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Aliases for GSTT1 Gene

Aliases for GSTT1 Gene

  • Glutathione S-Transferase Theta 1 2 3
  • EC 2.5.1.18 4 63
  • Glutathione Transferase T1-1 4
  • GST Class-Theta-1 4

External Ids for GSTT1 Gene

Summaries for GSTT1 Gene

Entrez Gene Summary for GSTT1 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. GSTT1 and GSTT2 share 55% amino acid sequence identity and both may play an important role in human carcinogenesis. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. This GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes, which are also located on chromosome 22, have been identified. [provided by RefSeq, Jun 2014]

GeneCards Summary for GSTT1 Gene

GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include asbestosis and laryngeal carcinoma. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot for GSTT1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Gene Wiki entry for GSTT1 Gene

PharmGKB "VIP" Summary for GSTT1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT1 Gene

Genomics for GSTT1 Gene

Genomic Location for GSTT1 Gene

Start:
270,314 bp from pter
End:
278,459 bp from pter
Size:
8,146 bases
Orientation:
Minus strand

Genomic View for GSTT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for GSTT1 Gene

Regulatory Elements for GSTT1 Gene

Transcription factor binding sites by QIAGEN in the GSTT1 gene promoter:

Proteins for GSTT1 Gene

  • Protein details for GSTT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30711-GSTT1_HUMAN
    Recommended name:
    Glutathione S-transferase theta-1
    Protein Accession:
    P30711
    Secondary Accessions:
    • O00226
    • Q5TZY2
    • Q6IC69
    • Q969K8
    • Q96IY3

    Protein attributes for GSTT1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27335 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT1 Gene

    Alternative splice isoforms for GSTT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTT1 Gene

Proteomics data for GSTT1 Gene at MOPED

Selected DME Specific Peptides for GSTT1 Gene

Post-translational modifications for GSTT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT1 Gene

Domains for GSTT1 Gene

Gene Families for GSTT1 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

Suggested Antigen Peptide Sequences for GSTT1 Gene

Graphical View of Domain Structure for InterPro Entry

P30711

UniProtKB/Swiss-Prot:

GSTT1_HUMAN
Domain:
  • Contains 1 GST C-terminal domain.:
    • P30711
  • Contains 1 GST N-terminal domain.:
    • P30711
Family:
  • Belongs to the GST superfamily. Theta family.:
    • P30711
genes like me logo Genes that share domains with GSTT1: view

Function for GSTT1 Gene

Molecular function for GSTT1 Gene

GENATLAS Biochemistry: glutathione-S-transferase 1,theta class,deleted in bladder cancer
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Enzyme Numbers (IUBMB) for GSTT1 Gene

Gene Ontology (GO) - Molecular Function for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 20097269
GO:0004602 glutathione peroxidase activity IDA 9307035
genes like me logo Genes that share ontologies with GSTT1: view

Phenotypes for GSTT1 Gene

genes like me logo Genes that share phenotypes with GSTT1: view

Animal Models for GSTT1 Gene

MGI Knock Outs for GSTT1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GSTT1 Gene

Localization for GSTT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTT1 Gene COMPARTMENTS Subcellular localization image for GSTT1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GSTT1: view

Pathways for GSTT1 Gene

genes like me logo Genes that share pathways with GSTT1: view

Interacting Proteins for GSTT1 Gene

Gene Ontology (GO) - Biological Process for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 20097269
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IDA 9307035
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTT1: view

Compounds for GSTT1 Gene

(13) HMDB Compounds for GSTT1 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Chlorine
  • Cl2
16887-00-6

(5) Drugbank Compounds for GSTT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Carboplatin
  • CBDCA
41575-94-4 enzyme substrate
Cisplatin
  • CDDP
15663-27-1 enzyme substrate
Etoposide
  • EPEG
33419-42-0 enzyme substrate
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target
Oxaliplatin
  • Diaminocyclohexane Oxalatoplatinum
61825-94-3 enzyme substrate

(68) Novoseek inferred chemical compound relationships for GSTT1 Gene

Compound -log(P) Hits PubMed IDs
gsts 94.3 19
epoxide 76.9 28
diepoxybutane 70.3 32
1,3-butadiene 68.6 12
1-hydroxypyrene 65.6 5

