Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GSTA1 Gene

protein-coding   GIFtS: 67
GCID: GC06M052656

Glutathione S-Transferase Alpha 1

(Previous name: glutathione S-transferase A1)
  See GSTA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutathione S-Transferase Alpha 11 2     GST22
Glutathione S-Transferase A11 2     Glutathione S-Alkyltransferase A12
GST-epsilon2 3     Glutathione S-Aryltransferase A12
GSTA1-12 3     Glutathione S-Transferase 22
GTH12 3     Glutathione S-Transferase Ha Subunit 12
GST Class-Alpha Member 12 3     GST, Class Alpha, 12
GST HA Subunit 12 3     S-(Hydroxyalkyl)Glutathione Lyase A12
EC 2.5.1.183 8     

External Ids:    HGNC: 46261   Entrez Gene: 29382   Ensembl: ENSG000002439557   OMIM: 1383595   UniProtKB: P082633   

Export aliases for GSTA1 gene to outside databases

Previous GC identifers: GC06M052658 GC06M052657 GC06M052703 GC06M052764 GC06M052486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GSTA1 Gene:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic
drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding
these enzymes are known to be highly polymorphic. These genetic variations can change an individual's
susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present,
eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified:
alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the
alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly
expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer
drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting
the cells from reactive oxygen species and the products of peroxidation. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSTA1 Gene:
GSTA1 (glutathione S-transferase alpha 1) is a protein-coding gene. Diseases associated with GSTA1 include toxic encephalopathy. GO annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA2.

UniProtKB/Swiss-Prot: GSTA1_HUMAN, P08263
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles

Gene Wiki entry for GSTA1 (Glutathione S-transferase A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSTA1 gene promoter:
         Sp1   AP-1   ATF-2   Lmo2   FOXD1   AP-4   Nkx2-5   HNF-1A   HNF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSTA1 promoter sequence
   Search Chromatin IP Primers for GSTA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12.2

GSTA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSTA1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052656:  view genomic region     (about GC identifiers)

Start:
52,656,178 bp from pter      End:
52,668,708 bp from pter
Size:
12,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GSTA1_HUMAN, P08263 (See protein sequence)
Recommended Name: Glutathione S-transferase A1  
Size: 222 amino acids; 25631 Da
Subunit: Homodimer or heterodimer of GSTA1 and GSTA2
Selected PDB 3D structures from and Proteopedia for GSTA1 (see all 27):
1GSD (3D)        1GSE (3D)        1GSF (3D)        1GUH (3D)        1K3L (3D)        1K3O (3D)    
Secondary accessions: Q14750 Q5GHF8 Q5SZC1

Explore the universe of human proteins at neXtProt for GSTA1: NX_P08263

Explore proteomics data for GSTA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSTA1 (P08263) (see all 12)
     AAGVEFE  RYFPAFE  LVGNKLS  AGVEFEE 


    See GSTA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_665683.1  
    ENSEMBL proteins: 
     ENSP00000335620  
    Reactome Protein details: P08263

    GSTA1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant GSTA1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GSTA1
    OriGene Protein Over-expression Lysate for GSTA1
    OriGene MassSpec for GSTA1
    OriGene Custom Protein Services for GSTA1
    GenScript Purified and Recombinant Proteins for GSTA1
    Novus Biologicals GSTA1 Proteins
    Novus Biologicals GSTA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GSTA1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GSTA1 

     
    antibodies-online proteins for GSTA1 (30 products) 

     
    Search antibodies-online for peptides for GSTA1

    GSTA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSTA1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GSTA1
    OriGene Custom Antibody Services for GSTA1
    Novus Biologicals GSTA1 Antibodies
    Abcam antibodies for GSTA1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GSTA1
    LSBio Antibodies in human, mouse, rat for GSTA1
    antibodies-online antibodies for GSTA1 (68 products) 

