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GSTM1 Gene

protein-coding   GIFtS: 69

GC01P110031
glutathione S-transferase mu 1
(Previous name: glutathione S-transferase M1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GST1)
Services    

Aliases &
Descriptions
for GSTM1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EC 2.5.1.18 3
GST1 2, 3
GSTM1-1 2, 3
GSTM1a-1a 2, 3
GSTM1b-1b 2, 3
GTH4 2, 3
GTM1 2
H-B 1, 2
MGC26563 2
MU 1, 2
MU-1 2
OTTHUMP00000013346 2
OTTHUMP00000013347 2
Descriptions
GST class-mu 1 2, 3
HB subunit 4 2, 3
S-(hydroxyalkyl)glutathione lyase 2
glutathione S-alkyltransferase 2
glutathione S-aralkyltransferase 2
glutathione S-aryltransferase 2
glutathione S-transferase M1 1, 2
glutathione S-transferase mu 1 2
External Ids
HGNC: 46321
Entrez Gene: 29442
UniProtKB: P094883
Ensembl: ENSG000001341847
Search outside databases for aliases for GSTM1 gene

Previous GC identifers: GC01P110709 GC01P109159 GC01P109332 GC01P109529 GC01P109942

Summaries
for GSTM1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for GSTM1:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct
supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian
glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and
zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of
enzymes functions in the detoxification of electrophilic compounds, including carcinogens,
therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with
glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on
chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an
individual's susceptibility to carcinogens and toxins as well as affect the toxicity and
efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase
in a number of cancers, likely due to an increased susceptibility to environmental toxins and
carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided
by RefSeq]

UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous
hydrophobic electrophiles

Gene Wiki entry for GSTM1 (Glutathione_S-transferase_Mu_1)

Genomic Location
for GSTM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GSTM1 gene  

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

GSTM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110031:     (about GC identifiers)

Start:
 110,031,965 bp from pter
End:
 110,037,890 bp from pter
Size:
 5,926 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.9  NT_019273.18  

Proteins
for GSTM1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488 (See protein sequence)
Recommended Name: Glutathione S-transferase Mu 1  
Size: 218 amino acids; 25712 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1GTU (3D)    1XW6 (3D)    1XWK (3D)    1YJ6 (3D)    2F3M (3D)    
Secondary accessions: Q5GHG0 Q6FH88 Q8TC98 Q9UC96
Alternative splicing: 2 isoforms:  P09488-1   P09488-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_000552.2  NP_666533.1  


    ENSEMBL proteins: 
    ENSP00000311469 ENSP00000234981 ENSP00000358838 ENSP00000358834 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for GSTM1  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (GSTM1 + GSTM2, GSTM1, Glutathione S Transferase mu)
    Human Recombinant Proteins from Abnova (GSTM1)
                  OriGene Purified Recombinant Human Protein: GSTM1 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for GSTM1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of GSTM1
    Sigma-Aldrich Antibodies for GSTM1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (GSTM1 + GSTM2, GSTM1, Glutathione S Transferase mu), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (GSTM1)
    Novus Biologicals Antibodies for GSTM1

    Assays for GSTM1: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of GSTM1
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for GSTM1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR003081 GST_mu
     IPR012335 Thioredoxin_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N


       GeneDecks  GSTM1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P09488

    ProtoNet protein and cluster: P09488

    2 Blocks protein families:
    IPB003081 Mu-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
    Similarity: Belongs to the GST superfamily. Mu family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain

    Gene Function
    for GSTM1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (GSTM1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GSTM1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000561

                  Applied Biosystems Silencer® siRNAs for GSTM1

                  Sigma-Aldrich siRNA and siRNA Panels for GSTM1  
                         Sigma-Aldrich shRNA for GSTM1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for GSTM1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000561
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000561
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000561 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000561

    UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous
    hydrophobic electrophiles
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Enzyme Number (IUBMB): EC 2.5.1.18 

