Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GSTM3 Gene

protein-coding   GIFtS: 70
GCID: GC01M110276

Glutathione S-Transferase Mu 3 (Brain)

(Previous name: glutathione S-transferase M3 (brain))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutathione S-Transferase Mu 3 (Brain)1 2     Brain GST2
GST52 3 5     Brain Type Mu-Glutathione S-Transferase2
Glutathione S-Transferase M3 (Brain)1 2     Glutathione S-Alkyltransferase M32
GSTM3-32 3     Glutathione S-Aralkyltransferase M32
GST Class-Mu 32 3     Glutathione S-Aryltransferase M32
hGSTM3-32 3     Glutathione S-Transferase Mu 32
EC 2.5.1.183 8     Glutathione S-Transferase, Mu-32
GSTB2     S-(Hydroxyalkyl)Glutathione Lyase M32
GTM32     

External Ids:    HGNC: 46351   Entrez Gene: 29472   Ensembl: ENSG000001342027   OMIM: 1383905   UniProtKB: P212663   

Export aliases for GSTM3 gene to outside databases

Previous GC identifers: GC01M110758 GC01M109208 GC01M109381 GC01M109577 GC01M109576 GC01M109988 GC01M108146


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GSTM3 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At
present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been
identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase
that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds,
including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation
with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3
and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to
carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu
gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental
toxins. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2008)

GeneCards Summary for GSTM3 Gene:
GSTM3 (glutathione S-transferase mu 3 (brain)) is a protein-coding gene. Diseases associated with GSTM3 include bronchogenic carcinoma, and oral cancer. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is GSTP1.

UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis
and brain blood barriers

Gene Wiki entry for GSTM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTM3 gene promoter:
         LUN-1   STAT5A   NF-kappaB   NF-AT   AREB6   NF-AT4   NF-AT2   NF-AT3   NF-kappaB1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTM3 promoter sequence
   Search Chromatin IP Primers for GSTM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

GSTM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M110276:  view genomic region     (about GC identifiers)

Start:
110,276,554 bp from pter      End:
110,284,384 bp from pter
Size:
7,831 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266 (See protein sequence)
Recommended Name: Glutathione S-transferase Mu 3  
Size: 225 amino acids; 26560 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for GSTM3:
3GTU (3D)    
Secondary accessions: O60550 Q96HA3

Explore the universe of human proteins at neXtProt for GSTM3: NX_P21266

Explore proteomics data for GSTM3 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Ubiquitination2 at Lys128
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTM3 (P21266) (see all 8)
     CGETEEE  RFEALEKI  LGYWDIRG  KITQSNAI 


    See GSTM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000840.2  
    ENSEMBL proteins: 
     ENSP00000354357   ENSP00000444978   ENSP00000256594  
    Reactome Protein details: P21266

    GSTM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GSTM3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GSTM3
    GenScript Custom Purified and Recombinant Proteins Services for GSTM3
    Novus Biologicals GSTM3 Proteins
    Novus Biologicals GSTM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTM3
    Browse Proteins at Cloud-Clone Corp.

    GSTM3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GSTM3
    Novus Biologicals GSTM3 Antibodies
    Abcam antibodies for GSTM3
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for GSTM3
    LSBio Antibodies in human, mouse, rat for GSTM3

    GSTM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GSTM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GSTM3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003081 GST_mu
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P21266

    ProtoNet protein and cluster: P21266

    2 Blocks protein domains:
    IPB003081 Mu-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266
    Similarity: Belongs to the GST superfamily. Mu family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTM3_HUMAN, P21266
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis
    and brain blood barriers
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Biophysicochemical properties: Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene; KM=0.084 mM for
    glutathione;

         Genatlas biochemistry entry for GSTM3:
    glutathione-S-transferase 3,mu class,expressed in brain

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA10587441
    GO:0005515protein binding ----
    GO:0019899enzyme binding IPI8373352
    GO:0042802identical protein binding IPI16189514
    GO:0042803protein homodimerization activity IPI8373352
         
    GSTM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTM3:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTM3

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSTM3:
    hsa-mir-122-5p (MIRT023377), hsa-mir-92b-3p (MIRT040526)

