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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSTA2 Gene

protein-coding GIFtS: 64
GCID: GC06M052614

glutathione S-transferase alpha 2

(Previous name: glutathione S-transferase A2 )
(Previous symbol: GST2)

Explore 35 diseases affiliated with
GSTA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutathione S-Transferase Alpha 2¹ ²		EC 2.5.1.18³ ⁸
GST2¹ ² ³ ⁵		GTA2²
Glutathione S-Transferase A2¹ ²		Glutathione S-Alkyltransferase A2²
GST-Gamma¹		Glutathione S-Aralkyltransferase A2²
GSTA2-2² ³		Glutathione S-Aryltransferase A2²
GTH2² ³		Liver GST2²
GST Class-Alpha Member 2² ³		S-(Hydroxyalkyl)Glutathione Lyase A2²
GST HA Subunit 2² ³

External Ids:	HGNC: 4627¹	Entrez Gene: 2939²	Ensembl: ENSG00000244067⁷	OMIM: 138360⁵	UniProtKB: P09210³

Export aliases for GSTA2 gene to outside databases

Previous GC identifers: GC06M052617 GC06M052662 GC06M052723 GC06M052446

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSTA2:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These

enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs,

environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these

enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to

carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes

of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi,

sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class

genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in

liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these

enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the

products of peroxidation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

summary for GSTA2:

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both

eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic,

xenobiotic substrates, thus aiding excretion from the body.

Gene Wiki entry for GSTA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSTA2 gene promoter:
Pbx1a FOXD1 FOXD3 HNF-3beta HNF-1A C/EBPalpha PPAR-gamma1 HFH-1 HNF-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSTA2 promoter sequence

Search SABiosciences Chromatin IP Primers for GSTA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSTA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.2 HGNC cytogenetic band: 6p12.2

GSTA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M052614: view genomic region (about GC identifiers)

Start:	52,614,885 bp from pter	End:	52,628,367 bp from pter
Size:	13,483 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210 (See protein sequence)

Recommended Name: Glutathione S-transferase A2

Size: 222 amino acids; 25664 Da

Subunit: Homodimer or heterodimer of GSTA1 and GSTA2

Subcellular location: Cytoplasm

4 PDB 3D structures from and Proteopedia for GSTA2:

1AGS (3D)

2VCT (3D)

2WJU (3D)

4ACS (3D)

Secondary accessions: Q12759 Q16491 Q9NTY6

Explore the universe of human proteins at neXtProt for GSTA2: NX_P09210

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09210

4/11 DME Specific Peptides for GSTA2 (P09210) (see all 11)

AAGVEFE

RYFPAFE

LVGNKLS

AGVEFEE

GSTA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000837.3

ENSEMBL proteins:

ENSP00000420168

Reactome Protein details: P09210
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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

GSTA2 for ontologies About GeneDecksing

GSTA2 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSTA2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012336 Thioredoxin-like_fold

IPR003080 GST_alpha

IPR004046 GST_C

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR004045 Glutathione_S-Trfase_N

Graphical View of Domain Structure for InterPro Entry P09210

ProtoNet protein and cluster: P09210

2 Blocks protein families:

IPB003080 Alpha-class glutathione S-transferase signature

IPB004045 Glutathione S-transferase

UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210

Similarity: Belongs to the GST superfamily. Alpha family

Similarity: Contains 1 GST C-terminal domain

Similarity: Contains 1 GST N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Genatlas biochemistry entry for GSTA2:

glutathione S-transferase 2,alpha,expressed in liver,with a proximal promoter essential for the binding of activating

transcription factor complexes

Enzyme Number (IUBMB): EC 2.5.1.18¹ ²

miRNA Products:		OriGene 3'-UTR Clone: GSTA2 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	ISS	--

GSTA2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GSTA2:

Increased cell number in S and

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

Glutathione metabolism	1.00	glutathione-mediated detoxification I	0.53
Glutathione metabolism	0.92	Glutathione conjugation	0.50
Glutathione metabolism	0.70

2-Naphthylamine and 2-Nitronaphtalene metabolism

2-Naphthylamine and 2-Nitronaphtalene metabolism

1.00

2-Naphthylamine and 2-Nitronaphtalene metabolism

0.95

Dichloroethylene metabolism

Dichloroethylene metabolism

1.00

Dichloroethylene metabolism

1.00

Naphthalene metabolism

Naphthalene metabolism

1.00

Naphthalene metabolism

1.00

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for GSTA2

	Dichloroethylene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Naphthalene metabolism
	Glutathione metabolism

