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Aliases & Descriptions for GSTO2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.5.1.18 3 | | GSTO-2 3 | | OTTHUMP00000020440 2 | | bA127L20.1 2 |
| | | Descriptions |
|---|
| bA127L20.1 (novel glutathione-S-transferase) 2 | | glutathione S-transferase omega 2 2 | | glutathione-S-transferase-like protein 2 |
|
| | Search outside databases for aliases for GSTO2 genePrevious GC identifers: GC10P106165 GC10P105699 GC10P105693 |
Summaries for GSTO2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GSTO2: The omega class glutathione transferases (GST; EC 2.5.1.18) have poor activity with common GST substrates, but exhibit novel glutathione-dependent thioltransferase, dehydroascorbate reductase, and monomethylarsonate reductase activities, and they modulate Ca(2+) release by ryanodine receptors (e.g., RYR1, MIM 180901) (Whitbread et al., 2003 [PubMed 12618591]). For background information on GSTs, see MIM 605482.[supplied by OMIM] Gene Wiki entry for GSTO2 |
Genomic Location for GSTO2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GSTO2 gene 
Entrez Gene cytogenetic band: 10q25.1 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q25.1GSTO2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P106018:
(about GC identifiers)
Start:
|
106,018,621 bp from pter |
End:
|
106,049,166 bp from pter |
Size:
|
30,546 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for GSTO2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5 (See
protein sequence)Recommended Name: Glutathione S-transferase omega-2 Size: 243 amino acids; 28254 Da
Secondary accessions: A8K771 Q49TW5 Q5GM70 Q86WP3REFSEQ proteins: NP_899062.1
ENSEMBL proteins: ENSP00000386011 ENSP00000345023 ENSP00000358722 ENSP00000358721
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: GSTO2 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for GSTO2: Assays for GSTO2: | Protein
Domains/ Families for GSTO2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H4Y5
ProtoNet protein and cluster: Q9H4Y5 2 Blocks protein families: IPB004045 Glutathione S-transferase IPB005442 Omega-class glutathione S-transferase signature
UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5Similarity: Belongs to the GST superfamily. Omega familySimilarity: Contains 1 GST C-terminal domainSimilarity: Contains 1 GST N-terminal domain | Gene Function for GSTO2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_058395
Applied Biosystems Silencer® siRNAs for GSTO2
Sigma-Aldrich siRNA for GSTO2  Sigma-Aldrich shRNA for GSTO2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_183239                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_183239                                  untagged cDNA clone in CMV expression vector: NM_183239 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_183239
UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5Catalytic activity: RX + glutathione = HX + R-S-glutathioneEnzyme Number (IUBMB): EC 2.5.1.18 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004364 | glutathione transferase activity |
IEA | -- | | GO:0016740 | transferase activity |
IEA | -- | About this table | Pathways & Interactions for GSTO2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for GSTO2 (Your Favorite Gene powered by Ingenuity) (see all 6
) 
5/50 Interacting proteins for GSTO2 (ENSP000003450233) via UniProtKB, MINT, and/or STRING (see all 50
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for GSTO2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for GSTO2 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Ellagic acid | Selective inhibitor of CK2. Also inhibits glutathione S-transferase | [476-66-4] | About this table
2 Novoseek chemical compound relationships for GSTO2 gene
About this table
|
Transcripts for GSTO2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_058395
Sigma-Aldrich siRNA for GSTO2  Sigma-Aldrich shRNA for GSTO2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_183239 REFSEQ mRNAs for GSTO2 gene: NM_183239.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_183239               OriGene GFP tagged cDNA clone in CMV expression vector: NM_183239                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_183239                                  untagged cDNA clone in CMV expression vector: NM_183239  Additional cDNA sequence: AK094412.1 AK291886.1 AK296266.1 AK297522.1 AK300508.1 AY191318.1 AY209189.1 AY350731.1 BC023583.2 BC046194.1 BC056918.1 7 DOTS entries: DT.100738546 DT.312180 DT.95313878 DT.95369232 DT.75121234 DT.99970936 DT.408349 24/83 AceView cDNA sequences (see all 83
):NM_183239 BC023583 AA627595 BC046194 BI828488 BF149153 AY191318 BQ217819 BC056918 BE293581 BQ286824 AI268328 BG490500 AI620221 BX119720 BQ686947 BQ270162 BI830642 CA424150 BQ212956 BU742752 BG746392 BM708208 BG193418
highest scoring ESTs for GSTO2:AI041976 AA159316 AA159327 AA515606 AA535800 AA676703 AA858210 AA906622 AA970827 AA988014 Unigene Cluster for GSTO2: Glutathione S-transferase omega 2 Hs.203634 [show with all ESTs]Unigene Representative Sequence: AK094412
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 (see all 7
)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | |
| SP1: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GSTO2
4 Ensembl transcripts including schematic representations: ENST00000401888
ENST00000338595
ENST00000369708
ENST00000369707
|
Expression for GSTO2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GSTO2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GSTO2
1 / 2 / 3 3 probe-sets matching GSTO2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GATAAGAGCA
SOURCE GeneReport for Unigene cluster: Hs.203634 UniProtKB/Swiss-Prot: GSTO2_HUMAN, Q9H4Y5Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis |
Orthologs for GSTO2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GSTO2 gene from 5 species
About this table Species with no ortholog for GSTO2
ENSEMBL Gene Tree for GSTO2 | Paralogs for GSTO2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GSTO2 gene
- GSTO12
|
SNPs/Variants for GSTO2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GSTO2 (up to first 250kb)
|
Disorders & Mutations for GSTO2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612314
3 Novoseek disease relationships for GSTO2 gene
About this table
Genetic Association Database: GSTO2 Human Genome Epidemiology Navigator: GSTO2 (19 documents)
|
Medical News for GSTO2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GSTO2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/33 PubMed articles for GSTO2 gene (see all 33
):- Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PubMed id 12618591)1, 2, 3, 4 Whitbread A.K....Board P.G. (2003)
- Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. (PubMed id 15917099)1, 3, 6 Ozturk A....Kamboh M.I. (2005)
- Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. (PubMed id 15040808)1, 3, 6 Arning L....Epplen J.T. (2004)
- Polymorphism of glutathione S-transferase omega gene and risk of cancer. (PubMed id 15992993)3, 6 Marahatta S.B....Petmitr S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- Cloning, expression and characterization of human glutathione S-transferase Omega 2. (PubMed id 15942673)1, 3 Wang L....Mao Y. (2005)
- Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer. (PubMed id 16761626)1, 3 Pongstaporn W....Petmitr S. (2006)
- Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PubMed id 18398695)1, 3 Masoudi M....Saadat M. (2008)
- Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes. (PubMed id 18414634)1, 3 De Chaudhuri S....Giri A.K. (2008)
|
Search for GSTO2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GSTO2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GSTO2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GSTO2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GSTO2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GSTO2:

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| | | | Tocris compounds for GSTO2 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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