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Aliases for GSTCD Gene

Aliases for GSTCD Gene

  • Glutathione S-Transferase C-Terminal Domain Containing 2 3 5

External Ids for GSTCD Gene

Previous GeneCards Identifiers for GSTCD Gene

  • GC04P106849
  • GC04P106629
  • GC04P102364

Summaries for GSTCD Gene

GeneCards Summary for GSTCD Gene

GSTCD (Glutathione S-Transferase C-Terminal Domain Containing) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include methyltransferase activity and rRNA methyltransferase activity.

Additional gene information for GSTCD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTCD Gene

Genomics for GSTCD Gene

Regulatory Elements for GSTCD Gene

Enhancers for GSTCD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H105707 1.2 ENCODE 45.3 +0.5 464 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC LOC101929577 GSTCD TBCK INTS12 AIMP1 LINC02173 EEF1A1P9 LOC101929529 TET2
GH04H105637 0.9 Ensembl dbSUPER 34.2 -71.1 -71078 0 ZNF132 NFIB HLF ZNF195 FEZF1 YY1 LCORL NFIC ZNF350 ZNF300 GSTCD LOC101929577 TBCK LOC105377352 ARHGEF38 AIMP1 ENSG00000248778 ARHGEF38-IT1
GH04H105683 0.6 ENCODE 11.2 -25.6 -25560 0 SMARCE1 NFIB DPF2 FOXA1 ZNF217 CTBP1 GATA3 RCOR1 CUX1 INTS12 GSTCD ENSG00000248778
GH04H105612 0.6 dbSUPER 10 -95.1 -95069 1 ZNF217 SMARCE1 CTBP1 GATA3 MNT FOXP2 DPF2 INTS12 ARHGEF38 LOC105377352 GSTCD ARHGEF38-IT1 ENSG00000248778
GH04H104965 1.1 Ensembl ENCODE 5 -741.8 -741780 2 PKNOX1 TBL1XR1 RB1 BATF ATF7 ETV6 RUNX3 IKZF2 CREM CBFB TET2 GSTCD ENSG00000248242 RNU6-351P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GSTCD on UCSC Golden Path with GeneCards custom track

Promoters for GSTCD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171473 -78 2201 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC

Genomic Location for GSTCD Gene

Chromosome:
4
Start:
105,708,778 bp from pter
End:
105,847,728 bp from pter
Size:
138,951 bases
Orientation:
Plus strand

Genomic View for GSTCD Gene

Genes around GSTCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTCD Gene

Proteins for GSTCD Gene

  • Protein details for GSTCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEC7-GSTCD_HUMAN
    Recommended name:
    Glutathione S-transferase C-terminal domain-containing protein
    Protein Accession:
    Q8NEC7
    Secondary Accessions:
    • A8K8J0
    • A8MVD3
    • H9KV97
    • Q9H8S3

    Protein attributes for GSTCD Gene

    Size:
    633 amino acids
    Molecular mass:
    71079 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14532.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BX648355; Type=Frameshift; Positions=474; Evidence={ECO:0000305};

    Alternative splice isoforms for GSTCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTCD Gene

Post-translational modifications for GSTCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GSTCD Gene

Domains & Families for GSTCD Gene

Gene Families for GSTCD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GSTCD Gene

Suggested Antigen Peptide Sequences for GSTCD Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEC7

UniProtKB/Swiss-Prot:

GSTCD_HUMAN :
  • Belongs to the GSTCD family.
Family:
  • Belongs to the GSTCD family.
genes like me logo Genes that share domains with GSTCD: view

Function for GSTCD Gene

Phenotypes From GWAS Catalog for GSTCD Gene

Gene Ontology (GO) - Molecular Function for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with GSTCD: view
genes like me logo Genes that share phenotypes with GSTCD: view

Animal Models for GSTCD Gene

MGI Knock Outs for GSTCD:

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTCD

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GSTCD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTCD Gene

Localization for GSTCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTCD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTCD gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 24058608
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GSTCD: view

Pathways & Interactions for GSTCD Gene

genes like me logo Genes that share pathways with GSTCD: view

Pathways by source for GSTCD Gene

1 BioSystems pathway for GSTCD Gene

Gene Ontology (GO) - Biological Process for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GSTCD: view