    Genatlas biochemistry entry for GSTM1:
    glutathione-S-transferase 1 ,mu class,deleted in lung and urinary bladder cancer (in dependance on
    the exposure to carcinogens as cigarette) and in childhood acute leukemia (null allele) in
    association with CYP1A1*2A

    1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gstm1):

    homeostasis/metabolism

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364 glutathione transferase activity TAS8403204
    GO:0016740 transferase activity IEA--
    About this table

    Pathways & Interactions
    for GSTM1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for GSTM1
     Naphthalene metabolism
     Glutathione metabolism

       GeneDecks  GSTM1 for the pathways selected above  
    About GeneDecksing

    5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for  GSTM1  (Your Favorite Gene powered by Ingenuity) (see all 7 ) 
     Metabolism of Xenobiotics by Cytochrome P450
     Glutathione Metabolism
     Aryl Hydrocarbon Receptor Signaling
     NRF2-mediated Oxidative Stress Response
     PXR/RXR Activation

       GeneDecks  GSTM1 for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for GSTM1):
     hsa00480 Glutathione metabolism
     hsa00980 Metabolism of xenobiotics by cytochrome P450
     hsa00982 Drug metabolism - cytochrome P450

       GeneDecks  GSTM1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  GSTM1 


    5/74 Interacting proteins for GSTM1 (ENSP000003588383) via UniProtKB, MINT, and/or STRING (see all 74 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTT1ENSP000002489353STRING (score=.995)
    CYP1A1ENSP000003690503STRING (score=.988)
    GSTM2ENSP000003588453STRING (score=.986)
    EPHX1ENSP000003558023STRING (score=.984)
    GSTO1ENSP000003587273STRING (score=.976)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152 metabolic process IEA--
    About this table

    Drugs & Compounds
    for GSTM1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for GSTM1 available from Tocris Bioscience
    CompoundAction CAS number
    Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]
    About this table


    10/47 Novoseek chemical compound relationships for GSTM1 gene (see all 47 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 94.36 55 12411192 (4), 8203914 (3), 7703850 (2), 8280791 (2) (see all 39)
    epoxide 80.80 49 8406161 (2), 1423302 (1), 7923560 (1), 9718223 (1) (see all 44)
    1-hydroxypyrene 75.04 20 11641039 (4), 9800384 (4), 12919721 (2), 11323399 (2) (see all 10)
    mspi 73.22 26 8319207 (2), 10022748 (1), 10813720 (1), 15734083 (1) (see all 22)
    hydrocarbons 68.65 27 7627950 (2), 8970185 (1), 10026994 (1), 11045791 (1) (see all 25)
    1,3-butadiene 65.77 12 11397424 (2), 15036120 (1), 15093278 (1), 7728978 (1) (see all 8)
    styrene oxide 62.53 29 11948819 (4), 7728978 (4), 14698568 (3), 12016165 (2) (see all 6)
    acetylphenylhydrazine 61.27 4 8142220 (2), 2031830 (1)
    s-phenylmercapturic acid 60.85 6 17885617 (2), 15533900 (1), 17056211 (1)
    arylamine 60.27 6 11741741 (1), 8639263 (1), 10845567 (1), 11505222 (1) (see all 5)
    About this table

    10/15 PharmGKB drug compound relationships for GSTM1 gene (see all 15 )
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    asparaginaseCO  15713801
    chlorambucilFA  9685354
    cytarabineCO  15713801
    daunorubicinCO  15713801
    doxorubicinFA  9685354
    etoposideCO  FA  8763337 9685354 10673738 9057653 15713801
    fluorouracilCO  12072547
    mercaptopurineCO  15713801
    methotrexateCO  15713801
    mitoxantroneFA  9685354
    About this table


    Transcripts
    for GSTM1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (GSTM1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GSTM1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000561

                  Sigma-Aldrich siRNA and siRNA Panels for GSTM1  
                         Sigma-Aldrich shRNA for GSTM1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000561  NM_146421  

    REFSEQ mRNAs for GSTM1 gene (2 alternative transcripts): 

