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GSTA2 Gene

protein-coding   GIFtS: 63
GCID: GC06M052614

Glutathione S-Transferase Alpha 2

(Previous name: glutathione S-transferase A2)
(Previous symbol: GST2)
  See GSTA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione S-Transferase Alpha 21 2     EC 2.5.1.183 8
GST21 2 3 5     GTA22
Glutathione S-Transferase A21 2     Glutathione S-Alkyltransferase A22
GST-gamma2 3     Glutathione S-Aralkyltransferase A22
GSTA2-22 3     Glutathione S-Aryltransferase A22
GTH22 3     Liver GST22
GST Class-Alpha Member 22 3     S-(Hydroxyalkyl)Glutathione Lyase A22
GST HA Subunit 22 3     

External Ids:    HGNC: 46271   Entrez Gene: 29392   Ensembl: ENSG000002440677   OMIM: 1383605   UniProtKB: P092103   

Export aliases for GSTA2 gene to outside databases

Previous GC identifers: GC06M052617 GC06M052662 GC06M052723 GC06M052446


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSTA2 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic
drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding
these enzymes are known to be highly polymorphic. These genetic variations can change an individual's
susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present,
eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified:
alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the
alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly
expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer
drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting
the cells from reactive oxygen species and the products of peroxidation. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTA2 Gene:
GSTA2 (glutathione S-transferase alpha 2) is a protein-coding gene. Diseases associated with GSTA2 include toxic encephalopathy, and malignant pleural mesothelioma. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA4.

UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles

Gene Wiki entry for GSTA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTA2 gene promoter:
         Pbx1a   FOXD1   FOXD3   HNF-3beta   HNF-1A   C/EBPalpha   PPAR-gamma1   HFH-1   HNF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTA2 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052614:  view genomic region     (about GC identifiers)

Start:
52,614,885 bp from pter      End:
52,628,367 bp from pter
Size:
13,483 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210 (See protein sequence)
Recommended Name: Glutathione S-transferase A2  
Size: 222 amino acids; 25664 Da
Subunit: Homodimer or heterodimer of GSTA1 and GSTA2
4 PDB 3D structures from and Proteopedia for GSTA2:
1AGS (3D)        2VCT (3D)        2WJU (3D)        4ACS (3D)    
Secondary accessions: Q12759 Q16491 Q9NTY6

Explore the universe of human proteins at neXtProt for GSTA2: NX_P09210

Explore proteomics data for GSTA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTA2 (P09210) (see all 11)
     AAGVEFE  RYFPAFE  LVGNKLS  AGVEFEE 


    See GSTA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000837.3  
    ENSEMBL proteins: 
     ENSP00000420168  
    Reactome Protein details: P09210

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P09210

    ProtoNet protein and cluster: P09210

    2 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTA2_HUMAN, P09210
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTA2:
    glutathione S-transferase 2,alpha,expressed in liver,with a proximal promoter essential for the binding of
    activating transcription factor complexes

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity ISS--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GSTA2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GSTA2:
     Increased cell number in S and 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSTA2_HUMAN, P09210: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    mitochondrion2
    peroxisome2
    vacuole2
    endosome1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GSTA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSTA2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    3Biological oxidations
    Biological oxidations0.56
    Phase II conjugation0.56
    4Metabolism
    Metabolism0.38
    5One carbon pool by folate
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34


    Find genes that share SuperPaths with GSTA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for GSTA2
        Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Dichloroethylene metabolism
    Glutathione metabolism

    2 BioSystems Pathways for GSTA2
        AhR pathway
    Glutathione metabolism

    1 Reactome Pathway for GSTA2
        Glutathione conjugation

    1 PharmGKB Pathway for GSTA2
        Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    4 Kegg Pathways  (Kegg details for GSTA2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GSTA2
    Interactions:

        Search GeneGlobe Interaction Network for GSTA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTA2 (P092103 ENSP000004201684) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTA1P082633, ENSP000003356204I2D: score=1 STRING: ENSP00000335620
    GSTM2ENSP000002413374STRING: ENSP00000241337
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process ISS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0030855epithelial cell differentiation IEP--
    GO:0044281small molecule metabolic process TAS--
    GO:1901687glutathione derivative biosynthetic process TAS--