    GSTA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GSTA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GSTA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GSTA1 
    antibodies-online kits for GSTA1 (33 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SGST: Glutathione S-transferases / Soluble

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR003080 GST_alpha
     IPR004046 GST_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry P08263

    ProtoNet protein and cluster: P08263

    2 Blocks protein domains:
    IPB003080 Alpha-class glutathione S-transferase signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: GSTA1_HUMAN, P08263
    Domain: The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast
    appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity
    Similarity: Belongs to the GST superfamily. Alpha family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with GSTA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSTA1_HUMAN, P08263
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for GSTA1:
    glutathione S-transferase 1,alpha,expressed in liver,with a proximal promoter essential for the binding of
    activating transcription factor complexes

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity NAS1731620
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GSTA1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSTA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSTA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSTA1:
    hsa-mir-26b-5p (MIRT029138)

    Block miRNA regulation of human, mouse, rat GSTA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GSTA1
    SwitchGear 3'UTR luciferase reporter plasmidGSTA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSTA1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSTA1

    Clone
    Products:
         
    OriGene clones in human, mouse for GSTA1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTA1 (NM_145740)
    Sino Biological Human cDNA Clone for GSTA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GSTA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GSTA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GSTA1_HUMAN, P08263: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome2
    vacuole2
    endosome1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GSTA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GSTA1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    Glutathione conjugation0.60
    4-hydroxy-2-nonenal detoxification0.00
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    3Biological oxidations
    Biological oxidations0.56
    Phase II conjugation0.56
    4Metabolism
    Metabolism0.38
    5One carbon pool by folate
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34


    Find genes that share SuperPaths with GSTA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for GSTA1
        Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Glutathione metabolism

    4 BioSystems Pathways for GSTA1
        glutathione-mediated detoxification I
    AhR pathway
    Glutathione metabolism
    4-hydroxy-2-nonenal detoxification


    1 Reactome Pathway for GSTA1
        Glutathione conjugation

    2 PharmGKB Pathways for GSTA1
        Busulfan Pathway, Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    4 Kegg Pathways  (Kegg details for GSTA1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTA1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSTA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSTA1 (P082633 ENSP000003356204) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTA2P092103, ENSP000004201684I2D: score=1 STRING: ENSP00000420168
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH5ENSP000002964124STRING: ENSP00000296412
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IDA11851347
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008152metabolic process IC3800996
    GO:0030855epithelial cell differentiation IEP--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with GSTA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSTA1

    Selected HMDB Compounds for GSTA1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    9 DrugBank Compounds for GSTA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17425746 17346923 10592235 17333241
    enzymesubstrate17425746 17346923 10592235 17333241 1782341 15822171
    BusulfanBusulphan (see all 8)55-98-1enzymesubstrate20672371 16448639 18194479
    Glutathione Sulfonic Acid-- --target--17139284 17016423 10592235
    S-Hydroxycysteine-- --target--17139284 17016423 10592235
    2-Hydroxyethyl Disulfide-- 1892-29-1target----
    enzyme----
    AzathioprineAzathioprin (see all 3)446-86-6enzymesubstrate--
    N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine-- --target----
    enzyme----
    S-Benzyl-Glutathione-- --target----
    enzyme----
    S-Hexylglutathione-- --target----
    enzyme----

    Selected Novoseek inferred chemical compound relationships for GSTA1 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 87.9 8 16608922 (2), 8330352 (1), 15128049 (1), 10053036 (1) (see all 7)
    sulforaphane 77 16 15090468 (6), 12151360 (3), 20204301 (2), 12756216 (1) (see all 6)
    busulfan 61.3 9 12429583 (2), 15779864 (2), 17425746 (1), 16448639 (1) (see all 7)
    androstane 57.2 2 17112801 (1), 16204462 (1)
    gamma-glutamylcysteine 47 2 19176875 (1), 16356128 (1)
    12-dichloroethane 46.9 5 11673082 (3), 8330352 (1)
    ethacrynic acid 45.1 2 11297599 (1), 16802828 (1)
    phip 41.5 1 14601045 (1)
    aflatoxin b1 39.4 2 8330352 (1)
    phenobarbital 32.6 1 16012075 (1)

