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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTM3 Gene

protein-coding GIFtS: 67
GCID: GC01M110276

glutathione S-transferase mu 3 (brain)

(Previous name: glutathione S-transferase M3 (brain) )

Explore 67 diseases affiliated with
GSTM3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glutathione S-Transferase Mu 3 (Brain)¹ ²		Brain GST²
GST5¹ ² ³ ⁵		Brain Type Mu-Glutathione S-Transferase²
Glutathione S-Transferase M3 (Brain)¹ ²		Glutathione S-Alkyltransferase M3²
GSTM3-3² ³		Glutathione S-Aralkyltransferase M3²
GST Class-Mu 3² ³		Glutathione S-Aryltransferase M3²
HGSTM3-3¹		Glutathione S-Transferase Mu 3²
EC 2.5.1.18³ ⁸		Glutathione S-Transferase, Mu-3²
GSTB²		S-(Hydroxyalkyl)Glutathione Lyase M3²
GTM3²

External Ids:	HGNC: 4635¹	Entrez Gene: 2947²	Ensembl: ENSG00000134202⁷	OMIM: 138390⁵	UniProtKB: P21266³

ORGUL members:
	NONCODE:n407039

Export aliases for GSTM3 gene to outside databases

Previous GC identifers: GC01M110758 GC01M109208 GC01M109381 GC01M109577 GC01M109576 GC01M109988 GC01M108146

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTM3:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At

present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified:

alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the

mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens,

therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes

encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly

polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as

affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight

increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in

multiple transcript variants. (provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood

barriers

summary for GSTM3:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTM3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTM3 gene promoter:
LUN-1 STAT5A NF-kappaB NF-AT AREB6 NF-AT4 NF-AT2 NF-AT3 NF-kappaB1 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTM3 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTM3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTM3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3

GSTM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M110276: view genomic region (about GC identifiers)

Start:	110,276,554 bp from pter	End:	110,284,384 bp from pter
Size:	7,831 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266 (See protein sequence)

Recommended Name: Glutathione S-transferase Mu 3

Size: 225 amino acids; 26560 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for GSTM3:

3GTU (3D)

Secondary accessions: O60550 Q96HA3

Explore the universe of human proteins at neXtProt for GSTM3: NX_P21266

Post-translational modifications:

The N-terminus is blocked¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21266

4/8 DME Specific Peptides for GSTM3 (P21266) (see all 8)

CGETEEE

RFEALEKI

LGYWDIRG

KITQSNAI

GSTM3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000840.2

ENSEMBL proteins:

ENSP00000354357 ENSP00000444978 ENSP00000256594

Human Recombinant Protein Products for GSTM3:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IDA	8373352

GSTM3 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTM3 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012336 Thioredoxin-like_fold

IPR003081 GST_mu

IPR004046 GST_C

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR004045 Glutathione_S-Trfase_N

Graphical View of Domain Structure for InterPro Entry P21266

ProtoNet protein and cluster: P21266

2 Blocks protein families:

IPB003081 Mu-class glutathione S-transferase signature

IPB004045 Glutathione S-transferase

UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266

Similarity: Belongs to the GST superfamily. Mu family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GSTM3_HUMAN, P21266

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood

barriers

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Biophysicochemical properties: Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene; KM=0.084 mM for

glutathione;

Genatlas biochemistry entry for GSTM3:

glutathione-S-transferase 3,mu class,expressed in brain

Enzyme Number (IUBMB): EC 2.5.1.18¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IDA	8373352
GO:0019899	enzyme binding	IPI	8373352
GO:0042802	identical protein binding	IPI	19060904
GO:0042803	protein homodimerization activity	IPI	8373352
GO:0043295	glutathione binding	IDA	8373352

GSTM3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GSTM3:

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GSTM3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

	Glutathione metabolism	1.00			Glutathione metabolism	0.70
	Glutathione metabolism	0.92			glutathione-mediated detoxification I	0.53

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Diurnally regulated genes with circadian orthologs

Diurnally regulated genes with circadian orthologs

1.00

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GSTM3

Glutathione metabolism

1 GeneGo (Thomson Reuters) Pathway for GSTM3

Glutathione metabolism

3 BioSystems Pathways for GSTM3

	Diurnally regulated genes with circadian orthologs
	glutathione-mediated detoxification I
	metapathway biotransformation

3 Kegg Pathways (Kegg details for GSTM3):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

GSTM3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GSTM3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/81 Interacting proteins for GSTM3 (P21266^{1, 2, 3} ENSP00000256594⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 81)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000206435	P30504³	I2D: score=1
ENSG00000206452	P30504³	I2D: score=1
HLA-C	P30504³	I2D: score=1
SH3GL2	Q99962²^,³, ENSP00000369981⁴	MINT-8270473 I2D: score=2 STRING: ENSP00000369981
GSTM2	P28161³, ENSP00000241337⁴	I2D: score=2 STRING: ENSP00000241337

