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GSTO1 Gene

protein-coding   GIFtS: 69
GCID: GC10P106004

Glutathione S-Transferase Omega 1

  See GSTO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Omega 11 2     GSTTLp282
Glutathione S-Transferase Omega 1-12 3     HEL-S-212
Glutathione-Dependent Dehydroascorbate Reductase2 3     P282
Monomethylarsonic Acid Reductase2 3     Epididymis Secretory Protein Li 212
GSTO-12 3     Glutathione S-Transferase Omega-12
SPG-R2 3     Glutathione-S-Transferase Like2
GSTO 1-12 3     EC 1.20.4.23
MMA(V) Reductase2 3     EC 1.8.5.13
S-(Phenacyl)Glutathione Reductase2 3     GSTTLP283
EC 2.5.1.183 8     

External Ids:    HGNC: 133121   Entrez Gene: 94462   Ensembl: ENSG000001488347   OMIM: 6054825   UniProtKB: P784173   

Export aliases for GSTO1 gene to outside databases

Previous GC identifers: GC10P106145 GC10P105679 GC10P099645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTO1 Gene:
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent
thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics
and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for GSTO1 Gene:
GSTO1 (glutathione S-transferase omega 1) is a protein-coding gene. Diseases associated with GSTO1 include barrett's adenocarcinoma, and vascular dementia. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417
Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has
S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the
biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid

Gene Wiki entry for GSTO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTO1 gene promoter:
         GCNF   Tal-1beta   E47   Arnt   c-Ets-1   CREB   HEN1   GCNF-1   deltaCREB   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTO1 promoter sequence
   Search Chromatin IP Primers for GSTO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.1

GSTO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTO1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P106004:  view genomic region     (about GC identifiers)

Start:
105,995,114 bp from pter      End:
106,027,222 bp from pter
Size:
32,109 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417 (See protein sequence)
Recommended Name: Glutathione S-transferase omega-1  
Size: 241 amino acids; 27566 Da
Subunit: Homodimer
Sequence caution: Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for GSTO1:
1EEM (3D)        3LFL (3D)        3VLN (3D)        4IS0 (3D)    
Secondary accessions: D3DRA3 F5H7H0 Q5TA03 Q7Z3T2
Alternative splicing: 3 isoforms:  P78417-1   P78417-2   P78417-3   

Explore the universe of human proteins at neXtProt for GSTO1: NX_P78417

Explore proteomics data for GSTO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for GSTO1 (P78417)
     WPWFERL  YSMRFCP  PVLENSQ  PPGPVPEG 


    See GSTO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177931.1  NP_001177932.1  NP_004823.1  

    ENSEMBL proteins: 
     ENSP00000358727   ENSP00000406708   ENSP00000405325   ENSP00000358724   ENSP00000441488  
    Reactome Protein details: P78417

    GSTO1 Human Recombinant Protein Products:

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    OriGene MassSpec for GSTO1
    OriGene Custom Protein Services for GSTO1
    GenScript Custom Purified and Recombinant Proteins Services for GSTO1
    Novus Biologicals GSTO1 Proteins
    Novus Biologicals GSTO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTO1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GSTO1 

    GSTO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibodies for GSTO1
    LSBio Antibodies in human, mouse, rat for GSTO1

    GSTO1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GSTO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR005442 GST_omega
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P78417

    ProtoNet protein and cluster: P78417

    2 Blocks protein domains:
    IPB004045 Glutathione S-transferase
    IPB005442 Omega-class glutathione S-transferase signature


    UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417
    Similarity: Belongs to the GST superfamily. Omega family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTO1_HUMAN, P78417
    Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has
    S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the
    biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Catalytic activity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
    Catalytic activity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
    Enzyme regulation: Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro
    2,4-dinitrobenzene (CDNB) and by deoxycholate
    Biophysicochemical properties: pH dependence: Optimum pH is 8;

         Enzyme Numbers (IUBMB): EC 2.5.1.181 2 EC 1.8.5.11 EC 1.20.4.21

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA11511179
    GO:0005515protein binding ----
    GO:0016491oxidoreductase activity IDA11511179
    GO:0045174glutathione dehydrogenase (ascorbate) activity IDA11511179
    GO:0050610methylarsonate reductase activity IEA--
         
    Find genes that share ontologies with GSTO1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GSTO1:
     Decreased homologous recombina  Increased gamma-H2AX phosphory  Increased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gsto1):
     homeostasis/metabolism 

    Find genes that share phenotypes with GSTO1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSTO1:
    hsa-mir-197-3p (MIRT048048), hsa-mir-1 (MIRT023892)

    Block miRNA regulation of human, mouse, rat GSTO1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GSTO1:
    hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTO1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTO1

    Clone
    Products:
         