    2 PharmGKB related drug/compound annotations for GSTA1 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    cyclophosphamideCA  



    Find genes that share compounds with GSTA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GSTA1 gene: 
    NM_145740.3  

    Unigene Cluster for GSTA1:

    Glutathione S-transferase alpha 1
    Hs.446309  [show with all ESTs]
    Unigene Representative Sequence: AL096729
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493331 ENST00000334575(uc003paz.3 uc021zan.1) ENST00000476213

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GSTA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GSTA1
    SwitchGear 3'UTR luciferase reporter plasmidGSTA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSTA1
    Predesigned siRNA for gene silencing in human, mouse, rat GSTA1
    Clone
    Products:
         
    OriGene clones in human, mouse for GSTA1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSTA1 (NM_145740)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSTA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GSTA1
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GSTA1
      QuantiTect SYBR Green Assays in human, mouse, rat GSTA1
      QuantiFast Probe-based Assays in human, mouse, rat GSTA1

    Additional mRNA sequence: 

    AK293371.1 AL096729.1 AY532928.1 BC053578.1 BC110891.1 CR407656.1 M14777.1 M15872.1 
    M21758.1 M25627.1 S49975.1 

    16 DOTS entries:

    DT.91702252  DT.452793  DT.100676913  DT.121406139  DT.100676915  DT.100676919  DT.91761490  DT.100676912 
    DT.100723252  DT.95143695  DT.100745080  DT.95175723  DT.121406142  DT.91761493  DT.100676916  DT.97805568 

    Selected AceView cDNA sequences (see all 152):

    BU949701 AA846513 AV702143 CB163833 AV653390 CR601508 AV652178 AI261839 
    H69204 AV703708 BI762502 AV707807 AV681855 BX506437 H91385 CB145964 
    BX283159 AA876288 R83309 AV707851 BV204430 H56244 AF020919 BV204472 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GSTA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCCAAGA
    GSTA1 Expression
    About this image


    GSTA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Gonad
             XY Germ Cells Testis Cord
    GSTA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSTA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446309

    UniProtKB/Swiss-Prot: GSTA1_HUMAN, P08263
    Tissue specificity: Liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSTA1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSTA1
    OriGene qSTAR qPCR primer pairs in human, mouse for GSTA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GSTA1
    QuantiTect SYBR Green Assays in human, mouse, rat GSTA1
    QuantiFast Probe-based Assays in human, mouse, rat GSTA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GSTA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    GSTA36
    --
    Gallus gallus glutathione S-transferase alpha 3 (G...
    65(a)
    65(a)
    many ↔ many
    many ↔ many
    3(87804937-87828658)
    3(87798977-87804665)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Glutathione S-transferase
    (see all 4)
    69(a)
    69(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(148460397-148466448)
    1(151781701-151787309)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW633886.12   -- 74.45(n)    AW633886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1739626
    gstal6
    (see all 3)
    glutathione S-transferase, alpha-like
    (see all 3)
    55(a)
    55(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    13(707116-712513) ENSDARG00000087431
    13(715869-724232) ENSDARG00000090228
    worm
    (Caenorhabditis elegans)
    Secernentea gst-416
    gst-106
    (see all 5)
    Protein GST-10 (gst-10) mRNA, complete cds
    (see all 5)
    29(a)
    27(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    V(7398465-7399302) WBGene00001789
    V(2561690-2564708) WBGene00001758
            Species with no ortholog for GSTA1

