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Aliases for GSTA5 Gene

Aliases for GSTA5 Gene

  • Glutathione S-Transferase Alpha 5 2 3
  • EC 2.5.1.18 4 63
  • Glutathione S-Transferase A5-5 4
  • Glutathione S-Transferase A5 2
  • GST Class-Alpha Member 5 4

External Ids for GSTA5 Gene

Previous GeneCards Identifiers for GSTA5 Gene

  • GC06M052652
  • GC06M052697
  • GC06M052743
  • GC06M052804
  • GC06M052696
  • GC06M052527

Summaries for GSTA5 Gene

Entrez Gene Summary for GSTA5 Gene

  • The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]

GeneCards Summary for GSTA5 Gene

GSTA5 (Glutathione S-Transferase Alpha 5) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA5 Gene

Genomics for GSTA5 Gene

Regulatory Elements for GSTA5 Gene

Genomic Location for GSTA5 Gene

Start:
52,831,655 bp from pter
End:
52,870,329 bp from pter
Size:
38,675 bases
Orientation:
Minus strand

Genomic View for GSTA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA5 Gene

Proteins for GSTA5 Gene

  • Protein details for GSTA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTV2-GSTA5_HUMAN
    Recommended name:
    Glutathione S-transferase A5
    Protein Accession:
    Q7RTV2
    Secondary Accessions:
    • Q5SZC2

    Protein attributes for GSTA5 Gene

    Size:
    222 amino acids
    Molecular mass:
    25722 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTA5 Gene

Proteomics data for GSTA5 Gene at MOPED

Post-translational modifications for GSTA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GSTA5 Gene

Gene Families for GSTA5 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

Suggested Antigen Peptide Sequences for GSTA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTV2

UniProtKB/Swiss-Prot:

GSTA5_HUMAN :
  • Q7RTV2
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA5: view

Function for GSTA5 Gene

Molecular function for GSTA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione.

Enzyme Numbers (IUBMB) for GSTA5 Gene

Gene Ontology (GO) - Molecular Function for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GSTA5: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GSTA5 Gene

Localization for GSTA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTA5 Gene COMPARTMENTS Subcellular localization image for GSTA5 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GSTA5: view

Pathways for GSTA5 Gene

genes like me logo Genes that share pathways with GSTA5: view

Interacting Proteins for GSTA5 Gene

Gene Ontology (GO) - Biological Process for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process ISS --
genes like me logo Genes that share ontologies with GSTA5: view

Compounds for GSTA5 Gene

(12) HMDB Compounds for GSTA5 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(1) Drugbank Compounds for GSTA5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target
genes like me logo Genes that share compounds with GSTA5: view

Transcripts for GSTA5 Gene

mRNA/cDNA for GSTA5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA5 Gene

No ASD Table

Relevant External Links for GSTA5 Gene

GeneLoc Exon Structure for
GSTA5
ECgene alternative splicing isoforms for
GSTA5

Expression for GSTA5 Gene

mRNA expression in normal human tissues for GSTA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA5 Gene

This gene is overexpressed in Testis (17.0), Adrenal Gland (7.5), Minor Salivary Gland (7.1), Liver (6.9), and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GSTA5 Gene

SOURCE GeneReport for Unigene cluster for GSTA5 Gene Hs.646984

mRNA Expression by UniProt/SwissProt for GSTA5 Gene

Q7RTV2-GSTA5_HUMAN
Tissue specificity: Expression not detected
genes like me logo Genes that share expressions with GSTA5: view

Orthologs for GSTA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTA5 35
  • 98.5 (n)
  • 96.4 (a)
GSTA5 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm3776 16
Gsta1 36
  • 74 (a)
ManyToMany
Gsta2 35
  • 81.38 (n)
  • 75.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gsta5 35
  • 80.63 (n)
  • 74.32 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 61 (a)
ManyToMany
GSTA3 36
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11028 35
zebrafish
(Danio rerio)
Actinopterygii gstal 36
  • 52 (a)
ManyToMany
zgc:173961 36
  • 52 (a)
ManyToMany
zgc:173962 36
  • 52 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F56A4.3 36
  • 27 (a)
ManyToMany
F56A4.4 36
  • 27 (a)
ManyToMany
gst-10 36
  • 27 (a)
ManyToMany
gst-41 36
  • 28 (a)
ManyToMany
Y45G12C.3 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for GSTA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTA5 Gene

ENSEMBL:
Gene Tree for GSTA5 (if available)
TreeFam:
Gene Tree for GSTA5 (if available)

Paralogs for GSTA5 Gene

Paralogs for GSTA5 Gene

Selected SIMAP similar genes for GSTA5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GSTA5 Gene

genes like me logo Genes that share paralogs with GSTA5: view

Variants for GSTA5 Gene

Sequence variations from dbSNP and Humsavar for GSTA5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2397117 -- 52,836,122(+) CATCC(C/T)CAAGA intron-variant
rs2397118 - 52,836,345(+) TGGTA(C/T)TTGCT missense, reference
rs2397119 -- 52,836,660(+) GCATG(C/T)GCCAA intron-variant
rs2397120 -- 52,836,759(+) CACCC(A/G)CCTCA intron-variant
rs2397121 -- 52,836,791(+) ACAGG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTA5 Gene

Variant ID Type Subtype PubMed ID
nsv462945 CNV Loss 19166990
nsv470818 CNV Loss 18288195
esv2732085 CNV Deletion 23290073
nsv885883 CNV Gain 21882294
esv2436160 CNV Deletion 19546169
esv2732088 CNV Deletion 23290073
esv2673977 CNV Deletion 23128226
nsv482097 CNV Gain 20164927
esv2732089 CNV Deletion 23290073

Relevant External Links for GSTA5 Gene

HapMap Linkage Disequilibrium report
GSTA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA5 Gene

Disorders for GSTA5 Gene

Relevant External Links for GSTA5

Genetic Association Database (GAD)
GSTA5
Human Genome Epidemiology (HuGE) Navigator
GSTA5
genes like me logo Genes that share disorders with GSTA5: view

No data available for UniProtKB/Swiss-Prot for GSTA5 Gene

Publications for GSTA5 Gene

  1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PMID: 12042665) Morel F. … Guillouzo A. (Pharmacogenetics 2002) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 48
  5. The human hGSTA5 gene encodes an enzymatically active protein. (PMID: 19664689) Singh S.P. … Zimniak P. (Biochim. Biophys. Acta 2010) 3 4

Products for GSTA5 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cellular Stress Responses in human,mouse,rat
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GSTA5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GSTA5
    • Block miRNA regulation of GSTA5 using miScript Target Protectors

    Sources for GSTA5 Gene

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