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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTP1 Gene

protein-coding   GIFtS: 73
GCID: GC11P067351

Glutathione S-Transferase Pi 1


(Previous symbols: FAEES3, GST3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione S-Transferase Pi 11 2     DFN72
GST31 2 3 5     GSTP2
FAEES31 2 3     PI2
GSTP1-12 3     Deafness, X-Linked 72
GST Class-Pi2 3     Fatty Acid Ethyl Ester Synthase III2
EC 2.5.1.183 8     Glutathione S-Transferase P2

External Ids:    HGNC: 46381   Entrez Gene: 29502   Ensembl: ENSG000000842077   OMIM: 1346605   UniProtKB: P092113   

Export aliases for GSTP1 gene to outside databases

Previous GC identifers: GC11P069874 GC11P069047 GC11P067601 GC11P067126 GC11P067107 GC11P063681


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTP1 Gene:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by
catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on
their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes:
alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different
GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to
cancer, and other diseases. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTP1 Gene: 
GSTP1 (glutathione S-transferase pi 1) is a protein-coding gene. Diseases associated with GSTP1 include maxillary sinus squamous cell carcinoma, and atrophy of prostate, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include kinase regulator activity and glutathione transferase activity. An important paralog of this gene is GSTM4.

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration

Gene Wiki entry for GSTP1 Gene

PharmGKB "VIP" summary for GSTP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTP1 gene promoter:
         Sp1   p53   AP-1   MyoD   c-Jun   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): GSTP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

GSTP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067351:  view genomic region     (about GC identifiers)

Start:
67,351,066 bp from pter      End:
67,354,131 bp from pter
Size:
3,066 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211 (See protein sequence)
Recommended Name: Glutathione S-transferase P  
Size: 210 amino acids; 23356 Da
Subunit: Homodimer. Interacts with CDK5
Subcellular location: Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino-acids function as un
uncleaved transit peptide, and arginine residues within it are crucial for motochondrial localization
6/53 PDB 3D structures from and Proteopedia for GSTP1 (see all 53):
10GS (3D)        11GS (3D)        12GS (3D)        13GS (3D)        14GS (3D)        16GS (3D)    
Secondary accessions: O00460 Q15690 Q5TZY3

Explore the universe of human proteins at neXtProt for GSTP1: NX_P09211

Explore proteomics data for GSTP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09211

  • 4/8 DME Specific Peptides for GSTP1 (P09211) (see all 8)
     RMLLADQ  GLYGKDQ  ISFADYNL  FPLLSAYV 

    GSTP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSTP1 Protein Expression
    REFSEQ proteins: NP_000843.1  
    ENSEMBL proteins: 
     ENSP00000381607   ENSP00000381604  
    Reactome Protein details: P09211
    Human Recombinant Protein Products for GSTP1: 
    EMD Millipore Purified and/or Recombinant GSTP1 Protein
    R&D Systems Recombinant & Natural Proteins for GSTP1 (Glutathione S-Transferase pi 1/GSTP1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GSTP1
    OriGene Protein Over-expression Lysate for GSTP1
    OriGene MassSpec for GSTP1 
    OriGene Custom Protein Services for GSTP1
    GenScript Custom Purified and Recombinant Proteins Services for GSTP1
    Novus Biologicals GSTP1 Proteins
    Novus Biologicals GSTP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GSTP1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA18962899
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    GSTP1 for ontologies           About GeneDecksing



    GSTP1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSTP1
    R&D Systems Antibodies for GSTP1 (Glutathione S-Transferase/GST, Glutathione S-Transferase pi 1/GSTP1)
    Cell Signaling Technology (CST) Antibodies for GSTP1 
    OriGene Antibodies for GSTP1
    OriGene Custom Antibody Services for GSTP1
    GenScript Custom Superior Antibodies Services for GSTP1
    Novus Biologicals GSTP1 Antibodies
    Abcam antibodies for GSTP1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for GSTP1
    LSBio Antibodies in human, mouse, rat for GSTP1 

