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Aliases for GSTP1 Gene

Aliases for GSTP1 Gene

  • Glutathione S-Transferase Pi 1 2 3
  • GST3 3 4 6
  • GST Class-Pi 3 4
  • EC 2.5.1.18 4 63
  • GSTP1-1 3 4
  • FAEES3 3 4
  • Fatty Acid Ethyl Ester Synthase III 3
  • Epididymis Secretory Protein Li 22 3
  • Glutathione S-Transferase P 3
  • Deafness, X-Linked 7 3
  • HEL-S-22 3
  • DFN7 3
  • GSTP 3
  • PI 3

External Ids for GSTP1 Gene

Previous HGNC Symbols for GSTP1 Gene

  • FAEES3
  • GST3

Previous GeneCards Identifiers for GSTP1 Gene

  • GC11P069874
  • GC11P069047
  • GC11P067601
  • GC11P067126
  • GC11P067107
  • GC11P067351
  • GC11P063681

Summaries for GSTP1 Gene

Entrez Gene Summary for GSTP1 Gene

  • Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTP1 Gene

GSTP1 (Glutathione S-Transferase Pi 1) is a Protein Coding gene. Diseases associated with GSTP1 include maxillary sinus squamous cell carcinoma and cardia cancer. Among its related pathways are Pathways in cancer and Glioma. GO annotations related to this gene include glutathione transferase activity and kinase regulator activity. An important paralog of this gene is GSTM3.

UniProtKB/Swiss-Prot for GSTP1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Gene Wiki entry for GSTP1 Gene

PharmGKB "VIP" Summary for GSTP1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTP1 Gene

Genomics for GSTP1 Gene

Regulatory Elements for GSTP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GSTP1 Gene

Start:
67,583,595 bp from pter
End:
67,586,660 bp from pter
Size:
3,066 bases
Orientation:
Plus strand

Genomic View for GSTP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTP1 Gene

Proteins for GSTP1 Gene

  • Protein details for GSTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09211-GSTP1_HUMAN
    Recommended name:
    Glutathione S-transferase P
    Protein Accession:
    P09211
    Secondary Accessions:
    • O00460
    • Q15690
    • Q5TZY3

    Protein attributes for GSTP1 Gene

    Size:
    210 amino acids
    Molecular mass:
    23356 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK5.

    Three dimensional structures from OCA and Proteopedia for GSTP1 Gene

neXtProt entry for GSTP1 Gene

Proteomics data for GSTP1 Gene at MOPED

Selected DME Specific Peptides for GSTP1 Gene

Post-translational modifications for GSTP1 Gene

  • Ubiquitination at Lys45, Lys55, Lys121, Lys128, and Lys191
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GSTP1 (Glutathione S-Transferase pi 1/GSTP1)
  • R&D Systems Antibodies for GSTP1 (Glutathione S-Transferase/GST)
  • Cell Signaling Technology (CST) Antibodies for GSTP1 (GSTP1)

Domains for GSTP1 Gene

Gene Families for GSTP1 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

Graphical View of Domain Structure for InterPro Entry

P09211

UniProtKB/Swiss-Prot:

GSTP1_HUMAN :
  • P09211
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Pi family.
genes like me logo Genes that share domains with GSTP1: view

Function for GSTP1 Gene

Molecular function for GSTP1 Gene

GENATLAS Biochemistry: glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the esophagus and in Barretts esophagus carcinoma,involved in the DNA methylation of cpG island in prostate cancer and other cancer
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Enzyme Numbers (IUBMB) for GSTP1 Gene

Gene Ontology (GO) - Molecular Function for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 1540159
GO:0005515 protein binding IPI 16636664
GO:0008432 JUN kinase binding ISS --
GO:0019207 kinase regulator activity ISS --
GO:0035730 S-nitrosoglutathione binding IDA 11533048
genes like me logo Genes that share ontologies with GSTP1: view
genes like me logo Genes that share phenotypes with GSTP1: view

Animal Model Products

CRISPR Products

miRNA for GSTP1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTP1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GSTP1 Gene

Localization for GSTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTP1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTP1 Gene COMPARTMENTS Subcellular localization image for GSTP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular IDA 18962899
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with GSTP1: view

Pathways for GSTP1 Gene

genes like me logo Genes that share pathways with GSTP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0002674 negative regulation of acute inflammatory response NAS 18962899
GO:0006469 negative regulation of protein kinase activity IDA 16636664
GO:0006749 glutathione metabolic process IDA 1540159
GO:0006805 xenobiotic metabolic process TAS --
genes like me logo Genes that share ontologies with GSTP1: view

Compounds for GSTP1 Gene

(12) HMDB Compounds for GSTP1 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(20) Drugbank Compounds for GSTP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
target
2-(N-Morpholino)-Ethanesulfonic Acid
target
Busulfan
  • Busulphan
55-98-1 enzyme substrate
Carboplatin
  • CBDCA
41575-94-4 enzyme substrate
Carboxymethylenecysteine
target

