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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTT1 Gene

protein-coding   GIFtS: 69
GCID: GC22M024952

Glutathione S-Transferase Theta 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione S-Transferase Theta 11 2
Glutathione Transferase T1-12 3
GST Class-Theta-12 3
EC 2.5.1.183 8
Glutathione S-Transferase Theta-12

External Ids:    HGNC: 46411   Entrez Gene: 29522   Ensembl: ENSG000001846747   OMIM: 6004365   UniProtKB: P307113   

Export aliases for GSTT1 gene to outside databases

Previous GC identifers: GC22M021072 GC22M020995 GC22M022700 GC22M022706 GC22M024377 GC22M024341 GC22M007324 GC22M024378 GC22M024380 GC22M024506 GC22M024776


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTT1 Gene:
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the
conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be
divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The
GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in
human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2
genes have a similar structure, being composed of five exons with identical exon/intron boundaries. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GSTT1 Gene: 
GSTT1 (glutathione S-transferase theta 1) is a protein-coding gene. Diseases associated with GSTT1 include asbestosis, and oral cancer, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and
4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide

Gene Wiki entry for GSTT1 Gene

PharmGKB "VIP" summary for GSTT1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTT1 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

GSTT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTT1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M024952:  view genomic region     (about GC identifiers)

Start:
24,376,133 bp from pter      End:
24,384,680 bp from pter
Size:
8,548 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711 (See protein sequence)
Recommended Name: Glutathione S-transferase theta-1  
Size: 240 amino acids; 27335 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for GSTT1:
2C3N (3D)        2C3Q (3D)        2C3T (3D)    
Secondary accessions: O00226 Q5TZY2 Q969K8 Q96IY3

Explore the universe of human proteins at neXtProt for GSTT1: NX_P30711

Explore proteomics data for GSTT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30711

  • 2 DME Specific Peptides for GSTT1 (P30711)
     YIFAKKN  ARVDEYLAWQHT 

    GSTT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSTT1 Protein Expression
    REFSEQ proteins: NP_000844.2  
    ENSEMBL proteins: 
     ENSP00000389481   ENSP00000406746   ENSP00000248935   ENSP00000400343   ENSP00000414223  
     ENSP00000396227   ENSP00000406003   ENSP00000399037   ENSP00000397362   ENSP00000401632  
    Reactome Protein details: P30711
    Human Recombinant Protein Products for GSTT1: 
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    OriGene Protein Over-expression Lysate for GSTT1
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    Novus Biologicals GSTT1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GSTT1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    GSTT1 for ontologies           About GeneDecksing



    GSTT1 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P30711

    ProtoNet protein and cluster: P30711

    1 Blocks protein domain: IPB004045 Glutathione S-transferase

    UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
    Similarity: Belongs to the GST superfamily. Theta family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTT1_HUMAN, P30711
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and
    4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTT1:
    glutathione-S-transferase 1,theta class,deleted in bladder cancer

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA--
    GO:0004602glutathione peroxidase activity IDA9307035
    GO:0005515protein binding ----
    GO:0016740transferase activity ----
         
    GSTT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTT1:
     Increased viability after born 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gstt1):
     homeostasis/metabolism 

    GSTT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gstt1tm1Kfuj for GSTT1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSTT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSTT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTT1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTT1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GSTT1
    SwitchGear 3'UTR luciferase reporter plasmidGSTT1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: GSTT1 (NM_000853)
    Sino Biological Human cDNA Clone for GSTT1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT1
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                         Customized lentivirus expression plasmids for stable overexpression of GSTT1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GSTT1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione metabolism0.45
    Glutathione metabolism0.67
    glutathione-mediated detoxification I0.42
    Glutathione conjugation0.60
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    4Metabolism
    Metabolism0.40
    5Naphthalene metabolism
    Naphthalene metabolism0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for GSTT1
        Naphthalene metabolism
    Glutathione metabolism


    2 GeneGo (Thomson Reuters) Pathways for GSTT1
        Naphthalene metabolism
    Glutathione metabolism

    4 BioSystems Pathways for GSTT1
        Aflatoxin B1 metabolism
    glutathione-mediated detoxification I
    Glutathione metabolism
    metapathway biotransformation


