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GSTO2 Gene

protein-coding   GIFtS: 62
GCID: GC10P106018

Glutathione S-Transferase Omega 2

  See GSTO2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Omega 21 2     EC 2.5.1.183 8
Glutathione S-Transferase Omega 2-22 3     bA127L20.12
Glutathione-Dependent Dehydroascorbate Reductase2 3     BA127L20.1 (Novel Glutathione-S-Transferase)2
Monomethylarsonic Acid Reductase2 3     Glutathione S-Transferase Omega-22
GSTO-22 3     Glutathione-S-Transferase-Like Protein2
GSTO 2-22 3     EC 1.20.4.23
MMA(V) Reductase2 3     EC 1.8.5.13

External Ids:    HGNC: 230641   Entrez Gene: 1193912   Ensembl: ENSG000000656217   OMIM: 6123145   UniProtKB: Q9H4Y53   

Export aliases for GSTO2 gene to outside databases

Previous GC identifers: GC10P106165 GC10P105699 GC10P105693 GC10P099660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTO2 Gene:
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the
metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Jul 2010)

GeneCards Summary for GSTO2 Gene:
GSTO2 (glutathione S-transferase omega 2) is a protein-coding gene. Diseases associated with GSTO2 include barrett's adenocarcinoma, and parkinson's disease. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO1.

UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
Function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity
and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic
and reduces monomethylarsonic acid (MMA)

Gene Wiki entry for GSTO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTO2 gene promoter:
         HOXA9B   HOXA9   p53   FOXL1   c-Ets-1   AREB6   CREB   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GSTO2 promoter sequence
   Search Chromatin IP Primers for GSTO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.1

GSTO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTO2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P106018:  view genomic region     (about GC identifiers)

Start:
106,028,631 bp from pter      End:
106,064,703 bp from pter
Size:
36,073 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5 (See protein sequence)
Recommended Name: Glutathione S-transferase omega-2  
Size: 243 amino acids; 28254 Da
3 PDB 3D structures from and Proteopedia for GSTO2:
3Q18 (3D)        3Q19 (3D)        3QAG (3D)    
Secondary accessions: A8K771 B4DJW6 E7ESD6 Q49TW5 Q5GM70 Q5JU15 Q86WP3
Alternative splicing: 3 isoforms:  Q9H4Y5-1   Q9H4Y5-2   Q9H4Y5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GSTO2: NX_Q9H4Y5

Explore proteomics data for GSTO2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for GSTO2 (Q9H4Y5)
     WPWFERL  YSMRFCP  PPGPVPEG 


    See GSTO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177942.1  NP_001177943.1  NP_001177944.1  NP_899062.1  

    ENSEMBL proteins: 
     ENSP00000345023   ENSP00000358721   ENSP00000390986   ENSP00000386011   ENSP00000407381  
    Reactome Protein details: Q9H4Y5

    GSTO2 Human Recombinant Protein Products:

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    antibodies-online proteins for GSTO2 (7 products) 

     
    antibodies-online peptides for GSTO2

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    antibodies-online kits for GSTO2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    4 InterPro protein domains:
     IPR005442 GST_omega
     IPR012336 Thioredoxin-like_fold
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9H4Y5

    ProtoNet protein and cluster: Q9H4Y5

    2 Blocks protein domains:
    IPB004045 Glutathione S-transferase
    IPB005442 Omega-class glutathione S-transferase signature


    UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
    Similarity: Belongs to the GST superfamily. Omega family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTO2_HUMAN, Q9H4Y5
    Function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity
    and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic
    and reduces monomethylarsonic acid (MMA)
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Catalytic activity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
    Catalytic activity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
    Biophysicochemical properties: pH dependence: Optimum pH is 7.5;

         Enzyme Numbers (IUBMB): EC 2.5.1.181 2 EC 1.8.5.11 EC 1.20.4.21

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IEA--
    GO:0005515protein binding ----
    GO:0009055electron carrier activity ----
    GO:0015035protein disulfide oxidoreductase activity ----
    GO:0016491oxidoreductase activity IDA15970797
         
    Find genes that share ontologies with GSTO2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GSTO2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GSTO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTO2 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with GSTO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GSTO2
        Glutathione metabolism

