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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTM2 Gene

protein-coding GIFtS: 61
GCID: GC01P110210

glutathione S-transferase mu 2 (muscle)

(Previous name: glutathione S-transferase M2 (muscle) )

Explore 18 diseases affiliated with
GSTM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutathione S-Transferase Mu 2 (Muscle)¹ ²		Glutathione S-Alkyltransferase M2²
GST4¹ ² ³ ⁵		Glutathione S-Aralkyltransferase M2²
Glutathione S-Transferase M2 (Muscle)¹ ²		Glutathione S-Aryltransferase M2²
GSTM2-2² ³		Glutathione S-Transferase 4²
GST Class-Mu 2² ³		Glutathione S-Transferase M1²
EC 2.5.1.18³ ⁸		Glutathione S-Transferase Mu 2²
GSTM²		GST, Muscle²
GTHMUS²		S-(Hydroxyalkyl)Glutathione Lyase M2²

External Ids:	HGNC: 4634¹	Entrez Gene: 2946²	Ensembl: ENSG00000213366⁷	OMIM: 138380⁵	UniProtKB: P28161³

Export aliases for GSTM2 gene to outside databases

Previous GC identifers: GC01P110689 GC01P109140 GC01P109312 GC01P109509 GC01P109922 GC01P110013 GC01P108098

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTM2:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At

present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified:

alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the

mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens,

therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes

encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly

polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as

affect the toxicity and efficacy of certain drugs. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

summary for GSTM2:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTM2 gene promoter:
AP-1 FOXO4 ATF-2 c-Jun HNF-3beta NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTM2 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3

GSTM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P110210: view genomic region (about GC identifiers)

Start:	110,210,644 bp from pter	End:	110,252,173 bp from pter
Size:	41,530 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161 (See protein sequence)

Recommended Name: Glutathione S-transferase Mu 2

Size: 218 amino acids; 25745 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

6/10 PDB 3D structures from and Proteopedia for GSTM2 (see all 10):

1HNA (3D)

1HNB (3D)

1HNC (3D)

1XW5 (3D)

1YKC (3D)

2AB6 (3D)

Secondary accessions: B4DRY4 E9PEM9 Q2M318 Q5TZY5 Q8WWE1

Alternative splicing: 2 isoforms: P28161-1 P28161-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GSTM2: NX_P28161

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28161

4/13 DME Specific Peptides for GSTM2 (P28161) (see all 13)

SRFLPRP

WLNEKFK

KISAYMK

FPNLKDF

GSTM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000839.1 NP_001135840.1

ENSEMBL proteins:

ENSP00000358846 ENSP00000435910 ENSP00000241337 ENSP00000435157 ENSP00000404662

ENSP00000358844 ENSP00000416883 ENSP00000358842

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	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	8373352
GO:0016529	sarcoplasmic reticulum	IDA	--

GSTM2 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTM2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012336 Thioredoxin-like_fold

IPR003081 GST_mu

IPR004046 GST_C

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR004045 Glutathione_S-Trfase_N

Graphical View of Domain Structure for InterPro Entry P28161

ProtoNet protein and cluster: P28161

2 Blocks protein families:

IPB003081 Mu-class glutathione S-transferase signature

IPB004045 Glutathione S-transferase

UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161

Similarity: Belongs to the GST superfamily. Mu family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Genatlas biochemistry entry for GSTM2:

glutathione-S-transferase 2 ,mu class,expressed in muscle

Enzyme Number (IUBMB): EC 2.5.1.18¹ ²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IDA	8373352
GO:0005102	receptor binding	IPI	--
GO:0019899	enzyme binding	IPI	8373352
GO:0042803	protein homodimerization activity	IPI	8373352
GO:0043295	glutathione binding	IDA	8373352

GSTM2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GSTM2:

Proliferating cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

	Glutathione metabolism	1.00			Glutathione metabolism	0.70
	Glutathione metabolism	0.92			Glutathione metabolism	0.44

