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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTO2 Gene

protein-coding   GIFtS: 63
GCID: GC10P106018

Glutathione S-Transferase Omega 2

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione S-Transferase Omega 21 2     EC 2.5.1.183 8
Glutathione S-Transferase Omega 2-22 3     bA127L20.12
Glutathione-Dependent Dehydroascorbate Reductase2 3     BA127L20.1 (Novel Glutathione-S-Transferase)2
Monomethylarsonic Acid Reductase2 3     Glutathione S-Transferase Omega-22
GSTO-22 3     Glutathione-S-Transferase-Like Protein2
GSTO 2-22 3     EC 1.20.4.23
MMA(V) Reductase2 3     EC 1.8.5.13

External Ids:    HGNC: 230641   Entrez Gene: 1193912   Ensembl: ENSG000000656217   OMIM: 6123145   UniProtKB: Q9H4Y53   

Export aliases for GSTO2 gene to outside databases

Previous GC identifers: GC10P106165 GC10P105699 GC10P105693 GC10P099660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTO2 Gene:
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the
metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Jul 2010)

GeneCards Summary for GSTO2 Gene: 
GSTO2 (glutathione S-transferase omega 2) is a protein-coding gene. Diseases associated with GSTO2 include barrett's adenocarcinoma, and parkinson's disease, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO1.

UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
Function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity
and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic
and reduces monomethylarsonic acid (MMA)

Gene Wiki entry for GSTO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTO2 gene promoter:
         HOXA9B   HOXA9   p53   FOXL1   c-Ets-1   AREB6   CREB   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GSTO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.1

GSTO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTO2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P106018:  view genomic region     (about GC identifiers)

Start:
106,028,631 bp from pter      End:
106,059,616 bp from pter
Size:
30,986 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5 (See protein sequence)
Recommended Name: Glutathione S-transferase omega-2  
Size: 243 amino acids; 28254 Da
3 PDB 3D structures from and Proteopedia for GSTO2:
3Q18 (3D)        3Q19 (3D)        3QAG (3D)    
Secondary accessions: A8K771 B4DJW6 E7ESD6 Q49TW5 Q5GM70 Q5JU15 Q86WP3
Alternative splicing: 3 isoforms:  Q9H4Y5-1   Q9H4Y5-2   Q9H4Y5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GSTO2: NX_Q9H4Y5

Explore proteomics data for GSTO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H4Y5

  • 3 DME Specific Peptides for GSTO2 (Q9H4Y5)
     WPWFERL  YSMRFCP  PPGPVPEG 

    GSTO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSTO2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001177942.1  NP_001177943.1  NP_001177944.1  NP_899062.1  

    ENSEMBL proteins: 
     ENSP00000345023   ENSP00000358721   ENSP00000390986   ENSP00000386011   ENSP00000407381  
    Reactome Protein details: Q9H4Y5
    Human Recombinant Protein Products for GSTO2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals GSTO2 Proteins
    Novus Biologicals GSTO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GSTO2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    GSTO2 for ontologies           About GeneDecksing



    GSTO2 Antibody Products: 
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    ThermoFisher Antibody for GSTO2
    LSBio Antibodies in human, mouse, rat for GSTO2 

    Assay Products for GSTO2: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR005442 GST_omega
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9H4Y5

    ProtoNet protein and cluster: Q9H4Y5

    2 Blocks protein domains:
    IPB004045 Glutathione S-transferase
    IPB005442 Omega-class glutathione S-transferase signature


    UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
    Similarity: Belongs to the GST superfamily. Omega family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTO2_HUMAN, Q9H4Y5
    Function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity
    and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic
    and reduces monomethylarsonic acid (MMA)
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Catalytic activity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
    Catalytic activity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
    Biophysicochemical properties: pH dependence: Optimum pH is 7.5;

         Enzyme Numbers (IUBMB): EC 2.5.1.181 2 EC 1.8.5.11 EC 1.20.4.21

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IEA--
    GO:0005515protein binding ----
    GO:0009055electron carrier activity ----
    GO:0015035protein disulfide oxidoreductase activity ----
    GO:0016491oxidoreductase activity IDA15970797
         
    GSTO2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSTO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSTO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTO2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTO2 

    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): GSTO2 (NM_001191015)
    Sino Biological Human cDNA Clone for GSTO2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTO2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GSTO2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione conjugation0.60
    Glutathione metabolism0.67
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    4Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GSTO2
        Glutathione metabolism


