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GSTO2 Gene

protein-coding   GIFtS: 60

GC10P106018
glutathione S-transferase omega 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 2.5.1.18 3
GSTO-2 3
OTTHUMP00000020440 2
bA127L20.1 2
Descriptions
bA127L20.1 (novel glutathione-S-transferase) 2
glutathione S-transferase omega 2 2
glutathione-S-transferase-like protein 2
External Ids
HGNC: 230641
Entrez Gene: 1193912
UniProtKB: Q9H4Y53
Ensembl: ENSG000000656217
Search outside databases for aliases for GSTO2 gene

Previous GC identifers: GC10P106165 GC10P105699 GC10P105693

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GSTO2:
The omega class glutathione transferases (GST; EC 2.5.1.18) have poor activity with common GST
substrates, but exhibit novel glutathione-dependent thioltransferase, dehydroascorbate reductase,
and monomethylarsonate reductase activities, and they modulate Ca(2+) release by ryanodine
receptors (e.g., RYR1, MIM 180901) (Whitbread et al., 2003 [PubMed 12618591]). For background
information on GSTs, see MIM 605482.[supplied by OMIM]

Gene Wiki entry for GSTO2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GSTO2 gene  

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.1

GSTO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P106018:     (about GC identifiers)

Start:
106,018,621 bp from pter
End:
106,049,166 bp from pter
Size:
30,546 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5 (See protein sequence)
Recommended Name: Glutathione S-transferase omega-2  
Size: 243 amino acids; 28254 Da
Secondary accessions: A8K771 Q49TW5 Q5GM70 Q86WP3

REFSEQ proteins: NP_899062.1  

ENSEMBL proteins: 
ENSP00000386011 ENSP00000345023 ENSP00000358722 ENSP00000358721 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (GSTO2)
Human Recombinant Proteins from Abnova (GSTO2)
              OriGene Purified Recombinant Human Protein: GSTO2 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
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Antibodies for GSTO2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for GSTO2
Browse R&D Systems for Antibodies
Antibodies from Abcam (GSTO2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (GSTO2)
Novus Biologicals Antibodies for GSTO2

Assays for GSTO2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR012335 Thioredoxin_fold
 IPR017933 Glutathione_S_Trfase/Cl_chnl_C
 IPR004045 Glutathione_S-Trfase_N
 IPR005442 GST_omega


   GeneDecks  GSTO2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9H4Y5

ProtoNet protein and cluster: Q9H4Y5

2 Blocks protein families:
IPB004045 Glutathione S-transferase
IPB005442 Omega-class glutathione S-transferase signature


UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
Similarity: Belongs to the GST superfamily. Omega family
Similarity: Contains 1 GST C-terminal domain
Similarity: Contains 1 GST N-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (GSTO2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (GSTO2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_058395

              Applied Biosystems Silencer® siRNAs for GSTO2

              Sigma-Aldrich siRNA for GSTO2  
                     Sigma-Aldrich shRNA for GSTO2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for GSTO2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_183239
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_183239
                                 untagged cDNA clone in CMV expression vector: NM_183239 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_183239

UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
Catalytic activity: RX + glutathione = HX + R-S-glutathione
Enzyme Number (IUBMB): EC 2.5.1.18 

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004364 glutathione transferase activity IEA--
GO:0016740 transferase activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Millipore Pathway for GSTO2
 Glutathione metabolism

   GeneDecks  GSTO2 for the pathways selected above  
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for  GSTO2  (Your Favorite Gene powered by Ingenuity) (see all 6
 Metabolism of Xenobiotics by Cytochrome P450
 Aryl Hydrocarbon Receptor Signaling
 NRF2-mediated Oxidative Stress Response
 Xenobiotic Metabolism Signaling
 Glutathione Metabolism

   GeneDecks  GSTO2 for the pathways selected above  
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3 Kegg Pathways  (Kegg details for GSTO2):
 hsa00480 Glutathione metabolism
 hsa00980 Metabolism of xenobiotics by cytochrome P450
 hsa00982 Drug metabolism - cytochrome P450

   GeneDecks  GSTO2 for the pathways selected above  
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5/50 Interacting proteins for GSTO2 (ENSP000003450233) via UniProtKB, MINT, and/or STRING (see all 50 )
InteractantInteraction Details
GeneCardExternal ID(s)
GSTM2ENSP000003588453STRING (score=.975)
GSTT1ENSP000002489353STRING (score=.973)
GSTM1ENSP000003588383STRING (score=.972)
GSTP1ENSP000001969683STRING (score=.972)
GSTM3ENSP000003543573STRING (score=.967)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008152 metabolic process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for GSTO2 available from Tocris Bioscience
CompoundAction CAS number
Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]
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2 Novoseek chemical compound relationships for GSTO2 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
gsts 77.32 2 15942673 (1), 18664505 (1)
1-chloro-24-dinitrobenzene 60.01 1 15942673 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (GSTO2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (GSTO2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_058395

              Sigma-Aldrich siRNA for GSTO2  
                     Sigma-Aldrich shRNA for GSTO2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_183239  

REFSEQ mRNAs for GSTO2 gene: 

NM_183239.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_183239  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_183239
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_183239
                                 untagged cDNA clone in CMV expression vector: NM_183239 

Additional cDNA sequence: 

AK094412.1 AK291886.1 AK296266.1 AK297522.1 AK300508.1 AY191318.1 AY209189.1 AY350731.1 
BC023583.2 BC046194.1 BC056918.1 

