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GSTM4 Gene

protein-coding   GIFtS: 69
GCID: GC01P110198

Glutathione S-Transferase Mu 4

(Previous name: glutathione S-transferase M4)
  See GSTM4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Mu 41 2     GTM42
Glutathione S-Transferase M41 2     GTS-Mu22
GST-Mu22 3     Glutathione S-Alkyltransferase M42
GSTM4-42 3     Glutathione S-Aralkyltransferase M42
GST Class-Mu 42 3     Glutathione S-Aryltransferase M42
EC 2.5.1.183 8     S-(Hydroxyalkyl)Glutathione Lyase M42

External Ids:    HGNC: 46361   Entrez Gene: 29482   Ensembl: ENSG000001687657   OMIM: 1383335   UniProtKB: Q030133   

Export aliases for GSTM4 gene to outside databases

Previous GC identifers: GC01P110677 GC01P109128 GC01P109300 GC01P109497 GC01P109910 GC01P110000 GC01P108086


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTM4 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At
present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been
identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase
that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds,
including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation
with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3
and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to
carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these
genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to
accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct
protein isoform, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTM4 Gene:
GSTM4 (glutathione S-transferase mu 4) is a protein-coding gene. Diseases associated with GSTM4 include tinea pedis, and breast cancer susceptibility. GO annotations related to this gene include glutathione transferase activity and protein homodimerization activity. An important paralog of this gene is GSTP1.

UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Active on 1-chloro-2,4-dinitrobenzene

Gene Wiki entry for GSTM4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTM4 gene promoter:
         NF-kappaB   HNF-3beta   Meis-1b   YY1   FOXO4   NF-kappaB2   Meis-1a   NF-kappaB1   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTM4 promoter sequence
   Search Chromatin IP Primers for GSTM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

GSTM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110198:  view genomic region     (about GC identifiers)

Start:
110,198,698 bp from pter      End:
110,208,123 bp from pter
Size:
9,426 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for GSTM4

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013 (See protein sequence)
Recommended Name: Glutathione S-transferase Mu 4  
Size: 218 amino acids; 25561 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for GSTM4:
4GTU (3D)    
Secondary accessions: A8K765 Q05465 Q32NC1 Q4JNT8 Q6FH87
Alternative splicing: 3 isoforms:  Q03013-1   Q03013-2   Q03013-3   

Explore the universe of human proteins at neXtProt for GSTM4: NX_Q03013

Explore proteomics data for GSTM4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys52
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTM4 (Q03013) (see all 16)
     VDFLAYD  WLNEKFK  CGETEEE  CYSPDFE 


    See GSTM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000841.1  NP_671489.1  

    ENSEMBL proteins: 
     ENSP00000358851   ENSP00000316471   ENSP00000358848   ENSP00000336744  
    Reactome Protein details: Q03013

    GSTM4 Human Recombinant Protein Products:

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    Novus Biologicals GSTM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTM4
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GSTM4 

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    Search eBioscience for ELISAs for GSTM4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003081 GST_mu
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q03013

    ProtoNet protein and cluster: Q03013

    2 Blocks protein domains:
    IPB003081 Mu-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013
    Similarity: Belongs to the GST superfamily. Mu family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTM4_HUMAN, Q03013
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Active on 1-chloro-2,4-dinitrobenzene
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTM4:
    glutathione-S-transferase 4,mu class

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA8373352
    GO:0005515protein binding ----
    GO:0019899enzyme binding IPI8373352
    GO:0042803protein homodimerization activity IPI8373352
    GO:0043295glutathione binding IDA8373352
         
    Find genes that share ontologies with GSTM4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GSTM4:
     Decreased Wnt reporter activit  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTM4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTM4
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    miRNA
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    miRTarBase miRNAs that target GSTM4:
    hsa-mir-16-5p (MIRT001461)

    Block miRNA regulation of human, mouse, rat GSTM4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GSTM4:
    hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidGSTM4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GSTM4

