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GSTA5 Gene

protein-coding   GIFtS: 50
GCID: GC06M052696

Glutathione S-Transferase Alpha 5

(Previous name: glutathione S-transferase A5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Alpha 51 2
Glutathione S-Transferase A51 2
Glutathione S-Transferase A5-52 3
GST Class-Alpha Member 52 3
EC 2.5.1.183 8
Glutathione Transferase A52

External Ids:    HGNC: 196621   Entrez Gene: 2213572   Ensembl: ENSG000001827937   OMIM: 6076055   UniProtKB: Q7RTV23   

Export aliases for GSTA5 gene to outside databases

Previous GC identifers: GC06M052652 GC06M052697 GC06M052743 GC06M052804 GC06M052527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTA5 Gene:
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety
of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large
superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM
138359).(supplied by OMIM, Sep 2008)

GeneCards Summary for GSTA5 Gene:
GSTA5 (glutathione S-transferase alpha 5) is a protein-coding gene. Diseases associated with GSTA5 include infertility, and hepatitis b. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTA5 gene promoter:
         GATA-3   CUTL1   AP-4   HNF-4alpha1   HNF-1A   YY1   Evi-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTA5 promoter sequence
   Search Chromatin IP Primers for GSTA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.2   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052696:  view genomic region     (about GC identifiers)

Start:
52,696,453 bp from pter      End:
52,710,893 bp from pter
Size:
14,441 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2 (See protein sequence)
Recommended Name: Glutathione S-transferase A5  
Size: 222 amino acids; 25722 Da
Subunit: Homodimer (By similarity)
Secondary accessions: Q5SZC2

Explore the universe of human proteins at neXtProt for GSTA5: NX_Q7RTV2

Explore proteomics data for GSTA5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTA5 (Q7RTV2) (see all 10)
     RYFPAFE  IDMYTEG  LVGNKLS  KYNLYGKD 


    See GSTA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_714543.1  
    ENSEMBL proteins: 
     ENSP00000360028   ENSP00000284562  
    Reactome Protein details: Q7RTV2

    GSTA5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for GSTA5
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    GenScript Custom Purified and Recombinant Proteins Services for GSTA5
    Novus Biologicals GSTA5 Protein
    Novus Biologicals GSTA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    GSTA5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GSTA5
    Novus Biologicals GSTA5 Antibodies
    Abcam antibodies for GSTA5
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for GSTA5
    Search LSBio for Antibodies for GSTA5

    GSTA5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GSTA5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q7RTV2

    ProtoNet protein and cluster: Q7RTV2

    2 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTA5_HUMAN, Q7RTV2
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity ISS--
    GO:0005515protein binding ----
         
    GSTA5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTA5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GSTA5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GSTA5
    SwitchGear 3'UTR luciferase reporter plasmidGSTA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTA5
    Predesigned siRNA for gene silencing in human, mouse, rat GSTA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTA5

    Clone
    Products:
         
    OriGene clones in human, mouse for GSTA5 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTA5 (NM_153699)
    Sino Biological Human cDNA Clone for GSTA5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GSTA5
    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTA5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTA5_HUMAN, Q7RTV2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    GSTA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione conjugation0.60
    4-hydroxy-2-nonenal detoxification0.00
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    52 Naphthylamine and 2 Nitronaphtalene metabolism
    2 Naphthylamine and 2 Nitronaphtalene metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for GSTA5
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism

    4 BioSystems Pathways for GSTA5
        glutathione-mediated detoxification I
    Glutathione metabolism
    metapathway biotransformation
    4-hydroxy-2-nonenal detoxification


    1 Reactome Pathway for GSTA5
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for GSTA5):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTA5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTA5: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GSTA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTA5 (ENSP000002845624) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH6ENSP000003783594STRING: ENSP00000378359
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process ISS--

    GSTA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTA5

    Selected HMDB Compounds for GSTA5 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for GSTA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 17016423 9331086 10085232 12076520



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GSTA5 gene: 
    NM_153699.1  

    Unigene Cluster for GSTA5:

    Glutathione S-transferase alpha 5
    Hs.646984
    Unigene Representative Sequence: NM_153699
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370989 ENST00000475052 ENST00000284562(uc003pba.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GSTA5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GSTA5
    SwitchGear 3'UTR luciferase reporter plasmidGSTA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSTA5
    Predesigned siRNA for gene silencing in human, mouse, rat GSTA5
    Clone
    Products:
         
    OriGene clones in human, mouse for GSTA5 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTA5 (NM_153699)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA5
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GSTA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTA5
      QuantiTect SYBR Green Assays in human, mouse, rat GSTA5
      QuantiFast Probe-based Assays in human, mouse, rat GSTA5

    1 DOTS entry:

    DT.91702252 

    Selected AceView cDNA sequences (see all 152):

