Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GSTO2 Gene

Aliases for GSTO2 Gene

  • Glutathione S-Transferase Omega 2 2 3
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 2-2 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 64
  • GSTO 2-2 3 4
  • GSTO-2 3 4
  • BA127L20.1 (Novel Glutathione-S-Transferase) 3
  • Glutathione-S-Transferase-Like Protein 3
  • Glutathione S-Transferase Omega-2 3
  • EC 1.20.4.2 4
  • BA127L20.1 3
  • EC 1.8.5.1 4

External Ids for GSTO2 Gene

Summaries for GSTO2 Gene

Entrez Gene Summary for GSTO2 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO2 Gene

GSTO2 (Glutathione S-Transferase Omega 2) is a Protein Coding gene. Diseases associated with GSTO2 include barretts adenocarcinoma. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO1.

UniProtKB/Swiss-Prot for GSTO2 Gene

  • Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

Gene Wiki entry for GSTO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO2 Gene

Genomics for GSTO2 Gene

Genomic Location for GSTO2 Gene

Start:
104,268,416 bp from pter
End:
104,304,948 bp from pter
Size:
36,533 bases
Orientation:
Plus strand

Genomic View for GSTO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO2 Gene

Regulatory Elements for GSTO2 Gene

Proteins for GSTO2 Gene

  • Protein details for GSTO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Y5-GSTO2_HUMAN
    Recommended name:
    Glutathione S-transferase omega-2
    Protein Accession:
    Q9H4Y5
    Secondary Accessions:
    • A8K771
    • B4DJW6
    • E7ESD6
    • Q49TW5
    • Q5GM70
    • Q5JU15
    • Q86WP3

    Protein attributes for GSTO2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28254 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GSTO2 Gene

    Alternative splice isoforms for GSTO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO2 Gene

Proteomics data for GSTO2 Gene at MOPED

Selected DME Specific Peptides for GSTO2 Gene

Post-translational modifications for GSTO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTO2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GSTO2 Gene

Gene Families for GSTO2 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

UniProtKB/Swiss-Prot:

GSTO2_HUMAN
Domain:
  • Contains 1 GST C-terminal domain.:
    • Q9H4Y5
  • Contains 1 GST N-terminal domain.:
    • Q9H4Y5
Family:
  • Belongs to the GST superfamily. Omega family.:
    • Q9H4Y5
genes like me logo Genes that share domains with GSTO2: view

Function for GSTO2 Gene

Molecular function for GSTO2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:15970797};
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot CatalyticActivity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
UniProtKB/Swiss-Prot CatalyticActivity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
UniProtKB/Swiss-Prot Function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

Enzyme Numbers (IUBMB) for GSTO2 Gene

Gene Ontology (GO) - Molecular Function for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0009055 electron carrier activity --
GO:0015035 protein disulfide oxidoreductase activity --
GO:0016491 oxidoreductase activity IDA 15970797
genes like me logo Genes that share ontologies with GSTO2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GSTO2 Gene

Localization for GSTO2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTO2 Gene COMPARTMENTS Subcellular localization image for GSTO2 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GSTO2: view

Pathways for GSTO2 Gene

SuperPathways for GSTO2 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Chemical carcinogenesis
3 Glutathione metabolism
4 Biological oxidations
5 Disease
genes like me logo Genes that share pathways with GSTO2: view

Pathways by source for GSTO2 Gene

Gene Ontology (GO) - Biological Process for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0019852 L-ascorbic acid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GSTO2: view

Compounds for GSTO2 Gene

(12) HMDB Compounds for GSTO2 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(1) Drugbank Compounds for GSTO2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target

(2) Novoseek inferred chemical compound relationships for GSTO2 Gene

Compound -log(P) Hits PubMed IDs
gsts 82.4 2
1-chloro-24-dinitrobenzene 57.1 1
genes like me logo Genes that share compounds with GSTO2: view

Transcripts for GSTO2 Gene

Unigene Clusters for GSTO2 Gene

Glutathione S-transferase omega 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2:
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7: - - - - - - -

Relevant External Links for GSTO2 Gene

GeneLoc Exon Structure for
GSTO2
ECgene alternative splicing isoforms for
GSTO2

Expression for GSTO2 Gene

mRNA expression in normal human tissues for GSTO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTO2 Gene