No data available for SIGNOR curated interactions for GSTCD Gene

Drugs & Compounds for GSTCD Gene

No Compound Related Data Available

Transcripts for GSTCD Gene

Unigene Clusters for GSTCD Gene

Glutathione S-transferase, C-terminal domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GSTCD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GSTCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7: -
SP8: - -

Relevant External Links for GSTCD Gene

GeneLoc Exon Structure for
GSTCD
ECgene alternative splicing isoforms for
GSTCD

Expression for GSTCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTCD Gene

Protein differential expression in normal tissues from HIPED for GSTCD Gene

This gene is overexpressed in Liver (50.1) and Monocytes (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTCD Gene



Protein tissue co-expression partners for GSTCD Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTCD Gene:

GSTCD

SOURCE GeneReport for Unigene cluster for GSTCD Gene:

Hs.161429

mRNA Expression by UniProt/SwissProt for GSTCD Gene:

Q8NEC7-GSTCD_HUMAN
Tissue specificity: Widely expressed in cell types relevant to airway function, including airway smooth muscle cells and epithelial cells.
genes like me logo Genes that share expression patterns with GSTCD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTCD Gene

Orthologs for GSTCD Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTCD 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia GSTCD 33 34
  • 91.1 (n)
cow
(Bos Taurus)
Mammalia GSTCD 34 33
  • 88.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gstcd 33 16 34
  • 84.18 (n)
rat
(Rattus norvegicus)
Mammalia Gstcd 33
  • 79.83 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTCD 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSTCD 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSTCD 33 34
  • 70.97 (n)
lizard
(Anolis carolinensis)
Reptilia GSTCD 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstcd 33
  • 65.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14885 33
zebrafish
(Danio rerio)
Actinopterygii gstcd 33 34
  • 58.8 (n)
Dr.20454 33
fruit fly
(Drosophila melanogaster)
Insecta CG10428 34 33
  • 48.76 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008668 33
  • 46.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for GSTCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTCD Gene

ENSEMBL:
Gene Tree for GSTCD (if available)
TreeFam:
Gene Tree for GSTCD (if available)

Paralogs for GSTCD Gene

No data available for Paralogs for GSTCD Gene

Variants for GSTCD Gene

Sequence variations from dbSNP and Humsavar for GSTCD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000000969 -- 105,846,457(+) TAAAT(C/T)TCCTA utr-variant-3-prime
rs1000012156 -- 105,798,340(+) AACAC(A/T)CCTGT intron-variant
rs10000340 -- 105,842,521(+) AATGT(C/T)TTCTT intron-variant
rs1000049044 -- 105,847,270(+) GGATT(A/T)AAATA utr-variant-3-prime
rs1000059387 -- 105,746,079(+) TGACT(C/T)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTCD Gene

Variant ID Type Subtype PubMed ID
esv26261 CNV loss 19812545
esv2658421 CNV deletion 23128226
esv3306864 CNV mobile element insertion 20981092
esv3372040 CNV insertion 20981092
esv3372129 CNV insertion 20981092
esv3601669 CNV loss 21293372
nsv1000196 CNV loss 25217958
nsv1000947 CNV loss 25217958
nsv436449 CNV deletion 17901297
nsv441904 CNV loss 18776908
nsv514237 CNV loss 21397061
nsv526871 CNV gain 19592680

Variation tolerance for GSTCD Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTCD Gene

Disorders for GSTCD Gene

Relevant External Links for GSTCD

Genetic Association Database (GAD)
GSTCD
Human Genome Epidemiology (HuGE) Navigator
GSTCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTCD

No disorders were found for GSTCD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTCD Gene

Publications for GSTCD Gene

  1. GSTCD and INTS12 regulation and expression in the human lung. (PMID: 24058608) Obeidat M … Hall IP (PloS one 2013) 3 4 60
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 45 60
  3. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PMID: 20010835) Hancock DB … London SJ (Nature genetics 2010) 3 45 60
  4. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E … Tobin MD (Nature genetics 2010) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for GSTCD Gene

Sources for GSTCD Gene

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