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Aliases for GSTO2 Gene

Aliases for GSTO2 Gene

  • Glutathione S-Transferase Omega 2 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 2-2 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 63
  • GSTO 2-2 3 4
  • GSTO-2 3 4
  • BA127L20.1 (Novel Glutathione-S-Transferase) 3
  • Glutathione-S-Transferase-Like Protein 3
  • EC 1.20.4.2 4
  • BA127L20.1 3
  • EC 1.8.5.1 4

External Ids for GSTO2 Gene

Previous GeneCards Identifiers for GSTO2 Gene

  • GC10P106165
  • GC10P105699
  • GC10P105693
  • GC10P106018
  • GC10P099660

Summaries for GSTO2 Gene

Entrez Gene Summary for GSTO2 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO2 Gene

GSTO2 (Glutathione S-Transferase Omega 2) is a Protein Coding gene. Diseases associated with GSTO2 include parkinson disease, late-onset. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity and protein disulfide oxidoreductase activity. An important paralog of this gene is GSTO1.

UniProtKB/Swiss-Prot for GSTO2 Gene

  • Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

Gene Wiki entry for GSTO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO2 Gene

Genomics for GSTO2 Gene

Regulatory Elements for GSTO2 Gene

Promoters for GSTO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSTO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTO2 Gene

Chromosome:
10
Start:
104,268,416 bp from pter
End:
104,304,948 bp from pter
Size:
36,533 bases
Orientation:
Plus strand

Genomic View for GSTO2 Gene

Genes around GSTO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO2 Gene

Proteins for GSTO2 Gene

  • Protein details for GSTO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Y5-GSTO2_HUMAN
    Recommended name:
    Glutathione S-transferase omega-2
    Protein Accession:
    Q9H4Y5
    Secondary Accessions:
    • A8K771
    • B4DJW6
    • E7ESD6
    • Q49TW5
    • Q5GM70
    • Q5JU15
    • Q86WP3

    Protein attributes for GSTO2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28254 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GSTO2 Gene

    Alternative splice isoforms for GSTO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO2 Gene

Proteomics data for GSTO2 Gene at MOPED

Selected DME Specific Peptides for GSTO2 Gene

Post-translational modifications for GSTO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTO2 Gene

Domains & Families for GSTO2 Gene

Gene Families for GSTO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4Y5

UniProtKB/Swiss-Prot:

GSTO2_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Omega family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO2: view

Function for GSTO2 Gene

Molecular function for GSTO2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:15970797};
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
UniProtKB/Swiss-Prot CatalyticActivity:
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

Enzyme Numbers (IUBMB) for GSTO2 Gene

Gene Ontology (GO) - Molecular Function for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
GO:0016491 oxidoreductase activity IDA 15970797
GO:0050610 methylarsonate reductase activity IEA --
genes like me logo Genes that share ontologies with GSTO2: view
genes like me logo Genes that share phenotypes with GSTO2: view

Animal Models for GSTO2 Gene

MGI Knock Outs for GSTO2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTO2 Gene

Localization for GSTO2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTO2 Gene COMPARTMENTS Subcellular localization image for GSTO2 gene
Compartment Confidence
cytosol 5
extracellular 5
chloroplast 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GSTO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GSTO2 Gene

Pathways & Interactions for GSTO2 Gene

genes like me logo Genes that share pathways with GSTO2: view

Interacting Proteins for GSTO2 Gene

Gene Ontology (GO) - Biological Process for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0019852 L-ascorbic acid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GSTO2: view

No data available for SIGNOR curated interactions for GSTO2 Gene

Drugs & Compounds for GSTO2 Gene

(4) Drugs for GSTO2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Vitamin C Approved Nutra 424,424
dehydroascorbic acid Experimental Pharma 0
Trichloroethylene Pharma 5

(45) Additional Compounds for GSTO2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTO2: view

Transcripts for GSTO2 Gene

Unigene Clusters for GSTO2 Gene

Glutathione S-transferase omega 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2:
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7: - - - - - - -

Relevant External Links for GSTO2 Gene

GeneLoc Exon Structure for
GSTO2
ECgene alternative splicing isoforms for
GSTO2

Expression for GSTO2 Gene

mRNA expression in normal human tissues for GSTO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTO2 Gene

This gene is overexpressed in Testis (x5.5).