    1 GeneGo (Thomson Reuters) Pathway for GSTO2
        Glutathione metabolism

    1 BioSystems Pathway for GSTO2
        metapathway biotransformation


    5/7        Reactome Pathways for GSTO2 (see all 7)
        Metabolism
    Biological oxidations
    Metabolism of vitamins and cofactors
    Glutathione conjugation
    Metabolism of water-soluble vitamins and cofactors


    4         Kegg Pathways  (Kegg details for GSTO2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSTO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for GSTO2 (ENSP000003450234) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0019852L-ascorbic acid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    GSTO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GSTO2 for compounds           About GeneDecksing

    EMD Millipore small molecules for GSTO2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSTO2

    10/12 HMDB Compounds for GSTO2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for GSTO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17226937 17139284 12618591 17016423 16399380

    2 Novoseek inferred chemical compound relationships for GSTO2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 82.4 2 15942673 (1), 18664505 (1)
    1-chloro-24-dinitrobenzene 57.1 1 15942673 (1)

    Search CenterWatch for drugs/clinical trials and news about GSTO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSTO2 gene (4 alternative transcripts): 
    NM_001191013.1  NM_001191014.1  NM_001191015.1  NM_183239.1  

    Unigene Cluster for GSTO2:

    Glutathione S-transferase omega 2
    Hs.203634  [show with all ESTs]
    Unigene Representative Sequence: AK094412
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338595 ENST00000473401 ENST00000477078 ENST00000369707(uc001kyc.3 uc021pxu.1 uc010qqy.2)
    ENST00000467629 ENST00000498052 ENST00000450629 ENST00000401888(uc010qqw.1)
    ENST00000429569

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTO2

    Additional mRNA sequence: 

    AK094412.1 AK291886.1 AK296266.1 AK297522.1 AK300508.1 AY191318.1 AY209189.1 AY350731.1 
    BC023583.2 BC046194.1 BC056918.1 

    7 DOTS entries:

    DT.100738546  DT.312180  DT.95313878  DT.95369232  DT.75121234  DT.99970936  DT.408349 

    24/83 AceView cDNA sequences (see all 83):

    BC056918 BI828488 BC046194 BF149153 AA627595 BC023583 BQ286824 BQ217819 
    AY191318 BE293581 NM_183239 AI268328 BU930632 BQ270162 BU947426 AI830897 
    CA424150 AI620233 BU169434 BE908662 BI046855 BG490500 BU742752 BU786215 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -                       -     -     -     -     -     -                     
    SP2:                                                                                                            
    SP3:                          -     -                                                                           
    SP4:                                                        -     -     -     -     -     -                     
    SP5:                                                                          -     -                           


    ECgene alternative splicing isoforms for GSTO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTO2 expression in normal human tissues (normalized intensities)      GSTO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAAGAGCA
    GSTO2 Expression
    About this image


    GSTO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor W10
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See GSTO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSTO2

    SOURCE GeneReport for Unigene cluster: Hs.203634

    UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
    Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate.
    Strongest expression in the testis

        SABiosciences Expression via Pathway-Focused PCR Array including GSTO2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GSTO2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsto21 , 5 glutathione S-transferase omega 21, 5 84.36(n)1
    83.95(a)1
      19 (40.41 cM)5
    682141  NM_026619.21  NP_080895.21 
     478655455 
    chicken
    (Gallus gallus)
    Aves GSTO16
    Uncharacterized protein
    58(a)
    1 → many
    6(23780498-23789333)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    3(41577873-41589423)
    zebrafish
    (Danio rerio)
    Actinopterygii gsto16
    gsto26
    glutathione S-transferase omega 2
    48(a)
    48(a)
    many ↔ many
    many ↔ many
    13(25604322-25612941)
    13(25620786-25626662)
    fruit fly
    (Drosophila melanogaster)
    Insecta se6
    CG67766
    (see all 4)
    --
    35(a)
    33(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3L(8513652-8514589)
    3L(8511985-8513395)
    worm
    (Caenorhabditis elegans)
    Secernentea gsto-31 Protein GSTO-3 43.32(n)
    38.07(a)
      175196  NM_171061.1  NP_741069.1 


    ENSEMBL Gene Tree for GSTO2 (if available)
    TreeFam Gene Tree for GSTO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTO2 gene
    GSTO12  
    1 SIMAP similar gene for GSTO2 using alignment to 3 protein entries:     GSTO2_HUMAN (see all proteins):
    GSTO1