    Assay Products for GSTP1: 
    EMD Millipore Kits and Assays for the Analysis of GSTP1
    OriGene Custom Assay Services for GSTP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GSTP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    5/6 InterPro protein domains (see all 6):
     IPR012336 Thioredoxin-like_fold
     IPR003082 GST_pi
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry P09211

    ProtoNet protein and cluster: P09211

    3 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB003082 Pi-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211
    Similarity: Belongs to the GST superfamily. Pi family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTP1_HUMAN, P09211
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTP1:
    glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the esophagus and in
    Barrett's esophagus carcinoma,involved in the DNA methylation of cpG island in prostate cancer and other cancer

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA1540159
    GO:0005515protein binding IPI16636664
    GO:0008432JUN kinase binding ISS--
    GO:0019207kinase regulator activity ISS--
    GO:0035730S-nitrosoglutathione binding IDA11533048
         
    GSTP1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GSTP1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gstp1):
     growth/size  integument  tumorigenesis 

    GSTP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSTP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSTP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTP1 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GSTP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GSTP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTP1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of GSTP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GSTP1 (see all 7)
    OriGene ORF clones in mouse, rat for GSTP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTP1 (NM_000852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTP1
    Sirion Biotech Customized lentivirus for stable overexpression of GSTP1 
                         Customized lentivirus expression plasmids for stable overexpression of GSTP1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for GSTP1
    Search LifeMap BioReagents cell lines for GSTP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GSTP1 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione conjugation0.60
    Glutathione metabolism0.67
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Acetaminophen metabolism
    Acetaminophen metabolism0.43
    Acetaminophen Pathway, Pharmacokinetics0.43
    4Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    Benzo[a]pyrene metabolism0.43
    Arachidonate Epoxygenase / Epoxide Hydrolase0.36
    5Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for GSTP1
        Naphthalene metabolism
    Acetaminophen metabolism
    Benzo[a]pyrene metabolism
    Glutathione metabolism


    3 Cell Signaling Technology (CST) Pathways for GSTP1
        MAP Kinase Signaling
    Cell Cycle / Checkpoint Control
    Neuroscience

    4 GeneGo (Thomson Reuters) Pathways for GSTP1
        Naphthalene metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism
    Glutathione metabolism

    5 BioSystems Pathways for GSTP1
        Diurnally regulated genes with circadian orthologs
    Arachidonate Epoxygenase / Epoxide Hydrolase
    glutathione-mediated detoxification I
    metapathway biotransformation
    4-hydroxy-2-nonenal detoxification

    4        Reactome Pathways for GSTP1
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation

    5 PharmGKB Pathways for GSTP1
        Acetaminophen Pathway, Pharmacokinetics
    Busulfan Pathway, Pharmacodynamics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    5/6         Kegg Pathways  (Kegg details for GSTP1) (see all 6):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Pathways in cancer
    Chemical carcinogenesis


    GSTP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GSTP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for GSTP1 (P092111, 2, 3 ENSP000003816074) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNO1Q9NRX12, 3MINT-63446 I2D: score=5 
    PTNP212462, 3MINT-63445 I2D: score=5 
    TRAF2Q129331, 3, ENSP000002476684EBI-353467,EBI-355744 I2D: score=3 STRING: ENSP00000247668
    MAPK8P459833, ENSP000003534834I2D: score=3 STRING: ENSP00000353483
    MAP3K5Q996833, ENSP000003519084I2D: score=2 STRING: ENSP00000351908
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ISS--
    GO:0002674negative regulation of acute inflammatory response NAS18962899
    GO:0006469negative regulation of protein kinase activity IDA16636664
    GO:0006749glutathione metabolic process IDA1540159
    GO:0006805xenobiotic metabolic process TAS--

    GSTP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GSTP1 for compounds           About GeneDecksing

    EMD Millipore small molecules for GSTP1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSTP1

