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GSTM1 Gene

protein-coding   GIFtS: 70
GCID: GC01P110232

Glutathione S-Transferase Mu 1

(Previous name: glutathione S-transferase M1)
(Previous symbol: GST1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Mu 11 2     GTM12
GST11 2 3     H-B2
Glutathione S-Transferase M11 2     MU2
GSTM1-12 3     MU-12
GSTM1a-1a2 3     Glutathione S-Alkyltransferase2
GSTM1b-1b2 3     Glutathione S-Aralkyltransferase2
GTH42 3     Glutathione S-Aryltransferase2
GST Class-Mu 12 3     HB Subunit 42
GST HB Subunit 42 3     S-(Hydroxyalkyl)Glutathione Lyase2
EC 2.5.1.183 8     

External Ids:    HGNC: 46321   Entrez Gene: 29442   Ensembl: ENSG000001341847   OMIM: 1383505   UniProtKB: P094883   

Export aliases for GSTM1 gene to outside databases

Previous GC identifers: GC01P110709 GC01P109159 GC01P109332 GC01P109529 GC01P109942 GC01P110031 GC01P110231


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTM1 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At
present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been
identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase
that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds,
including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation
with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3
and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to
carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class
mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to
environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GSTM1 Gene:
GSTM1 (glutathione S-transferase mu 1) is a protein-coding gene. Diseases associated with GSTM1 include lung cancer, gstm1-related, and asbestosis. GO annotations related to this gene include glutathione transferase activity and protein homodimerization activity. An important paralog of this gene is GSTP1.

UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles

Gene Wiki entry for GSTM1 (Glutathione S-transferase Mu 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTM1 gene promoter:
         GR   AP-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTM1 promoter sequence
   Search Chromatin IP Primers for GSTM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

GSTM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTM1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110232:  view genomic region     (about GC identifiers)

Start:
110,230,418 bp from pter      End:
110,251,661 bp from pter
Size:
21,244 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488 (See protein sequence)
Recommended Name: Glutathione S-transferase Mu 1  
Size: 218 amino acids; 25712 Da
Subunit: Homodimer
5 PDB 3D structures from and Proteopedia for GSTM1:
1GTU (3D)        1XW6 (3D)        1XWK (3D)        1YJ6 (3D)        2F3M (3D)    
Secondary accessions: Q5GHG0 Q6FH88 Q8TC98 Q9UC96
Alternative splicing: 2 isoforms:  P09488-1   P09488-2   

Explore the universe of human proteins at neXtProt for GSTM1: NX_P09488

Explore proteomics data for GSTM1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys52
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTM1 (P09488) (see all 15)
     SRFLPRP  WLNEKFK  CGETEEE  KISAYMK 


    See GSTM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000552.2  NP_666533.1  

    ENSEMBL proteins: 
     ENSP00000311469   ENSP00000358838   ENSP00000234981   ENSP00000456315   ENSP00000455929  
     ENSP00000358834  
    Reactome Protein details: P09488

    GSTM1 Human Recombinant Protein Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003081 GST_mu
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P09488

    ProtoNet protein and cluster: P09488

    2 Blocks protein domains:
    IPB003081 Mu-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
    Similarity: Belongs to the GST superfamily. Mu family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTM1_HUMAN, P09488
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTM1:
    glutathione-S-transferase 1 ,mu class,deleted in lung and urinary bladder cancer (in dependance on the exposure to
    carcinogens as cigarette) and in childhood acute leukemia (null allele) in association with CYP1A1*2A

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA8373352
    GO:0005515protein binding ----
    GO:0019899enzyme binding IPI8373352
    GO:0042803protein homodimerization activity IPI8373352
    GO:0043295glutathione binding IDA8373352
         
    GSTM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTM1:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gstm1):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system 

    GSTM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GSTM1: Gstm1tm1Kfuj Gstm1tm1Gcw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTM1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTM1

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    GenScript: all cDNA clones in your preferred vector (see all 2): GSTM1 (NM_000561)
    Sino Biological Human cDNA Clone for GSTM1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTM1_HUMAN, P09488: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA8373352
    GO:0005829cytosol TAS--

