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Aliases for GSTM5 Gene

Aliases for GSTM5 Gene

  • Glutathione S-Transferase Mu 5 2 3 5
  • Glutathione S-Transferase M5 2 3
  • GST Class-Mu 5 3 4
  • EC 2.5.1.18 4 63
  • GSTM5-5 3 4
  • S-(Hydroxyalkyl)Glutathione Lyase M5 3
  • Glutathione S-Aralkyltransferase M5 3
  • Glutathione S-Alkyltransferase M5 3
  • Glutathione S-Aryltransferase M5 3
  • GTM5 3

External Ids for GSTM5 Gene

Previous GeneCards Identifiers for GSTM5 Gene

  • GC01P110733
  • GC01P109184
  • GC01P109356
  • GC01P109553
  • GC01P109966
  • GC01P110056
  • GC01P110255
  • GC01P108124
  • GC01P110256

Summaries for GSTM5 Gene

Entrez Gene Summary for GSTM5 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTM5 Gene

GSTM5 (Glutathione S-Transferase Mu 5) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTM3.

UniProtKB/Swiss-Prot for GSTM5 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTM5 Gene

Genomics for GSTM5 Gene

Regulatory Elements for GSTM5 Gene

Promoters for GSTM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSTM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTM5 Gene

Chromosome:
1
Start:
109,711,761 bp from pter
End:
109,775,428 bp from pter
Size:
63,668 bases
Orientation:
Plus strand

Genomic View for GSTM5 Gene

Genes around GSTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTM5 Gene

Proteins for GSTM5 Gene

  • Protein details for GSTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46439-GSTM5_HUMAN
    Recommended name:
    Glutathione S-transferase Mu 5
    Protein Accession:
    P46439
    Secondary Accessions:
    • A8K0V8
    • Q6PD78

    Protein attributes for GSTM5 Gene

    Size:
    218 amino acids
    Molecular mass:
    25675 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTM5 Gene

Proteomics data for GSTM5 Gene at MOPED

Post-translational modifications for GSTM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GSTM5 Gene

Gene Families for GSTM5 Gene

Suggested Antigen Peptide Sequences for GSTM5 Gene

Graphical View of Domain Structure for InterPro Entry

P46439

UniProtKB/Swiss-Prot:

GSTM5_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Mu family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Mu family.
genes like me logo Genes that share domains with GSTM5: view

Function for GSTM5 Gene

Molecular function for GSTM5 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 5,mu class
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Enzyme Numbers (IUBMB) for GSTM5 Gene

Gene Ontology (GO) - Molecular Function for GSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with GSTM5: view
genes like me logo Genes that share phenotypes with GSTM5: view

Animal Models for GSTM5 Gene

MGI Knock Outs for GSTM5:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTM5 Gene

Localization for GSTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTM5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTM5 Gene COMPARTMENTS Subcellular localization image for GSTM5 gene
Compartment Confidence
cytosol 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for GSTM5 Gene

Pathways & Interactions for GSTM5 Gene

genes like me logo Genes that share pathways with GSTM5: view

Pathways by source for GSTM5 Gene

Gene Ontology (GO) - Biological Process for GSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GSTM5: view

No data available for SIGNOR curated interactions for GSTM5 Gene

Drugs & Compounds for GSTM5 Gene

(3) Drugs for GSTM5 Gene - From: HMDB, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Busulfan Approved, Investigational Pharma 506
Trichloroethylene Pharma 5

(40) Additional Compounds for GSTM5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTM5: view

Transcripts for GSTM5 Gene

mRNA/cDNA for GSTM5 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSTM5 Gene

Glutathione S-transferase mu 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3: -

Relevant External Links for GSTM5 Gene

GeneLoc Exon Structure for
GSTM5
ECgene alternative splicing isoforms for
GSTM5

Expression for GSTM5 Gene

mRNA expression in normal human tissues for GSTM5 Gene

mRNA differential expression in normal tissues according to GTEx for GSTM5 Gene

This gene is overexpressed in Ovary (x6.5).