    10/12 HMDB Compounds for GSTP1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    10/20 DrugBank Compounds for GSTP1 (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carboxymethylenecysteine-- --target--17139284 17016423 10592235
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetinhibitor15094841 11899840 10592235
    Glutathione Sulfonic Acid-- --target--17139284 17016423 10592235
    S-(P-Nitrobenzyl)Glutathione-- --target--17139284 17016423 10592235
    S-Hexylglutathione-- --target--17139284 17016423 10592235
    (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene-- --target--17139284 17016423
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--17139284 17016423
    ChlorambucilChlocambucil (see all 9)305-03-3enzymesubstrate18511072 14527828
    Cibacron Blue-- 84166-13-2target--17139284 17016423
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17465221 17517071

    10/131 Novoseek inferred chemical compound relationships for GSTP1 gene (see all 131)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 95.3 121 2241927 (4), 10744731 (2), 9425104 (2), 8330352 (1) (see all 99)
    1-chloro-24-dinitrobenzene 84.8 37 2241148 (2), 16316931 (2), 7864646 (1), 16539699 (1) (see all 24)
    ethacrynic acid 80.8 35 9776312 (4), 15911318 (4), 1988111 (2), 9463521 (2) (see all 17)
    epoxide 77 54 1958232 (4), 15668107 (2), 9255563 (1), 11122850 (1) (see all 46)
    s-hexylglutathione 70.4 1 8343114 (1)
    7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 65.6 2 8074309 (1), 1906885 (1)
    gamma-glutamylcysteine 65.2 16 18571892 (2), 7903354 (1), 10762637 (1), 15960885 (1) (see all 13)
    maleylacetoacetate 64.1 1 18096758 (1)
    sulforaphane 63.8 12 18204073 (4), 10814878 (1), 16778223 (1), 9298252 (1) (see all 7)
    brostallicin 63 5 19950984 (4), 16111802 (1)

    8 PharmGKB related drug/compound annotations for GSTP1 gene    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  
    cisplatinCA  
    cyclophosphamideCA  
    epirubicinCA  
    fluorouracilCA  
    methotrexateCA  
    oxaliplatinCA  
    thiotepaCA  

    Search CenterWatch for drugs/clinical trials and news about GSTP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSTP1 gene: 
    NM_000852.3  

    Unigene Cluster for GSTP1:

    Glutathione S-transferase pi 1
    Hs.523836  [show with all ESTs]
    Unigene Representative Sequence: BM926728
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398606(uc001omf.3) ENST00000398603 ENST00000494593 ENST00000464930
    ENST00000476137 ENST00000489040 ENST00000498765 ENST00000467591 ENST00000495996

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GSTP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GSTP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTP1
    Clone
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    OriGene clones in human, mouse for GSTP1 (see all 7)
    OriGene ORF clones in mouse, rat for GSTP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTP1 (NM_000852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTP1
    Sirion Biotech Customized lentivirus for stable overexpression of GSTP1 
                         Customized lentivirus expression plasmids for stable overexpression of GSTP1 
    Primer
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    OriGene qPCR primer pairs and template standards for GSTP1
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTP1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTP1

    Additional mRNA sequence: 

    AY579414.1 AY887902.1 BC010915.1 BT019949.1 BT019950.1 CR450361.1 GQ141553.1 GQ141554.1 
    M69113.1 U30897.1 U62589.1 X06547.1 X15480.1 

    24 DOTS entries:

    DT.453439  DT.92464365  DT.100859245  DT.91737048  DT.40269464  DT.95350104  DT.120691548  DT.91850149 
    DT.95276282  DT.91697086  DT.120691553  DT.95301344  DT.100045398  DT.100646438  DT.120691496  DT.120691528 
    DT.86840764  DT.92357926  DT.95276284  DT.95276285  DT.95276286  DT.95338386  DT.99988672  DT.97856143 

    24/1260 AceView cDNA sequences (see all 1260):

