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GSTM2 Gene

protein-coding   GIFtS: 64
GCID: GC01P110210

Glutathione S-Transferase Mu 2 (Muscle)

(Previous name: glutathione S-transferase M2 (muscle))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Mu 2 (Muscle)1 2     Glutathione S-Alkyltransferase M22
GST42 3 5     Glutathione S-Aralkyltransferase M22
Glutathione S-Transferase M2 (Muscle)1 2     Glutathione S-Aryltransferase M22
GSTM2-22 3     Glutathione S-Transferase 42
GST Class-Mu 22 3     Glutathione S-Transferase M12
EC 2.5.1.183 8     Glutathione S-Transferase Mu 22
GSTM2     GST, Muscle2
GTHMUS2     S-(Hydroxyalkyl)Glutathione Lyase M22

External Ids:    HGNC: 46341   Entrez Gene: 29462   Ensembl: ENSG000002133667   OMIM: 1383805   UniProtKB: P281613   

Export aliases for GSTM2 gene to outside databases

Previous GC identifers: GC01P110689 GC01P109140 GC01P109312 GC01P109509 GC01P109922 GC01P110013 GC01P108098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTM2 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At
present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been
identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase
that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds,
including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation
with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3
and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to
carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. (provided by RefSeq, Jul
2008)

GeneCards Summary for GSTM2 Gene:
GSTM2 (glutathione S-transferase mu 2 (muscle)) is a protein-coding gene. Diseases associated with GSTM2 include barrett's adenocarcinoma, and endocarditis. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is GSTP1.

UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles

Gene Wiki entry for GSTM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTM2 gene promoter:
         AP-1   FOXO4   ATF-2   c-Jun   HNF-3beta   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTM2 promoter sequence
   Search Chromatin IP Primers for GSTM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

GSTM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110210:  view genomic region     (about GC identifiers)

Start:
110,210,644 bp from pter      End:
110,252,171 bp from pter
Size:
41,528 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161 (See protein sequence)
Recommended Name: Glutathione S-transferase Mu 2  
Size: 218 amino acids; 25745 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for GSTM2 (see all 10):
1HNA (3D)        1HNB (3D)        1HNC (3D)        1XW5 (3D)        1YKC (3D)        2AB6 (3D)    
Secondary accessions: B4DRY4 E9PEM9 Q2M318 Q5TZY5 Q8WWE1
Alternative splicing: 2 isoforms:  P28161-1   P28161-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GSTM2: NX_P28161

Explore proteomics data for GSTM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTM2 (P28161) (see all 13)
     SRFLPRP  WLNEKFK  KISAYMK  FPNLKDF 


    See GSTM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000839.1  NP_001135840.1  

    ENSEMBL proteins: 
     ENSP00000358846   ENSP00000435910   ENSP00000241337   ENSP00000435157   ENSP00000404662  
     ENSP00000358844   ENSP00000416883   ENSP00000358842  
    Reactome Protein details: P28161

    GSTM2 Human Recombinant Protein Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003081 GST_mu
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P28161

    ProtoNet protein and cluster: P28161

    2 Blocks protein domains:
    IPB003081 Mu-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161
    Similarity: Belongs to the GST superfamily. Mu family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTM2_HUMAN, P28161
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTM2:
    glutathione-S-transferase 2 ,mu class,expressed in muscle

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA16549767
    GO:0005102receptor binding IPI--
    GO:0005515protein binding ----
    GO:0019899enzyme binding IPI8373352
    GO:0042803protein homodimerization activity IPI8373352
         
    GSTM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTM2:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTM2

    miRNA
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    miRTarBase miRNAs that target GSTM2:
    hsa-mir-181a-5p (MIRT025057)

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    GenScript: all cDNA clones in your preferred vector (see all 2): GSTM2 (NM_000848)
    Sino Biological Human cDNA Clone for GSTM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTM2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTM2_HUMAN, P28161: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    cytoskeleton3
    cytosol3
    nucleus3
    mitochondrion2
    peroxisome2
    plasma membrane2
    extracellular1
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA2034681
    GO:0005829cytosol TAS--
    GO:0016529sarcoplasmic reticulum IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    GSTM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GSTM2
        Glutathione metabolism