Protein differential expression in normal tissues from HIPED for GSTM5 Gene

This gene is overexpressed in Ovary (20.5), Skin (16.1), and Brain (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTM5 Gene



SOURCE GeneReport for Unigene cluster for GSTM5 Gene Hs.75652

genes like me logo Genes that share expression patterns with GSTM5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GSTM5 Gene

Orthologs for GSTM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTM5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gstm1 35
  • 80.73 (n)
  • 76.15 (a)
Gstm1 16
Gm4845 36
  • 74 (a)
ManyToMany
Gm6665 36
  • 78 (a)
ManyToMany
Gstm1 36
  • 76 (a)
ManyToMany
Gstm2 36
  • 81 (a)
ManyToMany
Gstm3 36
  • 75 (a)
ManyToMany
Gstm4 36
  • 79 (a)
ManyToMany
Gstm6 36
  • 74 (a)
ManyToMany
Gstm7 36
  • 81 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia GSTM5 35
  • 98.93 (n)
  • 98.62 (a)
GSTM5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gstm1 35
  • 81.65 (n)
  • 77.52 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
ManyToMany
GSTM1 36
  • 79 (a)
ManyToMany
GSTM1 36
  • 83 (a)
ManyToMany
GSTM2 36
  • 81 (a)
ManyToMany
GSTM4 36
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstm 36
  • 63 (a)
ManyToMany
gstm3 36
  • 61 (a)
ManyToMany
zgc:173994 36
  • 63 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 36
  • 30 (a)
ManyToMany
gst-23 36
  • 29 (a)
ManyToMany
gst-25 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for GSTM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTM5 Gene

ENSEMBL:
Gene Tree for GSTM5 (if available)
TreeFam:
Gene Tree for GSTM5 (if available)

Paralogs for GSTM5 Gene

Paralogs for GSTM5 Gene

(6) SIMAP similar genes for GSTM5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GSTM5 Gene

genes like me logo Genes that share paralogs with GSTM5: view

Variants for GSTM5 Gene

Sequence variations from dbSNP and Humsavar for GSTM5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2227963 - 109,715,209(+) CTTCC(C/T)AAAYT reference, missense
rs17854972 - 109,713,505(+) ATGGG(A/G)CTCAC intron-variant, reference, missense
rs11807 -- 109,718,120(-) GAACC(A/G)TGCCA downstream-variant-500B, utr-variant-3-prime
rs366272 -- 109,709,956(-) GTGAA(C/T)TCTCA upstream-variant-2KB
rs366349 -- 109,709,888(-) AGGAA(A/T)CATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GSTM5 Gene

Variant ID Type Subtype PubMed ID
esv25172 CNV Gain+Loss 19812545
nsv872143 CNV Loss 21882294
esv1003982 CNV Deletion 20482838
nsv2310 CNV Loss 18451855
nsv10617 CNV Gain 18304495
dgv329n71 CNV Gain 21882294
nsv2332 CNV Insertion 18451855

Variation tolerance for GSTM5 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTM5 Gene

HapMap Linkage Disequilibrium report
GSTM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM5 Gene

Disorders for GSTM5 Gene

Relevant External Links for GSTM5

Genetic Association Database (GAD)
GSTM5
Human Genome Epidemiology (HuGE) Navigator
GSTM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTM5

No disorders were found for GSTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTM5 Gene

Publications for GSTM5 Gene

  1. A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5. (PMID: 8473333) Takahashi Y. … Listowsky I. (J. Biol. Chem. 1993) 2 3 4 67
  2. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. (PMID: 11684093) Rao A.V. … Shaha C. (FEBS Lett. 2001) 3 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. (PMID: 11173863) Schnakenberg E. … Schloot W. (Cytogenet. Cell Genet. 2000) 25 26

Products for GSTM5 Gene

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