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GSTP1 Gene

protein-coding   GIFtS: 75
GCID: GC11P067351

Glutathione S-Transferase Pi 1


(Previous symbols: FAEES3, GST3)
  See GSTP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glutathione S-Transferase Pi 11 2     GSTP2
GST31 2 3 5     HEL-S-222
FAEES31 2 3     PI2
GSTP1-12 3     Deafness, X-Linked 72
GST Class-Pi2 3     Epididymis Secretory Protein Li 222
EC 2.5.1.183 8     Fatty Acid Ethyl Ester Synthase III2
DFN72     Glutathione S-Transferase P2

External Ids:    HGNC: 46381   Entrez Gene: 29502   Ensembl: ENSG000000842077   OMIM: 1346605   UniProtKB: P092113   
ORGUL members:         

Export aliases for GSTP1 gene to outside databases

Previous GC identifers: GC11P069874 GC11P069047 GC11P067601 GC11P067126 GC11P067107 GC11P063681


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTP1 Gene:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by
catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on
their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes:
alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different
GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to
cancer, and other diseases. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTP1 Gene:
GSTP1 (glutathione S-transferase pi 1) is a protein-coding gene. Diseases associated with GSTP1 include maxillary sinus squamous cell carcinoma, and barrett's esophagus. GO annotations related to this gene include kinase regulator activity and glutathione transferase activity. An important paralog of this gene is GSTM4.

UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration

Gene Wiki entry for GSTP1 Gene

PharmGKB "VIP" summary for GSTP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTP1 gene promoter:
         Sp1   p53   AP-1   MyoD   c-Jun   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): GSTP1 promoter sequence
   Search Chromatin IP Primers for GSTP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

GSTP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067351:  view genomic region     (about GC identifiers)

Start:
67,351,066 bp from pter      End:
67,354,131 bp from pter
Size:
3,066 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211 (See protein sequence)
Recommended Name: Glutathione S-transferase P  
Size: 210 amino acids; 23356 Da
Subunit: Homodimer. Interacts with CDK5
Selected PDB 3D structures from and Proteopedia for GSTP1 (see all 53):
10GS (3D)        11GS (3D)        12GS (3D)        13GS (3D)        14GS (3D)        16GS (3D)    
Secondary accessions: O00460 Q15690 Q5TZY3

Explore the universe of human proteins at neXtProt for GSTP1: NX_P09211

Explore proteomics data for GSTP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys55, Lys121, Lys128, Lys191
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTP1 (P09211) (see all 8)
     RMLLADQ  GLYGKDQ  ISFADYNL  FPLLSAYV 


    See GSTP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000843.1  
    ENSEMBL proteins: 
     ENSP00000381607   ENSP00000381604  
    Reactome Protein details: P09211

    GSTP1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant GSTP1 Protein
    R&D Systems Recombinant & Natural Proteins for GSTP1 (Glutathione S-Transferase pi 1/GSTP1)
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    OriGene MassSpec for GSTP1
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    GenScript Custom Purified and Recombinant Proteins Services for GSTP1
    Novus Biologicals GSTP1 Proteins
    Novus Biologicals GSTP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTP1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GSTP1 

     
    antibodies-online proteins for GSTP1 (43 products) 

     
    antibodies-online peptides for GSTP1

    GSTP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSTP1
    R&D Systems Antibodies for GSTP1 (Glutathione S-Transferase/GST, Glutathione S-Transferase pi 1/GSTP1)
    Cell Signaling Technology (CST) Antibodies for GSTP1 
    OriGene Antibodies for GSTP1
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    Novus Biologicals GSTP1 Antibodies
    Abcam antibodies for GSTP1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GSTP1
    antibodies-online antibodies for GSTP1 (174 products) 

    GSTP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GSTP1
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    GenScript Custom Assay Services for GSTP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GSTP1 
    antibodies-online kits for GSTP1 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003082 GST_pi
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P09211

    ProtoNet protein and cluster: P09211

    3 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB003082 Pi-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTP1_HUMAN, P09211
    Similarity: Belongs to the GST superfamily. Pi family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTP1_HUMAN, P09211
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTP1:
    glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the esophagus and in
    Barrett's esophagus carcinoma,involved in the DNA methylation of cpG island in prostate cancer and other cancer

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA1540159
    GO:0005515protein binding IPI16636664
    GO:0008432JUN kinase binding ISS--
    GO:0019207kinase regulator activity ISS--
    GO:0035730S-nitrosoglutathione binding IDA11533048
         
    Find genes that share ontologies with GSTP1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for GSTP1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gstp1):
     growth/size/body  integument  tumorigenesis 

    Find genes that share phenotypes with GSTP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GSTP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSTP1:
    hsa-mir-133a-3p (MIRT021715), hsa-mir-92a-3p (MIRT049201), hsa-mir-513a-3p (MIRT006966), hsa-mir-26b-5p (MIRT029320)

