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GSTT1 Gene

protein-coding GIFtS: 69

GC22M022706

glutathione S-transferase theta 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 2.5.1.18 ^³

Descriptions
GST class-theta-1 ^³
Glutathione transferase T1-1 ^³
glutathione S-transferase theta 1 ^²

External Ids
HGNC: 4641¹
Entrez Gene: 2952²
UniProtKB: P30711³
Ensembl: ENSG00000184674⁷

Search outside databases for aliases for GSTT1 gene

Previous GC identifers: GC22M021072 GC22M020995 GC22M022700

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GSTT1:

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that

catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic

compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The

theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity

and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is

located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar

structure, being composed of five exons with identical exon/intron boundaries. [provided by

RefSeq]

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous

hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate

4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with

cumene hydroperoxide

Gene Wiki entry for GSTT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GSTT1 gene

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

GSTT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M022706: (about GC identifiers)

Start:	22,706,141 bp from pter
End:	22,714,271 bp from pter
Size:	8,131 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711 (See protein sequence)

Recommended Name: Glutathione S-transferase theta-1

Size: 240 amino acids; 27335 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2C3N (3D)

2C3Q (3D)

2C3T (3D)

Secondary accessions: O00226 Q5TZY2 Q969K8 Q96IY3

REFSEQ proteins: NP_000844.2

ENSEMBL proteins:

ENSP00000248935 ENSP00000372242

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Glutathione S Transferase theta 1 )
	Human Recombinant Proteins from Abnova (GSTT1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for GSTT1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GSTT1
	Sigma-Aldrich Antibodies for GSTT1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Glutathione S Transferase theta 1 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GSTT1)
	Novus Biologicals Antibodies for GSTT1

Assays for GSTT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P30711

ProtoNet protein and cluster: P30711

1 Blocks protein family: IPB004045 Glutathione S-transferase

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711

Similarity: Belongs to the GST superfamily. Theta family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSTT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GSTT1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000853

Applied Biosystems Silencer® siRNAs for GSTT1

Sigma-Aldrich siRNA for GSTT1

Sigma-Aldrich shRNA for GSTT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000853
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000853
untagged cDNA clone in CMV expression vector: NM_000853

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000853

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous

hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate

4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with

cumene hydroperoxide

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Enzyme Number (IUBMB): EC 2.5.1.18

Genatlas biochemistry entry for GSTT1:

glutathione-S-transferase 1,theta class,deleted in bladder cancer

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gstt1):

homeostasis/metabolism

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	TAS	8198545
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GSTT1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Xenobiotic Metabolism Signaling
LPS/IL-1 Mediated Inhibition of RXR Function
Aryl Hydrocarbon Receptor Signaling
Glutathione Metabolism
NRF2-mediated Oxidative Stress Response

GeneDecks GSTT1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GSTT1

5/73 Interacting proteins for GSTT1 (ENSP00000248935³) via UniProtKB, MINT, and/or STRING (see all 73 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP1A1	ENSP00000369050³	STRING (score=.996)
GSTM1	ENSP00000358838³	STRING (score=.995)
GSTP1	ENSP00000196968³	STRING (score=.993)
CYP1A2	ENSP00000342007³	STRING (score=.987)
GSTM2	ENSP00000358845³	STRING (score=.984)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GSTT1 available from Tocris Bioscience

Compound	Action	CAS number
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

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10/52 Novoseek chemical compound relationships for GSTT1 gene (see all 52 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	93.66	17	7788840 (1), 11553769 (1), 15382272 (1), 17284320 (1) (see all 17)
epoxide	78.45	29	11122850 (1), 12359356 (1), 12717779 (1), 16980312 (1) (see all 28)
diepoxybutane	71.77	70	7788840 (7), 8671741 (6), 15036125 (5), 12694746 (3) (see all 12)
1,3-butadiene	70.32	13	8524342 (1), 15036120 (1), 7606200 (1), 8980697 (1) (see all 12)
1-hydroxypyrene	67.43	5	11641039 (2), 11323399 (2), 11418090 (1)
mspi	61.26	13	10813720 (1), 15734083 (1), 11408954 (1), 17361553 (1) (see all 12)
s-phenylmercapturic acid	60.77	7	17885617 (3), 15533900 (2)
styrene oxide	60.28	14	9654239 (5), 12016165 (1), 12694745 (1), 18608187 (1)
n-(2-hydroxyethyl)valine	58.09	9	9826084 (3), 11352866 (2)
styrene	57.10	21	12016165 (5), 12717779 (2), 14751678 (2), 16424821 (2) (see all 11)

