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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSTA4 Gene

protein-coding   GIFtS: 67
GCID: GC06M052842

Glutathione S-Transferase Alpha 4

(Previous name: glutathione S-transferase A4)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione S-Transferase Alpha 41 2     GTA42
Glutathione S-Transferase A41 2     Glutathione S-Alkyltransferase A42
Glutathione S-Transferase A4-42 3     Glutathione S-Aralkyltransferase A42
GST Class-Alpha Member 42 3     Glutathione S-Aryltransferase A42
EC 2.5.1.183 8     Glutathione Transferase A4-42
GSTA4-42     S-(Hydroxyalkyl)Glutathione Lyase A42

External Ids:    HGNC: 46291   Entrez Gene: 29412   Ensembl: ENSG000001708997   OMIM: 6054505   UniProtKB: O152173   

Export aliases for GSTA4 gene to outside databases

Previous GC identifers: GC06M052844 GC06M052889 GC06M052950 GC06M052674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTA4 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active
electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione
S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on
chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the
detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been
linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract
formation, and atherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTA4 Gene: 
GSTA4 (glutathione S-transferase alpha 4) is a protein-coding gene. Diseases associated with GSTA4 include dissecting aortic aneurysm, and malignant pleural mesothelioma, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include glutathione transferase activity and protein homodimerization activity. An important paralog of this gene is GSTA2.

UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal
(4-HNE)

Gene Wiki entry for GSTA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSTA4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Nkx2-5   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSTA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052842:  view genomic region     (about GC identifiers)

Start:
52,842,746 bp from pter      End:
52,860,178 bp from pter
Size:
17,433 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217 (See protein sequence)
Recommended Name: Glutathione S-transferase A4  
Size: 222 amino acids; 25704 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for GSTA4:
1GUL (3D)        1GUM (3D)        3IK7 (3D)    
Secondary accessions: B2RD15 Q5T7Q8 Q9BX18 Q9H414

Explore the universe of human proteins at neXtProt for GSTA4: NX_O15217

Explore proteomics data for GSTA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15217

  • 4/5 DME Specific Peptides for GSTA4 (O15217) (see all 5)
     SNIPTIK  RYFPVFEK  FLVGNQLS  LAAAGVEF 

    GSTA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSTA4 Protein Expression
    REFSEQ proteins: NP_001503.1  
    ENSEMBL proteins: 
     ENSP00000360002   ENSP00000359999   ENSP00000359998   ENSP00000394228   ENSP00000439439  
    Reactome Protein details: O15217
    Human Recombinant Protein Products for GSTA4: 
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    OriGene MassSpec for GSTA4 
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    Novus Biologicals GSTA4 Proteins
    Novus Biologicals GSTA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GSTA4
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    GSTA4 for ontologies           About GeneDecksing



    GSTA4 Antibody Products: 
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    Abcam antibodies for GSTA4
    Browse Antibodies at Cloud-Clone Corp. 
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    LSBio Antibodies in human, mouse, rat for GSTA4 

    Assay Products for GSTA4: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    5/6 InterPro protein domains (see all 6):
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N

    Graphical View of Domain Structure for InterPro Entry O15217

    ProtoNet protein and cluster: O15217

    2 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTA4_HUMAN, O15217
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal
    (4-HNE)
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTA4:
    glutathione S-transferase,alpha 4,ubiquitously expressed

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA10329152
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IPI10329152
         
    GSTA4 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gsta4):
     cellular  homeostasis/metabolism  immune system  reproductive system  skeleton 

    GSTA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gsta4tm1Pzim for GSTA4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSTA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSTA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTA4 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate GSTA4:
    hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-450b-3p hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidGSTA4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for GSTA4
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: GSTA4 (NM_001512)
    Sino Biological Human cDNA Clone for GSTA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA4
    Sirion Biotech Customized lentivirus for stable overexpression of GSTA4 
                         Customized lentivirus expression plasmids for stable overexpression of GSTA4 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GSTA4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione conjugation0.60
    Glutathione metabolism0.67
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    4Metabolism
    Metabolism0.40
    5Acetaminophen metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for GSTA4
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism


    2 GeneGo (Thomson Reuters) Pathways for GSTA4
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism

    3 BioSystems Pathways for GSTA4
        glutathione-mediated detoxification I
    metapathway biotransformation
    4-hydroxy-2-nonenal detoxification