    ENSEMBL Gene Tree for GSTA1 (if available)
    TreeFam Gene Tree for GSTA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GSTA1 gene
    GSTA22  GSTA42  GSTA52  HPGDS2  GSTA32  
    6 SIMAP similar genes for GSTA1 using alignment to 1 protein entry:     GSTA1_HUMAN:
    GSTA2    GSTA3    GSTA5    GSTalpha locus    GSTA4    GSTP1

    Find genes that share paralogs with GSTA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GSTA1 (see all 532)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887293131,2
    --52655709(+) GCTGCA/CGGTAG 1 -- ds50010--------
    rs69042691,2
    C,F,A,H--52655827(+) GATTAA/GCACTA 1 -- ds500116Minor allele frequency- G:0.07NS NA WA CSA EA 1164
    rs1816238091,2
    --52655833(+) CACTAC/TGGGAC 1 -- ds50010--------
    rs1867573791,2
    --52655841(+) GACCAA/GTATGG 1 -- ds50010--------
    rs1920601761,2
    --52655918(+) TTTGCA/GTATAG 1 -- ds50010--------
    rs737406381,2
    C,F--52655933(+) TTGTAT/CTTCAC 1 -- ds50012Minor allele frequency- C:0.10WA 120
    rs1123636221,2
    C,F--52655945(+) TATACC/AATCTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs69087881,2
    C--52655955(+) GTATCT/GTGGCA 1 -- ds50019Minor allele frequency- G:0.00NA WA CSA EA 134
    rs69313291,2
    C,H--52656000(+) AGGCTC/TATGCC 1 -- ds500112Minor allele frequency- T:0.00NA WA CSA EA 373
    rs1441955441,2
    C--52656037(+) AGAGTA/GAGGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GSTA1 (52656178 - 52668708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GSTA1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666921CNV Deletion23128226
    esv2656678CNV Deletion23128226
    esv2732085CNV Deletion23290073
    esv2732086CNV Deletion23290073
    esv2436160CNV Deletion19546169
    esv4858CNV Duplication18987735
    nsv436888CNV Insertion17901297
    nsv470818CNV Loss18288195
    esv9378CNV Loss19470904
    nsv462945CNV Loss19166990

    Human Gene Mutation Database (HGMD): GSTA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSTA1
    DNA2.0 Custom Variant and Variant Library Synthesis for GSTA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 138359    OMIM disorders: --

    1 disease for GSTA1:    
    About MalaCards
    toxic encephalopathy

    14 diseases from the University of Copenhagen DISEASES database for GSTA1:
    Carcinoma     Hepatocellular carcinoma     Lung cancer     Schistosomiasis
    Colorectal cancer     Breast cancer     Liver disease     Urinary bladder cancer
    Prostate cancer     Asthma     Vascular disease     Adenoma
    Toxic encephalopathy     Leukemia

    Find genes that share disorders with GSTA1           About GenesLikeMe

    10 Novoseek inferred disease relationships for GSTA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 13 2 20056632 (1), 15746160 (1)
    bladder cancer 12.9 6 11061940 (5), 20204301 (1)
    breast cancer 8.32 14 16624829 (3), 18414193 (3), 12516103 (2), 19440493 (2)
    colorectal cancer 3.91 1 16886896 (1)
    cancer lung 0 3 15808404 (1), 17086718 (1)
    inflammation 0 3 18636040 (2), 17021248 (1)
    liver diseases 0 4 9049444 (2), 9727173 (2)
    adenocarcinoma 0 3 11550208 (3)
    tumors 0 4 11061940 (2), 11297599 (1), 18414193 (1)
    prostate cancer 0 3 20056632 (2), 15616829 (1)

    Genetic Association Database (GAD): GSTA1
    Human Genome Epidemiology (HuGE) Navigator: GSTA1 (83 documents)