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006749	glutathione metabolic process	IDA	8373352
GO:0008065	establishment of blood-nerve barrier	TAS	2345169
GO:0018916	nitrobenzene metabolic process	IDA	8373352
GO:0042178	xenobiotic catabolic process	IDA	8373352
GO:0043627	response to estrogen stimulus	IEP	10037815

GSTM3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSTM3 for compounds About GeneDecksing

EMD Millipore small molecules for GSTM3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTM3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

10/12 HMDB Compounds for GSTM3 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

2 DrugBank Compounds for GSTM3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17372252 17617661
Vitamin E	alpha-Tocopherol (see all 2)	59-02-9	enzyme	inducer	18789671

3 Novoseek chemical compound relationships for GSTM3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	84.4	1	10762000 (1)
epoxide	46.2	3	12359356 (1), 11289100 (1), 7728947 (1)
oxygen	0	2	17904251 (1)

2 PharmGKB related drug/compound annotations for GSTM3 gene About this table

Drug/compound	PharmGKB Annotation
cisplatin	CA
cyclophosphamide	CA

Search CenterWatch for drugs/clinical trials and news about GSTM3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTM3 gene:

NM_000849.4

Unigene Cluster for GSTM3:

Glutathione S-transferase mu 3 (brain)

Hs.2006 [show with all ESTs]

Unigene Representative Sequence: NM_000849

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361066(uc010ovv.2) ENST00000486823 ENST00000476321 ENST00000488824

ENST00000540225 ENST00000256594(uc001dyo.2 uc001dyp.2)

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Additional cDNA sequence:

AB209816.1 AK131000.1 AK304300.1 AK313444.1 BC000088.2 BC008790.2 BC030253.1 BT019945.1

CR542108.1 EF363096.1 J05459.1 NR_024537.1

14 DOTS entries:

DT.100872731 DT.40204031 DT.100659828 DT.100018411 DT.100659830 DT.95110038 DT.100659827 DT.95110012

DT.100641595 DT.121350243 DT.95256490 DT.423766 DT.95110034 DT.121350248

24/389 AceView cDNA sequences (see all 389):

AL134603 BM718047 BU663191 BM680499 AL558547 AA916843 AU102310 CB988848

AA812886 BU661542 BQ187085 BQ051402 BI826380 BE551668 AU100353 BU657565

CR591709 BF754379 AI954800 BF446372 CA444763 BQ003975 BM997216 CF126127

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GSTM3 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b
SP1:							-
SP2:							-		-
SP3:
SP4:

ECgene alternative splicing isoforms for GSTM3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCGTTTTG

About this image

GSTM3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GSTM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTM3

SOURCE GeneReport for Unigene cluster: Hs.2006

UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266

Tissue specificity: Testis and brain

SABiosciences Expression via Pathway-Focused PCR Arrays including GSTM3:

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GSTM3 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gstm3⁵ Gstm5¹	glutathione S-transferase, mu 3⁵ glutathione S-transferase, mu 5¹	87.88(n)¹ 89.55(a)¹		3 (46.83 cM)⁵ 14866¹ NM_010360.2¹ NP_034490.1¹ 107942333⁵
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	69(a) 66(a) (see all 3)	possible ortholog possible ortholog (see all 3)	4(105980049-105989478) 4(105944541-105950815)
zebrafish (Danio rerio)	Actinopterygii	wufc26g06²	Danio rerio cDNA clone MGC66370 IMAGE5612162, complete more	74.66(n)		BC057526.1

ENSEMBL Gene Tree for GSTM3 (if available)
TreeFam Gene Tree for GSTM3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GSTM3 gene

GSTA4² GSTA5² GSTA3² GSTA1² GSTM1² GSTA2² GSTP1² GSTM4²

HPGDS² GSTM5² GSTM2²

6 SIMAP similar genes for GSTM3 using alignment to 3 protein entries: GSTM3_HUMAN (see all proteins):

GSTmu3 GSTM1 GSTM5 GSTM2 GSTM4 GSTP1

GSTM3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GSTM3
PGOHUM00000247610 PGOHUM00000240402