    Block miRNA regulation of human, mouse, rat GSTP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GSTP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTP1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTP1

    Clone
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    OriGene clones in human, mouse for GSTP1 (see all 7)
    OriGene ORF clones in mouse, rat for GSTP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTP1 (NM_000852)
    Sino Biological Human cDNA Clone for GSTP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTP1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for GSTP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTP1_HUMAN, P09211: Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un
    uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    cytoskeleton1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005622intracellular IDA18962899
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with GSTP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTP1 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione metabolism0.65
    4-hydroxy-2-nonenal detoxification0.00
    Glutathione conjugation0.60
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    Acetaminophen metabolism0.00
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    4Cellular Senescence
    Cellular responses to stress0.81
    5Glioma
    Prostate cancer0.39


    Find genes that share SuperPaths with GSTP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for GSTP1
        MAP Kinase Signaling
    Cell Cycle / Checkpoint Control
    Neuroscience

    4 GeneGo (Thomson Reuters) Pathways for GSTP1
        Naphthalene metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism
    Glutathione metabolism

    5 BioSystems Pathways for GSTP1
        Diurnally regulated genes with circadian orthologs
    Arachidonate Epoxygenase / Epoxide Hydrolase
    glutathione-mediated detoxification I
    metapathway biotransformation
    4-hydroxy-2-nonenal detoxification


    2 Reactome Pathways for GSTP1
        Detoxification of Reactive Oxygen Species
    Glutathione conjugation

    5 PharmGKB Pathways for GSTP1
        Acetaminophen Pathway, Pharmacokinetics
    Busulfan Pathway, Pharmacodynamics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GSTP1) (see all 6):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Pathways in cancer
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTP1 (see all 12): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSTP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTP1 (P092111, 2, 3 ENSP000003816074) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNO1Q9NRX12, 3MINT-63446 I2D: score=5 
    PTNP212462, 3MINT-63445 I2D: score=5 
    TRAF2Q129331, 3, ENSP000002476684EBI-353467,EBI-355744 I2D: score=3 STRING: ENSP00000247668
    MAPK8P459833, ENSP000003534834I2D: score=3 STRING: ENSP00000353483
    MAP3K5Q996833, ENSP000003519084I2D: score=2 STRING: ENSP00000351908
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ISS--
    GO:0002674negative regulation of acute inflammatory response NAS18962899
    GO:0006469negative regulation of protein kinase activity IDA16636664
    GO:0006749glutathione metabolic process IDA1540159
    GO:0006805xenobiotic metabolic process TAS--

    Find genes that share ontologies with GSTP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTP1

    Selected HMDB Compounds for GSTP1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    Selected DrugBank Compounds for GSTP1 (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carboxymethylenecysteine-- --target--17139284 17016423 10592235
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetinhibitor15094841 11899840 10592235
    Glutathione Sulfonic Acid-- --target--17139284 17016423 10592235
    S-(P-Nitrobenzyl)Glutathione-- --target--17139284 17016423 10592235
    S-Hexylglutathione-- --target--17139284 17016423 10592235
    (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene-- --target--17139284 17016423
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--17139284 17016423
    ChlorambucilChlocambucil (see all 9)305-03-3enzymesubstrate18511072 14527828
    Cibacron Blue-- 84166-13-2target--17139284 17016423
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17465221 17517071

    Selected Novoseek inferred chemical compound relationships for GSTP1 gene (see all 131)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 95.3 121 2241927 (4), 10744731 (2), 9425104 (2), 8330352 (1) (see all 99)
    1-chloro-24-dinitrobenzene 84.8 37 2241148 (2), 16316931 (2), 7864646 (1), 16539699 (1) (see all 24)
    ethacrynic acid 80.8 35 9776312 (4), 15911318 (4), 1988111 (2), 9463521 (2) (see all 17)
    epoxide 77 54 1958232 (4), 15668107 (2), 9255563 (1), 11122850 (1) (see all 46)
    s-hexylglutathione 70.4 1 8343114 (1)
    7-chloro-4-nitrobenzo-2-oxa-1,3-diazole 65.6 2 8074309 (1), 1906885 (1)
    gamma-glutamylcysteine 65.2 16 18571892 (2), 7903354 (1), 10762637 (1), 15960885 (1) (see all 13)
    maleylacetoacetate 64.1 1 18096758 (1)
    sulforaphane 63.8 12 18204073 (4), 10814878 (1), 16778223 (1), 9298252 (1) (see all 7)
    brostallicin 63 5 19950984 (4), 16111802 (1)

