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Aliases for GSTA4 Gene

Aliases for GSTA4 Gene

  • Glutathione S-Transferase Alpha 4 2 3 5
  • Glutathione S-Transferase A4-4 3 4
  • Glutathione S-Transferase A4 2 3
  • GST Class-Alpha Member 4 3 4
  • EC 2.5.1.18 4 61
  • S-(Hydroxyalkyl)Glutathione Lyase A4 3
  • Glutathione S-Aralkyltransferase A4 3
  • Glutathione S-Alkyltransferase A4 3
  • Glutathione S-Aryltransferase A4 3
  • Glutathione Transferase A4-4 3
  • GSTA4-4 3
  • GTA4 3

External Ids for GSTA4 Gene

Previous GeneCards Identifiers for GSTA4 Gene

  • GC06M052844
  • GC06M052889
  • GC06M052674
  • GC06M052842

Summaries for GSTA4 Gene

Entrez Gene Summary for GSTA4 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA4 Gene

GSTA4 (Glutathione S-Transferase Alpha 4) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTA2.

UniProtKB/Swiss-Prot for GSTA4 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).

Gene Wiki entry for GSTA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA4 Gene

Genomics for GSTA4 Gene

Regulatory Elements for GSTA4 Gene

Enhancers for GSTA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F053481 1.2 FANTOM5 Ensembl ENCODE 14 -487.8 -487818 3.6 PKNOX1 MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 GSTA4 TRAM2 RN7SL244P TMEM14A GSTA1 GC06P053483 GC06M053483
GH06F052663 1 ENCODE 14 +331.0 330986 2.5 PKNOX1 ARNT WRNIP1 ARID4B YBX1 DMAP1 ZNF2 YY1 ZNF143 FOS LOC730101 IL17F LOC724104 RPL31P28 TMEM14A GSTA4 EFHC1 TRAM2 TRAM2-AS1 ICK
GH06F053346 1.1 ENCODE 14 -352.9 -352891 3.5 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 DMAP1 YY1 FOS ZNF263 GSTA4 TRAM2 RN7SL244P TMEM14A ELOVL5 GC06P053343
GH06F052918 0.8 Ensembl ENCODE 8.4 +75.7 75662 3.4 ELF3 FEZF1 RFX5 RARA YY1 FOS CREM THAP11 SMARCC1 NFYA GSTA4 GSTA3 LRRC1 GC06P052940
GH06F052908 0.6 ENCODE 8.2 +85.7 85734 3.1 RFX1 HLF ZNF558 GSTA4 GSTA3 GSTA10P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GSTA4 on UCSC Golden Path with GeneCards custom track

Promoters for GSTA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001218600 80 3800 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1

Genomic Location for GSTA4 Gene

Chromosome:
6
Start:
52,977,948 bp from pter
End:
52,995,380 bp from pter
Size:
17,433 bases
Orientation:
Minus strand

Genomic View for GSTA4 Gene

Genes around GSTA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA4 Gene

Proteins for GSTA4 Gene

  • Protein details for GSTA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15217-GSTA4_HUMAN
    Recommended name:
    Glutathione S-transferase A4
    Protein Accession:
    O15217
    Secondary Accessions:
    • B2RD15
    • Q5T7Q8
    • Q6P4G1
    • Q9BX18
    • Q9H414

    Protein attributes for GSTA4 Gene

    Size:
    222 amino acids
    Molecular mass:
    25704 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTA4 Gene

    Alternative splice isoforms for GSTA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTA4 Gene

Selected DME Specific Peptides for GSTA4 Gene

Post-translational modifications for GSTA4 Gene

  • Ubiquitination at Lys 127 and Lys 138
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTA4 Gene

Domains & Families for GSTA4 Gene

Gene Families for GSTA4 Gene

Suggested Antigen Peptide Sequences for GSTA4 Gene

Graphical View of Domain Structure for InterPro Entry

O15217

UniProtKB/Swiss-Prot:

GSTA4_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Alpha family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA4: view

Function for GSTA4 Gene

Molecular function for GSTA4 Gene

GENATLAS Biochemistry:
glutathione S-transferase,alpha 4,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).

Enzyme Numbers (IUBMB) for GSTA4 Gene

Gene Ontology (GO) - Molecular Function for GSTA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0042803 protein homodimerization activity IPI 10329152
genes like me logo Genes that share ontologies with GSTA4: view
genes like me logo Genes that share phenotypes with GSTA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTA4

miRNA for GSTA4 Gene

miRTarBase miRNAs that target GSTA4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTA4 Gene

Localization for GSTA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTA4 Gene COMPARTMENTS Subcellular localization image for GSTA4 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
extracellular 2
golgi apparatus 2
lysosome 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GSTA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GSTA4: view

Pathways & Interactions for GSTA4 Gene

genes like me logo Genes that share pathways with GSTA4: view

Gene Ontology (GO) - Biological Process for GSTA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 10329152
GO:0006805 xenobiotic metabolic process IDA 10329152
GO:0008152 metabolic process IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTA4: view

