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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTO1 Gene

protein-coding   GIFtS: 68
GCID: GC10P106004

Glutathione S-Transferase Omega 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione S-Transferase Omega 11 2     EC 2.5.1.183 8
Glutathione S-Transferase Omega 1-12 3     GSTTLp282
Glutathione-Dependent Dehydroascorbate Reductase2 3     P282
Monomethylarsonic Acid Reductase2 3     Glutathione S-Transferase Omega-12
GSTO-12 3     Glutathione-S-Transferase Like2
SPG-R2 3     EC 1.20.4.23
GSTO 1-12 3     EC 1.8.5.13
MMA(V) Reductase2 3     GSTTLP283
S-(Phenacyl)Glutathione Reductase2 3     

External Ids:    HGNC: 133121   Entrez Gene: 94462   Ensembl: ENSG000001488347   OMIM: 6054825   UniProtKB: P784173   

Export aliases for GSTO1 gene to outside databases

Previous GC identifers: GC10P106145 GC10P105679 GC10P099645


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTO1 Gene:
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent
thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics
and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for GSTO1 Gene: 
GSTO1 (glutathione S-transferase omega 1) is a protein-coding gene. Diseases associated with GSTO1 include barrett's adenocarcinoma, and vascular dementia, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417
Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has
S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the
biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid

Gene Wiki entry for GSTO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTO1 gene promoter:
         GCNF   Tal-1beta   E47   Arnt   c-Ets-1   CREB   HEN1   GCNF-1   deltaCREB   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.1

GSTO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTO1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P106004:  view genomic region     (about GC identifiers)

Start:
105,995,114 bp from pter      End:
106,027,222 bp from pter
Size:
32,109 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417 (See protein sequence)
Recommended Name: Glutathione S-transferase omega-1  
Size: 241 amino acids; 27566 Da
Subunit: Homodimer
Subcellular location: Cytoplasm, cytosol
Sequence caution: Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for GSTO1:
1EEM (3D)        3LFL (3D)        3VLN (3D)        4IS0 (3D)    
Secondary accessions: D3DRA3 F5H7H0 Q5TA03 Q7Z3T2
Alternative splicing: 3 isoforms:  P78417-1   P78417-2   P78417-3   

Explore the universe of human proteins at neXtProt for GSTO1: NX_P78417

Explore proteomics data for GSTO1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78417

  • 4 DME Specific Peptides for GSTO1 (P78417)
     WPWFERL  YSMRFCP  PVLENSQ  PPGPVPEG 

    GSTO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSTO1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001177931.1  NP_001177932.1  NP_004823.1  

    ENSEMBL proteins: 
     ENSP00000358727   ENSP00000406708   ENSP00000405325   ENSP00000358724   ENSP00000441488  
    Reactome Protein details: P78417
    Human Recombinant Protein Products for GSTO1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GSTO1
    OriGene Protein Over-expression Lysate for GSTO1
    OriGene MassSpec for GSTO1 
    OriGene Custom Protein Services for GSTO1
    GenScript Custom Purified and Recombinant Proteins Services for GSTO1
    Novus Biologicals GSTO1 Proteins
    Novus Biologicals GSTO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GSTO1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11511179
    GO:0005829cytosol TAS--

    GSTO1 for ontologies           About GeneDecksing



    GSTO1 Antibody Products: 
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    Novus Biologicals GSTO1 Antibodies
    Abcam antibodies for GSTO1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for GSTO1
    LSBio Antibodies in human, mouse, rat for GSTO1 

    Assay Products for GSTO1: 
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    GenScript Custom Assay Services for GSTO1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    5/6 InterPro protein domains (see all 6):
     IPR005442 GST_omega
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry P78417

    ProtoNet protein and cluster: P78417

    2 Blocks protein domains:
    IPB004045 Glutathione S-transferase
    IPB005442 Omega-class glutathione S-transferase signature


    UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417
    Similarity: Belongs to the GST superfamily. Omega family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTO1_HUMAN, P78417
    Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has
    S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the
    biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Catalytic activity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
    Catalytic activity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
    Enzyme regulation: Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro
    2,4-dinitrobenzene (CDNB) and by deoxycholate
    Biophysicochemical properties: pH dependence: Optimum pH is 8;

         Enzyme Numbers (IUBMB): EC 2.5.1.181 2 EC 1.8.5.11 EC 1.20.4.21

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA11511179
    GO:0005515protein binding ----
    GO:0016491oxidoreductase activity IDA11511179
    GO:0045174glutathione dehydrogenase (ascorbate) activity IDA11511179
    GO:0050610methylarsonate reductase activity IEA--
         
    GSTO1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for GSTO1:
     Decreased homologous recombina  Increased gamma-H2AX phosphory  Increased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gsto1):
     homeostasis/metabolism 

    GSTO1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSTO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSTO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTO1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GSTO1:
    hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GSTO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTO1

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of GSTO1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GSTO1 (see all 13)
    OriGene ORF clones in mouse, rat for GSTO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GSTO1 (NM_004832)
    Sino Biological Human cDNA Clone for GSTO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTO1
    Sirion Biotech Customized lentivirus for stable overexpression of GSTO1 
                         Customized lentivirus expression plasmids for stable overexpression of GSTO1 

    Cell Line
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    Search LifeMap BioReagents cell lines for GSTO1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GSTO1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione conjugation0.60
    Glutathione metabolism0.67
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    4Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    5Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GSTO1
        Glutathione metabolism


    1 GeneGo (Thomson Reuters) Pathway for GSTO1
        Glutathione metabolism

    4 BioSystems Pathways for GSTO1
        Myometrial Relaxation and Contraction Pathways
    arsenate detoxification I (glutaredoxin)
    metapathway biotransformation
    ascorbate recycling (cytosolic)


    5/7        Reactome Pathways for GSTO1 (see all 7)
        Metabolism
    Biological oxidations
    Metabolism of vitamins and cofactors
    Glutathione conjugation
    Metabolism of water-soluble vitamins and cofactors


    4         Kegg Pathways  (Kegg details for GSTO1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSTO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for GSTO1 (P784172, 3 ENSP000003587274) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266412, 3MINT-64765 I2D: score=5 
    KAT5Q929932, 3MINT-64767 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-64769 I2D: score=5 
    SETDB1Q150472, 3MINT-64766 I2D: score=5 
    UBA5Q9GZZ93, ENSP000003485654I2D: score=8 STRING: ENSP00000348565
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA11035031
    GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC11035031
    GO:0014810positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC11035031
    GO:0019852L-ascorbic acid metabolic process IDA11511179

    GSTO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GSTO1 for compounds           About GeneDecksing

    EMD Millipore small molecules for GSTO1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSTO1

    10/12 HMDB Compounds for GSTO1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    2 DrugBank Compounds for GSTO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17537474 17617905
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9enzymeinhibitor17019444

    9 Novoseek inferred chemical compound relationships for GSTO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monomethylarsonic acid 79.9 5 12565892 (1), 12928150 (1)
    gsts 76.1 4 12077129 (1), 12565892 (1), 12618591 (1), 18664505 (1)
    arsenate 72.1 5 16097802 (1), 16930657 (1), 17019444 (1), 12928150 (1)
    dehydroascorbic acid 65.7 1 17019444 (1)
    1-chloro-24-dinitrobenzene 54.4 1 12565892 (1)
    isocitrate 52.9 1 17269733 (1)
    arsenite 50.5 3 15761769 (1), 12928150 (1)
    cysteine 7.59 1 12077129 (1)
    serine 0 1 12077129 (1)

    Search CenterWatch for drugs/clinical trials and news about GSTO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSTO1 gene (3 alternative transcripts): 
    NM_001191002.1  NM_001191003.1  NM_004832.2  

