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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTM4 Gene

protein-coding GIFtS: 69
GCID: GC01P110198

glutathione S-transferase mu 4

(Previous name: glutathione S-transferase M4 )

Explore 15 diseases affiliated with
GSTM4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glutathione S-Transferase Mu 4¹ ²		GTM4²
Glutathione S-Transferase M4¹ ²		GTS-Mu2²
GST-Mu2² ³		Glutathione S-Alkyltransferase M4²
GSTM4-4² ³		Glutathione S-Aralkyltransferase M4²
GST Class-Mu 4² ³		Glutathione S-Aryltransferase M4²
EC 2.5.1.18³ ⁸		S-(Hydroxyalkyl)Glutathione Lyase M4²

External Ids:	HGNC: 4636¹	Entrez Gene: 2948²	Ensembl: ENSG00000168765⁷	OMIM: 138333⁵	UniProtKB: Q03013³

ORGUL members:
	NONCODE:n407040

Export aliases for GSTM4 gene to outside databases

Previous GC identifers: GC01P110677 GC01P109128 GC01P109300 GC01P109497 GC01P109910 GC01P110000 GC01P108086

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTM4:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At

present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified:

alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the

mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens,

therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes

encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly

polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as

affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding

substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign

compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Active on 1-chloro-2,4-dinitrobenzene

summary for GSTM4:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTM4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTM4 gene promoter:
NF-kappaB HNF-3beta Meis-1b YY1 FOXO4 NF-kappaB2 Meis-1a NF-kappaB1 LyF-1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTM4 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3

GSTM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P110198: view genomic region (about GC identifiers)

Start:	110,198,698 bp from pter	End:	110,208,123 bp from pter
Size:	9,426 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013 (See protein sequence)

Recommended Name: Glutathione S-transferase Mu 4

Size: 218 amino acids; 25561 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for GSTM4:

4GTU (3D)

Secondary accessions: A8K765 Q05465 Q32NC1 Q6FH87

Alternative splicing: 2 isoforms: Q03013-1 Q03013-2

Explore the universe of human proteins at neXtProt for GSTM4: NX_Q03013

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q03013

4/16 DME Specific Peptides for GSTM4 (Q03013) (see all 16)

VDFLAYD

WLNEKFK

CGETEEE

CYSPDFE

GSTM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000841.1 NP_671489.1

ENSEMBL proteins:

ENSP00000358851 ENSP00000316471 ENSP00000358848 ENSP00000336744

Reactome Protein details: Q03013
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	ProSpec Recombinant Protein for GSTM4
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	8373352
GO:0005789	endoplasmic reticulum membrane	TAS	--

GSTM4 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTM4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012336 Thioredoxin-like_fold

IPR003081 GST_mu

IPR004046 GST_C

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR004045 Glutathione_S-Trfase_N

Graphical View of Domain Structure for InterPro Entry Q03013

ProtoNet protein and cluster: Q03013

2 Blocks protein families:

IPB003081 Mu-class glutathione S-transferase signature

IPB004045 Glutathione S-transferase

UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013

Similarity: Belongs to the GST superfamily. Mu family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Active on 1-chloro-2,4-dinitrobenzene

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Genatlas biochemistry entry for GSTM4:

glutathione-S-transferase 4,mu class

Enzyme Number (IUBMB): EC 2.5.1.18¹ ²

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		hsa-miR-4268
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IDA	8373352
GO:0019899	enzyme binding	IPI	8373352
GO:0042803	protein homodimerization activity	IPI	8373352
GO:0043295	glutathione binding	IDA	8373352

GSTM4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for GSTM4:

Decreased Wnt reporter activit

Decreased influenza A/WSN/33 r

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

Glutathione metabolism	1.00	glutathione-mediated detoxification I	0.53
Glutathione metabolism	0.92	Glutathione conjugation	0.50
Glutathione metabolism	0.70