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10/12 PharmGKB drug compound relationships for GSTT1 gene (see all 12 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
asparaginase	CO	15713801
cytarabine	CO	15713801
daunorubicin	CO	15713801
etoposide	CO FA GN	8763337 11840286 10673738 9057653 15713801
fluorouracil	CO	12072547
mercaptopurine	CO	15713801
methotrexate	CO	15713801
prednisone	CO	15713801
tacrine	PD PK	10801254
teniposide	CO	10673738

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSTT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GSTT1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000853

Sigma-Aldrich siRNA for GSTT1

Sigma-Aldrich shRNA for GSTT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000853

REFSEQ mRNAs for GSTT1 gene:

NM_000853.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000853

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000853
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000853
                                 untagged cDNA clone in CMV expression vector: NM_000853

Additional cDNA sequence: BC050410.2

20 DOTS entries:

DT.95137787 DT.86837198 DT.120669464 DT.451653 DT.100711917 DT.99962693 DT.100716942 DT.100886963

DT.95154632 DT.100886973 DT.100724662 DT.91765800 DT.40116481 DT.443738 DT.97859048 DT.120669323

DT.91765808 DT.97790036 DT.120669449 DT.306274

24/235 AceView cDNA sequences (see all 235 ):

BQ127965 BU943479 T95880 BM765626 BF343733 AA171580 BM006030 CA313466

BE746521 AV648940 AA297181 BM766149 CR599021 BX401239 BI761235 BQ645697

BM821265 H55603 BM829777 AV648707 AV648681 T97888 AA297369 BM772021

highest scoring ESTs for GSTT1:

X79389 AA297369 AA300354 AF435971 AU100081 AV648625 AV648631 AV648681 AV648707 AV648716

Unigene Clusters for GSTT1:

Glutathione S-transferase theta 1

Hs.268573 [show with all ESTs], Hs.678440 [show with all ESTs]

Unigene Representative Sequences: CR749711, BC050410

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 (see all 10 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:													-		-				-		-
SP2:													-		-				-		-		-
SP3:													-		-		-		-		-
SP4:													-		-		-		-		-		-
SP5:													-		-				-		-		-		-

About this scheme

ECgene alternative splicing isoforms for GSTT1

2 Ensembl transcripts including schematic representations:

ENST00000248935 ENST00000382792

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GSTT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GSTT1

¹ / ² / ³

7 probe-sets matching GSTT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37222_at²^{, 3}	U95-A	1	1.00	1.00	0.83	1.51	X79389	1.00	1.00	1.00	1
375_at²^{, 3}	U95-A	1	0.75	1.00	0.85	1.29	Z84718	0.20	0.20	0.20	1
54188_i_at*²^{, 3}	U95-C	1	1.00	1.00	0.59	0.27	T70567	0.60	1.00	0.82	1
203815_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000853	0.60	1.00	0.82	1
232193_at*²^{, 3}	U133-B	1	1.00	1.00	--	--	AL359937	0.60	1.00	0.82	1
203815_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232193_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GSTT1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCAGGTCTG

SOURCE GeneReport for Unigene clusters: Hs.268573 Hs.678440
Expression variation in blood from EXPOLDB for GSTT1
UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at
low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from
epithelial cells of larger bronchioles

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GSTT1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GSTT1¹	--	glutathione S-transferase theta 1	89.03(n) 91.25(a)	477556 XM_534751.2 XP_534751.2
chimpanzee (Pan troglodytes)	GSTT1¹	--	glutathione S-transferase theta 1	99.17(n) 99.58(a)	470264 XM_001170293.1 XP_001170293.1
cow (Bos taurus)	GSTT1¹	--	glutathione S-transferase theta 1	87.5(n) 86.25(a)	517724 NM_001046232.1 NP_001039697.1
rat (Rattus norvegicus)	Gstt1¹	--	glutathione S-transferase theta 1	82.36(n) 80(a)	25260 NM_053293.2 NP_445745.1
mouse (Mus musculus)	Gstt1^{1, 5}	10 (40.70 cM)⁵	glutathione S-transferase, theta 1^{1, 5}	81.94(n)¹ 80.83(a)¹	14871¹ NM_008185.2¹ NP_032211.2¹ AA245192⁵ AI255817⁵ (see all 11)