    BU949701 CB163833 H69204 AV703708 AV653390 AV702143 AV652178 AI261839 
    AA846513 CR601508 BV204442 BG572303 BV204436 BV204430 BC002895 BI762502 
    BU949992 NM_000846 AV681629 CA773246 AV656284 BU685387 BV204535 CB145964 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GSTA5 Expression
    About this image


    GSTA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Thymus (Hematopoietic System)
             Thymus
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Neural Tube (Nervous System)
             Telencephalon
    GSTA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646984

    UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Tissue specificity: Expression not detected

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTA5: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSTA5
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSTA5
    QuantiTect SYBR Green Assays in human, mouse, rat GSTA5
    QuantiFast Probe-based Assays in human, mouse, rat GSTA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTA5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm37765
    Gsta21
    predicted gene 37765
    glutathione S-transferase, alpha 2 (Yc2)1
    81.38(n)1
    75.23(a)1
      9 (43.65 cM)5
    148581  NM_008182.31  NP_032208.21 
     782571295 
    chicken
    (Gallus gallus)
    Aves GSTA36
    --
    --
    63(a)
    61(a)
    many ↔ many
    many ↔ many
    3(87798977-87804665)
    3(87804937-87828658)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Glutathione S-transferase
    (see all 4)
    65(a)
    65(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(148460397-148466448)
    1(151792312-151798015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110282 Transcribed sequence with weak similarity to protein more 72.18(n)    137727877 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739616
    gstal6
    (see all 3)
    glutathione S-transferase, alpha-like
    (see all 3)
    52(a)
    52(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    13(701311-704057) ENSDARG00000039832
    13(715869-724232) ENSDARG00000090228
    worm
    (Caenorhabditis elegans)
    Secernentea gst-416
    F56A4.46
    (see all 5)
    Protein F56A4.4 (F56A4.4) mRNA, complete cds
    (see all 5)
    28(a)
    27(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    V(7398465-7399302) WBGene00001789
    V(2447895-2449243) WBGene00018912


    ENSEMBL Gene Tree for GSTA5 (if available)
    TreeFam Gene Tree for GSTA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTA5 gene
    GSTA22  GSTA42  HPGDS2  GSTA32  GSTA12  
    5 SIMAP similar genes for GSTA5 using alignment to 1 protein entry:     GSTA5_HUMAN:
    GSTA1    GSTA2    GSTA3    GSTalpha locus    GSTA4

    GSTA5 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for GSTA5
    PGOHUM00000240470 PGOHUM00000243193 PGOHUM00000243199


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTA5 (see all 466)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814408971,2
    --52696095(+) TGGGTC/TTGTTT 1 -- ds50010--------
    rs1130038021,2
    F--52696149(+) CAGCAG/CACAGA 1 -- ds50012Minor allele frequency- C:0.50CSA 6
    rs1901335351,2
    --52696247(+) TTACCC/GAGGAT 1 -- ds50010--------
    rs1823056911,2
    --52696250(+) CCCAGA/GATGGT 1 -- ds50010--------
    rs1873122581,2
    --52696272(+) TGTGCA/GTACCT 1 -- ds50010--------
    rs1908979571,2
    --52696291(+) CAGAGC/TGCATT 1 -- ds50010--------
    rs1822347791,2
    C--52696319(+) ATAGAC/TTGTAT 1 -- ds50010--------
    rs790255261,2
    C--52696541(+) AGAGTC/TTATTA 1 -- ut310--------
    rs43319851,2
    H--52696575(+) ACTTAG/AGTAAA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 418
    rs1998938011,2
    --52696610(+) AATATC/TGGTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GSTA5 (52696453 - 52710893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GSTA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673977CNV Deletion23128226
    esv2732089CNV Deletion23290073
    esv2732085CNV Deletion23290073
    esv2436160CNV Deletion19546169
    esv2732088CNV Deletion23290073
    nsv470818CNV Loss18288195
    nsv462945CNV Loss19166990
    nsv885883CNV Gain21882294
    nsv482097CNV Gain20164927

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607605    OMIM disorders: --

    5 diseases for GSTA5:    
    About MalaCards
    infertility    hepatitis b    hepatitis    lung cancer
    endotheliitis


    GSTA5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GSTA5
    Human Genome Epidemiology (HuGE) Navigator: GSTA5 (6 documents)

    Export disorders for GSTA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTA5 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with GSTA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PubMed id 12042665)1, 2, 3 Morel F.... Guillouzo A. (Pharmacogenetics 2002)
    2. The human hGSTA5 gene encodes an enzymatically active protein. (PubMed id 19664689)1, 2 Singh S.P....Zimniak P. (Biochim. Biophys. Acta 2010)
    3. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (amp 2010)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221357 HGNC: 19662 AceView: GSTA2andGSTA3andGSTA5 Ensembl:ENSG00000182793 euGenes: HUgn221357
    ECgene: GSTA5 Kegg: 221357 H-InvDB: GSTA5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GSTA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GSTA5 gene:
    Search GeneIP for patents involving GSTA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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