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Aliases for GSTA5 Gene

Aliases for GSTA5 Gene

  • Glutathione S-Transferase Alpha 5 2 3 5
  • EC 4 63
  • Glutathione S-Transferase A5-5 4
  • Glutathione S-Transferase A5 2
  • GST Class-Alpha Member 5 4

External Ids for GSTA5 Gene

Previous GeneCards Identifiers for GSTA5 Gene

  • GC06M052652
  • GC06M052697
  • GC06M052743
  • GC06M052804
  • GC06M052696
  • GC06M052527

Summaries for GSTA5 Gene

Entrez Gene Summary for GSTA5 Gene

  • The glutathione S-transferases (GST; EC catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]

GeneCards Summary for GSTA5 Gene

GSTA5 (Glutathione S-Transferase Alpha 5) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Glutathione metabolism. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA5 Gene

Genomics for GSTA5 Gene

Regulatory Elements for GSTA5 Gene

Enhancers for GSTA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSTA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSTA5 Gene

52,831,655 bp from pter
52,870,329 bp from pter
38,675 bases
Minus strand

Genomic View for GSTA5 Gene

Genes around GSTA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA5 Gene

Proteins for GSTA5 Gene

  • Protein details for GSTA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione S-transferase A5
    Protein Accession:
    Secondary Accessions:
    • Q5SZC2

    Protein attributes for GSTA5 Gene

    222 amino acids
    Molecular mass:
    25722 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTA5 Gene

Proteomics data for GSTA5 Gene at MOPED

Post-translational modifications for GSTA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GSTA5 Gene

Gene Families for GSTA5 Gene

Suggested Antigen Peptide Sequences for GSTA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Alpha family.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA5: view

Function for GSTA5 Gene

Molecular function for GSTA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.

Enzyme Numbers (IUBMB) for GSTA5 Gene

Gene Ontology (GO) - Molecular Function for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with GSTA5: view

Phenotypes for GSTA5 Gene

genes like me logo Genes that share phenotypes with GSTA5: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTA5 Gene

Localization for GSTA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA5 Gene


Subcellular locations from

Jensen Localization Image for GSTA5 Gene COMPARTMENTS Subcellular localization image for GSTA5 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GSTA5: view

Pathways & Interactions for GSTA5 Gene

genes like me logo Genes that share pathways with GSTA5: view

Interacting Proteins for GSTA5 Gene

Gene Ontology (GO) - Biological Process for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GSTA5: view

No data available for SIGNOR curated interactions for GSTA5 Gene

Drugs & Compounds for GSTA5 Gene

(2) Drugs for GSTA5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Trichloroethylene Pharma 5

(40) Additional Compounds for GSTA5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTA5: view

Transcripts for GSTA5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA5 Gene

No ASD Table

Relevant External Links for GSTA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSTA5 Gene

mRNA expression in normal human tissues for GSTA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA5 Gene

This gene is overexpressed in Testis (x17.0), Adrenal Gland (x7.5), Minor Salivary Gland (x7.1), Liver (x6.9), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GSTA5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTA5 Gene

SOURCE GeneReport for Unigene cluster for GSTA5 Gene Hs.646984

mRNA Expression by UniProt/SwissProt for GSTA5 Gene

Tissue specificity: Expression not detected.
genes like me logo Genes that share expression patterns with GSTA5: view

Protein tissue co-expression partners for GSTA5 Gene

Primer Products

Orthologs for GSTA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gsta2 35
  • 81.38 (n)
  • 75.23 (a)
Gsta2 16
Gsta1 36
  • 74 (a)
(Pan troglodytes)
Mammalia GSTA5 35
  • 98.5 (n)
  • 96.4 (a)
GSTA5 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Gsta5 35
  • 80.63 (n)
  • 74.32 (a)
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
(Gallus gallus)
Aves -- 36
  • 61 (a)
GSTA3 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
-- 36
  • 65 (a)
-- 36
  • 65 (a)
-- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11028 35
(Danio rerio)
Actinopterygii gstal 36
  • 52 (a)
zgc:173961 36
  • 52 (a)
zgc:173962 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F56A4.3 36
  • 27 (a)
F56A4.4 36
  • 27 (a)
gst-10 36
  • 27 (a)
gst-41 36
  • 28 (a)
Y45G12C.3 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for GSTA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTA5 Gene

Gene Tree for GSTA5 (if available)
Gene Tree for GSTA5 (if available)

Paralogs for GSTA5 Gene

Paralogs for GSTA5 Gene

(5) SIMAP similar genes for GSTA5 Gene using alignment to 1 proteins: Pseudogenes for GSTA5 Gene

genes like me logo Genes that share paralogs with GSTA5: view

Variants for GSTA5 Gene

Sequence variations from dbSNP and Humsavar for GSTA5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2397118 - 52,836,345(+) TGGTA(C/T)TTGCT reference, missense
rs5876289 -- 52,842,406(+) TTTTT(-/T/TT/TTT/TTTT)GAGAT intron-variant
rs6458880 -- 52,833,855(+) GAGCC(C/T)TCCAC intron-variant
rs6458881 -- 52,844,454(+) TGAGT(C/T)GAAGA intron-variant
rs6458882 -- 52,844,898(+) TCTAT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTA5 Gene

Variant ID Type Subtype PubMed ID
nsv462945 CNV Loss 19166990
nsv470818 CNV Loss 18288195
esv2732085 CNV Deletion 23290073
nsv885883 CNV Gain 21882294
esv2436160 CNV Deletion 19546169
esv2732088 CNV Deletion 23290073
esv2673977 CNV Deletion 23128226
nsv482097 CNV Gain 20164927
esv2732089 CNV Deletion 23290073

Variation tolerance for GSTA5 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GSTA5 Gene

Disorders for GSTA5 Gene

Relevant External Links for GSTA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GSTA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTA5 Gene

Publications for GSTA5 Gene

  1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PMID: 12042665) Morel F. … Guillouzo A. (Pharmacogenetics 2002) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes. (PMID: 12076520) Kazi S. … Ellis E.M. (Chem. Biol. Interact. 2002) 25 26
  5. Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases. (PMID: 10085232) McDonagh P.D. … Roberts G.C. (Biochem. J. 1999) 25 26

Products for GSTA5 Gene

Sources for GSTA5 Gene