    BE378961 BG010797 BE885320 BG006848 BF870966 AA300198 BM921734 BM758558 
    BU786935 AA292063 CD106887 BI823872 BQ880743 BG014046 AW752970 BM769998 
    AJ707336 BM757631 BG012505 BM921733 BF809562 CR621327 BM758090 AV709921 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                          -     -                                       
    SP2:                          -     -                                       
    SP3:                          -     -           -                           
    SP4:                          -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for GSTP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTP1 expression in normal human tissues (normalized intensities)      GSTP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCCTAGC
    GSTP1 Expression
    About this image


    GSTP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   

    See GSTP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSTP1

    SOURCE GeneReport for Unigene cluster: Hs.523836
        SABiosciences Expression via Pathway-Focused PCR Arrays including GSTP1 (see all 12): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GSTP1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstp11 , 5 glutathione S-transferase, pi 11, 5 83.49(n)1
    85.24(a)1
      19 (3.75 cM)5
    148701  NM_013541.11  NP_038569.11 
     40354115 
    lizard
    (Anolis carolinensis)
    Reptilia GSTP16
    glutathione S-transferase pi 1
    67(a)
    1 ↔ 1
    1(90652114-90682030)
    zebrafish
    (Danio rerio)
    Actinopterygii gstp12 glutathione S-transferase pi 71.29(n)   79381  AF285098.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-13
    Y45G12C.31
    glutathione S-transferase3
    Protein Y45G12C.31
    39(a)3
    49.31(n)1
    40.62(a)1
      III(9130970-9131912)3
    1899321  NM_071297.21  NP_503698.21 


    ENSEMBL Gene Tree for GSTP1 (if available)
    TreeFam Gene Tree for GSTP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTP1 gene
    GSTM42  GSTM12  GSTM32  GSTM52  GSTM22  
    8 SIMAP similar genes for GSTP1 using alignment to 6 protein entries:     GSTP1_HUMAN (see all proteins):
    GSTM1    GSTM3    GSTM2    GSTM4    GSTA3    GSTA1
    GSTA2    GSTM5

    GSTP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GSTP1
    PGOHUM00000239808


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/231 SNPs in GSTP1 are shown (see all 231)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865977911,2
    --63678236(+) ACGCCC/TTAGTC 1 -- us2k10--------
    rs1894391391,2
    --67268782(+) AGTGCA/GTGCAC 1 -- us2k10--------
    rs1132797041,2
    C--67268814(+) GTGATTCTAGTA 
    GTCTAG
    /-
    TCTAG
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1820214281,2
    --67268819(+) TTCTAA/GTTTCG 1 -- us2k10--------
    rs362113991,2
    C--67268820(+) CTAGT-/AGTCT 
    AGTCTAGT
    TTCGC
    1 -- us2k10--------
    rs1865514531,2
    C--67268894(+) CTGTTC/TGTGCA 1 -- us2k10--------
    rs2002572801,2
    C--67268938(+) GCTGG-/TTTTTA 1 -- us2k10--------
    rs79493941,2
    C,F,A,H--67268944(+) ttttaC/Tggctc 1 -- us2k1 tfbs34Minor allele frequency- T:0.09NA WA CSA EA 126
    rs79495871,2
    C,F,A,H--67268971(+) cctgcG/Agacat 1 -- us2k17Minor allele frequency- A:0.30WA CSA NA EA 365
    rs65912551,2
    C,F,A--67269172(+) atttcT/Agtttt 1 -- us2k111Minor allele frequency- A:0.32NS NA WA CSA EA 541

    HapMap Linkage Disequilibrium report for GSTP1 (67351066 - 67354131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GSTP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422195CNV Duplication17116639
    dgv1194n71CNV Loss21882294
    nsv897815CNV Loss21882294
    nsv897801CNV Loss21882294
    dgv1196n71CNV Loss21882294
    nsv468606CNV Gain19166990


    Human Gene Mutation Database (HGMD): GSTP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTP1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134660    OMIM disorders: --