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    GenScript: all cDNA clones in your preferred vector (see all 2): GSTM4 (NM_147148)
    Sino Biological Human cDNA Clone for GSTM4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTM4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTM4_HUMAN, Q03013: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA8373352
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GSTM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTM4 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with GSTM4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GSTM4
        Glutathione metabolism

    2 BioSystems Pathways for GSTM4
        glutathione-mediated detoxification I
    metapathway biotransformation


    1 Reactome Pathway for GSTM4
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for GSTM4):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTM4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GSTM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTM4 (Q030132, 3 ENSP000003588514) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-64041 I2D: score=5 STRING: ENSP00000269305
    APLP1P516932, 3MINT-64042 I2D: score=5 
    MED31Q9Y3C72, 3MINT-64048 I2D: score=5 
    NELFCDQ8IXH72, 3MINT-64856 I2D: score=5 
    UNC119Q134322, 3MINT-64044 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA8373352
    GO:0006805xenobiotic metabolic process TAS--
    GO:0042178xenobiotic catabolic process IDA8373352
    GO:0044281small molecule metabolic process TAS--
    GO:1901687glutathione derivative biosynthetic process TAS--

    Find genes that share ontologies with GSTM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTM4

    Selected HMDB Compounds for GSTM4 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    6 DrugBank Compounds for GSTM4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--15796179 7974294 17139284 17016423 10905636 10592235
    1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane-- --target--17139284 17016423 10592235
    Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine-- --target--17139284 17016423 10592235
    Glutathione Sulfonic Acid-- --target--17139284 17016423 10592235
    S-Hexylglutathione-- --target--17139284 17016423 10592235
    S-Octylglutathione-- --target--17139284 17016423 10592235

    1 Novoseek inferred chemical compound relationship for GSTM4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 66.4 1 8349586 (1)



    Find genes that share compounds with GSTM4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GSTM4 gene (3 alternative transcripts): 
    NM_000850.4  NM_147148.2  NM_147149.1  

    Unigene Cluster for GSTM4:

    Glutathione S-transferase mu 4
    Hs.348387  [show with all ESTs]
    Unigene Representative Sequence: NM_000850
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369836(uc001dyf.3 uc001dyg.3 uc009wfj.3) ENST00000464733
    ENST00000461767 ENST00000479578 ENST00000326729(uc001dyh.2) ENST00000495742
    ENST00000369833(uc009wfi.2) ENST00000485640 ENST00000478397 ENST00000493171
    ENST00000493395 ENST00000336075
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    1 qRT-PCR Assays for microRNA that regulate GSTM4:
    hsa-miR-4268
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GSTM4
      QuantiFast Probe-based Assays in human, mouse, rat GSTM4

    Additional mRNA sequence: 

    AK291880.1 AK311000.1 BC015513.1 BC108729.1 CR541869.1 DQ062813.1 M96234.1 M99422.1 
    NR_024538.1 

    16 DOTS entries:

    DT.95333290  DT.87078092  DT.100805853  DT.100773257  DT.100805856  DT.121350178  DT.92457647  DT.100805854 
    DT.121350220  DT.85104822  DT.95264467  DT.97799934  DT.97825710  DT.121350192  DT.121350195  DT.121350248 

    22 AceView cDNA sequences:

    BI768076 NM_147148 AA360622 CR621776 BM545679 BI712945 F18406 BQ014829 
    AA360507 NM_000850 NM_147149 BM708241 BM979928 AA922461 AI985029 CR613309 
    BI912520 CK820609 BQ691458 BU731330 BI791533 CK820610 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTGCCT
    GSTM4 Expression
    About this image


    GSTM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GSTM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348387