    NM_000561.3   NM_146421.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000561  NM_146421  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000561
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000561
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000561 

    Additional cDNA sequence: 

    AY510272.1 AY532926.1 AY532927.1 BC024005.2 BC036805.1 BC095463.1 CR541868.1 J03817.1 
    X08020.1 

    21 DOTS entries:

    DT.100805854  DT.100781293  DT.86668179  DT.102835605  DT.121350242  DT.121350175  DT.92457648  DT.95264452 
    DT.121350239  DT.40115425  DT.95106574  DT.95214009  DT.100773257  DT.120918240  DT.121350178  DT.121350192 
    DT.92035903  DT.92457641  DT.95153802  DT.95264463  DT.97809747 

    12 AceView cDNA sequences:

    BC036805 NM_000561 BI832608 NM_146421 AV652616 AA341764 CA391532 BC024005 
    BG253050 BU180956 BM543431 BM977773 

    highest scoring ESTs for GSTM1:

    BF881545 BG253050 BU180956 AA227608 AA341764 AA483995 AV652616 AY532927 BC024005 BE075760 

    Unigene Cluster for GSTM1:

    Glutathione S-transferase mu 1
    Hs.301961  [show with all ESTs]
    Unigene Representative Sequence: NM_000561


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000309851  ENST00000349334  ENST00000369823  ENST00000369819  

    Expression
    for GSTM1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GSTM1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GSTM1

    1 / 2 / 3

    8 probe-sets matching GSTM1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		39054_at2, 3 U95-A 4 1.00 0.35 0.99 1.00 X08020 0.80 0.83 0.82 1

    		556_s_at2, 3 U95-A 3 1.00 0.33 0.99 1.00 M96233 0.20 0.33 0.27 1

    		215333_x_at2, 3 U133-A 4 1.00 0.45 -- -- X08020 0.80 0.83 0.82 1

    		204550_x_at2, 3 U133-A 5 1.00 0.38 -- -- NM_000561 0.60 1.00 0.82 1

    		204418_x_at2 U133-A 6 1.00 0.36 -- -- -- -- -- -- --

    		215333_x_at2 U133Plus2 4 1.00 0.45 -- -- -- -- -- -- --

    		204550_x_at2 U133Plus2 5 1.00 0.38 -- -- -- -- -- -- --

    		204418_x_at2 U133Plus2 6 1.00 0.36 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTCCCTGCCT

    SOURCE GeneReport for Unigene cluster: Hs.301961

    Expression variation in blood from EXPOLDB for GSTM1

    UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
    Tissue specificity: Liver (at protein level)

    Orthologs
    for GSTM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for GSTM1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 GSTM11   -- glutathione S-transferase mu 1 84.71(n)
    81.19(a)    		 479912  XM_537038.2  XP_537038.2 
    chimpanzee
    (Pan troglodytes)    		 GSTM11   -- glutathione S-transferase mu 1 99.08(n)
    98.62(a)    		 745723  XM_001165021.1  XP_001165021.1 
    cow
    (Bos taurus)    		 GSTM11   -- glutathione S-transferase M1 85.17(n)
    83.94(a)    		 327709  NM_175825.3  NP_787019.1 
    rat
    (Rattus norvegicus)    		 Gstm21   -- glutathione S-transferase M2 83.64(n)
    81.65(a)    		 24424  NM_177426.1  NP_803175.1 
    mouse
    (Mus musculus)    		 Gstm15
    Gstm21    		 35
    		 glutathione S-transferase, mu 15
    glutathione S-transferase, mu 21    		 85.78(n)1
    83.94(a)1    		 148631  NM_008183.31  NP_032209.11 
     AC0790425  AL6718775  (see all 17)
    About this table        Species with no ortholog for GSTM1

    ENSEMBL Gene Tree for GSTM1

    Paralogs
    for GSTM1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GSTM1 gene
    GSTM42  GSTM32  GSTM52  GSTM22  

