Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GSTP1 Gene

Aliases for GSTP1 Gene

  • Glutathione S-Transferase Pi 1 2 3 5
  • GST Class-Pi 3 4
  • EC 2.5.1.18 4 63
  • GSTP1-1 3 4
  • FAEES3 3 4
  • GST3 3 4
  • Fatty Acid Ethyl Ester Synthase III 3
  • Epididymis Secretory Protein Li 22 3
  • Deafness, X-Linked 7 3
  • HEL-S-22 3
  • DFN7 3
  • GSTP 3
  • PI 3

External Ids for GSTP1 Gene

Previous HGNC Symbols for GSTP1 Gene

  • FAEES3
  • GST3

Previous GeneCards Identifiers for GSTP1 Gene

  • GC11P069874
  • GC11P069047
  • GC11P067601
  • GC11P067126
  • GC11P067107
  • GC11P067351
  • GC11P063681

Summaries for GSTP1 Gene

Entrez Gene Summary for GSTP1 Gene

  • Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTP1 Gene

GSTP1 (Glutathione S-Transferase Pi 1) is a Protein Coding gene. Diseases associated with GSTP1 include oral mucosa leukoplakia and prostate cancer. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include glutathione transferase activity and kinase regulator activity. An important paralog of this gene is GSTM5.

UniProtKB/Swiss-Prot for GSTP1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Gene Wiki entry for GSTP1 Gene

PharmGKB "VIP" Summary for GSTP1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTP1 Gene

Genomics for GSTP1 Gene

Regulatory Elements for GSTP1 Gene

Promoters for GSTP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSTP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTP1 Gene

Chromosome:
11
Start:
67,583,595 bp from pter
End:
67,586,660 bp from pter
Size:
3,066 bases
Orientation:
Plus strand

Genomic View for GSTP1 Gene

Genes around GSTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTP1 Gene

Proteins for GSTP1 Gene

  • Protein details for GSTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09211-GSTP1_HUMAN
    Recommended name:
    Glutathione S-transferase P
    Protein Accession:
    P09211
    Secondary Accessions:
    • O00460
    • Q15690
    • Q5TZY3

    Protein attributes for GSTP1 Gene

    Size:
    210 amino acids
    Molecular mass:
    23356 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK5.

    Three dimensional structures from OCA and Proteopedia for GSTP1 Gene

neXtProt entry for GSTP1 Gene

Proteomics data for GSTP1 Gene at MOPED

Selected DME Specific Peptides for GSTP1 Gene

Post-translational modifications for GSTP1 Gene

  • Ubiquitination at Lys 45, Lys 55, Lys 121, and Lys 191
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTP1 Gene

Antibody Products

  • R&D Systems Antibodies for GSTP1 (Glutathione S-Transferase pi 1/GSTP1)
  • Cell Signaling Technology (CST) Antibodies for GSTP1 (GSTP1)

Domains & Families for GSTP1 Gene

Gene Families for GSTP1 Gene

Graphical View of Domain Structure for InterPro Entry

P09211

UniProtKB/Swiss-Prot:

GSTP1_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Pi family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Pi family.
genes like me logo Genes that share domains with GSTP1: view

Function for GSTP1 Gene

Molecular function for GSTP1 Gene

GENATLAS Biochemistry:
glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the esophagus and in Barretts esophagus carcinoma,involved in the DNA methylation of cpG island in prostate cancer and other cancer
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Enzyme Numbers (IUBMB) for GSTP1 Gene

Gene Ontology (GO) - Molecular Function for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16636664
GO:0043295 glutathione binding IEA --
genes like me logo Genes that share ontologies with GSTP1: view
genes like me logo Genes that share phenotypes with GSTP1: view

Animal Models for GSTP1 Gene

MGI Knock Outs for GSTP1:

Animal Model Products

miRNA for GSTP1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTP1 Gene

Localization for GSTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTP1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTP1 Gene COMPARTMENTS Subcellular localization image for GSTP1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 4
plasma membrane 4
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with GSTP1: view

Pathways & Interactions for GSTP1 Gene

genes like me logo Genes that share pathways with GSTP1: view

SIGNOR curated interactions for GSTP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0002674 negative regulation of acute inflammatory response NAS 18962899
GO:0006749 glutathione metabolic process IDA 1540159
GO:0006805 xenobiotic metabolic process IEA,IDA 1540159
GO:0007417 central nervous system development TAS 9802272
genes like me logo Genes that share ontologies with GSTP1: view

Drugs & Compounds for GSTP1 Gene

(91) Drugs for GSTP1 Gene - From: Novoseek, HMDB, DrugBank, ApexBio, DGIdb, PharmGKB, ClinicalTrials, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Enzyme, inhibitor 371,376
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1322
Clomipramine Approved Pharma Target, inhibitor 24
Chlorambucil Approved Pharma Enzyme, substrate 52