    4        Reactome Pathways for GSTT1
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation

    2 PharmGKB Pathways for GSTT1
        Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    4         Kegg Pathways  (Kegg details for GSTT1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GSTT1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GSTT1 (ENSP000004016324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ensp: ENSP000002489354STRING: ensp: ENSP00000248935
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0014070response to organic cyclic compound IEA--
    GO:0042493response to drug IEA--
    GO:0044281small molecule metabolic process TAS--

    GSTT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GSTT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for GSTT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSTT1

    10/13 HMDB Compounds for GSTT1 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    ChlorineCl2 (see all 13)16887-00-6--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--

    5 DrugBank Compounds for GSTT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17372252 17381051 17653748 17617661 17333241
    CisplatinCDDP (see all 7)15663-27-1enzymesubstrate11081456
    EtoposideEPEG (see all 4)33419-42-0enzymesubstrate1315544
    CarboplatinCBDCA (see all 2)41575-94-4enzymesubstrate--
    OxaliplatinDiaminocyclohexane Oxalatoplatinum (see all 4)61825-94-3enzymesubstrate--

    10/68 Novoseek inferred chemical compound relationships for GSTT1 gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 94.3 19 7788840 (1), 19640174 (1), 11553769 (1), 15382272 (1) (see all 19)
    epoxide 76.9 29 11122850 (1), 12359356 (1), 12717779 (1), 16980312 (1) (see all 28)
    diepoxybutane 70.3 70 7788840 (7), 8671741 (6), 15036125 (5), 12694746 (3) (see all 12)
    1,3-butadiene 68.6 13 8524342 (1), 15036120 (1), 7606200 (1), 8980697 (1) (see all 12)
    1-hydroxypyrene 65.6 5 11641039 (2), 11323399 (2), 11418090 (1)
    s-phenylmercapturic acid 63.6 9 17885617 (3), 15533900 (2), 20100551 (1)
    mspi 62.7 14 10813720 (1), 15734083 (1), 19963114 (1), 11408954 (1) (see all 13)
    styrene oxide 58.4 14 9654239 (5), 12016165 (1), 12694745 (1), 18608187 (1)
    n-(2-hydroxyethyl)valine 56.8 9 9826084 (3), 11352866 (2)
    styrene 54.8 21 12016165 (5), 12717779 (2), 14751678 (2), 16424821 (2) (see all 11)

    2 PharmGKB related drug/compound annotations for GSTT1 gene    About this table
    Drug/compound PharmGKB Annotation
    Drugs For Treatment Of TuberculosisCA  
    isoniazidCA  

    Search CenterWatch for drugs/clinical trials and news about GSTT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSTT1 gene: 
    NM_000853.2  

    Unigene Clusters for GSTT1:

    Glutathione S-transferase theta 1
    Hs.268573  [show with all ESTs], Hs.738514
    Unigene Representative Sequences: CR749711, BC050410
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436103 ENST00000417831 ENST00000248935(uc002zze.4 uc010gug.3 uc011ajl.2 uc010guh.3)
    ENST00000426209 ENST00000458231 ENST00000417489 ENST00000417870 ENST00000418883
    ENST00000480898 ENST00000428175 ENST00000447865 ENST00000486544(uc010gui.1)
    ENST00000439996
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: GSTT1 (NM_000853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTT1
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                         Customized lentivirus expression plasmids for stable overexpression of GSTT1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTT1

    Additional mRNA sequence: BC050410.2 

    20 DOTS entries:

    DT.86837198  DT.95137787  DT.120669464  DT.451653  DT.100711917  DT.100886963  DT.95154632  DT.100716942 
    DT.100886973  DT.99962693  DT.100724662  DT.91765800  DT.40116481  DT.97859048  DT.120669323  DT.97790036 
    DT.306274  DT.443738  DT.91765808  DT.120669449 

    24/235 AceView cDNA sequences (see all 235):