This gene is overexpressed in Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GSTO2 Gene

SOURCE GeneReport for Unigene cluster for GSTO2 Gene Hs.203634

mRNA Expression by UniProt/SwissProt for GSTO2 Gene

Q9H4Y5-GSTO2_HUMAN
Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis.
genes like me logo Genes that share expressions with GSTO2: view

Orthologs for GSTO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTO2 36
  • 99.18 (n)
  • 98.35 (a)
GSTO2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTO2 36
  • 86.5 (n)
  • 85.12 (a)
GSTO2 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSTO2 36
  • 88.98 (n)
  • 87.03 (a)
GSTO2 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsto2 36
  • 84.36 (n)
  • 83.95 (a)
Gsto2 16
Gsto2 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GSTO2 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gsto2 36
  • 86.42 (n)
  • 85.19 (a)
chicken
(Gallus gallus)
Aves GSTO1 37
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gsto2 36
  • 59.2 (n)
  • 49.79 (a)
zebrafish
(Danio rerio)
Actinopterygii gsto1 37
  • 48 (a)
ManyToMany
gsto2 37
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6662 37
  • 31 (a)
ManyToMany
CG6673 37
  • 30 (a)
ManyToMany
CG6776 37
  • 35 (a)
ManyToMany
se 37
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C02D5.4 37
  • 30 (a)
ManyToMany
gst-44 37
  • 32 (a)
ManyToMany
gsto-1 37
  • 30 (a)
ManyToMany
gsto-2 37
  • 30 (a)
ManyToMany
gsto-3 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
CSA.3044 37
  • 34 (a)
ManyToMany
Species with no ortholog for GSTO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO2 Gene

ENSEMBL:
Gene Tree for GSTO2 (if available)
TreeFam:
Gene Tree for GSTO2 (if available)

Paralogs for GSTO2 Gene

Paralogs for GSTO2 Gene

Selected SIMAP similar genes for GSTO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSTO2: view

Variants for GSTO2 Gene

Sequence variations from dbSNP and Humsavar for GSTO2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs156697 - 104,279,427(-) CAGAT(C/T)AGTGC intron-variant, reference, missense
rs156698 -- 104,298,703(-) AATAA(C/T)TTCTA intron-variant
rs156699 -- 104,293,883(-) TTCTC(C/T)GACTA intron-variant
rs157076 -- 104,288,536(-) ATGAA(C/G)TCTCC intron-variant
rs157077 -- 104,278,136(-) GAGTG(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTO2 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV Gain 17160897

Relevant External Links for GSTO2 Gene

HapMap Linkage Disequilibrium report
GSTO2
Human Gene Mutation Database (HGMD)
GSTO2

Disorders for GSTO2 Gene

(1) MalaCards Diseases for GSTO2 Gene

Search for GSTO2 Gene in MalaCards »

(3) Novoseek inferred disease relationships for GSTO2 Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 32.9 2
ovarian cancer 32.4 5
alzheimers disease 4.85 2

Relevant External Links for GSTO2

Genetic Association Database (GAD)
GSTO2
Human Genome Epidemiology (HuGE) Navigator
GSTO2
genes like me logo Genes that share disorders with GSTO2: view

No data available for UniProtKB/Swiss-Prot for GSTO2 Gene

Publications for GSTO2 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread A.K. … Board P.G. (Pharmacogenetics 2003) 2 3 4 23 25
  2. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PMID: 18398695) Masoudi M. … Saadat M. (Mol. Biol. Rep. 2009) 3 23 49
  3. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. (PMID: 18414634) De Chaudhuri S. … Giri A.K. (Environ. Health Perspect. 2008) 3 23 49
  4. Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer. (PMID: 16761626) Pongstaporn W. … Petmitr S. (J. Exp. Clin. Cancer Res. 2006) 3 23 49
  5. Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients. (PMID: 16788846) Morari E.C. … Ward L.S. (J. Cancer Res. Clin. Oncol. 2006) 3 23 49

Products for GSTO2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GSTO2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GSTO2
    • Block miRNA regulation of GSTO2 using miScript Target Protectors

    Sources for GSTO2 Gene

    Back to Top

    Content