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GSTP1 Gene

protein-coding GIFtS: 74

GC11P067107

glutathione S-transferase pi 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FAEES3, GST3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DFN7 ^²
EC 2.5.1.18 ^³
FAEES3 ^², ³
GST3 ^², ³, ⁵
GSTP1-1 ^³
OTTHUMP00000174659 ^²
PI ^²

Descriptions
GST class-pi ^³
deafness, X-linked 7 ^²
fatty acid ethyl ester synthase III ^²
glutathione S-transferase pi 1 ^²
glutathione transferase ^²

External Ids
HGNC: 4638¹
Entrez Gene: 2950²
UniProtKB: P09211³
Ensembl: ENSG00000084207⁷

Search outside databases for aliases for GSTP1 gene

Previous GC identifers: GC11P069874 GC11P069047 GC11P067601 GC11P067126

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GSTP1:

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in

detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with

reduced glutathione. Based on their biochemical, immunologic, and structural properties, the

soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member

is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are

thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and

other diseases. [provided by RefSeq]

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous

hydrophobic electrophiles

Gene Wiki entry for GSTP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GSTP1 gene

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13-qter

GSTP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P067107: (about GC identifiers)

Start:	67,107,642 bp from pter
End:	67,110,707 bp from pter
Size:	3,066 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211 (See protein sequence)

Recommended Name: Glutathione S-transferase P

Size: 210 amino acids; 23356 Da

Subunit: Homodimer

PDB structures from and Proteopedia :

10GS (3D)

11GS (3D)

12GS (3D)

13GS (3D)

14GS (3D)

16GS (3D)

17GS (3D)

18GS (3D)

19GS (3D)

1AQV (3D)

1AQW (3D)

1AQX (3D)

1EOG (3D)

1EOH (3D)

1GSS (3D)

1KBN (3D)

1LBK (3D)

1MD3 (3D)

1MD4 (3D)

1PGT (3D)

1PX6 (3D)

1PX7 (3D)

1ZGN (3D)

20GS (3D)

22GS (3D)

2A2R (3D)

2A2S (3D)

2GSS (3D)

2J9H (3D)

2PGT (3D)

3CSH (3D)

3CSI (3D)

3CSJ (3D)

3DD3 (3D)

3DGQ (3D)

3GSS (3D)

3PGT (3D)

4GSS (3D)

4PGT (3D)

5GSS (3D)

6GSS (3D)

7GSS (3D)

8GSS (3D)

9GSS (3D)

Secondary accessions: O00460 Q15690 Q5TZY3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000843.1

ENSEMBL proteins:

ENSP00000381604 ENSP00000381607 ENSP00000196968

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant GSTP1 Protein
	Sigma-Aldrich Proteins for GSTP1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GST3 / GST pi)
	Human Recombinant Proteins from Abnova (GSTP1)

OriGene Purified Recombinant Human Protein: GSTP1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	16130169

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Antibodies for GSTP1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GSTP1
	Sigma-Aldrich Antibodies for GSTP1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for GSTP1
	Antibodies from Abcam (GST3 / GST pi), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GSTP1)
	Novus Biologicals Antibodies for GSTP1

Assays for GSTP1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of GSTP1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09211

ProtoNet protein and cluster: P09211

3 Blocks protein families:

IPB003080 Alpha-class glutathione S-transferase signature

IPB003082 Pi-class glutathione S-transferase signature

IPB004045 Glutathione S-transferase

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211

Similarity: Belongs to the GST superfamily. Pi family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSTP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GSTP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000852

Applied Biosystems Silencer® siRNAs for GSTP1

Sigma-Aldrich siRNA for GSTP1

Sigma-Aldrich shRNA for GSTP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GSTP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000852
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000852
untagged cDNA clone in CMV expression vector: NM_000852

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000852

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous

hydrophobic electrophiles

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Enzyme Number (IUBMB): EC 2.5.1.18

Genatlas biochemistry entry for GSTP1:

glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the

esophagus and in Barrett's esophagus carcinoma,involved in the DNA methylation of cpG island in

prostate cancer and other cancer

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gstp1):

growth/size

skin/coat/nails

tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IEA	--
GO:0005515	protein binding	IPI	16636664
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GSTP1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Glutathione Metabolism
Xenobiotic Metabolism Signaling
NRF2-mediated Oxidative Stress Response
LPS/IL-1 Mediated Inhibition of RXR Function
Aryl Hydrocarbon Receptor Signaling