    CR597354 H55603 AV648707 BM829777 BM830104 BM851576 CR602213 AV648681 
    CR622903 BX401239 AA297369 BQ645697 BM765626 AA171580 AV648940 BE746521 
    CA313466 BI761235 BM821265 BQ050734 T95880 H55601 BM772021 AV648716 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                      -     -           -     -                                                   
    SP2:                                      -     -           -     -     -                                             
    SP3:                                      -     -     -     -     -                                                   
    SP4:                                      -     -     -     -     -     -                                             
    SP5:                                      -     -           -     -     -     -                                       


    ECgene alternative splicing isoforms for GSTT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTT1 expression in normal human tissues (normalized intensities)      GSTT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGGTCTG
    GSTT1 Expression
    About this image


    GSTT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Smooth Muscle (Muscoskeletal System)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Fibroblast
             Detroit 551
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor

    See GSTT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSTT1

    SOURCE GeneReport for Unigene clusters: Hs.268573 Hs.738514

    UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
    Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in
    Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger
    bronchioles

        SABiosciences Expression via Pathway-Focused PCR Arrays including GSTT1: 
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              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GSTT1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstt11 , 5 glutathione S-transferase, theta 11, 5 82.5(n)1
    81.67(a)1
      10 (38.58 cM)5
    148711  NM_008185.31  NP_032211.31 
     757838135 
    chicken
    (Gallus gallus)
    Aves GSTT11 glutathione S-transferase theta-1-like 65.75(n)
    60.73(a)
      769847  XM_001231970.2  XP_001231971.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    56(a)
    47(a)
    possible ortholog
    many → 1
    GL344539.1(13835-19538)
    GL344539.1(28836-32313)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1376958112   -- 75.43(n)    137695811 
    zebrafish
    (Danio rerio)
    Actinopterygii gstt1a1 glutathione S-transferase theta 1a 60.43(n)
    53.91(a)
      563972  XM_687335.4  XP_692427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16811 CG1681 51.42(n)
    39.2(a)
      32299  NM_132658.1  NP_572886.2 


    ENSEMBL Gene Tree for GSTT1 (if available)
    TreeFam Gene Tree for GSTT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTT1 gene
    GSTT2B2  GSTT22  
    5 SIMAP similar genes for GSTT1 using alignment to 12 protein entries:     GSTT1_HUMAN (see all proteins):
    CNOT2    GSTT4    GSTT2    GSTT2B    Em

    GSTT1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for GSTT1 (see all 9)
    PGOHUM00000259693 PGOHUM00000259694 PGOHUM00000259695 PGOHUM00000246284 PGOHUM00000259696


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: GSTT1_HUMAN, P30711
    Polymorphism: The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is
    coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype
    can catalyze the glutathione conjugation of dichloromethane


    10/166 SNPs in GSTT1 are shown (see all 166)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783412681,2
    C--7323843(+) TATCTA/CAAAAA 1 -- ds50010--------
    rs1929208551,2
    --24375942(+) GATCCA/CCCTGC 1 -- ds50010--------
    rs27393451,2
    C,A,H--24375989(+) ccaccA/Gcacgc 1 -- ds50012Minor allele frequency- G:0.04NA 122
    rs27393461,2
    C,H--24375993(+) cgcacC/Gcggcc 1 -- ds50014Minor allele frequency- G:0.04WA NA 126
    rs1464601281,2
    --24376208(+) TAAAGG/TACACA 1 -- ut310--------
    rs46301,2
    C,F,A--24376322(-) CTTGCT/CTAAGA 1 -- ut31 ese318Minor allele frequency- C:0.24NA MN EA WA 1118
    rs1430795601,2
    F--24376423(+) CCAGCT/CCACCG 2 /* /W --1Minor allele frequency- C:0.00NA 3324
    rs1854991981,2
    --24376428(+) TCACCA/GGATCA 2 R W mis10--------
    rs763234591,2
    C--24376534(+) AGGTCA/CTCCCC 2 E D mis10--------
    rs773009081,2
    C--24376536(+) GTCCTC/TCCCCA 2 K E mis10--------

