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Aliases for GSTA3 Gene

Aliases for GSTA3 Gene

  • Glutathione S-Transferase Alpha 3 2 3 5
  • Glutathione S-Transferase A3-3 3 4
  • Glutathione S-Transferase A3 2 3
  • GST Class-Alpha Member 3 3 4
  • EC 4 56
  • S-(Hydroxyalkyl)Glutathione Lyase A3 3
  • Glutathione S-Aralkyltransferase A3 3
  • Glutathione S-Alkyltransferase A3 3
  • Glutathione S-Aryltransferase A3 3
  • GSTA3-3 3
  • GTA3 3

External Ids for GSTA3 Gene

Previous GeneCards Identifiers for GSTA3 Gene

  • GC06M052763
  • GC06M052704
  • GC06M052808
  • GC06M052869
  • GC06M052761
  • GC06M052592
  • GC06M052847

Summaries for GSTA3 Gene

Entrez Gene Summary for GSTA3 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA3 Gene

GSTA3 (Glutathione S-Transferase Alpha 3) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA1.

UniProtKB/Swiss-Prot for GSTA3 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.

Gene Wiki entry for GSTA3 Gene

Additional gene information for GSTA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA3 Gene

Genomics for GSTA3 Gene

GeneHancer (GH) Regulatory Elements for GSTA3 Gene

Promoters and enhancers for GSTA3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I052908 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +0.2 152 3.1 SKI RFX1 HLF FOS ZBTB17 GSTA3 GSTA4 GSTA10P
GH06I053064 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.9 -157.1 -157093 5.2 PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF207 FBXO9 MCM3 EFHC1 GSTA3 ICK GC06P053085
GH06I052992 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 -85.2 -85243 4.1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000202198 GC06P052997 GSTA4 RN7SK EFHC1 MCM3 ICK GSTA3 GC06P052982
GH06I053054 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -148.9 -148862 9.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ICK MCM3 TRAM2 GSTA3 FBXO9
GH06I052814 Enhancer 1.1 Ensembl ENCODE 11 +94.4 94361 1 ELF3 FOXA2 ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 ZNF335 ZNF143 GSTA6P PIR38149 GSTA1 GSTA3 ICK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GSTA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTA3 gene promoter:

Genomic Locations for GSTA3 Gene

Genomic Locations for GSTA3 Gene
13,160 bases
Minus strand

Genomic View for GSTA3 Gene

Genes around GSTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA3 Gene

Proteins for GSTA3 Gene

  • Protein details for GSTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione S-transferase A3
    Protein Accession:
    Secondary Accessions:
    • O43468
    • Q068V6
    • Q8WWA8
    • Q9H415

    Protein attributes for GSTA3 Gene

    222 amino acids
    Molecular mass:
    25302 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAA74634.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD04712.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTA3 Gene

neXtProt entry for GSTA3 Gene

Selected DME Specific Peptides for GSTA3 Gene


Post-translational modifications for GSTA3 Gene

No Post-translational modifications

Other Protein References for GSTA3 Gene

Domains & Families for GSTA3 Gene

Gene Families for GSTA3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTA3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GST superfamily. Alpha family.
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA3: view

Function for GSTA3 Gene

Molecular function for GSTA3 Gene

GENATLAS Biochemistry:
glutathione S-transferase,alpha 3
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 uM for delta(5)-androstene-3,17-dione {ECO:0000269 PubMed:15595823}; Vmax=99 umol/min/mg enzyme for delta(5)-androstene-3,17-dione isomerization {ECO:0000269 PubMed:15595823};
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.

