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Aliases for GSTO1 Gene

Aliases for GSTO1 Gene

  • Glutathione S-Transferase Omega 1 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 1-1 3 4
  • S-(Phenacyl)Glutathione Reductase 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 63
  • GSTO 1-1 3 4
  • GSTTLp28 3 4
  • SPG-R 3 4
  • Epididymis Secretory Protein Li 21 3
  • Glutathione-S-Transferase Like 3
  • EC 1.20.4.2 4
  • EC 1.8.5.1 4
  • HEL-S-21 3
  • GSTO-1 4
  • P28 3

External Ids for GSTO1 Gene

Previous GeneCards Identifiers for GSTO1 Gene

  • GC10P106145
  • GC10P105679
  • GC10P106004
  • GC10P099645

Summaries for GSTO1 Gene

Entrez Gene Summary for GSTO1 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO1 Gene

GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Proliferative Type Fibrocystic Change Of Breast and Chondromalacia. Among its related pathways are Phase II conjugation and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot for GSTO1 Gene

  • Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Gene Wiki entry for GSTO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO1 Gene

Genomics for GSTO1 Gene

Regulatory Elements for GSTO1 Gene

Enhancers for GSTO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSTO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTO1 Gene

Chromosome:
10
Start:
104,235,356 bp from pter
End:
104,267,464 bp from pter
Size:
32,109 bases
Orientation:
Plus strand

Genomic View for GSTO1 Gene

Genes around GSTO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO1 Gene

Proteins for GSTO1 Gene

  • Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78417-GSTO1_HUMAN
    Recommended name:
    Glutathione S-transferase omega-1
    Protein Accession:
    P78417
    Secondary Accessions:
    • D3DRA3
    • F5H7H0
    • Q5TA03
    • Q7Z3T2

    Protein attributes for GSTO1 Gene

    Size:
    241 amino acids
    Molecular mass:
    27566 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTO1 Gene

    Alternative splice isoforms for GSTO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO1 Gene

Proteomics data for GSTO1 Gene at MOPED

Selected DME Specific Peptides for GSTO1 Gene

Post-translational modifications for GSTO1 Gene

  • Ubiquitination at Lys 11
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTO1 Gene

Antibody Products

Domains & Families for GSTO1 Gene

Gene Families for GSTO1 Gene

Suggested Antigen Peptide Sequences for GSTO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78417

UniProtKB/Swiss-Prot:

GSTO1_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Omega family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO1: view

Function for GSTO1 Gene

Molecular function for GSTO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:11511179, ECO:0000269 PubMed:17226937};
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
UniProtKB/Swiss-Prot CatalyticActivity:
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Enzyme Numbers (IUBMB) for GSTO1 Gene

Gene Ontology (GO) - Molecular Function for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050610 methylarsonate reductase activity TAS --
genes like me logo Genes that share ontologies with GSTO1: view
genes like me logo Genes that share phenotypes with GSTO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTO1

miRNA for GSTO1 Gene

miRTarBase miRNAs that target GSTO1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTO1 Gene

Localization for GSTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTO1 Gene COMPARTMENTS Subcellular localization image for GSTO1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
chloroplast 2

Gene Ontology (GO) - Cellular Components for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005737 cytoplasm IDA 11511179
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GSTO1: view

Pathways & Interactions for GSTO1 Gene

genes like me logo Genes that share pathways with GSTO1: view

Gene Ontology (GO) - Biological Process for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC 11035031
GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC 11035031
genes like me logo Genes that share ontologies with GSTO1: view

No data available for SIGNOR curated interactions for GSTO1 Gene

Drugs & Compounds for GSTO1 Gene

(9) Drugs for GSTO1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Vitamin E Approved Nutra Enzyme, inhibitor 382,385
Vitamin C Approved Nutra 471,471
dehydroascorbic acid Experimental Pharma 0
LB42708 Pharma Selective FTase inhibitor 0

(49) Additional Compounds for GSTO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTO1 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTO1: view

Transcripts for GSTO1 Gene

Unigene Clusters for GSTO1 Gene

Glutathione S-transferase omega 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - -

Relevant External Links for GSTO1 Gene

GeneLoc Exon Structure for
GSTO1
ECgene alternative splicing isoforms for
GSTO1

Expression for GSTO1 Gene

mRNA expression in normal human tissues for GSTO1 Gene

Protein differential expression in normal tissues from HIPED for GSTO1 Gene

This gene is overexpressed in Liver, secretome (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTO1 Gene



