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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTA5 Gene

protein-coding   GIFtS: 51
GCID: GC06M052696

Glutathione S-Transferase Alpha 5

(Previous name: glutathione S-transferase A5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione S-Transferase Alpha 51 2
Glutathione S-Transferase A51 2
Glutathione S-Transferase A5-52 3
GST Class-Alpha Member 52 3
EC 2.5.1.183 8
Glutathione Transferase A52

External Ids:    HGNC: 196621   Entrez Gene: 2213572   Ensembl: ENSG000001827937   OMIM: 6076055   UniProtKB: Q7RTV23   

Export aliases for GSTA5 gene to outside databases

Previous GC identifers: GC06M052652 GC06M052697 GC06M052743 GC06M052804 GC06M052527


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTA5 Gene:
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety
of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large
superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM
138359).(supplied by OMIM, Sep 2008)

GeneCards Summary for GSTA5 Gene: 
GSTA5 (glutathione S-transferase alpha 5) is a protein-coding gene. Diseases associated with GSTA5 include cytochrome p450, and infertility, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTA5 gene promoter:
         GATA-3   CUTL1   AP-4   HNF-4alpha1   HNF-1A   YY1   Evi-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.2   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052696:  view genomic region     (about GC identifiers)

Start:
52,696,453 bp from pter      End:
52,710,986 bp from pter
Size:
14,534 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2 (See protein sequence)
Recommended Name: Glutathione S-transferase A5  
Size: 222 amino acids; 25722 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5SZC2

Explore the universe of human proteins at neXtProt for GSTA5: NX_Q7RTV2

Explore proteomics data for GSTA5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7RTV2

  • 4/10 DME Specific Peptides for GSTA5 (Q7RTV2) (see all 10)
     RYFPAFE  IDMYTEG  LVGNKLS  KYNLYGKD 

    GSTA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSTA5 Protein Expression
    REFSEQ proteins: NP_714543.1  
    ENSEMBL proteins: 
     ENSP00000360028   ENSP00000284562  
    Reactome Protein details: Q7RTV2
    Human Recombinant Protein Products for GSTA5: 
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    Novus Biologicals GSTA5 Protein
    Novus Biologicals GSTA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    GSTA5 for ontologies           About GeneDecksing



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    Assay Products for GSTA5: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    5/6 InterPro protein domains (see all 6):
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry Q7RTV2

    ProtoNet protein and cluster: Q7RTV2

    2 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTA5_HUMAN, Q7RTV2
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity ISS--
    GO:0005515protein binding ----
         
    GSTA5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSTA5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSTA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTA5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTA5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTA5
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of GSTA5 

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    Search LifeMap BioReagents cell lines for GSTA5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GSTA5 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione metabolism0.45
    Glutathione metabolism0.67
    glutathione-mediated detoxification I0.42
    Glutathione conjugation0.60
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    4Metabolism
    Metabolism0.40
    5Acetaminophen metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for GSTA5
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism


    2 GeneGo (Thomson Reuters) Pathways for GSTA5
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism

    4 BioSystems Pathways for GSTA5
        glutathione-mediated detoxification I
    Glutathione metabolism
    metapathway biotransformation
    4-hydroxy-2-nonenal detoxification

    4        Reactome Pathways for GSTA5
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation


    4         Kegg Pathways  (Kegg details for GSTA5):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTA5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSTA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for GSTA5 (ENSP000002845624) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process ISS--

    GSTA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for GSTA5:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSTA5

    10/12 HMDB Compounds for GSTA5 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for GSTA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 17016423 9331086 10085232 12076520

    Search CenterWatch for drugs/clinical trials and news about GSTA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSTA5 gene: 
    NM_153699.1  

    Unigene Cluster for GSTA5:

    Glutathione S-transferase alpha 5
    Hs.646984
    Unigene Representative Sequence: NM_153699
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475052 ENST00000370989 ENST00000284562(uc003pba.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGSTA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA5
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSTA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSTA5

    1 DOTS entry:

    DT.91702252 

    24/152 AceView cDNA sequences (see all 152):

    AV703708 AA846513 AV652178 AI261839 CB163833 H69204 AV702143 AV653390 
    CR601508 BU949701 AA876288 AV707807 AV704118 AV655685 BC002895 BE795593 
    AV701016 AV657115 CA773246 CB145964 BU570753 BV184052 AV707851 AV681629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTA5 expression in normal human tissues (normalized intensities)      GSTA5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GSTA5 Expression
    About this image