    1 BioSystems Pathway for GSTO2
        metapathway biotransformation


    2 Reactome Pathways for GSTO2
        Glutathione conjugation
    Vitamin C (ascorbate) metabolism


    4 Kegg Pathways  (Kegg details for GSTO2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including GSTO2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GSTO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTO2 (ENSP000003450234) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0019852L-ascorbic acid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with GSTO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTO2

    Selected HMDB Compounds for GSTO2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for GSTO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17226937 17139284 12618591 17016423 16399380

    2 Novoseek inferred chemical compound relationships for GSTO2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 82.4 2 15942673 (1), 18664505 (1)
    1-chloro-24-dinitrobenzene 57.1 1 15942673 (1)



    Find genes that share compounds with GSTO2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GSTO2 gene (4 alternative transcripts): 
    NM_001191013.1  NM_001191014.1  NM_001191015.1  NM_183239.1  

    Unigene Cluster for GSTO2:

    Glutathione S-transferase omega 2
    Hs.203634  [show with all ESTs]
    Unigene Representative Sequence: AK094412
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338595 ENST00000473401 ENST00000477078 ENST00000369707(uc001kyc.3 uc021pxu.1 uc010qqy.2)
    ENST00000467629 ENST00000498052 ENST00000450629 ENST00000401888(uc010qqw.1)
    ENST00000429569
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    Additional mRNA sequence: 

    AK094412.1 AK291886.1 AK296266.1 AK297522.1 AK300508.1 AY191318.1 AY209189.1 AY350731.1 
    BC023583.2 BC046194.1 BC056918.1 

    7 DOTS entries:

    DT.100738546  DT.312180  DT.95313878  DT.95369232  DT.75121234  DT.99970936  DT.408349 

    Selected AceView cDNA sequences (see all 83):

    BE293581 BC023583 BC046194 BQ286824 BF149153 BQ217819 BI828488 AI268328 
    BC056918 AY191318 AA627595 NM_183239 AK094412 BE773323 BG193418 BU786215 
    BM708208 BG330793 BG749471 AI749754 BE249901 BU742752 BQ216419 BQ901068 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -                       -     -     -     -     -     -                     
    SP2:                                                                                                            
    SP3:                          -     -                                                                           
    SP4:                                                        -     -     -     -     -     -                     
    SP5:                                                                          -     -                           


    ECgene alternative splicing isoforms for GSTO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAAGAGCA
    GSTO2 Expression
    About this image


    GSTO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    GSTO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203634

    UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5
    Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate.
    Strongest expression in the testis

        Pathway & Disease-focused RT2 Profiler PCR Array including GSTO2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTO2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsto21 , 5 glutathione S-transferase omega 21, 5 84.36(n)1
    83.95(a)1
      19 (40.41 cM)5
    682141  NM_026619.21  NP_080895.21 
     478655455 
    chicken
    (Gallus gallus)
    Aves GSTO16
    Gallus gallus glutathione S-transferase omega 1 (G...
    59(a)
    1 → many
    6(23780498-23789333)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    3(41577873-41589423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gsto21 glutathione S-transferase omega 2 59.2(n)
    49.79(a)
      448662  NM_001005086.2  NP_001005086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gsto16
    gsto26
    glutathione S-transferase omega 2
    48(a)
    48(a)
    many ↔ many
    many ↔ many
    13(25604322-25612941) ENSDARG00000022183
    13(25620786-25626662) ENSDARG00000033285
    fruit fly
    (Drosophila melanogaster)
    Insecta se6
    CG67766
    (see all 4)
    --
    37(a)
    35(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3L(8513652-8514589)
    3L(8511985-8513395)
    worm
    (Caenorhabditis elegans)
    Secernentea gst-446
    gsto-16
    (see all 5)
    Protein GSTO-1 (gsto-1) mRNA, complete cds
    (see all 5)
    32(a)
    30(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    V(16390934-16392406) WBGene00001792
    III(7945157-7947018) WBGene00016204


    ENSEMBL Gene Tree for GSTO2 (if available)
    TreeFam Gene Tree for GSTO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTO2 gene
    GSTO12  
    1 SIMAP similar gene for GSTO2 using alignment to 3 protein entries:     GSTO2_HUMAN (see all proteins):
    GSTO1