    Block miRNA regulation of human, mouse, rat GSTM3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate GSTM3:
    hsa-miR-3606 hsa-miR-1276 hsa-miR-4328 hsa-miR-1208 hsa-miR-921 hsa-miR-1976
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTM3
    Predesigned siRNA for gene silencing in human, mouse, rat GSTM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTM3

    Clone
    Products:
         
    OriGene clones in human, mouse for GSTM3 (see all 6)
    OriGene ORF clones in mouse, rat for GSTM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTM3 (NM_000849)
    Sino Biological Human cDNA Clone for GSTM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTM3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GSTM3
    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTM3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GSTM3_HUMAN, P21266: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA8373352
    GO:0005829cytosol TAS--

    GSTM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GSTM3 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GSTM3
        Glutathione metabolism

    3 BioSystems Pathways for GSTM3
        Diurnally regulated genes with circadian orthologs
    glutathione-mediated detoxification I
    metapathway biotransformation


    1 Reactome Pathway for GSTM3
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for GSTM3):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTM3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTM3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSTM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTM3 (P212661, 2, 3 ENSP000002565944) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    SH3GL2Q999622, 3, ENSP000003699814MINT-8270473 I2D: score=2 STRING: ENSP00000369981
    GSTM2P281613, ENSP000002413374I2D: score=2 STRING: ENSP00000241337
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA10587441
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008065establishment of blood-nerve barrier TAS2345169
    GO:0018916nitrobenzene metabolic process IDA8373352
    GO:0042178xenobiotic catabolic process IDA8373352

    GSTM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTM3

    Selected HMDB Compounds for GSTM3 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    2 DrugBank Compounds for GSTM3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17372252 17617661
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9enzymeinducer18789671

    3 Novoseek inferred chemical compound relationships for GSTM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 84.4 1 10762000 (1)
    epoxide 46.2 3 12359356 (1), 11289100 (1), 7728947 (1)
    oxygen 0 2 17904251 (1)

    2 PharmGKB related drug/compound annotations for GSTM3 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    cyclophosphamideCA  



    GSTM3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GSTM3 gene: 
    NM_000849.4  

    Unigene Cluster for GSTM3:

    Glutathione S-transferase mu 3 (brain)
    Hs.2006  [show with all ESTs]
    Unigene Representative Sequence: NM_000849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361066(uc010ovv.2) ENST00000486823 ENST00000476321 ENST00000488824
    ENST00000540225 ENST00000256594(uc001dyo.2 uc001dyp.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GSTM3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate GSTM3:
    hsa-miR-3606 hsa-miR-1276 hsa-miR-4328 hsa-miR-1208 hsa-miR-921 hsa-miR-1976
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSTM3
    Predesigned siRNA for gene silencing in human, mouse, rat GSTM3
    Clone
    Products:
         
    OriGene clones in human, mouse for GSTM3 (see all 6)
    OriGene ORF clones in mouse, rat for GSTM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTM3 (NM_000849)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTM3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GSTM3
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTM3
      QuantiTect SYBR Green Assays in human, mouse, rat GSTM3
      QuantiFast Probe-based Assays in human, mouse, rat GSTM3

    Additional mRNA sequence: 

    AB209816.1 AK131000.1 AK304300.1 AK313444.1 BC000088.2 BC008790.2 BC030253.1 BT019945.1 
    CR542108.1 EF363096.1 J05459.1 NR_024537.1 

    14 DOTS entries:

    DT.100872731  DT.40204031  DT.100659828  DT.100018411  DT.100659830  DT.95110038  DT.100659827  DT.95110012 
    DT.100641595  DT.121350243  DT.95256490  DT.423766  DT.95110034  DT.121350248 

    Selected AceView cDNA sequences (see all 389):

    BE551668 BM680499 BM708738 NM_000849 CA436176 BU660482 BI828512 BE551661 
    BQ722525 BF446372 CN485180 BQ051402 BX095360 BF754379 CA445005 AL553432 
    BM702995 BE395938 CA389092 CB988848 BM793887 AA812886 BM997216 BQ003975 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GSTM3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:                    -                                                         
    SP2:                    -     -                                                   
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for GSTM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GSTM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCGTTTTG
    GSTM3 Expression
    About this image


