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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTA5 Gene

protein-coding   GIFtS: 51
GCID: GC06M052696

glutathione S-transferase alpha 5

(Previous name: glutathione S-transferase A5 )
 Explore 5 diseases affiliated with
GSTA5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GSTA5    

Aliases
for GSTA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutathione S-Transferase Alpha 51 2
Glutathione S-Transferase A51 2
Glutathione S-Transferase A5-52 3
GST Class-Alpha Member 52 3
EC 2.5.1.183 8
Glutathione Transferase A52

External Ids:    HGNC: 196621   Entrez Gene: 2213572   Ensembl: ENSG000001827937   OMIM: 6076055   UniProtKB: Q7RTV23   

Export aliases for GSTA5 gene to outside databases

Previous GC identifers: GC06M052652 GC06M052697 GC06M052743 GC06M052804 GC06M052527


Summaries
for GSTA5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GSTA5:
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of
electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with
members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).(supplied by
OMIM, Sep 2008)

summary for GSTA5:
Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both
eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,
xenobiotic substrates, thus aiding excretion from the body.




Genomic Views
for GSTA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTA5 gene promoter:
         GATA-3   CUTL1   AP-4   HNF-4alpha1   HNF-1A   YY1   Evi-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.2   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052696:  view genomic region     (about GC identifiers)

Start:
 52,696,453 bp from pter      End:
 52,710,986 bp from pter
Size:
 14,534 bases      Orientation:
 minus strand

Proteins
for GSTA5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2 (See protein sequence)
Recommended Name: Glutathione S-transferase A5  
Size: 222 amino acids; 25722 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5SZC2

Explore the universe of human proteins at neXtProt for GSTA5: NX_Q7RTV2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7RTV2

    • 4/10 DME Specific Peptides for GSTA5 (Q7RTV2) (see all 10)
     RYFPAFE  IDMYTEG  LVGNKLS  KYNLYGKD 

    GSTA5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_714543.1  
    ENSEMBL proteins: 
     ENSP00000360028   ENSP00000284562  
    Reactome Protein details: Q7RTV2
    Human Recombinant Protein Products: 
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    Novus Biologicals GSTA5 Protein
    Novus Biologicals GSTA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    GSTA5 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for GSTA5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GSTA5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry Q7RTV2

    ProtoNet protein and cluster: Q7RTV2

    2 Blocks protein families:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Function
    for GSTA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

    Enzyme Number (IUBMB): EC 2.5.1.181 2

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: GSTA5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSTA5
    OriGene shRNA RFP: GSTA5
    OriGene siRNA: GSTA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTA5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GSTA5

    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GSTA5
    Search LifeMap BioReagents cell lines for GSTA5

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GSTA5

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity ISS--


    GSTA5 for ontologies           About GeneDecksing



    Pathways & Interactions
    for GSTA5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glutathione metabolism
    		Glutathione metabolism1.00
    		glutathione-mediated detoxification I0.53
    		Glutathione metabolism0.92
    		Glutathione conjugation0.50
    		Glutathione metabolism0.70
    		Glutathione metabolism0.44
    2Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    32-Naphthylamine and 2-Nitronaphtalene metabolism
    		2-Naphthylamine and 2-Nitronaphtalene metabolism1.00
    		2-Naphthylamine and 2-Nitronaphtalene metabolism0.95
    4Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Metabolism of xenobiotics by cytochrome P4500.73
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for GSTA5
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism


    2 GeneGo (Thomson Reuters) Pathways for GSTA5
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism

    4 BioSystems Pathways for GSTA5 
        glutathione-mediated detoxification I
    metapathway biotransformation
    Glutathione metabolism
    4-hydroxy-2-nonenal detoxification

    4        Reactome Pathways for GSTA5
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation


    3         Kegg Pathways  (Kegg details for GSTA5):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450


    GSTA5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSTA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for GSTA5 (ENSP000002845624) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process ISS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--


    GSTA5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GSTA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for GSTA5:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GSTA5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ellagic acidSelective inhibitor of CK2. Also inhibits glutathione S-transferase[476-66-4]

    10/12 HMDB Compounds for GSTA5 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for GSTA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 17016423 9331086 10085232 12076520

    Search CenterWatch for drugs/clinical trials and news about GSTA5 

    Transcripts
    for GSTA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GSTA5 gene: 
    NM_153699.1  

    Unigene Cluster for GSTA5:

    Glutathione S-transferase alpha 5
    Hs.646984
    Unigene Representative Sequence: NM_153699
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475052 ENST00000370989 ENST00000284562(uc003pba.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSTA5
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    SwitchGear 3'UTR luciferase reporter plasmid: GSTA5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSTA5
    OriGene shRNA RFP: GSTA5
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSTA5
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GSTA5 (NM_153699)
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    Primer
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    1 DOTS entry:

    DT.91702252 

    24/152 AceView cDNA sequences (see all 152):