    2 BioSystems Pathways for GSTM2
        metapathway biotransformation
    Glutathione metabolism


    1 Reactome Pathway for GSTM2
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for GSTM2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTM2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTM2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSTM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTM2 (P281613 ENSP000002413374) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTM3P212663, ENSP000002565944I2D: score=2 STRING: ENSP00000256594
    GSTM1P094883, ENSP000003114694I2D: score=2 STRING: ENSP00000311469
    TECPR1Q7Z6L13I2D: score=1 
    GSTA2ENSP000004201684STRING: ENSP00000420168
    ADH1AENSP000002096684STRING: ENSP00000209668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA16549767
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA17023043
    GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC17023043
    GO:0014809regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC17023043

    GSTM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTM2

    Selected HMDB Compounds for GSTM2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    4 DrugBank Compounds for GSTM2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17498936 17490601 17523921 17553661 17604895
    Glutathione S-(2,4 Dinitrobenzene)-- 26289-39-4target--17139284 17016423
    Oxidized Glutathione Disulfide-- --target--17139284 17016423
    S-METHYL-GLUTATHIONE-- --target----

    4 Novoseek inferred chemical compound relationships for GSTM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 80.4 2 12896903 (2)
    1-chloro-24-dinitrobenzene 60.6 4 17071629 (1), 12896903 (1)
    epoxide 50.9 1 12029283 (1)
    oxygen 5.42 1 18008142 (1)



    GSTM2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GSTM2 gene (2 alternative transcripts): 
    NM_000848.3  NM_001142368.1  

    Unigene Cluster for GSTM2:

    Glutathione S-transferase mu 2 (muscle)
    Hs.279837  [show with all ESTs]
    Unigene Representative Sequence: BF304608
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369831 ENST00000460717 ENST00000464206 ENST00000481656 ENST00000476040
    ENST00000241337(uc001dyi.3 uc001dyj.3) ENST00000467579 ENST00000414179
    ENST00000369829 ENST00000568786 ENST00000472225 ENST00000496578 ENST00000442650(uc010ovt.2 uc009wfk.3)
    ENST00000369827
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    Additional mRNA sequence: 

    AK309796.1 BC105038.1 BC105066.1 BC110380.1 BT019947.1 M63509.1 

    Selected DOTS entries (see all 29):

    DT.92457648  DT.102835605  DT.95264463  DT.100781293  DT.86668179  DT.92035903  DT.121350175  DT.95078978 
    DT.100781291  DT.100805854  DT.101985451  DT.95264450  DT.102835603  DT.91756641  DT.100032881  DT.100666629 
    DT.100773257  DT.100781295  DT.95278349  DT.95278587  DT.100666628  DT.121350192  DT.121350195  DT.121350242 

    Selected AceView cDNA sequences (see all 28):

    CD609663 BI912908 BM705078 F04245 BQ881158 CF127086 BI916324 CR605073 
    BQ925142 CR605552 AW239463 NM_000848 CR613986 CR593978 BF876413 F26251 
    CR602220 BE170223 F33485 BI767629 CR614262 H39118 CR620137 CR610968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GSTM2 Expression
    About this image


    GSTM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Thymus (Hematopoietic System)
             Thymus
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    GSTM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279837

    UniProtKB/Swiss-Prot: GSTM2_HUMAN, P28161
    Tissue specificity: Muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTM2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTM2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstm25
    Gstm71
    glutathione S-transferase, mu 25
    glutathione S-transferase, mu 71
    84.18(n)1
    83.41(a)1
      3 (46.83 cM)5
    683121  NM_026672.21  NP_080948.21 
     1079817025 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    69(a)
    69(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(105979841-105989135)
    4(105944541-105950815)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739946
    gstm6
    (see all 3)
    glutathione S-transferase M
    (see all 3)
    64(a)
    63(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    8(26152012-26154745) ENSDARG00000029473
    8(26148103-26150871) ENSDARG00000042533
    worm
    (Caenorhabditis elegans)
    Secernentea gst-236
    gst-16
    (see all 3)
    Protein GST-1 (gst-1) mRNA, complete cds
    (see all 3)
    29(a)
    29(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(3243295-3244494) WBGene00001771
    III(9058904-9060183) WBGene00001749