    GSTM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTM1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione conjugation0.60
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Aflatoxin B1 metabolism0.00
    3Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    4Estrogen metabolism
    Estrogen metabolism0.43
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for GSTM1
        Naphthalene metabolism
    Glutathione metabolism

    Selected BioSystems Pathways for GSTM1 (see all 6)
        Aflatoxin B1 metabolism
    glutathione-mediated detoxification I
    Estrogen metabolism
    C-MYB transcription factor network
    Glutathione metabolism


    1 Reactome Pathway for GSTM1
        Glutathione conjugation

    3 PharmGKB Pathways for GSTM1
        Busulfan Pathway, Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    4 Kegg Pathways  (Kegg details for GSTM1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTM1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GSTM1
    Interactions:

        GeneGlobe Interaction Network for GSTM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTM1 (P094883 ENSP000003114694) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTM2P281613, ENSP000002413374I2D: score=2 STRING: ENSP00000241337
    MAP3K5Q996833, ENSP000003519084I2D: score=2 STRING: ENSP00000351908
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA8373352
    GO:0006805xenobiotic metabolic process TAS--
    GO:0018916nitrobenzene metabolic process IDA8373352
    GO:0042178xenobiotic catabolic process IDA8373352
    GO:0044281small molecule metabolic process TAS--

    GSTM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTM1

    Selected HMDB Compounds for GSTM1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    Selected DrugBank Compounds for GSTM1 (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17372252 17427177 17381051 17311259 17624589
    (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene-- --target--17139284 17016423 10592235
    (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene-- --target--17139284 17016423 10592235
    Fluorotryptophane-- 16626-02-1target--17139284 17016423 10592235
    Glutathione S-(2,4 Dinitrobenzene)-- 26289-39-4target--17139284 17016423
    Zinc Trihydroxide-- --target--17139284 17016423
    BusulfanBusulphan (see all 8)55-98-1enzymesubstrate8886613
    CisplatinCDDP (see all 7)15663-27-1enzymesubstrate11081456
    AzathioprineAzathioprin (see all 3)446-86-6enzymesubstrate--
    CarboplatinCBDCA (see all 2)41575-94-4enzymesubstrate--

    Selected Novoseek inferred chemical compound relationships for GSTM1 gene (see all 88)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 94.8 57 12411192 (4), 8203914 (3), 7703850 (2), 8280791 (2) (see all 41)
    epoxide 79.7 49 8406161 (2), 1423302 (1), 7923560 (1), 9718223 (1) (see all 44)
    1-hydroxypyrene 74.4 20 11641039 (4), 9800384 (4), 12919721 (2), 11323399 (2) (see all 10)
    mspi 73.2 27 8319207 (2), 10022748 (1), 10813720 (1), 15734083 (1) (see all 23)
    hydrocarbons 67.5 27 7627950 (2), 8970185 (1), 10026994 (1), 11045791 (1) (see all 25)
    1,3-butadiene 64.1 12 11397424 (2), 15036120 (1), 15093278 (1), 7728978 (1) (see all 8)
    s-phenylmercapturic acid 63 8 17885617 (2), 15533900 (1), 20100551 (1), 17056211 (1)
    styrene oxide 60.9 29 11948819 (4), 7728978 (4), 14698568 (3), 12016165 (2) (see all 6)
    arylamine 60.3 6 11741741 (1), 8639263 (1), 10845567 (1), 11505222 (1) (see all 5)
    acetylphenylhydrazine 60.2 4 8142220 (2), 2031830 (1)

    2 PharmGKB related drug/compound annotations for GSTM1 gene    About this table
    Drug/compound PharmGKB Annotation
    Drugs For Treatment Of TuberculosisCA  
    isoniazidCA  



    GSTM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GSTM1 gene (2 alternative transcripts): 
    NM_000561.3  NM_146421.2  

    Unigene Cluster for GSTM1:

    Glutathione S-transferase mu 1
    Hs.301961  [show with all ESTs]
    Unigene Representative Sequence: NM_000561
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490021 ENST00000309851(uc001dyk.3 uc001dyl.3) ENST00000369823
    ENST00000349334 ENST00000476065 ENST00000483399 ENST00000490171 ENST00000369819

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AY510272.1 AY532926.1 AY532927.1 BC024005.2 BC036805.1 BC095463.1 CR541868.1 J03817.1 
    X08020.1 