GeneDecks GSTP1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GSTP1

5/105 Interacting proteins for GSTP1 (P09211^{1, 2} ENSP00000196968³) via UniProtKB, MINT, and/or STRING (see all 105 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K5	Q99683¹	EBI-353467, EBI-476263
MAPK14	Q16539¹	EBI-353467, EBI-73946
TRAF2	Q12933¹	EBI-353467, EBI-355744
PNO1	Q9NRX1²	MINT-63446
PTN	P21246²	MINT-63445

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006916	anti-apoptosis	TAS	16130169
GO:0007417	central nervous system development	TAS	9802272
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GSTP1 available from Tocris Bioscience

Compound	Action	CAS number
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

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10/33 Novoseek chemical compound relationships for GSTP1 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	95.23	112	2241927 (4), 10744731 (2), 9425104 (2), 8330352 (1) (see all 99)
1-chloro-24-dinitrobenzene	84.81	37	2241148 (2), 16316931 (2), 7864646 (1), 16539699 (1) (see all 24)
epoxide	78.27	54	1958232 (4), 15668107 (2), 9255563 (1), 11122850 (1) (see all 46)
tlk 199	64.97	1	10860939 (1)
noradrenochrome	64.97	2	9164836 (1), 12835099 (1)
gamma-glutamylcysteine	64.85	14	7903354 (1), 10762637 (1), 15960885 (1), 16882163 (1) (see all 12)
maleylacetoacetate	64.73	1	18096758 (1)
1-hydroxypyrene	57.98	4	9800384 (2), 14644327 (1)
s-(2,4-dinitrophenyl)glutathione	57.80	1	7727393 (1)
brostallicin	57.06	1	16111802 (1)

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10/15 PharmGKB drug compound relationships for GSTP1 gene (see all 15 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
asparaginase	CO	15713801
chlorambucil	FA	9685354
cisplatin	FA	12481432
cytarabine	CO	15713801
daunorubicin	CO	15713801
doxorubicin	FA	9685354
etoposide	CO FA	8763337 9685354 15713801
fluorouracil	CO	12072547
mercaptopurine	CO	15713801
methotrexate	CO	15713801

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSTP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GSTP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000852

Sigma-Aldrich siRNA for GSTP1

Sigma-Aldrich shRNA for GSTP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000852

REFSEQ mRNAs for GSTP1 gene:

NM_000852.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000852

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000852
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000852
                                 untagged cDNA clone in CMV expression vector: NM_000852

Additional cDNA sequence:

AY579414.1 AY887902.1 BC010915.1 BT019949.1 BT019950.1 CR450361.1 CR593425.1 CR596191.1

CR602934.1 CR604216.1 CR604255.1 CR609234.1 CR621327.1 M69113.1 U30897.1 U62589.1

X06547.1 X15480.1

24 DOTS entries:

DT.453439 DT.92464365 DT.100859245 DT.91737048 DT.40269464 DT.95350104 DT.120691548 DT.91850149

DT.95276282 DT.91697086 DT.120691553 DT.95301344 DT.100045398 DT.100646438 DT.120691496 DT.120691528

DT.86840764 DT.92357926 DT.95276284 DT.95276285 DT.95276286 DT.95338386 DT.99988672 DT.97856143

24/1260 AceView cDNA sequences (see all 1260 ):

AW163051 BM758983 CB044243 F34991 BE711142 AA304091 AJ573915 BU557230

BM758090 BU734348 BM851253 BM851283 CR604255 BF870966 AA300198 F35598

BU727836 BP431352 BM757647 BM016302 BM551510 BG011079 CD672914 BG012969

highest scoring ESTs for GSTP1:

AA010226 AA029274 AA029539 AA070401 AA083622 AA095365 AA122001 AA157084 AA158826 AA161112

Unigene Cluster for GSTP1:

Glutathione S-transferase pi 1

Hs.523836 [show with all ESTs]

Unigene Representative Sequence: BM926728

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d
SP1:									-		-
SP2:									-		-
SP3:									-		-				-
SP4:									-
SP5:

About this scheme

ECgene alternative splicing isoforms for GSTP1

3 Ensembl transcripts including schematic representations:

ENST00000398603 ENST00000398606 ENST00000196968

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GSTP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GSTP1

¹ / ² / ³

4 probe-sets matching GSTP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33396_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.00	U12472	0.20	1.00	0.72	1
829_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.00	U21689	0.20	1.00	0.72	1
200824_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000852	0.60	1.00	0.82	1
200824_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGTCCTAGC

SOURCE GeneReport for Unigene cluster: Hs.523836
Expression variation in blood from EXPOLDB for GSTP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GSTP1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	GSTP1¹	--	glutathione S-transferase pi 1	97.89(n) 97.07(a)	745954 XM_001152516.1 XP_001152516.1
mouse (Mus musculus)	Gstp1^{1, 5}	19 (0.00 cM)⁵	glutathione S-transferase, pi 1^{1, 5}	83.33(n)¹ 85.24(a)¹	14870¹ NM_013541.1¹ NP_038569.1¹ AK079144⁵ BC002048⁵ (see all 11)
zebrafish (Danio rerio)	gstp1²	--	glutathione S-transferase pi	71.29(n)	79381 AF285098.1
worm (Caenorhabditis elegans)	gst-1³ Y45G12C.3¹	III(9130970-9131912)³	glutathione S-transferase³ hypothetical protein¹	39(a)³ 49.31(n)¹ 40.62(a)¹	189932¹ NM_071297.2¹ NP_503698.2¹

About this table Species with no ortholog for GSTP1

ENSEMBL Gene Tree for GSTP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/112 NCBI SNPs in GSTP1 are shown (see all 112 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs947895^1,2	A,C,F,H,O	67110982(+)	`CAGCAC/AGTGCC`	1	--	ng3¹		12	EA NA NS EU WA	1052
	rs6591256^1,2	A,C,F,H	67106475(+)	`TTTAAA/GGATAC`	1	--	ng5¹		18	EU EA WA NS NA	1796
	rs4986949^1,2	C,F,H	67110253(+)	`TGGGAG/TACCAG`	1	D/Y	mis¹ ese³		11	MN CSAM EA EU WA	1468
	rs8191431^1,2	C,F,H	67106630(+)	`GCCAAC/TAAGAG`	1	--	ng5¹		8	NS EU EA WA NA	732
--	rs6591255^1,2	A,C,F	67106124(+)	`atttcT/Agtttt`	1	--	ng5¹		1	NS	170
	rs1695^1,2	C,F,H	67109265(+)	`AATACA/GTCTCC`	1	I/V	mis¹		34	MN EU EA WA CSAM NS NA	4024
--	rs8191439^1,2	C,F,H	67107873(+)	`TCGCCG/ACCGCA`	1	--	ut5¹		15	NS EU EA WA NA	1862
	rs1138272^1,2	C,F,H	67110155(+)	`GGAGGC/TGGGCA`	1	A/V	mis¹		22	MN CSAM EA NS EU WA NA	2626
	rs4986948^1,2	C,F,H	67109281(+)	`CTACAC/GCAACT`	1	T/S	mis¹ ese³		10	MN CSAM EA EU WA	990
--	rs36211088^1,2	C,F	67107575(+)	`CAGTTC/AGCTGC`	1	--	ng5¹		1	--	480

About this table

HapMap Linkage Disequilibrium images for GSTP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134660

10/93 Novoseek disease relationships for GSTP1 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	65.05	129	15126784 (4), 9511178 (3), 12576869 (3), 10692562 (2) (see all 99)
prostate cancer	61.04	180	15649863 (5), 10022813 (5), 19143011 (5), 11549474 (4) (see all 81)
prostatic intraepithelial neoplasia	58.59	12	11549474 (1), 11857497 (1), 12845678 (1), 11550208 (1) (see all 11)
tumors	58.41	263	9635537 (5), 16527261 (5), 18425080 (5), 15126784 (4) (see all 99)
cancer lung	53.47	99	15105047 (6), 19240225 (5), 11004766 (4), 10376794 (4) (see all 44)
carcinoma squamous cell	51.01	30	11037818 (2), 16982972 (2), 11783067 (2), 16219146 (1) (see all 27)
prostate carcinoma	47.75	30	15623627 (3), 16446401 (2), 9184779 (2), 11085508 (2) (see all 18)
bladder cancer	47.48	38	11061940 (5), 18979064 (3), 8311448 (2), 16849682 (2) (see all 17)
genetic susceptibility	46.51	5	17696749 (2), 15466980 (1), 12497653 (1), 12172904 (1)
benign prostatic hyperplasia	45.91	20	15289848 (2), 12475696 (2), 11549474 (1), 11708494 (1) (see all 16)

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6 PharmGKB disease relationships for GSTP1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Colorectal Neoplasms	CO	12072547
Emphysema	FA	11350797
Leukemia, Lymphocytic, Acute, L1	CO	15713801
Lung Neoplasms	FA GN	12367788 11350797
Neoplasms	PK	15173075
Ovarian Neoplasms	FA	12481432

