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GSTK1 Gene

protein-coding   GIFtS: 62
GCID: GC07P142942

Glutathione S-Transferase Kappa 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Kappa 11 2     GST132
GSTK1-12 3     GST13-132
GST 13-132 3     Glutathione S-Transferase K12
GST Class-Kappa2 3     Glutathione S-Transferase Subunit 13 Homolog2
hGSTK12 3     EC 2.5.1.183
GST2     Glutathione S-Transferase Subunit 133

External Ids:    HGNC: 169061   Entrez Gene: 3731562   Ensembl: ENSG000001974487   OMIM: 6023215   UniProtKB: Q9Y2Q33   

Export aliases for GSTK1 gene to outside databases

Previous GC identifers: GC00U913601 GC07U901487 GC07P142477 GC07P142670 GC07P137297


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTK1 Gene:
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function
in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of
glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells.
Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jan 2009)

GeneCards Summary for GSTK1 Gene:
GSTK1 (glutathione S-transferase kappa 1) is a protein-coding gene. Diseases associated with GSTK1 include infertility, and parkinson's disease. GO annotations related to this gene include glutathione transferase activity and receptor binding.

UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3
Function: Significant glutathione conjugating activity is found only with the model substrate,
1-chloro-2,4-dinitrobenzene (CDNB)

Gene Wiki entry for GSTK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTK1 gene promoter:
         ISGF-3   RFX1   p300   AP-4   E47   PPAR-gamma1   Hand1   STAT3   Cart-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GSTK1 promoter sequence
   Search Chromatin IP Primers for GSTK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

GSTK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTK1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142942:  view genomic region     (about GC identifiers)

Start:
142,941,186 bp from pter      End:
142,967,947 bp from pter
Size:
26,762 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,362,642-142,368,342     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3 (See protein sequence)
Recommended Name: Glutathione S-transferase kappa 1  
Size: 226 amino acids; 25497 Da
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for GSTK1:
1YZX (3D)        3RPN (3D)        3RPP (3D)    
Secondary accessions: B4DIH1 B4DSY2 Q6P4H0 Q7Z520 Q9P1S4
Alternative splicing: 4 isoforms:  Q9Y2Q3-1   Q9Y2Q3-2   Q9Y2Q3-3   Q9Y2Q3-4   

Explore the universe of human proteins at neXtProt for GSTK1: NX_Q9Y2Q3

Explore proteomics data for GSTK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys71
  • Modification sites at PhosphoSitePlus

  • See GSTK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137151.1  NP_001137152.1  NP_001137153.1  NP_057001.1  

    ENSEMBL proteins: 
     ENSP00000408341   ENSP00000386944   ENSP00000415813   ENSP00000351181   ENSP00000406802  
     ENSP00000431049  

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    GSTK1 Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GSTK: Glutathione S-transferases / Mitochondrial (kappa)

    3 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR001853 DSBA-like_thioredoxin_dom
     IPR014440 HCCAis_GSTk

    Graphical View of Domain Structure for InterPro Entry Q9Y2Q3

    ProtoNet protein and cluster: Q9Y2Q3

    1 Blocks protein domain: IPB001853 DSBA oxidoreductase

    UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3
    Similarity: Belongs to the GST superfamily. Kappa family


    GSTK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTK1_HUMAN, Q9Y2Q3
    Function: Significant glutathione conjugating activity is found only with the model substrate,
    1-chloro-2,4-dinitrobenzene (CDNB)
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Enzyme Number (IUBMB): EC 2.5.1.181

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA14742434
    GO:0004602glutathione peroxidase activity IDA14742434
    GO:0005102receptor binding IPI--
    GO:0015035protein disulfide oxidoreductase activity IEA--
         
    GSTK1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gstk1):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  reproductive system 

    GSTK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gstk1tm1Pgb for GSTK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTK1

    miRNA
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    miRTarBase miRNAs that target GSTK1:
    hsa-mir-196a-5p (MIRT048157), hsa-mir-124-3p (MIRT022421)