    21 DOTS entries:

    DT.100805854  DT.100781293  DT.86668179  DT.102835605  DT.121350242  DT.121350175  DT.92457648  DT.95264452 
    DT.121350239  DT.40115425  DT.95106574  DT.95214009  DT.100773257  DT.100805856  DT.120918240  DT.121350178 
    DT.121350192  DT.92035903  DT.92457641  DT.95264463  DT.97809747 

    12 AceView cDNA sequences:

    NM_146421 BI832608 NM_000561 BC024005 CA391532 BG253050 AV652616 BU180956 
    AA341764 BC036805 BM543431 BM977773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCTGCCT
    GSTM1 Expression
    About this image


    GSTM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
     
     Thymus (Hematopoietic System)
             Thymus
    GSTM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301961

    UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
    Tissue specificity: Liver (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTM1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstm15
    Gstm21
    glutathione S-transferase, mu 15
    glutathione S-transferase, mu 21
    85.78(n)1
    83.94(a)1
      3 (46.83 cM)5
    148631  NM_008183.31  NP_032209.11 
     1080122555 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    73(a)
    70(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(105979841-105989135)
    4(105944541-105950815)
    African clawed frog
    (Xenopus laevis)
    Amphibia gstm2-prov2 glutathione S-transferase, mu 2 74.09(n)    AJ416998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739946
    gstm6
    (see all 3)
    glutathione S-transferase M
    (see all 3)
    66(a)
    65(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    8(26152012-26154745) ENSDARG00000029473
    8(26148103-26150871) ENSDARG00000042533
    worm
    (Caenorhabditis elegans)
    Secernentea gst-16
    gst-236
    (see all 3)
    Protein GST-23 (gst-23) mRNA, complete cds
    (see all 3)
    31(a)
    30(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9058904-9060183) WBGene00001749
    V(3243295-3244494) WBGene00001771


    ENSEMBL Gene Tree for GSTM1 (if available)
    TreeFam Gene Tree for GSTM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTM1 gene
    GSTP12  GSTM42  GSTM32  GSTM52  GSTM22  
    6 SIMAP similar genes for GSTM1 using alignment to 6 protein entries:     GSTM1_HUMAN (see all proteins):
    GSTmu3    GSTM5    GSTM2    GSTM4    GSTM3    GSTP1

    GSTM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    GSTM1_HUMAN, P09488: There are two alleles; GSTM1A and GSTM1B which differ in position 173


    Selected SNPs for GSTM1 (see all 228)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814778781,2
    --110228557(+) CATCTA/GTTTCC 2 -- us2k10--------
    rs4215471,2
    C,F--110228567(-) ATGGAC/TATATG 2 -- us2k13Minor allele frequency- T:0.03MN NA 188
    rs4230331,2
    C,F--110228582(-) ATATTA/GCAAAT 2 -- us2k1 tfbs36Minor allele frequency- G:0.38NA CSA WA 125
    rs16342521,2
    C--110228690(-) CCTCCA/GCGAGA 2 -- us2k11Minor allele frequency- G:0.00NA 2
    rs66899021,2
    C--110228798(+) TCCGGA/CATGGT 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs362100911,2
    C--110228799(-) CACCAG/TTCCGG 2 -- us2k10--------
    rs362100901,2
    C--110228821(-) GGGACC/TCTCCC 2 -- us2k10--------
    rs2008857921,2
    C--110228903(+) GTTCT-/TTCT  
            
    GGCTT
    2 -- us2k10--------
    rs362100871,2
    C--110228913(-) TCAGAC/GAAGCC 2 -- us2k10--------
    rs362100841,2
    C--110228944(-) GTGACA/GCCTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GSTM1 (110230418 - 110251661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GSTM1 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003982CNV Deletion20482838
    esv2716040CNV Deletion23290073
    nsv820548CNV Deletion20802225
    dgv61e199CNV Deletion23128226
    nsv435675CNV Deletion17901297
    nsv2332CNV Insertion18451855
    nsv276CNV Loss15895083
    nsv824076CNV Loss20364138
    nsv437937CNV Loss16468122
    nsv2310CNV Loss18451855

    Human Gene Mutation Database (HGMD): GSTM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTM1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138350    OMIM disorders: --

