Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GSTA4 Gene

protein-coding   GIFtS: 68
GCID: GC06M052842

Glutathione S-Transferase Alpha 4

(Previous name: glutathione S-transferase A4)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutathione S-Transferase Alpha 41 2     GTA42
Glutathione S-Transferase A41 2     Glutathione S-Alkyltransferase A42
Glutathione S-Transferase A4-42 3     Glutathione S-Aralkyltransferase A42
GST Class-Alpha Member 42 3     Glutathione S-Aryltransferase A42
EC 2.5.1.183 8     Glutathione Transferase A4-42
GSTA4-42     S-(Hydroxyalkyl)Glutathione Lyase A42

External Ids:    HGNC: 46291   Entrez Gene: 29412   Ensembl: ENSG000001708997   OMIM: 6054505   UniProtKB: O152173   

Export aliases for GSTA4 gene to outside databases

Previous GC identifers: GC06M052844 GC06M052889 GC06M052950 GC06M052674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GSTA4 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active
electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione
S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on
chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the
detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been
linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract
formation, and atherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTA4 Gene:
GSTA4 (glutathione S-transferase alpha 4) is a protein-coding gene. Diseases associated with GSTA4 include dissecting aortic aneurysm, and malignant pleural mesothelioma. GO annotations related to this gene include glutathione transferase activity and protein homodimerization activity. An important paralog of this gene is GSTA2.

UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal
(4-HNE)

Gene Wiki entry for GSTA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTA4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Nkx2-5   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTA4 promoter sequence
   Search Chromatin IP Primers for GSTA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052842:  view genomic region     (about GC identifiers)

Start:
52,842,746 bp from pter      End:
52,860,178 bp from pter
Size:
17,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217 (See protein sequence)
Recommended Name: Glutathione S-transferase A4  
Size: 222 amino acids; 25704 Da
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for GSTA4:
1GUL (3D)        1GUM (3D)        3IK7 (3D)    
Secondary accessions: B2RD15 Q5T7Q8 Q9BX18 Q9H414

Explore the universe of human proteins at neXtProt for GSTA4: NX_O15217

Explore proteomics data for GSTA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127, Lys138
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTA4 (O15217) (see all 5)
     SNIPTIK  RYFPVFEK  FLVGNQLS  LAAAGVEF 


    See GSTA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001503.1  
    ENSEMBL proteins: 
     ENSP00000360002   ENSP00000359999   ENSP00000359998   ENSP00000394228   ENSP00000439439  
    Reactome Protein details: O15217

    GSTA4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GSTA4
    OriGene Protein Over-expression Lysate for GSTA4
    OriGene MassSpec for GSTA4
    OriGene Custom Protein Services for GSTA4
    GenScript Custom Purified and Recombinant Proteins Services for GSTA4
    Novus Biologicals GSTA4 Proteins
    Novus Biologicals GSTA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTA4
    Browse Proteins at Cloud-Clone Corp.

    GSTA4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GSTA4
    OriGene Custom Antibody Services for GSTA4
    Novus Biologicals GSTA4 Antibodies
    Abcam antibodies for GSTA4
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for GSTA4
    LSBio Antibodies in human, mouse, rat for GSTA4

    GSTA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GSTA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GSTA4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O15217

    ProtoNet protein and cluster: O15217

    2 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    GSTA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTA4_HUMAN, O15217
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal
    (4-HNE)
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTA4:
    glutathione S-transferase,alpha 4,ubiquitously expressed

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA10329152
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IPI10329152
         
    GSTA4 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gsta4):
     cellular  homeostasis/metabolism  immune system  reproductive system  skeleton 

    GSTA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gsta4tm1Pzim for GSTA4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSTA4:
    hsa-mir-185-5p (MIRT045335)

    Block miRNA regulation of human, mouse, rat GSTA4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate GSTA4:
    hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-450b-3p hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidGSTA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTA4
    Predesigned siRNA for gene silencing in human, mouse, rat GSTA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTA4

    Clone
    Products:
         