    HapMap Linkage Disequilibrium report for GSTT1 (24376133 - 24384680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/42 variations for GSTT1 (see all 42):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421529CNV Deletion20811451
    esv2724041CNV Deletion23290073
    nsv436358CNV Deletion17901297
    dgv827e199CNV Deletion23128226
    nsv820435CNV Deletion20802225
    nsv914614CNV Loss21882294
    nsv829111CNV Loss20364138
    nsv438340CNV Loss16468122
    dgv752n67CNV Loss20364138
    nsv498985CNV Loss21111241


    Human Gene Mutation Database (HGMD): GSTT1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for GSTT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600436    OMIM disorders: --

    20/226 diseases for GSTT1 (see all 226):    About MalaCards
    asbestosis    oral cancer    senile cataract    laryngitis
    cardia cancer    laryngeal carcinoma    leukoplakia    drug-induced hepatitis
    exfoliation syndrome    oral submucous fibrosis    oral leukoplakia    rosacea
    mutagen sensitivity    oligospermia    laryngeal squamous cell carcinoma    oral cavity cancer
    diabetic polyneuropathy    bladder cancer susceptibility    hepatocellular adenoma    familial prostate cancer

    1 disease from the University of Copenhagen DISEASES database for GSTT1:
    Cancer

    GSTT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/89 Novoseek inferred disease relationships for GSTT1 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic susceptibility 71.8 16 10698723 (1), 10813720 (1), 11751440 (1), 19963114 (1) (see all 15)
    cancer 63 126 9298582 (6), 15165083 (3), 19270789 (3), 18392488 (3) (see all 86)
    blond hair 59 1 11352862 (1)
    chromosomal aberrations 56.9 26 20464961 (3), 9804932 (2), 9093388 (2), 10634136 (1) (see all 16)
    bladder cancer 56.9 84 9544433 (5), 9921921 (4), 15588859 (4), 18979064 (4) (see all 29)
    environmental carcinogenesis 55.9 2 9788723 (1), 18463401 (1)
    cancer lung 55.7 127 16228113 (6), 15105047 (5), 15246186 (5), 18415801 (5) (see all 51)
    smoking habit 48.8 1 18608187 (1)
    carcinoma squamous cell 44.6 20 17221058 (4), 14724908 (1), 15914211 (1), 9029171 (1) (see all 17)
    colorectal cancer 44 79 20061204 (7), 15770723 (4), 15932063 (4), 9829708 (4) (see all 28)

    Genetic Association Database (GAD): GSTT1
    Human Genome Epidemiology (HuGE) Navigator: GSTT1 (1267 documents)

    Export disorders for GSTT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTT1 gene, integrated from 9 sources (see all 1734):
    (articles sorted by number of sources associating them with GSTT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. (PubMed id 17381051)1, 4, 7, 9 Ouerhani S....Elgaaied A.B. (2006)
    2. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PubMed id 17372252)1, 4, 7, 9 Schwartzbaum J.A....Feychting M. (2007)
    3. The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults. (PubMed id 17653748)1, 4, 7, 9 Gawecki W....Szyfter W. (2007)
    4. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PubMed id 17333241)1, 4, 7, 9 Jonsson L.S....Jonsson B.A. (2007)
    5. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. (PubMed id 17617661)1, 4, 7 Moore L.E....Chow W.H. (2007)
    6. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. (PubMed id 11081456)1, 4, 7 Peters U....Lamprecht-Dinnesen A. (2000)
    7. Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study. (PubMed id 11819818)1, 4, 9 Cai L....Zhang Z.F. (2001)
    8. [Genetic polymorphisms of NQO1, GSTT1, STM1 and susceptibility to chronic benzene poisoning.] (PubMed id 15748501)1, 4, 9 Chen Y....Wu C.L. (2005)
    9. GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans. (PubMed id 20036620)1, 4, 9 Kim S.H....Jee Y.K. (2010)
    10. [Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-p ositive pulmonary tuberculosis cases of Jilin province] (PubMed id 19799150)1, 4, 9 Li X.T....Zhan S.Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2952 HGNC: 4641 AceView: GSTT1 Ensembl:ENSG00000184674 euGenes: HUgn2952
    ECgene: GSTT1 Kegg: 2952 H-InvDB: GSTT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTT1 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTT1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSTT1 gene:
    Search GeneIP for patents involving GSTT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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