    GSTO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/702 SNPs in GSTO2 are shown (see all 702)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7033461,2
    C,A--99671679(-) ttttgT/Gcagtc 4 -- int11Minor allele frequency- G:0.00NA 2
    rs112797101,2
    C--106030516(+) CCAGT-/CCAGT 
            
    TTCTG
    2 -- int10--------
    rs577784971,2
    C--106033039(+) TGTCTT/-CTCCA 4 -- int1 us2k11Minor allele frequency- -:0.50CSA 2
    rs355288731,2
    C,F--106045963(+) GAGCGT/-TTTTT 4 -- int13Minor allele frequency- -:0.50NA CSA 6
    rs344937031,2
    C--106051887(+) ACAAA-/AGACAG 4 -- int12Minor allele frequency- A:0.25NA 4
    rs1916302071,2
    --106388891(+) TTGGAC/TGATAG 2 -- us2k10--------
    rs171167541,2
    C,F,H--106388893(+) GGACGA/TTAGAG 2 -- us2k121Minor allele frequency- T:0.18NA NS EA WA CSA 1883
    rs171167551,2
    C,F,H--106388908(+) TCAGGG/CTTACT 2 -- us2k1 tfbs321Minor allele frequency- C:0.17NA NS EA WA CSA 1879
    rs171167581,2
    C,F,H--106389082(+) CTCTAT/CAGTGT 2 -- us2k117Minor allele frequency- C:0.20NA NS EA WA CSA 1461
    rs580899811,2
    C,F--106389149(+) AAGGGA/GAAAAA 2 -- us2k14Minor allele frequency- G:0.15WA CSA 601

    HapMap Linkage Disequilibrium report for GSTO2 (106028631 - 106059616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831971CNV Gain17160897


    Human Gene Mutation Database (HGMD): GSTO2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612314    OMIM disorders: --

    20 diseases for GSTO2:    About MalaCards
    barrett's adenocarcinoma    parkinson's disease    chronic obstructive pulmonary disease    ovarian cancer
    cytochrome p450    alzheimer's disease    huntington's disease    acute lymphoblastic leukemia
    acute myeloid leukemia    lymphoblastic leukemia    cataract    myeloid leukemia
    asthma    gastric cancer    adenocarcinoma    leukemia
    hepatocellular carcinoma    colorectal cancer    breast cancer    prostatitis


    GSTO2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for GSTO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 32.9 2 15917099 (1), 15040808 (1)
    ovarian cancer 32.4 6 16761626 (3), 16788846 (2)
    alzheimers disease 4.85 2 15917099 (2)

    Genetic Association Database (GAD): GSTO2
    Human Genome Epidemiology (HuGE) Navigator: GSTO2 (38 documents)

    Export disorders for GSTO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTO2 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with GSTO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PubMed id 12618591)1, 2, 3, 7, 9 Whitbread A.K.... Board P.G. (2003)
    2. Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer. (PubMed id 16761626)1, 4, 9 Pongstaporn W....Petmitr S. (2006)
    3. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PubMed id 18398695)1, 4, 9 Masoudi M....Saadat M. (2008)
    4. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PubMed id 19430957)1, 4, 9 Rafiee L....Saadat M. (2009)
    5. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes. (PubMed id 18414634)1, 4, 9 De Chaudhuri S....Giri A.K. (2008)
    6. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. (PubMed id 15917099)1, 4, 9 Ozturk A....Kamboh M.I. (2005)
    7. Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. (PubMed id 15040808)1, 4, 9 Arning L....Epplen J.T. (2004)
    8. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PubMed id 20367187)1, 4, 9 Piacentini S....Fuciarelli M. (2010)
    9. Lack of association of glutathione-S-transferase omeg a 1(A140D) and omega 2 (N142D) gene polymorphisms with urinary arsenic profile and oxidative stress status in arsenic-exposed population. (PubMed id 19635583)1, 4, 9 Xu Y....Sun G. (2009)
    10. Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients. (PubMed id 16788846)1, 4, 9 Morari E.C....Ward L.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 119391 HGNC: 23064 AceView: GSTO2 Ensembl:ENSG00000065621 euGenes: HUgn119391
    ECgene: GSTO2 Kegg: 119391 H-InvDB: GSTO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSTO2 gene:
    Search GeneIP for patents involving GSTO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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