    OriGene clones in human, mouse for GSTA4 (see all 8)
    OriGene ORF clones in mouse, rat for GSTA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTA4 (NM_001512)
    Sino Biological Human cDNA Clone for GSTA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GSTA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GSTA4_HUMAN, O15217: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome2
    vacuole2
    endosome1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    GSTA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GSTA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione metabolism0.65
    4-hydroxy-2-nonenal detoxification0.00
    Glutathione conjugation0.60
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    52 Naphthylamine and 2 Nitronaphtalene metabolism
    2 Naphthylamine and 2 Nitronaphtalene metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for GSTA4
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism

    3 BioSystems Pathways for GSTA4
        glutathione-mediated detoxification I
    metapathway biotransformation
    4-hydroxy-2-nonenal detoxification


    1 Reactome Pathway for GSTA4
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for GSTA4):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    GSTA4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTA4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GSTA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTA4 (O152172 ENSP000003599984) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTA4O152172MINT-68483
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH5ENSP000002964124STRING: ENSP00000296412
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA10329152
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1901687glutathione derivative biosynthetic process TAS--

    GSTA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTA4

    Selected HMDB Compounds for GSTA4 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Hydroxynonenal4-hydroxynon-2-enal (see all 5)75899-68-215288119
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--

    1 DrugBank Compound for GSTA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17553661

    3 Novoseek inferred chemical compound relationships for GSTA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-hydroxynonenal 86.3 39 20085333 (6), 18782442 (3), 19482077 (1), 9461507 (1) (see all 10)
    gsts 84.8 3 12833161 (1), 16054170 (1), 18664505 (1)
    lipid 45.9 10 9461507 (1), 12230403 (1), 17561509 (1), 20085333 (1) (see all 8)



    GSTA4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GSTA4 gene: 
    NM_001512.3  

    Unigene Cluster for GSTA4:

    Glutathione S-transferase alpha 4
    Hs.485557  [show with all ESTs]
    Unigene Representative Sequence: BC071631
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486559 ENST00000477599 ENST00000370963(uc003pbf.3) ENST00000370960
    ENST00000370959 ENST00000457564 ENST00000541324(uc003pbd.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GSTA4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate GSTA4:
    hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-450b-3p hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidGSTA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSTA4
    Predesigned siRNA for gene silencing in human, mouse, rat GSTA4
    Clone
    Products:
         
    OriGene clones in human, mouse for GSTA4 (see all 8)
    OriGene ORF clones in mouse, rat for GSTA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTA4 (NM_001512)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GSTA4
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GSTA4
      QuantiTect SYBR Green Assays in human, mouse, rat GSTA4
      QuantiFast Probe-based Assays in human, mouse, rat GSTA4

    Additional mRNA sequence: 

    AF020918.1 AF025887.1 AF125271.1 AF125272.1 AF125273.1 AK074541.1 AK125212.1 AK315369.1 
    BC015523.2 BC063439.1 BC071631.1 Y13047.1 

    18 DOTS entries:

    DT.456142  DT.447913  DT.95208217  DT.102844276  DT.121406104  DT.447912  DT.100795806  DT.121406239 
    DT.121406141  DT.87015516  DT.95271705  DT.95271709  DT.95333186  DT.100795800  DT.121406134  DT.92439624 
    DT.100738501  DT.100795808 

    Selected AceView cDNA sequences (see all 271):

    W42533 CR597241 AF125271 BE796228 BI826694 AA297257 BM698104 BI754166 
    AI583968 CR594939 NM_001512 CR604578 AI554147 BP371356 AA418695 BM700452 
    AA777851 AI918155 AI366085 CR613653 AV654086 AA759194 AA354972 AA581750 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GSTA4 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^
    SP1:                                -     -     -           -     -           -                             -     -     -                 -     -               
    SP2:                                -     -     -           -     -           -     -     -     -     -     -     -     -                 -     -               
    SP3:                                -     -     -           -     -           -                       -     -     -     -     -           -     -               
    SP4:                                                                          -                             -     -     -                 -     -               
    SP5:                                                                          -           -     -     -     -     -     -                 -     -               