    Export disorders for GSTA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GSTA1 gene, integrated from 10 sources (see all 247):
    (articles sorted by number of sources associating them with GSTA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation. (PubMed id 17425746)1, 4, 7, 9 Kim I....Kim B.K. (Clin Transplant 2007)
    2. Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. (PubMed id 20672371)1, 4, 7 Elhasid R....Efrati E. (amp 2010)
    3. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PubMed id 17333241)1, 4, 7 JAPnsson L.S....JAPnsson B.A. (Int Arch Occup Environ Health 2007)
    4. [Study on the genetic polymorphisms of human glutathione-S-transferase A1 in Hakka population in South China]. (PubMed id 17086718)1, 4, 9 Pan S.X....Ling W.H. (Wei Sheng Yan Jiu 2006)
    5. Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk. (PubMed id 16624829)1, 4, 9 Ahn J....Ambrosone C.B. (Carcinogenesis 2006)
    6. Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. (PubMed id 20377137)1, 4, 9 Nguyen T.V....Jansent J.B. (Oncol. Res. 2010)
    7. Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women. (PubMed id 18414193)1, 4, 9 Olsen A....nneland A. (Eur. J. Cancer Prev. 2008)
    8. Association between a glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment. (PubMed id 12516103)1, 4, 9 Sweeney C....Coles B.F. (Int. J. Cancer 2003)
    9. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. (PubMed id 11692074)1, 4, 9 Coles B.F....Kadlubar F.F. (Pharmacogenetics 2001)
    10. Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. (PubMed id 20331903)1, 4, 9 Chen Y.L....Tsai H.T. (BMC Med. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2938 HGNC: 4626 AceView: GSTA2andGSTA3andGSTA5 Ensembl:ENSG00000243955 euGenes: HUgn2938
    ECgene: GSTA1 Kegg: 2938 H-InvDB: GSTA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GSTA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSTA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GSTA1 gene:
    Search GeneIP for patents involving GSTA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Purified and/or Recombinant GSTA1 Protein
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GSTA1
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GSTA1   OriGene RNAi products in human, mouse, rat for GSTA1  
     OriGene qPCR primer pairs and template standards for GSTA1   OriGene Protein Over-expression Lysate for GSTA1  
     OriGene MassSpec for GSTA1   OriGene clones in human, mouse for GSTA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GSTA1   OriGene Purified Protein for GSTA1  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GSTA1   OriGene Custom Protein Services for GSTA1  

     
     
     Block miRNA regulation of human, mouse, rat GSTA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GSTA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSTA1 Predesigned siRNA for gene silencing in human, mouse, rat GSTA1
     QuantiFast Probe-based Assays in human, mouse, rat GSTA1 QuantiTect SYBR Green Assays in human, mouse, rat GSTA1
     PCR Arrays including human, mouse / rat GSTA1 Search Chromatin IP Primers for GSTA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GSTA1  GeneGlobe Interaction Network for GSTA1
     Regulatory tfbs in GSTA1 promoter
     GenScript Purified and Recombinant Proteins for GSTA1 GenScript cDNA clones with any tag delivered in your preferred vector for GSTA1
     GenScript Custom Assay Services for GSTA1 GenScript Custom overexpressing Cell Line Services for GSTA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GSTA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GSTA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GSTA1 antibodies
     GSTA1 proteins
     GSTA1 lysates
     Antibodies for GSTA1
     See all of Abcam's Antibodies, Kits and Proteins for GSTA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GSTA1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GSTA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSTA1
     SwitchGear 3'UTR luciferase reporter plasmids for GSTA1
     SwitchGear Promoter luciferase reporter plasmids for GSTA1
     ThermoFisher Antibody for GSTA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSTA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSTA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSTA1
     LSBio Antibodies in human, mouse, rat for GSTA1
     Browse compounds at ApexBio
     Search Addgene for plasmids for GSTA1
      Search eBioscience for proteins for GSTA1
      Search eBioscience for elisas for GSTA1
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for GSTA1 (68 products)
     antibodies-online kits for GSTA1 (33 products)
      Search antibodies-online for peptides for GSTA1
     antibodies-online proteins for GSTA1 (30 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GSTA1 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4