    UniProtKB/Swiss-Prot: GSTM4_HUMAN, Q03013
    Tissue specificity: Expressed in a wide variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTM4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat GSTM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTM4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstm41 , 5 glutathione S-transferase, mu 41, 5 85.47(n)1
    87.16(a)1
      3 (46.83 cM)5
    148651  NM_026764.31  NP_081040.11 
     1080404085 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    71(a)
    70(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(105963341-105964741)
    4(105944541-105950815)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739946
    gstm6
    (see all 3)
    glutathione S-transferase M
    (see all 3)
    65(a)
    64(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    8(26152012-26154745) ENSDARG00000029473
    8(26148103-26150871) ENSDARG00000042533
    worm
    (Caenorhabditis elegans)
    Secernentea gst-16
    gst-236
    (see all 3)
    Protein GST-23 (gst-23) mRNA, complete cds
    (see all 3)
    30(a)
    30(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9058904-9060183) WBGene00001749
    V(3243295-3244494) WBGene00001771


    ENSEMBL Gene Tree for GSTM4 (if available)
    TreeFam Gene Tree for GSTM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTM4 gene
    GSTP12  GSTM12  GSTM32  GSTM52  GSTM22  
    6 SIMAP similar genes for GSTM4 using alignment to 2 protein entries:     GSTM4_HUMAN (see all proteins):
    GSTM5    GSTmu3    GSTM1    GSTM2    GSTM3    GSTP1

    Find genes that share paralogs with GSTM4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTM4 (see all 381)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995698621,2
    --110196704(+) AAAGA-/AAGAAAGA 3 -- us2k10--------
    rs719945551,2
    C--110196715(+) GAAAG-/AAAAGA 3 -- us2k10--------
    rs2005659201,2
    --110196716(+) AAAGA-/AAAG  
            
    AAAGA
    3 -- us2k10--------
    rs97300131,2
    A--110196718(+) agaaaA/Ggaaag 3 -- us2k1 trp30--------
    rs97253641,2
    C,A--110196719(+) GAAAAA/GAAAGA 3 -- us2k1 trp30--------
    rs676132571,2
    C--110196760(+) AGAAA-/AGAAAG 3 -- us2k10--------
    rs1120022031,2
    C--110196775(+) AAGAAA/GGAAAG 3 -- us2k10--------
    rs1820172031,2
    --110196809(+) GAAAGA/GAAGGA 3 -- us2k10--------
    rs723284501,2
    C--110196812(+) GAAAG-/GAAAGA 3 -- us2k10--------
    rs1865110701,2
    --110196813(+) GAAAGA/GAAAGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GSTM4 (110198698 - 110208123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GSTM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872142CNV Loss21882294
    nsv2299CNV Loss18451855
    esv25172CNV Gain+Loss19812545
    nsv510951CNV Complex20534489

    Human Gene Mutation Database (HGMD): GSTM4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTM4
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138333    OMIM disorders: --

    2 diseases for GSTM4:    
    About MalaCards
    tinea pedis    breast cancer susceptibility

    1 disease from the University of Copenhagen DISEASES database for GSTM4:
    Tinea pedis

    Find genes that share disorders with GSTM4           About GenesLikeMe

    2 Novoseek inferred disease relationships for GSTM4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 23.8 2 12140136 (2)
    cancer 0 1 12140136 (1)

    Genetic Association Database (GAD): GSTM4
    Human Genome Epidemiology (HuGE) Navigator: GSTM4 (20 documents)

    Export disorders for GSTM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTM4 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with GSTM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4. (PubMed id 8349586)1, 2, 9 Comstock K.E.... Henner W.D. (J. Biol. Chem. 1993)
    2. Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. (PubMed id 8471052)1, 2, 9 Zhong S.... Wolf C.R. (Biochem. J. 1993)
    3. A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer. (PubMed id 12140136)1, 4, 9 Liloglou T....Field J.K. (Lung Cancer 2002)
    4. Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons. (PubMed id 16854533)1, 2, 9 Denson J.... Zhang J. (Gene 2006)
    5. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    6. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (amp 2010)
    7. Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. (PubMed id 19856098)1, 4 Yu K.D....Shao Z.M. (Breast Cancer Res. Treat. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    10. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2948 HGNC: 4636 AceView: GSTM4 Ensembl:ENSG00000168765 euGenes: HUgn2948
    ECgene: GSTM4 Kegg: 2948 H-InvDB: GSTM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GSTM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTM4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GSTM4 gene:
    Search GeneIP for patents involving GSTM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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