    OriGene clones in human, mouse for GSTO1 (see all 13)
    OriGene ORF clones in mouse, rat for GSTO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GSTO1 (NM_004832)
    Sino Biological Human cDNA Clone for GSTO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTO1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTO1_HUMAN, P78417: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11511179
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GSTO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTO1 About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    5Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    Find genes that share SuperPaths with GSTO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GSTO1
        Glutathione metabolism

    4 BioSystems Pathways for GSTO1
        Myometrial Relaxation and Contraction Pathways
    arsenate detoxification I (glutaredoxin)
    metapathway biotransformation
    ascorbate recycling (cytosolic)


    2 Reactome Pathways for GSTO1
        Glutathione conjugation
    Vitamin C (ascorbate) metabolism


    4 Kegg Pathways  (Kegg details for GSTO1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTO1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GSTO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTO1 (P784172, 3 ENSP000003587274) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266412, 3MINT-64765 I2D: score=5 
    KAT5Q929932, 3MINT-64767 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-64769 I2D: score=5 
    SETDB1Q150472, 3MINT-64766 I2D: score=5 
    UBA5Q9GZZ93, ENSP000003485654I2D: score=8 STRING: ENSP00000348565
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA11035031
    GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC11035031
    GO:0014810positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC11035031
    GO:0019852L-ascorbic acid metabolic process IDA11511179

    Find genes that share ontologies with GSTO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTO1

    Selected HMDB Compounds for GSTO1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    2 DrugBank Compounds for GSTO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17537474 17617905
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9enzymeinhibitor17019444

    9 Novoseek inferred chemical compound relationships for GSTO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monomethylarsonic acid 79.9 5 12565892 (1), 12928150 (1)
    gsts 76.1 4 12077129 (1), 12565892 (1), 12618591 (1), 18664505 (1)
    arsenate 72.1 5 16097802 (1), 16930657 (1), 17019444 (1), 12928150 (1)
    dehydroascorbic acid 65.7 1 17019444 (1)
    1-chloro-24-dinitrobenzene 54.4 1 12565892 (1)
    isocitrate 52.9 1 17269733 (1)
    arsenite 50.5 3 15761769 (1), 12928150 (1)
    cysteine 7.59 1 12077129 (1)
    serine 0 1 12077129 (1)



    Find genes that share compounds with GSTO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GSTO1 gene (3 alternative transcripts): 
    NM_001191002.1  NM_001191003.1  NM_004832.2  

    Unigene Cluster for GSTO1:

    Glutathione S-transferase omega 1
    Hs.190028  [show with all ESTs]
    Unigene Representative Sequence: BQ224776
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470554 ENST00000493946 ENST00000369713(uc001kya.3) ENST00000445155
    ENST00000432659 ENST00000369710(uc021pxs.1) ENST00000539281(uc021pxr.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat GSTO1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GSTO1:
    hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSTO1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTO1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GSTO1 (NM_004832)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTO1
    Primer
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    OriGene qPCR primer pairs and template standards for GSTO1
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTO1
      QuantiTect SYBR Green Assays in human, mouse, rat GSTO1
      QuantiFast Probe-based Assays in human, mouse, rat GSTO1

    Additional mRNA sequence: 

    AF212303.1 AK313680.1 BC000127.1 BX537431.1 U56250.1 U90313.1 

    18 DOTS entries:

    DT.453363  DT.101984619  DT.121279728  DT.100794425  DT.100794428  DT.419915  DT.120882426  DT.419916 
    DT.92444807  DT.95070237  DT.102822348  DT.99940617  DT.100794424  DT.102822347  DT.121279718  DT.95293471 
    DT.95325638  DT.100654291 

    Selected AceView cDNA sequences (see all 479):

    CF130724 H95145 CB177836 BE251897 BG576348 W38620 BM423622 CB164740 
    BM563092 N50645 CD671972 BG178652 BM451365 BU608193 BM982719 CB164726 
    BU846502 AA774551 AA999673 AA340841 BU628023 AI365293 CA308434 BQ084231 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                -           -                 -                     
    SP2:                                -                             -                     
    SP3:        -     -     -     -     -           -                 -                     
    SP4:                                -           -           -     -                     
    SP5:                                -           -                                       


    ECgene alternative splicing isoforms for GSTO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAGATC
    GSTO1 Expression
    About this image


    GSTO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             Metanephros
     
     Epithelial Cells
             Adult Corneal Superficial Epithelial Cells Corneal Epithelium
    GSTO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190028

    UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417
    Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon,
    blood leukocyte and heart. Lowest expression in brain, placenta and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTO1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTO1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsto11 , 5 glutathione S-transferase omega 11, 5 76.94(n)1
    72.5(a)1
      19 (40.41 cM)5
    148731  NM_010362.21  NP_034492.11 
     478549705 
    chicken
    (Gallus gallus)
    Aves GSTO11 glutathione S-transferase omega 1 66.95(n)
    63.18(a)
      423881  NM_001277375.1  NP_001264304.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    66(a)
    1 → many
    3(41577873-41589423)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241642 Xenopus laevis transcribed sequence with weak similarity more 79.56(n)    BJ092240.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160142 Transcribed sequence with weak similarity to protein more 74.3(n)    CK352355.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta se1 sepia 52.61(n)
    46.08(a)
      38973  NM_139978.4  NP_648235.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-441 gst-44 48.38(n)
    41.77(a)
      184405  NM_074741.3  NP_507142.2 