    Block miRNA regulation of human, mouse, rat GSTK1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GSTK1:
    hsa-miR-4316 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidGSTK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GSTK1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): GSTK1 (NM_001143680)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTK1_HUMAN, Q9Y2Q3: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix IEA--
    GO:0005777peroxisome IDA14742434

    GSTK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione metabolism0.65
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    3Biological oxidations
    metapathway biotransformation0.42
    4Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GSTK1
        Glutathione metabolism

    2 BioSystems Pathways for GSTK1
        glutathione-mediated detoxification I
    metapathway biotransformation



    5 Kegg Pathways  (Kegg details for GSTK1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Peroxisome
    Chemical carcinogenesis


    GSTK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTK1: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GSTK1

    Selected Interacting proteins for GSTK1 (Q9Y2Q32, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCIQ9NVI13I2D: score=3 
    ATXN10Q9UBB43I2D: score=2 
    CCAR2Q8N1633I2D: score=2 
    CYCSP999993I2D: score=2 
    DCTN1Q142033I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IEA--
    GO:0030855epithelial cell differentiation IEP--
    GO:0055114oxidation-reduction process IDA14742434

    GSTK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTK1

    9 HMDB Compounds for GSTK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    2 DrugBank Compounds for GSTK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 17016423 14709161 10592235
    GLUTATHIONE SULFINATE-- --target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GSTK1 gene (4 alternative transcripts): 
    NM_001143679.1  NM_001143680.1  NM_001143681.1  NM_015917.2  

    Unigene Cluster for GSTK1:

    Glutathione S-transferase kappa 1
    Hs.390667  [show with all ESTs]
    Unigene Representative Sequence: AK299968
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436038 ENST00000409500 ENST00000443571 ENST00000358406(uc003wci.3 uc011ksy.2 uc011ksz.2)
    ENST00000442394 ENST00000479303(uc003wcj.3) ENST00000494735 ENST00000473649
    ENST00000489654

    miRNA
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    hsa-miR-4316 hsa-miR-124 hsa-miR-506
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF068287.1 AF070657.1 AF087849.1 AK000640.1 AK289570.1 AK289580.1 AK295592.1 AK299968.1 
    AL136938.1 AY520571.1 BC001231.1 BC050715.1 BC063425.1 BC110600.1 CR533445.1 

    Selected DOTS entries (see all 29):

    DT.92447157  DT.95139185  DT.452861  DT.121119599  DT.100883917  DT.92447160  DT.95126889  DT.100883911 
    DT.100037551  DT.121119488  DT.100883919  DT.100806618  DT.100883920  DT.121119562  DT.100037549  DT.100883915 
    DT.100715288  DT.100883918  DT.102831454  DT.121119540  DT.408437  DT.92447153  DT.95090452  DT.121119502 

    Selected AceView cDNA sequences (see all 558):

    AY520571 AA046903 BM788856 AA297915 AA489524 CR615801 BM976957 BM973654 
    BF724139 W88583 AW271779 BI771043 CD513113 AI365595 CB145406 CD370580 
    BC050715 AK095263 BM762982 BC063425 AI341947 CB112011 AU279516 BC001231 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GSTK1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                -                                   -                           
    SP2:                                -                                   -                           
    SP3:                                -                       -           -                           
    SP4:                                -                                                               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for GSTK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAACCTT
    GSTK1 Expression
    About this image

