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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTK1 Gene

protein-coding GIFtS: 60
GCID: GC07P142942

glutathione S-transferase kappa 1

Explore 4 diseases affiliated with
GSTK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutathione S-Transferase Kappa 1¹ ²		GST²
GST13¹ ²		GST13-13²
GSTK1-1² ³		Glutathione S-Transferase K1²
GST 13-13² ³		Glutathione S-Transferase Subunit 13 Homolog²
GST Class-Kappa² ³		EC 2.5.1.18³
HGSTK1¹		Glutathione S-Transferase Subunit 13³

External Ids:	HGNC: 16906¹	Entrez Gene: 373156²	Ensembl: ENSG00000197448⁷	OMIM: 602321⁵	UniProtKB: Q9Y2Q3³

Export aliases for GSTK1 gene to outside databases

Previous GC identifers: GC00U913601 GC07U901487 GC07P142477 GC07P142670 GC07P137297

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTK1:

This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in

cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of

glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells.

Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3

Function: Significant glutathione conjugating activity is found only with the model substrate,

1-chloro-2,4-dinitrobenzene (CDNB)

summary for GSTK1:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTK1 gene promoter:
ISGF-3 RFX1 p300 AP-4 E47 PPAR-gamma1 Hand1 STAT3 Cart-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GSTK1 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34

GSTK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTK1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P142942: view genomic region (about GC identifiers)

Start:	142,941,186 bp from pter	End:	142,967,947 bp from pter
Size:	26,762 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 142,362,642-142,368,342

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3 (See protein sequence)

Recommended Name: Glutathione S-transferase kappa 1

Size: 226 amino acids; 25497 Da

Subunit: Homodimer

Subcellular location: Peroxisome

3 PDB 3D structures from and Proteopedia for GSTK1:

1YZX (3D)

3RPN (3D)

3RPP (3D)

Secondary accessions: B4DIH1 B4DSY2 Q6P4H0 Q7Z520 Q9P1S4

Alternative splicing: 4 isoforms: Q9Y2Q3-1 Q9Y2Q3-2 Q9Y2Q3-3 Q9Y2Q3-4

Explore the universe of human proteins at neXtProt for GSTK1: NX_Q9Y2Q3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y2Q3

GSTK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001137151.1 NP_001137152.1 NP_001137153.1 NP_057001.1

ENSEMBL proteins:

ENSP00000408341 ENSP00000386944 ENSP00000415813 ENSP00000351181 ENSP00000406802

ENSP00000431049

Human Recombinant Protein Products:

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	Novus Biologicals GSTK1 Proteins Novus Biologicals GSTK1 Lysates
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	ProSpec Recombinant Protein for GSTK1
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005759	mitochondrial matrix	IEA	--
GO:0005777	peroxisome	IDA	14742434

GSTK1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTK1 for domains About GeneDecksing

3 InterPro domains/families:

IPR012336 Thioredoxin-like_fold

IPR001853 DSBA-like_thioredoxin_dom

IPR014440 HCCAis_GSTk

Graphical View of Domain Structure for InterPro Entry Q9Y2Q3

ProtoNet protein and cluster: Q9Y2Q3

1 Blocks protein family: IPB001853 DSBA oxidoreductase

UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3

Similarity: Belongs to the GST superfamily. Kappa family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3

Function: Significant glutathione conjugating activity is found only with the model substrate,

1-chloro-2,4-dinitrobenzene (CDNB)

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Enzyme Number (IUBMB): EC 2.5.1.18¹

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		3 QIAGEN miScript miRNA Assays for microRNAs that regulate GSTK1:
		hsa-miR-4316 hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: GSTK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTK1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GSTK1

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		Search LifeMap BioReagents cell lines for GSTK1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTK1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IDA	14742434
GO:0004602	glutathione peroxidase activity	IDA	14742434
GO:0005102	receptor binding	IPI	--
GO:0015035	protein disulfide oxidoreductase activity	IEA	--