    ENSEMBL Gene Tree for GSTO1 (if available)
    TreeFam Gene Tree for GSTO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTO1 gene
    GSTO22  
    1 SIMAP similar gene for GSTO1 using alignment to 3 protein entries:     GSTO1_HUMAN (see all proteins):
    GSTO2

    Find genes that share paralogs with GSTO1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GSTO1
    PGOHUM00000238188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTO1 (see all 318)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115094351,2
    C,F--106014766(+) CCGGC-/GGC   
      
    /GGCGC
    ATGTT
    3 -- int15NA EU 552
    rs1132009051,2
    C--106022831(-) AATTA-/CCTCCTCT 3 -- cds1 int10--------
    rs358741371,2
    C--106023510(+) GAAAC-/CTTTTT 3 -- int10--------
    rs1869452931,2
    --106023696(+) TTTAAC/TCATCC 3 -- int10--------
    rs1392659001,2
    C--106023711(+) ATTCC-/TAAGA 
            
    TAAAA
    3 -- int10--------
    rs1495148071,2
    --106023788(+) TGTGTA/GTTCAT 3 -- int10--------
    rs122641961,2
    C,F,A,H--106024029(+) TTTTAT/CATTTC 3 -- int111Minor allele frequency- C:0.19NS EA NA WA CSA 1186
    rs1451015501,2
    C--106024032(+) TATAT-/TTCTTCTT 3 -- int10--------
    rs1823220801,2
    --106024169(+) AATCTA/GAAATG 3 -- int10--------
    rs1873206191,2
    --106024196(+) AAAAAA/TCTATG 3 -- int10--------

    HapMap Linkage Disequilibrium report for GSTO1 (105995114 - 106027222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831971CNV Gain17160897

    Human Gene Mutation Database (HGMD): GSTO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTO1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605482    OMIM disorders: --

    3 diseases for GSTO1:    
    About MalaCards
    barrett's adenocarcinoma    vascular dementia    parkinson's disease


    Find genes that share disorders with GSTO1           About GenesLikeMe

    4 Novoseek inferred disease relationships for GSTO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 37.8 7 15159516 (1), 16399380 (1), 14570706 (1), 15917099 (1) (see all 5)
    alzheimers disease 27.7 8 15917099 (2), 15623683 (1), 14570706 (1), 18427999 (1) (see all 5)
    neurodegenerative diseases 24.7 3 20205472 (1), 18427999 (1)
    cancer 0 6 19148497 (3), 20205472 (1), 20106899 (1)

    Genetic Association Database (GAD): GSTO1
    Human Genome Epidemiology (HuGE) Navigator: GSTO1 (55 documents)

    Export disorders for GSTO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTO1 gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with GSTO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PubMed id 12618591)1, 2, 3, 9 Whitbread A.K.... Board P.G. (Pharmacogenetics 2003)
    2. Identification, characterization, and crystal structure of the Omega class glutathione transferases. (PubMed id 10783391)1, 2, 3 Board P.G....Pandit J. (J. Biol. Chem. 2000)
    3. Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. (PubMed id 15623683)1, 4, 9 KAPlsch H....Heun R. (Neurology 2004)
    4. An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia. (PubMed id 19624857)1, 4, 9 Peddareddygari L.R....Grewal R.P. (BMC Neurol 2009)
    5. Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression. (PubMed id 17717316)1, 4, 9 KAPlsch H....Thal D.R. ( a journal of cerebral circulation 2007)
    6. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. (PubMed id 14570706)1, 4, 9 Li Y.J....Welsh-Bohmer K.A. (Hum. Mol. Genet. 2003)
    7. GSTO polymorphism analysis in thyroid nodules suggest that GSTO1 variants do not influence the risk for malignancy. (PubMed id 15901998)1, 4, 9 Granja F....Ward L.S. (Eur. J. Cancer Prev. 2005)
    8. Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. (PubMed id 15040808)1, 4, 9 Arning L....Epplen J.T. (BMC Med. Genet. 2004)
    9. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. (PubMed id 18414634)1, 4, 9 De Chaudhuri S....Giri A.K. (Environ. Health Perspect. 2008)
    10. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. (PubMed id 15917099)1, 4, 9 Ozturk A....Kamboh M.I. (Neurobiol. Aging 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9446 HGNC: 13312 AceView: GSTO1 Ensembl:ENSG00000148834 euGenes: HUgn9446
    ECgene: GSTO1 Kegg: 9446 H-InvDB: GSTO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSTO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTO1 gene:
    Search GeneIP for patents involving GSTO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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