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Aliases for GSTP1 Gene

Aliases for GSTP1 Gene

  • Glutathione S-Transferase Pi 1 2 3 5
  • GST Class-Pi 3 4
  • EC 2.5.1.18 4 61
  • GSTP1-1 3 4
  • FAEES3 3 4
  • GST3 3 4
  • Fatty Acid Ethyl Ester Synthase III 3
  • Epididymis Secretory Protein Li 22 3
  • Glutathione S-Transferase P 3
  • Deafness, X-Linked 7 3
  • HEL-S-22 3
  • DFN7 3
  • GSTP 3
  • PI 3

External Ids for GSTP1 Gene

Previous HGNC Symbols for GSTP1 Gene

  • FAEES3
  • GST3

Previous GeneCards Identifiers for GSTP1 Gene

  • GC11P069874
  • GC11P069047
  • GC11P067601
  • GC11P067126
  • GC11P067107
  • GC11P067351
  • GC11P063681

Summaries for GSTP1 Gene

Entrez Gene Summary for GSTP1 Gene

  • Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTP1 Gene

GSTP1 (Glutathione S-Transferase Pi 1) is a Protein Coding gene. Diseases associated with GSTP1 include Oral Mucosa Leukoplakia and Prostate Cancer. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include glutathione transferase activity and kinase regulator activity. An important paralog of this gene is GSTM3.

UniProtKB/Swiss-Prot for GSTP1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Gene Wiki entry for GSTP1 Gene

PharmGKB "VIP" Summary for GSTP1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTP1 Gene

Genomics for GSTP1 Gene

Regulatory Elements for GSTP1 Gene

Enhancers for GSTP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F067619 0.8 Ensembl ENCODE 12.5 +37.4 37401 2.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B YBX1 RAD21 CHAMP1 SCRT2 ZNF143 NUDT8 DOC2GP ENSG00000260808 GSTP1 RPL37P2 ALDH3B2 ACY3 ENSG00000227834 ENSG00000258297 CDK2AP2
GH11F067710 0.2 Ensembl 4.3 +127.7 127740 2.2 FOSL1 SMARCE1 NFRKB ZBTB33 UNC93B5 GSTP1 GC11P067694
GH11F067579 0.7 Ensembl ENCODE 0.8 +0.6 634 10.5 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000255119 NUDT8 PTPRCAP RBM4B NDUFV1 ENSG00000258297 C11orf72 DOC2GP TBX10 ENSG00000255318
GH11F067572 0.6 Ensembl ENCODE 0.4 -10.6 -10586 1.4 ATF1 ARID4B ZNF2 ZNF143 FOS SP5 REST KAT8 ZNF585B SMARCA4 NDUFV1 RBM4B C11orf72 ENSG00000255119 DOC2GP NUDT8 TBX10 AIP ACY3 ENSG00000227834
GH11F067560 1.1 Ensembl ENCODE 0.3 -20.7 -20711 3.9 PKNOX1 ATF1 GATA2 FOS JUNB REST TBX21 ZNF592 CREB3 MEF2D PTPRCAP AIP NDUFV1 ENSG00000258297 CLCF1 RBM4B CABP2 C11orf72 ENSG00000255119 DOC2GP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GSTP1 on UCSC Golden Path with GeneCards custom track

Promoters for GSTP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000564238 305 1801 HDGF ARID4B SIN3A ELK1 ZNF143 ZNF207 FOS KLF13 DEK ZNF263

Genomic Location for GSTP1 Gene

Chromosome:
11
Start:
67,583,595 bp from pter
End:
67,586,660 bp from pter
Size:
3,066 bases
Orientation:
Plus strand

Genomic View for GSTP1 Gene

Genes around GSTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTP1 Gene

Proteins for GSTP1 Gene

  • Protein details for GSTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09211-GSTP1_HUMAN
    Recommended name:
    Glutathione S-transferase P
    Protein Accession:
    P09211
    Secondary Accessions:
    • O00460
    • Q15690
    • Q5TZY3

    Protein attributes for GSTP1 Gene

    Size:
    210 amino acids
    Molecular mass:
    23356 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK5.

    Three dimensional structures from OCA and Proteopedia for GSTP1 Gene

neXtProt entry for GSTP1 Gene

Selected DME Specific Peptides for GSTP1 Gene

Post-translational modifications for GSTP1 Gene

  • Ubiquitination at Lys 45, Lys 55, Lys 121, and Lys 191
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTP1 Gene

Antibody Products

  • R&D Systems Antibodies for GSTP1 (Glutathione S-Transferase pi 1/GSTP1)
  • Cell Signaling Technology (CST) Antibodies for GSTP1 (GSTP1)

Domains & Families for GSTP1 Gene

Gene Families for GSTP1 Gene

Graphical View of Domain Structure for InterPro Entry

P09211

UniProtKB/Swiss-Prot:

GSTP1_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Pi family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Pi family.
genes like me logo Genes that share domains with GSTP1: view

Function for GSTP1 Gene

Molecular function for GSTP1 Gene

GENATLAS Biochemistry:
glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the esophagus and in Barretts esophagus carcinoma,involved in the DNA methylation of cpG island in prostate cancer and other cancer
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Enzyme Numbers (IUBMB) for GSTP1 Gene

Gene Ontology (GO) - Molecular Function for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA,TAS --
GO:0004602 glutathione peroxidase activity IDA 16624487
GO:0005515 protein binding IPI 16636664
GO:0008144 drug binding IEA --
GO:0008432 JUN kinase binding ISS --
genes like me logo Genes that share ontologies with GSTP1: view
genes like me logo Genes that share phenotypes with GSTP1: view