7 DOTS entries:

DT.100738546  DT.312180  DT.95313878  DT.95369232  DT.75121234  DT.99970936  DT.408349 

24/83 AceView cDNA sequences (see all 83 ):

NM_183239 BC023583 AA627595 BC046194 BI828488 BF149153 AY191318 BQ217819 
BC056918 BE293581 BQ286824 AI268328 BG490500 AI620221 BX119720 BQ686947 
BQ270162 BI830642 CA424150 BQ212956 BU742752 BG746392 BM708208 BG193418 

highest scoring ESTs for GSTO2:

AI041976 AA159316 AA159327 AA515606 AA535800 AA676703 AA858210 AA906622 AA970827 AA988014 

Unigene Cluster for GSTO2:

Glutathione S-transferase omega 2
Hs.203634  [show with all ESTs]
Unigene Representative Sequence: AK094412


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 (see all 7 )

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:                          -     -                       -     -     -     -     -     -                     
SP2:                                                                                                            
SP3:                          -     -                                                                           
SP4:                                                        -     -     -     -     -     -                     
SP5:                                                                          -     -                           

About this scheme

ECgene alternative splicing isoforms for GSTO2

4 Ensembl transcripts including schematic representations:
ENST00000401888  ENST00000338595  ENST00000369708  ENST00000369707  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GSTO2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for GSTO2

1 / 2 / 3

3 probe-sets matching GSTO2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
45609_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI041976 1.00 1.00 1.00 1

227163_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

227163_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  GSTO2 for binary patterns associated with the probe-sets selected above  
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About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GATAAGAGCA

SOURCE GeneReport for Unigene cluster: Hs.203634

UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle
and prostate. Strongest expression in the testis

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for GSTO2 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
GSTO21   -- glutathione S-transferase omega 2 89.35(n)
87.11(a)
477814  XM_535008.2  XP_535008.2 
chimpanzee
(Pan troglodytes)
GSTO21   -- glutathione S-transferase omega 2 99.18(n)
98.35(a)
450720  XM_001138494.1  XP_001138494.1 
cow
(Bos taurus)
GSTO21   -- glutathione S-transferase omega 2 86.5(n)
85.12(a)
613905  XM_865110.2  XP_870203.1 
rat
(Rattus norvegicus)
Gsto21   -- glutathione S-transferase omega 2 86.42(n)
85.19(a)
309465  NM_001012071.1  NP_001012071.1 
mouse
(Mus musculus)
Gsto21, 5 195
glutathione S-transferase omega 21, 5 84.22(n)1
83.54(a)1
682141  NM_026619.11  NP_080895.11 
 AK0189535  AK0195825  (see all 8)
About this table        Species with no ortholog for GSTO2

ENSEMBL Gene Tree for GSTO2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for GSTO2 gene
GSTO12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/233 NCBI SNPs in GSTO2 are shown (see all 233 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 166)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs6410711,2
A,C,F,H,O106018147(-) GTGAGC/AAACCC 1 -- ng515Minor allele frequency- A:0.42NA MN WA 814
rs1566971,2
A,C,F,H,O106029175(-) CAGATT/CAGTGC 1 D/N mis130Minor allele frequency- C:0.40MN EA NS NA EU WA 3568
rs105097691,2
A,C,F,H106018060(+) AATTCT/CGCCTA 1 -- ng5113Minor allele frequency- C:0.09NS EU EA WA NA 1140
rs22972351,2
C,F,H,O106024481(+) GTTAAA/GTTACC 1 -- ut518Minor allele frequency- G:0.22EA NA EU 2392
rs122646461,2
A,C,F,H106017892(+) TTGGCC/ACTGAA 1 -- ng519Minor allele frequency- A:0.09EU EA WA NA 1522
rs122648441,2
C,F,H106018240(+) GGTCCC/TGAGGT 1 -- ng515Minor allele frequency- T:0.09EU EA WA 896
rs171167701,2
C,F,H106018719(+) CACAGC/GCAACC 1 -- ut51 ese38Minor allele frequency- G:0.09NA EU EA WA 1038
rs4944311,2
C,F,H106018956(-) AGGATT/AGGCGG 1 -- ut51 ese39Minor allele frequency- A:0.05EA NA EU WA 1426
rs171168481,2
C,F,H106049643(+) ATTATT/GGGTGC 1 -- ng318Minor allele frequency- G:0.04NA EU EA WA 1040
--
rs122194701,2
C,F106049338(+) cccgcC/Ttcagc 1 -- ng311Minor allele frequency- T:0.09--480
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HapMap Linkage Disequilibrium images for GSTO2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612314

3 Novoseek disease relationships for GSTO2 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease 37.54 2 15917099 (1), 15040808 (1)
ovarian cancer 24.76 6 16761626 (3), 16788846 (2)
alzheimers disease 9.95 2 15917099 (2)
About this table

Genetic Association Database: GSTO2
Human Genome Epidemiology Navigator: GSTO2 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/33 PubMed articles for GSTO2 gene (see all 33 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 119391 HGNC: 23064 AceView: GSTO2 Ensembl:ENSG00000065621 euGenes: HUgn119391
ECgene: GSTO2 H-InvDB: GSTO2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for GSTO2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GSTO2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for GSTO2 Antibodies for GSTO2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for GSTO2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (GSTO2)
 Antibodies (GSTO2)
 Chimera RNAi (GSTO2)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(GSTO2)
 Antibodies (GSTO2)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Tocris compounds for GSTO2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for GSTO2

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