    4        Reactome Pathways for GSTA4
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation


    4         Kegg Pathways  (Kegg details for GSTA4):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTA4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSTA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for GSTA4 (O152172 ENSP000003599984) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTA4O152172MINT-68483
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH5ENSP000002964124STRING: ENSP00000296412
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA10329152
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1901687glutathione derivative biosynthetic process TAS--

    GSTA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GSTA4 for compounds           About GeneDecksing

    EMD Millipore small molecules for GSTA4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSTA4

    10/13 HMDB Compounds for GSTA4 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Hydroxynonenal4-hydroxynon-2-enal (see all 5)75899-68-215288119
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--

    1 DrugBank Compound for GSTA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17553661

    3 Novoseek inferred chemical compound relationships for GSTA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-hydroxynonenal 86.3 39 20085333 (6), 18782442 (3), 19482077 (1), 9461507 (1) (see all 10)
    gsts 84.8 3 12833161 (1), 16054170 (1), 18664505 (1)
    lipid 45.9 10 9461507 (1), 12230403 (1), 17561509 (1), 20085333 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about GSTA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSTA4 gene: 
    NM_001512.3  

    Unigene Cluster for GSTA4:

    Glutathione S-transferase alpha 4
    Hs.485557  [show with all ESTs]
    Unigene Representative Sequence: BC071631
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486559 ENST00000477599 ENST00000370963(uc003pbf.3) ENST00000370960
    ENST00000370959 ENST00000457564 ENST00000541324(uc003pbd.3)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGSTA4 3' UTR sequence
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    Clone
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    Additional mRNA sequence: 

    AF020918.1 AF025887.1 AF125271.1 AF125272.1 AF125273.1 AK074541.1 AK125212.1 AK315369.1 
    BC015523.2 BC063439.1 BC071631.1 Y13047.1 

    18 DOTS entries:

    DT.456142  DT.447913  DT.95208217  DT.102844276  DT.121406104  DT.447912  DT.100795806  DT.121406239 
    DT.121406141  DT.87015516  DT.95271705  DT.95271709  DT.95333186  DT.100795800  DT.121406134  DT.92439624 
    DT.100738501  DT.100795808 

    24/271 AceView cDNA sequences (see all 271):

    Y13047 AV710933 AF125272 AA777798 CR604578 CR625957 BC063439 CR599141 
    AA354972 AA297257 CA314433 BM700452 CR597241 W42486 CA393326 CB154935 
    W42533 AF125271 AU099427 AI554147 BF436349 AA581750 AI918155 CA424585 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for GSTA4 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^
    SP1:                                -     -     -           -     -           -                             -     -     -                 -     -               
    SP2:                                -     -     -           -     -           -     -     -     -     -     -     -     -                 -     -               
    SP3:                                -     -     -           -     -           -                       -     -     -     -     -           -     -               
    SP4:                                                                          -                             -     -     -                 -     -               
    SP5:                                                                          -           -     -     -     -     -     -                 -     -               

    ExUns: 9a · 9b · 9c · 9d · 9e · 9f
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for GSTA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSTA4 expression in normal human tissues (normalized intensities)      GSTA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGTAGCC
    GSTA4 Expression
    About this image


    GSTA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Cardiac Fibroblasts Myocardium
             heart/ventricle   
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             sensory organ/nose/nasal cavity   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Caudal Endochondral Bones
             sensory organ/ear/inner ear   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Ureter
             visceral organ   

    See GSTA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSTA4

    SOURCE GeneReport for Unigene cluster: Hs.485557

    UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217
    Tissue specificity: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and
    liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including GSTA4: 
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              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GSTA4 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsta45 glutathione S-transferase, alpha 4   --   9 (43.65 cM) 78191966 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739626
    gstal6
    (see all 3)
    glutathione S-transferase, alpha-like
    (see all 3)
    53(a)
    53(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    13(707116-712513)
    13(715869-724232)


    ENSEMBL Gene Tree for GSTA4 (if available)
    TreeFam Gene Tree for GSTA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSTA4 gene
    GSTA22  GSTA52  HPGDS2  GSTA32  GSTA12  
    5 SIMAP similar genes for GSTA4 using alignment to 3 protein entries:     GSTA4_HUMAN (see all proteins):
    GSTA2    GSTA3    GSTA5    GSTA1    GSTalpha locus

