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Aliases for GSTA2 Gene

Aliases for GSTA2 Gene

  • Glutathione S-Transferase Alpha 2 2 3
  • GST2 3 4 6
  • Glutathione S-Transferase A2 2 3
  • GST Class-Alpha Member 2 3 4
  • GST HA Subunit 2 3 4
  • EC 2.5.1.18 4 63
  • GST-Gamma 3 4
  • GSTA2-2 3 4
  • GTH2 3 4
  • S-(Hydroxyalkyl)Glutathione Lyase A2 3
  • Glutathione S-Aralkyltransferase A2 3
  • Glutathione S-Alkyltransferase A2 3
  • Glutathione S-Aryltransferase A2 3
  • Liver GST2 3
  • GTA2 3

External Ids for GSTA2 Gene

Previous HGNC Symbols for GSTA2 Gene

  • GST2

Previous GeneCards Identifiers for GSTA2 Gene

  • GC06M052617
  • GC06M052662
  • GC06M052723
  • GC06M052614
  • GC06M052446

Summaries for GSTA2 Gene

Entrez Gene Summary for GSTA2 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA2 Gene

GSTA2 (Glutathione S-Transferase Alpha 2) is a Protein Coding gene. Diseases associated with GSTA2 include toxic encephalopathy and malignant pleural mesothelioma. Among its related pathways are AhR pathway (WikiPathways) and Metabolism. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA4.

UniProtKB/Swiss-Prot for GSTA2 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

Gene Wiki entry for GSTA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA2 Gene

Genomics for GSTA2 Gene

Regulatory Elements for GSTA2 Gene

Genomic Location for GSTA2 Gene

Start:
52,750,087 bp from pter
End:
52,763,569 bp from pter
Size:
13,483 bases
Orientation:
Minus strand

Genomic View for GSTA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA2 Gene

Proteins for GSTA2 Gene

  • Protein details for GSTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09210-GSTA2_HUMAN
    Recommended name:
    Glutathione S-transferase A2
    Protein Accession:
    P09210
    Secondary Accessions:
    • Q12759
    • Q16491
    • Q9NTY6

    Protein attributes for GSTA2 Gene

    Size:
    222 amino acids
    Molecular mass:
    25664 Da
    Quaternary structure:
    • Homodimer or heterodimer of GSTA1 and GSTA2.

    Three dimensional structures from OCA and Proteopedia for GSTA2 Gene

neXtProt entry for GSTA2 Gene

Proteomics data for GSTA2 Gene at MOPED

Post-translational modifications for GSTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GSTA2 Gene

Gene Families for GSTA2 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

Suggested Antigen Peptide Sequences for GSTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09210

UniProtKB/Swiss-Prot:

GSTA2_HUMAN :
  • P09210
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA2: view

Function for GSTA2 Gene

Molecular function for GSTA2 Gene

GENATLAS Biochemistry: glutathione S-transferase 2,alpha,expressed in liver,with a proximal promoter essential for the binding of activating transcription factor complexes
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

Enzyme Numbers (IUBMB) for GSTA2 Gene

Gene Ontology (GO) - Molecular Function for GSTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity ISS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GSTA2: view

Phenotypes for GSTA2 Gene

GenomeRNAi human phenotypes for GSTA2:
genes like me logo Genes that share phenotypes with GSTA2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTA2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GSTA2 Gene

Localization for GSTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTA2 Gene COMPARTMENTS Subcellular localization image for GSTA2 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
mitochondrion 2
peroxisome 2
vacuole 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GSTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GSTA2: view

Pathways for GSTA2 Gene

genes like me logo Genes that share pathways with GSTA2: view

Gene Ontology (GO) - Biological Process for GSTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process ISS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0044281 small molecule metabolic process TAS --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTA2: view

Compounds for GSTA2 Gene

(12) HMDB Compounds for GSTA2 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(8) Drugbank Compounds for GSTA2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Azathioprine
  • Azathioprin
446-86-6 enzyme substrate
Busulfan
  • Busulphan
55-98-1 enzyme substrate
Chloroquine
  • Chloraquine
54-05-7 target
Clofibrate
  • Chlorfenisate
637-07-0 enzyme inhibitor
Ethacrynic acid
  • Etacrinic acid
58-54-8 enzyme inhibitor

(7) Novoseek inferred chemical compound relationships for GSTA2 Gene

Compound -log(P) Hits PubMed IDs
gsts 87.5 8
oltipraz 78.9 7
tbhq 77.5 5
c2ceramide 57 2
phosphatidylinositol 34.1 1
genes like me logo Genes that share compounds with GSTA2: view

