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Aliases for GSTT1 Gene

Aliases for GSTT1 Gene

  • Glutathione S-Transferase Theta 1 2 3
  • EC 2.5.1.18 4 61
  • Glutathione Transferase T1-1 4
  • GST Class-Theta-1 4

External Ids for GSTT1 Gene

Previous GeneCards Identifiers for GSTT1 Gene

  • GC22M021072
  • GC22M020995
  • GC22M022700
  • GC22M022706
  • GC22M024377
  • GC22M024341
  • GC22M007324
  • GC22M024378
  • GC22M024380
  • GC22M024506
  • GC22M024776
  • GC22M024952
  • GC22M025171

Summaries for GSTT1 Gene

Entrez Gene Summary for GSTT1 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT1 Gene

GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include Larynx Cancer and Mutagen Sensitivity. Among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Glutathione metabolism. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot for GSTT1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Gene Wiki entry for GSTT1 Gene

PharmGKB "VIP" Summary for GSTT1 Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT1 Gene

Genomics for GSTT1 Gene

Regulatory Elements for GSTT1 Gene


Transcription factor binding sites by QIAGEN in the GSTT1 gene promoter:

Genomic Location for GSTT1 Gene

Chromosome:
22
Start:
270,308 bp from pter
End:
278,486 bp from pter
Size:
8,179 bases
Orientation:
Minus strand

Genomic View for GSTT1 Gene

Genes around GSTT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GSTT1 Gene

Proteins for GSTT1 Gene

  • Protein details for GSTT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30711-GSTT1_HUMAN
    Recommended name:
    Glutathione S-transferase theta-1
    Protein Accession:
    P30711
    Secondary Accessions:
    • O00226
    • Q5TZY2
    • Q6IC69
    • Q969K8
    • Q96IY3

    Protein attributes for GSTT1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27335 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT1 Gene

    Alternative splice isoforms for GSTT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTT1 Gene

Selected DME Specific Peptides for GSTT1 Gene

P30711:
  • YIFAKKN
  • ARVDEYLAWQHT

Post-translational modifications for GSTT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GSTT1 Gene

Gene Families for GSTT1 Gene

Suggested Antigen Peptide Sequences for GSTT1 Gene

Graphical View of Domain Structure for InterPro Entry

P30711

UniProtKB/Swiss-Prot:

GSTT1_HUMAN :
  • Belongs to the GST superfamily. Theta family.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT1: view

Function for GSTT1 Gene

Molecular function for GSTT1 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 1,theta class,deleted in bladder cancer
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Enzyme Numbers (IUBMB) for GSTT1 Gene

Gene Ontology (GO) - Molecular Function for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004602 glutathione peroxidase activity IDA 9307035
GO:0005515 protein binding IPI 25910212
genes like me logo Genes that share ontologies with GSTT1: view
genes like me logo Genes that share phenotypes with GSTT1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTT1 Gene

Localization for GSTT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTT1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GSTT1: view

Pathways & Interactions for GSTT1 Gene

genes like me logo Genes that share pathways with GSTT1: view

Interacting Proteins for GSTT1 Gene

Gene Ontology (GO) - Biological Process for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 9307035
GO:0098869 cellular oxidant detoxification IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTT1: view

No data available for SIGNOR curated interactions for GSTT1 Gene

Drugs & Compounds for GSTT1 Gene

(34) Drugs for GSTT1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Glutathione Approved Nutra Target 0
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1460
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 2050
Etoposide Approved Pharma Enzyme, substrate Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1269

(89) Additional Compounds for GSTT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTT1: view

Transcripts for GSTT1 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 Gene

No ASD Table

Relevant External Links for GSTT1 Gene

GeneLoc Exon Structure for
GSTT1
ECgene alternative splicing isoforms for
GSTT1

Expression for GSTT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTT1 Gene

Protein differential expression in normal tissues from HIPED for GSTT1 Gene

This gene is overexpressed in Uterus (11.0) and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GSTT1 Gene:

GSTT1

SOURCE GeneReport for Unigene cluster for GSTT1 Gene:

Hs.268573

mRNA Expression by UniProt/SwissProt for GSTT1 Gene:

P30711-GSTT1_HUMAN
Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.

Evidence on tissue expression from TISSUES for GSTT1 Gene

  • Liver(4.6)
  • Lung(4.5)
  • Blood(2.9)
  • Kidney(2.4)
  • Skin(2.4)
  • Thyroid gland(2.3)
  • Intestine(2.2)
  • Urine(2.1)
  • Muscle(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with GSTT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTT1 Gene

Orthologs for GSTT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSTT1 Gene

Organism Taxonomy Gene Similarity Type Details
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.935 34
Species where no ortholog for GSTT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for GSTT1 Gene

Paralogs for GSTT1 Gene

genes like me logo Genes that share paralogs with GSTT1: view

No data available for Paralogs for GSTT1 Gene

Variants for GSTT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT1 Gene

GSTT1_HUMAN-P30711
The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.

Sequence variations from dbSNP and Humsavar for GSTT1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2234953 --
rs2266633 --
rs2266635 --
rs2266637 --

Variation tolerance for GSTT1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTT1 Gene

Human Gene Mutation Database (HGMD)
GSTT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTT1

No data available for Structural Variations from Database of Genomic Variants (DGV) for GSTT1 Gene

Disorders for GSTT1 Gene

MalaCards: The human disease database

(32) MalaCards diseases for GSTT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
larynx cancer
  • laryngeal benign neoplasm
mutagen sensitivity
senile cataract
asbestosis
  • idiopathic interstitial pneumonitis - from asbestos exposure
multiple chemical sensitivity
  • 20th century disease
- elite association - COSMIC cancer census association via MalaCards
Search GSTT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTT1

Genetic Association Database (GAD)
GSTT1
Human Genome Epidemiology (HuGE) Navigator
GSTT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTT1
genes like me logo Genes that share disorders with GSTT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT1 Gene

Publications for GSTT1 Gene

  1. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PMID: 17333241) JAPnsson L.S. … JAPnsson B.A. (Int Arch Occup Environ Health 2007) 3 22 25 46 64
  2. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PMID: 19430957) Rafiee L. … Saadat M. (Mol. Biol. Rep. 2010) 3 22 46 64
  3. GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis. (PMID: 19760040) Sergentanis T.N. … Economopoulos K.P. (Breast Cancer Res. Treat. 2010) 3 22 46 64
  4. Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents. (PMID: 20197727) Woo H.Y. … Lim S.W. (Korean J Lab Med 2010) 3 22 46 64
  5. Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. (PMID: 20303013) Cho H.J. … Kong S.Y. (Cancer Genet. Cytogenet. 2010) 3 22 46 64

Products for GSTT1 Gene

Sources for GSTT1 Gene

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