    Unigene Cluster for GSTO1:

    Glutathione S-transferase omega 1
    Hs.190028  [show with all ESTs]
    Unigene Representative Sequence: BQ224776
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470554 ENST00000493946 ENST00000369713(uc001kya.3) ENST00000445155
    ENST00000432659 ENST00000369710(uc021pxs.1) ENST00000539281(uc021pxr.1)


    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): GSTO1 (NM_004832)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTO1
    Sirion Biotech Customized lentivirus for stable overexpression of GSTO1 
                         Customized lentivirus expression plasmids for stable overexpression of GSTO1 
    Primer
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    OriGene qPCR primer pairs and template standards for GSTO1
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTO1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSTO1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTO1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTO1

    Additional mRNA sequence: 

    AF212303.1 AK313680.1 BC000127.1 BX537431.1 U56250.1 U90313.1 

    18 DOTS entries:

    DT.453363  DT.101984619  DT.121279728  DT.100794425  DT.100794428  DT.419915  DT.120882426  DT.419916 
    DT.92444807  DT.95070237  DT.102822348  DT.99940617  DT.100794424  DT.102822347  DT.121279718  DT.95293471 
    DT.95325638  DT.100654291 

    24/479 AceView cDNA sequences (see all 479):

    BU071385 BC000127 BM563092 AI365293 CB164740 N50645 AA181235 BG178652 
    N55403 CF130724 CA406042 BQ959456 BQ674981 CA405420 W44698 CD673129 
    BQ682970 H95145 AA182559 CB177461 AA071076 CB177836 AA181810 CA418531 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                -           -                 -                     
    SP2:                                -                             -                     
    SP3:        -     -     -     -     -           -                 -                     
    SP4:                                -           -           -     -                     
    SP5:                                -           -                                       


    ECgene alternative splicing isoforms for GSTO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTO1 expression in normal human tissues (normalized intensities)      GSTO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAGATC
    GSTO1 Expression
    About this image


    GSTO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cholinergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Ureter
             visceral organ   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Bone (Muscoskeletal System)
             sensory organ/ear/inner ear   

    See GSTO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSTO1

    SOURCE GeneReport for Unigene cluster: Hs.190028

    UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417
    Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon,
    blood leukocyte and heart. Lowest expression in brain, placenta and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including GSTO1: 
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              Cellular Stress Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GSTO1 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsto11 , 5 glutathione S-transferase omega 11, 5 76.94(n)1
    72.5(a)1
      19 (40.41 cM)5
    148731  NM_010362.21  NP_034492.11 
     478549705 
    chicken
    (Gallus gallus)
    Aves GSTO11 glutathione S-transferase omega 1 67.22(n)
    63.6(a)
      423881  XM_421747.3  XP_421747.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    66(a)
    1 → many
    3(41577873-41589423)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241642 Xenopus laevis transcribed sequence with weak similarity more 79.56(n)    BJ092240.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160142 Transcribed sequence with weak similarity to protein more 74.3(n)    CK352355.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta se1 sepia 52.55(n)
    46.31(a)
      38973  NM_139978.3  NP_648235.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-446
    C02D5.46
    (see all 5)
    Protein C02D5.4
    (see all 5)
    37(a)
    33(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    V(16390934-16392406)
    III(8552553-8553837)


    ENSEMBL Gene Tree for GSTO1 (if available)
    TreeFam Gene Tree for GSTO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTO1 gene
    GSTO22  
    1 SIMAP similar gene for GSTO1 using alignment to 3 protein entries:     GSTO1_HUMAN (see all proteins):
    GSTO2

    GSTO1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GSTO1
    PGOHUM00000238188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in GSTO1 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0244844
    ----see VAR_0244842 E K mis40--------
    VAR_0265834
    ----see VAR_0265832 A V mis40--------
    rs115094351,2
    C,F--106014766(+) CCGGC-/GGC   
      