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GSTM4

Glutathione metabolism

1 GeneGo (Thomson Reuters) Pathway for GSTM4

Glutathione metabolism

2 BioSystems Pathways for GSTM4

	glutathione-mediated detoxification I
	metapathway biotransformation

4 Reactome Pathways for GSTM4

	Metabolism
	Biological oxidations
	Glutathione conjugation
	Phase II conjugation

3 Kegg Pathways (Kegg details for GSTM4):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

GSTM4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GSTM4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/72 Interacting proteins for GSTM4 (Q03013^{2, 3} ENSP00000358851⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 72)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637²^,³, ENSP00000269305⁴	MINT-64041 I2D: score=5 STRING: ENSP00000269305
APLP1	P51693²^,³	MINT-64042 I2D: score=5
MED31	Q9Y3C7²^,³	MINT-64048 I2D: score=5
NELFCD	Q8IXH7²^,³	MINT-64856 I2D: score=5
UNC119	Q13432²^,³	MINT-64044 I2D: score=5

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006749	glutathione metabolic process	IDA	8373352
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0018916	nitrobenzene metabolic process	--	--
GO:0042178	xenobiotic catabolic process	IDA	8373352
GO:0044281	small molecule metabolic process	TAS	--

GSTM4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSTM4 for compounds About GeneDecksing

EMD Millipore small molecules for GSTM4:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTM4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

10/12 HMDB Compounds for GSTM4 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

6 DrugBank Compounds for GSTM4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	15796179 7974294 17139284 17016423 10905636 10592235
1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane	--	--	target	--	17139284 17016423 10592235
Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine	--	--	target	--	17139284 17016423 10592235
Glutathione Sulfonic Acid	--	--	target	--	17139284 17016423 10592235
S-Hexylglutathione	--	--	target	--	17139284 17016423 10592235
S-Octylglutathione	--	--	target	--	17139284 17016423 10592235

1 Novoseek chemical compound relationship for GSTM4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	66.4	1	8349586 (1)

Search CenterWatch for drugs/clinical trials and news about GSTM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTM4 gene (3 alternative transcripts):

NM_000850.4 NM_147148.2 NM_147149.1

Unigene Cluster for GSTM4:

Glutathione S-transferase mu 4

Hs.348387 [show with all ESTs]

Unigene Representative Sequence: NM_000850

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369836(uc001dyf.3 uc001dyg.3 uc009wfj.3) ENST00000464733

ENST00000461767 ENST00000479578 ENST00000326729(uc001dyh.2) ENST00000495742

ENST00000369833(uc009wfi.2) ENST00000489066 ENST00000485640 ENST00000478397

ENST00000493171 ENST00000493395 ENST00000336075

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTM4

Additional cDNA sequence:

AK291880.1 AK311000.1 BC015513.1 BC108729.1 CR541869.1 DQ062813.1 M96234.1 M99422.1

NR_024538.1

16 DOTS entries:

DT.95333290 DT.87078092 DT.100805853 DT.100773257 DT.100805856 DT.121350178 DT.92457647 DT.100805854

DT.121350220 DT.85104822 DT.95264467 DT.97799934 DT.97825710 DT.121350192 DT.121350195 DT.121350248

22 AceView cDNA sequences:

BI712945 NM_000850 BQ014829 BI768076 CR613309 AA360507 NM_147149 BM545679

BM708241 AI985029 F18406 BI912520 BQ691458 BM979928 CR621776 CK820609

NM_147148 AA360622 AA922461 BI791533 BU731330 CK820610

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCTGCCT

About this image
See GSTM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTM4

SOURCE GeneReport for Unigene cluster: Hs.348387

UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013

Tissue specificity: Expressed in a wide variety of tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including GSTM4:

Drug Metabolism: Phase II Enzymes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GSTM4 gene from 2/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	71(a) 70(a) (see all 3)	possible ortholog possible ortholog (see all 3)	4(105963341-105964741) 4(105944541-105950815)
zebrafish (Danio rerio)	Actinopterygii	gstm3⁶ gstm⁶ (see all 3)	glutathione S-transferase M (see all 3)	66(a) 63(a) (see all 3)	many ↔ many many ↔ many (see all 3)	8(26155115-26159957) 8(26148103-26150871)

ENSEMBL Gene Tree for GSTM4 (if available)
TreeFam Gene Tree for GSTM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSTM4 gene