    Selected diseases for GSTM1 (see all 236):    
    About MalaCards
    lung cancer, gstm1-related    asbestosis    leukoplakia    oral cancer
    senile cataract    benzene toxicity    primary open angle glaucoma    scabies
    lung cancer    cardia cancer    pharyngitis    drug-induced hepatitis
    open-angle glaucoma    esophageal cancer    lung cancer susceptibility    oral leukoplakia
    exfoliation syndrome    oral submucous fibrosis    rosacea    alcoholic liver cirrhosis

    7 diseases from the University of Copenhagen DISEASES database for GSTM1:
    Lung cancer     Urinary bladder cancer     Carcinoma     Colorectal cancer
    Breast cancer     Asthma     Leukemia

    GSTM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GSTM1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic susceptibility 77.4 27 18304461 (2), 10698723 (1), 10813720 (1), 11751440 (1) (see all 25)
    cancer lung 71.6 357 19428374 (6), 15105047 (6), 11062156 (6), 9855008 (6) (see all 99)
    cancer 67.8 218 9298582 (6), 12579293 (4), 8552885 (4), 10923314 (3) (see all 99)
    bladder cancer 66.5 162 10970445 (6), 10840461 (5), 18304215 (4), 8320745 (4) (see all 58)
    encephalopathy toxic chronic 61.2 2 14658041 (1), 14992466 (1)
    smoking habit 59.9 14 10753202 (1), 14556228 (1), 16099114 (1), 15596296 (1) (see all 10)
    environmental carcinogenesis 57.8 2 9788723 (1), 18463401 (1)
    oral cancer 54.8 62 12016153 (5), 19469619 (4), 11564581 (4), 10762000 (4) (see all 18)
    blond hair 53.9 3 17072629 (1), 11352862 (1)
    chromosomal aberrations 53.7 44 10984680 (3), 20464961 (3), 10207633 (3), 9804932 (2) (see all 26)

    Genetic Association Database (GAD): GSTM1
    Human Genome Epidemiology (HuGE) Navigator: GSTM1 (1537 documents)

    Export disorders for GSTM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTM1 gene, integrated from 10 sources (see all 2339):
    (articles sorted by number of sources associating them with GSTM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. (PubMed id 17624589)1, 4, 7, 9 Sakoda L.C....Chen C. (Breast Cancer Res. Treat. 2008)
    2. The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. (PubMed id 17381051)1, 4, 7, 9 Ouerhani S....ElgaaA^ed A.B. (Ann. Hum. Biol. 2006)
    3. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PubMed id 17372252)1, 4, 7, 9 Schwartzbaum J.A....Feychting M. (amp 2007)
    4. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. (PubMed id 11081456)1, 4, 7 Peters U....Lamprecht-Dinnesen A. (Anticancer Drugs 2000)
    5. Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype. (PubMed id 17187162)1, 4, 9 Aydemir B....Akyolcu M.C. (Asian J. Androl. 2007)
    6. [The effects of glutathione S-transferase (GSTT1 and GSTM1) genes polymorphisms on treatment efficacy and prognosis of acute myeloid leukemia]. (PubMed id 16624155)1, 4, 9 Zhang Y....Xiao Z.J. (Zhonghua Nei Ke Za Zhi 2006)
    7. Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics. (PubMed id 18056202)1, 4, 9 Moyer A.M....Weinshilboum R.M. (Clin. Cancer Res. 2007)
    8. Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma. (PubMed id 16235985)1, 4, 9 Tiwawech D....Ishida T. (Asian Pac. J. Cancer Prev. 2005)
    9. GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans. (PubMed id 20036620)1, 4, 9 Kim S.H....Jee Y.K. (Tuberculosis (Edinb) 2010)
    10. GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a case-control study in Jakarta, Indonesia. (PubMed id 19469619)1, 4, 9 Amtha R....Purwanto D. (Asian Pac. J. Cancer Prev. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2944 HGNC: 4632 AceView: GSTM1 Ensembl:ENSG00000134184 euGenes: HUgn2944
    ECgene: GSTM1 Kegg: 2944 H-InvDB: GSTM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSTM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTM1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=GSTM1[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTM1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTM1 gene:
    Search GeneIP for patents involving GSTM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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