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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTO1 Gene

protein-coding GIFtS: 67
GCID: GC10P106004

glutathione S-transferase omega 1

Explore 34 diseases affiliated with
GSTO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutathione S-Transferase Omega 1¹ ²		MMA(V) Reductase² ³
GSTTLp28¹ ²		S-(Phenacyl)Glutathione Reductase² ³
P28¹ ²		EC 2.5.1.18³ ⁸
Glutathione S-Transferase Omega 1-1² ³		Glutathione S-Transferase Omega-1²
Glutathione-Dependent Dehydroascorbate Reductase² ³		Glutathione-S-Transferase Like²
Monomethylarsonic Acid Reductase² ³		EC 1.20.4.2³
GSTO-1² ³		EC 1.8.5.1³
SPG-R² ³		GSTTLP28³
GSTO 1-1² ³

External Ids:	HGNC: 13312¹	Entrez Gene: 9446²	Ensembl: ENSG00000148834⁷	OMIM: 605482⁵	UniProtKB: P78417³

Export aliases for GSTO1 gene to outside databases

Previous GC identifers: GC10P106145 GC10P105679 GC10P099645

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTO1:

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol

transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and

carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417

Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has

S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the

biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid

summary for GSTO1:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTO1 gene promoter:
GCNF Tal-1beta E47 Arnt c-Ets-1 CREB HEN1 GCNF-1 deltaCREB GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTO1 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q25.1

GSTO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTO1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P106004: view genomic region (about GC identifiers)

Start:	105,995,114 bp from pter	End:	106,027,222 bp from pter
Size:	32,109 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417 (See protein sequence)

Recommended Name: Glutathione S-transferase omega-1

Size: 241 amino acids; 27566 Da

Subunit: Homodimer

Subcellular location: Cytoplasm, cytosol

Sequence caution: Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for GSTO1:

1EEM (3D)

3LFL (3D)

3VLN (3D)

Secondary accessions: D3DRA3 F5H7H0 Q5TA03 Q7Z3T2

Alternative splicing: 3 isoforms: P78417-1 P78417-2 P78417-3

Explore the universe of human proteins at neXtProt for GSTO1: NX_P78417

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P78417

4 DME Specific Peptides for GSTO1 (P78417)

WPWFERL

YSMRFCP

PVLENSQ

PPGPVPEG

GSTO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001177931.1 NP_001177932.1 NP_004823.1

ENSEMBL proteins:

ENSP00000358727 ENSP00000406708 ENSP00000405325 ENSP00000358724 ENSP00000441488

Reactome Protein details: P78417
Human Recombinant Protein Products:

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	Novus Biologicals GSTO1 Proteins Novus Biologicals GSTO1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for GSTO1
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11511179
GO:0005829	cytosol	TAS	--

GSTO1 for ontologies About GeneDecksing

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	GenScript Custom Assay Services for GSTO1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTO1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR005442 GST_omega

IPR012336 Thioredoxin-like_fold

IPR004046 GST_C

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR004045 Glutathione_S-Trfase_N

Graphical View of Domain Structure for InterPro Entry P78417

ProtoNet protein and cluster: P78417

2 Blocks protein families:

IPB004045 Glutathione S-transferase

IPB005442 Omega-class glutathione S-transferase signature

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417

Similarity: Belongs to the GST superfamily. Omega family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417

Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has

S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the

biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Catalytic activity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate

Catalytic activity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O

Enzyme regulation: Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene

(CDNB) and by deoxycholate

Biophysicochemical properties: pH dependence: Optimum pH is 8;

Enzyme Numbers (IUBMB): EC 2.5.1.18¹ ² EC 1.8.5.1¹ EC 1.20.4.2¹

miRNA Products:		OriGene 3'-UTR Clone: GSTO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTO1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate GSTO1:
		hsa-miR-1252
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSTO1 (see all 7) OriGene shRNA RFP: GSTO1 OriGene siRNA: GSTO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTO1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for GSTO1