    SNPs/Variants
    for GSTM1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: GSTM1_HUMAN, P09488
    Polymorphism: There are two alleles; GSTM1A and GSTM1B which differ in position 173


    10/99 NCBI SNPs in GSTM1 are shown (see all 99 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 3)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs4125431,2
    		C,F,H110031467(-) ACTCCG/CAGGGC 2 -- ng514Minor allele frequency- C:0.10MN EU WA 608
    --
    rs38150291,2
    		A,C,F110031479(-) GATCCG/CAAAGC 2 -- ng516Minor allele frequency- C:0.41NA 274
    --
    rs4123021,2
    		C,F,O110031539(-) GGTGGT/CCCCAA 2 -- ng511Minor allele frequency- C:0.32MN 184
    --
    rs4215471,2
    		C,F110030090(-) ATGGAC/TATATG 2 -- ng511Minor allele frequency- T:0.03MN 184
    --
    rs66899021,2
    		C110030321(+) TCCGGA/CATGGT 2 -- ng510--------
    --
    rs41475631,2
    		C110031626(+) CACCGC/TGGGCA 2 -- ng510--------
    --
    rs22290571,2
    		F110037441(+) AGTARG/TGCCTT 2 -- ut310--------
    --
    rs4230331,2
    		C110030105(-) ATATTA/GCAAAT 2 -- ng51 tfbs30--------
    --
    rs41475621,2
    		C110031622(+) GGGACA/TCCGCG 2 -- ng510--------
    --
    rs6790051,2
    		C110031010(-) ccggtA/Tacagg 2 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for GSTM1 (up to first 250kb)

    Disorders & Mutations
    for GSTM1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 138350

    10/91 Novoseek disease relationships for GSTM1 gene (see all 91 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic susceptibility 76.84 25 18304461 (2), 10698723 (1), 10813720 (1), 11751440 (1) (see all 23)
    cancer lung 72.48 332 15105047 (6), 11062156 (6), 7563171 (6), 9855008 (6) (see all 99)
    cancer 67.94 210 9298582 (6), 12579293 (4), 8552885 (4), 10923314 (3) (see all 99)
    bladder cancer 67.53 157 10970445 (6), 10840461 (5), 18304215 (4), 8320745 (4) (see all 56)
    smoking habit 60.91 14 10753202 (1), 14556228 (1), 16099114 (1), 15596296 (1) (see all 10)
    environmental carcinogenesis 59.36 2 9788723 (1), 18463401 (1)
    encephalopathy toxic chronic 56.00 2 14658041 (1), 14992466 (1)
    blond hair 55.76 3 17072629 (1), 11352862 (1)
    carcinoma squamous cell 54.54 57 17221058 (4), 14662415 (2), 8330369 (2), 9568063 (2) (see all 44)
    chromosomal aberrations 54.09 38 10984680 (3), 10207633 (3), 9804932 (2), 16620556 (2) (see all 25)
    About this table

    6 PharmGKB disease relationships for GSTM1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Alzheimer's dementiaPD  PK  10801254
    Colorectal NeoplasmsCO  12072547 11773864
    Leukemia, Lymphocytic, AcuteCO  9057653
    Leukemia, Lymphocytic, Acute, L1CO  10673738 15713801
    Leukemia, Myelocytic, AcuteCO  10673738
    Neoplasms, Second PrimaryCO  10673738
    About this table

    Human Gene Mutation Database: GSTM1
    Genetic Association Database: GSTM1
    Human Genome Epidemiology Navigator: GSTM1 (1158 documents)

    Medical News
    for GSTM1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for GSTM1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/1659 PubMed articles for GSTM1 gene (see all 1659 ):

    Search for GSTM1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing GSTM1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 2944 HGNC: 4632 AceView: GSTM1 Ensembl:ENSG00000134184 euGenes: HUgn2944
    ECgene: GSTM1 H-InvDB: GSTM1

    Other Databases showing GSTM1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing GSTM1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for GSTM1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=GSTM1
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTM1

    Licensable Technologies
    for GSTM1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for GSTM1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GSTM1:
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