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Aliases for GSTA3 Gene

Aliases for GSTA3 Gene

  • Glutathione S-Transferase Alpha 3 2 3
  • Glutathione S-Transferase A3-3 3 4
  • GST Class-Alpha Member 3 3 4
  • EC 2.5.1.18 4 63
  • S-(Hydroxyalkyl)Glutathione Lyase A3 3
  • Glutathione S-Aralkyltransferase A3 3
  • Glutathione S-Alkyltransferase A3 3
  • Glutathione S-Aryltransferase A3 3
  • Glutathione S-Transferase A3 2
  • GSTA3-3 3
  • GTA3 3

External Ids for GSTA3 Gene

Previous GeneCards Identifiers for GSTA3 Gene

  • GC06M052763
  • GC06M052704
  • GC06M052808
  • GC06M052869
  • GC06M052761
  • GC06M052592

Summaries for GSTA3 Gene

Entrez Gene Summary for GSTA3 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA3 Gene

GSTA3 (Glutathione S-Transferase Alpha 3) is a Protein Coding gene. Diseases associated with GSTA3 include prostate leiomyosarcoma and skin carcinoma in situ. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA4.

UniProtKB/Swiss-Prot for GSTA3 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.

Gene Wiki entry for GSTA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA3 Gene

Genomics for GSTA3 Gene

Regulatory Elements for GSTA3 Gene

Transcription factor binding sites by QIAGEN in the GSTA3 gene promoter:

Genomic Location for GSTA3 Gene

Chromosome:
6
Start:
52,847,910 bp from pter
End:
52,909,798 bp from pter
Size:
61,889 bases
Orientation:
Minus strand

Genomic View for GSTA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA3 Gene

Proteins for GSTA3 Gene

  • Protein details for GSTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16772-GSTA3_HUMAN
    Recommended name:
    Glutathione S-transferase A3
    Protein Accession:
    Q16772
    Secondary Accessions:
    • O43468
    • Q068V6
    • Q8WWA8
    • Q9H415

    Protein attributes for GSTA3 Gene

    Size:
    222 amino acids
    Molecular mass:
    25302 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA74634.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD04712.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTA3 Gene

neXtProt entry for GSTA3 Gene

Proteomics data for GSTA3 Gene at MOPED

Post-translational modifications for GSTA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GSTA3

Domains & Families for GSTA3 Gene

Gene Families for GSTA3 Gene

Suggested Antigen Peptide Sequences for GSTA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16772

UniProtKB/Swiss-Prot:

GSTA3_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily. Alpha family.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA3: view

Function for GSTA3 Gene

Molecular function for GSTA3 Gene

GENATLAS Biochemistry:
glutathione S-transferase,alpha 3
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 uM for delta(5)-androstene-3,17-dione {ECO:0000269 PubMed:15595823}; Vmax=99 umol/min/mg enzyme for delta(5)-androstene-3,17-dione isomerization {ECO:0000269 PubMed:15595823};
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.

Enzyme Numbers (IUBMB) for GSTA3 Gene

Gene Ontology (GO) - Molecular Function for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GSTA3: view
genes like me logo Genes that share phenotypes with GSTA3: view

Animal Model Products

miRNA for GSTA3 Gene

miRTarBase miRNAs that target GSTA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTA3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GSTA3 Gene

Localization for GSTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTA3 Gene COMPARTMENTS Subcellular localization image for GSTA3 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
lysosome 2
mitochondrion 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GSTA3: view

Pathways & Interactions for GSTA3 Gene

genes like me logo Genes that share pathways with GSTA3: view

Pathways by source for GSTA3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GSTA3 Gene

Gene Ontology (GO) - Biological Process for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process ISS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0044281 small molecule metabolic process TAS --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTA3: view

No data available for SIGNOR curated interactions for GSTA3 Gene

Drugs & Compounds for GSTA3 Gene

(6) Drugs for GSTA3 Gene - From: HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
GSHNA Experimental Pharma Target 0
LB42708 Pharma Selective FTase inhibitor, Selective farnesyltransferase (FTase) inhibitor 0
Lonafarnib Pharma Ftase inhibitor,potent and selective 0