    GSTA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   

    See GSTA5 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.646984

    UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Tissue specificity: Expression not detected

        SABiosciences Expression via Pathway-Focused PCR Arrays including GSTA5: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GSTA5 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm37765
    Gsta21
    predicted gene 37765
    glutathione S-transferase, alpha 2 (Yc2)1
    81.38(n)1
    75.23(a)1
      9 (43.65 cM)5
    148581  NM_008182.31  NP_032208.21 
     782571295 
    chicken
    (Gallus gallus)
    Aves GSTA6
    GSTA36
    (see all 3)
    Glutathione S-transferase
    (see all 3)
    68(a)
    63(a)
    (see all 3)
    possible ortholog
    many ↔ many
    (see all 3)
    3(87829502-87837950)
    3(87798977-87804665)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Glutathione S-transferase
    (see all 4)
    65(a)
    65(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(151781701-151787309)
    1(151792312-151798015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110282 Transcribed sequence with weak similarity to protein more 72.18(n)    137727877 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739616
    zgc:1739626
    (see all 3)
    zgc:173962
    (see all 3)
    52(a)
    52(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    13(701311-704057)
    13(707116-712513)


    ENSEMBL Gene Tree for GSTA5 (if available)
    TreeFam Gene Tree for GSTA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTA5 gene
    GSTA22  GSTA42  HPGDS2  GSTA32  GSTA12  
    5 SIMAP similar genes for GSTA5 using alignment to 1 protein entry:     GSTA5_HUMAN:
    GSTA1    GSTA2    GSTalpha locus    GSTA3    GSTA4

    GSTA5 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for GSTA5
    PGOHUM00000240470 PGOHUM00000243193 PGOHUM00000243199


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in GSTA5 are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814408971,2
    --52696095(+) TGGGTC/TTGTTT 1 -- ds50010--------
    rs1130038021,2
    F--52696149(+) CAGCAG/CACAGA 1 -- ds50012Minor allele frequency- C:0.50CSA 6
    rs1901335351,2
    --52696247(+) TTACCC/GAGGAT 1 -- ds50010--------
    rs1823056911,2
    --52696250(+) CCCAGA/GATGGT 1 -- ds50010--------
    rs1873122581,2
    --52696272(+) TGTGCA/GTACCT 1 -- ds50010--------
    rs1908979571,2
    --52696291(+) CAGAGC/TGCATT 1 -- ds50010--------
    rs1822347791,2
    C--52696319(+) ATAGAC/TTGTAT 1 -- ds50010--------
    rs790255261,2
    C--52696541(+) AGAGTC/TTATTA 1 -- ut310--------
    rs43319851,2
    H--52696575(+) ACTTAG/AGTAAA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 418
    rs1998938011,2
    --52696610(+) AATATC/TGGTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GSTA5 (52696453 - 52710986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GSTA5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673977CNV Deletion23128226
    esv2732089CNV Deletion23290073
    esv2732085CNV Deletion23290073
    esv2436160CNV Deletion19546169
    esv2732088CNV Deletion23290073
    nsv470818CNV Loss18288195
    nsv462945CNV Loss19166990
    nsv885883CNV Gain21882294
    nsv482097CNV Gain20164927

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607605    OMIM disorders: --

    4 diseases for GSTA5:    About MalaCards
    cytochrome p450    infertility    hepatitis b    hepatitis


    GSTA5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GSTA5
    Human Genome Epidemiology (HuGE) Navigator: GSTA5 (6 documents)

    Export disorders for GSTA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTA5 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with GSTA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PubMed id 12042665)1, 2, 3 Morel F.... Guillouzo A. (2002)
    2. Glutathione pathway genetic polymorphisms and lung ca ncer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    8. The human hGSTA5 gene encodes an enzymatically active protein. (PubMed id 19664689)1 Singh S.P....Zimniak P. (2010)
    9. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221357 HGNC: 19662 AceView: GSTA2andGSTA3andGSTA5 Ensembl:ENSG00000182793 euGenes: HUgn221357
    ECgene: GSTA5 Kegg: 221357 H-InvDB: GSTA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSTA5 gene:
    Search GeneIP for patents involving GSTA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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