    ExUns: 9a · 9b · 9c · 9d · 9e · 9f
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for GSTA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GSTA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGTAGCC
    GSTA4 Expression
    About this image


    GSTA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Caudal Endochondral Bones
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
    GSTA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485557

    UniProtKB/Swiss-Prot: GSTA4_HUMAN, O15217
    Tissue specificity: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and
    liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTA4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSTA4
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GSTA4
    QuantiTect SYBR Green Assays in human, mouse, rat GSTA4
    QuantiFast Probe-based Assays in human, mouse, rat GSTA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GSTA4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsta45 glutathione S-transferase, alpha 4   --   9 (43.65 cM) 78191966 
    chicken
    (Gallus gallus)
    Aves GSTA6
    Gallus gallus glutathione S-transferase class-alph...
    59(a)
    many ↔ many
    3(87829502-87837950)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Glutathione S-transferase
    62(a)
    many ↔ many
    1(151705719-151770639)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739616
    gstal6
    (see all 3)
    glutathione S-transferase, alpha-like
    (see all 3)
    53(a)
    53(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    13(701311-704057) ENSDARG00000039832
    13(715869-724232) ENSDARG00000090228
    worm
    (Caenorhabditis elegans)
    Secernentea gst-416
    gst-106
    (see all 5)
    Protein GST-10 (gst-10) mRNA, complete cds
    (see all 5)
    26(a)
    26(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    V(7398465-7399302) WBGene00001789
    V(2561690-2564708) WBGene00001758


    ENSEMBL Gene Tree for GSTA4 (if available)
    TreeFam Gene Tree for GSTA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GSTA4 gene
    GSTA22  GSTA52  HPGDS2  GSTA32  GSTA12  
    5 SIMAP similar genes for GSTA4 using alignment to 3 protein entries:     GSTA4_HUMAN (see all proteins):
    GSTA2    GSTA5    GSTA1    GSTA3    GSTalpha locus

    GSTA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GSTA4 (see all 399)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668454271,2
    C--52842295(+) TCTCA-/AACTCCTGACC
    TCAGGTGATCTAC
    AACTC
    2 -- ds5001 cds10--------
    rs6437291,2
    C,H--52842302(+) CTCCTC/GACCTC 1 -- ds50010--------
    rs6441001,2
    C--52842371(+) GGGAGC/ACCCTG 1 -- ds50018Minor allele frequency- A:0.34WA NA EA 368
    rs1897791781,2
    --52842572(+) GGAAGC/GGTACA 1 -- ds50010--------
    rs37988091,2
    C,F--52842688(-) TTGCAC/TGGTTC 1 -- ds50012Minor allele frequency- T:0.01EA WA 1426
    rs1813677311,2
    --52842717(+) AAAAAC/TTAATT 1 -- ds50010--------
    rs4057291,2
    C,F,A,H--52842781(-) TCAGTG/ATTAGC 1 -- ut3142Minor allele frequency- A:0.37MN NS EA NA WA 5816
    rs455478371,2
    C,F--52842784(-) CAATCA/GGTGTT 1 -- ut315Minor allele frequency- G:0.00NS 190
    rs74961,2
    C,F,A,H--52842839(-) GTCTAG/ATAAAT 1 -- ut31 ese342Minor allele frequency- A:0.17MN EA NA NS WA CSA 6166
    rs176147511,2
    C,F,H--52842849(+) CATTCG/AGTTGT 1 -- ut31 ese327Minor allele frequency- A:0.04NA NS EA MN WA 2640

    HapMap Linkage Disequilibrium report for GSTA4 (52842746 - 52860178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSTA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1954e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTA4
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605450    OMIM disorders: --

    Selected diseases for GSTA4 (see all 40):    
    About MalaCards
    dissecting aortic aneurysm    malignant pleural mesothelioma    toxic encephalopathy    barrett's adenocarcinoma
    noma    atherosclerosis    parkinson's disease    cataract
    schistosomiasis    aortic aneurysm    lung cancer susceptibility    alzheimer's disease
    labyrinthitis    brain disease    oral cancer    vascular disease
    astrocytoma    infertility    endotheliitis    liver disease