    ENSEMBL Gene Tree for GSTM2 (if available)
    TreeFam Gene Tree for GSTM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTM2 gene
    GSTP12  GSTM42  GSTM12  GSTM32  GSTM52  
    6 SIMAP similar genes for GSTM2 using alignment to 8 protein entries:     GSTM2_HUMAN (see all proteins):
    GSTmu3    GSTM1    GSTM5    GSTM4    GSTM3    GSTP1

    GSTM2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GSTM2
    PGOHUM00000237536 PGOHUM00000243327


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTM2 (see all 427)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462994921,2
    --110208695(+) GATACC/TTTCTT 2 -- us2k10--------
    rs1871195961,2
    --110208945(+) CAAAAA/GTAAGT 2 -- us2k10--------
    rs750473651,2
    F--110209022(+) AGGCTG/CCCTGT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs729870941,2
    C,F--110209038(+) GAATAA/GTGTGC 2 -- us2k13Minor allele frequency- G:0.26WA CSA 121
    rs2002172781,2
    --110209046(+) TGCTC-/AGAGCT 2 -- us2k10--------
    rs1144692221,2
    F--110209138(+) CTGTCC/TACCTG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1918817371,2
    C--110209236(+) CTAGGA/TCCTCC 2 -- us2k10--------
    rs729870961,2
    C,F--110209313(+) ACCTTG/TTTTCT 2 -- us2k12Minor allele frequency- T:0.05WA 120
    rs6410651,2
    C,F,A,H--110209434(-) ggaggC/Tggagg 2 -- us2k19Minor allele frequency- T:0.26NA WA CSA 19
    rs4736821,2
    C,F,A,H--110209441(-) gaaccG/Agggag 2 -- us2k18Minor allele frequency- A:0.33NA WA CSA 18

    HapMap Linkage Disequilibrium report for GSTM2 (110210644 - 110252171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GSTM2 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003982CNV Deletion20482838
    dgv61e199CNV Deletion23128226
    nsv820548CNV Deletion20802225
    nsv2321CNV Insertion18451855
    nsv276CNV Loss15895083
    nsv824076CNV Loss20364138
    nsv2310CNV Loss18451855
    dgv3n47CNV Loss21111241
    nsv872143CNV Loss21882294
    nsv508471CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTM2
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138380    OMIM disorders: --

    14 diseases for GSTM2:    
    About MalaCards
    barrett's adenocarcinoma    endocarditis    lactic acidosis    teratoma
    transitional cell carcinoma    breast cancer    diabetes mellitus    atherosclerosis
    hypertension    lung cancer    colorectal cancer    hepatocellular carcinoma
    adenocarcinoma    hepatitis

    1 disease from the University of Copenhagen DISEASES database for GSTM2:
    Cancer

    GSTM2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GSTM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 7.23 5 19859803 (3)
    tumors 0.501 1 19900515 (1)

    Genetic Association Database (GAD): GSTM2
    Human Genome Epidemiology (HuGE) Navigator: GSTM2 (17 documents)

    Export disorders for GSTM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTM2 gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with GSTM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. (PubMed id 2034681)1, 2, 3, 9 Vorachek W.R.... Rule G.S. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PubMed id 19859803)1, 4, 9 Andonova I.E....Brauch H. (Breast Cancer Res. Treat. 2010)
    3. Glutathione S-transferase variants and hypertension. (PubMed id 18551009)1, 4, 9 Delles C....Dominiczak A.F. (J. Hypertens. 2008)
    4. Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. (PubMed id 19856098)1, 4, 9 Yu K.D....Shao Z.M. (Breast Cancer Res. Treat. 2010)
    5. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    6. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (amp 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. (PubMed id 19696791)1, 4 Tatemichi M....Tsugane S. (J. Hum. Genet. 2009)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    10. Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function. (PubMed id 19151192)1, 4 Breton C.V....Gilliland F.D. (Am. J. Respir. Crit. Care Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2946 HGNC: 4634 AceView: GSTM2 Ensembl:ENSG00000213366 euGenes: HUgn2946
    ECgene: GSTM2 Kegg: 2946 H-InvDB: GSTM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GSTM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTM2 gene:
    Search GeneIP for patents involving GSTM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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