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GSTM2

Glutathione metabolism

1 GeneGo (Thomson Reuters) Pathway for GSTM2

Glutathione metabolism

2 BioSystems Pathways for GSTM2

	metapathway biotransformation
	Glutathione metabolism

3 Kegg Pathways (Kegg details for GSTM2):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

GSTM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GSTM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/63 Interacting proteins for GSTM2 (P28161³ ENSP00000241337⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSTM3	P21266³, ENSP00000256594⁴	I2D: score=2 STRING: ENSP00000256594
GSTM1	P09488³, ENSP00000311469⁴	I2D: score=2 STRING: ENSP00000311469
TECPR1	Q7Z6L1³	I2D: score=1
GSTA2	ENSP00000420168⁴	STRING: ENSP00000420168
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006749	glutathione metabolic process	IDA	8373352
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	17023043
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC	17023043
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	IC	17023043
GO:0018916	nitrobenzene metabolic process	IDA	8373352

GSTM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSTM2 for compounds About GeneDecksing

EMD Millipore small molecules for GSTM2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTM2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

10/12 HMDB Compounds for GSTM2 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

4 DrugBank Compounds for GSTM2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17498936 17490601 17523921 17553661 17604895
Glutathione S-(2,4 Dinitrobenzene)	--	26289-39-4	target	--	17139284 17016423
Oxidized Glutathione Disulfide	--	--	target	--	17139284 17016423
S-METHYL-GLUTATHIONE	--	--	target	--	--

4 Novoseek chemical compound relationships for GSTM2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	80.4	2	12896903 (2)
1-chloro-24-dinitrobenzene	60.6	4	17071629 (1), 12896903 (1)
epoxide	50.9	1	12029283 (1)
oxygen	5.42	1	18008142 (1)

Search CenterWatch for drugs/clinical trials and news about GSTM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTM2 gene (2 alternative transcripts):

NM_000848.3 NM_001142368.1

Unigene Cluster for GSTM2:

Glutathione S-transferase mu 2 (muscle)

Hs.279837 [show with all ESTs]

Unigene Representative Sequence: BF304608

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369831 ENST00000460717 ENST00000464206 ENST00000481656 ENST00000476040

ENST00000241337(uc001dyi.3 uc001dyj.3) ENST00000467579 ENST00000414179

ENST00000369829 ENST00000568786 ENST00000472225 ENST00000496578 ENST00000581919

ENST00000442650(uc010ovt.2 uc009wfk.3) ENST00000369827

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Additional cDNA sequence:

AK309796.1 BC105038.1 BC105066.1 BC110380.1 BT019947.1 M63509.1

24/29 DOTS entries (see all 29):

DT.92457648 DT.102835605 DT.95264463 DT.100781293 DT.86668179 DT.92035903 DT.121350175 DT.95078978

DT.100781291 DT.100805854 DT.101985451 DT.95264450 DT.102835603 DT.91756641 DT.100032881 DT.100666629

DT.100773257 DT.100781295 DT.95278349 DT.95278587 DT.100666628 DT.121350192 DT.121350195 DT.121350242

24/28 AceView cDNA sequences (see all 28):

CR593978 CR620137 CR605552 BM663884 F04245 CD014121 CR610968 F33485

AW239463 BQ881158 BI912908 CR605073 BQ925142 BM705078 BF876413 CD609663

BI767629 BI916324 NM_000848 CR613986 F26251 CR614262 CR602220 BE170223

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

GSTM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GSTM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTM2

SOURCE GeneReport for Unigene cluster: Hs.279837

UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161

Tissue specificity: Muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including GSTM2:

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GSTM2 gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	68(a) 67(a) (see all 3)	possible ortholog possible ortholog (see all 3)	4(105944541-105950815) 4(105963341-105964741)
zebrafish (Danio rerio)	Actinopterygii	gstm3⁶ zgc:173994⁶ (see all 3)	zgc:173994 (see all 3)	65(a) 63(a) (see all 3)	many ↔ many many ↔ many (see all 3)	8(26155115-26159957) 8(26152012-26154745)

ENSEMBL Gene Tree for GSTM2 (if available)
TreeFam Gene Tree for GSTM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSTM2 gene

GSTA4² GSTA5² GSTA3² GSTA1² GSTM1² GSTM3² GSTA2² GSTP1²

GSTM4² HPGDS² GSTM5²

6 SIMAP similar genes for GSTM2 using alignment to 8 protein entries: GSTM2_HUMAN (see all proteins):

GSTmu3 GSTM1 GSTM5 GSTM3 GSTM4 GSTP1

GSTM2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GSTM2
PGOHUM00000237536 PGOHUM00000243327