    GSTM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
     
     Gonad
             Primordial Germ Cells Primitive Gonad
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
    GSTM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2006

    UniProtKB/Swiss-Prot: GSTM3_HUMAN, P21266
    Tissue specificity: Testis and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTM3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSTM3
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTM3
    QuantiTect SYBR Green Assays in human, mouse, rat GSTM3
    QuantiFast Probe-based Assays in human, mouse, rat GSTM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GSTM3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstm35
    Gstm51
    glutathione S-transferase, mu 35
    glutathione S-transferase, mu 51
    87.88(n)1
    89.55(a)1
      3 (46.83 cM)5
    148661  NM_010360.21  NP_034490.11 
     1079423335 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    70(a)
    65(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(105979841-105989135)
    4(105944541-105950815)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc26g062 Danio rerio cDNA clone MGC66370 IMAGE5612162, complete more 74.66(n)    BC057526.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-16
    gst-236
    (see all 3)
    Protein GST-23 (gst-23) mRNA, complete cds
    (see all 3)
    33(a)
    32(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9058904-9060183) WBGene00001749
    V(3243295-3244494) WBGene00001771


    ENSEMBL Gene Tree for GSTM3 (if available)
    TreeFam Gene Tree for GSTM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GSTM3 gene
    GSTP12  GSTM42  GSTM12  GSTM52  GSTM22  
    6 SIMAP similar genes for GSTM3 using alignment to 3 protein entries:     GSTM3_HUMAN (see all proteins):
    GSTmu3    GSTM4    GSTM1    GSTM5    GSTM2    GSTP1

    GSTM3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GSTM3
    PGOHUM00000247610 PGOHUM00000240402


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GSTM3 (see all 241)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912825351,2
    --110276163(+) GGTGGC/TCGTGT 2 -- ds50010--------
    rs1510388381,2
    --110276231(+) ATGGAG/TGGCCT 2 -- ds50010--------
    rs560843611,2
    C,F--110276263(-) ATAGCG/ATCAGT 2 -- ds50016Minor allele frequency- A:0.02NS NA 300
    rs1396725341,2
    C--110276275(+) AACAAC/TTACAC 2 -- ds50010--------
    rs1435033201,2
    --110276340(+) GGATGA/TCACAC 2 -- ds50010--------
    rs1837328201,2
    --110276548(+) ACATGA/GACATG 2 -- ds50010--------
    rs563283141,2
    C,F--110276565(-) CTGCCC/TTACTC 2 -- ut31 nc-transcript-variant7Minor allele frequency- T:0.04NS WA 308
    rs1869600431,2
    --110276573(+) CAGAGG/TAGAAT 2 -- ut31 nc-transcript-variant0--------
    rs562462621,2
    C,F--110276772(-) AGATGG/CAGTCC 2 -- ut31 nc-transcript-variant7Minor allele frequency- C:0.04NS WA 310
    rs1125645051,2
    F--110276809(+) AAAACC/TCATGG 2 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for GSTM3 (110276554 - 110284384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872143CNV Loss21882294

    Human Gene Mutation Database (HGMD): GSTM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTM3
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 138390    OMIM disorders: --

    Selected diseases for GSTM3 (see all 57):    
    About MalaCards
    bronchogenic carcinoma    oral cancer    malignant pleural mesothelioma    oral leukoplakia
    barrett's adenocarcinoma    pharyngitis    hereditary pancreatitis    leukoplakia
    kidney cancer    non-hodgkin lymphoma    gallbladder cancer    stomach cancer
    laryngitis    primary open angle glaucoma    open-angle glaucoma    lung cancer susceptibility
    laryngeal carcinoma    sporadic breast cancer    hodgkin's lymphoma    laryngeal squamous cell carcinoma