    /GGCGC
    ATGTT
    3 -- int15NA EU 552
    rs1132009051,2
    C--106022831(-) AATTA-/CCTCCTCT 3 -- cds1 int10--------
    rs358741371,2
    C--106023510(+) GAAAC-/CTTTTT 3 -- int10--------
    rs1869452931,2
    --106023696(+) TTTAAC/TCATCC 3 -- int10--------
    rs1392659001,2
    C--106023711(+) ATTCC-/TAAGA 
            
    TAAAA
    3 -- int10--------
    rs1495148071,2
    --106023788(+) TGTGTA/GTTCAT 3 -- int10--------
    rs122641961,2
    C,F,A,H--106024029(+) TTTTAT/CATTTC 3 -- int111Minor allele frequency- C:0.19NS EA NA WA CSA 1186
    rs1451015501,2
    C--106024032(+) TATAT-/TTCTTCTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for GSTO1 (105995114 - 106027222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831971CNV Gain17160897


    Human Gene Mutation Database (HGMD): GSTO1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for GSTO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605482    OMIM disorders: --

    20/31 diseases for GSTO1 (see all 31):    About MalaCards
    barrett's adenocarcinoma    vascular dementia    intracranial aneurysm    barrett's esophagus
    parkinson's disease    chronic obstructive pulmonary disease    dementia    thyroid cancer
    alzheimer's disease    cytochrome p450    schizophrenia    huntington's disease
    acute lymphoblastic leukemia    lymphoblastic leukemia    essential hypertension    b-cell lymphomas
    atherosclerosis    ischemia    asthma    hepatitis b


    GSTO1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for GSTO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 37.8 7 15159516 (1), 16399380 (1), 14570706 (1), 15917099 (1) (see all 5)
    alzheimers disease 27.7 8 15917099 (2), 15623683 (1), 14570706 (1), 18427999 (1) (see all 5)
    neurodegenerative diseases 24.7 3 20205472 (1), 18427999 (1)
    cancer 0 6 19148497 (3), 20205472 (1), 20106899 (1)

    Genetic Association Database (GAD): GSTO1
    Human Genome Epidemiology (HuGE) Navigator: GSTO1 (55 documents)

    Export disorders for GSTO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTO1 gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with GSTO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PubMed id 12618591)1, 2, 3, 9 Whitbread A.K.... Board P.G. (2003)
    2. Identification, characterization, and crystal structure of the Omega class glutathione transferases. (PubMed id 10783391)1, 2, 3 Board P.G....Pandit J. (2000)
    3. Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. (PubMed id 15623683)1, 4, 9 Kolsch H....Heun R. (2004)
    4. An analysis of methylenetetrahydrofolate reductase an d glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia. (PubMed id 19624857)1, 4, 9 Peddareddygari L.R....Grewal R.P. (2009)
    5. Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression. (PubMed id 17717316)1, 4, 9 Kolsch H....Thal D.R. (2007)
    6. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. (PubMed id 14570706)1, 4, 9 Li Y.J....Welsh-Bohmer K.A. (2003)
    7. GSTO polymorphism analysis in thyroid nodules suggest that GSTO1 variants do not influence the risk for malignancy. (PubMed id 15901998)1, 4, 9 Granja F....Ward L.S. (2005)
    8. Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. (PubMed id 15040808)1, 4, 9 Arning L....Epplen J.T. (2004)
    9. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes. (PubMed id 18414634)1, 4, 9 De Chaudhuri S....Giri A.K. (2008)
    10. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. (PubMed id 15917099)1, 4, 9 Ozturk A....Kamboh M.I. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9446 HGNC: 13312 AceView: GSTO1 Ensembl:ENSG00000148834 euGenes: HUgn9446
    ECgene: GSTO1 Kegg: 9446 H-InvDB: GSTO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSTO1 gene:
    Search GeneIP for patents involving GSTO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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