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191282535^1,2		--	110276163(+)	`GGTGGC/TCGTGT`	2	--	ds500¹		0	--	--	--	--
rs151038838^1,2		--	110276231(+)	`ATGGAG/TGGCCT`	2	--	ds500¹		0	--	--	--	--
rs56084361^1,2	C,F	--	110276263(-)	`ATAGCG/ATCAGT`	2	--	ds500¹		6		NS NA	300
rs139672534^1,2		--	110276275(+)	`AACAAC/TTACAC`	2	--	ds500¹		0	--	--	--	--
rs143503320^1,2		--	110276340(+)	`GGATGA/TCACAC`	2	--	ds500¹		0	--	--	--	--
rs183732820^1,2		--	110276548(+)	`ACATGA/GACATG`	2	--	ds500¹		0	--	--	--	--
rs56328314^1,2	C,F	--	110276565(-)	`CTGCCC/TTACTC`	2	--	nc-transcript-variantut3¹		7		NS WA	308
rs186960043^1,2		--	110276573(+)	`CAGAGG/TAGAAT`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs56246262^1,2	C,F	--	110276772(-)	`AGATGG/CAGTCC`	2	--	nc-transcript-variantut3¹		7		NS WA	310
rs112564505^1,2		--	110276809(+)	`AAAACC/TCATGG`	2	--	ut3¹ nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for GSTM3 (110276554 - 110284384 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GSTM3: --
Human Gene Mutation Database (HGMD): GSTM3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GSTM3 for disorders           About GeneDecksing

OMIM gene information: 138390    OMIM disorders: --

20/67 diseases for GSTM3 (see all 67):    About MalaCards

open-angle glaucoma primary open angle glaucoma laryngeal squamous cell carcinoma malignant pleural mesothelioma

non-hodgkin lymphoma squamous cell carcinoma polycystic ovary syndrome laryngitis

oral leukoplakia leukoplakia glaucoma hodgkin's lymphoma

breast cancer susceptibility coronary heart disease bronchogenic carcinoma hearing loss

sporadic breast cancer basal cell carcinoma chronic lymphocytic leukemia breast cancer

10/18 Novoseek disease relationships for GSTM3 gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
laryngeal squamous cell carcinoma	55.6	1	19922706 (1)
pharyngeal cancer	53.9	3	10077151 (2), 10407823 (1)
carcinoma basal cell	45.1	2	8616834 (2)
oral cancer	42.3	10	12016153 (3), 10762000 (3), 14735473 (2)
laryngeal cancer	40.9	4	10067818 (2), 12359356 (1), 10407823 (1)
cancer	40.5	12	14735473 (3), 10022746 (2), 16760134 (1), 8616834 (1) (see all 8)
cancer lung	31.9	6	9918133 (3), 7614465 (1), 7728947 (1)
carcinoma squamous cell	25.5	2	12548461 (1), 10498401 (1)
neck cancer	22.7	1	10407823 (1)
breast cancer	17.5	3	19856098 (2), 12888106 (1)

Genetic Association Database (GAD): GSTM3
Human Genome Epidemiology (HuGE) Navigator: GSTM3 (116 documents)

Export disorders for GSTM3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GSTM3 gene, integrated from 9 sources (see all 185):
(articles sorted by number of sources associating them with GSTM3)

Utopia: connect your pdf to the dynamic
world of online information

A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. (PubMed id 2345169)^{1, 2, 3} Campbell E.... Listowsky I. (1990)
Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. (PubMed id 14735473)^{1, 4, 9} Sikdar N....Roy B. (2004)
Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms. (PubMed id 14968442)^{1, 4, 9} Medeiros R....Lopes C. (2004)
Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PubMed id 15338373)^{1, 4, 9} Schneider A....Whitcomb D.C. (2004)
An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PubMed id 17372252)^{1, 7, 9} Schwartzbaum J.A....Feychting M. (2007)
Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population. (PubMed id 12016153)^{1, 4, 9} Buch S.C....Bhisey R.A. (2002)
Glutathione-S-transferase M1, M3, P1 and T1 polymorphisms and severity of lung disease in children with cystic fibrosis. (PubMed id 15115915)^{1, 4, 9} Flamant C....Clement A. (2004)
Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. (PubMed id 11040079)^{1, 4, 9} Juronen E....Mikelsaar A.V. (2000)
Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor. (PubMed id 11408349)^{1, 4, 9} Loktionov A....Bingham S.A. (2001)
A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas. (PubMed id 11289100)^{1, 4, 9} Cortessis V....Levy D. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2947	HGNC: 4635	AceView: GSTM3	Ensembl:ENSG00000134202	euGenes: HUgn2947
ECgene: GSTM3	Kegg: 2947	H-InvDB: GSTM3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GSTM3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GSTM3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GSTM3 gene
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Patent Information for GSTM3 gene:
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glutathione S-transferase mu 3 (brain)

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glutathione S-transferase mu 3 (brain)

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