(131) Novoseek inferred chemical compound relationships for GSTP1 Gene

Compound -log(P) Hits PubMed IDs
gsts 95.3 104
1-chloro-24-dinitrobenzene 84.8 26
ethacrynic acid 80.8 25
epoxide 77 50
s-hexylglutathione 70.4 1

(8) PharmGKB related drug/compound annotations for GSTP1 Gene

genes like me logo Genes that share compounds with GSTP1: view

Transcripts for GSTP1 Gene

mRNA/cDNA for GSTP1 Gene

Unigene Clusters for GSTP1 Gene

Glutathione S-transferase pi 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for GSTP1 Gene

GeneLoc Exon Structure for
GSTP1
ECgene alternative splicing isoforms for
GSTP1

Expression for GSTP1 Gene

mRNA expression in normal human tissues for GSTP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTP1 Gene

This gene is overexpressed in Esophagus - Mucosa (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTP1 Gene

SOURCE GeneReport for Unigene cluster for GSTP1 Gene Hs.523836

genes like me logo Genes that share expressions with GSTP1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GSTP1 Gene

Orthologs for GSTP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTP1 35
  • 99.68 (n)
  • 99.52 (a)
GSTP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTP1 35
  • 87.78 (n)
  • 86.19 (a)
GSTP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
GSTP1 35
  • 86.83 (n)
  • 87.14 (a)
GSTP1 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia BC021614 36
  • 70 (a)
OneToMany
Gstp1 35
  • 83.49 (n)
  • 85.24 (a)
Gstp1 16
Gstp1 36
  • 85 (a)
OneToMany
Gstp2 36
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GSTP1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gstp1 35
  • 82.7 (n)
  • 85.71 (a)
lizard
(Anolis carolinensis)
Reptilia GSTP1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstp1 35
  • 57.26 (n)
  • 55.98 (a)
zebrafish
(Danio rerio)
Actinopterygii gstp1 35
  • 63.14 (n)
  • 60.58 (a)
gstp1 36
  • 61 (a)
OneToMany
gstp2 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 36
  • 39 (a)
ManyToMany
gst-23 36
  • 38 (a)
ManyToMany
gst-25 36
  • 35 (a)
ManyToMany
gst-1 37
  • 39 (a)
Species with no ortholog for GSTP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTP1 Gene

ENSEMBL:
Gene Tree for GSTP1 (if available)
TreeFam:
Gene Tree for GSTP1 (if available)

Paralogs for GSTP1 Gene

Paralogs for GSTP1 Gene

Selected SIMAP similar genes for GSTP1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GSTP1 Gene

genes like me logo Genes that share paralogs with GSTP1: view

Variants for GSTP1 Gene

Sequence variations from dbSNP and Humsavar for GSTP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1695 - 67,585,218(+) AATAC(A/G)TCTCC reference, missense
rs4891 -- 67,586,499(+) CTCAG(C/T)GCCCG synonymous-codon, reference
rs643317 -- 67,582,986(-) CATGT(A/G)GAGGA upstream-variant-2KB
rs643318 -- 67,582,985(-) ATGTA(C/G)AGGAT upstream-variant-2KB
rs675554 -- 67,585,679(-) ACACA(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTP1 Gene

Variant ID Type Subtype PubMed ID
nsv897801 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
esv2422195 CNV Duplication 17116639
dgv1196n71 CNV Loss 21882294
nsv897815 CNV Loss 21882294
nsv468606 CNV Gain 19166990

Relevant External Links for GSTP1 Gene

HapMap Linkage Disequilibrium report
GSTP1
Human Gene Mutation Database (HGMD)
GSTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTP1 Gene

Disorders for GSTP1 Gene

(92) Novoseek inferred disease relationships for GSTP1 Gene

Disease -log(P) Hits PubMed IDs
cancer 65.4 112
prostate cancer 61.4 171
tumors 59.2 150
prostatic intraepithelial neoplasia 57 11
cancer lung 52.7 87

Relevant External Links for GSTP1

Genetic Association Database (GAD)
GSTP1
Human Genome Epidemiology (HuGE) Navigator
GSTP1
genes like me logo Genes that share disorders with GSTP1: view

No data available for UniProtKB/Swiss-Prot for GSTP1 Gene

Publications for GSTP1 Gene

  1. Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. (PMID: 11040079) Juronen E. … Mikelsaar A.V. (Exp. Eye Res. 2000) 3 23 48
  2. No association between the I105V polymorphism of the glutathione S-transferase P1 gene (GSTP1) and prostate cancer risk: a prospective study. (PMID: 11097238) Shepard T.F. … Giovannucci E. (Cancer Epidemiol. Biomarkers Prev. 2000) 3 23 48
  3. Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype. (PMID: 11159743) Spurdle A.B. … Chenevix-Trench G. (Carcinogenesis 2001) 3 23 48
  4. Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier. (PMID: 11169956) Maugard C.M. … Ali-Osman F. (Int. J. Cancer 2001) 3 23 48
  5. Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma. (PMID: 11131031) Steinhoff C. … Schulz W.A. (Arch. Toxicol. 2000) 3 23 48

Products for GSTP1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GSTP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GSTP1
    • Block miRNA regulation of GSTP1 using miScript Target Protectors

    Sources for GSTP1 Gene

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