    GSTM3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for GSTM3 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laryngeal squamous cell carcinoma 55.6 1 19922706 (1)
    pharyngeal cancer 53.9 3 10077151 (2), 10407823 (1)
    carcinoma basal cell 45.1 2 8616834 (2)
    oral cancer 42.3 10 12016153 (3), 10762000 (3), 14735473 (2)
    laryngeal cancer 40.9 4 10067818 (2), 12359356 (1), 10407823 (1)
    cancer 40.5 12 14735473 (3), 10022746 (2), 16760134 (1), 8616834 (1) (see all 8)
    cancer lung 31.9 6 9918133 (3), 7614465 (1), 7728947 (1)
    carcinoma squamous cell 25.5 2 12548461 (1), 10498401 (1)
    neck cancer 22.7 1 10407823 (1)
    breast cancer 17.5 3 19856098 (2), 12888106 (1)

    Genetic Association Database (GAD): GSTM3
    Human Genome Epidemiology (HuGE) Navigator: GSTM3 (116 documents)

    Export disorders for GSTM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GSTM3 gene, integrated from 10 sources (see all 195):
    (articles sorted by number of sources associating them with GSTM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PubMed id 17372252)1, 4, 7, 9 Schwartzbaum J.A....Feychting M. (amp 2007)
    2. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. (PubMed id 17617661)1, 4, 7 Moore L.E....Chow W.H. (Carcinogenesis 2007)
    3. A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. (PubMed id 2345169)1, 2, 3 Campbell E.... Listowsky I. (J. Biol. Chem. 1990)
    4. A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. (PubMed id 18423940)1, 4, 9 Maes O.C....Wang E. (Neurobiol. Aging 2010)
    5. Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. (PubMed id 19856098)1, 4, 9 Yu K.D....Shao Z.M. (Breast Cancer Res. Treat. 2010)
    6. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. (PubMed id 18177825)1, 4, 9 Singh H....Mittal B. (Am. J. Obstet. Gynecol. 2008)
    7. Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. (PubMed id 14735473)1, 4, 9 Sikdar N....Roy B. (Int. J. Cancer 2004)
    8. Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. (PubMed id 11173863)1, 4, 9 Schnakenberg E....Schloot W. (Cytogenet. Cell Genet. 2000)
    9. Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms. (PubMed id 14968442)1, 4, 9 Medeiros R....Lopes C. (Prostate 2004)
    10. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PubMed id 15338373)1, 4, 9 Schneider A....Whitcomb D.C. (J. Gastroenterol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2947 HGNC: 4635 AceView: GSTM3 Ensembl:ENSG00000134202 euGenes: HUgn2947
    ECgene: GSTM3 Kegg: 2947 H-InvDB: GSTM3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GSTM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTM3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GSTM3 gene:
    Search GeneIP for patents involving GSTM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GSTM3  
     OriGene qPCR primer pairs and template standards for GSTM3   OriGene Protein Over-expression Lysate for GSTM3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GSTM3  
     OriGene qSTAR qPCR primer pairs in human, mouse for GSTM3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GSTM3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GSTM3   OriGene Custom Protein Services for GSTM3  

     
     
     Block miRNA regulation of human, mouse, rat GSTM3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GSTM3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTM3 Predesigned siRNA for gene silencing in human, mouse, rat GSTM3
     QuantiFast Probe-based Assays in human, mouse, rat GSTM3 QuantiTect SYBR Green Assays in human, mouse, rat GSTM3
     PCR Arrays including human, mouse, rat GSTM3 Search Chromatin IP Primers for GSTM3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTM3  GeneGlobe Interaction Network for GSTM3
     Regulatory tfbs in GSTM3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GSTM3 GenScript cDNA clones with any tag delivered in your preferred vector for GSTM3
     GenScript Custom Assay Services for GSTM3 GenScript Custom overexpressing Cell Line Services for GSTM3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GSTM3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GSTM3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GSTM3 antibodies
     GSTM3 proteins
     GSTM3 lysates
     Antibodies for GSTM3
     See all of Abcam's Antibodies, Kits and Proteins for GSTM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GSTM3
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GSTM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GSTM3
     SwitchGear Promoter luciferase reporter plasmids for GSTM3
     Search ThermoFisher Antibodies for GSTM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTM3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTM3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTM3
     LSBio Antibodies in human, mouse, rat for GSTM3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GSTM3 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4