    AV703708 H69204 AA846513 AV702143 BU949701 AV652178 CR601508 AV653390 
    AI261839 CB163833 AV681855 AV703732 AF020919 BU949992 AV707851 BX283159 
    BX279891 R83404 BV204442 BV204472 T73486 BE795593 M16594 BV204430 

    GeneLoc Exon Structure


    Expression
    for GSTA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GSTA5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Embryoid bodies (Two-step protocol fo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GSTA5 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.646984

    UniProtKB/Swiss-Prot: GSTA5_HUMAN, Q7RTV2
    Tissue specificity: Expression not detected

        SABiosciences Expression via Pathway-Focused PCR Arrays including GSTA5: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GSTA5

    Orthologs
    for GSTA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GSTA5 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GSTA1_CHICK6
    		 Glutathione S-transferase
    		 63(a)
    		 1 → many
    		 3(91202951-91209673)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 65(a)
    65(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 1(151781701-151787309)
    1(151792312-151798015)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.110282 Transcribed sequence with weak similarity to protein more 72.18(n)    137727877 
    zebrafish
    (Danio rerio)    		 Actinopterygii gstal6
    zgc:1739616
    (see all 3)    		 zgc:173961
    (see all 3)    		 52(a)
    52(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 13(715869-724232)
    13(701311-704057)


    ENSEMBL Gene Tree for GSTA5 (if available)
    TreeFam Gene Tree for GSTA5 (if available) 

    Paralogs
    for GSTA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTA5 gene
    GSTA42  GSTA32  GSTA12  GSTM12  GSTM32  GSTA22  GSTP12  GSTM42  
    HPGDS2  GSTM52  GSTM22  
    5 SIMAP similar genes for GSTA5 using alignment to 1 protein entry:     GSTA5_HUMAN:
    GSTA1    GSTA2    GSTalpha locus    GSTA3    GSTA4

    GSTA5 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for GSTA5
    PGOHUM00000240470 PGOHUM00000243193 PGOHUM00000243199


    Genomic Variants
    for GSTA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 NCBI SNPs in GSTA5 are shown (see all 387)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1814408971,2
    		--52696095(+) TGGGTC/TTGTTT 1 -- ds50010--------
    rs1130038021,2
    		F,--52696149(+) CAGCAG/CACAGA 1 -- ds50012Minor allele frequency- C:0.50CSA 6
    rs1901335351,2
    		--52696247(+) TTACCC/GAGGAT 1 -- ds50010--------
    rs1823056911,2
    		--52696250(+) CCCAGA/GATGGT 1 -- ds50010--------
    rs1873122581,2
    		--52696272(+) TGTGCA/GTACCT 1 -- ds50010--------
    rs1908979571,2
    		--52696291(+) CAGAGC/TGCATT 1 -- ds50010--------
    rs1822347791,2
    		--52696319(+) ATAGAC/TTGTAT 1 -- ds50010--------
    rs790255261,2
    		C,--52696541(+) AGAGTC/TTATTA 1 -- ut310--------
    rs43319851,2
    		H--52696575(+) ACTTAG/AGTAAA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 418
    rs1998938011,2
    		--52696610(+) AATATC/TGGTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GSTA5 (52696453 - 52710986 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GSTA5
         1 CNV: 99540

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    Disorders / Diseases
    for GSTA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GSTA5 for disorders           About GeneDecksing

    OMIM gene information: 607605    OMIM disorders: --

    5 diseases for GSTA5:    About MalaCards
    hepatitis b    hermaphroditism    infertility    hepatitis
    malaria

    Human Genome Epidemiology (HuGE) Navigator: GSTA5 (6 documents)

    Export disorders for GSTA5 gene to outside databases

    Publications
    for GSTA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTA5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with GSTA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PubMed id 12042665)1, 2, 3 Morel F.... Guillouzo A. (2002)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    4. The human hGSTA5 gene encodes an enzymatically active protein. (PubMed id 19664689)1 Singh S.P....Zimniak P. (2010)
    5. Glutathione pathway genetic polymorphisms and lung ca ncer survival after platinum-based chemotherapy. (PubMed id 20200426)1 Moyer A.M....Weinshilboum R.M. (2010)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1 Starr J.M....Deary I.J. (2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1 Harris S.E....Deary I.J. (2007)
    8. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    10. Expression of rat liver glutathione-S-transferase GST A5 in cell lines provides increased resistance to alkylating agents and toxic a ldehydes. (PubMed id 12076520)7 Kazi S. and Ellis E.M. (2002)

    External Searches for GSTA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing GSTA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221357 HGNC: 19662 AceView: GSTA2andGSTA3andGSTA5 Ensembl:ENSG00000182793 euGenes: HUgn221357
    ECgene: GSTA5 Kegg: 221357 H-InvDB: GSTA5

    Other Databases showing GSTA5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GSTA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTA5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GSTA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GSTA5 gene:
    Search GeneIP for patents involving GSTA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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