Animal Models for GSTP1 Gene

MGI Knock Outs for GSTP1:

Animal Model Products

miRNA for GSTP1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTP1 Gene

Localization for GSTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTP1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTP1 Gene COMPARTMENTS Subcellular localization image for GSTP1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 4
plasma membrane 4
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular IDA 18962899
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA,IDA --
genes like me logo Genes that share ontologies with GSTP1: view

Pathways & Interactions for GSTP1 Gene

genes like me logo Genes that share pathways with GSTP1: view

SIGNOR curated interactions for GSTP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0002674 negative regulation of acute inflammatory response NAS 18962899
GO:0006469 negative regulation of protein kinase activity IEA,IDA 16636664
GO:0006749 glutathione metabolic process IDA 1540159
GO:0006805 xenobiotic metabolic process IEA,IDA 1540159
genes like me logo Genes that share ontologies with GSTP1: view

Drugs & Compounds for GSTP1 Gene

(97) Drugs for GSTP1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Enzyme, inhibitor 406,403
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1412
Clomipramine Approved, Vet_approved Pharma Target, inhibitor 24
Chlorambucil Approved Pharma Enzyme, substrate 54

(109) Additional Compounds for GSTP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTP1 Gene

Compound Action Cas Number
Ezatiostat (GST) P1-1 inhibitor 168682-53-9
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with GSTP1: view

Transcripts for GSTP1 Gene

Unigene Clusters for GSTP1 Gene

Glutathione S-transferase pi 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for GSTP1 Gene

GeneLoc Exon Structure for
GSTP1
ECgene alternative splicing isoforms for
GSTP1

Expression for GSTP1 Gene

mRNA expression in normal human tissues for GSTP1 Gene

mRNA differential expression in normal tissues according to GTEx for GSTP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for GSTP1 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTP1 Gene



Protein tissue co-expression partners for GSTP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTP1 Gene:

GSTP1

SOURCE GeneReport for Unigene cluster for GSTP1 Gene:

Hs.523836
genes like me logo Genes that share expression patterns with GSTP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GSTP1 Gene

Orthologs for GSTP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTP1 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia GSTP1 34 35
  • 87.78 (n)
dog
(Canis familiaris)
Mammalia GSTP1 34 35
  • 86.83 (n)
-- 35
  • 85 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gstp2 16 35
  • 84 (a)
Gstp1 34 35
  • 83.49 (n)
BC021614 35
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gstp1 34
  • 82.7 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTP1 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSTP1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstp1 34
  • 57.26 (n)
zebrafish
(Danio rerio)
Actinopterygii gstp1 34 35
  • 63.14 (n)
gstp2 35
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 36 35
  • 39 (a)
gst-23 35
  • 38 (a)
ManyToMany
gst-25 35
  • 35 (a)
ManyToMany
Species where no ortholog for GSTP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTP1 Gene

ENSEMBL:
Gene Tree for GSTP1 (if available)
TreeFam:
Gene Tree for GSTP1 (if available)

Paralogs for GSTP1 Gene

Paralogs for GSTP1 Gene

(8) SIMAP similar genes for GSTP1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GSTP1 Gene

genes like me logo Genes that share paralogs with GSTP1: view

Variants for GSTP1 Gene

Sequence variations from dbSNP and Humsavar for GSTP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1695 drug-response 67,585,218(+) AATAC(A/G)TCTCC reference, missense
rs1065670 -- 67,586,592(+) GGACT(C/T)TGAGC utr-variant-3-prime
rs1079719 -- 67,584,060(+) GGGAG(A/G)GGGGG intron-variant
rs111237844 -- 67,585,662(+) CGTGT(-/GTGCGC)GTGCG intron-variant
rs112120874 -- 67,585,243(+) CTATG(C/T)GAGCA splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTP1 Gene

Variant ID Type Subtype PubMed ID
dgv1214n100 CNV gain 25217958
dgv1981n54 CNV gain 21841781
esv2422195 CNV duplication 17116639
nsv468606 CNV gain 19166990

Variation tolerance for GSTP1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTP1 Gene

Human Gene Mutation Database (HGMD)
GSTP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTP1 Gene

Disorders for GSTP1 Gene

MalaCards: The human disease database

(25) MalaCards diseases for GSTP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oral mucosa leukoplakia
  • leukoplakia, oral
prostate cancer
  • prostate cancer, hereditary, 5
prostate adenocarcinoma
  • adenocarcinoma of prostate
larynx cancer
  • laryngeal benign neoplasm
hepatocellular adenoma
- elite association - COSMIC cancer census association via MalaCards
Search GSTP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTP1

Genetic Association Database (GAD)
GSTP1
Human Genome Epidemiology (HuGE) Navigator
GSTP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTP1
genes like me logo Genes that share disorders with GSTP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTP1 Gene

Publications for GSTP1 Gene

  1. Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. (PMID: 20303013) Cho H.J. … Kong S.Y. (Cancer Genet. Cytogenet. 2010) 3 22 46 64
  2. Genetic polymorphism of GSTP1: prediction of clinical outcome to oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer. (PMID: 20514304) Li Q.F. … Liang J. (J. Korean Med. Sci. 2010) 3 22 46 64
  3. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. (PMID: 19584821) Ansari M. … Krajinovic M. (Bone Marrow Transplant. 2010) 3 22 46 64
  4. Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma. (PMID: 19922504) Chen Y.C. … Wang W.S. (Cancer Sci. 2010) 3 22 46 64
  5. Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents. (PMID: 20197727) Woo H.Y. … Lim S.W. (Korean J Lab Med 2010) 3 22 46 64

Products for GSTP1 Gene

Sources for GSTP1 Gene

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