    14 diseases from the University of Copenhagen DISEASES database for GSTA4:
    Carcinoma     Hepatocellular carcinoma     Lung cancer     Schistosomiasis
    Colorectal cancer     Breast cancer     Liver disease     Prostate cancer
    Urinary bladder cancer     Vascular disease     Asthma     Toxic encephalopathy
    Adenoma     Leukemia

    GSTA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for GSTA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 14.8 1 15064094 (1)
    parkinson disease 6.78 1 16054170 (1)

    Genetic Association Database (GAD): GSTA4
    Human Genome Epidemiology (HuGE) Navigator: GSTA4 (24 documents)

    Export disorders for GSTA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GSTA4 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with GSTA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PubMed id 9480897)1, 2, 3, 9 Board P.G. (Biochem. J. 1998)
    2. Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. (PubMed id 20085333)1, 2, 9 Balogh L.M.... Atkins W.M. (Biochemistry 2010)
    3. Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (PubMed id 20097730)1, 4, 9 Tang H....Li D. (Carcinogenesis 2010)
    4. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (PubMed id 10329152)1, 2, 9 Bruns C.M.... Tainer J.A. (J. Mol. Biol. 1999)
    5. Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. (PubMed id 9461507)1, 2, 9 Hubatsch I.... Mannervik B. (Biochem. J. 1998)
    6. Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (PubMed id 16054170)1, 4, 9 CoppedA" F....Migliore L. (Mutat. Res. 2005)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    8. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (amp 2010)
    9. Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. (PubMed id 20966433)1, 4 Abel E.L....DiGiovanni J. (J. Natl. Cancer Inst. 2010)
    10. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (Pharmacogenomics J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2941 HGNC: 4629 AceView: GSTA4 Ensembl:ENSG00000170899 euGenes: HUgn2941
    ECgene: GSTA4 Kegg: 2941 H-InvDB: GSTA4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GSTA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTA4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gsta4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GSTA4 gene:
    Search GeneIP for patents involving GSTA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GSTA4   OriGene RNAi products in human, mouse, rat for GSTA4  
     OriGene qPCR primer pairs and template standards for GSTA4   OriGene Protein Over-expression Lysate for GSTA4  
     OriGene MassSpec something-or-other for GSTA4   OriGene clones in human, mouse for GSTA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for GSTA4   OriGene Purified Protein for GSTA4  
     OriGene ORF clones in mouse, rat for GSTA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GSTA4   OriGene Custom Protein Services for GSTA4  

     
     
     Block miRNA regulation of human, mouse, rat GSTA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GSTA4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTA4 Predesigned siRNA for gene silencing in human, mouse, rat GSTA4
     QuantiFast Probe-based Assays in human, mouse, rat GSTA4 QuantiTect SYBR Green Assays in human, mouse, rat GSTA4
     PCR Arrays including human, mouse / rat GSTA4 Search Chromatin IP Primers for GSTA4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GSTA4  Search GeneGlobe Interaction Network for GSTA4
     Regulatory tfbs in GSTA4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GSTA4 GenScript cDNA clones with any tag delivered in your preferred vector for GSTA4
     GenScript Custom Assay Services for GSTA4 GenScript Custom overexpressing Cell Line Services for GSTA4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GSTA4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GSTA4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GSTA4 antibodies
     GSTA4 proteins
     GSTA4 lysates
     Antibodies for GSTA4
     See all of Abcam's Antibodies, Kits and Proteins for GSTA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GSTA4
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GSTA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA4
     SwitchGear 3'UTR luciferase reporter plasmids for GSTA4
     SwitchGear Promoter luciferase reporter plasmids for GSTA4
     Search ThermoFisher Antibodies for GSTA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTA4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTA4
     LSBio Antibodies in human, mouse, rat for GSTA4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GSTA4 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4