    GSTK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390667

    UniProtKB/Swiss-Prot: GSTK1_HUMAN, Q9Y2Q3
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTK1: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat GSTK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gstk11 , 5 glutathione S-transferase kappa 11, 5 73.3(n)1
    64.16(a)1
      6 (20.52 cM)5
    762631  NM_029555.21  NP_083831.11 
     422459355 
    chicken
    (Gallus gallus)
    Aves GSTK11 glutathione S-transferase kappa 1 62.81(n)
    57.41(a)
      418302  NM_001198649.1  NP_001185578.1 
    lizard
    (Anolis carolinensis)
    Reptilia GSTK16
    glutathione S-transferase kappa 1
    54(a)
    1 ↔ 1
    GL343381.1(164188-185377)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gstk11 glutathione S-transferase kappa 1 61.99(n)
    59.81(a)
      496688  NM_001011244.1  NP_001011244.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gstk11 glutathione S-transferase kappa 1 56.54(n)
    51.87(a)
      436833  NM_001002560.1  NP_001002560.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gstk-11 gstk-1 46.57(n)
    34.45(a)
      191563  NM_063681.1  NP_496082.1 


    ENSEMBL Gene Tree for GSTK1 (if available)
    TreeFam Gene Tree for GSTK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTK1 gene
    1 SIMAP similar gene for GSTK1 using alignment to 4 protein entries:     GSTK1_HUMAN (see all proteins):
    LOC51064

    GSTK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTK1 (see all 188)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172750381,2
    F--142958636(+) GCATGC/TTCTTC 4 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1445809111,2
    C--142958662(+) ACCTCA/GTATCT 4 -- us2k10--------
    rs1813607111,2
    --142958781(+) AAAGTC/TAAATG 4 -- us2k10--------
    rs1398928791,2
    C--142958844(+) CAATAC/TGACTC 4 -- us2k10--------
    rs1143901311,2
    C,F--142958896(+) CACCAA/CAATTA 4 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1453397531,2
    C--142958907(+) TCTATA/GGTGAG 4 -- us2k10--------
    rs786694931,2
    F--142958913(+) GTGAGG/ACCTCT 4 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1853830701,2
    --142958914(+) TGAGGA/CCTCTC 4 -- us2k10--------
    rs1477032381,2
    --142958980(+) TCAAAC/TGTGTC 4 -- us2k10--------
    rs1903765901,2
    --142959020(+) TAACAC/TAAGAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for GSTK1 (142941186 - 142967947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GSTK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735280CNV Deletion23290073
    nsv831169CNV Loss17160897

    Human Gene Mutation Database (HGMD): GSTK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTK1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602321    OMIM disorders: --

    5 diseases for GSTK1:    
    About MalaCards
    infertility    parkinson's disease    prostate cancer    prostatitis
    endotheliitis


    GSTK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): GSTK1
    Human Genome Epidemiology (HuGE) Navigator: GSTK1 (4 documents)

    Export disorders for GSTK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTK1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with GSTK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene and protein characterization of the human glutathione S- transferase kappa and evidence for a peroxisomal localization. (PubMed id 14742434)1, 2, 3, 9 Morel F....Guillouzo A. (J. Biol. Chem. 2004)
    2. Modelling and bioinformatics studies of the human kappa class glutathione transferase predict a novel third glutathione transferase family with homology to prokaryotic 2-hydroxychromene-2-carboxylate (HCCA) isomerases. (PubMed id 14709161)1, 2, 7, 9 Robinson A.... Board P.G. (Biochem. J. 2004)
    3. Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. (PubMed id 19225211)1, 4 Gao F....Xiang K. (Endocr. J. 2009)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    5. Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme. (PubMed id 16081649)1, 2 Li J.... Ding J. (Protein Sci. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. (PubMed id 12720545)1, 3 Jowsey I.R....Hayes J.D. (Biochem. J. 2003)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    10. Analysis of the glutathione S-transferase (GST) gene family. (PubMed id 15607001)1, 9 Nebert D.W. and Vasiliou V. (Hum. Genomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 373156 HGNC: 16906 AceView: GSTK1 Ensembl:ENSG00000197448 euGenes: HUgn373156
    ECgene: GSTK1 Kegg: 373156 H-InvDB: GSTK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GSTK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTK1 gene:
    Search GeneIP for patents involving GSTK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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