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSTO1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSTO1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): GSTO1 (NM_004832)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GSTO1
		Search LifeMap BioReagents cell lines for GSTO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTO1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IDA	11511179
GO:0016491	oxidoreductase activity	IDA	11511179
GO:0016740	transferase activity	--	--
GO:0045174	glutathione dehydrogenase (ascorbate) activity	IDA	11511179
GO:0050610	methylarsonate reductase activity	IEA	--

GSTO1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for GSTO1:

Decreased homologous recombina

Increased gamma-H2AX phosphory

Increased number of cells in m

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gsto1):

homeostasis/metabolism

GSTO1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

	Glutathione metabolism	1.00			Glutathione metabolism	0.70
	Glutathione metabolism	0.92			Glutathione conjugation	0.50

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Vitamin B5 (pantothenate) metabolism

Metabolism of vitamins and cofactors

0.21

Metabolism of water-soluble vitamins and cofactors

0.21

Vitamin C (ascorbate) metabolism

Vitamin C (ascorbate) metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GSTO1

Glutathione metabolism

1 GeneGo (Thomson Reuters) Pathway for GSTO1

Glutathione metabolism

4 BioSystems Pathways for GSTO1

	Myometrial Relaxation and Contraction Pathways
	arsenate detoxification I (glutaredoxin)
	ascorbate recycling (cytosolic)
	metapathway biotransformation

5/7 Reactome Pathways for GSTO1 (see all 7)

	Metabolism
	Biological oxidations
	Metabolism of vitamins and cofactors
	Glutathione conjugation
	Metabolism of water-soluble vitamins and cofactors

3 Kegg Pathways (Kegg details for GSTO1):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

GSTO1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GSTO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/81 Interacting proteins for GSTO1 (P78417^{2, 3} ENSP00000358727⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 81)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EEF1G	P26641²^,³	MINT-64765 I2D: score=5
KAT5	Q92993²^,³	MINT-64767 I2D: score=5
KIAA1377	Q9P2H0²^,³	MINT-64769 I2D: score=5
SETDB1	Q15047²^,³	MINT-64766 I2D: score=5
UBA5	Q9GZZ9³, ENSP00000348565⁴	I2D: score=8 STRING: ENSP00000348565

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	11035031
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC	11035031
GO:0014810	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	IC	11035031
GO:0019852	L-ascorbic acid metabolic process	IDA	11511179

GSTO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSTO1 for compounds About GeneDecksing

EMD Millipore small molecules for GSTO1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTO1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

10/12 HMDB Compounds for GSTO1 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

2 DrugBank Compounds for GSTO1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17537474 17617905
Vitamin E	alpha-Tocopherol (see all 2)	59-02-9	enzyme	inhibitor	17019444

9 Novoseek chemical compound relationships for GSTO1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
monomethylarsonic acid	79.9	5	12565892 (1), 12928150 (1)
gsts	76.1	4	12077129 (1), 12565892 (1), 12618591 (1), 18664505 (1)
arsenate	72.1	5	16097802 (1), 16930657 (1), 17019444 (1), 12928150 (1)
dehydroascorbic acid	65.7	1	17019444 (1)
1-chloro-24-dinitrobenzene	54.4	1	12565892 (1)
isocitrate	52.9	1	17269733 (1)
arsenite	50.5	3	15761769 (1), 12928150 (1)
cysteine	7.59	1	12077129 (1)
serine	0	1	12077129 (1)

Search CenterWatch for drugs/clinical trials and news about GSTO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTO1 gene (3 alternative transcripts):

NM_001191002.1 NM_001191003.1 NM_004832.2

Unigene Cluster for GSTO1:

Glutathione S-transferase omega 1

Hs.190028 [show with all ESTs]

Unigene Representative Sequence: BQ224776

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000470554 ENST00000493946 ENST00000369713(uc001kya.3) ENST00000445155

ENST00000432659 ENST00000369710(uc021pxs.1) ENST00000539281(uc021pxr.1)

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate GSTO1:
		hsa-miR-1252
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): GSTO1 (NM_004832)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTO1