    Find genes that share ontologies with GSTA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTA2

    Selected HMDB Compounds for GSTA2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    7 DrugBank Compounds for GSTA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17401685 17338280 17321661 17317527 17338281
    enzymesubstrate17401685 17338280 17321661 17317527 17338281 1782341 15822171
    Ethacrynic acidEtacrinic acid (see all 6)58-54-8enzymeinhibitor9463521 15999103 8329448 9776312 8950226
    ClofibrateChlorfenisate (see all 11)637-07-0enzymeinhibitor6477642 3707598
    BusulfanBusulphan (see all 8)55-98-1enzymesubstrate18194479
    ChloroquineChloraquine (see all 6)54-05-7target--11752352
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9enzymeinducer20153624
    AzathioprineAzathioprin (see all 3)446-86-6enzymesubstrate--

    7 Novoseek inferred chemical compound relationships for GSTA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 87.5 9 10676639 (2), 8061957 (2), 12140174 (1), 11668220 (1) (see all 6)
    oltipraz 78.9 12 16714377 (4), 15155840 (2), 15319326 (1)
    tbhq 77.5 9 15357004 (3), 15155840 (1), 15319326 (1)
    c2ceramide 57 2 15155840 (1), 15319326 (1)
    phosphatidylinositol 34.1 1 15357004 (1)
    ceramide 29.7 6 15319326 (3), 15155840 (2)
    oxygen 0 3 19639209 (1)



    Find genes that share compounds with GSTA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GSTA2 gene: 
    NM_000846.4  

    Unigene Cluster for GSTA2:

    Glutathione S-transferase alpha 2
    Hs.94107  [show with all ESTs]
    Unigene Representative Sequence: NM_000846
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000493422(uc003pay.3)
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    Additional mRNA sequence: 

    AK292602.1 AK313601.1 BC002895.2 M16594.1 

    6 DOTS entries:

    DT.40133187  DT.452793  DT.100676914  DT.100676916  DT.100745080  DT.91702252 

    Selected AceView cDNA sequences (see all 152):

    AA846513 CB163833 BU949701 AV652178 AI261839 CR601508 AV703708 AV702143 
    AV653390 H69204 CA773680 AV656284 AV701016 BI762502 R83309 BV204434 
    AV648446 N52577 BX365400 CA773246 BU949992 AV657115 AV681855 CB145964 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSTA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GSTA2 Expression
    About this image


    GSTA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
    GSTA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.94107

    UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210
    Tissue specificity: Liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GSTA2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsta25 glutathione S-transferase, alpha 2 (Yc2)   --   9 (43.65 cM) 78331018 
    chicken
    (Gallus gallus)
    Aves GSTA1 glutathione S-transferase class-alpha 69.67(n)
    68.47(a)
      414895  NM_001001776.1  NP_001001776.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Glutathione S-transferase
    (see all 4)
    68(a)
    68(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(148460397-148466448)
    1(151781701-151787309)
    zebrafish
    (Danio rerio)
    Actinopterygii BC060914.12   -- 75.71(n)    BC060914.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-416
    F56A4.36
    (see all 5)
    Protein F56A4.3 (F56A4.3) mRNA, complete cds
    (see all 5)
    29(a)
    28(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    V(7398465-7399302) WBGene00001789
    V(2453414-2456147) WBGene00018911


    ENSEMBL Gene Tree for GSTA2 (if available)
    TreeFam Gene Tree for GSTA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSTA2 gene
    GSTA42  GSTA52  HPGDS2  GSTA32  GSTA12  
    6 SIMAP similar genes for GSTA2 using alignment to 1 protein entry:     GSTA2_HUMAN:
    GSTA1    GSTalpha locus    GSTA3    GSTA5    GSTA4    GSTP1