    8 PharmGKB related drug/compound annotations for GSTP1 gene    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  
    cisplatinCA  
    cyclophosphamideCA  
    epirubicinCA  
    fluorouracilCA  
    methotrexateCA  
    oxaliplatinCA  
    thiotepaCA  



    Find genes that share compounds with GSTP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GSTP1 gene: 
    NM_000852.3  

    Unigene Cluster for GSTP1:

    Glutathione S-transferase pi 1
    Hs.523836  [show with all ESTs]
    Unigene Representative Sequence: BM926728
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398606(uc001omf.3) ENST00000398603 ENST00000494593 ENST00000464930
    ENST00000476137 ENST00000489040 ENST00000498765 ENST00000467591 ENST00000495996

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate GSTP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GSTP1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTP1
    Clone
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    OriGene clones in human, mouse for GSTP1 (see all 7)
    OriGene ORF clones in mouse, rat for GSTP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTP1 (NM_000852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTP1
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      QuantiTect SYBR Green Assays in human, mouse, rat GSTP1
      QuantiFast Probe-based Assays in human, mouse, rat GSTP1

    Additional mRNA sequence: 

    AY579414.1 AY887902.1 BC010915.1 BT019949.1 BT019950.1 CR450361.1 GQ141553.1 GQ141554.1 
    M69113.1 U30897.1 U62589.1 X06547.1 X15480.1 

    24 DOTS entries:

    DT.453439  DT.92464365  DT.100859245  DT.91737048  DT.40269464  DT.95350104  DT.120691548  DT.91850149 
    DT.95276282  DT.91697086  DT.120691553  DT.95301344  DT.100045398  DT.100646438  DT.120691496  DT.120691528 
    DT.86840764  DT.92357926  DT.95276284  DT.95276285  DT.95276286  DT.95338386  DT.99988672  DT.97856143 

    Selected AceView cDNA sequences (see all 1260):

    BM758558 BE378961 BM758090 AW163051 AL120947 AA300278 BM910764 BM758609 
    CR621327 BM758983 BM747198 CA946272 CD674801 BM551510 AV709921 BM757996 
    BG471997 BU680999 BM758014 F35598 BM743495 BM921734 BM663430 BM832142 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                          -     -                                       
    SP2:                          -     -                                       
    SP3:                          -     -           -                           
    SP4:                          -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for GSTP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GSTP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCCTAGC
    GSTP1 Expression
    About this image


    GSTP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    GSTP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523836
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTP1 (see all 12): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstp11 , 5 glutathione S-transferase, pi 11, 5 83.49(n)1
    85.24(a)1
      19 (3.75 cM)5
    148701  NM_013541.11  NP_038569.11 
     40354115 
    lizard
    (Anolis carolinensis)
    Reptilia GSTP16
    glutathione S-transferase pi 1
    67(a)
    1 ↔ 1
    1(90652114-90682030)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gstp11 glutathione S-transferase pi 1 57.26(n)
    55.98(a)
      549395  NM_001016641.2  NP_001016641.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gstp12 glutathione S-transferase pi 71.29(n)   79381  AF285098.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-13 glutathione S-transferase 39(a)   III(9130970-9131912)   --


    ENSEMBL Gene Tree for GSTP1 (if available)
    TreeFam Gene Tree for GSTP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTP1 gene
    GSTM42  GSTM12  GSTM32  GSTM52  GSTM22  
    8 SIMAP similar genes for GSTP1 using alignment to 6 protein entries:     GSTP1_HUMAN (see all proteins):
    GSTM1    GSTM3    GSTM2    GSTM4    GSTA3    GSTA1
    GSTA2    GSTM5

    Find genes that share paralogs with GSTP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GSTP1
    PGOHUM00000239808


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTP1 (see all 231)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865977911,2
    --63678236(+) ACGCCC/TTAGTC 1 -- us2k10--------
    rs1894391391,2
    --67268782(+) AGTGCA/GTGCAC 1 -- us2k10--------
    rs1132797041,2
    C--67268814(+) GTGATTCTAGTA 
    GTCTAG
    /-
    TCTAG
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1820214281,2
    --67268819(+) TTCTAA/GTTTCG 1 -- us2k10--------
    rs362113991,2
    C--67268820(+) CTAGT-/AGTCT 
    AGTCTAGT
    TTCGC
    1 -- us2k10--------
    rs1865514531,2
    C--67268894(+) CTGTTC/TGTGCA 1 -- us2k10--------
    rs2002572801,2
    C--67268938(+) GCTGG-/TTTTTA 1 -- us2k10--------
    rs79493941,2
    C,F,A,H--67268944(+) ttttaC/Tggctc 1 -- us2k1 tfbs34Minor allele frequency- T:0.09NA WA CSA EA 126
    rs79495871,2
    C,F,A,H--67268971(+) cctgcG/Agacat 1 -- us2k17Minor allele frequency- A:0.30WA CSA NA EA 365
    rs65912551,2
    C,F,A--67269172(+) atttcT/Agtttt 1 -- us2k111Minor allele frequency- A:0.32NS NA WA CSA EA 541

