and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GSTT1 Gene



SOURCE GeneReport for Unigene cluster for GSTT1 Gene Hs.268573

mRNA Expression by UniProt/SwissProt for GSTT1 Gene

P30711-GSTT1_HUMAN
Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
genes like me logo Genes that share expression patterns with GSTT1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for GSTT1 Gene

Orthologs for GSTT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSTT1 Gene

Organism Taxonomy Gene Similarity Type Details
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.935 35
Species with no ortholog for GSTT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for GSTT1 Gene

Paralogs for GSTT1 Gene

genes like me logo Genes that share paralogs with GSTT1: view

No data available for Paralogs for GSTT1 Gene

Variants for GSTT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT1 Gene

P30711-GSTT1_HUMAN
The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.

Sequence variations from dbSNP and Humsavar for GSTT1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_014501 -
VAR_014502 -
VAR_014503 -
VAR_014504 -

Structural Variations from Database of Genomic Variants (DGV) for GSTT1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
dgv4911n71 CNV Loss 21882294
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
nsv9878 CNV Gain+Loss 18304495
nsv914614 CNV Loss 21882294
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294
dgv4913n71 CNV Gain 21882294
dgv827e199 CNV Deletion 23128226
nsv820435 CNV Deletion 20802225
nsv829111 CNV Loss 20364138
nsv914625 CNV Gain+Loss 21882294
dgv102e180 CNV Gain 20482838
esv33707 CNV Gain+Loss 17666407
nsv436358 CNV Deletion 17901297
nsv819129 CNV Gain 19587683
nsv498985 CNV Loss 21111241
dgv752n67 CNV Loss 20364138
esv2421529 CNV Deletion 20811451
nsv829114 CNV Gain+Loss 20364138
esv29978 CNV Gain 17803354
nsv514966 CNV Complex 21397061
esv29950 CNV Gain 18421352
nsv442793 CNV CNV 18776908
nsv433180 CNV Loss 18776910
nsv914628 CNV Loss 21882294
nsv829122 CNV Loss 20364138
dgv754n67 CNV Loss 20364138
nsv482075 CNV Loss 20164927
nsv438340 CNV Loss 16468122

Variation tolerance for GSTT1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTT1 Gene

HapMap Linkage Disequilibrium report
GSTT1
Human Gene Mutation Database (HGMD)
GSTT1

Disorders for GSTT1 Gene

MalaCards: The human disease database

(29) MalaCards diseases for GSTT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
larynx cancer
  • laryngeal neoplasms
varicocele
  • scrotal varices
multiple chemical sensitivity
  • 20th century disease
senile cataract
toxic encephalopathy
  • neurotoxicity
- elite association - COSMIC cancer census association via MalaCards
Search GSTT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTT1

Genetic Association Database (GAD)
GSTT1
Human Genome Epidemiology (HuGE) Navigator
GSTT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTT1
genes like me logo Genes that share disorders with GSTT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT1 Gene

Publications for GSTT1 Gene

  1. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PMID: 17333241) JAPnsson L.S. … JAPnsson B.A. (Int Arch Occup Environ Health 2007) 3 23 25 26
  2. Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study. (PMID: 11819818) Cai L. … Zhang Z.F. (World J. Gastroenterol. 2001) 3 23 48 67
  3. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum J.A. … Feychting M. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 25 26
  4. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. (PMID: 17617661) Moore L.E. … Chow W.H. (Carcinogenesis 2007) 3 25 26
  5. The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults. (PMID: 17653748) Gawecki W. … Szyfter W. (Eur Arch Otorhinolaryngol 2007) 3 25 26

Products for GSTT1 Gene

Sources for GSTT1 Gene

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