GSTK1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Gstk1^tm1Pgb for GSTK1
     8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gstk1):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	renal/urinary system	reproductive system

GSTK1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

	Glutathione metabolism	1.00			Glutathione metabolism	0.70
	Glutathione metabolism	0.92			glutathione-mediated detoxification I	0.53

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Peroxisome

Peroxisome

1.00

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GSTK1

Glutathione metabolism

1 GeneGo (Thomson Reuters) Pathway for GSTK1

Glutathione metabolism

2 BioSystems Pathways for GSTK1

	glutathione-mediated detoxification I
	metapathway biotransformation

4 Kegg Pathways (Kegg details for GSTK1):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450
	Peroxisome

GSTK1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GSTK1

5/96 Interacting proteins for GSTK1 (Q9Y2Q3^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 96)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCI	Q9NVI1³	I2D: score=3
ATXN10	Q9UBB4³	I2D: score=2
CYCS	P99999³	I2D: score=2
DCTN1	Q14203³	I2D: score=2
DDOST	P39656³	I2D: score=2

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006749	glutathione metabolic process	IEA	--

GSTK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for GSTK1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTK1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

9 HMDB Compounds for GSTK1 About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

2 DrugBank Compounds for GSTK1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17139284 17016423 14709161 10592235
GLUTATHIONE SULFINATE	--	--	target	--	--

Search CenterWatch for drugs/clinical trials and news about GSTK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTK1 gene (4 alternative transcripts):

NM_001143679.1 NM_001143680.1 NM_001143681.1 NM_015917.2

Unigene Cluster for GSTK1:

Glutathione S-transferase kappa 1

Hs.390667 [show with all ESTs]

Unigene Representative Sequence: AK299968

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000436038 ENST00000409500 ENST00000443571 ENST00000358406(uc003wci.3 uc011ksy.2 uc011ksz.2)

ENST00000442394 ENST00000479303(uc003wcj.3) ENST00000494735 ENST00000473649

ENST00000489654

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		3 QIAGEN miScript miRNA Assays for microRNAs that regulate GSTK1:
		hsa-miR-4316 hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: GSTK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTK1

Additional cDNA sequence:

AF068287.1 AF070657.1 AF087849.1 AK000640.1 AK289570.1 AK289580.1 AK295592.1 AK299968.1

AL136938.1 AY520571.1 BC001231.1 BC050715.1 BC063425.1 BC110600.1 CR533445.1

24/29 DOTS entries (see all 29):

DT.92447157 DT.95139185 DT.452861 DT.121119599 DT.100883917 DT.92447160 DT.95126889 DT.100883911

DT.100037551 DT.121119488 DT.100883919 DT.100806618 DT.100883920 DT.121119562 DT.100037549 DT.100883915

DT.100715288 DT.100883918 DT.102831454 DT.121119540 DT.408437 DT.92447153 DT.95090452 DT.121119502

24/558 AceView cDNA sequences (see all 558):

BI861198 AA489524 AI973186 BU070749 AI572553 BI908456 BM973654 BG696360

BF984756 AA293237 BU615212 AA568683 AA252793 AW150652 AA296946 CB130023

R55399 AA617704 CB112011 CB164146 BQ681153 AA478402 BQ428119 AA598673

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GSTK1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:											-												-
SP2:											-												-
SP3:											-								-				-
SP4:											-
SP5:

ECgene alternative splicing isoforms for GSTK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCAACCTT

About this image
See GSTK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTK1

SOURCE GeneReport for Unigene cluster: Hs.390667

UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including GSTK1:

Nephrotoxicity in human mouse rat

Oxidative Stress in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTK1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GSTK1 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gstk1^{1 , 5}	glutathione S-transferase kappa 1^{1, 5}	77.88(n)¹ 71.24(a)¹		6 (20.52 cM)⁵ 76263¹ NM_029555.2¹ NP_083831.1¹ 42245935⁵
chicken (Gallus gallus)	Aves	GSTK1¹	glutathione S-transferase kappa 1	61.95(n) 55.71(a)		418302 NM_001198649.1 NP_001185578.1
lizard (Anolis carolinensis)	Reptilia	GSTK1⁶	--	60(a)	1 ↔ 1	GL343381.1(164691-177904)
zebrafish (Danio rerio)	Actinopterygii	zgc:92763¹	zgc:92763	55.35(n) 50.23(a)		436833 NM_001002560.1 NP_001002560.1
worm (Caenorhabditis elegans)	Secernentea	gstk-1¹	Protein GSTK-1	46.05(n) 34.3(a)		191563 NM_063681.1 NP_496082.1

ENSEMBL Gene Tree for GSTK1 (if available)
TreeFam Gene Tree for GSTK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117275038^1,2	F,	--	142958636(+)	`GCATGC/TTCTTC`	4	--	us2k¹		1		EA	120
rs144580911^1,2		--	142958662(+)	`ACCTCA/GTATCT`	4	--	us2k¹		0	--	--	--	--
rs181360711^1,2		--	142958781(+)	`AAAGTC/TAAATG`	4	--	us2k¹		0	--	--	--	--
rs139892879^1,2		--	142958844(+)	`CAATAC/TGACTC`	4	--	us2k¹		0	--	--	--	--
rs114390131^1,2	F,	--	142958896(+)	`CACCAA/CAATTA`	4	--	us2k¹		1		WA	118
rs145339753^1,2		--	142958907(+)	`TCTATA/GGTGAG`	4	--	us2k¹		0	--	--	--	--
rs78669493^1,2		--	142958913(+)	`GTGAGG/ACCTCT`	4	--	us2k¹		1		NA	120
rs185383070^1,2		--	142958914(+)	`TGAGGA/CCTCTC`	4	--	us2k¹		0	--	--	--	--
rs147703238^1,2		--	142958980(+)	`TCAAAC/TGTGTC`	4	--	us2k¹		0	--	--	--	--
rs190376590^1,2		--	142959020(+)	`TAACAC/TAAGAA`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GSTK1 (142941186 - 142967947 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GSTK1: --
Human Gene Mutation Database (HGMD): GSTK1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GSTK1 for disorders           About GeneDecksing

OMIM gene information: 602321    OMIM disorders: --

4 diseases for GSTK1:    About MalaCards

parkinson's disease infertility prostate cancer prostatitis

Human Genome Epidemiology (HuGE) Navigator: GSTK1 (4 documents)

Export disorders for GSTK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GSTK1 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with GSTK1)

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Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization. (PubMed id 14742434)^{1, 2, 3, 9} Morel F....Guillouzo A. (2004)
Modelling and bioinformatics studies of the human kappa class glutathione transferase predict a novel third glutathione transferase family with homology to prokaryotic 2-hydroxychromene-2-carboxylate (HCCA) isomerases. (PubMed id 14709161)^{1, 2, 7, 9} Robinson A.... Board P.G. (2004)
Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme. (PubMed id 16081649)^{1, 2} Li J....Ding J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. (PubMed id 12720545)^{1, 3} Jowsey I.R....Hayes J.D. (2003)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
Analysis of the glutathione S-transferase (GST) gene family. (PubMed id 15607001)^{1, 9} Nebert D.W. and Vasiliou V. (2004)
MINOS1 is a conserved component of mitofilin complexe s and required for mitochondrial function and cristae organization. (PubMed id 22114354)¹ Alkhaja A.K....Deckers M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 373156	HGNC: 16906	AceView: GSTK1	Ensembl:ENSG00000197448	euGenes: HUgn373156
ECgene: GSTK1	Kegg: 373156	H-InvDB: GSTK1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GSTK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GSTK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GSTK1 gene:
Search GeneIP for patents involving GSTK1

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glutathione S-transferase kappa 1

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GSTK1 Gene

glutathione S-transferase kappa 1

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