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146299492^1,2		--	110208695(+)	`GATACC/TTTCTT`	2	--	us2k¹		0	--	--	--	--
rs187119596^1,2		--	110208945(+)	`CAAAAA/GTAAGT`	2	--	us2k¹		0	--	--	--	--
rs75047365^1,2	F,	--	110209022(+)	`AGGCTG/CCCTGT`	2	--	us2k¹		1		WA	118
rs72987094^1,2	C,	--	110209038(+)	`GAATAA/GTGTGC`	2	--	us2k¹		3		WA CSA	121
rs200217278^1,2		--	110209046(+)	`TGCTC-/AGAGCT`	2	--	us2k¹		0	--	--	--	--
rs114469222^1,2	F,	--	110209138(+)	`CTGTCC/TACCTG`	2	--	us2k¹		1		WA	118
rs191881737^1,2		--	110209236(+)	`CTAGGA/TCCTCC`	2	--	us2k¹		0	--	--	--	--
rs72987096^1,2	C,	--	110209313(+)	`ACCTTG/TTTTCT`	2	--	us2k¹		2		WA	120
rs641065^1,2	C,F,A,H,	--	110209434(-)	`GGAGGC/TGGAGG`	2	--	us2k¹		9		NA WA CSA	19
rs473682^1,2	C,F,A,H,	--	110209441(-)	`GAACCG/AGGGAG`	2	--	us2k¹		8		NA WA CSA	18

HapMap Linkage Disequilibrium report for GSTM2 (110210644 - 110252173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for GSTM2
14 CNVs: 84464 37827 64585 34680 30400 74639 34681 64584 34682 84466 74641 0385 74640 84467

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GSTM2 for disorders           About GeneDecksing

OMIM gene information: 138380    OMIM disorders: --

18 diseases for GSTM2:    About MalaCards

lactic acidosis breast cancer susceptibility barrett's adenocarcinoma breast cancer

diabetes mellitus teratoma rheumatoid arthritis endocarditis

hepatocellular carcinoma arthritis lung carcinoma colorectal cancer

lung cancer adenocarcinoma atherosclerosis hypertension

carcinoma hepatitis

1 disease from the University of Copenhagen DISEASES database for GSTM2:

Rheumatoid arthritis

2 Novoseek disease relationships for GSTM2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	7.23	5	19859803 (3)
tumors	0.501	1	19900515 (1)

Human Genome Epidemiology (HuGE) Navigator: GSTM2 (17 documents)

Export disorders for GSTM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GSTM2 gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with GSTM2)

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Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. (PubMed id 2034681)^{1, 2, 3, 9} Vorachek W.R.... Rule G.S. (1991)
Alternative mutations of a positively selected residu e elicit gain or loss of functionalities in enzyme evolution. (PubMed id 16549767)^{1, 2} NorrgAYrd M.A....Mannervik B. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity. (PubMed id 8182750)^{1, 2} Raghunathan S.... Rule G.S. (1994)
Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. (PubMed id 8373352)^{1, 2} Ross V.L. and Board P.G. (1993)
A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. (PubMed id 2345169)^{1, 3} Campbell E.... Listowsky I. (1990)
No evidence for glutathione S-transferases GSTA2, GST M2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PubMed id 19859803)^{1, 9} Andonova I.E....Brauch H. (2010)
Structural basis for the binding of the anticancer co mpound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-t ransferases. (PubMed id 19808963)^{2, 9} Federici L....Caccuri A.M. (2009)
Glutathione S-transferase variants and hypertension. (PubMed id 18551009)^{1, 9} Delles C....Dominiczak A.F. (2008)
Alleviation of benzo[a]pyrene-diolepoxide-DNA damage in human lung carcinoma by glutathione S-transferase M2. (PubMed id 15725629)^{1, 9} Weng M.W....Ko J.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2946	HGNC: 4634	AceView: GSTM2	Ensembl:ENSG00000213366	euGenes: HUgn2946
ECgene: GSTM2	Kegg: 2946	H-InvDB: GSTM2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GSTM2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GSTM2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GSTM2 gene
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Patent Information for GSTM2 gene:
Search GeneIP for patents involving GSTM2

GeneCards and IP:
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glutathione S-transferase mu 2 (muscle)

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glutathione S-transferase mu 2 (muscle)

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