(41) Additional Compounds for GSTA3 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTA3: view

Transcripts for GSTA3 Gene

Unigene Clusters for GSTA3 Gene

Glutathione S-transferase alpha 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA3 Gene

No ASD Table

Relevant External Links for GSTA3 Gene

GeneLoc Exon Structure for
GSTA3
ECgene alternative splicing isoforms for
GSTA3

Expression for GSTA3 Gene

mRNA expression in normal human tissues for GSTA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA3 Gene

This gene is overexpressed in Adrenal Gland (x32.1), Skin - Not Sun Exposed (Suprapubic) (x6.4), and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for GSTA3 Gene

This gene is overexpressed in Fetal testis (23.0), Fetal ovary (17.3), and Adrenal (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTA3 Gene



SOURCE GeneReport for Unigene cluster for GSTA3 Gene Hs.102484

genes like me logo Genes that share expression patterns with GSTA3: view

Protein tissue co-expression partners for GSTA3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GSTA3 Gene

Orthologs for GSTA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSTA5 35
  • 83.03 (n)
  • 78.38 (a)
GSTA1 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia GSTA3 35
  • 87.09 (n)
  • 83.78 (a)
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gsta3 35
  • 78.64 (n)
  • 78.64 (a)
Gsta3 16
Gm8074 36
  • 68 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia GSTA3 35
  • 99.4 (n)
  • 99.1 (a)
GSTA3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsta3 35
  • 78.79 (n)
  • 75 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
ManyToMany
GSTA3 36
  • 62 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6393 35
zebrafish
(Danio rerio)
Actinopterygii gstal 36
  • 54 (a)
ManyToMany
zgc:173961 36
  • 54 (a)
ManyToMany
zgc:173962 36
  • 54 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F56A4.3 36
  • 28 (a)
ManyToMany
F56A4.4 36
  • 27 (a)
ManyToMany
gst-10 36
  • 27 (a)
ManyToMany
gst-41 36
  • 28 (a)
ManyToMany
Y45G12C.3 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for GSTA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTA3 Gene

ENSEMBL:
Gene Tree for GSTA3 (if available)
TreeFam:
Gene Tree for GSTA3 (if available)

Paralogs for GSTA3 Gene

Paralogs for GSTA3 Gene

(6) SIMAP similar genes for GSTA3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSTA3: view

Variants for GSTA3 Gene

Sequence variations from dbSNP and Humsavar for GSTA3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs526092 -- 52,906,450(+) cagaa(G/T)tggaa intron-variant
rs538920 -- 52,910,747(+) atgat(C/T)gaatc upstream-variant-2KB
rs563464 -- 52,911,074(+) AGTCT(C/T)AGCTG upstream-variant-2KB
rs568131 -- 52,911,608(+) gtgag(C/T)atttc upstream-variant-2KB
rs597169 -- 52,910,709(+) catcc(G/T)ctaat upstream-variant-2KB

Variation tolerance for GSTA3 Gene

Residual Variation Intolerance Score: 82.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTA3 Gene

HapMap Linkage Disequilibrium report
GSTA3
Human Gene Mutation Database (HGMD)
GSTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GSTA3 Gene

Disorders for GSTA3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GSTA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
skin carcinoma in situ
  • carcinoma in situ of scalp and skin of neck
dracunculiasis
  • infection by dracunculus medinensis
loiasis
  • african eye worm
parasitic ectoparasitic infectious disease
  • ectoparasitism
- elite association
Search GSTA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTA3

Genetic Association Database (GAD)
GSTA3
Human Genome Epidemiology (HuGE) Navigator
GSTA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSTA3
genes like me logo Genes that share disorders with GSTA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTA3 Gene

Publications for GSTA3 Gene

  1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board P.G. (Biochem. J. 1998) 2 25 26 67
  2. Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1. (PMID: 19850059) Ilic Z. … Sell S. (Toxicol. Appl. Pharmacol. 2010) 23 67
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. [Proteome study of colorectal cancer genesis and hepatic metastasis]. (PMID: 16313824) Bai X. … Cai H.Y. (Zhonghua Yi Xue Za Zhi 2005) 23 67

Products for GSTA3 Gene

Sources for GSTA3 Gene

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