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GSTO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTO1

Additional cDNA sequence:

AF212303.1 AK313680.1 BC000127.1 BX537431.1 U56250.1 U90313.1

18 DOTS entries:

DT.453363 DT.101984619 DT.121279728 DT.100794425 DT.100794428 DT.419915 DT.120882426 DT.419916

DT.92444807 DT.95070237 DT.102822348 DT.99940617 DT.100794424 DT.102822347 DT.121279718 DT.95293471

DT.95325638 DT.100654291

24/479 AceView cDNA sequences (see all 479):

BU608193 BI862344 CD673129 BM563092 BQ277647 AV704618 BU553440 BU628023

BQ682970 AA722892 BU784623 BQ674981 BM556006 R87180 CA406042 BG031235

BU071385 BG178652 N50645 AA071076 BM048140 BE256630 CF130724 BM910442

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b
SP1:											-				-						-
SP2:											-										-
SP3:			-		-		-		-		-				-						-
SP4:											-				-				-		-
SP5:											-				-

ECgene alternative splicing isoforms for GSTO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAAGATC

About this image

GSTO1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See GSTO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTO1

SOURCE GeneReport for Unigene cluster: Hs.190028

UniProtKB/Swiss-Prot: GSTO1_HUMAN, P78417

Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood

leukocyte and heart. Lowest expression in brain, placenta and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including GSTO1:

Drug Metabolism: Phase II Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTO1

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for GSTO1 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GSTO1¹	glutathione S-transferase omega 1	67.22(n) 63.6(a)		423881 XM_421747.3 XP_421747.1
lizard (Anolis carolinensis)	Reptilia	--	--	66(a)	1 → many	3(41578166-41589227)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24164²	Xenopus laevis transcribed sequence with weak similarity more	79.56(n)		BJ092240.1
zebrafish (Danio rerio)	Actinopterygii	Dr.16014²	Transcribed sequence with weak similarity to protein more	74.3(n)		CK352355.1
fruit fly (Drosophila melanogaster)	Insecta	se¹	sepia	52.55(n) 46.31(a)		38973 NM_139978.3 NP_648235.1
worm (Caenorhabditis elegans)	Secernentea	gst-44⁶ C02D5.4⁶ (see all 5)	Glutathione S-Transferase family member (gst-44) Glutathione S-Transferase, Omega class family memb... (see all 5)	37(a) 32(a) (see all 5)	many ↔ many many ↔ many (see all 5)	V(16390914-16392386) III(8552473-8553757)
thale cress (Arabidopsis thaliana)	eudicotyledons	GSTL1⁶ GSTL3⁶ (see all 3)	Glutathione S-transferase family protein (see all 3)	22(a) 22(a) (see all 3)	possible ortholog possible ortholog (see all 3)	5(630876-632683) 5(632796-635125)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	IN2-1 protein, putative, expressed (see all 3)	23(a) 17(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3(9716188-9718843) 3(9711160-9713985)

ENSEMBL Gene Tree for GSTO1 (if available)
TreeFam Gene Tree for GSTO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GSTO1 gene

GSTO2²

1 SIMAP similar gene for GSTO1 using alignment to 3 protein entries: GSTO1_HUMAN (see all proteins):

GSTO2

GSTO1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for GSTO1
PGOHUM00000238188

