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Aliases for GSTK1 Gene

Aliases for GSTK1 Gene

  • Glutathione S-Transferase Kappa 1 2 3 5
  • GST Class-Kappa 3 4
  • GST 13-13 3 4
  • GSTK1-1 3 4
  • HGSTK1 3 4
  • Glutathione S-Transferase Subunit 13 Homolog 3
  • Glutathione S-Transferase Subunit 13 4
  • Glutathione S-Transferase K1 3
  • EC 2.5.1.18 4
  • GST13-13 3
  • GST13 3
  • GST 3

External Ids for GSTK1 Gene

Previous GeneCards Identifiers for GSTK1 Gene

  • GC00U913601
  • GC07U901487
  • GC07P142477
  • GC07P142670
  • GC07P142942
  • GC07P137297
  • GC07P143245
  • GC07P143248

Summaries for GSTK1 Gene

Entrez Gene Summary for GSTK1 Gene

  • This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GeneCards Summary for GSTK1 Gene

GSTK1 (Glutathione S-Transferase Kappa 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include receptor binding and glutathione transferase activity.

UniProtKB/Swiss-Prot for GSTK1 Gene

  • Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).

Gene Wiki entry for GSTK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTK1 Gene

Genomics for GSTK1 Gene

Regulatory Elements for GSTK1 Gene

Enhancers for GSTK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143300 0.9 Ensembl ENCODE 20.8 +57.1 57135 1.8 TAL1 BHLHE40 MAX MNT DPF2 GATA3 CTBP1 POLR2A IKZF1 FOSL2 GSTK1 LOC100507507 ZYX FAM131B CASP2 RN7SL481P HINT1P1
GH07F143345 1.2 Ensembl ENCODE 10.1 +101.7 101692 1.3 ATF1 GLI4 ZNF2 ZNF48 GLIS2 KLF7 KDM4B JUNB NFIL3 ZNF610 CLCN1 HINT1P1 ZYX LOC100507507 RN7SL535P CASP2 LOC105375545 TMEM139 EPHA1 EPHA1-AS1
GH07F143295 1 Ensembl ENCODE 12.1 +52.2 52225 2.1 SMARCE1 HDAC1 TAL1 JUN MAFG ZEB2 HIC1 ARID1B GATA3 JUND GSTK1 LOC100507507 ZYX FAM131B RN7SL481P RN7SL535P
GH07F143310 1 Ensembl ENCODE 11.5 +66.6 66595 0.6 CTCF ATF1 CBX3 RAD21 ZNF335 ZNF143 SMC3 ZMIZ1 ZSCAN29 CREM CASP2 LOC105375545 RN7SL535P TMEM139 GSTK1 FAM131B ZYX LOC100507507 EPHA1 EPHA1-AS1
GH07F143262 1.1 ENCODE 10.3 +20.0 20020 2.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC154761 GSTK1 TCAF2P1 TMEM139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GSTK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTK1 Gene

Chromosome:
7
Start:
143,244,093 bp from pter
End:
143,270,854 bp from pter
Size:
26,762 bases
Orientation:
Plus strand

Genomic View for GSTK1 Gene

Genes around GSTK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTK1 Gene

Proteins for GSTK1 Gene

  • Protein details for GSTK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Q3-GSTK1_HUMAN
    Recommended name:
    Glutathione S-transferase kappa 1
    Protein Accession:
    Q9Y2Q3
    Secondary Accessions:
    • B4DIH1
    • B4DSY2
    • Q6P4H0
    • Q7Z520
    • Q9P1S4

    Protein attributes for GSTK1 Gene

    Size:
    226 amino acids
    Molecular mass:
    25497 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTK1 Gene

    Alternative splice isoforms for GSTK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTK1 Gene

Post-translational modifications for GSTK1 Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for GSTK1
  • Santa Cruz Biotechnology (SCBT) Antibodies for GSTK1

No data available for DME Specific Peptides for GSTK1 Gene

Domains & Families for GSTK1 Gene

Gene Families for GSTK1 Gene

Protein Domains for GSTK1 Gene

Suggested Antigen Peptide Sequences for GSTK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2Q3

UniProtKB/Swiss-Prot:

GSTK1_HUMAN :
  • Belongs to the GST superfamily. Kappa family.
Family:
  • Belongs to the GST superfamily. Kappa family.
genes like me logo Genes that share domains with GSTK1: view

Function for GSTK1 Gene

Molecular function for GSTK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).