No data available for SIGNOR curated interactions for GSTA4 Gene

Drugs & Compounds for GSTA4 Gene

(5) Drugs for GSTA4 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Water Approved Pharma 0
LB42708 Pharma Selective FTase inhibitor, Selective farnesyltransferase (FTase) inhibitor 0
Lonafarnib Pharma Ftase inhibitor,potent and selective 0
Trichloroethylene Pharma 5

(42) Additional Compounds for GSTA4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxynonenal
  • 4-Hydroxy-2,3-nonenal
  • 4-Hydroxy-2-Nonenal
  • 4-Hydroxynon-2-enal
  • 4-Hydroxynonenal
  • trans-4-Hydroxy-2-nonenal
75899-68-2
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide

(2) ApexBio Compounds for GSTA4 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTA4: view

Transcripts for GSTA4 Gene

Unigene Clusters for GSTA4 Gene

Glutathione S-transferase alpha 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - -
SP15: - - - - - - -
SP16: - - -
SP17: - - - - - - - - - - - - -
SP18: - - -

ExUns: 9a · 9b · 9c · 9d · 9e · 9f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GSTA4 Gene

GeneLoc Exon Structure for
GSTA4
ECgene alternative splicing isoforms for
GSTA4

Expression for GSTA4 Gene

mRNA expression in normal human tissues for GSTA4 Gene

mRNA differential expression in normal tissues according to GTEx for GSTA4 Gene

This gene is overexpressed in Adrenal Gland (x8.9).

Protein differential expression in normal tissues from HIPED for GSTA4 Gene

This gene is overexpressed in Adrenal (19.9), Fetal testis (18.5), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTA4 Gene



NURSA nuclear receptor signaling pathways regulating expression of GSTA4 Gene:

GSTA4

SOURCE GeneReport for Unigene cluster for GSTA4 Gene:

Hs.485557

mRNA Expression by UniProt/SwissProt for GSTA4 Gene:

O15217-GSTA4_HUMAN
Tissue specificity: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
genes like me logo Genes that share expression patterns with GSTA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for GSTA4 Gene

Orthologs for GSTA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTA4 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia GSTA4 34 35
  • 91.14 (n)
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia GSTA4 34 35
  • 90.39 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTA4 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSTA4 35
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsta3 35
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GSTA 35
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstal 35
  • 53 (a)
ManyToMany
zgc:173961 35
  • 53 (a)
ManyToMany
zgc:173962 35
  • 53 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-10 35
  • 26 (a)
ManyToMany
gst-41 35
  • 26 (a)
ManyToMany
F56A4.4 35
  • 25 (a)
ManyToMany
Y45G12C.3 35
  • 25 (a)
ManyToMany
F56A4.3 35
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for GSTA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTA4 Gene

ENSEMBL:
Gene Tree for GSTA4 (if available)
TreeFam:
Gene Tree for GSTA4 (if available)

Paralogs for GSTA4 Gene

Paralogs for GSTA4 Gene

(5) SIMAP similar genes for GSTA4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSTA4: view

Variants for GSTA4 Gene

Sequence variations from dbSNP and Humsavar for GSTA4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10557482 -- 52,982,885(+) AGGGG(-/GAGA)GAGAG intron-variant
rs10658673 -- 52,980,311(+) TTTTT(-/T/TTT/TTTT)GAGAC intron-variant
rs10710892 -- 52,980,312(+) CTTTG(-/T)TTTTT intron-variant
rs10948734 -- 52,984,725(+) CCCTA(A/G)AAGCA intron-variant
rs111521565 -- 52,982,377(+) CTTCA(A/G/T)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTA4 Gene

Variant ID Type Subtype PubMed ID
esv2759430 CNV loss 17122850

Variation tolerance for GSTA4 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA4 Gene

Disorders for GSTA4 Gene

Relevant External Links for GSTA4

Genetic Association Database (GAD)
GSTA4
Human Genome Epidemiology (HuGE) Navigator
GSTA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTA4

No disorders were found for GSTA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTA4 Gene

Publications for GSTA4 Gene

  1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board P.G. (Biochem. J. 1998) 2 3 4 22 64
  2. Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. (PMID: 20085333) Balogh L.M. … Atkins W.M. (Biochemistry 2010) 3 4 22 64
  3. Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (PMID: 20097730) Tang H. … Li D. (Carcinogenesis 2010) 3 22 46 64
  4. Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (PMID: 16054170) CoppedA" F. … Migliore L. (Mutat. Res. 2005) 3 22 46 64
  5. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (PMID: 10329152) Bruns C.M. … Tainer J.A. (J. Mol. Biol. 1999) 3 4 22 64

Products for GSTA4 Gene

  • Cloud-Clone Corp. Antibodies for GSTA4
  • Cloud-Clone Corp. Proteins for GSTA4
  • Cloud-Clone Corp Assay Kits for GSTA4

Sources for GSTA4 Gene

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