(112) Additional Compounds for GSTP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTP1 Gene

Compound Action Cas Number
Ezatiostat (GST) P1-1 inhibitor 168682-53-9
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with GSTP1: view

Transcripts for GSTP1 Gene

Unigene Clusters for GSTP1 Gene

Glutathione S-transferase pi 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for GSTP1 Gene

GeneLoc Exon Structure for
GSTP1
ECgene alternative splicing isoforms for
GSTP1

Expression for GSTP1 Gene

mRNA expression in normal human tissues for GSTP1 Gene

mRNA differential expression in normal tissues according to GTEx for GSTP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for GSTP1 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTP1 Gene



SOURCE GeneReport for Unigene cluster for GSTP1 Gene Hs.523836

genes like me logo Genes that share expression patterns with GSTP1: view

Protein tissue co-expression partners for GSTP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GSTP1 Gene

Orthologs for GSTP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSTP1 35
  • 87.78 (n)
  • 86.19 (a)
GSTP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSTP1 35
  • 86.83 (n)
  • 87.14 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
GSTP1 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gstp1 35
  • 83.49 (n)
  • 85.24 (a)
Gstp2 16
BC021614 36
  • 70 (a)
OneToMany
Gstp1 36
  • 85 (a)
OneToMany
Gstp2 36
  • 84 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GSTP1 35
  • 99.68 (n)
  • 99.52 (a)
GSTP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gstp1 35
  • 82.7 (n)
  • 85.71 (a)
oppossum
(Monodelphis domestica)
Mammalia GSTP1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSTP1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstp1 35
  • 57.26 (n)
  • 55.98 (a)
zebrafish
(Danio rerio)
Actinopterygii gstp1 35
  • 63.14 (n)
  • 60.58 (a)
gstp1 36
  • 61 (a)
OneToMany
gstp2 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 37
  • 39 (a)
gst-1 36
  • 39 (a)
ManyToMany
gst-23 36
  • 38 (a)
ManyToMany
gst-25 36
  • 35 (a)
ManyToMany
Species with no ortholog for GSTP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTP1 Gene

ENSEMBL:
Gene Tree for GSTP1 (if available)
TreeFam:
Gene Tree for GSTP1 (if available)

Paralogs for GSTP1 Gene

Paralogs for GSTP1 Gene

(8) SIMAP similar genes for GSTP1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GSTP1 Gene

genes like me logo Genes that share paralogs with GSTP1: view

Variants for GSTP1 Gene

Sequence variations from dbSNP and Humsavar for GSTP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1695 - 67,585,218(+) AATAC(A/G)TCTCC reference, missense
rs1138272 - 67,586,108(+) GGAGG(C/T)GGGCA reference, missense
rs41462048 - 67,586,450(+) CCCTG(A/G)CTGCC reference, missense
rs4891 -- 67,586,499(+) CTCAG(C/T)GCCCG reference, synonymous-codon
rs675554 -- 67,585,679(-) ACACA(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTP1 Gene

Variant ID Type Subtype PubMed ID
nsv897801 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
esv2422195 CNV Duplication 17116639
dgv1196n71 CNV Loss 21882294
nsv897815 CNV Loss 21882294
nsv468606 CNV Gain 19166990

Variation tolerance for GSTP1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTP1 Gene

HapMap Linkage Disequilibrium report
GSTP1
Human Gene Mutation Database (HGMD)
GSTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTP1 Gene

Disorders for GSTP1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for GSTP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oral mucosa leukoplakia
  • leukoplakia, oral
prostate cancer
  • prostate cancer, hereditary, 5
prostate adenocarcinoma
  • adenocarcinoma of prostate
ovarian cyst
  • ovarian cysts
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
- elite association - COSMIC cancer census association via MalaCards
Search GSTP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTP1

Genetic Association Database (GAD)
GSTP1
Human Genome Epidemiology (HuGE) Navigator
GSTP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTP1
genes like me logo Genes that share disorders with GSTP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTP1 Gene

Publications for GSTP1 Gene

  1. Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi. (PMID: 17029404) Ralat L.A. … Colman R.F. (Biochemistry 2006) 3 23 25 26
  2. The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer. (PMID: 12148855) Kelders W.P. … Manni J.J. (Laryngoscope 2002) 3 23 48 67
  3. [Tricyclic antidepressants as inhibitors of brain glutathione-S-transferase]. (PMID: 11899840) BaraA8czyk-KuA_ma A. … JagieA8A8o J. (Pol. Merkur. Lekarski 2001) 23 25 26
  4. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. (PMID: 19584821) Ansari M. … Krajinovic M. (Bone Marrow Transplant. 2010) 3 23
  5. Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. (PMID: 19856314) Pandey M. … Gupta S. (Int. J. Cancer 2010) 3 23

Products for GSTP1 Gene

Sources for GSTP1 Gene

Back to Top

Content