Enzyme Numbers (IUBMB) for GSTK1 Gene

Gene Ontology (GO) - Molecular Function for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004602 glutathione peroxidase activity IDA 14742434
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 25416956
GO:0015035 protein disulfide oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GSTK1: view
genes like me logo Genes that share phenotypes with GSTK1: view

Animal Models for GSTK1 Gene

MGI Knock Outs for GSTK1:

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTK1 Gene

Localization for GSTK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTK1 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTK1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
peroxisome 5
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005739 mitochondrion IEA,IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005777 peroxisome IEA,IDA 14742434
genes like me logo Genes that share ontologies with GSTK1: view

Pathways & Interactions for GSTK1 Gene

genes like me logo Genes that share pathways with GSTK1: view

Pathways by source for GSTK1 Gene

Gene Ontology (GO) - Biological Process for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IEA,IBA --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTK1: view

No data available for SIGNOR curated interactions for GSTK1 Gene

Drugs & Compounds for GSTK1 Gene

(6) Drugs for GSTK1 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Water Approved Pharma 0
GLUTATHIONE SULFINATE Experimental Pharma Target 0
LB42708 Pharma Selective FTase inhibitor, Selective farnesyltransferase (FTase) inhibitor 0
Lonafarnib Pharma Ftase inhibitor,potent and selective 0

(36) Additional Compounds for GSTK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTK1 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTK1: view

Transcripts for GSTK1 Gene

Unigene Clusters for GSTK1 Gene

Glutathione S-transferase kappa 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for GSTK1 Gene

GeneLoc Exon Structure for
GSTK1
ECgene alternative splicing isoforms for
GSTK1

Expression for GSTK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTK1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTK1 Gene



Protein tissue co-expression partners for GSTK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GSTK1 Gene:

GSTK1

SOURCE GeneReport for Unigene cluster for GSTK1 Gene:

Hs.390667

mRNA Expression by UniProt/SwissProt for GSTK1 Gene:

Q9Y2Q3-GSTK1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with GSTK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for GSTK1 Gene

Orthologs for GSTK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTK1 34 35
  • 96.61 (n)
dog
(Canis familiaris)
Mammalia GSTK1 34
  • 86.43 (n)
-- 35
  • 85 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia GSTK1 34 35
  • 81.71 (n)
rat
(Rattus norvegicus)
Mammalia Gstk1 34
  • 76.99 (n)
mouse
(Mus musculus)
Mammalia Gstk1 34 16 35
  • 73.3 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GSTK1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSTK1 34 35
  • 62.81 (n)
lizard
(Anolis carolinensis)
Reptilia GSTK1 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstk1 34
  • 61.99 (n)
zebrafish
(Danio rerio)
Actinopterygii gstk1 34 35
  • 56.54 (n)
GSTK1 (4 of 4) 35
  • 45 (a)
OneToMany
GSTK1 (3 of 4) 35
  • 43 (a)
OneToMany
GSTK1 (1 of 4) 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gstk-1 34 35
  • 46.57 (n)
gstk-2 35
  • 30 (a)
OneToMany
Species where no ortholog for GSTK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTK1 Gene

ENSEMBL:
Gene Tree for GSTK1 (if available)
TreeFam:
Gene Tree for GSTK1 (if available)

Paralogs for GSTK1 Gene

(1) SIMAP similar genes for GSTK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GSTK1: view

No data available for Paralogs for GSTK1 Gene

Variants for GSTK1 Gene

Sequence variations from dbSNP and Humsavar for GSTK1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10275885 -- 143,266,600(+) ctaac(C/T)ctttc intron-variant
rs1043436 -- 143,268,863(+) CTCTT(C/G)GTATA intron-variant, utr-variant-3-prime
rs111372296 -- 143,268,396(+) CTTGA(A/G)CCTGG intron-variant
rs111898377 -- 143,269,226(+) AGCCA(C/T)GCAGC intron-variant, downstream-variant-500B
rs112156550 -- 143,268,549(+) GAAGG(A/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTK1 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV loss 17160897
esv2735280 CNV deletion 23290073

Variation tolerance for GSTK1 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTK1 Gene

Human Gene Mutation Database (HGMD)
GSTK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTK1 Gene

Disorders for GSTK1 Gene

Relevant External Links for GSTK1

Genetic Association Database (GAD)
GSTK1
Human Genome Epidemiology (HuGE) Navigator
GSTK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTK1

No disorders were found for GSTK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTK1 Gene

Publications for GSTK1 Gene

  1. Gene and protein characterization of the human glutathione S- transferase kappa and evidence for a peroxisomal localization. (PMID: 14742434) Morel F. … Guillouzo A. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Modelling and bioinformatics studies of the human kappa class glutathione transferase predict a novel third glutathione transferase family with homology to prokaryotic 2-hydroxychromene-2-carboxylate (HCCA) isomerases. (PMID: 14709161) Robinson A. … Board P.G. (Biochem. J. 2004) 3 4 22 25 64
  3. Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. (PMID: 19225211) Gao F. … Xiang K. (Endocr. J. 2009) 3 46 64
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 46 64
  5. Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme. (PMID: 16081649) Li J. … Ding J. (Protein Sci. 2005) 3 4 64

Products for GSTK1 Gene

Sources for GSTK1 Gene

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