    Find genes that share paralogs with GSTO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTO2 (see all 702)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7033461,2
    C,A--99671679(-) ttttgT/Gcagtc 4 -- int11Minor allele frequency- G:0.00NA 2
    rs112797101,2
    C--106030516(+) CCAGT-/CCAGT 
            
    TTCTG
    2 -- int10--------
    rs577784971,2
    C--106033039(+) TGTCTT/-CTCCA 4 -- int1 us2k11Minor allele frequency- -:0.50CSA 2
    rs355288731,2
    C,F--106045963(+) GAGCGT/-TTTTT 4 -- int13Minor allele frequency- -:0.50NA CSA 6
    rs344937031,2
    C--106051887(+) ACAAA-/AGACAG 4 -- int12Minor allele frequency- A:0.25NA 4
    rs1916302071,2
    --106388891(+) TTGGAC/TGATAG 2 -- us2k10--------
    rs171167541,2
    C,F,H--106388893(+) GGACGA/TTAGAG 2 -- us2k121Minor allele frequency- T:0.18NA NS EA WA CSA 1883
    rs171167551,2
    C,F,H--106388908(+) TCAGGG/CTTACT 2 -- us2k1 tfbs321Minor allele frequency- C:0.17NA NS EA WA CSA 1879
    rs171167581,2
    C,F,H--106389082(+) CTCTAT/CAGTGT 2 -- us2k117Minor allele frequency- C:0.20NA NS EA WA CSA 1461
    rs580899811,2
    C,F--106389149(+) AAGGGA/GAAAAA 2 -- us2k14Minor allele frequency- G:0.15WA CSA 601

    HapMap Linkage Disequilibrium report for GSTO2 (106028631 - 106064703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831971CNV Gain17160897

    Human Gene Mutation Database (HGMD): GSTO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTO2
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612314    OMIM disorders: --

    2 diseases for GSTO2:    
    About MalaCards
    barrett's adenocarcinoma    parkinson's disease


    Find genes that share disorders with GSTO2           About GenesLikeMe

    3 Novoseek inferred disease relationships for GSTO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 32.9 2 15917099 (1), 15040808 (1)
    ovarian cancer 32.4 6 16761626 (3), 16788846 (2)
    alzheimers disease 4.85 2 15917099 (2)

    Genetic Association Database (GAD): GSTO2
    Human Genome Epidemiology (HuGE) Navigator: GSTO2 (38 documents)

    Export disorders for GSTO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTO2 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with GSTO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PubMed id 12618591)1, 2, 3, 7, 9 Whitbread A.K.... Board P.G. (Pharmacogenetics 2003)
    2. Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer. (PubMed id 16761626)1, 4, 9 Pongstaporn W....Petmitr S. (amp 2006)
    3. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PubMed id 18398695)1, 4, 9 Masoudi M....Saadat M. (Mol. Biol. Rep. 2009)
    4. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PubMed id 19430957)1, 4, 9 Rafiee L....Saadat M. (Mol. Biol. Rep. 2010)
    5. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. (PubMed id 18414634)1, 4, 9 De Chaudhuri S....Giri A.K. (Environ. Health Perspect. 2008)
    6. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. (PubMed id 15917099)1, 4, 9 Ozturk A....Kamboh M.I. (Neurobiol. Aging 2005)
    7. Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. (PubMed id 15040808)1, 4, 9 Arning L....Epplen J.T. (BMC Med. Genet. 2004)
    8. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PubMed id 20367187)1, 4, 9 Piacentini S....Fuciarelli M. (Ann. Hum. Biol. 2010)
    9. Lack of association of glutathione-S-transferase omega 1(A140D) and omega 2 (N142D) gene polymorphisms with urinary arsenic profile and oxidative stress status in arsenic-exposed population. (PubMed id 19635583)1, 4, 9 Xu Y....Sun G. (Mutat. Res. 2009)
    10. Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients. (PubMed id 16788846)1, 4, 9 Morari E.C....Ward L.S. (J. Cancer Res. Clin. Oncol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 119391 HGNC: 23064 AceView: GSTO2 Ensembl:ENSG00000065621 euGenes: HUgn119391
    ECgene: GSTO2 Kegg: 119391 H-InvDB: GSTO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSTO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTO2 gene:
    Search GeneIP for patents involving GSTO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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