4 GeneGo (Thomson Reuters) Pathways for GSTA2

	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Dichloroethylene metabolism
	Glutathione metabolism

1 BioSystems Pathway for GSTA2

glutathione-mediated detoxification I

4 Reactome Pathways for GSTA2

	Metabolism
	Biological oxidations
	Glutathione conjugation
	Phase II conjugation

1 PharmGKB Pathway for GSTA2

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

3 Kegg Pathways (Kegg details for GSTA2):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

GSTA2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GSTA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for GSTA2 (P09210³ ENSP00000420168⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSTA1	P08263³, ENSP00000335620⁴	I2D: score=1 STRING: ENSP00000335620
GSTM2	ENSP00000241337⁴	STRING: ENSP00000241337
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH1B	ENSP00000306606⁴	STRING: ENSP00000306606
ADH4	ENSP00000265512⁴	STRING: ENSP00000265512

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006749	glutathione metabolic process	ISS	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

GSTA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSTA2 for compounds About GeneDecksing

EMD Millipore small molecules for GSTA2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for GSTA2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ellagic acid	Selective inhibitor of CK2. Also inhibits glutathione S-transferase	[476-66-4]

10/12 HMDB Compounds for GSTA2 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

6 DrugBank Compounds for GSTA2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17401685 17338280 17321661 17317527 17338281
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	enzyme	substrate	17401685 17338280 17321661 17317527 17338281 1782341 15822171
Ethacrynic acid	Etacrinic acid (see all 6)	58-54-8	enzyme	inhibitor	9463521 15999103 8329448 9776312 8950226
Clofibrate	Chlorfenisate (see all 11)	637-07-0	enzyme	inhibitor	6477642 3707598
Busulfan	Busulphan (see all 8)	55-98-1	enzyme	substrate	18194479
Chloroquine	Chloraquine (see all 6)	54-05-7	target	--	11752352
Vitamin E	alpha-Tocopherol (see all 2)	59-02-9	enzyme	inducer	20153624

7 Novoseek chemical compound relationships for GSTA2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	87.5	9	10676639 (2), 8061957 (2), 12140174 (1), 11668220 (1) (see all 6)
oltipraz	78.9	12	16714377 (4), 15155840 (2), 15319326 (1)
tbhq	77.5	9	15357004 (3), 15155840 (1), 15319326 (1)
c2ceramide	57	2	15155840 (1), 15319326 (1)
phosphatidylinositol	34.1	1	15357004 (1)
ceramide	29.7	6	15319326 (3), 15155840 (2)
oxygen	0	3	19639209 (1)

Search CenterWatch for drugs/clinical trials and news about GSTA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSTA2 gene:

NM_000846.4

Unigene Cluster for GSTA2:

Glutathione S-transferase alpha 2

Hs.94107 [show with all ESTs]

Unigene Representative Sequence: NM_000846

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000493422(uc003pay.3)

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Additional cDNA sequence:

AK292602.1 AK313601.1 BC002895.2 M16594.1

6 DOTS entries:

DT.40133187 DT.452793 DT.100676914 DT.100676916 DT.100745080 DT.91702252

24/152 AceView cDNA sequences (see all 152):

AV702143 AI261839 AV652178 H69204 AV703708 AA846513 BU949701 CR601508

CB163833 AV653390 M16594 BV204430 BU570753 BI762502 AV706836 BX365400

BV204538 N71016 NM_000846 BV204434 R83309 AV657115 BE795593 BX506437

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSTA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

GSTA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

Endoderm progenitor-like cells (Generation and expan...)

Embryoid bodies (Two-step protocol fo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GSTA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSTA2

SOURCE GeneReport for Unigene cluster: Hs.94107

UniProtKB/Swiss-Prot: GSTA2_HUMAN, P09210

Tissue specificity: Liver

SABiosciences Custom PCR Arrays for GSTA2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GSTA2 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GSTA1_CHICK⁶	Glutathione S-transferase	63(a)	1 → many	3(91202951-91209673)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	68(a) 68(a) (see all 4)	many ↔ many many ↔ many (see all 4)	1(151781701-151787309) 1(151805371-151845842)
zebrafish (Danio rerio)	Actinopterygii	BC060914.1²	--	75.71(n)		BC060914.1

ENSEMBL Gene Tree for GSTA2 (if available)
TreeFam Gene Tree for GSTA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSTA2 gene