SOURCE GeneReport for Unigene cluster for GSTO1 Gene Hs.190028

mRNA Expression by UniProt/SwissProt for GSTO1 Gene

P78417-GSTO1_HUMAN
Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
genes like me logo Genes that share expression patterns with GSTO1: view

Protein tissue co-expression partners for GSTO1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GSTO1 Gene

Orthologs for GSTO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSTO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSTO1 35
  • 85.48 (n)
  • 83.4 (a)
-- 36
  • 82 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GSTO1 35
  • 86.17 (n)
  • 86.31 (a)
GSTO1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsto1 35
  • 76.94 (n)
  • 72.5 (a)
Gsto1 16
Gsto1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GSTO1 35
  • 99.45 (n)
  • 99.17 (a)
GSTO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsto1 35
  • 80.08 (n)
  • 77.59 (a)
oppossum
(Monodelphis domestica)
Mammalia GSTO1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves GSTO1 35
  • 66.95 (n)
  • 63.18 (a)
GSTO1 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1986 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24164 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16014 35
gsto1 35
  • 62.71 (n)
  • 58.47 (a)
gsto1 36
  • 58 (a)
ManyToMany
gsto2 36
  • 56 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11014 35
African malaria mosquito
(Anopheles gambiae)
Insecta GSTO1 35
  • 48.27 (n)
  • 40.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta se 35
  • 52.61 (n)
  • 46.08 (a)
CG6662 36
  • 31 (a)
ManyToMany
CG6673 36
  • 31 (a)
ManyToMany
CG6776 36
  • 35 (a)
ManyToMany
se 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-44 35
  • 48.38 (n)
  • 41.77 (a)
C02D5.4 36
  • 33 (a)
ManyToMany
gst-44 36
  • 38 (a)
ManyToMany
gsto-1 36
  • 32 (a)
ManyToMany
gsto-2 36
  • 33 (a)
ManyToMany
gsto-3 36
  • 24 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00549 35
  • 48.43 (n)
  • 41.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
CSA.3044 36
  • 35 (a)
ManyToMany
Species with no ortholog for GSTO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO1 Gene

ENSEMBL:
Gene Tree for GSTO1 (if available)
TreeFam:
Gene Tree for GSTO1 (if available)

Paralogs for GSTO1 Gene

Paralogs for GSTO1 Gene

(1) SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GSTO1 Gene

genes like me logo Genes that share paralogs with GSTO1: view

Variants for GSTO1 Gene

Sequence variations from dbSNP and Humsavar for GSTO1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs4925 - 104,263,031(+) CTATG(A/C)TGGCC intron-variant, reference, missense
VAR_024484 -
VAR_026583 -
rs11509436 - 104,259,689(+) CGAGT(C/G)TGCCA reference, missense
rs45529437 - 104,255,223(+) GTTCT(A/C/G)CCCGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GSTO1 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV Gain 17160897

Variation tolerance for GSTO1 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTO1 Gene

Human Gene Mutation Database (HGMD)
GSTO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO1 Gene

Disorders for GSTO1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for GSTO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
proliferative type fibrocystic change of breast
  • fibrocystic change, proliferative type with atypia
chondromalacia
cavernous sinus meningioma
  • meningioma of the cavernous sinus
chondromalacia patellae
  • chondromalacia of patella
cisplatin toxicity
- elite association - COSMIC cancer census association via MalaCards
Search GSTO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTO1

Genetic Association Database (GAD)
GSTO1
Human Genome Epidemiology (HuGE) Navigator
GSTO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTO1
genes like me logo Genes that share disorders with GSTO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO1 Gene

Publications for GSTO1 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread A.K. … Board P.G. (Pharmacogenetics 2003) 2 3 4 23 67
  2. Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients. (PMID: 17617905) Harju T.H. … Kinnula V.L. (Respir. Res. 2007) 3 25 26
  3. Tocopherol esters inhibit human glutathione S-transferase omega. (PMID: 17019444) Sampayo-Reyes A. … Zakharyan R.A. (Acta Biochim. Pol. 2006) 23 25 26
  4. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova I.E. … Brauch H. (Breast Cancer Res. Treat. 2010) 3 23
  5. Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity. (PMID: 20106899) Piaggi S. … Casini A.F. (Carcinogenesis 2010) 3 23

Products for GSTO1 Gene

Sources for GSTO1 Gene

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