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Aliases for GSTCD Gene

Aliases for GSTCD Gene

  • Glutathione S-Transferase C-Terminal Domain Containing 2 3
  • Glutathione S-Transferase, C-Terminal Domain Containing 2 5

External Ids for GSTCD Gene

Previous GeneCards Identifiers for GSTCD Gene

  • GC04P106849
  • GC04P106629
  • GC04P102364

Summaries for GSTCD Gene

GeneCards Summary for GSTCD Gene

GSTCD (Glutathione S-Transferase C-Terminal Domain Containing) is a Protein Coding gene. Among its related pathways are Phase II conjugation. GO annotations related to this gene include methyltransferase activity and rRNA methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTCD Gene

Genomics for GSTCD Gene

Regulatory Elements for GSTCD Gene

Promoters for GSTCD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSTCD on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTCD Gene

Chromosome:
4
Start:
105,708,778 bp from pter
End:
105,847,728 bp from pter
Size:
138,951 bases
Orientation:
Plus strand

Genomic View for GSTCD Gene

Genes around GSTCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTCD Gene

Proteins for GSTCD Gene

  • Protein details for GSTCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEC7-GSTCD_HUMAN
    Recommended name:
    Glutathione S-transferase C-terminal domain-containing protein
    Protein Accession:
    Q8NEC7
    Secondary Accessions:
    • A8K8J0
    • A8MVD3
    • H9KV97
    • Q9H8S3

    Protein attributes for GSTCD Gene

    Size:
    633 amino acids
    Molecular mass:
    71079 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14532.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BX648355; Type=Frameshift; Positions=474; Evidence={ECO:0000305};

    Alternative splice isoforms for GSTCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTCD Gene

Proteomics data for GSTCD Gene at MOPED

Post-translational modifications for GSTCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GSTCD Gene

Domains & Families for GSTCD Gene

Protein Domains for GSTCD Gene

Suggested Antigen Peptide Sequences for GSTCD Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEC7

UniProtKB/Swiss-Prot:

GSTCD_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GSTCD family.
Domain:
  • Contains 1 GST C-terminal domain.
Family:
  • Belongs to the GSTCD family.
genes like me logo Genes that share domains with GSTCD: view

No data available for Gene Families for GSTCD Gene

Function for GSTCD Gene

Gene Ontology (GO) - Molecular Function for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GSTCD: view
genes like me logo Genes that share phenotypes with GSTCD: view

Animal Models for GSTCD Gene

MGI Knock Outs for GSTCD:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTCD Gene

Localization for GSTCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTCD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTCD Gene COMPARTMENTS Subcellular localization image for GSTCD gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24058608
genes like me logo Genes that share ontologies with GSTCD: view

Pathways & Interactions for GSTCD Gene

SuperPathways for GSTCD Gene

Superpath Contained pathways
1 Phase II conjugation
genes like me logo Genes that share pathways with GSTCD: view

Pathways by source for GSTCD Gene

1 BioSystems pathway for GSTCD Gene

Interacting Proteins for GSTCD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353695%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000353695 Q8NEC7-GSTCD_HUMAN for GSTCD Gene via STRING I2D UniProtKB

Gene Ontology (GO) - Biological Process for GSTCD Gene

None

No data available for SIGNOR curated interactions for GSTCD Gene

Drugs & Compounds for GSTCD Gene

No Compound Related Data Available

Transcripts for GSTCD Gene

Unigene Clusters for GSTCD Gene

Glutathione S-transferase, C-terminal domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7: -
SP8: - -

Relevant External Links for GSTCD Gene

GeneLoc Exon Structure for
GSTCD
ECgene alternative splicing isoforms for
GSTCD

Expression for GSTCD Gene

mRNA expression in normal human tissues for GSTCD Gene

Protein differential expression in normal tissues from HIPED for GSTCD Gene

This gene is overexpressed in Liver (50.1) and Monocytes (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GSTCD Gene



SOURCE GeneReport for Unigene cluster for GSTCD Gene Hs.161429

mRNA Expression by UniProt/SwissProt for GSTCD Gene

Q8NEC7-GSTCD_HUMAN
Tissue specificity: Widely expressed in cell types relevant to airway function, including airway smooth muscle cells and epithelial cells.
genes like me logo Genes that share expression patterns with GSTCD: view

Protein tissue co-expression partners for GSTCD Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GSTCD Gene

Orthologs for GSTCD Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTCD 36
  • 100 (a)
OneToOne
GSTCD 35
  • 99.58 (n)
  • 99.53 (a)
cow
(Bos Taurus)
Mammalia GSTCD 35
  • 88.43 (n)
  • 87.16 (a)
GSTCD 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSTCD 36
  • 91 (a)
OneToOne
GSTCD 35
  • 91.1 (n)
  • 91.41 (a)
mouse
(Mus musculus)
Mammalia Gstcd 16
Gstcd 36
  • 84 (a)
OneToOne
Gstcd 35
  • 84.18 (n)
  • 84.49 (a)
oppossum
(Monodelphis domestica)
Mammalia GSTCD 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSTCD 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gstcd 35
  • 79.83 (n)
  • 77.82 (a)
chicken
(Gallus gallus)
Aves GSTCD 35
  • 70.97 (n)
  • 70.65 (a)
GSTCD 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSTCD 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14885 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gstcd 35
  • 65.2 (n)
  • 65.69 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.20454 35
gstcd 35
  • 58.8 (n)
  • 58.64 (a)
gstcd 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008668 35
  • 46.74 (n)
  • 38.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10428 35
  • 48.76 (n)
  • 40.15 (a)
CG10428 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for GSTCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTCD Gene

ENSEMBL:
Gene Tree for GSTCD (if available)
TreeFam:
Gene Tree for GSTCD (if available)

Paralogs for GSTCD Gene

No data available for Paralogs for GSTCD Gene

Variants for GSTCD Gene

Sequence variations from dbSNP and Humsavar for GSTCD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1294667 -- 105,733,816(-) ccagc(C/G/T)actgc intron-variant
rs1294668 -- 105,733,205(-) caagc(A/G)aacca intron-variant
rs1294671 -- 105,735,994(-) ACAAT(C/T)GGAGA intron-variant
rs1294672 -- 105,735,177(-) cagca(C/G)agagt intron-variant
rs1294673 -- 105,735,066(-) aacac(A/G)gccgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTCD Gene

Variant ID Type Subtype PubMed ID
nsv879699 CNV Gain 21882294
esv272461 CNV Insertion 20981092
esv271140 CNV Insertion 20981092
nsv879700 CNV Loss 21882294
nsv436449 CNV Deletion 17901297
esv2658421 CNV Deletion 23128226
esv26261 CNV Loss 19812545
nsv441904 CNV CNV 18776908
nsv514237 CNV Loss 21397061
nsv526871 CNV Gain 19592680

Variation tolerance for GSTCD Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTCD Gene

HapMap Linkage Disequilibrium report
GSTCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTCD Gene

Disorders for GSTCD Gene

Relevant External Links for GSTCD

Genetic Association Database (GAD)
GSTCD
Human Genome Epidemiology (HuGE) Navigator
GSTCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTCD

No disorders were found for GSTCD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTCD Gene

Publications for GSTCD Gene

  1. GSTCD and INTS12 regulation and expression in the human lung. (PMID: 24058608) Obeidat M. … Hall I.P. (PLoS ONE 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study. (PMID: 24915237) Levinsson A. … Nyberg F. (PLoS ONE 2014) 3

Products for GSTCD Gene

Sources for GSTCD Gene

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