GSTA4² GSTA5² GSTA3² GSTA1² GSTM1² GSTM3² GSTP1² GSTM4²

HPGDS² GSTM5² GSTM2²

6 SIMAP similar genes for GSTA2 using alignment to 1 protein entry: GSTA2_HUMAN:

GSTA1 GSTalpha locus GSTA5 GSTA3 GSTA4 GSTP1

GSTA2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58358534^1,2	C,	--	52445991(+)	`GGACCA/CCATGC`	1	--	ds500¹		2		WA	120
rs56104766^1,2	C,	--	52446014(+)	`AACAAG/CGTGGC`	1	--	ds500¹		2		WA	120
rs59453153^1,2		--	52446077(+)	`AAAACG/TGAGGA`	1	--	ds500¹		2		CSA WA	119
rs55712103^1,2	C,	--	52446102(+)	`GAATCG/ATTGTT`	1	--	ds500¹		4		WA CSA	122
rs9349642^1,2		--	52446196(+)	`CAGGAC/TGGTAA`	1	--	ut3¹		0	--	--	--	--
rs55935488^1,2	C,F,	--	52446234(+)	`TCAGAG/AGTGCA`	1	--	ut3¹		4		WA CSA	123
rs2234952^1,2	C,F,H,,	--	52446444(-)	`CCTATT/ACACCC`	1	--	ut3¹		25		NA MN NS EA WA	3754
rs114264491^1,2	C,F,	--	52446455(+)	`AGTTGT/CATTAT`	1	--	ut3¹		1		WA	118
rs1803682^1,2	C	--	52446674(-)	`AAGAAG/TTTTCT`	2	K N	mis¹		1		NA	2
rs73740504^1,2	C,F,	--	52446823(+)	`TGAGTC/TGCTTC`	1	--	int¹		4		WA CSA	125

HapMap Linkage Disequilibrium report for GSTA2 (52614885 - 52628367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for GSTA2
3 CNVs: 2630 8515 99540
1 Indel: 43717
Human Gene Mutation Database (HGMD): GSTA2

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSTA2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GSTA2 for disorders           About GeneDecksing

OMIM gene information: 138360    OMIM disorders: --

20/35 diseases for GSTA2 (see all 35):    About MalaCards

periventricular nodular heterotopia intestinal volvulus malignant pleural mesothelioma heterotopia

urinary bladder cancer toxic encephalopathy polymicrogyria chronic lymphocytic leukemia

lymphocytic leukemia multiple myeloma schistosomiasis neurodegenerative disease

hepatitis b skin cancer hermaphroditism oral cancer

myeloma hepatocellular carcinoma infertility colorectal cancer

Genetic Association Database (GAD): GSTA2
Human Genome Epidemiology (HuGE) Navigator: GSTA2 (22 documents)

Export disorders for GSTA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GSTA2 gene, integrated from 9 sources (see all 100):
(articles sorted by number of sources associating them with GSTA2)

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world of online information

Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form. (PubMed id 15128049)^{1, 4, 9} Ning B....Coles B. (2004)
Polymorphism of human alpha class glutathione transferases. (PubMed id 11668220)^{1, 2, 9} Tetlow N.... Board P. (2001)
Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. (PubMed id 11692074)^{1, 4, 9} Coles B.F....Kadlubar F.F. (2001)
Isolation and characterization of the human glutathione S-transferase A2 subunit gene. (PubMed id 1329668)^{1, 2, 9} Rohrdanz E.... Pickett C.B. (1992)
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. (PubMed id 16006997)^{1, 4, 9} Landi S....Canzian F. (2005)
Structural basis for featuring of steroid isomerase a ctivity in alpha class glutathione transferases. (PubMed id 20083122)^{1, 2} Tars K....Mannervik B. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
A surface mutant (G82R) of a human alpha-glutathione S-transferase shows decreased thermal stability and a new mode of molecular association in the crystal. (PubMed id 7892174)^{1, 2} Zeng K.... Wang B.C. (1994)
Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver. (PubMed id 8431482)^{1, 2} Ahmad H.... Awasthi Y.C. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2939	HGNC: 4627	AceView: GSTA2andGSTA3andGSTA5	Ensembl:ENSG00000244067	euGenes: HUgn2939
ECgene: GSTA2	Kegg: 2939	H-InvDB: GSTA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GSTA2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GSTA2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GSTA2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GSTA2 gene:
Search GeneIP for patents involving GSTA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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glutathione S-transferase alpha 2

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