About this table Species with no ortholog for GSTT1

ENSEMBL Gene Tree for GSTT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GSTT1 gene

GSTTP1² GSTT2B² ENSG00000184490² ENSG00000206090² GSTT2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711

Polymorphism: The GSTT1 gene is absent from 38% of the population. The presence or absence of the

GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes

respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane

10/54 NCBI SNPs in GSTT1 are shown (see all 54 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 16)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6004035^1,2	C,F,H	22715247(+)	`aggtgC/Tgcaca`	1	--	ng3¹		2		EA	150
	rs4630^1,2	A,C,F	22706322(-)	`CTTGCT/CTAAGA`	1	--	ut3¹ ese³		12		NA MN CSAM EA	878
	rs6519497^1,2	A,C	22714287(+)	`AGTGCC/GAGGAC`	1	--	ng3¹		0	--	--	--	--
	rs2266633^1,2	F,H	22706929(-)	`AGTTGG/AATGTG`	1	N/D	mis¹		3		NA MN EU	364
--	rs5996657^1,2	A,C	22715105(+)	`CAACTA/Gtttta`	1	--	ng3¹		0	--	--	--	--
--	rs2844009^1,2	A,C	22715697(+)	`aacccC/Tatctc`	1	--	ng3¹		0	--	--	--	--
--	rs2739345^1,2	A,C	22705989(+)	`ccaccA/Gcacgc`	1	--	ng5¹		0	--	--	--	--
	rs2266637^1,2	C,F	22706845(-)	`ACCTCG/ATAGCC`	1	I/V	mis¹		7		NA MN EU EA WA	744
--	rs2739346^1,2	C	22705993(+)	`cgcacC/Gcggcc`	1	--	ng5¹		0	--	--	--	--
	rs17856199^1,2	H	22711766(+)	`GGGCAA/CAGGCA`	1	F/C	mis¹		4		EU EA WA	368

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HapMap Linkage Disequilibrium images for GSTT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600436

10/89 Novoseek disease relationships for GSTT1 gene (see all 89 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
genetic susceptibility	71.31	14	10698723 (1), 10813720 (1), 11751440 (1), 11819818 (1) (see all 13)
cancer	62.74	120	9298582 (6), 15165083 (3), 19270789 (3), 18392488 (3) (see all 81)
blond hair	60.95	1	11352862 (1)
bladder cancer	57.99	83	9544433 (5), 9921921 (4), 15588859 (4), 18979064 (4) (see all 28)
environmental carcinogenesis	57.75	2	9788723 (1), 18463401 (1)
cancer lung	56.53	117	16228113 (6), 15105047 (5), 15246186 (5), 18415801 (5) (see all 46)
chromosomal aberrations	56.36	20	9804932 (2), 9093388 (2), 10634136 (1), 10708971 (1) (see all 15)
smoking habit	50.19	1	18608187 (1)
adult brain tumor	46.45	1	17372252 (1)
carcinoma squamous cell	45.39	20	17221058 (4), 14724908 (1), 15914211 (1), 9029171 (1) (see all 17)

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7 PharmGKB disease relationships for GSTT1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Alzheimer's dementia	PD PK	10801254
Colorectal Neoplasms	CO	11773864 12072547
Labor, Premature	GN	15475730
Leukemia, Lymphocytic, Acute	CO	9057653
Leukemia, Lymphocytic, Acute, L1	CO	10673738 15713801
Leukemia, Myelocytic, Acute	CO GN	11840286 10673738
Neoplasms, Second Primary	CO	10673738

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Human Gene Mutation Database: GSTT1
Genetic Association Database: GSTT1
Human Genome Epidemiology Navigator: GSTT1 (946 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Genetic Polymorphisms in Xenobiotic-Metabolising Enzymes and Their Association With Colorectal Cancer: Presented at AACR-NCI-EORTC

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1218 PubMed articles for GSTT1 gene (see all 1218 ):

Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy. (PubMed id 11840286)^{1, 3, 6, 7} Naoe T....Ohno R. (2002)
Maternal/newborn GSTT1 null genotype contributes to risk of preterm, low birthweight infants. (PubMed id 15475730)^{1, 3, 7} Nukui T....Romkes M. (2004)
Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposis. (PubMed id 11773864)^{1, 3, 7} Lamberti C....Kruse R. (2002)
[Genetic polymorphisms of NQO1, GSTT1, STM1 and susceptibility to chronic benzene poisoning.] (PubMed id 15748501)^{1, 3, 6} Chen Y....Wu C.L. (2005)
Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes. (PubMed id 15036125)^{1, 3, 6} Schlade-Bartusiak K....Sasiadek M. (2004)
[Associations of genetic polymorphisms in the EPHX1 gene and the GSTT1 gene with low birth weight in neonates] (PubMed id 15719050)^{1, 3, 6} Liang H.Y....Wu B.Y. (2005)
[Genetic polymorphisms of the CYP450 1A1, CYP450 2E1, GSTM1, GSTT1, and GSTP1 in Korean] (PubMed id 15952134)^{1, 3, 6} Xu Q.S....Lee K.H. (2005)
[Associations between genetic polymorphisms of glutathione S-transferase M1 and T1, smoking and susceptibility to colorectal cancer: a case-control study.] (PubMed id 15777499)^{1, 3, 6} Chen K....Zhou H.G. (2004)
Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PubMed id 15338373)^{1, 3, 6} Schneider A....Whitcomb D.C. (2004)
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. (PubMed id 12460800)^{1, 3, 6} Wan J....Hu G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2952	HGNC: 4641	AceView: GSTT1	Ensembl:ENSG00000184674	euGenes: HUgn2952
ECgene: GSTT1	H-InvDB: GSTT1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GSTT1	Genetics and Cytogenetics in Oncology and Haematology
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTT1

Licensable Technologies for GSTT1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GSTT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GSTT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GSTT1		Antibodies for GSTT1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GSTT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GSTT1)
	Antibodies (GSTT1)
	Chimera RNAi (GSTT1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Glutathione S Transferase theta 1 )
	Antibodies (Glutathione S Transferase theta 1 )

Search OriGene for GSTT1

Tocris compounds for GSTT1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GSTT1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GSTT1 Gene at Home site.
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GSTT1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GSTT1

Summaries
for GSTT1

Genomic Location
for GSTT1

Proteins
for GSTT1

Protein Domains/
Families
for GSTT1

Gene Function
for GSTT1

Pathways & Interactions
for GSTT1

Drugs & Compounds
for GSTT1

Transcripts
for GSTT1

Expression
for GSTT1

Orthologs
for GSTT1

Paralogs
for GSTT1

SNPs/Variants
for GSTT1

Disorders & Mutations
for GSTT1

Medical News
for GSTT1

Publications
for GSTT1

Search for GSTT1

Genome Databases showing GSTT1

Other Databases showing GSTT1

Specialized Databases showing GSTT1

Licensable Technologies
for GSTT1

Services
for GSTT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GSTT1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GSTT1

Summariesfor GSTT1

Genomic Locationfor GSTT1

Proteinsfor GSTT1

Protein Domains/Familiesfor GSTT1

Gene Functionfor GSTT1

Pathways & Interactionsfor GSTT1

Drugs & Compoundsfor GSTT1

Transcriptsfor GSTT1

Expression for GSTT1

Orthologsfor GSTT1

Paralogsfor GSTT1

SNPs/Variantsfor GSTT1

Disorders & Mutationsfor GSTT1

Medical Newsfor GSTT1

Publicationsfor GSTT1

Search for GSTT1

Genome Databases showing GSTT1

Other Databases showing GSTT1

Specialized Databases showing GSTT1

Licensable Technologiesfor GSTT1

Servicesfor GSTT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GSTT1

Summaries
for GSTT1

Genomic Location
for GSTT1

Proteins
for GSTT1

Protein Domains/
Families
for GSTT1

Gene Function
for GSTT1

Pathways & Interactions
for GSTT1

Drugs & Compounds
for GSTT1

Transcripts
for GSTT1

Expression
for GSTT1

Orthologs
for GSTT1

Paralogs
for GSTT1

SNPs/Variants
for GSTT1

Disorders & Mutations
for GSTT1

Medical News
for GSTT1

Publications
for GSTT1

Licensable Technologies
for GSTT1

Services
for GSTT1