    20/223 diseases for GSTP1 (see all 223):    About MalaCards
    maxillary sinus squamous cell carcinoma    atrophy of prostate    plasmodium vivax malaria    cardia cancer
    prostatic hypertrophy    epstein-barr virus-associated gastric carcinoma    bladder cancer susceptibility    severe pre-eclampsia
    bilateral breast cancer    exfoliation syndrome    hellp syndrome    pre-eclampsia
    eclampsia    asbestosis    hepatocellular adenoma    diffuse gastric cancer
    rosacea    migraine without aura    alcoholic pancreatitis    substance dependence

    8 diseases from the University of Copenhagen DISEASES database for GSTP1:
    Prostate cancer     Carcinoma     Lung cancer     Breast cancer
    Colorectal cancer     Urinary bladder cancer     Asthma     Esophageal cancer

    GSTP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for GSTP1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 65.4 142 15126784 (4), 9511178 (3), 12576869 (3), 10692562 (2) (see all 99)
    prostate cancer 61.4 194 15649863 (5), 10022813 (5), 19143011 (5), 11549474 (4) (see all 89)
    tumors 59.2 281 9635537 (5), 16527261 (5), 18425080 (5), 15126784 (4) (see all 99)
    prostatic intraepithelial neoplasia 57 12 11549474 (1), 11857497 (1), 12845678 (1), 11550208 (1) (see all 11)
    cancer lung 52.7 104 15105047 (6), 19240225 (5), 11004766 (4), 19282111 (4) (see all 46)
    carcinoma squamous cell 52.5 32 19750576 (2), 11037818 (2), 16982972 (2), 11783067 (2) (see all 28)
    genetic susceptibility 48.7 5 17696749 (2), 15466980 (1), 12497653 (1), 12172904 (1)
    gastric cancer 46.8 40 20377137 (4), 19247656 (3), 7857716 (2), 16615268 (2) (see all 26)
    prostate carcinoma 46.1 30 15623627 (3), 16446401 (2), 9184779 (2), 11085508 (2) (see all 18)
    bladder cancer 46 39 11061940 (5), 18979064 (3), 8311448 (2), 16849682 (2) (see all 18)

    Genetic Association Database (GAD): GSTP1
    Human Genome Epidemiology (HuGE) Navigator: GSTP1 (884 documents)

    Export disorders for GSTP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTP1 gene, integrated from 9 sources (see all 2199):
    (articles sorted by number of sources associating them with GSTP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. (PubMed id 11081456)1, 4, 7 Peters U....Lamprecht-Dinnesen A. (2000)
    2. The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer. (PubMed id 12148855)1, 4, 9 Kelders W.P....Manni J.J. (2002)
    3. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. (PubMed id 19143011)1, 4, 9 Mo Z....Jian L. (2009)
    4. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility. (PubMed id 17428572)1, 4, 9 Yang M....Lee J.S. (2007)
    5. The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene. (PubMed id 17643058)1, 4, 9 Kamada F....Suzuki Y. (2007)
    6. Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India. (PubMed id 16631467)1, 4, 9 Sobti R.C....Nakahara A. (2006)
    7. I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. (PubMed id 12010858)1, 4, 9 Jeronimo C....Sidransky D. (2002)
    8. Tyrosine phosphorylation of the human glutathione S-t ransferase P1 by epidermal growth factor receptor. (PubMed id 19254954)1, 2, 9 Okamura T....Ali-Osman F. (2009)
    9. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. (PubMed id 19240225)1, 4, 9 Cote M.L....Taioli E. (2009)
    10. [Transferase S-glutathione class pi gene (GSTP1) polymorphism in thyroid cancer patients] (PubMed id 17133316)1, 4, 9 Marciniak P....Sowinski J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2950 HGNC: 4638 AceView: GSTP1 Ensembl:ENSG00000084207 euGenes: HUgn2950
    ECgene: GSTP1 Kegg: 2950 H-InvDB: GSTP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gstp1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTP1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSTP1 gene:
    Search GeneIP for patents involving GSTP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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