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76864047^1,2		--	99643887(+)	`ATGAGG/ATCATA`	1	--	us2k¹		2	CSA WA	120
rs73333272^1,2	C,	--	99644318(+)	`CTAGGC/TAAACA`	3	--	us2k¹		2	WA	120
rs74737757^1,2	F,	--	99644686(+)	`GGGCAG/ATTGGT`	3	--	us2k¹		1	EA	120
rs45535832^1,2	C,F,	--	99645194(+)	`TATGGG/ATTAAA`	3	--	us2k¹		2	--	960
rs45530536^1,2	C,	--	99645587(+)	`GCATTC/TACTGA`	3	--	us2k¹		3	NA	962
rs45507795^1,2	C,	--	99645619(+)	`AAGGAG/TGTCGT`	3	--	us2k¹		3	NA	962
rs17879741^1,2	C	--	99645667(+)	`TGAATC/TTGCAT`	3	--	us2k¹		3	EU NA	48
rs17885679^1,2	C,F,	--	99645760(+)	`TCTTTG/ATCCCA`	3	--	us2k¹ ut5¹		1	NS	48
rs45487498^1,2	C,	--	99646227(+)	`AACTTT/CTGTGT`	3	--	int¹ us2k¹		5	WA CSA	1081
rs45466191^1,2	C,	--	99646264(+)	`CAGCGA/TGATGC`	3	--	ut5¹ int¹		5	NA CSA WA	1082

HapMap Linkage Disequilibrium report for GSTO1 (105995114 - 106027222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GSTO1: --
Human Gene Mutation Database (HGMD): GSTO1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GSTO1 for disorders           About GeneDecksing

OMIM gene information: 605482    OMIM disorders: --

20/34 diseases for GSTO1 (see all 34):    About MalaCards

residual type schizophrenia chronic obstructive pulmonary disease b-cell lymphomas barrett's esophagus

intracranial aneurysm acute lymphoblastic leukemia neurodegenerative disease vascular dementia

lymphoblastic leukemia barrett's adenocarcinoma parkinson's disease pulmonary disease

alzheimer's disease dementia huntington's disease hepatitis b

copd thyroiditis homocysteine hepatocellular carcinoma

4 Novoseek disease relationships for GSTO1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	37.8	7	15159516 (1), 16399380 (1), 14570706 (1), 15917099 (1) (see all 5)
alzheimers disease	27.7	8	15917099 (2), 15623683 (1), 14570706 (1), 18427999 (1) (see all 5)
neurodegenerative diseases	24.7	3	20205472 (1), 18427999 (1)
cancer	0	6	19148497 (3), 20205472 (1), 20106899 (1)

Genetic Association Database (GAD): GSTO1
Human Genome Epidemiology (HuGE) Navigator: GSTO1 (55 documents)

Export disorders for GSTO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GSTO1 gene, integrated from 9 sources (see all 128):
(articles sorted by number of sources associating them with GSTO1)

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Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PubMed id 12618591)^{1, 2, 3, 9} Whitbread A.K.... Board P.G. (2003)
Identification, characterization, and crystal structure of the Omega class glutathione transferases. (PubMed id 10783391)^{1, 2, 3} Board P.G....Pandit J. (2000)
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. (PubMed id 15623683)^{1, 4, 9} Kolsch H....Heun R. (2004)
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. (PubMed id 14570706)^{1, 4, 9} Li Y.J....Welsh-Bohmer K.A. (2003)
GSTO polymorphism analysis in thyroid nodules suggest that GSTO1 variants do not influence the risk for malignancy. (PubMed id 15901998)^{1, 4, 9} Granja F....Ward L.S. (2005)
Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. (PubMed id 15040808)^{1, 4, 9} Arning L....Epplen J.T. (2004)
Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. (PubMed id 15917099)^{1, 4, 9} Ozturk A....Kamboh M.I. (2005)
Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans. (PubMed id 12928150)^{1, 2, 9} Yu L.... Klimecki W.T. (2003)
Novel folding and stability defects cause a deficienc y of human glutathione transferase omega 1. (PubMed id 21106529)^{1, 2} Zhou H....Board P.G. (2011)
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients. (PubMed id 17617905)^{1, 7} Harju T.H....Kinnula V.L. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9446	HGNC: 13312	AceView: GSTO1	Ensembl:ENSG00000148834	euGenes: HUgn9446
ECgene: GSTO1	Kegg: 9446	H-InvDB: GSTO1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GSTO1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GSTO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GSTO1 gene:
Search GeneIP for patents involving GSTO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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glutathione S-transferase omega 1

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GSTO1 Gene

glutathione S-transferase omega 1

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