    HapMap Linkage Disequilibrium report for GSTP1 (67351066 - 67354131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GSTP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422195CNV Duplication17116639
    dgv1194n71CNV Loss21882294
    nsv897815CNV Loss21882294
    nsv897801CNV Loss21882294
    dgv1196n71CNV Loss21882294
    nsv468606CNV Gain19166990

    Human Gene Mutation Database (HGMD): GSTP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTP1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134660    OMIM disorders: --

    16 diseases for GSTP1:    
    About MalaCards
    maxillary sinus squamous cell carcinoma    barrett's esophagus    bladder cancer susceptibility    cardia cancer
    plasmodium vivax malaria    exfoliation syndrome    oral cancer    epstein-barr virus-associated gastric carcinoma
    hereditary pancreatitis    eclampsia    diffuse gastric cancer    pre-eclampsia
    multiple chemical sensitivity    lung cancer    prostate cancer    breast cancer

    8 diseases from the University of Copenhagen DISEASES database for GSTP1:
    Prostate cancer     Carcinoma     Lung cancer     Breast cancer
    Colorectal cancer     Urinary bladder cancer     Asthma     Esophageal cancer

    Find genes that share disorders with GSTP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GSTP1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 65.4 142 15126784 (4), 9511178 (3), 12576869 (3), 10692562 (2) (see all 99)
    prostate cancer 61.4 194 15649863 (5), 10022813 (5), 19143011 (5), 11549474 (4) (see all 89)
    tumors 59.2 281 9635537 (5), 16527261 (5), 18425080 (5), 15126784 (4) (see all 99)
    prostatic intraepithelial neoplasia 57 12 11549474 (1), 11857497 (1), 12845678 (1), 11550208 (1) (see all 11)
    cancer lung 52.7 104 15105047 (6), 19240225 (5), 11004766 (4), 19282111 (4) (see all 46)
    carcinoma squamous cell 52.5 32 19750576 (2), 11037818 (2), 16982972 (2), 11783067 (2) (see all 28)
    genetic susceptibility 48.7 5 17696749 (2), 15466980 (1), 12497653 (1), 12172904 (1)
    gastric cancer 46.8 40 20377137 (4), 19247656 (3), 7857716 (2), 16615268 (2) (see all 26)
    prostate carcinoma 46.1 30 15623627 (3), 16446401 (2), 9184779 (2), 11085508 (2) (see all 18)
    bladder cancer 46 39 11061940 (5), 18979064 (3), 8311448 (2), 16849682 (2) (see all 18)

    Genetic Association Database (GAD): GSTP1
    Human Genome Epidemiology (HuGE) Navigator: GSTP1 (884 documents)

    Export disorders for GSTP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTP1 gene, integrated from 10 sources (see all 2233):
    (articles sorted by number of sources associating them with GSTP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. (PubMed id 11081456)1, 4, 7 Peters U....Lamprecht-Dinnesen A. (Anticancer Drugs 2000)
    2. The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer. (PubMed id 12148855)1, 4, 9 Kelders W.P....Manni J.J. (Laryngoscope 2002)
    3. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. (PubMed id 19143011)1, 4, 9 Mo Z....Jian L. (Prostate 2009)
    4. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility. (PubMed id 17428572)1, 4, 9 Yang M....Lee J.S. (Lung Cancer 2007)
    5. The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene. (PubMed id 17643058)1, 4, 9 Kamada F....Suzuki Y. (Int. Arch. Allergy Immunol. 2007)
    6. Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India. (PubMed id 16631467)1, 4, 9 Sobti R.C....Nakahara A. (Cancer Genet. Cytogenet. 2006)
    7. I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. (PubMed id 12010858)1, 4, 9 JerA^nimo C....Sidransky D. (amp 2002)
    8. Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. (PubMed id 19254954)1, 2, 9 Okamura T.... Ali-Osman F. (J. Biol. Chem. 2009)
    9. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. (PubMed id 19240225)1, 4, 9 Cote M.L....Taioli E. (Am. J. Epidemiol. 2009)
    10. [Transferase S-glutathione class pi gene (GSTP1) polymorphism in thyroid cancer patients]. (PubMed id 17133316)1, 4, 9 Marciniak P....SowiA8ski J. (Endokrynol Pol 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2950 HGNC: 4638 AceView: GSTP1 Ensembl:ENSG00000084207 euGenes: HUgn2950
    ECgene: GSTP1 Kegg: 2950 H-InvDB: GSTP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSTP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gstp1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTP1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTP1 gene:
    Search GeneIP for patents involving GSTP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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