    GSTA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/399 SNPs in GSTA4 are shown (see all 399)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668454271,2
    C--52842295(+) TCTCA-/AACTCCTGACC
    TCAGGTGATCTAC
    AACTC
    2 -- ds5001 cds10--------
    rs6437291,2
    C,H--52842302(+) CTCCTC/GACCTC 1 -- ds50010--------
    rs6441001,2
    C--52842371(+) GGGAGC/ACCCTG 1 -- ds50018Minor allele frequency- A:0.34WA NA EA 368
    rs1897791781,2
    --52842572(+) GGAAGC/GGTACA 1 -- ds50010--------
    rs37988091,2
    C,F--52842688(-) TTGCAC/TGGTTC 1 -- ds50012Minor allele frequency- T:0.01EA WA 1426
    rs1813677311,2
    --52842717(+) AAAAAC/TTAATT 1 -- ds50010--------
    rs4057291,2
    C,F,A,H--52842781(-) TCAGTG/ATTAGC 1 -- ut3142Minor allele frequency- A:0.37MN NS EA NA WA 5816
    rs455478371,2
    C,F--52842784(-) CAATCA/GGTGTT 1 -- ut315Minor allele frequency- G:0.00NS 190
    rs74961,2
    C,F,A,H--52842839(-) GTCTAG/ATAAAT 1 -- ut31 ese342Minor allele frequency- A:0.17MN EA NA NS WA CSA 6166
    rs176147511,2
    C,F,H--52842849(+) CATTCG/AGTTGT 1 -- ut31 ese327Minor allele frequency- A:0.04NA NS EA MN WA 2640

    HapMap Linkage Disequilibrium report for GSTA4 (52842746 - 52860178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTA4:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1954e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605450    OMIM disorders: --

    20/27 diseases for GSTA4 (see all 27):    About MalaCards
    dissecting aortic aneurysm    malignant pleural mesothelioma    barrett's adenocarcinoma    toxic encephalopathy
    atherosclerosis    noma    parkinson's disease    schistosomiasis
    cataract    aortic aneurysm    alzheimer's disease    brain disease
    cytochrome p450    oral cancer    infertility    astrocytoma
    pancreatic cancer    hepatitis b    lung cancer    hepatocellular carcinoma

    14 diseases from the University of Copenhagen DISEASES database for GSTA4:
    Carcinoma     Hepatocellular carcinoma     Lung cancer     Schistosomiasis
    Colorectal cancer     Breast cancer     Liver disease     Prostate cancer
    Urinary bladder cancer     Vascular disease     Asthma     Toxic encephalopathy
    Adenoma     Leukemia

    GSTA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for GSTA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 14.8 1 15064094 (1)
    parkinson disease 6.78 1 16054170 (1)

    Genetic Association Database (GAD): GSTA4
    Human Genome Epidemiology (HuGE) Navigator: GSTA4 (24 documents)

    Export disorders for GSTA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSTA4 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with GSTA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PubMed id 9480897)1, 2, 3, 9 Board P.G. (1998)
    2. Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. (PubMed id 20085333)1, 2, 9 Balogh L.M....Atkins W.M. (2010)
    3. Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (PubMed id 20097730)1, 4, 9 Tang H....Li D. (2010)
    4. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (PubMed id 10329152)1, 2, 9 Bruns C.M.... Tainer J.A. (1999)
    5. Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. (PubMed id 9461507)1, 2, 9 Hubatsch I.... Mannervik B. (1998)
    6. Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (PubMed id 16054170)1, 4, 9 Coppede F....Migliore L. (2005)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    8. Glutathione pathway genetic polymorphisms and lung ca ncer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (2010)
    9. Evidence that Gsta4 modifies susceptibility to skin t umor development in mice and humans. (PubMed id 20966433)1, 4 Abel E.L....DiGiovanni J. (2010)
    10. SNPs in genes coding for ROS metabolism and signallin g in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2941 HGNC: 4629 AceView: GSTA4 Ensembl:ENSG00000170899 euGenes: HUgn2941
    ECgene: GSTA4 Kegg: 2941 H-InvDB: GSTA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSTA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTA4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gsta4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSTA4 gene:
    Search GeneIP for patents involving GSTA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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