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Human Gene Mutation Database: GSTP1
Genetic Association Database: GSTP1
Human Genome Epidemiology Navigator: GSTP1 (643 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1592 PubMed articles for GSTP1 gene (see all 1592 ):

Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. (PubMed id 12072547)^{3, 6, 7} Stoehlmacher J....Lenz H.J. (2002)
Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis. (PubMed id 16157826)^{1, 3, 6} Stickel F....Schuppan D. (2005)
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)^{1, 3, 6} Dialyna I.A....Spandidos D.A. (2001)
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. (PubMed id 16079101)^{1, 3, 6} Dufour C.... . (2005)
[Polymorphism of glutathione-S-transferase M1 and P1 genes in patients with cystic fibrosis and chronic respiratory tract diseases] (PubMed id 15125256)^{1, 3, 6} Korytina G.F....Viktorova T.V. (2004)
Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms. (PubMed id 14501269)^{1, 3, 6} Miller D.P....Christiani D.C. (2003)
Association study between glutathione S-transferase P1 polymorphism and schizophrenia in the Korean population. (PubMed id 12691788)^{1, 3, 6} Pae C.U....Serretti A. (2003)
Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. (PubMed id 11040079)^{1, 3, 6} Juronen E....Mikelsaar A.V. (2000)
GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia. (PubMed id 15717687)^{1, 3, 6} Stanulla M....Schwab M. (2005)
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children. (PubMed id 15928955)^{1, 3, 6} Korytina G.F....Victorova T.V. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2950	HGNC: 4638	AceView: GSTP1	Ensembl:ENSG00000084207	euGenes: HUgn2950
ECgene: GSTP1	H-InvDB: GSTP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GSTP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/gstp1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTP1

Licensable Technologies for GSTP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GSTP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GSTP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GSTP1		Antibodies for GSTP1
	Explore super-pooled esiRNAs		Proteins for GSTP1
	Lentivirus-delivered shRNAs for GSTP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GSTP1)
	Antibodies (GSTP1)
	Chimera RNAi (GSTP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GSTP1

	Recombinant Proteins (GST3 / GST pi)
	Antibodies (GST3 / GST pi)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for GSTP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GSTP1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GSTP1 Gene at Home site.
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GSTP1 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for GSTP1

Summaries
for GSTP1

Genomic Location
for GSTP1

Proteins
for GSTP1

Protein Domains/
Families
for GSTP1

Gene Function
for GSTP1

Pathways & Interactions
for GSTP1

Drugs & Compounds
for GSTP1

Transcripts
for GSTP1

Expression
for GSTP1

Orthologs
for GSTP1

Paralogs
for GSTP1

SNPs/Variants
for GSTP1

Disorders & Mutations
for GSTP1

Medical News
for GSTP1

Publications
for GSTP1

Search for GSTP1

Genome Databases showing GSTP1

Other Databases showing GSTP1

Specialized Databases showing GSTP1

Licensable Technologies
for GSTP1

Services
for GSTP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GSTP1 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor GSTP1

Summariesfor GSTP1

Genomic Locationfor GSTP1

Proteinsfor GSTP1

Protein Domains/Familiesfor GSTP1

Gene Functionfor GSTP1

Pathways & Interactionsfor GSTP1

Drugs & Compoundsfor GSTP1

Transcriptsfor GSTP1

Expression for GSTP1

Orthologsfor GSTP1

Paralogsfor GSTP1

SNPs/Variantsfor GSTP1

Disorders & Mutationsfor GSTP1

Medical Newsfor GSTP1

Publicationsfor GSTP1

Search for GSTP1

Genome Databases showing GSTP1

Other Databases showing GSTP1

Specialized Databases showing GSTP1

Licensable Technologiesfor GSTP1

Servicesfor GSTP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GSTP1

Summaries
for GSTP1

Genomic Location
for GSTP1

Proteins
for GSTP1

Protein Domains/
Families
for GSTP1

Gene Function
for GSTP1

Pathways & Interactions
for GSTP1

Drugs & Compounds
for GSTP1

Transcripts
for GSTP1

Expression
for GSTP1

Orthologs
for GSTP1

Paralogs
for GSTP1

SNPs/Variants
for GSTP1

Disorders & Mutations
for GSTP1

Medical News
for GSTP1

Publications
for GSTP1

Licensable Technologies
for GSTP1

Services
for GSTP1