GSTA4² GSTA5² GSTA3² GSTA1² GSTM1² GSTM3² GSTA2² GSTP1²

HPGDS² GSTM5² GSTM2²

6 SIMAP similar genes for GSTM4 using alignment to 3 protein entries: GSTM4_HUMAN (see all proteins):

GSTmu3 GSTM1 GSTM5 GSTM2 GSTM3 GSTP1

GSTM4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199569862^1,2		--	110196704(+)	`AAAGA-/AAGAAAGA`	3	--	us2k¹		0	--	--	--	--
rs200565920^1,2		--	110196716(+)	`AAAGA-/AAAG AAAGA`	3	--	us2k¹		0	--	--	--	--
rs9725364^1,2	C,A	--	110196719(+)	`GAAAAA/GAAAGA`	3	--	us2k¹ trp³		0	--	--	--	--
rs67613257^1,2	C,	--	110196760(+)	`AGAAA-/AGAAAG`	3	--	us2k¹		0	--	--	--	--
rs112002203^1,2	C	--	110196775(+)	`AAGAAA/GGAAAG`	3	--	us2k¹		0	--	--	--	--
rs182017203^1,2		--	110196809(+)	`GAAAGA/GAAGGA`	3	--	us2k¹		0	--	--	--	--
rs72328450^1,2	C,	--	110196812(+)	`GAAAG-/GAAAGA`	3	--	us2k¹		0	--	--	--	--
rs186511070^1,2		--	110196813(+)	`GAAAGA/GAAAGA`	3	--	us2k¹		0	--	--	--	--
rs189683285^1,2		--	110196838(+)	`AGAAAA/GGAAAG`	3	--	us2k¹		0	--	--	--	--
rs859222^1,2		--	110196839(-)	`tctttC/Tctttc`	3	--	us2k¹ trp³		1		NA	2

HapMap Linkage Disequilibrium report for GSTM4 (110198698 - 110208123 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GSTM4
5 CNVs: 84464 64585 74641 34678 84467
Human Gene Mutation Database (HGMD): GSTM4

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GSTM4 for disorders           About GeneDecksing

OMIM gene information: 138333    OMIM disorders: --

15 diseases for GSTM4:    About MalaCards

tinea pedis breast cancer susceptibility coronary heart disease hearing loss

breast cancer rheumatoid arthritis emphysema hepatitis b

arthritis ovarian cancer lung cancer atherosclerosis

hepatitis sarcoma hypertension

1 disease from the University of Copenhagen DISEASES database for GSTM4:

Tinea pedis

2 Novoseek disease relationships for GSTM4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer lung	23.8	2	12140136 (2)
cancer	0	1	12140136 (1)

Genetic Association Database (GAD): GSTM4
Human Genome Epidemiology (HuGE) Navigator: GSTM4 (20 documents)

Export disorders for GSTM4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GSTM4 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with GSTM4)

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Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4. (PubMed id 8349586)^{1, 2, 9} Comstock K.E.... Henner W.D. (1993)
Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. (PubMed id 8471052)^{1, 2, 9} Zhong S.... Wolf C.R. (1993)
A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer. (PubMed id 12140136)^{1, 4, 9} Liloglou T....Field J.K. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Linkage and association analysis of candidate genes in rheumatoid arthritis. (PubMed id 11508575)^{1, 4} John S....Worthington J. (2001)
Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain. (PubMed id 10905636)^{1, 7} Beuckmann C.T....Hayaishi O. (2000)
An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S- transferases. (PubMed id 10587441)^{1, 2} Patskovsky Y.V.... Listowsky I. (1999)
A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes. (PubMed id 8203914)^{1, 2} Comstock K.E.... Mannervik B. (1994)
Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. (PubMed id 8373352)^{1, 2} Ross V.L. and Board P.G. (1993)
Chromosomal mapping of the human Mu class glutathione S-transferases to 1p13. (PubMed id 8276420)^{1, 3} Ross V.L....Webb G.C. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2948	HGNC: 4636	AceView: GSTM4	Ensembl:ENSG00000168765	euGenes: HUgn2948
ECgene: GSTM4	Kegg: 2948	H-InvDB: GSTM4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GSTM4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GSTM4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GSTM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GSTM4 gene:
Search GeneIP for patents involving GSTM4

GeneCards and IP:
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glutathione S-transferase mu 4

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glutathione S-transferase mu 4

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