Transcripts for GSTA2 Gene

mRNA/cDNA for GSTA2 Gene

(4) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSTA2 Gene

Glutathione S-transferase alpha 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSTA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA2 Gene

No ASD Table

Relevant External Links for GSTA2 Gene

GeneLoc Exon Structure for
GSTA2
ECgene alternative splicing isoforms for
GSTA2

Expression for GSTA2 Gene

mRNA expression in normal human tissues for GSTA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA2 Gene

This gene is overexpressed in Liver (18.1), Pancreas (15.8), and Kidney - Cortex (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GSTA2 Gene

SOURCE GeneReport for Unigene cluster for GSTA2 Gene Hs.94107

mRNA Expression by UniProt/SwissProt for GSTA2 Gene

P09210-GSTA2_HUMAN
Tissue specificity: Liver
genes like me logo Genes that share expressions with GSTA2: view

In Situ Assay Products

Orthologs for GSTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTA2 35
  • 99.4 (n)
  • 99.1 (a)
GSTA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTA5 36
  • 77 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm10639 36
  • 73 (a)
ManyToMany
Gsta2 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC501110 35
  • 78.08 (n)
  • 71.62 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
ManyToMany
GSTA 35
  • 69.67 (n)
  • 68.47 (a)
GSTA3 36
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstal 36
  • 54 (a)
ManyToMany
zgc:173961 36
  • 53 (a)
ManyToMany
zgc:173962 36
  • 54 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F56A4.3 36
  • 28 (a)
ManyToMany
F56A4.4 36
  • 26 (a)
ManyToMany
gst-10 36
  • 27 (a)
ManyToMany
gst-41 36
  • 29 (a)
ManyToMany
Y45G12C.3 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for GSTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTA2 Gene

ENSEMBL:
Gene Tree for GSTA2 (if available)
TreeFam:
Gene Tree for GSTA2 (if available)

Paralogs for GSTA2 Gene

Paralogs for GSTA2 Gene

Selected SIMAP similar genes for GSTA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GSTA2: view

Variants for GSTA2 Gene

Sequence variations from dbSNP and Humsavar for GSTA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6577 - 52,750,617(-) GGATG(A/C)GAAAT reference, missense
rs1009062 -- 52,758,955(-) CTGAG(A/C)AAGTT intron-variant
rs1009063 -- 52,758,707(-) GGGAT(A/T)AACAA intron-variant
rs1009064 -- 52,758,692(-) TGTCT(C/G)TTGAA intron-variant
rs1803682 -- 52,750,658(-) AAGAA(G/T)TTTCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GSTA2 Gene

Variant ID Type Subtype PubMed ID
nsv462945 CNV Loss 19166990
nsv470818 CNV Loss 18288195
nsv523124 CNV Loss 19592680
esv2752126 CNV Gain 17911159
esv2732085 CNV Deletion 23290073
esv9378 CNV Loss 19470904
esv4858 CNV Duplication 18987735
nsv885883 CNV Gain 21882294
dgv1952e1 CNV Complex 17122850
esv2436160 CNV Deletion 19546169
esv2666271 CNV Deletion 23128226

Relevant External Links for GSTA2 Gene

HapMap Linkage Disequilibrium report
GSTA2
Human Gene Mutation Database (HGMD)
GSTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA2 Gene

Disorders for GSTA2 Gene

Relevant External Links for GSTA2

Genetic Association Database (GAD)
GSTA2
Human Genome Epidemiology (HuGE) Navigator
GSTA2
genes like me logo Genes that share disorders with GSTA2: view

No data available for UniProtKB/Swiss-Prot for GSTA2 Gene

Publications for GSTA2 Gene

  1. Isolation and characterization of the human glutathione S-transferase A2 subunit gene. (PMID: 1329668) Rohrdanz E. … Pickett C.B. (Arch. Biochem. Biophys. 1992) 3 4 23
  2. Polymorphism of human alpha class glutathione transferases. (PMID: 11668220) Tetlow N. … Board P. (Pharmacogenetics 2001) 3 4 23
  3. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. (PMID: 11692074) Coles B.F. … Kadlubar F.F. (Pharmacogenetics 2001) 3 23 48
  4. Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form. (PMID: 15128049) Ning B. … Coles B. (Pharmacogenetics 2004) 3 23 48
  5. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. (PMID: 16006997) Landi S. … Canzian F. (Pharmacogenet. Genomics 2005) 3 23 48

Products for GSTA2 Gene

Sources for GSTA2 Gene

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