Enzyme Numbers (IUBMB) for GSTA3 Gene

Phenotypes From GWAS Catalog for GSTA3 Gene

Gene Ontology (GO) - Molecular Function for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTA3: view
genes like me logo Genes that share phenotypes with GSTA3: view

Animal Models for GSTA3 Gene

MGI Knock Outs for GSTA3:

miRNA for GSTA3 Gene

miRTarBase miRNAs that target GSTA3

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTA3 Gene

Localization for GSTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTA3 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with GSTA3: view

Pathways & Interactions for GSTA3 Gene

genes like me logo Genes that share pathways with GSTA3: view

Gene Ontology (GO) - Biological Process for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process ISS --
GO:0008152 metabolic process IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTA3: view

No data available for SIGNOR curated interactions for GSTA3 Gene

Drugs & Compounds for GSTA3 Gene

(7) Drugs for GSTA3 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 594
Water Approved Pharma 0
GSHNA Experimental Pharma Target 0
LB42708 Pharma Selective FTase inhibitor, Selective farnesyltransferase (FTase) inhibitor 0

(40) Additional Compounds for GSTA3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTA3 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTA3: view

Drug Products

Transcripts for GSTA3 Gene

Unigene Clusters for GSTA3 Gene

Glutathione S-transferase alpha 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA3 Gene

No ASD Table

Relevant External Links for GSTA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSTA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA3 Gene

This gene is overexpressed in Adrenal Gland (x32.1), Skin - Not Sun Exposed (Suprapubic) (x6.4), and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for GSTA3 Gene

This gene is overexpressed in Fetal testis (23.0), Fetal ovary (17.3), and Adrenal (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTA3 Gene

Protein tissue co-expression partners for GSTA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTA3 Gene:


SOURCE GeneReport for Unigene cluster for GSTA3 Gene:


Evidence on tissue expression from TISSUES for GSTA3 Gene

  • Liver(3.2)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with GSTA3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA3 Gene

Orthologs for GSTA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GSTA3 33 34
  • 99.4 (n)
(Canis familiaris)
Mammalia GSTA3 33
  • 87.09 (n)
-- 34
  • 51 (a)
(Bos Taurus)
Mammalia GSTA5 33
  • 83.03 (n)
GSTA1 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Gsta3 33
  • 78.79 (n)
(Mus musculus)
Mammalia Gsta3 33 16
  • 78.64 (n)
Gm8074 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
(Gallus gallus)
Aves -- 34
  • 64 (a)
GSTA3 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
-- 34
  • 68 (a)
-- 34
  • 67 (a)
-- 34
  • 66 (a)
(Danio rerio)
Actinopterygii gstal 34
  • 54 (a)
zgc:173961 34
  • 54 (a)
zgc:173962 34
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6393 33
(Caenorhabditis elegans)
Secernentea F56A4.3 34
  • 28 (a)
gst-41 34
  • 28 (a)
F56A4.4 34
  • 27 (a)
gst-10 34
  • 27 (a)
Y45G12C.3 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for GSTA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTA3 Gene

Gene Tree for GSTA3 (if available)
Gene Tree for GSTA3 (if available)

Paralogs for GSTA3 Gene

Paralogs for GSTA3 Gene

(6) SIMAP similar genes for GSTA3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GSTA3: view

Variants for GSTA3 Gene

Sequence variations from dbSNP and Humsavar for GSTA3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000599548 -- 52,910,607(-) T/C upstream_transcript_variant
rs1000742786 -- 52,898,256(-) T/A intron_variant
rs1000773908 -- 52,903,230(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000826600 -- 52,902,981(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000945110 -- 52,903,546(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTA3 Gene

Variant ID Type Subtype PubMed ID
esv3609013 CNV loss 21293372
nsv970123 CNV duplication 23825009

Variation tolerance for GSTA3 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTA3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA3 Gene

Disorders for GSTA3 Gene

Additional Disease Information for GSTA3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GSTA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTA3 Gene

Publications for GSTA3 Gene

  1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board PG (The Biochemical journal 1998) 2 3 4 25 58
  2. Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity. (PMID: 15595823) Gu Y … Ji X (Biochemistry 2004) 3 4 22 58
  3. Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes. (PMID: 8307579) Suzuki T … Board PG (Genomics 1993) 2 3 4 58
  4. Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases. (PMID: 20083122) Tars K … Mannervik B (Journal of molecular biology 2010) 3 4 58
  5. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for GSTA3 Gene

Sources for GSTA3 Gene

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