    Find genes that share paralogs with GSTA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSTA2 (see all 584)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs286613981,2
    C--52455591(+) TTTTTG/TTTTTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1839396991,2
    --52527361(+) TTGTAA/CGTGGA 1 -- ds50010--------
    rs1896349081,2
    C--52527380(+) TAGAGA/CAAAGT 1 -- ds50010--------
    rs1808638761,2
    --52527494(+) CCAGGA/TGTCCT 1 -- ds50010--------
    rs1476638921,2
    --52527527(+) CCAGTA/GTGGGG 1 -- ds50010--------
    rs47153141,2
    C,A--52527578(+) AGTGAT/CACACC 1 -- ds50015Minor allele frequency- C:0.37NA EA 246
    rs1859092891,2
    C--52527594(+) AAAATA/GATTTT 1 -- ds50010--------
    rs1423609291,2
    --52527624(+) TAATTC/TACATA 1 -- ds50010--------
    rs27490001,2
    C,F,A--52527656(+) CCAGGT/CCTGAG 1 -- ds50017Minor allele frequency- C:0.16NA WA CSA EA 249
    rs583585341,2
    C,F--52527743(+) GGACCA/CCATGC 1 -- ds50012Minor allele frequency- C:0.08WA 120

    HapMap Linkage Disequilibrium report for GSTA2 (52614885 - 52628367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GSTA2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666271CNV Deletion23128226
    esv2732085CNV Deletion23290073
    esv2436160CNV Deletion19546169
    esv4858CNV Duplication18987735
    nsv470818CNV Loss18288195
    esv9378CNV Loss19470904
    nsv462945CNV Loss19166990
    nsv523124CNV Loss19592680
    nsv885883CNV Gain21882294
    esv2752126CNV Gain17911159

    Human Gene Mutation Database (HGMD): GSTA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTA2
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138360    OMIM disorders: --

    3 diseases for GSTA2:    
    About MalaCards
    toxic encephalopathy    malignant pleural mesothelioma    periventricular nodular heterotopia

    14 diseases from the University of Copenhagen DISEASES database for GSTA2:
    Carcinoma     Hepatocellular carcinoma     Lung cancer     Schistosomiasis
    Colorectal cancer     Breast cancer     Liver disease     Prostate cancer
    Urinary bladder cancer     Vascular disease     Asthma     Toxic encephalopathy
    Adenoma     Leukemia

    Find genes that share disorders with GSTA2           About GenesLikeMe

    Genetic Association Database (GAD): GSTA2
    Human Genome Epidemiology (HuGE) Navigator: GSTA2 (22 documents)

    Export disorders for GSTA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSTA2 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with GSTA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form. (PubMed id 15128049)1, 4, 9 Ning B....Coles B. (Pharmacogenetics 2004)
    2. The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case-control study in the Portuguese population. (PubMed id 19639209)1, 4, 9 Silva S.N....Gaspar J.F. (Oncol. Rep. 2009)
    3. Polymorphism of human alpha class glutathione transferases. (PubMed id 11668220)1, 2, 9 Tetlow N.... Board P. (Pharmacogenetics 2001)
    4. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. (PubMed id 11692074)1, 4, 9 Coles B.F....Kadlubar F.F. (Pharmacogenetics 2001)
    5. Isolation and characterization of the human glutathione S-transferase A2 subunit gene. (PubMed id 1329668)1, 2, 9 Rohrdanz E.... Pickett C.B. (Arch. Biochem. Biophys. 1992)
    6. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PubMed id 19859803)1, 4, 9 Andonova I.E....Brauch H. (Breast Cancer Res. Treat. 2010)
    7. Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma. (PubMed id 17290392)1, 4, 9 Landi S....Puntoni R. (Int. J. Cancer 2007)
    8. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. (PubMed id 16006997)1, 4, 9 Landi S....Canzian F. (Pharmacogenet. Genomics 2005)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    10. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PubMed id 20200426)1, 4 Moyer A.M....Weinshilboum R.M. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2939 HGNC: 4627 AceView: GSTA2andGSTA3andGSTA5 Ensembl:ENSG00000244067 euGenes: HUgn2939
    ECgene: GSTA2 Kegg: 2939 H-InvDB: GSTA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GSTA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSTA2 gene:
    Search GeneIP for patents involving GSTA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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