(8) PharmGKB related drug/compound annotations for GSTT1 Gene

genes like me logo Genes that share compounds with GSTT1: view

Transcripts for GSTT1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 Gene

No ASD Table

Relevant External Links for GSTT1 Gene

GeneLoc Exon Structure for
GSTT1
ECgene alternative splicing isoforms for
GSTT1

Expression for GSTT1 Gene

mRNA expression in normal human tissues for GSTT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GSTT1 Gene

SOURCE GeneReport for Unigene cluster for GSTT1 Gene Hs.268573

mRNA Expression by UniProt/SwissProt for GSTT1 Gene

P30711-GSTT1_HUMAN
Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
genes like me logo Genes that share expressions with GSTT1: view

No data available for mRNA differential expression in normal tissues for GSTT1 Gene

Orthologs for GSTT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSTT1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gstt1 16
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.935 35
Species with no ortholog for GSTT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for GSTT1 Gene

Paralogs for GSTT1 Gene

genes like me logo Genes that share paralogs with GSTT1: view

No data available for Paralogs for GSTT1 Gene

Variants for GSTT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT1 Gene

P30711-GSTT1_HUMAN
The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane

Sequence variations from dbSNP and Humsavar for GSTT1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
VAR_014501 -
VAR_014502 -
VAR_014503 -
VAR_014504 -

Structural Variations from Database of Genomic Variants (DGV) for GSTT1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
dgv4911n71 CNV Loss 21882294
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
nsv9878 CNV Gain+Loss 18304495
nsv914614 CNV Loss 21882294
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294
dgv4913n71 CNV Gain 21882294
dgv827e199 CNV Deletion 23128226
nsv820435 CNV Deletion 20802225
nsv829111 CNV Loss 20364138
nsv914625 CNV Gain+Loss 21882294
dgv102e180 CNV Gain 20482838
esv33707 CNV Gain+Loss 17666407
nsv436358 CNV Deletion 17901297
nsv819129 CNV Gain 19587683
nsv498985 CNV Loss 21111241
dgv752n67 CNV Loss 20364138
esv2421529 CNV Deletion 20811451
nsv829114 CNV Gain+Loss 20364138
esv29978 CNV Gain 17803354
nsv514966 CNV Complex 21397061
esv29950 CNV Gain 18421352
nsv442793 CNV CNV 18776908
nsv433180 CNV Loss 18776910
nsv914628 CNV Loss 21882294
nsv829122 CNV Loss 20364138
dgv754n67 CNV Loss 20364138
nsv482075 CNV Loss 20164927
nsv438340 CNV Loss 16468122

Relevant External Links for GSTT1 Gene

HapMap Linkage Disequilibrium report
GSTT1
Human Gene Mutation Database (HGMD)
GSTT1

Disorders for GSTT1 Gene

(1) University of Copenhagen DISEASES for GSTT1 Gene

(89) Novoseek inferred disease relationships for GSTT1 Gene

Disease -log(P) Hits PubMed IDs
genetic susceptibility 71.8 15
cancer 63 108
blond hair 59 1
chromosomal aberrations 56.9 20
bladder cancer 56.9 67

Relevant External Links for GSTT1

Genetic Association Database (GAD)
GSTT1
Human Genome Epidemiology (HuGE) Navigator
GSTT1
genes like me logo Genes that share disorders with GSTT1: view

No data available for UniProtKB/Swiss-Prot for GSTT1 Gene

Publications for GSTT1 Gene

  1. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PMID: 17333241) JAPnsson L.S. … JAPnsson B.A. (Int Arch Occup Environ Health 2007) 3 23 25 48
  2. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum J.A. … Feychting M. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 23 25 48
  3. The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. (PMID: 17381051) Ouerhani S. … ElgaaA^ed A.B. (Ann. Hum. Biol. 2006) 3 23 25 48
  4. The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults. (PMID: 17653748) Gawecki W. … Szyfter W. (Eur Arch Otorhinolaryngol 2007) 3 23 25 48
  5. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme. (PMID: 9434735) Jemth P. … Mannervik B. (Arch. Biochem. Biophys. 1997) 3 4 23

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