Protein differential expression in normal tissues from HIPED for GSTO2 Gene

This gene is overexpressed in Platelet (36.9), Testis (20.0), and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTO2 Gene



SOURCE GeneReport for Unigene cluster for GSTO2 Gene Hs.203634

mRNA Expression by UniProt/SwissProt for GSTO2 Gene

Q9H4Y5-GSTO2_HUMAN
Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis.
genes like me logo Genes that share expression patterns with GSTO2: view

Protein tissue co-expression partners for GSTO2 Gene

Primer Products

In Situ Assay Products

Orthologs for GSTO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTO2 35
  • 99.18 (n)
  • 98.35 (a)
GSTO2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTO2 35
  • 86.5 (n)
  • 85.12 (a)
GSTO2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSTO2 36
  • 59 (a)
OneToOne
GSTO2 35
  • 88.98 (n)
  • 87.03 (a)
mouse
(Mus musculus)
Mammalia Gsto2 16
Gsto2 35
  • 84.36 (n)
  • 83.95 (a)
Gsto2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GSTO2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gsto2 35
  • 86.42 (n)
  • 85.19 (a)
chicken
(Gallus gallus)
Aves GSTO1 36
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gsto2 35
  • 59.2 (n)
  • 49.79 (a)
zebrafish
(Danio rerio)
Actinopterygii gsto1 36
  • 48 (a)
ManyToMany
gsto2 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6662 36
  • 31 (a)
ManyToMany
CG6673 36
  • 30 (a)
ManyToMany
CG6776 36
  • 35 (a)
ManyToMany
se 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C02D5.4 36
  • 30 (a)
ManyToMany
gst-44 36
  • 32 (a)
ManyToMany
gsto-1 36
  • 30 (a)
ManyToMany
gsto-2 36
  • 30 (a)
ManyToMany
gsto-3 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
CSA.3044 36
  • 34 (a)
ManyToMany
Species with no ortholog for GSTO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO2 Gene

ENSEMBL:
Gene Tree for GSTO2 (if available)
TreeFam:
Gene Tree for GSTO2 (if available)

Paralogs for GSTO2 Gene

Paralogs for GSTO2 Gene

(1) SIMAP similar genes for GSTO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSTO2: view

Variants for GSTO2 Gene

Sequence variations from dbSNP and Humsavar for GSTO2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs156697 - 104,279,427(-) CAGAT(C/T)AGTGC intron-variant, reference, missense
rs45582439 - 104,279,392(+) GGAGT(A/G)CCTGG intron-variant, reference, missense
rs276210 -- 104,286,645(-) GATAA(C/T)CAGTT intron-variant, utr-variant-3-prime
rs157078 -- 104,299,182(-) GTGGG(A/G)TCCCA reference, synonymous-codon, missense
rs157079 -- 104,299,020(-) TTGGG(A/G)AGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTO2 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV Gain 17160897

Variation tolerance for GSTO2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTO2 Gene

HapMap Linkage Disequilibrium report
GSTO2
Human Gene Mutation Database (HGMD)
GSTO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO2 Gene

Disorders for GSTO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GSTO2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search GSTO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTO2

Genetic Association Database (GAD)
GSTO2
Human Genome Epidemiology (HuGE) Navigator
GSTO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTO2
genes like me logo Genes that share disorders with GSTO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO2 Gene

Publications for GSTO2 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread A.K. … Board P.G. (Pharmacogenetics 2003) 2 3 4 23 25 26 67
  2. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PMID: 19430957) Rafiee L. … Saadat M. (Mol. Biol. Rep. 2010) 3 23
  3. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova I.E. … Brauch H. (Breast Cancer Res. Treat. 2010) 3 23
  4. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S. … Fuciarelli M. (Ann. Hum. Biol. 2010) 3 23
  5. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PMID: 18398695) Masoudi M. … Saadat M. (Mol. Biol. Rep. 2009) 3 23

Products for GSTO2 Gene

Sources for GSTO2 Gene

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